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Conserved domains on  [gi|398366361|ref|NP_010553|]
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iron-sulfur cluster assembly protein CIA1 [Saccharomyces cerevisiae S288C]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 6-325 1.68e-56

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 184.85  E-value: 1.68e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366361   6 LIKSLKLYKEKIWSFDFS--QGILATGSTDRKIKLVSVKYDDFtlidVLDETAHKKAIRSVAWRPHTSLLAAGSFDSTVS 83
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSpdGKLLATGSGDGTIKVWDLETGEL----LRTLKGHTGPVRDVAASADGTYLASGSSDKTIR 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366361  84 IWAKEESAdrtfemdLLAIIEGHENEVKGVAWSNDGYYLATCSRDKSVWIWETdesgEEYECISVLQEHSQDVKHVIWHP 163
Cdd:cd00200   77 LWDLETGE-------CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV----ETGKCLTTLRGHTDWVNSVAFSP 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366361 164 SEALLASSSYDDTVRIWKdyDDDWECVAVLNGHEGTVWSSDFDKTEgvFRLCSGSDDSTVRVWkymgddedDQQEWVCEA 243
Cdd:cd00200  146 DGTFVASSSQDGTIKLWD--LRTGKCVATLTGHTGEVNSVAFSPDG--EKLLSSSSDGTIKLW--------DLSTGKCLG 213

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366361 244 ILPdVHKRQVYNVAWGFNG-LIASVGADGVLAVYEEVDGEwkvfakralCHGVYE-----INVVKWleLNGKTILATGGD 317
Cdd:cd00200  214 TLR-GHENGVNSVAFSPDGyLLASGSEDGTIRVWDLRTGE---------CVQTLSghtnsVTSLAW--SPDGKRLASGSA 281


                 ....*...
gi 398366361 318 DGIVNFWS 325
Cdd:cd00200  282 DGTIRIWD 289
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 6-325 1.68e-56

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 184.85  E-value: 1.68e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366361   6 LIKSLKLYKEKIWSFDFS--QGILATGSTDRKIKLVSVKYDDFtlidVLDETAHKKAIRSVAWRPHTSLLAAGSFDSTVS 83
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSpdGKLLATGSGDGTIKVWDLETGEL----LRTLKGHTGPVRDVAASADGTYLASGSSDKTIR 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366361  84 IWAKEESAdrtfemdLLAIIEGHENEVKGVAWSNDGYYLATCSRDKSVWIWETdesgEEYECISVLQEHSQDVKHVIWHP 163
Cdd:cd00200   77 LWDLETGE-------CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV----ETGKCLTTLRGHTDWVNSVAFSP 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366361 164 SEALLASSSYDDTVRIWKdyDDDWECVAVLNGHEGTVWSSDFDKTEgvFRLCSGSDDSTVRVWkymgddedDQQEWVCEA 243
Cdd:cd00200  146 DGTFVASSSQDGTIKLWD--LRTGKCVATLTGHTGEVNSVAFSPDG--EKLLSSSSDGTIKLW--------DLSTGKCLG 213

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366361 244 ILPdVHKRQVYNVAWGFNG-LIASVGADGVLAVYEEVDGEwkvfakralCHGVYE-----INVVKWleLNGKTILATGGD 317
Cdd:cd00200  214 TLR-GHENGVNSVAFSPDGyLLASGSEDGTIRVWDLRTGE---------CVQTLSghtnsVTSLAW--SPDGKRLASGSA 281


                 ....*...
gi 398366361 318 DGIVNFWS 325
Cdd:cd00200  282 DGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
6-276 1.38e-43

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 154.30  E-value: 1.38e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366361   6 LIKSLKLYKEKIWSFDFSQG--ILATGSTDRKIKLVSVkyDDFTLIDVLdeTAHKKAIRSVAWRPHTSLLAAGSFDSTVS 83
Cdd:COG2319  154 LLRTLTGHSGAVTSVAFSPDgkLLASGSDDGTVRLWDL--ATGKLLRTL--TGHTGAVRSVAFSPDGKLLASGSADGTVR 229

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366361  84 IWakeeSADRTfemDLLAIIEGHENEVKGVAWSNDGYYLATCSRDKSVWIWETDESgeeyECISVLQEHSQDVKHVIWHP 163
Cdd:COG2319  230 LW----DLATG---KLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATG----ELLRTLTGHSGGVNSVAFSP 298

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366361 164 SEALLASSSYDDTVRIWkdyD-DDWECVAVLNGHEGTVWSSDFDKTEGvfRLCSGSDDSTVRVWkymgddedDQQEWVCE 242
Cdd:COG2319  299 DGKLLASGSDDGTVRLW---DlATGKLLRTLTGHTGAVRSVAFSPDGK--TLASGSDDGTVRLW--------DLATGELL 365

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 398366361 243 AILPDvHKRQVYNVAWGFNG-LIASVGADGVLAVY 276
Cdd:COG2319  366 RTLTG-HTGAVTSVAFSPDGrTLASGSADGTVRLW 399
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 99-135 6.63e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.08  E-value: 6.63e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 398366361    99 LLAIIEGHENEVKGVAWSNDGYYLATCSRDKSVWIWE 135
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
99-135 1.54e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.26  E-value: 1.54e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 398366361   99 LLAIIEGHENEVKGVAWSNDGYYLATCSRDKSVWIWE 135
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 108-226 3.11e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 48.93  E-value: 3.11e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366361 108 NEVKGVAWSNDGYYLATCSRDKSVWIwetdesgeeYECISVLQEhSQDVKH-------------VIWHPS-EALLASSSY 173
Cdd:PLN00181 484 NLVCAIGFDRDGEFFATAGVNKKIKI---------FECESIIKD-GRDIHYpvvelasrsklsgICWNSYiKSQVASSNF 553

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 398366361 174 DDTVRIWKDYDDdwECVAVLNGHEGTVWSSDFDKTEGVFrLCSGSDDSTVRVW 226
Cdd:PLN00181 554 EGVVQVWDVARS--QLVTEMKEHEKRVWSIDYSSADPTL-LASGSDDGSVKLW 603
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 6-325 1.68e-56

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 184.85  E-value: 1.68e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366361   6 LIKSLKLYKEKIWSFDFS--QGILATGSTDRKIKLVSVKYDDFtlidVLDETAHKKAIRSVAWRPHTSLLAAGSFDSTVS 83
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSpdGKLLATGSGDGTIKVWDLETGEL----LRTLKGHTGPVRDVAASADGTYLASGSSDKTIR 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366361  84 IWAKEESAdrtfemdLLAIIEGHENEVKGVAWSNDGYYLATCSRDKSVWIWETdesgEEYECISVLQEHSQDVKHVIWHP 163
Cdd:cd00200   77 LWDLETGE-------CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV----ETGKCLTTLRGHTDWVNSVAFSP 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366361 164 SEALLASSSYDDTVRIWKdyDDDWECVAVLNGHEGTVWSSDFDKTEgvFRLCSGSDDSTVRVWkymgddedDQQEWVCEA 243
Cdd:cd00200  146 DGTFVASSSQDGTIKLWD--LRTGKCVATLTGHTGEVNSVAFSPDG--EKLLSSSSDGTIKLW--------DLSTGKCLG 213

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366361 244 ILPdVHKRQVYNVAWGFNG-LIASVGADGVLAVYEEVDGEwkvfakralCHGVYE-----INVVKWleLNGKTILATGGD 317
Cdd:cd00200  214 TLR-GHENGVNSVAFSPDGyLLASGSEDGTIRVWDLRTGE---------CVQTLSghtnsVTSLAW--SPDGKRLASGSA 281


                 ....*...
gi 398366361 318 DGIVNFWS 325
Cdd:cd00200  282 DGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
6-276 1.38e-43

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 154.30  E-value: 1.38e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366361   6 LIKSLKLYKEKIWSFDFSQG--ILATGSTDRKIKLVSVkyDDFTLIDVLdeTAHKKAIRSVAWRPHTSLLAAGSFDSTVS 83
Cdd:COG2319  154 LLRTLTGHSGAVTSVAFSPDgkLLASGSDDGTVRLWDL--ATGKLLRTL--TGHTGAVRSVAFSPDGKLLASGSADGTVR 229

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366361  84 IWakeeSADRTfemDLLAIIEGHENEVKGVAWSNDGYYLATCSRDKSVWIWETDESgeeyECISVLQEHSQDVKHVIWHP 163
Cdd:COG2319  230 LW----DLATG---KLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATG----ELLRTLTGHSGGVNSVAFSP 298

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366361 164 SEALLASSSYDDTVRIWkdyD-DDWECVAVLNGHEGTVWSSDFDKTEGvfRLCSGSDDSTVRVWkymgddedDQQEWVCE 242
Cdd:COG2319  299 DGKLLASGSDDGTVRLW---DlATGKLLRTLTGHTGAVRSVAFSPDGK--TLASGSDDGTVRLW--------DLATGELL 365

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 398366361 243 AILPDvHKRQVYNVAWGFNG-LIASVGADGVLAVY 276
Cdd:COG2319  366 RTLTG-HTGAVTSVAFSPDGrTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
6-327 8.42e-43

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 152.37  E-value: 8.42e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366361   6 LIKSLKLYKEKIWSFDFS--QGILATGSTDRKIKLVSVkyDDFTLIDVLdeTAHKKAIRSVAWRPHTSLLAAGSFDSTVS 83
Cdd:COG2319  112 LLRTLTGHTGAVRSVAFSpdGKTLASGSADGTVRLWDL--ATGKLLRTL--TGHSGAVTSVAFSPDGKLLASGSDDGTVR 187

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366361  84 IWakeesadRTFEMDLLAIIEGHENEVKGVAWSNDGYYLATCSRDKSVWIWETDESgeeyECISVLQEHSQDVKHVIWHP 163
Cdd:COG2319  188 LW-------DLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATG----KLLRTLTGHSGSVRSVAFSP 256

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366361 164 SEALLASSSYDDTVRIWkdyD-DDWECVAVLNGHEGTVWSSDFDKTEGvfRLCSGSDDSTVRVWkymgddedDQQEWVCE 242
Cdd:COG2319  257 DGRLLASGSADGTVRLW---DlATGELLRTLTGHSGGVNSVAFSPDGK--LLASGSDDGTVRLW--------DLATGKLL 323

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366361 243 AILPDvHKRQVYNVAWGFNG-LIASVGADGVLAVYEeVDGEWKVFAKRAlcHGvYEINVVKWLElNGKTiLATGGDDGIV 321
Cdd:COG2319  324 RTLTG-HTGAVRSVAFSPDGkTLASGSDDGTVRLWD-LATGELLRTLTG--HT-GAVTSVAFSP-DGRT-LASGSADGTV 396


                 ....*.
gi 398366361 322 NFWSLE 327
Cdd:COG2319  397 RLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
18-327 3.07e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 137.35  E-value: 3.07e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366361  18 WSFDFSQGILATGSTDRKIKLVsvkyDDFTLIDVLDETAHKKAIRSVAWRPHTSLLAAGSFDSTVSIWAKEESAdrtfem 97
Cdd:COG2319   42 LAASPDGARLAAGAGDLTLLLL----DAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGL------ 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366361  98 dLLAIIEGHENEVKGVAWSNDGYYLATCSRDKSVWIWETDESgeeyECISVLQEHSQDVKHVIWHPSEALLASSSYDDTV 177
Cdd:COG2319  112 -LLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATG----KLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTV 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366361 178 RIWKdyDDDWECVAVLNGHEGTVWSSDF--DKTegvfRLCSGSDDSTVRVWkymgddedDQQEWVCEAILPDvHKRQVYN 255
Cdd:COG2319  187 RLWD--LATGKLLRTLTGHTGAVRSVAFspDGK----LLASGSADGTVRLW--------DLATGKLLRTLTG-HSGSVRS 251

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 398366361 256 VAWGFNG-LIASVGADGVLAVYEEVDGEWkvfaKRALCHGVYEINVVKWLElNGKTiLATGGDDGIVNFWSLE 327
Cdd:COG2319  252 VAFSPDGrLLASGSADGTVRLWDLATGEL----LRTLTGHSGGVNSVAFSP-DGKL-LASGSDDGTVRLWDLA 318
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 99-135 6.63e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.08  E-value: 6.63e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 398366361    99 LLAIIEGHENEVKGVAWSNDGYYLATCSRDKSVWIWE 135
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 144-181 1.14e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 1.14e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 398366361   144 ECISVLQEHSQDVKHVIWHPSEALLASSSYDDTVRIWK 181
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
99-135 1.54e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.26  E-value: 1.54e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 398366361   99 LLAIIEGHENEVKGVAWSNDGYYLATCSRDKSVWIWE 135
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 108-226 3.11e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 48.93  E-value: 3.11e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366361 108 NEVKGVAWSNDGYYLATCSRDKSVWIwetdesgeeYECISVLQEhSQDVKH-------------VIWHPS-EALLASSSY 173
Cdd:PLN00181 484 NLVCAIGFDRDGEFFATAGVNKKIKI---------FECESIIKD-GRDIHYpvvelasrsklsgICWNSYiKSQVASSNF 553

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 398366361 174 DDTVRIWKDYDDdwECVAVLNGHEGTVWSSDFDKTEGVFrLCSGSDDSTVRVW 226
Cdd:PLN00181 554 EGVVQVWDVARS--QLVTEMKEHEKRVWSIDYSSADPTL-LASGSDDGSVKLW 603
WD40 pfam00400
WD domain, G-beta repeat;
144-180 4.00e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.10  E-value: 4.00e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 398366361  144 ECISVLQEHSQDVKHVIWHPSEALLASSSYDDTVRIW 180
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
PTZ00420 PTZ00420
coronin; Provisional
 22-99 1.68e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 46.48  E-value: 1.68e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366361  22 FSQgILATGSTDRKIKLVSVKYDDFTLIDVLDE----TAHKKAIRSVAWRP-HTSLLAAGSFDSTVSIWaKEESADRTFE 96
Cdd:PTZ00420  86 FSE-ILASGSEDLTIRVWEIPHNDESVKEIKDPqcilKGHKKKISIIDWNPmNYYIMCSSGFDSFVNIW-DIENEKRAFQ 163


                 ...
gi 398366361  97 MDL 99
Cdd:PTZ00420 164 INM 166
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 186-227 3.25e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 3.25e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 398366361   186 DWECVAVLNGHEGTVWSSDFDKTEGvfRLCSGSDDSTVRVWK 227
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGK--YLASGSDDGTIKLWD 40
PTZ00420 PTZ00420
coronin; Provisional
 51-146 4.80e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 44.94  E-value: 4.80e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366361  51 VLDETAHKKAIRSVAWRP-HTSLLAAGSFDSTVSIWAKEESADRTFEM-DLLAIIEGHENEVKGVAWSNDGYY-LATCSR 127
Cdd:PTZ00420  67 VIKLKGHTSSILDLQFNPcFSEILASGSEDLTIRVWEIPHNDESVKEIkDPQCILKGHKKKISIIDWNPMNYYiMCSSGF 146

                         90
                 ....*....|....*....
gi 398366361 128 DKSVWIWETDESGEEYECI 146
Cdd:PTZ00420 147 DSFVNIWDIENEKRAFQIN 165
PTZ00420 PTZ00420
coronin; Provisional
 122-180 8.59e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 44.17  E-value: 8.59e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 398366361 122 LATCSRDKSVWIWE---TDESGEEY---ECIsvLQEHSQDVKHVIWHP-SEALLASSSYDDTVRIW 180
Cdd:PTZ00420  90 LASGSEDLTIRVWEiphNDESVKEIkdpQCI--LKGHKKKISIIDWNPmNYYIMCSSGFDSFVNIW 153
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 55-85 1.35e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 1.35e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 398366361    55 TAHKKAIRSVAWRPHTSLLAAGSFDSTVSIW 85
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
55-85 1.64e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 1.64e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 398366361   55 TAHKKAIRSVAWRPHTSLLAAGSFDSTVSIW 85
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
187-226 1.90e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 1.90e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 398366361  187 WECVAVLNGHEGTVWSSDFDKTEGVfrLCSGSDDSTVRVW 226
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKL--LASGSDDGTVKVW 38
PTZ00421 PTZ00421
coronin; Provisional
 102-225 1.95e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 39.88  E-value: 1.95e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366361 102 IIEGHENEVKGVAWSN-DGYYLATCSRDKSVWIWETDESGEEYEC---ISVLQEHSQDVKHVIWHPSEAL-LASSSYDDT 176
Cdd:PTZ00421  70 ILLGQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGIPEEGLTQNIsdpIVHLQGHTKKVGIVSFHPSAMNvLASAGADMV 149

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 398366361 177 VRIWKdydddwecvaVLNGHEGTVWSSDFDKTEGV------FRLCSGSDDSTVRV 225
Cdd:PTZ00421 150 VNVWD----------VERGKAVEVIKCHSDQITSLewnldgSLLCTTSKDKKLNI 194
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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