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Conserved domains on  [gi|6320490|ref|NP_010570|]
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bifunctional diacylglycerol diphosphate phosphatase/phosphatidate phosphatase [Saccharomyces cerevisiae S288C]

Protein Classification

phosphatase PAP2 family protein( domain architecture ID 10130247)

type 2 phosphatidic acid phosphatase (PAP2) family protein similar to mammalian phospholipid phosphatases that catalyzes the conversion of phosphatidic acid to diacylglycerol

EC:  3.1.3.-
Gene Ontology:  GO:0006644|GO:0008195|GO:0046839
PubMed:  12447906

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PAP2_containing_1_like cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. ...
 50-245 2.18e-83

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity, they may have a more generic housekeeping role in lipid metabolism.


:

Pssm-ID: 239484 [Multi-domain]  Cd Length: 193  Bit Score: 248.67  E-value: 2.18e-83
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320490   50 LTISHPYATTERVNNNMLFVYSFVVPSLTILIIGSILADRRHLifiLYTSLLGLSLAWFSTSFFTNFIKNWIGRLRPDFL 129
Cdd:cd03390   1 PSISYPFAESETVPTWLLVIISVGIPLLVIILISLFFRRSLWD---LHTSLLGLLLSVSLNGVITNVLKNYAGRPRPDFL 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320490  130 DRCQPVEGLPLDTLFTAkDVCTTKNHERLLDGFRTTPSGHSSESFAGLGYLYFWLCGQLLTESPLMPLWRKMVAFLPLLG 209
Cdd:cd03390  78 ARCFPDGGTPSDTLVGI-DICCTGDPGVLKEGRKSFPSGHSSFAFAGLGFLSLYLAGKLHIFDPRGSSWRLLLALLPLLL 156

                       170       180       190
                ....*....|....*....|....*....|....*.
gi 6320490  210 AALIALSRTQDYRHHFVDVILGSMLGYIMAHFFYRR 245
Cdd:cd03390 157 AILVAVSRTRDYRHHFSDVIAGSLIGLIIAYLSYRQ 192
 
Name Accession Description Interval E-value
PAP2_containing_1_like cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. ...
 50-245 2.18e-83

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity, they may have a more generic housekeeping role in lipid metabolism.


Pssm-ID: 239484 [Multi-domain]  Cd Length: 193  Bit Score: 248.67  E-value: 2.18e-83
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320490   50 LTISHPYATTERVNNNMLFVYSFVVPSLTILIIGSILADRRHLifiLYTSLLGLSLAWFSTSFFTNFIKNWIGRLRPDFL 129
Cdd:cd03390   1 PSISYPFAESETVPTWLLVIISVGIPLLVIILISLFFRRSLWD---LHTSLLGLLLSVSLNGVITNVLKNYAGRPRPDFL 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320490  130 DRCQPVEGLPLDTLFTAkDVCTTKNHERLLDGFRTTPSGHSSESFAGLGYLYFWLCGQLLTESPLMPLWRKMVAFLPLLG 209
Cdd:cd03390  78 ARCFPDGGTPSDTLVGI-DICCTGDPGVLKEGRKSFPSGHSSFAFAGLGFLSLYLAGKLHIFDPRGSSWRLLLALLPLLL 156

                       170       180       190
                ....*....|....*....|....*....|....*.
gi 6320490  210 AALIALSRTQDYRHHFVDVILGSMLGYIMAHFFYRR 245
Cdd:cd03390 157 AILVAVSRTRDYRHHFSDVIAGSLIGLIIAYLSYRQ 192
PLN02250 PLN02250
lipid phosphate phosphatase
 15-258 5.96e-31

lipid phosphate phosphatase


Pssm-ID: 215139  Cd Length: 314  Bit Score: 117.72  E-value: 5.96e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320490    15 AKWRLEDVFLLIIMILLNYPVYYQQPFERQFYINDLT-ISHPYATtervnNNMLF----VYSFVVPSLTILIIGSIladr 89
Cdd:PLN02250  19 ARTHMHDWLILLLLVVIEVVLNVIEPFHRFVGKDMLTdLSYPLQD-----NTIPFwavpLIAILLPFAVILVYYFI---- 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320490    90 RHLIFILYTSLLGLSLAWFSTSFFTNFIKNWIGRLRPDFLDRCQPVEGLPLDTLftAKDVCTTKNHERLLDGFRTTPSGH 169
Cdd:PLN02250  90 RRDVYDLHHAILGLLFSVLITGVITDAIKDAVGRPRPDFFWRCFPDGKGVFHPV--TTDVLCTGAKSVIKEGHKSFPSGH 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320490   170 SSESFAGLGYLYFWLCGQLLTESPLMPLWRKMVAFLPLLGAALIALSRTQDYRHHFVDVILGSMLGYIMAHFFYRRIFPP 249
Cdd:PLN02250 168 TSWSFAGLGFLSLYLSGKIRVFDRRGHVAKLCIVFLPLLVAALVGVSRVDDYWHHWQDVFAGALIGLTVASFCYLQFFPP 247


                 ....*....
gi 6320490   250 IDDPLPFKP 258
Cdd:PLN02250 248 PYDIDGWGP 256
acidPPc smart00014
Acid phosphatase homologues;
109-243 3.80e-24

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 93.95  E-value: 3.80e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320490     109 STSFFTNFIKNWIGRLRPDFLDrcqpveglpldtlftAKDVCTTKNHERLLDGFRTTPSGHSSESFAGLGYLYFWLCGQL 188
Cdd:smart00014   6 VSQLFNGVIKNYFGRPRPFFLS---------------IGDACCTPNFLLTLEAGYSFPSGHTAFAFAFALFLLLYLPARA 70

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 6320490     189 LtesplmplwRKMVAFLPLLGAALIALSRTQDYRHHFVDVILGSMLGYIMAHFFY 243
Cdd:smart00014  71 G---------RKLLIFLLLLLALVVGFSRVYLGAHWPSDVLAGSLLGILIAAVLF 116
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 101-247 1.97e-18

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 79.39  E-value: 1.97e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320490    101 LGLSLAwfSTSFFTNFIKNWIGRLRPDFLDRCQPveglpldtlftakdvcTTKNHERLLDGFRTTPSGHSSESFAGLGYL 180
Cdd:pfam01569   2 LLLALA--LAGLLSSVLKDYFGRPRPFFLLLEGG----------------LVPAPSTLPGLGYSFPSGHSATAFALALLL 63

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6320490    181 YFWLCgqlltesPLMPLWRKMVAFLPLLGAALIALSRTQDYRHHFVDVILGSMLGYIMAHFFYRRIF 247
Cdd:pfam01569  64 ALLLR-------RLRKIVRVLLALLLLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLVYRLVP 123
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 26-244 1.04e-09

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 56.97  E-value: 1.04e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320490   26 IIMILLNYPVYYQQPFERQFYINDLTISHPYATTERVNNNMLFVYSFVVPSLTILIIGSILADRRHLIFILYTSLLGLSL 105
Cdd:COG0671   1 LLLALLLALLLLLLLLADLLALALLALLLLLALLLLLLLLLALLLILLLLLLLLLLLLLLLLLLLRLLALLLLLLLLAAL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320490  106 AWFSTSFFTNFIKNWIGRLRPDFLDRCQPVEGLPLDTLFtakdvcttknherlldgfrttPSGHSSESFAGLGYLYFWLc 185
Cdd:COG0671  81 LLLLLLLLLLLLKYLFGRPRPFVVPDLELLLGTAGGYSF---------------------PSGHAAAAFALALVLALLL- 138

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 6320490  186 gqlltesplmplWRKMVAFLPLLGAALIALSRTQDYRHHFVDVILGSMLGYIMAHFFYR 244
Cdd:COG0671 139 ------------PRRWLAALLLALALLVGLSRVYLGVHYPSDVLAGALLGLAIALLLLA 185
 
Name Accession Description Interval E-value
PAP2_containing_1_like cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. ...
 50-245 2.18e-83

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity, they may have a more generic housekeeping role in lipid metabolism.


Pssm-ID: 239484 [Multi-domain]  Cd Length: 193  Bit Score: 248.67  E-value: 2.18e-83
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320490   50 LTISHPYATTERVNNNMLFVYSFVVPSLTILIIGSILADRRHLifiLYTSLLGLSLAWFSTSFFTNFIKNWIGRLRPDFL 129
Cdd:cd03390   1 PSISYPFAESETVPTWLLVIISVGIPLLVIILISLFFRRSLWD---LHTSLLGLLLSVSLNGVITNVLKNYAGRPRPDFL 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320490  130 DRCQPVEGLPLDTLFTAkDVCTTKNHERLLDGFRTTPSGHSSESFAGLGYLYFWLCGQLLTESPLMPLWRKMVAFLPLLG 209
Cdd:cd03390  78 ARCFPDGGTPSDTLVGI-DICCTGDPGVLKEGRKSFPSGHSSFAFAGLGFLSLYLAGKLHIFDPRGSSWRLLLALLPLLL 156

                       170       180       190
                ....*....|....*....|....*....|....*.
gi 6320490  210 AALIALSRTQDYRHHFVDVILGSMLGYIMAHFFYRR 245
Cdd:cd03390 157 AILVAVSRTRDYRHHFSDVIAGSLIGLIIAYLSYRQ 192
PLN02250 PLN02250
lipid phosphate phosphatase
 15-258 5.96e-31

lipid phosphate phosphatase


Pssm-ID: 215139  Cd Length: 314  Bit Score: 117.72  E-value: 5.96e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320490    15 AKWRLEDVFLLIIMILLNYPVYYQQPFERQFYINDLT-ISHPYATtervnNNMLF----VYSFVVPSLTILIIGSIladr 89
Cdd:PLN02250  19 ARTHMHDWLILLLLVVIEVVLNVIEPFHRFVGKDMLTdLSYPLQD-----NTIPFwavpLIAILLPFAVILVYYFI---- 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320490    90 RHLIFILYTSLLGLSLAWFSTSFFTNFIKNWIGRLRPDFLDRCQPVEGLPLDTLftAKDVCTTKNHERLLDGFRTTPSGH 169
Cdd:PLN02250  90 RRDVYDLHHAILGLLFSVLITGVITDAIKDAVGRPRPDFFWRCFPDGKGVFHPV--TTDVLCTGAKSVIKEGHKSFPSGH 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320490   170 SSESFAGLGYLYFWLCGQLLTESPLMPLWRKMVAFLPLLGAALIALSRTQDYRHHFVDVILGSMLGYIMAHFFYRRIFPP 249
Cdd:PLN02250 168 TSWSFAGLGFLSLYLSGKIRVFDRRGHVAKLCIVFLPLLVAALVGVSRVDDYWHHWQDVFAGALIGLTVASFCYLQFFPP 247


                 ....*....
gi 6320490   250 IDDPLPFKP 258
Cdd:PLN02250 248 PYDIDGWGP 256
PLN02731 PLN02731
Putative lipid phosphate phosphatase
 15-249 2.93e-28

Putative lipid phosphate phosphatase


Pssm-ID: 178332  Cd Length: 333  Bit Score: 110.89  E-value: 2.93e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320490    15 AKWRLEDVFLLIIMILLNYPVYYQQPFERqFYINDLTISHPYAtterVNNNMLFVYSFVVPSLTI-LIIGSILADRRHLI 93
Cdd:PLN02731  38 ARTHMHDWIILVLLVILECVLLIIHPFYR-FVGKDMMTDLSYP----LKSNTVPIWSVPVYAMLLpLVIFIFIYFRRRDV 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320490    94 FILYTSLLGLSLAWFSTSFFTNFIKNWIGRLRPDFLDRCQPVEGLPLDTLftaKDVCTTKNHERLLDGFRTTPSGHSSES 173
Cdd:PLN02731 113 YDLHHAVLGLLYSVLVTAVLTDAIKNAVGRPRPDFFWRCFPDGKALYDSL---GDVICHGDKSVIREGHKSFPSGHTSWS 189

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6320490   174 FAGLGYLYFWLCGQLLTESPLMPLWRKMVAFLPLLGAALIALSRTQDYRHHFVDVILGSMLGYIMAHFFYRRIFPP 249
Cdd:PLN02731 190 FSGLGFLSLYLSGKIQAFDGKGHVAKLCIVILPLLFAALVGISRVDDYWHHWQDVFAGGLLGLAISTICYLQFFPP 265
PAP2_wunen cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid ...
 98-242 3.60e-25

PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors.


Pssm-ID: 239479  Cd Length: 150  Bit Score: 97.70  E-value: 3.60e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320490   98 TSLLGLslawFSTSFFTNFIKNWIGRLRPDFLDRCQP---VEGLPLDTLFTAKDVCTTKNHERLLDGFRTTPSGHSSESF 174
Cdd:cd03384   8 VFLFGL----FATQLLTDLGKYVTGRLRPHFLDVCKPnytDLTCSLDHQYIADCTCCTGDPDLIREARLSFPSGHASLSM 83

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6320490  175 AGLGYLYFWLcgQLLTESPLMPLWRKMVAFLPLLGAALIALSRTQDYRHHFVDVILGSMLGYIMAHFF 242
Cdd:cd03384  84 YAAVFLALYL--QARLKLRGSRLLRPLLQFLLLALALYVGLSRISDYKHHWSDVLAGALLGSVIALFL 149
acidPPc smart00014
Acid phosphatase homologues;
109-243 3.80e-24

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 93.95  E-value: 3.80e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320490     109 STSFFTNFIKNWIGRLRPDFLDrcqpveglpldtlftAKDVCTTKNHERLLDGFRTTPSGHSSESFAGLGYLYFWLCGQL 188
Cdd:smart00014   6 VSQLFNGVIKNYFGRPRPFFLS---------------IGDACCTPNFLLTLEAGYSFPSGHTAFAFAFALFLLLYLPARA 70

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 6320490     189 LtesplmplwRKMVAFLPLLGAALIALSRTQDYRHHFVDVILGSMLGYIMAHFFY 243
Cdd:smart00014  71 G---------RKLLIFLLLLLALVVGFSRVYLGAHWPSDVLAGSLLGILIAAVLF 116
PLN02715 PLN02715
lipid phosphate phosphatase
 21-248 6.39e-24

lipid phosphate phosphatase


Pssm-ID: 178317 [Multi-domain]  Cd Length: 327  Bit Score: 98.97  E-value: 6.39e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320490    21 DVFLLIIMILLNYPVYYQQPFERQFYINDLT-ISHPYattervNNNMLFVYSFVVPSLTILIIGSI-LADRRHLIFILYT 98
Cdd:PLN02715  50 DWIILVILIAIEIGLNLISPFYRYVGKDMMTdLKYPF------KDNTVPIWSVPVYAVLLPIILFVcFYLKRRCVYDLHH 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320490    99 SLLGLSLAWFSTSFFTNFIKNWIGRLRPDFLDRCQPVEGLPLDTLftAKDVCTTKNHErLLDGFRTTPSGHSSESFAGLG 178
Cdd:PLN02715 124 SILGLLFAVLITGVITDSIKVATGRPRPNFYWRCFPDGKELYDAL--GGVICHGKAAE-VKEGHKSFPSGHTSWSFAGLT 200

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320490   179 YLYFWLCGQLLTESPLMPLWRKMVAFLPLLGAALIALSRTQDYRHHFVDVILGSMLGYIMAHFFYRRIFP 248
Cdd:PLN02715 201 FLSLYLSGKIKAFNGEGHVAKLCLVIFPLLAACLVGISRVDDYWHHWQDVFAGALIGILVAAFCYRQFYP 270
PAP2_like cd01610
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, ...
 96-243 1.97e-21

PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid phosphatase, vanadium chloroperoxidases, vanadium bromoperoxidases, and several other mostly uncharacterized subfamilies. Several members of this superfamily have been predicted to be transmembrane proteins.


Pssm-ID: 238813 [Multi-domain]  Cd Length: 122  Bit Score: 87.13  E-value: 1.97e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320490   96 LYTSLLGLSLAWFSTSFFTNFIKNWIGRLRPDFLDRCQPVEGLPLDTlftakdvcttknherllDGFRTTPSGHSSESFA 175
Cdd:cd01610   1 RRLLALLLLLALLAGLLLTGVLKYLFGRPRPYFLLRCGPDGDPLLLT-----------------EGGYSFPSGHAAFAFA 63

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6320490  176 GLGYLYFWLCGQLltesplmplWRKMVAFLPLLGAALIALSRTQDYRHHFVDVILGSMLGYIMAHFFY 243
Cdd:cd01610  64 LALFLALLLPRRL---------LRLLLGLLLLLLALLVGLSRVYLGVHYPSDVLAGALLGILVALLVL 122
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 101-247 1.97e-18

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 79.39  E-value: 1.97e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320490    101 LGLSLAwfSTSFFTNFIKNWIGRLRPDFLDRCQPveglpldtlftakdvcTTKNHERLLDGFRTTPSGHSSESFAGLGYL 180
Cdd:pfam01569   2 LLLALA--LAGLLSSVLKDYFGRPRPFFLLLEGG----------------LVPAPSTLPGLGYSFPSGHSATAFALALLL 63

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6320490    181 YFWLCgqlltesPLMPLWRKMVAFLPLLGAALIALSRTQDYRHHFVDVILGSMLGYIMAHFFYRRIF 247
Cdd:pfam01569  64 ALLLR-------RLRKIVRVLLALLLLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLVYRLVP 123
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 26-244 1.04e-09

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 56.97  E-value: 1.04e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320490   26 IIMILLNYPVYYQQPFERQFYINDLTISHPYATTERVNNNMLFVYSFVVPSLTILIIGSILADRRHLIFILYTSLLGLSL 105
Cdd:COG0671   1 LLLALLLALLLLLLLLADLLALALLALLLLLALLLLLLLLLALLLILLLLLLLLLLLLLLLLLLLRLLALLLLLLLLAAL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320490  106 AWFSTSFFTNFIKNWIGRLRPDFLDRCQPVEGLPLDTLFtakdvcttknherlldgfrttPSGHSSESFAGLGYLYFWLc 185
Cdd:COG0671  81 LLLLLLLLLLLLKYLFGRPRPFVVPDLELLLGTAGGYSF---------------------PSGHAAAAFALALVLALLL- 138

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 6320490  186 gqlltesplmplWRKMVAFLPLLGAALIALSRTQDYRHHFVDVILGSMLGYIMAHFFYR 244
Cdd:COG0671 139 ------------PRRWLAALLLALALLVGLSRVYLGVHYPSDVLAGALLGLAIALLLLA 185
PAP2_lipid_A_1_phosphatase cd03389
PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from ...
 72-246 1.25e-09

PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major constituents of the outer membrane in many gram-negative bacteria.


Pssm-ID: 239483  Cd Length: 186  Bit Score: 56.56  E-value: 1.25e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320490   72 FVVPSLtILIIGSILADRRHLIFILYTSLLGLSLAW---FST----SFFTNFIKNWIGRLRPD-FLDrcqpvEGLPLDTL 143
Cdd:cd03389  37 YLIPSL-LLFLLFRFGDLRGLSAPSRARFPKAAWAGlflFATvalsGILVNLLKFIIGRARPKlLFD-----DGLYGFDP 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320490  144 FTAKDvcttknherlldGFRTTPSGHSSESFAGLGYLYFwlcgqlltespLMPLWRkmvaFLPLLGAALIALSRTQDYRH 223
Cdd:cd03389 111 FHADY------------AFTSFPSGHSATAGAAAAALAL-----------LFPRYR----WAFILLALLIAFSRVIVGAH 163

                       170       180
                ....*....|....*....|...
gi 6320490  224 HFVDVILGSMLGYIMAHFFYRRI 246
Cdd:cd03389 164 YPSDVIAGSLLGAVTALALYQRF 186
PAP2_like_5 cd03394
PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 160-243 4.42e-09

PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239488 [Multi-domain]  Cd Length: 106  Bit Score: 53.10  E-value: 4.42e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320490  160 DGFRTTPSGHSSESFAGLGYL---YFWlcgqlltesPLMPLWrkmvAFLpllGAALIALSRTQDYRHHFVDVILGSMLGY 236
Cdd:cd03394  36 NGYRSFPSGHTASAFAAATFLqyrYGW---------RWYGIP----AYA---LASLVGASRVVANRHWLSDVLAGAAIGI 99


                ....*..
gi 6320490  237 IMAHFFY 243
Cdd:cd03394 100 LVGYLVT 106
PAP2_like_4 cd03395
PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 66-244 2.71e-04

PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239489  Cd Length: 177  Bit Score: 40.71  E-value: 2.71e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320490   66 MLFVYSFV--VPSLTILIIGSILADRRHLIFILytsLLGLSLAWFSTSFFTNFIKNWIGRLRPdfldrCQPVEGLPLDTL 143
Cdd:cd03395  26 MPFLTGKKlsVPIFLLLALFILFRKGPIGLLIL---LLVLLAVGFADQLASGFLKPLVARLRP-----CNALDGVRLVVL 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320490  144 FTakdvcTTKNHerlldGFrttPSGHSSESFAGLgyLYFWLCGQLLTESPLMPLWrkmvaflpllgAALIALSRTQDYRH 223
Cdd:cd03395  98 GD-----QGGSY-----SF---ASSHAANSFALA--LFIWLFFRRGLFSPVLLLW-----------ALLVGYSRVYVGVH 151

                       170       180
                ....*....|....*....|.
gi 6320490  224 HFVDVILGSMLGYIMAHFFYR 244
Cdd:cd03395 152 YPGDVIAGALIGIISGLLFYL 172
PAP2_containing_2_like cd03391
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. ...
 166-241 5.69e-04

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to eukaryota, lacks functional characterization and may act as a membrane-associated phosphatidic acid phosphatase.


Pssm-ID: 239485 [Multi-domain]  Cd Length: 159  Bit Score: 39.61  E-value: 5.69e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6320490  166 PSGHSSESFAGLGYLYFWLcgqLLTESPLMPLWrkmvaflplLGAALIALSRTQDYRHHFVDVILGSMLGYIMAHF 241
Cdd:cd03391  94 PSGHASRAAFVARFLLNHL---VLAVPLRVLLV---------LWATVVGISRVLLGRHHVLDVLAGAFLGYLEALL 157
PAP2_like_2 cd03392
PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 72-237 5.91e-04

PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239486  Cd Length: 182  Bit Score: 39.90  E-value: 5.91e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320490   72 FVVPSLTILIIGSILADRRHLIFILYTSLLGLSLawfstsfFTNFIKNWIGRLRPDFLdrcqpveglpldtlftakdvct 151
Cdd:cd03392  43 VLLIIVLLLALLLLLKRRRRAALFLLLALLGGGA-------LNTLLKLLVQRPRPPLH---------------------- 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320490  152 tknHERLLDGFrTTPSGHSSESFAGLGYLyFWLCGQLLTesplMPLWRKMVAFLPLLGAALIALSRTQDYRHHFVDVILG 231
Cdd:cd03392  94 ---LLVPEGGY-SFPSGHAMGATVLYGFL-AYLLARRLP----RRRVRILLLILAAILILLVGLSRLYLGVHYPSDVLAG 164


                ....*.
gi 6320490  232 SMLGYI 237
Cdd:cd03392 165 WLLGLA 170
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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