|
Name |
Accession |
Description |
Interval |
E-value |
| OAH_OAS_sulfhy |
TIGR01326 |
OAH/OAS sulfhydrylase; This model describes a distinct clade of the Cys/Met metabolism ... |
4-436 |
0e+00 |
|
OAH/OAS sulfhydrylase; This model describes a distinct clade of the Cys/Met metabolism pyridoxal phosphate-dependent enzyme superfamily. Members include examples of OAH/OAS sulfhydrylase, an enzyme with activity both as O-acetylhomoserine (OAH) sulfhydrylase (EC 2.5.1.49) and O-acetylserine (OAS) sulphydrylase (EC 2.5.1.47). An alternate name for OAH sulfhydrylase is homocysteine synthase. This model is designated subfamily because it may or may not have both activities. [Amino acid biosynthesis, Aspartate family, Amino acid biosynthesis, Serine family]
Pssm-ID: 273555 [Multi-domain] Cd Length: 418 Bit Score: 694.10 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 4 HFDTVQLHAGQENpgDNAHRSRAVPIYATTSYVFENSKHGSQLFGLEVPGYVYSRFQNPTSNVLEERIAALEGGAAALAV 83
Cdd:TIGR01326 1 HFETLQLHAGQEP--DPTTGSRAVPIYQTTSYVFDSTEHAAALFGLQEPGNIYSRLMNPTTDVLEQRIAALEGGVAALAV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 84 SSGQAAQTLAIQGLAHTGDNIVSTSYLYGGTYNQFKISFKRFGIEARFVEGDNPEEFEKVFDERTKAVYLETIGNPKYNV 163
Cdd:TIGR01326 79 ASGQAAITYAILNLAGAGDNIVSSSYLYGGTYNLFSHTLKRLGIEVRFVDPDDPESLEKAIDENTKAVFAETIGNPQINV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 164 PDFEKIVAIAHKHGIPVVVDNTFGAgGYFCQPIKYGADIVTHSATKWIGGHGTTIGGIIVDSGKFPWKDypEKFPQFSQP 243
Cdd:TIGR01326 159 LDIEAIAEVAHRHGIPLIVDNTFAT-PYLCRPIKHGADIVVHSATKYIGGHGTAIGGVIVDGGKFDWNN--GRFPLFTTP 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 244 AEGYHGTIYNEAYGNLAYIVHVRTELLRDLGPLMNPFASFLLLQGVETLSLRAERHGENALKLAKWLEQSPYVSWVSYPG 323
Cdd:TIGR01326 236 DPSYHGLVFTETLGNPAFILKARVQLLRDLGAALSPFNAFLLLQGLETLSLRMERHVENALKVAEFLESHPDVAWVNYPG 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 324 LASHSHHENAKKYLSNGFGGVLSFGVKDLPNADKEtdpfklsgaqVVDNLKLASNLANVGDAKTLVIAPYFTTHKQLNDK 403
Cdd:TIGR01326 316 LASHPHHALAKKYLPKGFGAVLSFEIKGGREAGKK----------FIDALKLASHLANVGDAKSLVIHPASTTHSQLSEE 385
|
410 420 430
....*....|....*....|....*....|...
gi 6323333 404 EKLASGVTKDLIRVSVGIEFIDDIIADFQQSFE 436
Cdd:TIGR01326 386 EQLKAGVTPGLIRLSVGIENIDDIIADLEQALE 418
|
|
| MET17 |
COG2873 |
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid ... |
4-438 |
0e+00 |
|
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid transport and metabolism]; O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent is part of the Pathway/BioSystem: Methionine biosynthesis
Pssm-ID: 442120 [Multi-domain] Cd Length: 428 Bit Score: 667.50 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 4 HFDTVQLHAGQEnPgDNAHRSRAVPIYATTSYVFENSKHGSQLFGLEVPGYVYSRFQNPTSNVLEERIAALEGGAAALAV 83
Cdd:COG2873 7 GFETLALHAGQE-P-DPTTGARAVPIYQTTSYVFDDAEHAADLFALKEPGNIYTRIMNPTTDVLEKRIAALEGGVAALAT 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 84 SSGQAAQTLAIQGLAHTGDNIVSTSYLYGGTYNQFKISFKRFGIEARFVEGDNPEEFEKVFDERTKAVYLETIGNPKYNV 163
Cdd:COG2873 85 ASGQAAITLAILNLAEAGDHIVASSSLYGGTYNLFAHTLPRLGIEVRFVDPDDPEAFEAAIDPNTKAIFGETIGNPALDV 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 164 PDFEKIVAIAHKHGIPVVVDNTFgAGGYFCQPIKYGADIVTHSATKWIGGHGTTIGGIIVDSGKFPWKDyPEKFPQFSQP 243
Cdd:COG2873 165 LDIEAIAEIAHEHGVPLIVDNTF-ATPYLCRPIEHGADIVVHSATKYIGGHGTSIGGVIVDGGNFDWAA-NGKFPELTEP 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 244 AEGYHGTIYNEAYGNLAYIVHVRTELLRDLGPLMNPFASFLLLQGVETLSLRAERHGENALKLAKWLEQSPYVSWVSYPG 323
Cdd:COG2873 243 DPSYHGLVYTEAFGNAAFITKARVQLLRDLGAALSPFNAFLLLQGLETLSLRMERHVENALKVAEFLEAHPKVAWVNYPG 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 324 LASHSHHENAKKYLSNGFGGVLSFGVKDlpnaDKEtdpfklSGAQVVDNLKLASNLANVGDAKTLVIAPYFTTHKQLNDK 403
Cdd:COG2873 323 LPSHPYHELAQKYLPKGAGGVLTFGLKG----GRE------AGKKFIDSLKLFSHLANIGDAKSLVIHPASTTHSQLSEE 392
|
410 420 430
....*....|....*....|....*....|....*
gi 6323333 404 EKLASGVTKDLIRVSVGIEFIDDIIADFQQSFETV 438
Cdd:COG2873 393 EQAAAGVTPDLIRLSVGIEDIDDIIADLDQALAAA 427
|
|
| PRK08248 |
PRK08248 |
homocysteine synthase; |
6-436 |
4.27e-170 |
|
homocysteine synthase;
Pssm-ID: 236201 [Multi-domain] Cd Length: 431 Bit Score: 484.35 E-value: 4.27e-170
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 6 DTVQLHAGQENpgDNAHRSRAVPIYATTSYVFENSKHGSQLFGLEVPGYVYSRFQNPTSNVLEERIAALEGGAAALAVSS 85
Cdd:PRK08248 10 ETLAIHAGQEI--DPTTGSRAVPIYQTTSYGFRDSEHAANLFSLKEFGNIYTRIMNPTTDVFEKRIAALEGGIGALAVSS 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 86 GQAAQTLAIQGLAHTGDNIVSTSYLYGGTYNQFKISFKRFGIEARFVEGDNPEEFEKVFDERTKAVYLETIGNPKYNVPD 165
Cdd:PRK08248 88 GQAAITYSILNIASAGDEIVSSSSLYGGTYNLFAHTLPKLGITVKFVDPSDPENFEAAITDKTKALFAETIGNPKGDVLD 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 166 FEKIVAIAHKHGIPVVVDNTFgAGGYFCQPIKYGADIVTHSATKWIGGHGTTIGGIIVDSGKFPWKDyPEKFPQFSQPAE 245
Cdd:PRK08248 168 IEAVAAIAHEHGIPLIVDNTF-ASPYLLRPIEHGADIVVHSATKFIGGHGTSIGGVIVDSGKFDWKG-SGKFPGLTEPDP 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 246 GYHGTIYNEAYGNLAYIVHVRTELLRDLGPLMNPFASFLLLQGVETLSLRAERHGENALKLAKWLEQSPYVSWVSYPGLA 325
Cdd:PRK08248 246 SYHGLVYTDAVGEAAYITKARVQLLRDLGAALSPFNSFLLLQGLETLHLRMERHSENALAVAKFLEEHEAVEWVSYPGLP 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 326 SHSHHENAKKYLSNGFGGVLSFGVKDLPNAdketdpfklsGAQVVDNLKLASNLANVGDAKTLVIAPYFTTHKQLNDKEK 405
Cdd:PRK08248 326 SHPSYELAKKYLPKGQGAILTFGIKGGVEA----------GKKLIDSVKLFSHLANVGDSKSLIIHPASTTHQQLSEEEQ 395
|
410 420 430
....*....|....*....|....*....|.
gi 6323333 406 LASGVTKDLIRVSVGIEFIDDIIADFQQSFE 436
Cdd:PRK08248 396 LAAGVTPGLVRLSVGTEAIDDILDDLRQAIR 426
|
|
| Cys_Met_Meta_PP |
pfam01053 |
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and ... |
6-436 |
4.30e-168 |
|
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and methionine metabolism. The following are members: Cystathionine gamma-lyase, Cystathionine gamma-synthase, Cystathionine beta-lyase, Methionine gamma-lyase, OAH/OAS sulfhydrylase, O-succinylhomoserine sulfhydrylase All of these members participate is slightly different reactions. All these enzymes use PLP (pyridoxal-5'-phosphate) as a cofactor.
Pssm-ID: 395837 [Multi-domain] Cd Length: 376 Bit Score: 477.11 E-value: 4.30e-168
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 6 DTVQLHAGQENpgDNAHRSRAVPIYATTSYVFEnskhgsqlFGLEVPGYVYSRFQNPTSNVLEERIAALEGGAAALAVSS 85
Cdd:pfam01053 1 DTLAVHAGQRP--DPQTGAVSVPIYLTSTYVFD--------FAGEEGGYDYSRSGNPTRDVLEERIAALEGGAAALAFSS 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 86 GQAAQTLAIQGLAHTGDNIVSTSYLYGGTYNQFKISFKRFGIEARFVEGDNPEEFEKVFDERTKAVYLETIGNPKYNVPD 165
Cdd:pfam01053 71 GMAAITAAILALLKAGDHIVATDDLYGGTYRLFNKVLPRFGIEVTFVDTSDPEDLEAAIKPNTKAVYLETPTNPLLKVVD 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 166 FEKIVAIAHKHGIPVVVDNTFGAgGYFCQPIKYGADIVTHSATKWIGGHGTTIGGIIVDSGkFPWKDYPEKFPqfsqpae 245
Cdd:pfam01053 151 IEAIAKLAKKHGILVVVDNTFAS-PYLQRPLDLGADIVVHSATKYIGGHSDVVGGVIVVNG-EELGKELYFLQ------- 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 246 gyhgtiyneaygnlayivhvrtellRDLGPLMNPFASFLLLQGVETLSLRAERHGENALKLAKWLEQSPYVSWVSYPGLA 325
Cdd:pfam01053 222 -------------------------NATGAVLSPFDAWLLLRGLKTLGLRMEQHQENAQKVAEFLESHPKVEKVYYPGLP 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 326 SHSHHENAKKYLSnGFGGVLSFGVKDLPNAdketdpfklsGAQVVDNLKLASNLANVGDAKTLVIAPYFTTHKQLNDKEK 405
Cdd:pfam01053 277 SHPGHELAKRQMK-GFGGMLSFELKGGLEA----------AKKFLDNLKLFSLAVSLGGVESLISHPATMTHASIPPEER 345
|
410 420 430
....*....|....*....|....*....|.
gi 6323333 406 LASGVTKDLIRVSVGIEFIDDIIADFQQSFE 436
Cdd:pfam01053 346 EAAGITDDLIRLSVGIEDVDDLIADLKQALE 376
|
|
| PRK07812 |
PRK07812 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
4-435 |
1.13e-160 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 236105 Cd Length: 436 Bit Score: 460.37 E-value: 1.13e-160
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 4 HFDTVQLHAGQEnpGDNAHRSRAVPIYATTSYVFENSKHGSQLFGLEVPGYVYSRFQNPTSNVLEERIAALEGGAAALAV 83
Cdd:PRK07812 13 SFETKQIHAGQT--PDPATNARALPIYQTTSYTFDDTDHAAALFGLAEPGNIYTRIMNPTQDVVEQRIAALEGGVAALLL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 84 SSGQAAQTLAIQGLAHTGDNIVSTSYLYGGTYNQFKISFKRFGIEARFVEG-DNPEEFEKVFDERTKAVYLETIGNPKYN 162
Cdd:PRK07812 91 ASGQAAETFAILNLAGAGDHIVSSPRLYGGTYNLFHYTLPKLGIEVSFVEDpDDLDAWRAAVRPNTKAFFAETISNPQID 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 163 VPDFEKIVAIAHKHGIPVVVDNTFgAGGYFCQPIKYGADIVTHSATKWIGGHGTTIGGIIVDSGKFPWKDypEKFPQFSQ 242
Cdd:PRK07812 171 VLDIPGVAEVAHEAGVPLIVDNTI-ATPYLIRPLEHGADIVVHSATKYLGGHGTAIAGVIVDGGTFDWTQ--GRFPGFTT 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 243 PAEGYHGTIYNEaYGNLAYIVHVRTELLRDLGPLMNPFASFLLLQGVETLSLRAERHGENALKLAKWLEQSPYVSWVSYP 322
Cdd:PRK07812 248 PDPSYHGVVFAE-LGPPAYALKARVQLLRDLGSAISPFNAFLIAQGLETLSLRIERHVANAQRVAEFLEARDEVASVNYA 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 323 GLASHSHHENAKKYLSNGFGGVLSFGVKDLPNAdketdpfklsGAQVVDNLKLASNLANVGDAKTLVIAPYFTTHKQLND 402
Cdd:PRK07812 327 GLPSSPWYERAKRLAPKGTGAVLSFELAGGVEA----------GKAFVNALTLHSHVANIGDVRSLVIHPASTTHSQLTP 396
|
410 420 430
....*....|....*....|....*....|...
gi 6323333 403 KEKLASGVTKDLIRVSVGIEFIDDIIADFQQSF 435
Cdd:PRK07812 397 EEQLATGVTPGLVRLAVGIEGIDDILADLEAGF 429
|
|
| PRK06084 |
PRK06084 |
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; |
6-440 |
9.54e-158 |
|
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
Pssm-ID: 180392 [Multi-domain] Cd Length: 425 Bit Score: 452.82 E-value: 9.54e-158
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 6 DTVQLHAGQeNPgDNAHRSRAVPIYATTSYVFENSKHGSQLFGLEVPGYVYSRFQNPTSNVLEERIAALEGGAAALAVSS 85
Cdd:PRK06084 4 ETLAIHAGY-SP-DPTTKAVAVPIYQTTSYAFDDTQHGADLFDLKVPGNIYTRIMNPTNDVLEQRVAALEGGVGALAVAS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 86 GQAAQTLAIQGLAHTGDNIVSTSYLYGGTYNQFKISFKRFGIEARFVEGDNPEEFEKVFDERTKAVYLETIGNPKYNVPD 165
Cdd:PRK06084 82 GMAAITYAIQTIAEAGDNIVSVAKLYGGTYNLLAHTLPRIGIETRFAAHDDIAALEALIDERTKAVFCESIGNPAGNIID 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 166 FEKIVAIAHKHGIPVVVDNTFgAGGYFCQPIKYGADIVTHSATKWIGGHGTTIGGIIVDSGKFPWKDYPEKFPQFSQPAE 245
Cdd:PRK06084 162 IQALADAAHRHGVPLIVDNTV-ATPVLCRPFEHGADIVVHSLTKYIGGHGTSIGGIVVDSGKFPWAEHKERFALLNTPDP 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 246 GYHGTIYNEAYGNLAYIVHVRTELLRDLGPLMNPFASFLLLQGVETLSLRAERHGENALKLAKWLEQSPYVSWVSYPGLA 325
Cdd:PRK06084 241 SYHGVTYTEAFGPAAFIGRCRVVPLRNMGAALSPFNAFLILQGLETLALRMERHTENALKVARYLQQHPQVAWVKYAGLP 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 326 SHSHHENAKKYLSNGFGGVLSFGVKDLPNAdketdpfklsGAQVVDNLKLASNLANVGDAKTLVIAPYFTTHKQLNDKEK 405
Cdd:PRK06084 321 DHPEHELARRYMGGKPASILSFGIKGGQAA----------GARFIDALKLVVRLVNIGDAKSLACHPASTTHRQLNDEEL 390
|
410 420 430
....*....|....*....|....*....|....*
gi 6323333 406 LASGVTKDLIRVSVGIEFIDDIIADFQQSFETVFA 440
Cdd:PRK06084 391 EKAGVSRDMVRLSIGIEHIDDIIADLAQALDASKG 425
|
|
| PRK05994 |
PRK05994 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
5-438 |
3.77e-155 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 180344 [Multi-domain] Cd Length: 427 Bit Score: 446.08 E-value: 3.77e-155
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 5 FDTVQLHAG-QENPGDNAhrsRAVPIYATTSYVFENSKHGSQLFGLEVPGYVYSRFQNPTSNVLEERIAALEGGAAALAV 83
Cdd:PRK05994 8 FATLAVHAGaQPDPTTGA---RATPIYQTTSFVFNDADHAASLFGLQAFGNIYTRITNPTNAVLEERVAALEGGTAALAV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 84 SSGQAAQTLAIQGLAHTGDNIVSTSYLYGGTYNQFKISFKRFGIEARFVEGDNPEEFEKVFDERTKAVYLETIGNPKYNV 163
Cdd:PRK05994 85 ASGHAAQFLVFHTLLQPGDEFIAARKLYGGSINQFGHAFKSFGWQVRWADADDPASFERAITPRTKAIFIESIANPGGTV 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 164 PDFEKIVAIAHKHGIPVVVDNTFgAGGYFCQPIKYGADIVTHSATKWIGGHGTTIGGIIVDSGKFPWKDyPEKFPQFSQP 243
Cdd:PRK05994 165 TDIAAIAEVAHRAGLPLIVDNTL-ASPYLIRPIEHGADIVVHSLTKFLGGHGNSMGGIIVDGGTFDWSK-SGKYPMLSEP 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 244 AEGYHGTIYNEAYGNLAYIVHVRTELLRDLGPLMNPFASFLLLQGVETLSLRAERHGENALKLAKWLEQSPYVSWVSYPG 323
Cdd:PRK05994 243 RPEYHGLVLHETFGNFAFAIAARVLGLRDLGPAISPFNAFLILTGIETLPLRMQRHSDNALAVAEWLKGHPKVSWVNYAG 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 324 LASHSHHENAKKYLSNGFGGVLSFGVKDLPNAdketdpfklsGAQVVDNLKLASNLANVGDAKTLVIAPYFTTHKQLNDK 403
Cdd:PRK05994 323 LPDDPYHALAQKYSPKGAGAVFTFGLKGGYEA----------GVKLVSSLKLFSHLANIGDTRSLVIHPASTTHRQLTDE 392
|
410 420 430
....*....|....*....|....*....|....*
gi 6323333 404 EKLASGVTKDLIRVSVGIEFIDDIIADFQQSFETV 438
Cdd:PRK05994 393 QKVAAGAGPDVVRLSIGIEDVDDIIADLEQALAKA 427
|
|
| CGS_like |
cd00614 |
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed ... |
24-436 |
2.80e-145 |
|
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of antimicrobials and herbicides. This subgroup also includes cystathionine gamma-lyases (CGL), O-acetylhomoserine sulfhydrylases and O-acetylhomoserine thiol lyases. CGL's are very similar to CGS's. Members of this group are widely distributed among all three forms of life.
Pssm-ID: 99738 [Multi-domain] Cd Length: 369 Bit Score: 418.91 E-value: 2.80e-145
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 24 SRAVPIYATTSYVFENSKHGSQLFGLEVPGYVYSRFQNPTSNVLEERIAALEGGAAALAVSSGQAAQTLAIQGLAHTGDN 103
Cdd:cd00614 2 AVAPPIYQTSTFVFPSPAEAADLFALREGGYIYSRIGNPTVDALEKKLAALEGGEAALAFSSGMAAISTVLLALLKAGDH 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 104 IVSTSYLYGGTYNQFKISFKRFGIEARFVEGDNPEEFEKVFDERTKAVYLETIGNPKYNVPDFEKIVAIAHKHGIPVVVD 183
Cdd:cd00614 82 VVASDDLYGGTYRLFERLLPKLGIEVTFVDPDDPEALEAAIKPETKLVYVESPTNPTLKVVDIEAIAELAHEHGALLVVD 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 184 NTFgAGGYFCQPIKYGADIVTHSATKWIgghgttiggiivdsgkfpwkdypekfpqfsqpaeGYH-----GTIyneAYGN 258
Cdd:cd00614 162 NTF-ATPYLQRPLELGADIVVHSATKYI----------------------------------GGHsdviaGVV---VGSG 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 259 LAYIVHVRTELLRdLGPLMNPFASFLLLQGVETLSLRAERHGENALKLAKWLEQSPYVSWVSYPGLASHSHHENAKKYLS 338
Cdd:cd00614 204 EALIQRLRFLRLA-LGTILSPFDAWLLLRGLKTLPLRMERHSENALKVAEFLEKHPKVERVYYPGLPSHPQHELAKKQMS 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 339 nGFGGVLSFGVKDlpnADKETDPFklsgaqvVDNLKLASNLANVGDAKTLVIAPYFTTHKQLNDKEKLASGVTKDLIRVS 418
Cdd:cd00614 283 -GYGGVFSFELKG---GLEAAKKF-------LNALKLFSLAVSLGGVESLVEHPASMTHSQLPPEERAAAGITPGLVRLS 351
|
410
....*....|....*...
gi 6323333 419 VGIEFIDDIIADFQQSFE 436
Cdd:cd00614 352 VGIEDVEDLIADLEQALK 369
|
|
| PRK08134 |
PRK08134 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
2-434 |
1.18e-142 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 236159 Cd Length: 433 Bit Score: 414.52 E-value: 1.18e-142
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 2 PSHFDTVQLHAGQenPGDNAHRSRAVPIYATTSYVFENSKHGSQLFGLEVPGYVYSRFQNPTSNVLEERIAALEGGAAAL 81
Cdd:PRK08134 6 PPGFDTLALHAGA--APDPATGARAVPIHLTTSFVFRDSDHAAALFNLERAGHVYSRISNPTVAVLEERVAALEGGVGAI 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 82 AVSSGQAAQTLAIQGLAHTGDNIVSTSYLYGGTYNQFKISFKRFGIEARFVEGDNPEEFEKVFDERTKAVYLETIGNPKY 161
Cdd:PRK08134 84 ATASGQAALHLAIATLMGAGSHIVASSALYGGSHNLLHYTLRRFGIETTFVKPGDIDGWRAAIRPNTRLLFGETLGNPGL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 162 NVPDFEKIVAIAHKHGIPVVVDNTFgAGGYFCQPIKYGADIVTHSATKWIGGHGTTIGGIIVDSGKFPWkDYPEKFPQFS 241
Cdd:PRK08134 164 EVLDIPTVAAIAHEAGVPLLVDSTF-TTPYLLRPFEHGADLVYHSATKFLGGHGTAIGGVLVDGGRFDW-EASGKFPELT 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 242 QPAEGYHGTIYNEAYGNLAYIVHVRTELLRDLGPLMNPFASFLLLQGVETLSLRAERHGENALKLAKWLEQSPYVSWVSY 321
Cdd:PRK08134 242 EPYAGFHGMVFAEESTVAAFLLRARREGLRDFGACLSPMNAWQLLQGIETLPLRMERHVANTRKVVAFLASHPAVARVAH 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 322 PGLASHSHHENAKKYLSNGFGGVLSFGVKdlpnADKEtdpfklSGAQVVDNLKLASNLANVGDAKTLVIAPYFTTHKQLN 401
Cdd:PRK08134 322 PELESHPDHALAKRLLPRGAGSVFSFDLK----GGRA------AGRKFIESLKLFSHLANVGDARSLVIHPASTTHFRMD 391
|
410 420 430
....*....|....*....|....*....|...
gi 6323333 402 DKEKLASGVTKDLIRVSVGIEFIDDIIADFQQS 434
Cdd:PRK08134 392 AAALAAAGIGEGTIRLSIGLEDADDLIDDLKRA 424
|
|
| MetC |
COG0626 |
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; ... |
4-438 |
1.39e-126 |
|
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; Cystathionine beta-lyase/cystathionine gamma-synthase is part of the Pathway/BioSystem: Methionine biosynthesis
Pssm-ID: 440391 [Multi-domain] Cd Length: 389 Bit Score: 372.07 E-value: 1.39e-126
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 4 HFDTVQLHAGQEnpGDNAHRSRAVPIYATTSYVFENSKHGSQLFGLEVPGYVYSRFQNPTSNVLEERIAALEGGAAALAV 83
Cdd:COG0626 2 GPATRAVHAGRD--PDPQTGAVSPPIYLTSTFVFPSAEALAARFAGEEGGYIYSRYGNPTRRALEEALAALEGGEAALAF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 84 SSGQAAQTLAIQGLAHTGDNIVSTSYLYGGTYNQFKISFKRFGIEARFVEGDNPEEFEKVFDERTKAVYLETIGNPKYNV 163
Cdd:COG0626 80 ASGMAAISAVLLALLKAGDHVVASDDLYGGTRRLLDKVLARFGIEVTFVDPTDLAAVEAAIRPNTKLVFLETPSNPTLEV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 164 PDFEKIVAIAHKHGIPVVVDNTFgAGGYFCQPIKYGADIVTHSATKWIgghgttiggiivdSGkfpwkdypekfpqfsqp 243
Cdd:COG0626 160 VDIAAIAAIAHAAGALLVVDNTF-ATPLLQRPLELGADIVVHSATKYL-------------GG----------------- 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 244 aegyHGTIyneaygnLAYIVHVRTELL--------RDLGPLMNPFASFLLLQGVETLSLRAERHGENALKLAKWLEQSPY 315
Cdd:COG0626 209 ----HSDV-------LGGAVVGRDEELaerlrflqNALGAVLSPFDAWLLLRGLKTLALRMERHCENALAVAEWLEAHPA 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 316 VSWVSYPGLASHSHHENAKKYLSnGFGGVLSFGVKDlpnaDKETdpfklsGAQVVDNLKLASNLANVGDAKTLVIAPYFT 395
Cdd:COG0626 278 VARVYYPGLPSHPGHELAKRQMS-GFGGMLSFELKG----GREA------ARRFLDALKLFTLAVSLGGVESLITHPATM 346
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 6323333 396 THKQLNDKEKLASGVTKDLIRVSVGIEFIDDIIADFQQSFETV 438
Cdd:COG0626 347 THRSLPPEERAALGITDGLVRLSVGLEDVDDLIADLEQALAAL 389
|
|
| PRK05613 |
PRK05613 |
O-acetylhomoserine/O-acetylserine sulfhydrylase; |
5-438 |
1.82e-113 |
|
O-acetylhomoserine/O-acetylserine sulfhydrylase;
Pssm-ID: 168128 [Multi-domain] Cd Length: 437 Bit Score: 340.31 E-value: 1.82e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 5 FDTVQLHAGQenPGDNAHRSRAVPIYATTSYVFENSKHGSQLFGLEVPGYVYSRFQNPTSNVLEERIAALEGGAAALAVS 84
Cdd:PRK05613 14 FETRSIHAGQ--SVDSDTSARNLPIYQTTSYVFDSAEHAKQRFALEDLGPIYSRLTNPTVEALENRIASLEGGVHAVAFA 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 85 SGQAAQTLAIQGLAHTGDNIVSTSYLYGGTYNQFKISFKRFGIEARFVEG-DNPEEFEKVFDERTKAVYLETIGNPKYNV 163
Cdd:PRK05613 92 SGQAAETAAILNLAGAGDHIVTSPRLYGGTETLFLVTLNRLGIEVTFVENpDDPESWQAAVQPNTKAFFGETFANPQADV 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 164 PDFEKIVAIAHKHGIPVVVDNTFgAGGYFCQPIKYGADIVTHSATKWIGGHGTTIGGIIVDSGKFPW---KDYPEKFPQF 240
Cdd:PRK05613 172 LDIPAVAEVAHRNQVPLIVDNTI-ATAALVRPLELGADVVVASLTKFYTGNGSGLGGVLIDGGKFDWtveRDGKPVFPYF 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 241 SQPAEGYHGTIYNEaYGNLAYIVHVRTELLRDLGPLMNPFASFLLLQGVETLSLRAERHGENALKLAKWLEQSPYVSWVS 320
Cdd:PRK05613 251 VTPDPAYHGLKYAD-LGAPAFGLKARAGLLRDTGATLSPFNAWVTAQGLDTLSLRLERHNENAIKVAEFLNNHEKVAKVN 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 321 YPGLASHSHHENAKKYLSNGFGGVLSFgvkDLPNADKETDPFklsgaqvVDNLKLASNLANVGDAKTLVIAPYFTTHKQL 400
Cdd:PRK05613 330 FAGLKDSPWYATKEKLGLKYTGSVLSF---DIKGGKDEAWAF-------IDALKLHSNLANIGDVRSLVVHPATTTHSQS 399
|
410 420 430
....*....|....*....|....*....|....*...
gi 6323333 401 NDKEKLASGVTKDLIRVSVGIEFIDDIIADFQQSFETV 438
Cdd:PRK05613 400 DEAGLARAGITQATVRLSVGIEDIDDIIADLEGGFAAI 437
|
|
| PRK06702 |
PRK06702 |
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; |
25-435 |
2.04e-101 |
|
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
Pssm-ID: 102505 [Multi-domain] Cd Length: 432 Bit Score: 309.29 E-value: 2.04e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 25 RAVPIYATTSYVFENSKHGSQLFGLEVPGYVYSRFQNPTSNVLEERIAALEGGAAALAVSSGQAAQTLAIQGLAHTGDNI 104
Cdd:PRK06702 24 RVLPLYQSTTYKYDTSDDLAALFNLEAEGYIYTRIGNPTLAAFEQKLAELEGGVGAVATASGQAAIMLAVLNICSSGDHL 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 105 VSTSYLYGGTYNQFKISFKRFGIEARFVEGD-NPEEFEKVFDERTKAVYLETIGNPKYNVPDFEKIVAIAHKHGIPVVVD 183
Cdd:PRK06702 104 LCSSTVYGGTFNLFGVSLRKLGIDVTFFNPNlTADEIVALANDKTKLVYAESLGNPAMNVLNFKEFSDAAKELEVPFIVD 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 184 NTFgAGGYFCQPIKYGADIVTHSATKWIGGHGTTIGGIIVDSGKFPWKDypEKFPQFSQPAEGYHGTIYNEAYGNLAYIV 263
Cdd:PRK06702 184 NTL-ATPYLCQAFEHGANIIVHSTTKYIDGHASSLGGIVIDGGNFDWTN--GKYPELVEPDPSYHGVSYVQNFGAAAYIV 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 264 HVRTELLRDLGPLMNPFASFLLLQGVETLSLRAERHGENALKLAKWLEQSPYVSWVSYPGLASHSHHENAKKYLSNGFGG 343
Cdd:PRK06702 261 KARVQLLRDYGNCMSPFNAYISNIGLETLHLRMERHSENALAVAKWLADHERIEWVNYPGLDSNENYSLAQKYLKKGASG 340
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 344 VLSFGVKDLPNADKEtdpfklsgaqVVDNLKLASNLANVGDAKTLVIAPYFTTHKQLNDKEKLASGVTKDLIRVSVGIEF 423
Cdd:PRK06702 341 VLTFGIKGGLEAAKE----------FIANVKLATLVTHVADARTCVIHPASTTHRQLSAEDQRLAGVTSDLIRLSVGIED 410
|
410
....*....|..
gi 6323333 424 IDDIIADFQQSF 435
Cdd:PRK06702 411 VSDIIADLEAAL 422
|
|
| PRK08133 |
PRK08133 |
O-succinylhomoserine sulfhydrylase; Validated |
4-430 |
2.58e-100 |
|
O-succinylhomoserine sulfhydrylase; Validated
Pssm-ID: 181244 [Multi-domain] Cd Length: 390 Bit Score: 305.00 E-value: 2.58e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 4 HFDTVQLHAGQENPGDNAHrsrAVPIYATTSYVFENSKHGSQLFGLEVPGYVYSRFQNPTSNVLEERIAALEGGAAALAV 83
Cdd:PRK08133 6 GFDTLAVRAGQLRSPFGEH---SEALFLTSSFVFESAAEAAARFAGEEPGNIYSRFTNPTVTMFQERLAALEGAEACVAT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 84 SSGQAAQTLAIQGLAHTGDNIVSTSYLYGGTYNQFKISFKRFGIEARFVEGDNPEEFEKVFDERTKAVYLETIGNPKYNV 163
Cdd:PRK08133 83 ASGMAAILAVVMALLQAGDHVVSSRSLFGSTVSLFEKIFARFGIETTFVDLTDLDAWRAAVRPNTKLFFLETPSNPLTEL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 164 PDFEKIVAIAHKHGIPVVVDNTfgaggyFC-----QPIKYGADIVTHSATKWIGGHGTTIGGIIVDSGKFpwkdypekfp 238
Cdd:PRK08133 163 ADIAALAEIAHAAGALLVVDNC------FCtpalqQPLKLGADVVIHSATKYLDGQGRVLGGAVVGSKEL---------- 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 239 qfsqpaegyhgtiYNEAYGnlayivhvrteLLRDLGPLMNPFASFLLLQGVETLSLRAERHGENALKLAKWLEQSPYVSW 318
Cdd:PRK08133 227 -------------MEEVFG-----------FLRTAGPTLSPFNAWVFLKGLETLSLRMEAHSANALALAEWLEAHPGVER 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 319 VSYPGLASHSHHENAKKYLSnGFGGVLSFGVKdlpnADKEtdpfklsGA-QVVDNLKLASNLANVGDAKTLVIAPYFTTH 397
Cdd:PRK08133 283 VFYPGLPSHPQHELAKRQQK-GGGAIVSFEVK----GGRE-------AAwRVIDATRLISITANLGDTKTTITHPATTTH 350
|
410 420 430
....*....|....*....|....*....|...
gi 6323333 398 KQLNDKEKLASGVTKDLIRVSVGIEFIDDIIAD 430
Cdd:PRK08133 351 GRLSPEARAAAGITEGLIRVAVGLEDVADIKAD 383
|
|
| O_suc_HS_sulf |
TIGR01325 |
O-succinylhomoserine sulfhydrylase; This model describes O-succinylhomoserine sulfhydrylase, ... |
6-434 |
3.27e-94 |
|
O-succinylhomoserine sulfhydrylase; This model describes O-succinylhomoserine sulfhydrylase, one of several related pyridoxal phosphate-dependent enzymes of cysteine and methionine metabolism. This enzyme is part of an alternative pathway of homocysteine biosynthesis, a step in methionine biosynthesis. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 188131 Cd Length: 381 Bit Score: 289.05 E-value: 3.27e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 6 DTVQLHAGQENPGDNAHrsrAVPIYATTSYVFENSKHGSQLFGLEVPGYVYSRFQNPTSNVLEERIAALEGGAAALAVSS 85
Cdd:TIGR01325 1 ATLAVRGGMLRSGFEET---AEALYLTSGYVYDSAAVAAKRFAGELPGFVYSRYGNPTVSVFEERLALLEGAEAAVATAS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 86 GQAAQTLAIQGLAHTGDNIVSTSYLYGGTYNQFKISFKRFGIEARFVEGDNPEEFEKVFDERTKAVYLETIGNPKYNVPD 165
Cdd:TIGR01325 78 GMAAIFAALMALLGAGDHVVASRSLFGSCFVVCSEILPRFGVQTVFVDGTDLSAWEAALKPNTKAVFVETPSNPLQELVD 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 166 FEKIVAIAHKHGIPVVVDNTFgAGGYFCQPIKYGADIVTHSATKwigghgttiggiIVDSgkfpwkdypekfpqfsqpae 245
Cdd:TIGR01325 158 IAAVAELAHAAGAKVVVDNVF-ATPLLQQPLKLGADVVVYSATK------------HIDG-------------------- 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 246 gyHGTIYNEAY-GNLAYIVHVRTELLRDLGPLMNPFASFLLLQGVETLSLRAERHGENALKLAKWLEQSPYVSWVSYPGL 324
Cdd:TIGR01325 205 --QGRVLGGAIlGSEEYMDEPVQKLLRHTGPAMSPFNAWVLLKGLETLAIRVQHQNASALAIAEWLNGHPSVQWVYYPGL 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 325 ASHSHHENAKKYLSnGFGGVLSFGVKDLPNADKetdpfklsgaqVVDNLKLASNLANVGDAKTLVIAPYFTTHKQLNDKE 404
Cdd:TIGR01325 283 PSHPQHELAKRQMS-GGGTVVTFDLDCRQAAFK-----------VLDAMRLVDISNNLGDAKSTITHPATTTHRRMGPEE 350
|
410 420 430
....*....|....*....|....*....|
gi 6323333 405 KLASGVTKDLIRVSVGIEFIDDIIADFQQS 434
Cdd:TIGR01325 351 RAAAGIGDGLVRLSVGLEDVDDLIADIDRA 380
|
|
| PRK06234 |
PRK06234 |
methionine gamma-lyase; Provisional |
1-438 |
1.30e-93 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 168478 [Multi-domain] Cd Length: 400 Bit Score: 288.26 E-value: 1.30e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 1 MPSHFDTVQLHAGqeNPGDNAHRSRAVPIYATTSYVFENSKHGSQLFGLEVPGYVYSRFQNPTSNVLEERIAALEGGAAA 80
Cdd:PRK06234 5 KKMGFATKAIHGG--HIGDKQFGSLATPIYQTSTFIFDSAEQGGRRFAGEESGYIYSRLGNPTSTEVENKLALLEGGEAA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 81 LAVSSGQAAQTLAIQGLAHTGDNIVSTSYLYGGTYNQFKISFKRFGIEARFVEGDNPEEFEKVFDERTKAVYLETIGNPK 160
Cdd:PRK06234 83 VVAASGMGAISSSLWSALKAGDHVVASDTLYGCTFALLNHGLTRYGVEVTFVDTSNLEEVRNALKANTKVVYLETPANPT 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 161 YNVPDFEKIVAIAHKH--GIPVVVDNTFgAGGYFCQPIKYGADIVTHSATKWIgghgttiggiivdsgkfpwkdypekfp 238
Cdd:PRK06234 163 LKVTDIKAISNIAHENnkECLVFVDNTF-CTPYIQRPLQLGADVVVHSATKYL--------------------------- 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 239 qfsqpaEGYHGTIYNEAYGNLAYIVHVRTELLRDL-GPLMNPFASFLLLQGVETLSLRAERHGENALKLAKWLEQSPYVS 317
Cdd:PRK06234 215 ------NGHGDVIAGFVVGKEEFINQVKLFGIKDMtGSVIGPFEAFLIIRGMKTLQIRMEKHCKNAMKVAKFLESHPAVE 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 318 WVSYPGLASHSHHENAKKYLSNgFGGVLSFGVKDLPNAdketdpfklsGAQVVDNLKLASNLANVGDAKTLVIAPYFTTH 397
Cdd:PRK06234 289 KVYYPGLESFEYYELAKKQMSL-PGAMISFELKGGVEE----------GKVVMNNVKLATLAVSLGDAETLIQHPASMTH 357
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 6323333 398 KQLNDKEKLASGVTKDLIRVSVGIEFIDDIIADFQQSFETV 438
Cdd:PRK06234 358 SPYTAEERKEAGISDGLVRLSVGLEDVDDIIADLKQALDLI 398
|
|
| met_gam_lyase |
TIGR01328 |
methionine gamma-lyase; This model describes a methionine gamma-lyase subset of a family of ... |
4-436 |
9.66e-91 |
|
methionine gamma-lyase; This model describes a methionine gamma-lyase subset of a family of PLP-dependent trans-sulfuration enzymes. The member from the parasite Trichomonas vaginalis is described as catalyzing alpha gamma- and alpha-beta eliminations and gamma-replacement reactions on methionine, cysteine, and some derivatives. Likewise, the enzyme from Pseudomonas degrades cysteine as well as methionine. [Energy metabolism, Amino acids and amines]
Pssm-ID: 130395 [Multi-domain] Cd Length: 391 Bit Score: 280.24 E-value: 9.66e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 4 HFDTVQLHAGQEnPGDNaHRSRAVPIYATTSYVFENSKHGSQLFGLEVPGYVYSRFQNPTSNVLEERIAALEGGAAALAV 83
Cdd:TIGR01328 3 TFATRAIHAGYP-PKDQ-FGALTPPIYQTSTFVFDSCEQGGNRFAGQESGYIYSRLGNPTVSNLEGRIAFLEGTEAAVAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 84 SSGQAAQTLAIQGLAHTGDNIVSTSYLYGGTYNQFKISFKRFGIEARFVEGDNPEEFEKVFDERTKAVYLETIGNPKYNV 163
Cdd:TIGR01328 81 SSGMGAIAATLLTILKAGDHLISDECLYGCTFALLEHALTKFGIQVDFINMAIPEEVKAHIKDNTKIVYFETPANPTMKL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 164 PDFEKIVAIAHKHGIPVVVDNTFgAGGYFCQPIKYGADIVTHSATKWIgghgttiggiivdsgkfpwkdypekfpqfsqp 243
Cdd:TIGR01328 161 IDMERVCRDAHSQGVKVIVDNTF-ATPMLTNPVALGVDVVVHSATKYI-------------------------------- 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 244 aeGYHG-TIYNEAYGNLAYIVHVRTELLRDL-GPLMNPFASFLLLQGVETLSLRAERHGENALKLAKWLEQSPYVSWVSY 321
Cdd:TIGR01328 208 --GGHGdVVAGLICGKAELLQQIRMVGIKDMtGSVISPFDAWLILRGLKTLNIRMKRHSENAMKVAEYLKSHPAVEKVYY 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 322 PGLASHSHHENAKKYLSNGfGGVLSFGVKDLPNAdketdpfklsGAQVVDNLKLASNLANVGDAKTLVIAPYFTTHKQLN 401
Cdd:TIGR01328 286 PGFEDHPGHDIAAKQMRMG-GGMITFELKGGFAG----------AKKLLNNLKLIRLAVSLGDAETLIQHPASMTHAVVP 354
|
410 420 430
....*....|....*....|....*....|....*
gi 6323333 402 DKEKLASGVTKDLIRVSVGIEFIDDIIADFQQSFE 436
Cdd:TIGR01328 355 KEEREAAGITDGMIRLSVGLEDADDLIADLKQALD 389
|
|
| PRK07503 |
PRK07503 |
methionine gamma-lyase; Provisional |
5-436 |
5.40e-81 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 181005 [Multi-domain] Cd Length: 403 Bit Score: 255.50 E-value: 5.40e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 5 FDTVQLHAGQeNPGDNaHRSRAVPIYATTSYVFENSKHGSQLFGLEVPGYVYSRFQNPTSNVLEERIAALEGGAAALAVS 84
Cdd:PRK07503 10 FSTRAIHHGY-DPLDH-GGALVPPVYLTATFAFPTAEYGAECFAGEEEGHFYSRISNPTLALLEQRMASLEGGEAAVALA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 85 SGQAAQTLAIQGLAHTGDNIVSTSYLYGGTYNQFKISFKRFGIEARFVEGDNPEEFEKVFDERTKAVYLETIGNPKYNVP 164
Cdd:PRK07503 88 SGMGAITATLWTLLRPGDEVIVDQTLYGCTFAFLHHGLGEFGVTVRHVDLTDPAALKAAISDKTRMVYFETPANPNMRLV 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 165 DFEKIVAIAHKHGIPVVVDNTFgAGGYFCQPIKYGADIVTHSATKWIgghgttiggiivdsgkfpwkdypekfpqfsqpa 244
Cdd:PRK07503 168 DIAAVAEIAHGAGAKVVVDNTY-CTPYLQRPLELGADLVVHSATKYL--------------------------------- 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 245 eGYHGTIY-NEAYGNLAYIVHVRTELLRDL-GPLMNPFASFLLLQGVETLSLRAERHGENALKLAKWLEQSPYVSWVSYP 322
Cdd:PRK07503 214 -GGHGDITaGLVVGGKALADRIRLEGLKDMtGAVMSPFDAFLLMRGLKTLALRMDRHCASAQAVAEWLARHPAVELVHYP 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 323 GLASHSHHENAKKYLSNGfGGVLSFGVKDLPNAdketdpfklsGAQVVDNLKLASNLANVGDAKTLVIAPYFTTHKQLND 402
Cdd:PRK07503 293 GLPSFAQHALAQRQMALP-GGMIAFELKGGIAA----------GRRFMNALQLFARAVSLGDAESLAQHPASMTHSTYTP 361
|
410 420 430
....*....|....*....|....*....|....
gi 6323333 403 KEKLASGVTKDLIRVSVGIEFIDDIIADFQQSFE 436
Cdd:PRK07503 362 EERAEHGISEGLVRLSVGLEDVADILADLAQALD 395
|
|
| PRK06767 |
PRK06767 |
methionine gamma-lyase; Provisional |
3-438 |
9.64e-80 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 180685 [Multi-domain] Cd Length: 386 Bit Score: 252.07 E-value: 9.64e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 3 SHFDTVQLHAGQENpgdNAHR-SRAVPIYATTSYVFENSKHGSQLFGLEVPGYVYSRFQNPTSNVLEERIAALEGGAAAL 81
Cdd:PRK06767 4 KHMETALIHHGYTS---EEHKgSLTPPLFQTSTFTFETAQQGEASFAGVDPSYIYSRLGNPTVKLFEERMAVLEGGEEAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 82 AVSSGQAAQTLAIQGLAHTGDNIVSTSYLYGGTYNQFKISFKRFGIEARFVEGDNPEEFEKVFDERTKAVYLETIGNPKY 161
Cdd:PRK06767 81 AFGSGMAAISATLIGFLKAGDHIICSNGLYGCTYGFLEVLEEKFMITHSFCDMETEADIENKIRPNTKLIFVETPINPTM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 162 NVPDFEKIVAIAHKHGIPVVVDNTFgAGGYFCQPIKYGADIVTHSATKWIgghgttiggiivdsgkfpwkdypekfpqfs 241
Cdd:PRK06767 161 KLIDLKQVIRVAKRNGLLVIVDNTF-CSPYLQRPLELGCDAVVHSATKYI------------------------------ 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 242 qpaeGYHG-TIYNEAYGNLAYIVHVRTELLRDLGPLMNPFASFLLLQGVETLSLRAERHGENALKLAKWLEQSPYVSWVS 320
Cdd:PRK06767 210 ----GGHGdVVAGVTICKTRALAEKIRPMRKDIGGIMAPFDAWLLLRGLKTLAVRMDRHCDNAEKIVSFLKNHDAVEGVW 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 321 YPglashsHHENAKKYLSNGfGGVLSFGVKdlpNADKETdpfklsgAQVVDNLKLASNLANVGDAKTLVIAPYFTTHKQL 400
Cdd:PRK06767 286 YP------EGELASRQMKRG-GGVISFSIK---GGKEET-------QAFINDLHFITIAVSLGDTETLIQHPATMTHAAI 348
|
410 420 430
....*....|....*....|....*....|....*...
gi 6323333 401 NDKEKLASGVTKDLIRVSVGIEFIDDIIADFQQSFETV 438
Cdd:PRK06767 349 PAELRQEMGIYDNLIRLSVGLESWEDIVSDLEQALKKI 386
|
|
| PRK07810 |
PRK07810 |
O-succinylhomoserine sulfhydrylase; Provisional |
6-435 |
4.27e-76 |
|
O-succinylhomoserine sulfhydrylase; Provisional
Pssm-ID: 236103 [Multi-domain] Cd Length: 403 Bit Score: 243.10 E-value: 4.27e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 6 DTVQLHAGQENPGdnaHRSRAVPIYATTSYVFENSKHGSQLFGLEVPGYVYSRFQNPTSNVLEERIAALEGGAAALAVSS 85
Cdd:PRK07810 17 ATIGVRGGLLRSG---FEETAEALYLTSGYVYESAAAAEAAFTGELDRFVYSRYGNPTVSMFEERLRLIEGAEACFATAS 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 86 GQAAQTLAIQGLAHTGDNIVSTSYLYGGTYNQFKISFKRFGIEARFVEGDNPEEFEKVFDERTKAVYLETIGNPKYNVPD 165
Cdd:PRK07810 94 GMSAVFTALGALLGAGDRLVAARSLFGSCFVVCNEILPRWGVETVFVDGEDLSQWEEALSVPTQAVFFETPSNPMQSLVD 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 166 FEKIVAIAHKHGIPVVVDNTFgAGGYFCQPIKYGADIVTHSATKwigghgttiggiIVDSgkfpwkdypekfpqfsqpae 245
Cdd:PRK07810 174 IAAVSELAHAAGAKVVLDNVF-ATPLLQRGLPLGADVVVYSGTK------------HIDG-------------------- 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 246 gyHGTIYNEA-YGNLAYIVHVRTELLRDLGPLMNPFASFLLLQGVETLSLRAERHGENALKLAKWLEQSPYVSWVSYPGL 324
Cdd:PRK07810 221 --QGRVLGGAiLGDREYIDGPVQKLMRHTGPALSAFNAWVLLKGLETLALRVRHSNASALRIAEFLEGHPAVRWVRYPFL 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 325 ASHSHHENAKKYLSNGfGGVLSFGVKDLPNADKETDPFKLSGAQVVDnlklASNlaNVGDAKTLVIAPYFTTHKQLNDKE 404
Cdd:PRK07810 299 PSHPQYDLAKRQMSGG-GTVVTFELDAPEDAAKKRAFEVLDKLRVID----ISN--NLGDAKSLITHPATTTHRAMGPEG 371
|
410 420 430
....*....|....*....|....*....|.
gi 6323333 405 KLASGVTKDLIRVSVGIEFIDDIIADFQQSF 435
Cdd:PRK07810 372 RAAIGLGDGVVRLSVGLEDTDDLIADLDRAL 402
|
|
| PRK07671 |
PRK07671 |
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase; |
7-436 |
4.38e-75 |
|
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase;
Pssm-ID: 181076 [Multi-domain] Cd Length: 377 Bit Score: 239.63 E-value: 4.38e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 7 TVQLHAGQenPGDNAHRSRAVPIYATTSYVFENS-KHgsqlfglevPGYVYSRFQNPTSNVLEERIAALEGGAAALAVSS 85
Cdd:PRK07671 5 TKLIHGGI--IGDPSTGAVSVPIYQVSTYKQEAVgKH---------QGYEYSRTGNPTRAALEELIAVLEGGHAGFAFGS 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 86 GQAAQTlAIQGLAHTGDNIVSTSYLYGGTYNQFKISFKRFGIEARFVEGDNPEEFEKVFDERTKAVYLETIGNPKYNVPD 165
Cdd:PRK07671 74 GMAAIT-AVMMLFSSGDHVILTDDVYGGTYRVMTKVLNRFGIEHTFVDTSNLEEVEEAIRPNTKAIYVETPTNPLLKITD 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 166 FEKIVAIAHKHGIPVVVDNTFgAGGYFCQPIKYGADIVTHSATKWIgghgttiggiivdsgkfpwkdypekfpqfsqpae 245
Cdd:PRK07671 153 IKKISTIAKEKGLLTIVDNTF-MTPYWQSPISLGADIVLHSATKYL---------------------------------- 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 246 GYHGTIyneaygnLAYIVHVRT-ELLRDL-------GPLMNPFASFLLLQGVETLSLRAERHGENALKLAKWLEQSPYVS 317
Cdd:PRK07671 198 GGHSDV-------VAGLVVVNSpELAEDLhfvqnstGGILGPQDSWLLLRGLKTLGIRMEEHETNSRAIAEFLNNHPAVN 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 318 WVSYPGLASHSHHENAKKYlSNGFGGVLSFGVKDLPNADKetdpfklsgaqVVDNLKLASNLANVGDAKTLVIAPYFTTH 397
Cdd:PRK07671 271 KVYYPGLPSHPNHELAKEQ-ANGFGGMISFDVGSEETANK-----------VLERLQYFTLAESLGAVESLISIPSQMTH 338
|
410 420 430
....*....|....*....|....*....|....*....
gi 6323333 398 KQLNDKEKLASGVTKDLIRVSVGIEFIDDIIADFQQSFE 436
Cdd:PRK07671 339 ASIPADRRKELGITDGLIRISVGIEDGEDLIEDLAQALA 377
|
|
| PRK08249 |
PRK08249 |
cystathionine gamma-synthase family protein; |
3-438 |
4.45e-74 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 236202 [Multi-domain] Cd Length: 398 Bit Score: 237.72 E-value: 4.45e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 3 SHFDTVQLHAGQENpgDNAHRSRAVPIYATTSYVFENSKHGSQLFGLEVPGYVYSRFQNPTSNVLEERIAALEGGAAALA 82
Cdd:PRK08249 7 AGVGTKAVWAGEKE--YLPYGATQVPVVLSVAYGYDDIDEWYDVALGKKPGHIYSRNTNPTVQAFEEKVRILEGAEAATA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 83 VSSGQAAQTLAIQGLAHTGDNIVSTSYLYGGTYNQFKISFKRFGIEARFVEGDNPEEFEKVFDERTKAVYLETIGNPKYN 162
Cdd:PRK08249 85 FSTGMAAISNTLYTFLKPGDRVVSIKDTYGGTNKIFTEFLPRMGVDVTLCETGDHEQIEAEIAKGCDLLYLETPTNPTLK 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 163 VPDFEKIVAIAHKHGIPVVVDNTFgAGGYFCQPIKYGADIVTHSATKWigghgttiggiivdsgkfpwkdypekfpqFSQ 242
Cdd:PRK08249 165 IVDIERLAAAAKKVGALVVVDNTF-ATPINQNPLALGADLVIHSATKF-----------------------------LSG 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 243 PAEGYHGTiyneAYGNLAYIVHVRTelLRDL-GPLMNPFASFLLLQGVETLSLRAERHGENALKLAKWLEQSPYVSWVSY 321
Cdd:PRK08249 215 HADALGGV----VCGSKELMEQVYH--YREInGATMDPMSAYLILRGMKTLKLRVRQQQESAMALAKYLQTHPKVEAVYY 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 322 PGLASHSHHENAKKYLSnGFGGVLSFGVKDLPNADKETDPfklsgaqvvdNLKLASNLANVGDAKTLVIAPYFTTHKQLN 401
Cdd:PRK08249 289 PGLETHPNHEIAKAQMR-GFGGILSFVLKGGMDTVKRLLP----------KLRYAHRAANLGAVETIYGPARTTSHVENT 357
|
410 420 430
....*....|....*....|....*....|....*..
gi 6323333 402 DKEKLASGVTKDLIRVSVGIEFIDDIIADFQQSFETV 438
Cdd:PRK08249 358 LEERAALGIPEGLVRISVGIEDTEDLIADLEQAFAHL 394
|
|
| PRK05939 |
PRK05939 |
cystathionine gamma-synthase family protein; |
28-438 |
3.42e-73 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 235650 [Multi-domain] Cd Length: 397 Bit Score: 235.35 E-value: 3.42e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 28 PIYATTSYVFENSKHGSQLFGLEVPGYVYSRFQNPTSNVLEERIAALEGGAAALAVSSGQAAQTLAIQGLAHTGDNIVST 107
Cdd:PRK05939 13 PIHTSVTYGYEDARDLIDVFQGKKPGFTYARQGTPTTAALEAKITKMEGGVGTVCFATGMAAIAAVFLTLLRAGDHLVSS 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 108 SYLYGGTyNQFKISFKRFGIEARFVEGDNPEEFEKVFDERTKAVYLETIGNPKYNVPDFEKIVAIAHKHGIPVVVDNTFG 187
Cdd:PRK05939 93 QFLFGNT-NSLFGTLRGLGVEVTMVDATDVQNVAAAIRPNTRMVFVETIANPGTQVADLAGIGALCRERGLLYVVDNTMT 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 188 AGGYFcQPIKYGADIVTHSATKWIGGHGTTIGGIIVDSGKFPWKDYPEKFPQF-SQPAEGYHgtiyneaygnlayIVHVR 266
Cdd:PRK05939 172 SPWLF-RPKDVGASLVINSLSKYIAGHGNALGGAVTDTGLFDWSAYPNIFPAYrKGDPQQWG-------------LTQIR 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 267 TELLRDLGPLMNPFASFLLLQGVETLSLRAERHGENALKLAKWLEQSPYVSWVSYPGLASHSHHENAKKYLSnGFGGVLS 346
Cdd:PRK05939 238 KKGLRDMGATLSSEAAHRIAIGAETLALRVDRSCSNALALAQFLEAHPKVARVYYPGLASHPQHARATELFR-HYGGLLS 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 347 FGVKDlpnadkETDPFklsgaQVVDNLKLASNLANVGDAKTLVIAPYFTTHKQLNDKEKLASGVTKDLIRVSVGIEFIDD 426
Cdd:PRK05939 317 FELAD------GIDCF-----DFLNRLKLVIKATHLGDTRTLVIPVAPTIYYEMGAERRASMGIADSLIRVSVGIEDEAD 385
|
410
....*....|..
gi 6323333 427 IIADFQQSFETV 438
Cdd:PRK05939 386 LIADFEQALDAT 397
|
|
| PRK07811 |
PRK07811 |
cystathionine gamma-synthase; Provisional |
4-436 |
1.86e-69 |
|
cystathionine gamma-synthase; Provisional
Pssm-ID: 236104 [Multi-domain] Cd Length: 388 Bit Score: 225.29 E-value: 1.86e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 4 HFDTVQLHAGQEnPgDNAHRSRAVPIYATTSYVfENSKHGsqLFGlevpGYVYSRFQNPTSNVLEERIAALEGGAAALAV 83
Cdd:PRK07811 12 GFATRAIHAGYE-P-DPATGAVNPPIYASSTFA-QDGVGG--LRG----GYEYARTGNPTRTALEEQLAALEGGAYGRAF 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 84 SSGQAAQTLAIQGLAHTGDNIVSTSYLYGGTYNQFKISFKRFGIEARFVEGDNPEEFEKVFDERTKAVYLETIGNPKYNV 163
Cdd:PRK07811 83 SSGMAATDCLLRAVLRPGDHIVIPNDAYGGTFRLIDKVFTRWGVEYTPVDLSDLDAVRAAITPRTKLIWVETPTNPLLSI 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 164 PDFEKIVAIAHKHGIPVVVDNTFgAGGYFCQPIKYGADIVTHSATKWIgghgttiggiivdsgkfpwkdypekfpqfsqp 243
Cdd:PRK07811 163 TDIAALAELAHDAGAKVVVDNTF-ASPYLQQPLALGADVVVHSTTKYI-------------------------------- 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 244 aeGYHGTIYNEAygnlayIVHVRTELLRDLGPLMN-------PFASFLLLQGVETLSLRAERHGENALKLAKWLEQSPYV 316
Cdd:PRK07811 210 --GGHSDVVGGA------LVTNDEELDEAFAFLQNgagavpgPFDAYLTLRGLKTLAVRMDRHSENAEAVAEFLAGHPEV 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 317 SWVSYPGLASHSHHENAKKYLSnGFGGVLSFGVKDLPNADKEtdpfklsgaqVVDNLK---LASNLANVgdaKTLVIAPY 393
Cdd:PRK07811 282 STVLYPGLPSHPGHEVAARQMR-GFGGMVSVRLAGGEEAARD----------FCARTKvftLAESLGGV---ESLIEHPS 347
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 6323333 394 FTTHKQlndkeklASG----VTKDLIRVSVGIEFIDDIIADFQQSFE 436
Cdd:PRK07811 348 AMTHAS-------TAGsqleVPDDLVRLSVGIEDVADLLADLEQALG 387
|
|
| PRK08247 |
PRK08247 |
methionine biosynthesis PLP-dependent protein; |
1-438 |
1.81e-66 |
|
methionine biosynthesis PLP-dependent protein;
Pssm-ID: 181320 [Multi-domain] Cd Length: 366 Bit Score: 216.88 E-value: 1.81e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 1 MPSHFDTVQLHAGqeNPGDNAHRSRAVPIYATTSYvfensKHGsqlfGL-EVPGYVYSRFQNPTSNVLEERIAALEGGAA 79
Cdd:PRK08247 1 QMSTIETKLAQIG--NRSDERTGTVNPPVYFSTAY-----RHE----GIgESTGFDYSRTGNPTRGVLEQAIADLEGGDQ 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 80 ALAVSSGQAA-QTlaIQGLAHTGDNIVSTSYLYGGTYNQFKISFKRFGIEARFVEGDNPEEFEKVFDERTKAVYLETIGN 158
Cdd:PRK08247 70 GFACSSGMAAiQL--VMSLFRSGDELIVSSDLYGGTYRLFEEHWKKWNVRFVYVNTASLKAIEQAITPNTKAIFIETPTN 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 159 PKYNVPDFEKIVAIAHKHGIPVVVDNTFgAGGYFCQPIKYGADIVTHSATKWIGGHGTTIGGIIVDSGKfpwkdypekfp 238
Cdd:PRK08247 148 PLMQETDIAAIAKIAKKHGLLLIVDNTF-YTPVLQRPLEEGADIVIHSATKYLGGHNDVLAGLVVAKGQ----------- 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 239 QFSQPAEGYHGTIyneaygnlayivhvrtellrdlGPLMNPFASFLLLQGVETLSLRAERHGENALKLAKWLEQSPYVSW 318
Cdd:PRK08247 216 ELCERLAYYQNAA----------------------GAVLSPFDSWLLIRGMKTLALRMRQHEENAKAIAAFLNEQPGVTD 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 319 VSYPGLashshhenakkylsngfGGVLSFGVKDlpnaDKETDPFklsgaqvVDNLKLASNLANVGDAKTLVIAPYFTTHK 398
Cdd:PRK08247 274 VLYPGR-----------------GGMLSFRLQD----EEWVNPF-------LKSLKLITFAESLGGVESFITYPATQTHA 325
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 6323333 399 QLNDKEKLASGVTKDLIRVSVGIEFIDDIIADFQQSFETV 438
Cdd:PRK08247 326 DIPEEIRIANGVCNRLLRFSVGIENVEDLIADLKQAFKQV 365
|
|
| PRK06176 |
PRK06176 |
cystathionine gamma-synthase; |
4-436 |
1.09e-64 |
|
cystathionine gamma-synthase;
Pssm-ID: 180443 [Multi-domain] Cd Length: 380 Bit Score: 212.84 E-value: 1.09e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 4 HFDTVQLHAGQENpgDNAHRSRAVPIYATTSYvfenskhgsQLFGLEVP-GYVYSRFQNPTSNVLEERIAALEGGAAALA 82
Cdd:PRK06176 2 RMQTKLIHGGISE--DTTTGAVSVPIYQTSTY---------RQDAIGRPkGYEYSRSGNPTRFALEELIADLEGGVKGFA 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 83 VSSGQAAqTLAIQGLAHTGDNIVSTSYLYGGTYNQFKISFKRFGIEARFVEGDNPEEFEKVFDERTKAVYLETIGNPKYN 162
Cdd:PRK06176 71 FASGLAG-IHAVFSLFQSGDHVLLGDDVYGGTFRLFDKVLVKNGLSCTIIDTSDLSQIKKAIKPNTKALYLETPSNPLLK 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 163 VPDFEKIVAIAHKHGIPVVVDNTFgAGGYFCQPIKYGADIVTHSATKWigghgttiggiivdsgkfpwkdypekFPQFSQ 242
Cdd:PRK06176 150 ITDLAQCASVAKDHGLLTIVDNTF-ATPYYQNPLLLGADIVVHSGTKY--------------------------LGGHSD 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 243 PAEGYHGTIYNEAYGNLAYivhvrteLLRDLGPLMNPFASFLLLQGVETLSLRAERHGENALKLAKWLEQSPYVSWVSYP 322
Cdd:PRK06176 203 VVAGLVTTNNEALAQEIAF-------FQNAIGGVLGPQDSWLLQRGIKTLGLRMEAHQKNALCVAEFLEKHPKVEKVYYP 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 323 GLASHSHHENAKKYLSnGFGGVLSFGVKDlpnaDKETDPFklsgaqvVDNLKLASNLANVGDAKTLVIAPYFTTHKQLND 402
Cdd:PRK06176 276 GLPTHPNHELAKKQMR-GFSGMLSFTLKN----DSEAVAF-------VESLKLFILGESLGGVESLVGIPAFMTHACIPK 343
|
410 420 430
....*....|....*....|....*....|....
gi 6323333 403 KEKLASGVTKDLIRVSVGIEFIDDIIADFQQSFE 436
Cdd:PRK06176 344 EQREAAGIRDGLVRLSVGIEHEQDLLEDLEQAFA 377
|
|
| PRK07504 |
PRK07504 |
O-succinylhomoserine sulfhydrylase; Reviewed |
29-440 |
1.14e-62 |
|
O-succinylhomoserine sulfhydrylase; Reviewed
Pssm-ID: 168979 [Multi-domain] Cd Length: 398 Bit Score: 208.07 E-value: 1.14e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 29 IYATTSYVFENSKHGSQLFGLEVPGYVYSRFQNPTSNVLEERIAALEGGAAALAVSSGQAAQTLAIQGLAHTGDNIVSTS 108
Cdd:PRK07504 32 LFLTQGFVYDTAEAAEARFKGEDPGFIYSRYSNPTVDMFEKRMCALEGAEDARATASGMAAVTAAILCQVKAGDHVVAAR 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 109 YLYGGTYNQFKISFKRFGIEARFVEGDNPEEFEKVFDERTKAVYLETIGNPKYNVPDFEKIVAIAHKHGIPVVVDNTFgA 188
Cdd:PRK07504 112 ALFGSCRYVVETLLPRYGIESTLVDGLDLDNWEKAVRPNTKVFFLESPTNPTLEVIDIAAVAKIANQAGAKLVVDNVF-A 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 189 GGYFCQPIKYGADIVTHSATKwigghgttiggiIVDsgkfpwkdypekfpqfsqpaeGYHGTIYNEAYGNLAYIVHVRTE 268
Cdd:PRK07504 191 TPLFQKPLELGAHIVVYSATK------------HID---------------------GQGRCLGGVVLSDKAWIEEHLQD 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 269 LLRDLGPLMNPFASFLLLQGVETLSLRAERHGENALKLAKWLEQSPYVSWVSYPGLASHSHHENAKKYLSNGfGGVLSFG 348
Cdd:PRK07504 238 YFRHTGPSLSPFNAWTLLKGLETLPVRVRQQTESAAAIADFLAGHPKVARVIYPGRADHPQADIIAKQMTGG-STLVAFE 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 349 VKdlpnADKETdPFKLSGAqvvdnLKLASNLANVGDAKTLVIAPYFTTHKQLNDKEKLASGVTKDLIRVSVGIEFIDDII 428
Cdd:PRK07504 317 LK----GGKEA-AFRFLNA-----LKIVRISNNLGDAKSLITHPATTTHKNLSPEARAELGISEGFLRLSAGLEDTDDLI 386
|
410
....*....|..
gi 6323333 429 ADFQQSFETVFA 440
Cdd:PRK07504 387 EDLAAALKKVRA 398
|
|
| PRK06434 |
PRK06434 |
cystathionine gamma-lyase; Validated |
28-435 |
8.65e-62 |
|
cystathionine gamma-lyase; Validated
Pssm-ID: 102374 [Multi-domain] Cd Length: 384 Bit Score: 205.14 E-value: 8.65e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 28 PIYATTSYVFENSKHGSQLFGLEVPGYVYSRFQNPTSNVLEERIAALEGGAAALAVSSGQAAQTLAIQGLAHTGDNIVST 107
Cdd:PRK06434 30 PIFETSTFVYPNSEKEAYMDSTRGMPYIYTRWGNPTVQAFEEKYAVLENAEHALSFSSGMGAITSAILSLIKKGKRILSI 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 108 SYLYGGTYNQFKISFKRFGIEARFVEGD--NPEEFE-KVFDertkAVYLETIGNPKYNVPDFEKIVAIAHKHgiPVVVDN 184
Cdd:PRK06434 110 SDLYGQTFYFFNKVLKTLGIHVDYIDTDrlNSLDFDpSNYD----LIYAESITNPTLKVPDIKNVSSFCHEN--DVIVDA 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 185 TFgAGGYFCQPIKYGADIVTHSATKWIgghgttiggiivdSGKfpwkdypekfpqfSQPAEGYHGTIYNEAYGNLayivh 264
Cdd:PRK06434 184 TF-ASPYNQNPLDLGADVVIHSATKYI-------------SGH-------------SDVVMGVAGTNNKSIFNNL----- 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 265 vrTELLRDLGPLMNPFASFLLLQGVETLSLRAERHGENALKLAKWLEQSPYVSWVSYPGLashshhENAKKYLSnGFGGV 344
Cdd:PRK06434 232 --VERRKTLGSNPDPIQAYLALRGLKTLGLRMEKHNKNGMELARFLRDSKKISNVYYPDT------EIGKKVLR-GFGGM 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 345 LSFGVKDLPNADKetdpfklsgaqVVDNLKLASNLANVGDAKTLVIAPYFTTHKQLNDKEKLASGVTKDLIRVSVGIEFI 424
Cdd:PRK06434 303 LSFELRSMEDVHK-----------FIRNLEIPMVAASLGGVESLITLPVETSHSSLSPEERERLGISDNLVRFSIGIEDI 371
|
410
....*....|.
gi 6323333 425 DDIIADFQQSF 435
Cdd:PRK06434 372 DDLIKDIENAL 382
|
|
| PRK06460 |
PRK06460 |
hypothetical protein; Provisional |
28-439 |
2.44e-61 |
|
hypothetical protein; Provisional
Pssm-ID: 235807 [Multi-domain] Cd Length: 376 Bit Score: 203.91 E-value: 2.44e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 28 PIYATTSYVF-ENSKhgsqlfglevpgYVYSRFQNPTSNVLEERIAALEGGAAALAVSSGQAAQTLAIQGLAHTGDNIVS 106
Cdd:PRK06460 22 PIYQTTAYHYpEGEK------------YRYSREANPTVLELTKKIVELENAEMGVAFSSGMGAISTTALALLKPGNSVLV 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 107 TSYLYGGTYNQFKISFKRFGIEARFVEGDNPEEFEKVFDERTKAVYLETIGNPKYNVPDFEKIVAIAHKHGIPVVVDNTF 186
Cdd:PRK06460 90 HRDMFGRSYRFFTDYLKNWGVNVDASNPGSDNIIEKAKSKRYDVVFVENITNPLLRVVDITELSKVCKENGSILIVDATF 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 187 gAGGYFCQPIKYGADIVTHSATKWIGghgttiggiivdsgkfpwkdypekfpqfsqpaeGYHGTIYNEAYGNLAYIVHVr 266
Cdd:PRK06460 170 -STPINQKPLELGADIVVHSASKFLA---------------------------------GHNDVIAGLAAGYGKLLNVI- 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 267 TELLRDLGPLMNPFASFLLLQGVETLSLRAERHGENALKLAKWLEQSPYVSWVSYPGLASHSHHENAKKYLsNGFGGVLS 346
Cdd:PRK06460 215 DQMRRTLGTSLDPHAAYLTLRGIKTLKIRMDVINRNAEQIAEFLEGHPKVVKVYYPGLKSHVDYEIARRVL-KGFGGVLS 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 347 FGVKDLPNadketdpfklSGAQVVDNLKLASNLANVGDAKTLVIAPYFTTHKQLNDKEKLASGVTKDLIRVSVGIEFIDD 426
Cdd:PRK06460 294 FEVNGGQE----------SALKVMKSLKLIIPAQTLGGVNSVISHPATMSHRTLSLEERKIVGITDSLLRLSVGIEDVND 363
|
410
....*....|...
gi 6323333 427 IIADFQQSFETVF 439
Cdd:PRK06460 364 LIEDLDRALSTLY 376
|
|
| cysta_beta_ly_E |
TIGR01329 |
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase ... |
15-437 |
7.43e-61 |
|
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys.
Pssm-ID: 273557 [Multi-domain] Cd Length: 378 Bit Score: 202.75 E-value: 7.43e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 15 ENPGDNAHRSrAVPIYATTSYVFENSKHGSQlfglevpgYVYSRFQNPTSNVLEERIAALEGGAAALAVSSGQAAQTlAI 94
Cdd:TIGR01329 9 DNKNDPYDAS-SMPIYQTATFKQPLAIENGP--------YDYTRSGNPTRTALESLLAKLDKADRAFAFSSGMAALD-VI 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 95 QGLAHTGDNIVSTSYLYGGTY---NQFKisfKRFGIEARFVEGDNPEEFEKVFDERTKAVYLETIGNPKYNVPDFEKIVA 171
Cdd:TIGR01329 79 TRLLNNGDEIIAGDDLYGGTDrllTQVV---PRSGVVVVHVDTTDLDKVKAALGPKTKLVLLESPTNPLQKIVDIRKISE 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 172 IAHKHGIPVVVDNTFgAGGYFCQPIKYGADIVTHSATKWIGghgttiggiivdsgkfpwkdypekfpqfsqpaeGYHGTi 251
Cdd:TIGR01329 156 MAHAQNALVVVDNTM-MSPLLCNPLELGADIVYHSATKFLA---------------------------------GHSDV- 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 252 yneaygnLAYIVHVRTE--------LLRDLGPLMNPFASFLLLQGVETLSLRAERHGENALKLAKWLEQSPYVSWVSYPG 323
Cdd:TIGR01329 201 -------MAGVLAVKGEeiakkvyfLQNSTGSGLAPFDCWLLLRGIKTLAIRIEKQQENARAIAMFLSTHPRVKKVRYAG 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 324 LASHSHHEnAKKYLSNGFGGVLSFgvkdlpnadkETDPFKLSGAqVVDNLKLASNLANVGDAKTLVIAPYFTTHKQLNDK 403
Cdd:TIGR01329 274 LPSHPGFH-LHFSQAKGAGSVLSF----------ETGSVALSKR-LVEATKLFSITVSFGSVNSLISMPCFMSHASIPAE 341
|
410 420 430
....*....|....*....|....*....|....
gi 6323333 404 EKLASGVTKDLIRVSVGIEFIDDIIADFQQSFET 437
Cdd:TIGR01329 342 VREERGLPEDLVRLSVGIEDVDDLISDLDIAFVT 375
|
|
| PRK08574 |
PRK08574 |
cystathionine gamma-synthase family protein; |
28-438 |
1.78e-57 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 236298 [Multi-domain] Cd Length: 385 Bit Score: 193.74 E-value: 1.78e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 28 PIYATTSYVFENSKHGSQLfGLEVPgyvYSRFQNPTSNVLEERIAALEGGAAALAVSSGQAAQTLAIQGLAHTGDNIVST 107
Cdd:PRK08574 23 PIYLTALFRQEGEAYPSDR-GFDLK---YSREENPTLRPLEEALAKLEGGVDALAFNSGMAAISTLFFSLLKAGDRVVLP 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 108 SYLYGGTYnQFKISFKRFGIEARFVEGDNPEEFEKVFDERTKAVYLETIGNPKYNVPDFEKIVAIAHKHGIPVVVDNTFg 187
Cdd:PRK08574 99 MEAYGTTL-RLLKSLEKFGVKVVLAYPSTEDIIEAIKEGRTKLVFIETMTNPTLKVIDVPEVAKAAKELGAILVVDNTF- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 188 AGGYFCQPIKYGADIVTHSATKWIgghgttiggiivdSGkfpwkdypekfpqfsqpaegyhgtiYNEAYGNLAyIVHVRT 267
Cdd:PRK08574 177 ATPLLYRPLRHGADFVVHSLTKYI-------------AG-------------------------HNDVVGGVA-VAWSGE 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 268 ELL------RDLGPLMNPFASFLLLQGVETLSLRAERHGENALKLAKWLEQSPYVSWVSYPGLASHSHHENAKKYLSNG- 340
Cdd:PRK08574 218 FLEelwewrRRLGTIMQPFEAYLVLRGLKTLEVRFERQCRNAMAIAEFLSEHPKVAEVYYPGLPSDPYHGVAKRLFGKDl 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 341 FGGVLSFGVKDLPNADKetdpfklsgaQVVDNLKLASNLANVGDAKTLVIAPYFTTHKQLNDKEKLASGVTKDLIRVSVG 420
Cdd:PRK08574 298 YGGVVSFRVKGGRDAVL----------KFLRSLKLIKPSPSLGGVESLATYPVKSAASPIPEEDRKALGITEDLVRLSVG 367
|
410
....*....|....*...
gi 6323333 421 IEFIDDIIADFQQSFETV 438
Cdd:PRK08574 368 LEDVEDLIEDLDQALGSI 385
|
|
| PRK08064 |
PRK08064 |
cystathionine beta-lyase MetC; |
5-438 |
1.13e-54 |
|
cystathionine beta-lyase MetC;
Pssm-ID: 236146 [Multi-domain] Cd Length: 390 Bit Score: 186.52 E-value: 1.13e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 5 FDTVQLHAgqENPGDNAHRSRAVPIY-ATTSYVFENSKHGSqlfglevpgYVYSRFQNPTSNVLEERIAALEGGAAALAV 83
Cdd:PRK08064 7 IDTLLLHN--QYKHDKQTGAVNVPIYhASTFHQFDFDTFGK---------YDYSRSGNPTREALEDIIAELEGGTKGFAF 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 84 SSGQAAQTLAIQGLAHtGDNIVSTSYLYGGTYNQFKISFKRFGIEARFVEGDNPEEFEKVFDERTKAVYLETIGNPKYNV 163
Cdd:PRK08064 76 ASGMAAISTAFLLLSK-GDHVLISEDVYGGTYRMITEVLSRFGIEHTFVDMTNLEEVAQNIKPNTKLFYVETPSNPLLKV 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 164 PDFEKIVAIAHKHGIPVVVDNTFgAGGYFCQPIKYGADIVTHSATKWigghgtTIGGIIVDSGKFPWKDypekfpqfsqp 243
Cdd:PRK08064 155 TDIRGVVKLAKAIGCLTFVDNTF-LTPLLQKPLDLGADVVLHSATKF------LAGHSDVLAGLAVVKD----------- 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 244 aegyhgtiyneaygnlayivhvrTELLRDLGPLMNPFA-------SFLLLQGVETLSLRAERHGENALKLAKWLEQSPYV 316
Cdd:PRK08064 217 -----------------------EELAQKLYFLQNSFGavlgvqdCWLVLRGLKTLHVRLEHSSETANKIALYLQEHPKV 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 317 SWVSYPGLASHSHHEnAKKYLSNGFGGVLSFgvkDLPNADketdpfklSGAQVVDNLKLASNLANVGDAKTLVIAPYFTT 396
Cdd:PRK08064 274 QNVYYPGLQTHLGFD-IQQSQATSAGAVLSF---TLQSEE--------AVRQFVSHVKLPVFAVSLGAVESILSYPAKMS 341
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 6323333 397 HKQLNDKEKLASGVTKDLIRVSVGIEFIDDIIADFQQSFETV 438
Cdd:PRK08064 342 HAAMPKEERDERGITDGLLRLSVGLENVDDLIADFEQALSYV 383
|
|
| PRK07269 |
PRK07269 |
cystathionine gamma-synthase; Reviewed |
4-436 |
1.83e-51 |
|
cystathionine gamma-synthase; Reviewed
Pssm-ID: 235983 Cd Length: 364 Bit Score: 177.32 E-value: 1.83e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 4 HFDTVQLHAGQENpgDNAHRSRAVPIYATTSYvfensKHGSqlFGlEVPGYVYSRFQNPTSNVLEERIAALEGGAAALAV 83
Cdd:PRK07269 6 HINTILAQAGIKS--DEATGALVTPLHFSTTY-----QHPE--FG-QSTGFDYTRTKNPTRAKLEETLAAIESADYALAT 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 84 SSGQAAQTLAIQGLAhTGDNIVSTSYLYGGTYNQFKISFK--RFgieaRFVEGDNPEEFEKVFDERTKAVYLETIGNPKY 161
Cdd:PRK07269 76 SSGMSAIVLAFSVFP-VGSKVVAVRDLYGGSFRWFNQQEKegRF----HFTYANTEEELIAAIEEDTDIVYIETPTNPLM 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 162 NVPDFEKIVAIAHKHGIPVVVDNTFGAGGYfCQPIKYGADIVTHSATKWIGGHGTTIGGIIVDSGkfpwkdypekfpqfs 241
Cdd:PRK07269 151 VEFDIEKVAKLAHAKGAKVIVDNTFYSPIY-QRPIELGADIVLHSATKYLSGHNDVLAGVVVTND--------------- 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 242 qpAEGYHGTIYNeaygnlayivhvrtelLRDLGPLMNPFASFLLLQGVETLSLRAERHGENALKLAKWLEQSPYVSWVSY 321
Cdd:PRK07269 215 --LELYEKLFYN----------------LNTTGAVLSPFDSYLLMRGLKTLSLRMERSTANAQEVVAFLKKSPAVKEVLY 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 322 PGLashshhenakkylsngfGGVLSFGVkdlpnADKETDPfklsgaQVVDNLKLASNLANVGDAKTLVIAPYFTTHKQLN 401
Cdd:PRK07269 277 TGK-----------------GGMISFKV-----ADETRIP------HILNSLKVFTFAESLGGVESLITYPTTQTHADIP 328
|
410 420 430
....*....|....*....|....*....|....*
gi 6323333 402 DKEKLASGVTKDLIRVSVGIEFIDDIIADFQQSFE 436
Cdd:PRK07269 329 AEVRHSYGLTDDLLRLSIGIEDARDLIADLKQALE 363
|
|
| PLN02509 |
PLN02509 |
cystathionine beta-lyase |
26-437 |
3.93e-51 |
|
cystathionine beta-lyase
Pssm-ID: 178125 [Multi-domain] Cd Length: 464 Bit Score: 179.45 E-value: 3.93e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 26 AVPIYATTSYvfenskhgSQLFGLEVPGYVYSRFQNPTSNVLEERIAALEGGAAALAVSSGQAAQTlAIQGLAHTGDNIV 105
Cdd:PLN02509 105 STPLYQTATF--------KQPSAIENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALS-AVTHLIKNGEEIV 175
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 106 STSYLYGGTYNQFKISFKRFGIEARFVEGDNPEEFEKVFDERTKAVYLETIGNPKYNVPDFEKIVAIAHKHGIPVVVDNT 185
Cdd:PLN02509 176 AGDDVYGGSDRLLSQVVPRSGVVVKRVNTTNLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKIAEMAHAQGALVLVDNS 255
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 186 FgAGGYFCQPIKYGADIVTHSATKWIGGHGTTIGGIIVDSGKFPWKDYpekfpQFSQPAEGyhgtiyneayGNLAyivhv 265
Cdd:PLN02509 256 I-MSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEV-----YFLQNSEG----------SGLA----- 314
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 266 rtellrdlgplmnPFASFLLLQGVETLSLRAERHGENALKLAKWLEQSPYVSWVSYPGLASHS----HHENAKkylsnGF 341
Cdd:PLN02509 315 -------------PFDCWLCLRGIKTMALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPghhlHFSQAK-----GA 376
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 342 GGVLSFgvkdlpnadkETDPFKLSgAQVVDNLKLASNLANVGDAKTLVIAPYFTTHKQLNDKEKLASGVTKDLIRVSVGI 421
Cdd:PLN02509 377 GSVFSF----------ITGSVALS-KHLVETTKYFSIAVSFGSVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGI 445
|
410
....*....|....*.
gi 6323333 422 EFIDDIIADFQQSFET 437
Cdd:PLN02509 446 EDVDDLISDLDIAFRT 461
|
|
| PRK07049 |
PRK07049 |
cystathionine gamma-synthase family protein; |
28-438 |
7.14e-51 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 180809 [Multi-domain] Cd Length: 427 Bit Score: 177.56 E-value: 7.14e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 28 PIYATTSYVFENSKHGSQLFGL-----EVP-----GYVYSRFQNPTSNVLEERIAALEGGAAALAVSSGQAAQTLAIQGL 97
Cdd:PRK07049 39 PVFLTSTFVFRSAEDGRDFFDYvsgrkEPPagegaGLVYSRFNHPNSEIVEDRLAVYEGAESAALFSSGMSAIATTLLAF 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 98 AHTGDNIVSTSYLYGGTYNQFKISFKRFGIEAR-FVEGDNPEEFEKVFDE-----RTKAVYLETIGNPKYNVPDFEKIVA 171
Cdd:PRK07049 119 VRPGDVILHSQPLYGGTETLLAKTFRNFGVGAVgFADGLSEAAIGAAAEAaaakgRVSLILIETPANPTNSLVDVAAVRR 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 172 IA------HKHGIPVVVDNTFgAGGYFCQPIKYGADIVTHSATKWigghgttiggiivdsgkfpwkdypekfpqfsqpAE 245
Cdd:PRK07049 199 VAdaiearQGHRPIIACDNTL-LGPVFQKPLEHGADLSVYSLTKY---------------------------------VG 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 246 GYHGTIYNEAYGNLAYIVHVRteLLRD-LGPLMNPFASFLLLQGVETLSLRAERHGENALKLAKWLEQSPYVSWVSYPG- 323
Cdd:PRK07049 245 GHSDLVAGAVLGRKALIRQVR--ALRSaIGTQLDPHSCWMLGRSLETLVLRMERANRNARAVAEFLRDHPKVEKLHYLPf 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 324 LASHSHHENAKKYLSNGFGGVLSFgvkDLPNADKETDPFkLSGAQVvdnLKLASNLanvGDAKTLVIAPYFTTHKQLNDK 403
Cdd:PRK07049 323 LDPDSAYGAVYKRQCTGAGSTFSF---DIKGGQAAAFRF-LNALQI---FKLAVSL---GGTESLASHPASMTHSGVPAD 392
|
410 420 430
....*....|....*....|....*....|....*
gi 6323333 404 EKLASGVTKDLIRVSVGIEFIDDIIADFQQSFETV 438
Cdd:PRK07049 393 VRERIGVLESTIRLSIGIEHPDDLIADLAQALDAA 427
|
|
| PRK08861 |
PRK08861 |
O-succinylhomoserine (thiol)-lyase; |
7-436 |
7.24e-51 |
|
O-succinylhomoserine (thiol)-lyase;
Pssm-ID: 181567 [Multi-domain] Cd Length: 388 Bit Score: 176.62 E-value: 7.24e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 7 TVQLHAGQENpgDNAHRSRAVPIYATTSYVFENskhgsqlFGlEVPGYVYSRFQNPTSNVLEERIAALEGGAAALAVSSG 86
Cdd:PRK08861 8 TIAVRTGIES--DSQYHAVVPPIYLSTNYGFPA-------FG-EVPKYDYTRSGNPNRGLLEQTLSELESGKGAVVTNCG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 87 QAAQTLAIQGLAHTGDNIVSTSYLYGGTYNQFKISFKRFGIEARFVEGDNPEEFEKVFDERTKAVYLETIGNPKYNVPDF 166
Cdd:PRK08861 78 TSALNLWVSALLGPDDLIVAPHDCYGGTYRLFNTRANKGDFKVQFVDQSDAAALDAALAKKPKLILLETPSNPLVRVVDI 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 167 EKIVAIAHKHGIPVVVDNTFgAGGYFCQPIKYGADIVTHSATKWigghgtTIGGIIVDSGKFPWKDypekfpqfSQPAEg 246
Cdd:PRK08861 158 AELCQKAKAVGALVAVDNTF-LTPVLQKPLELGADFVIHSTTKY------INGHSDVIGGVLITKT--------KEHAE- 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 247 yhgtiyneaygNLAYIVHVrtellrdLGPLMNPFASFLLLQGVETLSLRAERHGENALKLAKWLEQSPYVSWVSYPGLAS 326
Cdd:PRK08861 222 -----------ELAWWGNC-------IGATGTPFDSYMTLRGIRTLGARMRVHEESAQQILAYLQTQSLVGTIYHPSLPE 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 327 HSHHENAKKYLSnGFGGVLSFgvkDLPNADKETDPFklsgaqvVDNLKLASNLANVGDAKTLVIAPYFTTHKQLNDKEKL 406
Cdd:PRK08861 284 HPGHEIAKKQQS-GFGSMLSF---EFAGSFEQLKVF-------VKALALFSLAESLGGVESLICHPASMTHRAMGEEALA 352
|
410 420 430
....*....|....*....|....*....|
gi 6323333 407 ASGVTKDLIRVSVGIEFIDDIIADFQQSFE 436
Cdd:PRK08861 353 EAGVSQQLLRLSVGLEDAQDLIADLDQAFA 382
|
|
| PRK08776 |
PRK08776 |
O-succinylhomoserine (thiol)-lyase; |
2-436 |
2.27e-47 |
|
O-succinylhomoserine (thiol)-lyase;
Pssm-ID: 181554 [Multi-domain] Cd Length: 405 Bit Score: 167.86 E-value: 2.27e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 2 PSHFDTVQLHAGQENpgDNAHRSRAVPIYATTSYVFENSKHGSQlfglevpgYVYSRFQNPTSNVLEERIAALEGGAAAL 81
Cdd:PRK08776 10 PCSAATAAVRAGIDR--DTAYGAVTPPIVLSSNFSFDGFGNKRQ--------YDYTRSGNPTRDLLGEALAELEGGAGGV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 82 AVSSGQAAQTLAIQGLAHTGDNIVSTSYLYGGTYNQFKISFKRFGIEARFVEGDNPEEFEKVFDERTKAVYLETIGNPKY 161
Cdd:PRK08776 80 ITATGMGAINLVLNALLQPGDTLVVPHDAYGGSWRLFNALAKKGHFALITADLTDPRSLADALAQSPKLVLIETPSNPLL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 162 NVPDFEKIVAIAHKHGIPVVVDNTFGAGGyFCQPIKYGADIVTHSATKWigghgtTIGGIIVDSGKFPWKDypekfpqfs 241
Cdd:PRK08776 160 RITDLRFVIEAAHKVGALTVVDNTFLSPA-LQKPLEFGADLVLHSTTKY------INGHSDVVGGAVVARD--------- 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 242 qpAEGYHGTIYneaYGNLayivhvrtellrdLGPLMNPFASFLLLQGVETLSLRAERHGENALKLAKWLEQSPYVSWVSY 321
Cdd:PRK08776 224 --AELHQQLVW---WANA-------------LGLTGSPFDAFLTLRGLRTLDARLRVHQENADAIAALLDGHAAVNQVYY 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 322 PGLASHSHHENAKKYlSNGFGGVLSFgvkDLPNADKETDPFklsgaqvVDNLKLASNLANVGDAKTLVIAPYFTTHKQLN 401
Cdd:PRK08776 286 PGLASHPGHALAARQ-QKGFGAMLSF---ELEGGEAAVRAF-------VDGLRYFTLAESLGGVESLIAHPASMTHAAMT 354
|
410 420 430
....*....|....*....|....*....|....*
gi 6323333 402 DKEKLASGVTKDLIRVSVGIEFIDDIIADFQQSFE 436
Cdd:PRK08776 355 AEARAAAGISDGLLRLSVGIESAEDLLIDLRAGLA 389
|
|
| PRK05968 |
PRK05968 |
hypothetical protein; Provisional |
19-436 |
8.23e-44 |
|
hypothetical protein; Provisional
Pssm-ID: 168320 [Multi-domain] Cd Length: 389 Bit Score: 157.94 E-value: 8.23e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 19 DNAHRSRAV--PIYATTSYVFENSKHGSQLFGLEVPGYVYSRFQNPTSNVLEERIAALEGGAAALAVSSGQAAQTLAIQG 96
Cdd:PRK05968 18 DEGNAFDAVvpPIFQTSLFTFDSYDEMEDVYAGEKVRPIYSRGDNPTVRAFEEMLAKLEGAEDARGFASGMAAISSTVLS 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 97 LAHTGDNIVSTSYLYGGTYNQFKISFKRFGIEARFVEGDNPEEFEKVFDErTKAVYLETIGNPKYNVPDFEKIVAIAHKH 176
Cdd:PRK05968 98 FVEPGDRIVAVRHVYPDAFRLFETILKRMGVEVDYVDGRDEEAVAKALPG-AKLLYLESPTSWVFELQDVAALAALAKRH 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 177 GIPVVVDNTFgAGGYFCQPIKYGADIVTHSATKWIGghgttiggiivdsgkfpwkdypekfpqfsqpaeGYHGTIYNEAY 256
Cdd:PRK05968 177 GVVTMIDNSW-ASPVFQRPITLGVDLVIHSASKYLG---------------------------------GHSDTVAGVVA 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 257 GNLAYIVHVRTELLRDLGPLMNPFASFLLLQGVETLSLRAERHGENALKLAKWLEQSPYVSWVSYPGLASHshhenAKKY 336
Cdd:PRK05968 223 GSKEHIARINAEAYPYLGAKLSPFEAWLLLRGLRTLPLRMKAHEASALEIARRLKAHPVVERVCHPALANH-----PPAG 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 337 LSnGFGGVLSFGVKDlpNADKETdpfklsgaqVVDNLKLASNLANVGDAKTLVIaPYFTTHKQLNDKEKLAS-GVTKDLI 415
Cdd:PRK05968 298 LS-GTSGLFSFIFRE--GIDVRA---------FADALKLFRLGVSWGGHESLVV-PAEVVLQQKAQPNSAARfGVSPRSV 364
|
410 420
....*....|....*....|.
gi 6323333 416 RVSVGIEFIDDIIADFQQSFE 436
Cdd:PRK05968 365 RLHVGLEGTEALWADLEQALA 385
|
|
| PRK08045 |
PRK08045 |
cystathionine gamma-synthase; Provisional |
28-438 |
8.18e-43 |
|
cystathionine gamma-synthase; Provisional
Pssm-ID: 169194 [Multi-domain] Cd Length: 386 Bit Score: 155.05 E-value: 8.18e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 28 PIYATTSYVFEnskhgsqlfGLEVP-GYVYSRFQNPTSNVLEERIAALEGGAAALAVSSGQAAQTLAIQGLAHTGDNIVS 106
Cdd:PRK08045 26 PIHLSSTYNFT---------GFNEPrAHDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAIHLVTTVFLKPGDLLVA 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 107 TSYLYGGTYNQFKISFKRFGIEARFVEGDNPEEFEKVFDERTKAVYLETIGNPKYNVPDFEKIVAIAHKHGIPVVVDNTF 186
Cdd:PRK08045 97 PHDCYGGSYRLFDSLAKRGCYRVLFVDQGDEQALRAALAEKPKLVLVESPSNPLLRVVDIAKICHLAREAGAVSVVDNTF 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 187 GAGGyFCQPIKYGADIVTHSATKWigghgtTIGGIIVDSGKFPWKDyPEkfpqfsqpaegyhgtiyneaygnlayivhVR 266
Cdd:PRK08045 177 LSPA-LQNPLALGADLVLHSCTKY------LNGHSDVVAGVVIAKD-PD-----------------------------VV 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 267 TELL---RDLGPLMNPFASFLLLQGVETLSLRAERHGENALKLAKWLEQSPYVSWVSYPGLASHSHHENAKKYLSnGFGG 343
Cdd:PRK08045 220 TELAwwaNNIGVTGGAFDSYLLLRGLRTLVPRMELAQRNAQAIVKYLQTQPLVKKLYHPSLPENQGHEIAARQQK-GFGA 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 344 VLSFGVkdlpNADKETDPFKLSGaqvvdnLKLASNLANVGDAKTLVIAPYFTTHKQLNDKEKLASGVTKDLIRVSVGIEF 423
Cdd:PRK08045 299 MLSFEL----DGDEQTLRRFLGG------LSLFTLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTGIED 368
|
410
....*....|....*
gi 6323333 424 IDDIIADFQQSFETV 438
Cdd:PRK08045 369 GEDLIADLENGFRAA 383
|
|
| PLN02242 |
PLN02242 |
methionine gamma-lyase |
29-421 |
3.88e-40 |
|
methionine gamma-lyase
Pssm-ID: 215134 Cd Length: 418 Bit Score: 148.37 E-value: 3.88e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 29 IYATTSYVFENSKHGSQLF----GLEVPGYVYSRFQNPTSNVLEERIAALEGGAAALAVSSGQAAQTLAIQGLAHTGDNI 104
Cdd:PLN02242 39 IEASATFTVMEPDTMRRMFsgelGPDRDFYIYSRHFNPTVLNLGRQMAALEGTEAAYCTASGMSAISSVLLQLCSSGGHV 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 105 VSTSYLYGGTYNQFKISFKR-FGIEARFVEGDNPEEFEKVFDE-RTKAVYLETIGNPKYNVPDFEKIVAIAHKHGIPVVV 182
Cdd:PLN02242 119 VASNTLYGGTHALLAHFLPRkCNITTTFVDITDLEAVKKAVVPgKTKVLYFESISNPTLTVADIPELARIAHEKGVTVVV 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 183 DNTFGAggYFCQPIKYGADIVTHSATKWigghgttiggiivdsgkfpwkdypekfpqFSQPAEGYHGTIYNEaygnlAYI 262
Cdd:PLN02242 199 DNTFAP--MVLSPARLGADVVVHSISKF-----------------------------ISGGADIIAGAVCGP-----AEL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 263 VHVRTEL----LRDLGPLMNPFASFLLLQGVETLSLRAERHGENALKLAKWLEQSPYVswVSYPGLASHSHHENAKKyLS 338
Cdd:PLN02242 243 VNSMMDLhhgaLMLLGPTMNPKVAFELSERLPHLSLRMKEHCRRAMEYAKRMKELGLK--VIYPGLEDHPQHALLKS-MA 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 339 N---GFGGVLSFgvkdlpnaDKETDpfklSGAQvvdnlKLASNLANV----------GDAKTLVIAPYFTTHKQLNDKEK 405
Cdd:PLN02242 320 NkgyGFGGLLCL--------DMDTE----ERAN-----RLMRYLQNStqfgfmavslGYYETLMSCSGSSTSSELDPEEK 382
|
410
....*....|....*.
gi 6323333 406 LASGVTKDLIRVSVGI 421
Cdd:PLN02242 383 AAAGISPGLVRMSVGY 398
|
|
| PRK05967 |
PRK05967 |
cystathionine beta-lyase; Provisional |
54-435 |
5.57e-34 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 235657 [Multi-domain] Cd Length: 395 Bit Score: 131.08 E-value: 5.57e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 54 YVYSRFQNPTSNVLEERIAALEGGAAALAVSSGQAAQTLAIQGLAHTGDNIVSTSYLYGGTYNQFKISFKRFGIEarfVE 133
Cdd:PRK05967 56 YTYGTRGTPTTDALCKAIDALEGSAGTILVPSGLAAVTVPFLGFLSPGDHALIVDSVYYPTRHFCDTMLKRLGVE---VE 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 134 GDNPE---EFEKVFDERTKAVYLETIGNPKYNVPDFEKIVAIAHKHGIPVVVDNTFGAGGYFcQPIKYGADIVTHSATKw 210
Cdd:PRK05967 133 YYDPEigaGIAKLMRPNTKVVHTEAPGSNTFEMQDIPAIAEAAHRHGAIVMMDNTWATPLYF-RPLDFGVDISIHAATK- 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 211 igghgttiggiivdsgkfpwkdYPekfpqfSQPAEGYHGTIY-NEAYGNLAYIVHVrtellrDLGPLMNPFASFLLLQGV 289
Cdd:PRK05967 211 ----------------------YP------SGHSDILLGTVSaNEKCWPQLLEAHG------TLGLCAGPDDTYQILRGL 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 290 ETLSLRAERHGENALKLAKWLEQSPYVSWVSYPGLASHSHHENAKKYLSnGFGGVLSFGVK-DLPNADKETDPFklsgaq 368
Cdd:PRK05967 257 RTMGIRLEHHRKSALEIARWLEGRPDVARVLHPALPSFPGHEIWKRDFS-GASGIFSFVLAaGPEKGKAKAHAF------ 329
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6323333 369 vVDNLKLASNLANVGDAKTLVIapyfttHKQLNDKeKLASGVTKD-LIRVSVGIEFIDDIIADFQQSF 435
Cdd:PRK05967 330 -LDALEIFGLGYSWGGYESLAL------HVKLGDR-TVAKAPYAGpVIRLQIGLEDVPDLKADLERGF 389
|
|
| PRK07050 |
PRK07050 |
cystathionine beta-lyase; Provisional |
1-440 |
1.65e-30 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 180810 [Multi-domain] Cd Length: 394 Bit Score: 121.37 E-value: 1.65e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 1 MPSHFDTVQLHAGQENPgdNAHRSRAVPIYATTSYVFENSKHGSQLFGLEVPGYVYSRFQNPTSNVLEERIAALEGGAAA 80
Cdd:PRK07050 6 PKRALQTRIVQPDDQIP--PGFRSFVTPVARASTVVFPDLATMRALDWRQDVQWRYGLHATPTSLALAQRLAEIEGGRHA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 81 LAVSSGQAAQTLAIQGLAHTGDNIVSTSYLYGGTYNQFKISFKRFGIEARFVEGDNPEEFEKVFDERTKAVYLETIGNPK 160
Cdd:PRK07050 84 LLQPSGLAAISLVYFGLVKAGDDVLIPDNAYGPNRDHGEWLARDFGITVRFYDPLIGAGIADLIQPNTRLIWLEAPGSVT 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 161 YNVPDFEKIVAIAHKHGIPVVVDNTFGAGGYFcQPIKYGADIVTHSATKWIgghgttiggiivdSGKfpwkdypekfpqf 240
Cdd:PRK07050 164 MEVPDVPAITAAARARGVVTAIDNTYSAGLAF-KPFEHGVDISVQALTKYQ-------------SGG------------- 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 241 SQPAEGyhGTIYNEAYgnlayiVHVRTELLR-DLGPLMNPFASFLLLQGVETLSLRAERHGENALKLAKWLEQSPYVSWV 319
Cdd:PRK07050 217 SDVLMG--ATITADAE------LHAKLKLARmRLGIGVSADDCSLVLRGLPSLQVRLAAHDRSALEVAEWLKARPEIATV 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 320 SYPGLASHSHHENAKKYLSnGFGGVLSFGVKDLPNAdKETDPFklsgaqvVDNLKLASNLANVGDAKTLVIaPYfttHKQ 399
Cdd:PRK07050 289 LHPALPDCPGHAFWMRDFT-GAGGLFSVVFDERYSP-AQVDAF-------VEALELFAIGWSWGGACSLAM-PY---DVA 355
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 6323333 400 LNDKEKLASGVTkdLIRVSVGIEFIDDIIADFQQSFETVFA 440
Cdd:PRK07050 356 SMRTAKWPHRGT--LVRLYIGLEDEADLIADLEQALEAALA 394
|
|
| PRK07582 |
PRK07582 |
cystathionine gamma-lyase; Validated |
48-434 |
7.16e-30 |
|
cystathionine gamma-lyase; Validated
Pssm-ID: 236061 Cd Length: 366 Bit Score: 119.33 E-value: 7.16e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 48 GLEVPGYVYSRFQNPTSNVLEERIAALEGGAAALaVSSGQAAQTLAIQGLAHTGDNIVSTSYLYGGTYNQFKISFKRFGI 127
Cdd:PRK07582 37 GEPTGPDTYGRASNPTWRALEAALGELEGAEALV-FPSGMAAITAVLRALLRPGDTVVVPADGYYQVRALAREYLAPLGV 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 128 EARFVEgdNPEEFEKVFDeRTKAVYLETIGNPKYNVPDFEKIVAIAHKHGIPVVVDNT----FGAggyfcQPIKYGADIV 203
Cdd:PRK07582 116 TVREAP--TAGMAEAALA-GADLVLAETPSNPGLDVCDLAALAAAAHAAGALLVVDNTtatpLGQ-----RPLELGADLV 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 204 THSATKwigghgttiggiivdsgkfpwkdypekfpqfsqpAEGYHGTIYneaygnLAYIVHVRTELL------RDL-GPL 276
Cdd:PRK07582 188 VASDTK----------------------------------ALTGHSDLL------LGYVAGRDPELMaaverwRLLaGAI 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 277 MNPFASFLLLQGVETLSLRAERHGENALKLAKWLEQSPYVSWVSYPGLASHSHHENAKKYLSnGFGGVLSFgvkDLPNAD 356
Cdd:PRK07582 228 PGPFEAWLAHRSLGTLGLRFARQCANALAVAELLAGHPAVRGVRYPGLPGDPAHEVAARQMR-RFGGLVSF---ELADAA 303
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6323333 357 KetdpfklsGAQVVDNLKLasnlanvgdaktLVIAPYF-TTHKQLNDKEKLASGVTKDLIRVSVGIEFIDDIIADFQQS 434
Cdd:PRK07582 304 A--------AERFVAASRL------------VVAATSFgGVHTSADRRARWGDAVPEGFVRLSCGIEDTDDLVADLERA 362
|
|
| PRK09028 |
PRK09028 |
cystathionine beta-lyase; Provisional |
85-436 |
6.01e-26 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 181615 [Multi-domain] Cd Length: 394 Bit Score: 108.67 E-value: 6.01e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 85 SGQAAQTLAIQGLAHTGDNIVSTSYLYGGTYNQFKISFKRFGIEARFVEGDNPEEFEKVFDERTKAVYLETIGNPKYNVP 164
Cdd:PRK09028 84 SGAAAISNALLSFLKAGDHLLMVDSCYEPTRDLCDKILKGFGIETTYYDPMIGEGIRELIRPNTKVLFLESPGSITMEVQ 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 165 DFEKIVAIAHKHGIPVVVDNTFGAGGYFcQPIKYGADIVTHSATKWIGghgttiggiivdsgkfpwkdypekfpqfsqpa 244
Cdd:PRK09028 164 DVPTLSRIAHEHDIVVMLDNTWASPINS-RPFEMGVDISIQAATKYIV-------------------------------- 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 245 eGYHGTIYNEAYGNLAYivhvrTELLRDLGPLMNPFAS----FLLLQGVETLSLRAERHGENALKLAKWLEQSPYVSWVS 320
Cdd:PRK09028 211 -GHSDVMLGTATANEKH-----WDQLREHSYLMGQCTSpddvYLAMRGLRTLGVRLAQHEKNALKVANWLATRPEVDHVR 284
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 321 YPGLASHSHHENAKKYLSnGFGGVLSFGVkdlpnadKETDPFKLSGaqVVDNLKLASNLANVGDAKTLVIApyfttHKQL 400
Cdd:PRK09028 285 HPAFETCPGHEFFKRDFS-GSNGLFSFVL-------KQGDPKAVTA--LVEGMQHFKMGFSWGGFESLILG-----VFGI 349
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 6323333 401 NdkeKLASGVTKD----LIRVSVGIEFIDDIIADFQQSFE 436
Cdd:PRK09028 350 N---KLRTATNWDfskpLIRLHIGLEDVDDLIADLEAGFE 386
|
|
| PRK08114 |
PRK08114 |
cystathionine beta-lyase; Provisional |
85-436 |
1.03e-23 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 181231 [Multi-domain] Cd Length: 395 Bit Score: 102.09 E-value: 1.03e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 85 SGQAAQTLAIQGLAHTGDNIVSTSYLYGGTYNQFKISFKRFGIEARFVEGDNPEEFEKVFDERTKAVYLETIGNPKYNVP 164
Cdd:PRK08114 85 CGAAAVANAILAFVEQGDHVLMTGTAYEPTQDFCSKILSKLGVTTTWFDPLIGADIAKLIQPNTKVVFLESPGSITMEVH 164
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 165 DFEKIVAIAHKHG--IPVVVDNTFGAGGYFcQPIKYGADIVTHSATKWIGghgttiggiivdsgkfpwkdypekfpqfsq 242
Cdd:PRK08114 165 DVPAIVAAVRSVNpdAVIMIDNTWAAGVLF-KALDFGIDISIQAGTKYLV------------------------------ 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 243 paeGYHGTIYNEAYGNlayivhVRT-ELLRDLGPLMNPFA----SFLLLQGVETLSLRAERHGENALKLAKWLEQSPYVS 317
Cdd:PRK08114 214 ---GHSDAMIGTAVAN------ARCwEQLRENSYLMGQMVdadtAYMTSRGLRTLGVRLRQHEESSLKVAEWLAEHPEVA 284
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 318 WVSYPGLASHSHHENAKKYLSnGFGGVLSFGVKDlpnadketdpfKLSGAQV---VDNLKLASNLANVGDAKTLVIApyf 394
Cdd:PRK08114 285 RVNHPALPGCKGHEFWKRDFT-GSSGLFSFVLKK-----------KLTDEQLanyLDNFSLFSMAYSWGGFESLILA--- 349
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 6323333 395 tthkqlNDKEKLAS-------GVTKDLIRVSVGIEFIDDIIADFQQSFE 436
Cdd:PRK08114 350 ------NQPEEIAAirpagevDFTGTLIRLHIGLEDVDDLIADLAAGFA 392
|
|
| AAT_I |
cd01494 |
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ... |
83-210 |
2.42e-10 |
|
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).
Pssm-ID: 99742 [Multi-domain] Cd Length: 170 Bit Score: 59.32 E-value: 2.42e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 83 VSSGQAAQTLAIQGLAHTGDNIVSTSYLYGGTYNqfkISFKRFGIEARFVEGDNPEEFEKVFD--------ERTKAVYLE 154
Cdd:cd01494 23 VPSGTGANEAALLALLGPGDEVIVDANGHGSRYW---VAAELAGAKPVPVPVDDAGYGGLDVAileelkakPNVALIVIT 99
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 6323333 155 TIGNPKYNVPDFEKIVAIAHKHGIPVVVDNTFGAGGYFCQPIK---YGADIVTHSATKW 210
Cdd:cd01494 100 PNTTSGGVLVPLKEIRKIAKEYGILLLVDAASAGGASPAPGVLipeGGADVVTFSLHKN 158
|
|
| AAT_like |
cd00609 |
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent ... |
92-209 |
8.89e-10 |
|
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. The major groups in this CD corresponds to Aspartate aminotransferase a, b and c, Tyrosine, Alanine, Aromatic-amino-acid, Glutamine phenylpyruvate, 1-Aminocyclopropane-1-carboxylate synthase, Histidinol-phosphate, gene products of malY and cobC, Valine-pyruvate aminotransferase and Rhizopine catabolism regulatory protein.
Pssm-ID: 99734 [Multi-domain] Cd Length: 350 Bit Score: 60.05 E-value: 8.89e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 92 LAIQGLAHTGDNIVSTSYlyggTYNQFKISFKRFGIEARFVE-------GDNPEEFEKVFDERTKAVYLETIGNP---KY 161
Cdd:cd00609 74 LLLRALLNPGDEVLVPDP----TYPGYEAAARLAGAEVVPVPldeeggfLLDLELLEAAKTPKTKLLYLNNPNNPtgaVL 149
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 6323333 162 NVPDFEKIVAIAHKHGIPVVVDNTFG--AGGYFCQPIKYGAD-----IVTHSATK 209
Cdd:cd00609 150 SEEELEELAELAKKHGILIISDEAYAelVYDGEPPPALALLDayervIVLRSFSK 204
|
|
| Aminotran_1_2 |
pfam00155 |
Aminotransferase class I and II; |
83-191 |
6.36e-09 |
|
Aminotransferase class I and II;
Pssm-ID: 395103 [Multi-domain] Cd Length: 351 Bit Score: 57.32 E-value: 6.36e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 83 VSSG-QAAQTLAIQGLAHTGDNIVSTSYlyggTYNQFKISFKRFGIEARFVEGDNPEEF-------EKVFDERTKAVYLE 154
Cdd:pfam00155 68 FGSGaGANIEALIFLLANPGDAILVPAP----TYASYIRIARLAGGEVVRYPLYDSNDFhldfdalEAALKEKPKVVLHT 143
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 6323333 155 TIGNP---KYNVPDFEKIVAIAHKHGIPVVVDNTFGAGGY 191
Cdd:pfam00155 144 SPHNPtgtVATLEELEKLLDLAKEHNILLLVDEAYAGFVF 183
|
|
| CsdA |
COG0520 |
Selenocysteine lyase/Cysteine desulfurase [Amino acid transport and metabolism]; |
92-183 |
4.17e-08 |
|
Selenocysteine lyase/Cysteine desulfurase [Amino acid transport and metabolism];
Pssm-ID: 440286 [Multi-domain] Cd Length: 396 Bit Score: 55.15 E-value: 4.17e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 92 LAIQGLAH--TGDNIVSTSYLYGGTYNQFKISFKRFGIEARFVE-----GDNPEEFEKVFDERTKAVYLETIGNpkyN-- 162
Cdd:COG0520 92 LVAYGLGRlkPGDEILITEMEHHSNIVPWQELAERTGAEVRVIPldedgELDLEALEALLTPRTKLVAVTHVSN---Vtg 168
|
90 100
....*....|....*....|..
gi 6323333 163 -VPDFEKIVAIAHKHGIPVVVD 183
Cdd:COG0520 169 tVNPVKEIAALAHAHGALVLVD 190
|
|
| AHBA_syn |
cd00616 |
3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal ... |
83-188 |
9.24e-07 |
|
3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary metabolites. Some well studied proteins in this CD are AHBA_synthase, protein product of pleiotropic regulatory gene degT, Arnb aminotransferase and pilin glycosylation protein. The prototype of this family, the AHBA_synthase, is a dimeric PLP dependent enzyme. AHBA_syn is the terminal enzyme of 3-amino-5-hydroxybenzoic acid (AHBA) formation which is involved in the biosynthesis of ansamycin antibiotics, including rifamycin B. Some members of this CD are involved in 4-amino-6-deoxy-monosaccharide D-perosamine synthesis. Perosamine is an important element in the glycosylation of several cell products, such as antibiotics and lipopolysaccharides of gram-positive and gram-negative bacteria. The pilin glycosylation protein encoded by gene pglA, is a galactosyltransferase involved in pilin glycosylation. Additionally, this CD consists of ArnB (PmrH) aminotransferase, a 4-amino-4-deoxy-L-arabinose lipopolysaccharide-modifying enzyme. This CD also consists of several predicted pyridoxal phosphate-dependent enzymes apparently involved in regulation of cell wall biogenesis. The catalytic lysine which is present in all characterized PLP dependent enzymes is replaced by histidine in some members of this CD.
Pssm-ID: 99740 [Multi-domain] Cd Length: 352 Bit Score: 50.62 E-value: 9.24e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 83 VSSGQAAQTLAIQGL-AHTGDNIVSTSYLYGGTYNqfkiSFKRFGIEARFVEGD------NPEEFEKVFDERTKAV---- 151
Cdd:cd00616 39 VSSGTAALHLALRALgIGPGDEVIVPSFTFVATAN----AILLLGATPVFVDIDpdtyniDPELIEAAITPRTKAIipvh 114
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 6323333 152 -YletiGNPKynvpDFEKIVAIAHKHGIPVVVDN--TFGA 188
Cdd:cd00616 115 lY----GNPA----DMDAIMAIAKRHGLPVIEDAaqALGA 146
|
|
| Aminotran_5 |
pfam00266 |
Aminotransferase class-V; This domain is found in amino transferases, and other enzymes ... |
83-209 |
1.68e-06 |
|
Aminotransferase class-V; This domain is found in amino transferases, and other enzymes including cysteine desulphurase EC:4.4.1.-.
Pssm-ID: 425567 [Multi-domain] Cd Length: 368 Bit Score: 49.94 E-value: 1.68e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 83 VSSGQAAQTLAIQGLAHT---GDNIVSTSYLYGGTYNQFKISFKRFGIEARFVEGD-----NPEEFEKVFDERTKAVYLE 154
Cdd:pfam00266 67 TSGTTEAINLVALSLGRSlkpGDEIVITEMEHHANLVPWQELAKRTGARVRVLPLDedgllDLDELEKLITPKTKLVAIT 146
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 6323333 155 TIGNPKYNVPDFEKIVAIAHKHGIPVVVDntfGAGGYFCQPI---KYGADIVTHSATK 209
Cdd:pfam00266 147 HVSNVTGTIQPVPEIGKLAHQYGALVLVD---AAQAIGHRPIdvqKLGVDFLAFSGHK 201
|
|
| TA_like |
cd06502 |
Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP) ... |
62-209 |
2.50e-06 |
|
Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a secondary glycine biosynthetic pathway.
Pssm-ID: 99748 [Multi-domain] Cd Length: 338 Bit Score: 49.25 E-value: 2.50e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 62 PTSNVLEERIAALEGGAAALAVSSGQAAQTLAIQGLAHTGDNIV--STSYLYggTYNQFKISFKRfGIEARFVEGDN--- 136
Cdd:cd06502 32 PTTAKLEARAAELFGKEAALFVPSGTAANQLALAAHTQPGGSVIchETAHIY--TDEAGAPEFLS-GVKLLPVPGENgkl 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 137 -PEEFEK-------VFDERTKAVYLE--TIGNPKYNVPDFEKIVAIAHKHGIPVVVD-----NTFGAGGYFCQPIKYGAD 201
Cdd:cd06502 109 tPEDLEAairprddIHFPPPSLVSLEntTEGGTVYPLDELKAISALAKENGLPLHLDgarlaNAAAALGVALKTYKSGVD 188
|
....*...
gi 6323333 202 IVTHSATK 209
Cdd:cd06502 189 SVSFCLSK 196
|
|
| SufS_like |
cd06453 |
Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP) ... |
123-183 |
2.94e-06 |
|
Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine; and selenocysteine lyase catalyzes the decomposition of L-selenocysteine.
Pssm-ID: 99746 [Multi-domain] Cd Length: 373 Bit Score: 49.00 E-value: 2.94e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6323333 123 KRFGIEARFVEGD-----NPEEFEKVFDERTKAVYLETIGNPKYNVPDFEKIVAIAHKHGIPVVVD 183
Cdd:cd06453 110 ERTGAKLKVVPVDddgqlDLEALEKLLTERTKLVAVTHVSNVLGTINPVKEIGEIAHEAGVPVLVD 175
|
|
| Orn_deC_like |
cd00615 |
Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent ... |
134-209 |
3.86e-06 |
|
Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine decarboxylase (LDC). ODC is a dodecamer composed of six homodimers and catalyzes the decarboxylation of tryptophan. ADC catalyzes the decarboxylation of arginine and LDC catalyzes the decarboxylation of lysine. Members of this family are widely found in all three forms of life.
Pssm-ID: 99739 [Multi-domain] Cd Length: 294 Bit Score: 48.40 E-value: 3.86e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 134 GDNPEEFEKVFDERTKAVYLeTIGNPKYN--VPDFEKIVAIAHKHGIPVVVDNTFGAggYFC-------QPIKYGADIVT 204
Cdd:cd00615 139 GIPPETFKKALIEHPDAKAA-VITNPTYYgiCYNLRKIVEEAHHRGLPVLVDEAHGA--HFRfhpilpsSAAMAGADIVV 215
|
....*
gi 6323333 205 HSATK 209
Cdd:cd00615 216 QSTHK 220
|
|
| Beta_elim_lyase |
pfam01212 |
Beta-eliminating lyase; |
61-209 |
6.64e-06 |
|
Beta-eliminating lyase;
Pssm-ID: 426128 [Multi-domain] Cd Length: 288 Bit Score: 47.60 E-value: 6.64e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 61 NPTSNVLEERIAALEGGAAALAVSSGQAAQTLAIQGLAHTGDNIV----STSYLY-GGTYNQFKisfkrfGIEARFVEGD 135
Cdd:pfam01212 31 DPTVNRLEDRVAELFGKEAALFVPSGTAANQLALMAHCQRGDEVIcgepAHIHFDeTGGHAELG------GVQPRPLDGD 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 136 N-----PEEFEKVFDE-------RTKAVYLE----TIGNPKYNVPDFEKIVAIAHKHGIPVVVDNT--FGAGGYFCQPIK 197
Cdd:pfam01212 105 EagnmdLEDLEAAIREvgadifpPTGLISLEnthnSAGGQVVSLENLREIAALAREHGIPVHLDGArfANAAVALGVIVK 184
|
170
....*....|....*
gi 6323333 198 ---YGADIVTHSATK 209
Cdd:pfam01212 185 eitSYADSVTMCLSK 199
|
|
| WecE |
COG0399 |
dTDP-4-amino-4,6-dideoxygalactose transaminase [Cell wall/membrane/envelope biogenesis]; |
83-188 |
1.23e-05 |
|
dTDP-4-amino-4,6-dideoxygalactose transaminase [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440168 Cd Length: 364 Bit Score: 46.99 E-value: 1.23e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 83 VSSGQAAQTLAIQGLA-HTGDNIVSTSYLYGGTYNqfkiSFKRFGIEARFVEGD------NPEEFEKVFDERTKAV---- 151
Cdd:COG0399 51 VSSGTAALHLALRALGiGPGDEVITPAFTFVATAN----AILYVGATPVFVDIDpdtyniDPEALEAAITPRTKAIipvh 126
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 6323333 152 -YletiGNPkynvPDFEKIVAIAHKHGIPVVVDN--TFGA 188
Cdd:COG0399 127 lY----GQP----ADMDAIMAIAKKHGLKVIEDAaqALGA 158
|
|
| AspB |
COG0436 |
Aspartate/methionine/tyrosine aminotransferase [Amino acid transport and metabolism]; ... |
92-184 |
2.88e-05 |
|
Aspartate/methionine/tyrosine aminotransferase [Amino acid transport and metabolism]; Aspartate/methionine/tyrosine aminotransferase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis
Pssm-ID: 440205 [Multi-domain] Cd Length: 387 Bit Score: 45.89 E-value: 2.88e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 92 LAIQGLAHTGDNIVSTSYLYGgTYNQFkisFKRFGIEARFVEGD-------NPEEFEKVFDERTKAVYLETIGNP---KY 161
Cdd:COG0436 105 LALLALLNPGDEVLVPDPGYP-SYRAA---VRLAGGKPVPVPLDeengflpDPEALEAAITPRTKAIVLNSPNNPtgaVY 180
|
90 100
....*....|....*....|...
gi 6323333 162 NVPDFEKIVAIAHKHGIPVVVDN 184
Cdd:COG0436 181 SREELEALAELAREHDLLVISDE 203
|
|
| SepCysS |
cd06452 |
Sep-tRNA:Cys-tRNA synthase. This family belongs to the pyridoxal phosphate (PLP)-dependent ... |
93-209 |
5.30e-05 |
|
Sep-tRNA:Cys-tRNA synthase. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Cys-tRNA(Cys) is produced by O-phosphoseryl-tRNA synthetase which ligates O-phosphoserine (Sep) to tRNA(Cys), and Sep-tRNA:Cys-tRNA synthase (SepCysS) converts Sep-tRNA(Cys) to Cys-tRNA(Cys), in methanogenic archaea. SepCysS forms a dimer, each monomer is composed of a large and small domain; the larger, a typical pyridoxal 5'-phosphate (PLP)-dependent-like enzyme fold. In the active site of each monomer, PLP is covalently bound to a conserved Lys residue near the dimer interface.
Pssm-ID: 99745 Cd Length: 361 Bit Score: 45.07 E-value: 5.30e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 93 AIQGLAHTGDNIVSTSYLYGGTYnqfkISFKRFGIEARFVEGD-------NPEEF----EKVFDERTKAVYLETIGNPKY 161
Cdd:cd06452 75 VMHSLCEKGDWVVVDGLAHYTSY----VAAERAGLNVREVPNTghpeyhiTPEGYaeviEEVKDEFGKPPALALLTHVDG 150
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 6323333 162 ---NVPDFEKIVAIAHKHGIPVVVDNTFGAGGYFCQPIKYGADIVTHSATK 209
Cdd:cd06452 151 nygNLHDAKKIAKVCHEYGVPLLLNGAYTVGRMPVSGKELGADFIVGSGHK 201
|
|
| PRK07568 |
PRK07568 |
pyridoxal phosphate-dependent aminotransferase; |
86-183 |
9.85e-05 |
|
pyridoxal phosphate-dependent aminotransferase;
Pssm-ID: 181036 Cd Length: 397 Bit Score: 44.46 E-value: 9.85e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 86 GQAAQTLAIQGLAHTGDNIVSTSYLYGgTYNQFKISF--KRFGIEARFVEG---DNPEEFEKVFDERTKAVYLETIGNPK 160
Cdd:PRK07568 97 GSEAILFAMMAICDPGDEILVPEPFYA-NYNGFATSAgvKIVPVTTKIEEGfhlPSKEEIEKLITPKTKAILISNPGNPT 175
|
90 100
....*....|....*....|....*.
gi 6323333 161 ---YNVPDFEKIVAIAHKHGIPVVVD 183
Cdd:PRK07568 176 gvvYTKEELEMLAEIAKKHDLFLISD 201
|
|
| SelA |
COG1921 |
Seryl-tRNA(Sec) selenium transferase [Translation, ribosomal structure and biogenesis]; |
164-209 |
1.53e-04 |
|
Seryl-tRNA(Sec) selenium transferase [Translation, ribosomal structure and biogenesis];
Pssm-ID: 441524 Cd Length: 399 Bit Score: 43.96 E-value: 1.53e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 6323333 164 PDFEKIVAIAHKHGIPVVVDntFGAG--------GYFCQP-----IKYGADIVTHSATK 209
Cdd:COG1921 175 VSLAELAELAHEHGLPVIVD--LGSGslvdlskyGLPHEPtvqeyLAAGADLVTFSGDK 231
|
|
| DegT_DnrJ_EryC1 |
pfam01041 |
DegT/DnrJ/EryC1/StrS aminotransferase family; The members of this family are probably all ... |
83-183 |
1.61e-04 |
|
DegT/DnrJ/EryC1/StrS aminotransferase family; The members of this family are probably all pyridoxal-phosphate-dependent aminotransferase enzymes with a variety of molecular functions. The family includes StsA, StsC and StsS. The aminotransferase activity was demonstrated for purified StsC protein as the L-glutamine:scyllo-inosose aminotransferase EC:2.6.1.50, which catalyzes the first amino transfer in the biosynthesis of the streptidine subunit of streptomycin.
Pssm-ID: 395827 Cd Length: 360 Bit Score: 43.81 E-value: 1.61e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 83 VSSGQAAQTLAIQGL-AHTGDNIVSTSYLYGGTYNqfkiSFKRFGIEARFVEGD------NPEEFEKVFDERTKAVYLET 155
Cdd:pfam01041 45 VSSGTAALHLALRALgVGPGDEVITPSFTFVATAN----AALRLGAKPVFVDIDpdtyniDPEAIEAAITPRTKAIIPVH 120
|
90 100
....*....|....*....|....*....
gi 6323333 156 I-GNPKynvpDFEKIVAIAHKHGIPVVVD 183
Cdd:pfam01041 121 LyGQPA----DMDAIRAIAARHGLPVIED 145
|
|
| PRK09331 |
PRK09331 |
Sep-tRNA:Cys-tRNA synthetase; Provisional |
138-209 |
8.30e-04 |
|
Sep-tRNA:Cys-tRNA synthetase; Provisional
Pssm-ID: 236469 Cd Length: 387 Bit Score: 41.45 E-value: 8.30e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6323333 138 EEFEKVFDERTKAVYLETIGNPKY---NVPDFEKIVAIAHKHGIPVVVDNTFGAGgyfCQPI---KYGADIVTHSATK 209
Cdd:PRK09331 146 EKIEEVKEETGKPPALALLTHVDGnygNLADAKKVAKVAHEYGIPFLLNGAYTVG---RMPVdgkKLGADFIVGSGHK 220
|
|
| tyr_nico_aTase |
TIGR01265 |
tyrosine/nicotianamine family aminotransferase; This subfamily of pyridoxal ... |
84-187 |
1.70e-03 |
|
tyrosine/nicotianamine family aminotransferase; This subfamily of pyridoxal phosphate-dependent enzymes includes known examples of both tyrosine aminotransferase from animals and nicotianamine aminotransferase from barley.
Pssm-ID: 188123 Cd Length: 403 Bit Score: 40.40 E-value: 1.70e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 84 SSGQAAQTLAIQGLAHTGDNIVstsyLYGGTYNQFKISFKRFGIEARF--------VEGDnPEEFEKVFDERTKAVYLET 155
Cdd:TIGR01265 103 SGCSQAIEICIEALANPGANIL----VPRPGFPLYDTRAAFSGLEVRLydllpekdWEID-LDGLESLADEKTVAIVVIN 177
|
90 100 110
....*....|....*....|....*....|....*
gi 6323333 156 IGNPKYNVPD---FEKIVAIAHKHGIPVVVDNTFG 187
Cdd:TIGR01265 178 PSNPCGSVFSrdhLQKIAEVAEKLGIPIIADEIYG 212
|
|
| AGAT_like |
cd06451 |
Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate ... |
84-203 |
1.92e-03 |
|
Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT), serine-glyoxylate aminotransferase (SGAT), and 3-hydroxykynurenine transaminase (HKT). AGAT is a homodimeric protein, which catalyses the transamination of glyoxylate to glycine, and SGAT converts serine and glyoxylate to hydroxypyruvate and glycine. HKT catalyzes the PLP-dependent transamination of 3-hydroxykynurenine, a potentially toxic metabolite of the kynurenine pathway.
Pssm-ID: 99744 [Multi-domain] Cd Length: 356 Bit Score: 40.35 E-value: 1.92e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 84 SSGQAAQTLAIQGLAHTGDNIVSTSYlygGTYNQ-FKISFKRFGIEARFVEGD-----NPEEFEKVFDERT-KAVYL--- 153
Cdd:cd06451 57 GSGTGAMEAALSNLLEPGDKVLVGVN---GVFGDrWADMAERYGADVDVVEKPwgeavSPEEIAEALEQHDiKAVTLthn 133
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 6323333 154 ET---IGNPkynvpdFEKIVAIAHKHGIPVVVDNTFGAGGYFCQPIKYGADIV 203
Cdd:cd06451 134 ETstgVLNP------LEGIGALAKKHDALLIVDAVSSLGGEPFRMDEWGVDVA 180
|
|
| PucG |
COG0075 |
Archaeal aspartate aminotransferase or a related aminotransferase, includes purine catabolism ... |
123-203 |
2.48e-03 |
|
Archaeal aspartate aminotransferase or a related aminotransferase, includes purine catabolism protein PucG [Amino acid transport and metabolism, Nucleotide transport and metabolism]; Archaeal aspartate aminotransferase or a related aminotransferase, includes purine catabolism protein PucG is part of the Pathway/BioSystem: Serine biosynthesis
Pssm-ID: 439845 [Multi-domain] Cd Length: 376 Bit Score: 40.07 E-value: 2.48e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 123 KRFGIEARFVEGD-----NPEEFEKVFDE--RTKAVYL---ET---IGNPkynvpdFEKIVAIAHKHGIPVVVDNTFGAG 189
Cdd:COG0075 94 ERYGAEVVVLEVPwgeavDPEEVEEALAAdpDIKAVAVvhnETstgVLNP------LEEIGALAKEHGALLIVDAVSSLG 167
|
90
....*....|....*..
gi 6323333 190 GYfcqPIK---YGADIV 203
Cdd:COG0075 168 GV---PLDmdeWGIDVV 181
|
|
| PRK00451 |
PRK00451 |
aminomethyl-transferring glycine dehydrogenase subunit GcvPA; |
145-203 |
2.58e-03 |
|
aminomethyl-transferring glycine dehydrogenase subunit GcvPA;
Pssm-ID: 234769 [Multi-domain] Cd Length: 447 Bit Score: 40.12 E-value: 2.58e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 145 DERTKAVYLEtigNPKY--NVPDFEKIVAIAHKHGIPVVVdntfgaggyFCQPI---------KYGADIV 203
Cdd:PRK00451 202 DDDTAAVVVQ---YPNFfgVIEDLEEIAEIAHAGGALFIV---------GVDPVslgllkppgEYGADIV 259
|
|
| PRK07550 |
PRK07550 |
aminotransferase; |
89-190 |
2.87e-03 |
|
aminotransferase;
Pssm-ID: 181026 [Multi-domain] Cd Length: 386 Bit Score: 39.56 E-value: 2.87e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 89 AQTLAIQGLAHTGDNIVSTSYLYggtYNQfKISFKRFGIEARFVEGD-------NPEEFEKVFDERTKAVYLETIGNPKY 161
Cdd:PRK07550 102 AFWAAMVTLAGAGDEVILPLPWY---FNH-KMWLDMLGIRPVYLPCDegpgllpDPAAAEALITPRTRAIALVTPNNPTG 177
|
90 100 110
....*....|....*....|....*....|....*
gi 6323333 162 NV--PD-FEKIVAIAHKHGIPVVVDNT---FGAGG 190
Cdd:PRK07550 178 VVypPElLHELYDLARRHGIALILDETyrdFDSGG 212
|
|
| tyr_amTase_E |
TIGR01264 |
tyrosine aminotransferase, eukaryotic; This model describes tyrosine aminotransferase as found ... |
84-187 |
3.10e-03 |
|
tyrosine aminotransferase, eukaryotic; This model describes tyrosine aminotransferase as found in animals and Trypanosoma cruzi. It is the first enzyme of a pathway of tyrosine degradation via homogentisate. Several plant enzyme designated as probable tyrosine aminotransferases are very closely related to an experimentally demonstrated nicotianamine aminotransferase, an enzyme in a siderophore (iron uptake chelator) biosynthesis pathway. These plant sequences are excluded from the model seed and score between the trusted an noise cutoffs. [Energy metabolism, Amino acids and amines]
Pssm-ID: 273529 [Multi-domain] Cd Length: 401 Bit Score: 39.77 E-value: 3.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 84 SSGQAAQTLAIQGLAHTGDNIVSTSylygGTYNQFKISFKRFGIEARF--------VEGDnPEEFEKVFDERTKAVYLET 155
Cdd:TIGR01264 102 SGCSHAIEMCIAALANAGQNILVPR----PGFPLYETLAESMGIEVKLynllpdksWEID-LKQLESLIDEKTAALIVNN 176
|
90 100 110
....*....|....*....|....*....|....*
gi 6323333 156 IGNPKYNVPD---FEKIVAIAHKHGIPVVVDNTFG 187
Cdd:TIGR01264 177 PSNPCGSVFSrqhLEEILAVAERQCLPIIADEIYG 211
|
|
| PRK07682 |
PRK07682 |
aminotransferase; |
136-183 |
6.36e-03 |
|
aminotransferase;
Pssm-ID: 181082 [Multi-domain] Cd Length: 378 Bit Score: 38.56 E-value: 6.36e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 6323333 136 NPEEFEKVFDERTKAVYLETIGNPK---YNVPDFEKIVAIAHKHGIPVVVD 183
Cdd:PRK07682 143 QPAQIEAAITAKTKAILLCSPNNPTgavLNKSELEEIAVIVEKHDLIVLSD 193
|
|
| PBP1_ABC_unchar_transporter |
cd06325 |
type 1 periplasmic ligand-binding domain of uncharacterized ABC-type transport systems ... |
116-201 |
9.89e-03 |
|
type 1 periplasmic ligand-binding domain of uncharacterized ABC-type transport systems predicted to be involved in uptake of amino acids, peptides, or inorganic ions; This group includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); its ligand specificity has not been determined experimentally.
Pssm-ID: 380548 Cd Length: 282 Bit Score: 37.87 E-value: 9.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323333 116 NQFKISFKRFGIEARFVEGDNPEEFEKVFD----ERTKAVYLetignpkynVPD------FEKIVAIAHKHGIPVVVDNT 185
Cdd:cd06325 150 EELEAAAKKLGLELVEVPVSSPADIEQAFAslagKVADALYV---------PTDntvasaRPRIAALALKARIPVIYSDR 220
|
90
....*....|....*...
gi 6323333 186 FG--AGGYFCqpikYGAD 201
Cdd:cd06325 221 EFveAGALMS----YGPD 234
|
|
| |
