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Conserved domains on  [gi|94158994|ref|NP_031492|]
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apoptosis inhibitor 5 isoform 2 [Mus musculus]

Protein Classification

API5 domain-containing protein( domain architecture ID 10531332)

API5 domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
API5 pfam05918
Apoptosis inhibitory protein 5 (API5); This family consists of apoptosis inhibitory protein 5 ...
4-503 0e+00

Apoptosis inhibitory protein 5 (API5); This family consists of apoptosis inhibitory protein 5 (API5) sequences from several organizms. Apoptosis or programmed cell death is a physiological form of cell death that occurs in embryonic development and organ formation. It is characterized by biochemical and morphological changes such as DNA fragmentation and cell volume shrinkage. API5 is an anti apoptosis gene located in human chromosome 11, whose expression prevents the programmed cell death that occurs upon the deprivation of growth factors and is up-regulated in various cancer cells. This protein has an elongated all alpha-helical structure, in which the N-terminal half is similar to the HEAT repeat and the C-terminal half is similar to the ARM (Armadillo-like) repeat. This suggests that API5 is involved in protein-protein interactions and may act as a scaffold for multiprotein complexes.


:

Pssm-ID: 428672 [Multi-domain]  Cd Length: 532  Bit Score: 656.38  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94158994     4 VEELYRNYGILADATEQVGQHKDAYQVILDGVKGGTKEKRLAAQFIPKFFKHFPELADSAINAQLDLCEDEDVSIRRQAI 83
Cdd:pfam05918   1 IEKLYENYEILNDAKDKISEHEEDYLGILDAVKGSAKEKQLASQFIPKFFKFFPSLANTAIDAQLDLCEDDDLGVRVQAI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94158994    84 KELPQFATG--ENLPRVADILTQLLQTDDSAEFNLVNNALLSIFKMDAKGTLGGLFSQILQGEDIVRERAIKFLSTKLKT 161
Cdd:pfam05918  81 KGLPLLCKDnpEYVPKIVDILGQLLNTEDPVERDAVHKALMSLLKQDTKASLTGLFKQIETGDETVREKVLKFIRDKLFP 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94158994   162 LPDEVL--TKEVEELILTESKKVLEDVTGEEFVLFMKILSGLKS---LQTVSGRQQLVELVAEQADLEQAFSPSDPDCVD 236
Cdd:pfam05918 161 LKEELLkpTEEMERHITDLIKKSLQDVTGDEFKMFMDFLKSLKIfgeKAPIEGMQELVEIIEEQADLDAQFNVSDTDHID 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94158994   237 RLLQCTRQAVPLFSKNVHSTRFVTYFCEQVLPNLSTLttpveGLDIQLEVLKLLAEMSSFCGDMEkLETNLRKLFDKLLE 316
Cdd:pfam05918 241 RLISCLRMALPFFSRGASSSKFVNYLCKKILPVFDKL-----PEERKLDLLKLLAEISPYTGPQD-ARELLPSVVQLLKE 314
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94158994   317 YMPLPPEeaengenagnEEPKLQFSYVECLLYSFHQLGRKLPDFLTA----------------KLNAEKLKDFKIRLQYF 380
Cdd:pfam05918 315 YMPLPKE----------TEPELNFTYVECLLYAFHHLAHKSPNFLNSlcgykivtgqpsdrlgEDFSEKLKDFTERLQYL 384
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94158994   381 ARGLQVYIRQLRLALQGKTGEALKTEENKIKVVALKITNNINVLIKDLFHIPPSY-KSTVTLSWKPVQK-------VEIG 452
Cdd:pfam05918 385 ARGTQATIKKLTQAMAGKTMAAAKTEENKIKITALKTTNNILTLIKDLFHKPPSFgKSNVNLSWKEAKKpsaasttTAAG 464
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....
gi 94158994   453 QKRTSE---DTSSGSPPKKspGGPKRDARQIYNPPSGKYSSNLSNFNYERSLQG 503
Cdd:pfam05918 465 GKRPAPitfGGASGNGAKK--GRGQGGQRQQYVPPSGKLSNKANEISHGGRGSG 516
 
Name Accession Description Interval E-value
API5 pfam05918
Apoptosis inhibitory protein 5 (API5); This family consists of apoptosis inhibitory protein 5 ...
4-503 0e+00

Apoptosis inhibitory protein 5 (API5); This family consists of apoptosis inhibitory protein 5 (API5) sequences from several organizms. Apoptosis or programmed cell death is a physiological form of cell death that occurs in embryonic development and organ formation. It is characterized by biochemical and morphological changes such as DNA fragmentation and cell volume shrinkage. API5 is an anti apoptosis gene located in human chromosome 11, whose expression prevents the programmed cell death that occurs upon the deprivation of growth factors and is up-regulated in various cancer cells. This protein has an elongated all alpha-helical structure, in which the N-terminal half is similar to the HEAT repeat and the C-terminal half is similar to the ARM (Armadillo-like) repeat. This suggests that API5 is involved in protein-protein interactions and may act as a scaffold for multiprotein complexes.


Pssm-ID: 428672 [Multi-domain]  Cd Length: 532  Bit Score: 656.38  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94158994     4 VEELYRNYGILADATEQVGQHKDAYQVILDGVKGGTKEKRLAAQFIPKFFKHFPELADSAINAQLDLCEDEDVSIRRQAI 83
Cdd:pfam05918   1 IEKLYENYEILNDAKDKISEHEEDYLGILDAVKGSAKEKQLASQFIPKFFKFFPSLANTAIDAQLDLCEDDDLGVRVQAI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94158994    84 KELPQFATG--ENLPRVADILTQLLQTDDSAEFNLVNNALLSIFKMDAKGTLGGLFSQILQGEDIVRERAIKFLSTKLKT 161
Cdd:pfam05918  81 KGLPLLCKDnpEYVPKIVDILGQLLNTEDPVERDAVHKALMSLLKQDTKASLTGLFKQIETGDETVREKVLKFIRDKLFP 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94158994   162 LPDEVL--TKEVEELILTESKKVLEDVTGEEFVLFMKILSGLKS---LQTVSGRQQLVELVAEQADLEQAFSPSDPDCVD 236
Cdd:pfam05918 161 LKEELLkpTEEMERHITDLIKKSLQDVTGDEFKMFMDFLKSLKIfgeKAPIEGMQELVEIIEEQADLDAQFNVSDTDHID 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94158994   237 RLLQCTRQAVPLFSKNVHSTRFVTYFCEQVLPNLSTLttpveGLDIQLEVLKLLAEMSSFCGDMEkLETNLRKLFDKLLE 316
Cdd:pfam05918 241 RLISCLRMALPFFSRGASSSKFVNYLCKKILPVFDKL-----PEERKLDLLKLLAEISPYTGPQD-ARELLPSVVQLLKE 314
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94158994   317 YMPLPPEeaengenagnEEPKLQFSYVECLLYSFHQLGRKLPDFLTA----------------KLNAEKLKDFKIRLQYF 380
Cdd:pfam05918 315 YMPLPKE----------TEPELNFTYVECLLYAFHHLAHKSPNFLNSlcgykivtgqpsdrlgEDFSEKLKDFTERLQYL 384
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94158994   381 ARGLQVYIRQLRLALQGKTGEALKTEENKIKVVALKITNNINVLIKDLFHIPPSY-KSTVTLSWKPVQK-------VEIG 452
Cdd:pfam05918 385 ARGTQATIKKLTQAMAGKTMAAAKTEENKIKITALKTTNNILTLIKDLFHKPPSFgKSNVNLSWKEAKKpsaasttTAAG 464
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....
gi 94158994   453 QKRTSE---DTSSGSPPKKspGGPKRDARQIYNPPSGKYSSNLSNFNYERSLQG 503
Cdd:pfam05918 465 GKRPAPitfGGASGNGAKK--GRGQGGQRQQYVPPSGKLSNKANEISHGGRGSG 516
 
Name Accession Description Interval E-value
API5 pfam05918
Apoptosis inhibitory protein 5 (API5); This family consists of apoptosis inhibitory protein 5 ...
4-503 0e+00

Apoptosis inhibitory protein 5 (API5); This family consists of apoptosis inhibitory protein 5 (API5) sequences from several organizms. Apoptosis or programmed cell death is a physiological form of cell death that occurs in embryonic development and organ formation. It is characterized by biochemical and morphological changes such as DNA fragmentation and cell volume shrinkage. API5 is an anti apoptosis gene located in human chromosome 11, whose expression prevents the programmed cell death that occurs upon the deprivation of growth factors and is up-regulated in various cancer cells. This protein has an elongated all alpha-helical structure, in which the N-terminal half is similar to the HEAT repeat and the C-terminal half is similar to the ARM (Armadillo-like) repeat. This suggests that API5 is involved in protein-protein interactions and may act as a scaffold for multiprotein complexes.


Pssm-ID: 428672 [Multi-domain]  Cd Length: 532  Bit Score: 656.38  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94158994     4 VEELYRNYGILADATEQVGQHKDAYQVILDGVKGGTKEKRLAAQFIPKFFKHFPELADSAINAQLDLCEDEDVSIRRQAI 83
Cdd:pfam05918   1 IEKLYENYEILNDAKDKISEHEEDYLGILDAVKGSAKEKQLASQFIPKFFKFFPSLANTAIDAQLDLCEDDDLGVRVQAI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94158994    84 KELPQFATG--ENLPRVADILTQLLQTDDSAEFNLVNNALLSIFKMDAKGTLGGLFSQILQGEDIVRERAIKFLSTKLKT 161
Cdd:pfam05918  81 KGLPLLCKDnpEYVPKIVDILGQLLNTEDPVERDAVHKALMSLLKQDTKASLTGLFKQIETGDETVREKVLKFIRDKLFP 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94158994   162 LPDEVL--TKEVEELILTESKKVLEDVTGEEFVLFMKILSGLKS---LQTVSGRQQLVELVAEQADLEQAFSPSDPDCVD 236
Cdd:pfam05918 161 LKEELLkpTEEMERHITDLIKKSLQDVTGDEFKMFMDFLKSLKIfgeKAPIEGMQELVEIIEEQADLDAQFNVSDTDHID 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94158994   237 RLLQCTRQAVPLFSKNVHSTRFVTYFCEQVLPNLSTLttpveGLDIQLEVLKLLAEMSSFCGDMEkLETNLRKLFDKLLE 316
Cdd:pfam05918 241 RLISCLRMALPFFSRGASSSKFVNYLCKKILPVFDKL-----PEERKLDLLKLLAEISPYTGPQD-ARELLPSVVQLLKE 314
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94158994   317 YMPLPPEeaengenagnEEPKLQFSYVECLLYSFHQLGRKLPDFLTA----------------KLNAEKLKDFKIRLQYF 380
Cdd:pfam05918 315 YMPLPKE----------TEPELNFTYVECLLYAFHHLAHKSPNFLNSlcgykivtgqpsdrlgEDFSEKLKDFTERLQYL 384
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94158994   381 ARGLQVYIRQLRLALQGKTGEALKTEENKIKVVALKITNNINVLIKDLFHIPPSY-KSTVTLSWKPVQK-------VEIG 452
Cdd:pfam05918 385 ARGTQATIKKLTQAMAGKTMAAAKTEENKIKITALKTTNNILTLIKDLFHKPPSFgKSNVNLSWKEAKKpsaasttTAAG 464
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....
gi 94158994   453 QKRTSE---DTSSGSPPKKspGGPKRDARQIYNPPSGKYSSNLSNFNYERSLQG 503
Cdd:pfam05918 465 GKRPAPitfGGASGNGAKK--GRGQGGQRQQYVPPSGKLSNKANEISHGGRGSG 516
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
62-113 7.74e-03

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 35.78  E-value: 7.74e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 94158994    62 SAINAQLDLCEDEDVSIRRQAIKELPQFATgenlPRVADILTQLLQTDDSAE 113
Cdd:pfam13646  31 EAVPALLELLKDEDPAVRRAAAEALGKIGD----PEALPALLELLRDDDDDV 78
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
70-153 9.89e-03

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 35.39  E-value: 9.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94158994    70 LCEDEDVSIRRQAIKELPQFATgenlPRVADILTQLLQTDDSaefNLVNNALLSIFKMDAKGTLGGLFSQILQGED-IVR 148
Cdd:pfam13646   8 LLRDPDPEVRAAAIRALGRIGD----PEAVPALLELLKDEDP---AVRRAAAEALGKIGDPEALPALLELLRDDDDdVVR 80

                  ....*
gi 94158994   149 ERAIK 153
Cdd:pfam13646  81 AAAAE 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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