NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|6680373|ref|NP_032364|]
View 

interferon gamma receptor 2 precursor [Mus musculus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Tissue_fac pfam01108
Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type ...
 14-121 3.26e-26

Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type III domain. The family is found in cytokine receptors, interleukin and interferon receptors and coagulation factor III proteins. It occurs multiple times, as does fn3, family pfam00041.


:

Pssm-ID: 460067  Cd Length: 107  Bit Score: 100.15  E-value: 3.26e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680373     14 CGLGAAASSPDSFSQLAAPLNPRLHLYNDEQILTWEPSPssNDPRPVVYQVEYS-FIDGSWHRLlePNCTDITETKCDLT 92
Cdd:pfam01108   7 GLLLLALASAAGGPSLPAPQNVTFQSTNFKNILTWEPGP--NSPPDVVYTVQYKiYGSGDWKNV--PNCTNITRTECDLT 82

                          90       100
                  ....*....|....*....|....*....
gi 6680373     93 GGGRlklfPHPFTVFLRVRAKRGNLTSKW 121
Cdd:pfam01108  83 DETS----DLTETYYARVRAVSGGGTSSW 107
Interfer-bind super family cl46366
Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary ...
 136-233 3.05e-09

Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha.


The actual alignment was detected with superfamily member pfam09294:

Pssm-ID: 480706  Cd Length: 103  Bit Score: 53.89  E-value: 3.05e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680373    136 GPPKnISVTPGKGSLVIHFSPPF----------DVFHGatFQYLVHYWEK-SETQQEQVEGPFksNSIVLGNLKPYRVYC 204
Cdd:pfam09294   4 GPPE-VELEVEGGSLNVTVKDPEtregknlslrDLYGS--LQYRVSYWKNsSNGEKKNTTSTN--SFVVLSDLEPGTTYC 78

                          90       100
                  ....*....|....*....|....*....
gi 6680373    205 LQTEAQLILKNKKIRPhgllSNVSCHETT 233
Cdd:pfam09294  79 VSVQAFSPLDNKSSQR----SPPQCIRTT 103
 
Name Accession Description Interval E-value
Tissue_fac pfam01108
Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type ...
 14-121 3.26e-26

Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type III domain. The family is found in cytokine receptors, interleukin and interferon receptors and coagulation factor III proteins. It occurs multiple times, as does fn3, family pfam00041.


Pssm-ID: 460067  Cd Length: 107  Bit Score: 100.15  E-value: 3.26e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680373     14 CGLGAAASSPDSFSQLAAPLNPRLHLYNDEQILTWEPSPssNDPRPVVYQVEYS-FIDGSWHRLlePNCTDITETKCDLT 92
Cdd:pfam01108   7 GLLLLALASAAGGPSLPAPQNVTFQSTNFKNILTWEPGP--NSPPDVVYTVQYKiYGSGDWKNV--PNCTNITRTECDLT 82

                          90       100
                  ....*....|....*....|....*....
gi 6680373     93 GGGRlklfPHPFTVFLRVRAKRGNLTSKW 121
Cdd:pfam01108  83 DETS----DLTETYYARVRAVSGGGTSSW 107
Interfer-bind pfam09294
Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary ...
 136-233 3.05e-09

Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha.


Pssm-ID: 462746  Cd Length: 103  Bit Score: 53.89  E-value: 3.05e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680373    136 GPPKnISVTPGKGSLVIHFSPPF----------DVFHGatFQYLVHYWEK-SETQQEQVEGPFksNSIVLGNLKPYRVYC 204
Cdd:pfam09294   4 GPPE-VELEVEGGSLNVTVKDPEtregknlslrDLYGS--LQYRVSYWKNsSNGEKKNTTSTN--SFVVLSDLEPGTTYC 78

                          90       100
                  ....*....|....*....|....*....
gi 6680373    205 LQTEAQLILKNKKIRPhgllSNVSCHETT 233
Cdd:pfam09294  79 VSVQAFSPLDNKSSQR----SPPQCIRTT 103
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 136-203 1.77e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 48.65  E-value: 1.77e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680373  136 GPPKNISVTP-GKGSLVIHFSPPFDvFHGATFQYLVHYWEKSETQQEQVE-GPFKSNSIVLGNLKPYRVY 203
Cdd:cd00063   2 SPPTNLRVTDvTSTSVTLSWTPPED-DGGPITGYVVEYREKGSGDWKEVEvTPGSETSYTLTGLKPGTEY 70
 
Name Accession Description Interval E-value
Tissue_fac pfam01108
Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type ...
 14-121 3.26e-26

Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type III domain. The family is found in cytokine receptors, interleukin and interferon receptors and coagulation factor III proteins. It occurs multiple times, as does fn3, family pfam00041.


Pssm-ID: 460067  Cd Length: 107  Bit Score: 100.15  E-value: 3.26e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680373     14 CGLGAAASSPDSFSQLAAPLNPRLHLYNDEQILTWEPSPssNDPRPVVYQVEYS-FIDGSWHRLlePNCTDITETKCDLT 92
Cdd:pfam01108   7 GLLLLALASAAGGPSLPAPQNVTFQSTNFKNILTWEPGP--NSPPDVVYTVQYKiYGSGDWKNV--PNCTNITRTECDLT 82

                          90       100
                  ....*....|....*....|....*....
gi 6680373     93 GGGRlklfPHPFTVFLRVRAKRGNLTSKW 121
Cdd:pfam01108  83 DETS----DLTETYYARVRAVSGGGTSSW 107
Interfer-bind pfam09294
Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary ...
 136-233 3.05e-09

Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha.


Pssm-ID: 462746  Cd Length: 103  Bit Score: 53.89  E-value: 3.05e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680373    136 GPPKnISVTPGKGSLVIHFSPPF----------DVFHGatFQYLVHYWEK-SETQQEQVEGPFksNSIVLGNLKPYRVYC 204
Cdd:pfam09294   4 GPPE-VELEVEGGSLNVTVKDPEtregknlslrDLYGS--LQYRVSYWKNsSNGEKKNTTSTN--SFVVLSDLEPGTTYC 78

                          90       100
                  ....*....|....*....|....*....
gi 6680373    205 LQTEAQLILKNKKIRPhgllSNVSCHETT 233
Cdd:pfam09294  79 VSVQAFSPLDNKSSQR----SPPQCIRTT 103
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 136-203 1.77e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 48.65  E-value: 1.77e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680373  136 GPPKNISVTP-GKGSLVIHFSPPFDvFHGATFQYLVHYWEKSETQQEQVE-GPFKSNSIVLGNLKPYRVY 203
Cdd:cd00063   2 SPPTNLRVTDvTSTSVTLSWTPPED-DGGPITGYVVEYREKGSGDWKEVEvTPGSETSYTLTGLKPGTEY 70
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH