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Conserved domains on  [gi|31982258|ref|NP_032366|]
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insulin-like growth factor-binding protein complex acid labile subunit isoform 1 precursor [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN00113 super family cl33413
leucine-rich repeat receptor-like protein kinase; Provisional
 61-523 4.38e-21

leucine-rich repeat receptor-like protein kinase; Provisional


The actual alignment was detected with superfamily member PLN00113:

Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 98.00  E-value: 4.38e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258   61 SSRNLT-QLPDSI---PVSTRALWLDGNNLS-SIPSAAFQNLSSLD---------------------FLNLQGSWLRSLE 114
Cdd:PLN00113 101 SNNQLSgPIPDDIfttSSSLRYLNLSNNNFTgSIPRGSIPNLETLDlsnnmlsgeipndigsfsslkVLDLGGNVLVGKI 180

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258  115 PQALLGLQNLYHLHLERNLLRSLAAGLFRHTPSLASLSLG-NNLLGRLEEGLfRGLSHLWDLNLGWNSLVVLPDTVFQGL 193
Cdd:PLN00113 181 PNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGyNNLSGEIPYEI-GGLTSLNHLDLVYNNLTGPIPSSLGNL 259

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258  194 GNLHELVLAGNKLTYLQPALLCGLGELRELDLSRNALRSVKANVFIHLPRLQKLYLDRNLITAVAPRAFLGMKALRWLDL 273
Cdd:PLN00113 260 KNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQL 339

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258  274 SHNRVAGlledTFPGLLGLH----VLRLAHNAITSLRPRTFKDLHFLEELQLGHNRIRQLGEKTFEGLGQLEVLTLNDNQ 349
Cdd:PLN00113 340 WSNKFSG----EIPKNLGKHnnltVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNS 415

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258  350 IHEVKVGAFFGLFNVAVMNLSGNCLrslpehvfqgLGRLHSLHLEHSCLGRIRLHTFAGLSGLRRLFlrdnsissieeqs 429
Cdd:PLN00113 416 FSGELPSEFTKLPLVYFLDISNNNL----------QGRINSRKWDMPSLQMLSLARNKFFGGLPDSF------------- 472

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258  430 laGLSELLELDLTANQLTHLPRQLFQGLGQLEYLLLSNNQLTMLSEDVLGPLQRAFWLDLSHNRLETPAEGLFSSLGRLR 509
Cdd:PLN00113 473 --GSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLS 550

                        490
                 ....*....|....
gi 31982258  510 YLNLRNNSLQTFVP 523
Cdd:PLN00113 551 QLDLSQNQLSGEIP 564
LRRNT smart00013
Leucine rich repeat N-terminal domain;
40-78 3.13e-06

Leucine rich repeat N-terminal domain;


:

Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 43.85  E-value: 3.13e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 31982258     40 QCPVTCTCSyddytdELSVFCSSRNLTQLPDSIPVSTRA 78
Cdd:smart00013   1 ACPAPCNCS------GTAVDCSGRGLTEVPLDLPPDTTL 33
LRRCT super family cl47026
Leucine rich repeat C-terminal domain;
535-578 1.68e-04

Leucine rich repeat C-terminal domain;


The actual alignment was detected with superfamily member smart00082:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 39.72  E-value: 1.68e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 31982258    535 NPWDCSCPLKALRDFaLQNPGVVPRFVQTVCEG-DDCQ-PVYTYNN 578
Cdd:smart00082   1 NPFICDCELRWLLRW-LQANEHLQDPVDLRCASpSSLRgPLLELLH 45
 
Name Accession Description Interval E-value
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 61-523 4.38e-21

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 98.00  E-value: 4.38e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258   61 SSRNLT-QLPDSI---PVSTRALWLDGNNLS-SIPSAAFQNLSSLD---------------------FLNLQGSWLRSLE 114
Cdd:PLN00113 101 SNNQLSgPIPDDIfttSSSLRYLNLSNNNFTgSIPRGSIPNLETLDlsnnmlsgeipndigsfsslkVLDLGGNVLVGKI 180

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258  115 PQALLGLQNLYHLHLERNLLRSLAAGLFRHTPSLASLSLG-NNLLGRLEEGLfRGLSHLWDLNLGWNSLVVLPDTVFQGL 193
Cdd:PLN00113 181 PNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGyNNLSGEIPYEI-GGLTSLNHLDLVYNNLTGPIPSSLGNL 259

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258  194 GNLHELVLAGNKLTYLQPALLCGLGELRELDLSRNALRSVKANVFIHLPRLQKLYLDRNLITAVAPRAFLGMKALRWLDL 273
Cdd:PLN00113 260 KNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQL 339

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258  274 SHNRVAGlledTFPGLLGLH----VLRLAHNAITSLRPRTFKDLHFLEELQLGHNRIRQLGEKTFEGLGQLEVLTLNDNQ 349
Cdd:PLN00113 340 WSNKFSG----EIPKNLGKHnnltVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNS 415

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258  350 IHEVKVGAFFGLFNVAVMNLSGNCLrslpehvfqgLGRLHSLHLEHSCLGRIRLHTFAGLSGLRRLFlrdnsissieeqs 429
Cdd:PLN00113 416 FSGELPSEFTKLPLVYFLDISNNNL----------QGRINSRKWDMPSLQMLSLARNKFFGGLPDSF------------- 472

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258  430 laGLSELLELDLTANQLTHLPRQLFQGLGQLEYLLLSNNQLTMLSEDVLGPLQRAFWLDLSHNRLETPAEGLFSSLGRLR 509
Cdd:PLN00113 473 --GSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLS 550

                        490
                 ....*....|....
gi 31982258  510 YLNLRNNSLQTFVP 523
Cdd:PLN00113 551 QLDLSQNQLSGEIP 564
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
53-422 4.72e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 95.77  E-value: 4.72e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258  53 TDELSVFCSSRNLTQLPDSIPVSTRALWLDGNNLSSIPSAAFQNLSSLDFLNLQGswlrslePQALLGLQNLYHLHLERN 132
Cdd:COG4886  51 LLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSG-------NEELSNLTNLESLDLSGN 123

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258 133 LLRSLAAGLFRHTpSLASLSLGNNLLGRLEEGLFrGLSHLWDLNLGWNSLVVLPDtVFQGLGNLHELVLAGNKLTYLqPA 212
Cdd:COG4886 124 QLTDLPEELANLT-NLKELDLSNNQLTDLPEPLG-NLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDL-PE 199

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258 213 LLCGLGELRELDLSRNALRSVKANvFIHLPRLQKLYLDRNLITAVAprAFLGMKALRWLDLSHNRVAGLleDTFPGLLGL 292
Cdd:COG4886 200 PLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDL--PPLANLTNL 274

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258 293 HVLRLAHNAITSLRPRTFKDLHFLEELQLGHNRIrqLGEKTFEGLGQLEVLTLNDNQIHEVKVGAFFGLFNVAVMNLSGN 372
Cdd:COG4886 275 KTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLL--NLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTL 352

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|
gi 31982258 373 CLRSLPEHVFQGLGRLHSLHLEHSCLGRIRLHTFAGLSGLRRLFLRDNSI 422
Cdd:COG4886 353 LLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLL 402
LRR_8 pfam13855
Leucine rich repeat;
219-278 9.42e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 60.23  E-value: 9.42e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258   219 ELRELDLSRNALRSVKANVFIHLPRLQKLYLDRNLITAVAPRAFLGMKALRWLDLSHNRV 278
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 79-256 1.08e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 61.73  E-value: 1.08e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258  79 LWLDGNNLSSIPS-AAFQNLSSLDflnLQGSWLRSLEpqALLGLQNLYHLHLERNLLRSLaAGLfRHTPSLASLSLGNNL 157
Cdd:cd21340   7 LYLNDKNITKIDNlSLCKNLKVLY---LYDNKITKIE--NLEFLTNLTHLYLQNNQIEKI-ENL-ENLVNLKKLYLGGNR 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258 158 LGRLeEGLfRGLSHLWDLNLGW------NSLVVLPDTVFQGLGNLHELVLAGNKLTYLQPalLCGLGELRELDLSRNALR 231
Cdd:cd21340  80 ISVV-EGL-ENLTNLEELHIENqrlppgEKLTFDPRSLAALSNSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQIS 155

                       170       180
                ....*....|....*....|....*..
gi 31982258 232 SVK--ANVFIHLPRLQKLYLDRNLITA 256
Cdd:cd21340 156 DLEelLDLLSSWPSLRELDLTGNPVCK 182
LRRNT smart00013
Leucine rich repeat N-terminal domain;
40-78 3.13e-06

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 43.85  E-value: 3.13e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 31982258     40 QCPVTCTCSyddytdELSVFCSSRNLTQLPDSIPVSTRA 78
Cdd:smart00013   1 ACPAPCNCS------GTAVDCSGRGLTEVPLDLPPDTTL 33
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 40-73 1.03e-05

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 42.23  E-value: 1.03e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 31982258    40 QCPVTCTCSyddytdELSVFCSSRNLTQLPDSIP 73
Cdd:pfam01462   1 ACPVPCHCS------ATVVNCSDRGLTAVPRDLP 28
LRRCT smart00082
Leucine rich repeat C-terminal domain;
535-578 1.68e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 39.72  E-value: 1.68e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 31982258    535 NPWDCSCPLKALRDFaLQNPGVVPRFVQTVCEG-DDCQ-PVYTYNN 578
Cdd:smart00082   1 NPFICDCELRWLLRW-LQANEHLQDPVDLRCASpSSLRgPLLELLH 45
 
Name Accession Description Interval E-value
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 61-523 4.38e-21

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 98.00  E-value: 4.38e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258   61 SSRNLT-QLPDSI---PVSTRALWLDGNNLS-SIPSAAFQNLSSLD---------------------FLNLQGSWLRSLE 114
Cdd:PLN00113 101 SNNQLSgPIPDDIfttSSSLRYLNLSNNNFTgSIPRGSIPNLETLDlsnnmlsgeipndigsfsslkVLDLGGNVLVGKI 180

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258  115 PQALLGLQNLYHLHLERNLLRSLAAGLFRHTPSLASLSLG-NNLLGRLEEGLfRGLSHLWDLNLGWNSLVVLPDTVFQGL 193
Cdd:PLN00113 181 PNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGyNNLSGEIPYEI-GGLTSLNHLDLVYNNLTGPIPSSLGNL 259

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258  194 GNLHELVLAGNKLTYLQPALLCGLGELRELDLSRNALRSVKANVFIHLPRLQKLYLDRNLITAVAPRAFLGMKALRWLDL 273
Cdd:PLN00113 260 KNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQL 339

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258  274 SHNRVAGlledTFPGLLGLH----VLRLAHNAITSLRPRTFKDLHFLEELQLGHNRIRQLGEKTFEGLGQLEVLTLNDNQ 349
Cdd:PLN00113 340 WSNKFSG----EIPKNLGKHnnltVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNS 415

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258  350 IHEVKVGAFFGLFNVAVMNLSGNCLrslpehvfqgLGRLHSLHLEHSCLGRIRLHTFAGLSGLRRLFlrdnsissieeqs 429
Cdd:PLN00113 416 FSGELPSEFTKLPLVYFLDISNNNL----------QGRINSRKWDMPSLQMLSLARNKFFGGLPDSF------------- 472

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258  430 laGLSELLELDLTANQLTHLPRQLFQGLGQLEYLLLSNNQLTMLSEDVLGPLQRAFWLDLSHNRLETPAEGLFSSLGRLR 509
Cdd:PLN00113 473 --GSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLS 550

                        490
                 ....*....|....
gi 31982258  510 YLNLRNNSLQTFVP 523
Cdd:PLN00113 551 QLDLSQNQLSGEIP 564
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
53-422 4.72e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 95.77  E-value: 4.72e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258  53 TDELSVFCSSRNLTQLPDSIPVSTRALWLDGNNLSSIPSAAFQNLSSLDFLNLQGswlrslePQALLGLQNLYHLHLERN 132
Cdd:COG4886  51 LLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSG-------NEELSNLTNLESLDLSGN 123

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258 133 LLRSLAAGLFRHTpSLASLSLGNNLLGRLEEGLFrGLSHLWDLNLGWNSLVVLPDtVFQGLGNLHELVLAGNKLTYLqPA 212
Cdd:COG4886 124 QLTDLPEELANLT-NLKELDLSNNQLTDLPEPLG-NLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDL-PE 199

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258 213 LLCGLGELRELDLSRNALRSVKANvFIHLPRLQKLYLDRNLITAVAprAFLGMKALRWLDLSHNRVAGLleDTFPGLLGL 292
Cdd:COG4886 200 PLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDL--PPLANLTNL 274

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258 293 HVLRLAHNAITSLRPRTFKDLHFLEELQLGHNRIrqLGEKTFEGLGQLEVLTLNDNQIHEVKVGAFFGLFNVAVMNLSGN 372
Cdd:COG4886 275 KTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLL--NLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTL 352

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|
gi 31982258 373 CLRSLPEHVFQGLGRLHSLHLEHSCLGRIRLHTFAGLSGLRRLFLRDNSI 422
Cdd:COG4886 353 LLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLL 402
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
148-557 5.46e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 95.77  E-value: 5.46e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258 148 LASLSLGNNLLGRLEEGLFRGLSHLWDLNLGWNSLVVLPDTVFQGLGNLHELVLAGNKLTYLQPALLcGLGELRELDLSR 227
Cdd:COG4886   3 LLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLL-SLLLLLLLSLLL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258 228 NALRSVKANVFIHLPRLQKLYLDRNlitavapRAFLGMKALRWLDLSHNRVAGLlEDTFPGLLGLHVLRLAHNAITSLrP 307
Cdd:COG4886  82 LSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDL-P 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258 308 RTFKDLHFLEELQLGHNRIRQLGEkTFEGLGQLEVLTLNDNQIHEVKVgAFFGLFNVAVMNLSGNCLRSLPEhVFQGLGR 387
Cdd:COG4886 153 EPLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDLPE-PLANLTN 229

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258 388 LHSLHLEHSCLGRIRlhTFAGLSGLRRLFLRDNSISSIEEqsLAGLSELLELDLTANQLTHLPRQ---LFQGLGQLEYLL 464
Cdd:COG4886 230 LETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDLKLKeleLLLGLNSLLLLL 305

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258 465 LSNNQLTMLSEDVLGPLQRAFWLDLSHNRLETPAEGLFSSLGRLRYLNLRNNSLQTFVPQPGLERLWLDANPWDCSCPLK 544
Cdd:COG4886 306 LLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALL 385

                       410
                ....*....|...
gi 31982258 545 ALRDFALQNPGVV 557
Cdd:COG4886 386 LLTLLLLLLTTTA 398
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
147-521 5.93e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 95.77  E-value: 5.93e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258 147 SLASLSLGNNLLGRLEEGLFRGLSHLWDLNLGWNSLVVLPDTVFQGLGNLHELVLAGNKLtylqpalLCGLGELRELDLS 226
Cdd:COG4886  49 LTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEE-------LSNLTNLESLDLS 121

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258 227 RNALRSVKANVFiHLPRLQKLYLDRNLITAVaPRAFLGMKALRWLDLSHNRVAGlLEDTFPGLLGLHVLRLAHNAITSLr 306
Cdd:COG4886 122 GNQLTDLPEELA-NLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTD-LPEELGNLTNLKELDLSNNQITDL- 197

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258 307 PRTFKDLHFLEELQLGHNRIRQLGEkTFEGLGQLEVLTLNDNQIHEVKvgAFFGLFNVAVMNLSGNCLRSLPEhvFQGLG 386
Cdd:COG4886 198 PEPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPP--LANLT 272

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258 387 RLHSLHLEHSCLGRIRLHTFAGLSGLRRLFLRDNSISSIEEQSLagLSELLELDLTANQLTHLPRQLFQGLGQLEYLLLS 466
Cdd:COG4886 273 NLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLIL--LLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALL 350

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....*
gi 31982258 467 NNQLTMLSEDVLGPLQRAFWLDLSHNRLETPAEGLFSSLGRLRYLNLRNNSLQTF 521
Cdd:COG4886 351 TLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTL 405
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 131-519 7.11e-15

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 78.35  E-value: 7.11e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258  131 RNLLRSLAAGLFrHTPSLASLSLGNNLL-GRLEEGLFRGLSHLWDLNLGWNSLVvlpDTVFQG-LGNLHELVLAGNKLTY 208
Cdd:PLN00113  79 KNISGKISSAIF-RLPYIQTINLSNNQLsGPIPDDIFTTSSSLRYLNLSNNNFT---GSIPRGsIPNLETLDLSNNMLSG 154

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258  209 LQPALLCGLGELRELDLSRNALRSVKANVFIHLPRLQKLYLDRNLITAVAPRAFLGMKALRWLDLSHNRVAGLLEDTFPG 288
Cdd:PLN00113 155 EIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEIPYEIGG 234

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258  289 LLGLHVLRLAHNAITSLRPRTFKDLHFLEELQLGHNRIRQLGEKTFEGLGQLEVLTLNDNqihevkvgaffglfnvavmN 368
Cdd:PLN00113 235 LTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDN-------------------S 295

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258  369 LSGnclrSLPEHVFQgLGRLHSLHL-EHSCLGRIRLhTFAGLSGLRRLFLRDNSISSIEEQSLAGLSELLELDLTANQLT 447
Cdd:PLN00113 296 LSG----EIPELVIQ-LQNLEILHLfSNNFTGKIPV-ALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLT 369

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 31982258  448 -HLPRQLFQGlGQLEYLLLSNNQLTMLSEDVLGPLQRAFWLDLSHNRLETPAEGLFSSLGRLRYLNLRNNSLQ 519
Cdd:PLN00113 370 gEIPEGLCSS-GNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQ 441
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 68-372 3.34e-13

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 72.96  E-value: 3.34e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258   68 LPDSIPVS------TRALWLDGNNLS-SIPSAAF--QNLSSLDFLNlqgSWLRSLEPQALLGLQNLYHLHLERNLLRSLA 138
Cdd:PLN00113 248 LTGPIPSSlgnlknLQYLFLYQNKLSgPIPPSIFslQKLISLDLSD---NSLSGEIPELVIQLQNLEILHLFSNNFTGKI 324

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258  139 AGLFRHTPSLASLSL-GNNLLGRLEEGLFRGlSHLWDLNLGWNSLV-VLPDTVFQGlGNLHELVLAGNKLTYLQPALLCG 216
Cdd:PLN00113 325 PVALTSLPRLQVLQLwSNKFSGEIPKNLGKH-NNLTVLDLSTNNLTgEIPEGLCSS-GNLFKLILFSNSLEGEIPKSLGA 402

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258  217 LGELRELDLSRNALRSVKANVFIHLP-----------------------------------------------RLQKLYL 249
Cdd:PLN00113 403 CRSLRRVRLQDNSFSGELPSEFTKLPlvyfldisnnnlqgrinsrkwdmpslqmlslarnkffgglpdsfgskRLENLDL 482

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258  250 DRNLITAVAPRAFLGMKALRWLDLSHNRVAGLLEDTFPGLLGLHVLRLAHNAITSLRPRTFKDLHFLEELQLGHNrirQL 329
Cdd:PLN00113 483 SRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQN---QL 559

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 31982258  330 GEKTFEGLGQLEVL---TLNDNQIHEV--KVGAFFGLFNVAVmnlSGN 372
Cdd:PLN00113 560 SGEIPKNLGNVESLvqvNISHNHLHGSlpSTGAFLAINASAV---AGN 604
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
65-316 1.51e-12

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 70.50  E-value: 1.51e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258   65 LTQLPDSIPVSTRALWLDGNNLSSIPSAAFQNLSSldfLNLQGSWLRSLePQALlgLQNLYHLHLERNLLRSLAaglfRH 144
Cdd:PRK15370 190 LTTIPACIPEQITTLILDNNELKSLPENLQGNIKT---LYANSNQLTSI-PATL--PDTIQEMELSINRITELP----ER 259

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258  145 TPS-LASLSLGNNLLGRLEEGLFRGL------------------SHLWDLNLGWNSLVVLPDTVFQGLgnlhELVLAG-N 204
Cdd:PRK15370 260 LPSaLQSLDLFHNKISCLPENLPEELrylsvydnsirtlpahlpSGITHLNVQSNSLTALPETLPPGL----KTLEAGeN 335

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258  205 KLTYLQPALlcgLGELRELDLSRNALRSVKANVfihLPRLQKLYLDRNLITAVaPRAFLGmkALRWLDLSHNRVAGLLEd 284
Cdd:PRK15370 336 ALTSLPASL---PPELQVLDVSKNQITVLPETL---PPTITTLDVSRNALTNL-PENLPA--ALQIMQASRNNLVRLPE- 405

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 31982258  285 TFPGLLG-----LHVLrLAHNAITSlrpRTFKDLHFL 316
Cdd:PRK15370 406 SLPHFRGegpqpTRII-VEYNPFSE---RTIQNMQRL 438
LRR_8 pfam13855
Leucine rich repeat;
219-278 9.42e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 60.23  E-value: 9.42e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258   219 ELRELDLSRNALRSVKANVFIHLPRLQKLYLDRNLITAVAPRAFLGMKALRWLDLSHNRV 278
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
410-470 9.36e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.53  E-value: 9.36e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 31982258   410 SGLRRLFLRDNSISSIEEQSLAGLSELLELDLTANQLTHLPRQLFQGLGQLEYLLLSNNQL 470
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 79-256 1.08e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 61.73  E-value: 1.08e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258  79 LWLDGNNLSSIPS-AAFQNLSSLDflnLQGSWLRSLEpqALLGLQNLYHLHLERNLLRSLaAGLfRHTPSLASLSLGNNL 157
Cdd:cd21340   7 LYLNDKNITKIDNlSLCKNLKVLY---LYDNKITKIE--NLEFLTNLTHLYLQNNQIEKI-ENL-ENLVNLKKLYLGGNR 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258 158 LGRLeEGLfRGLSHLWDLNLGW------NSLVVLPDTVFQGLGNLHELVLAGNKLTYLQPalLCGLGELRELDLSRNALR 231
Cdd:cd21340  80 ISVV-EGL-ENLTNLEELHIENqrlppgEKLTFDPRSLAALSNSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQIS 155

                       170       180
                ....*....|....*....|....*..
gi 31982258 232 SVK--ANVFIHLPRLQKLYLDRNLITA 256
Cdd:cd21340 156 DLEelLDLLSSWPSLRELDLTGNPVCK 182
LRR_8 pfam13855
Leucine rich repeat;
291-350 1.40e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.15  E-value: 1.40e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258   291 GLHVLRLAHNAITSLRPRTFKDLHFLEELQLGHNRIRQLGEKTFEGLGQLEVLTLNDNQI 350
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 223-524 1.57e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 64.10  E-value: 1.57e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258  223 LDLSRNALRSVKANVFIHLPRLQKLYLDRNLITAVAPRA-FLGMKALRWLDLSHNRVAGLLEDTFpgLLGLHVLRLAHNA 301
Cdd:PLN00113  74 IDLSGKNISGKISSAIFRLPYIQTINLSNNQLSGPIPDDiFTTSSSLRYLNLSNNNFTGSIPRGS--IPNLETLDLSNNM 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258  302 ITSLRPRTFKDLHFLEELQLGHNRIRQLGEKTFEGLGQLEVLTLNDNQI-----HEVKVGAFFGLFNVAVMNLSGnclrS 376
Cdd:PLN00113 152 LSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLvgqipRELGQMKSLKWIYLGYNNLSG----E 227

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258  377 LPEHvfqgLGRLHSL-HLE---HSCLGRIRlHTFAGLSGLRRLFLRDNSISSIEEQSLAGLSELLELDLTANQLTHLPRQ 452
Cdd:PLN00113 228 IPYE----IGGLTSLnHLDlvyNNLTGPIP-SSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPE 302

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 31982258  453 LFQGLGQLEYLLLSNNQLTmlsedvlGPLQRAFwldlshnrletpaeglfSSLGRLRYLNLRNNSLQTFVPQ 524
Cdd:PLN00113 303 LVIQLQNLEILHLFSNNFT-------GKIPVAL-----------------TSLPRLQVLQLWSNKFSGEIPK 350
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 195-348 1.76e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 58.26  E-value: 1.76e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258 195 NLHELVLAGNKLTYLQPalLCGLGELRELDLSRNALRsvKANVFIHLPRLQKLYLDRNLITAVAprAFLGMKALRWLDLS 274
Cdd:cd21340  25 NLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIE--KIENLENLVNLKKLYLGGNRISVVE--GLENLTNLEELHIE 98

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258 275 HNRVA---GLLED--TFPGLLG-LHVLRLAHNAITSLRPrtFKDLHFLEELQLGHNRIRQLGE--KTFEGLGQLEVLTLN 346
Cdd:cd21340  99 NQRLPpgeKLTFDprSLAALSNsLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLT 176


                ..
gi 31982258 347 DN 348
Cdd:cd21340 177 GN 178
LRR_8 pfam13855
Leucine rich repeat;
387-446 1.78e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.07  E-value: 1.78e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258   387 RLHSLHLEHSCLGRIRLHTFAGLSGLRRLFLRDNSISSIEEQSLAGLSELLELDLTANQL 446
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
319-536 2.29e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 60.48  E-value: 2.29e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258  319 LQLGHNRIRQLGEKTFeglGQLEVLTLNDNQIHEVKVGAffgLFNVAVMNLSGNCLRSLPEHVFQGLGRLHSLHLEHSCL 398
Cdd:PRK15370 204 LILDNNELKSLPENLQ---GNIKTLYANSNQLTSIPATL---PDTIQEMELSINRITELPERLPSALQSLDLFHNKISCL 277

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258  399 GrirlHTFAglSGLRRLFLRDNSISSIEEQSLAGLSellELDLTANQLTHLPRQLFQGLG------------------QL 460
Cdd:PRK15370 278 P----ENLP--EELRYLSVYDNSIRTLPAHLPSGIT---HLNVQSNSLTALPETLPPGLKtleagenaltslpaslppEL 348

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258  461 EYLLLSNNQLTMLSEDVLGPLQRafwLDLSHNRLETPAEGLFSSlgrLRYLNL-RNN------SLQTFV---PQPGleRL 530
Cdd:PRK15370 349 QVLDVSKNQITVLPETLPPTITT---LDVSRNALTNLPENLPAA---LQIMQAsRNNlvrlpeSLPHFRgegPQPT--RI 420


                 ....*.
gi 31982258  531 WLDANP 536
Cdd:PRK15370 421 IVEYNP 426
LRR_8 pfam13855
Leucine rich repeat;
122-182 2.58e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.30  E-value: 2.58e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 31982258   122 QNLYHLHLERNLLRSLAAGLFRHTPSLASLSLGNNLLGRLEEGLFRGLSHLWDLNLGWNSL 182
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 337-519 2.89e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 57.49  E-value: 2.89e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258 337 LGQLEVLTLNDNQIheVKVGAFFGLFNVAVMNLSGNCLRSLPEhvFQGLGRLHSLHLEHSCLGRIRlhTFAGLSGLRRLF 416
Cdd:cd21340   1 LKRITHLYLNDKNI--TKIDNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIE--NLENLVNLKKLY 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258 417 LRDNSISSIEeqSLAGLSELLELDLtANQlthlprQLFQGlgqlEYLLLSNNQLTMLSEDvlgpLQRafwLDLSHNRLET 496
Cdd:cd21340  75 LGGNRISVVE--GLENLTNLEELHI-ENQ------RLPPG----EKLTFDPRSLAALSNS----LRV---LNISGNNIDS 134

                       170       180
                ....*....|....*....|...
gi 31982258 497 PAEglFSSLGRLRYLNLRNNSLQ 519
Cdd:cd21340 135 LEP--LAPLRNLEQLDASNNQIS 155
LRR_8 pfam13855
Leucine rich repeat;
242-326 3.74e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.91  E-value: 3.74e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258   242 PRLQKLYLDRNLITAVAPRAFLGMKALRWLDLSHNRvaglledtfpgllglhvlrlahnaITSLRPRTFKDLHFLEELQL 321
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNL------------------------LTTLSPGAFSGLPSLRYLDL 56


                  ....*
gi 31982258   322 GHNRI 326
Cdd:pfam13855  57 SGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
195-254 5.64e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.53  E-value: 5.64e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258   195 NLHELVLAGNKLTYLQPALLCGLGELRELDLSRNALRSVKANVFIHLPRLQKLYLDRNLI 254
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
434-494 7.64e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.14  E-value: 7.64e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 31982258   434 SELLELDLTANQLTHLPRQLFQGLGQLEYLLLSNNQLTMLSEDVLGPLQRAFWLDLSHNRL 494
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
146-206 1.83e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.99  E-value: 1.83e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 31982258   146 PSLASLSLGNNLLGRLEEGLFRGLSHLWDLNLGWNSLVVLPDTVFQGLGNLHELVLAGNKL 206
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
339-395 2.89e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.60  E-value: 2.89e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 31982258   339 QLEVLTLNDNQIHEVKVGAFFGLFNVAVMNLSGNCLRSLPEHVFQGLGRLHSLHLEH 395
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSG 58
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 277-537 4.34e-08

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 55.05  E-value: 4.34e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258 277 RVAGLLEDTFPGLLGLHVLRLAHNAITSLRPRTFKDLH---FLEELQLGHNRIRQLGEKTF-EGLGQ----LEVLTLNDN 348
Cdd:cd00116  68 RGLQSLLQGLTKGCGLQELDLSDNALGPDGCGVLESLLrssSLQELKLNNNGLGDRGLRLLaKGLKDlppaLEKLVLGRN 147

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258 349 qihevkvgaffglfnvavmNLSGNCLRSLPEhVFQGLGRLHSLHLEHSCLG----RIRLHTFAGLSGLRRLFLRDNSISS 424
Cdd:cd00116 148 -------------------RLEGASCEALAK-ALRANRDLKELNLANNGIGdagiRALAEGLKANCNLEVLDLNNNGLTD 207

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258 425 IEEQSLAG----LSELLELDLTANQLT-----HLPRQLFQGLGQLEYLLLSNNQLTMLS-EDVLGPL---QRAFWLDLSH 491
Cdd:cd00116 208 EGASALAEtlasLKSLEVLNLGDNNLTdagaaALASALLSPNISLLTLSLSCNDITDDGaKDLAEVLaekESLLELDLRG 287

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 31982258 492 NRLETPAEGLFSSLGRlrylnlrnnslqtfVPQPGLERLWLDANPW 537
Cdd:cd00116 288 NKFGEEGAQLLAESLL--------------EPGNELESLWVKDDSF 319
LRR_8 pfam13855
Leucine rich repeat;
170-230 1.26e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.67  E-value: 1.26e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 31982258   170 SHLWDLNLGWNSLVVLPDTVFQGLGNLHELVLAGNKLTYLQPALLCGLGELRELDLSRNAL 230
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 385-534 7.35e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.17  E-value: 7.35e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258 385 LGRLHSLHLEHSCLGRIrlHTFAGLSGLRRLFLRDNSISSIEeqSLAGLSELLELDLTANQLTHLPRqlFQGLGQLEYLL 464
Cdd:cd21340   1 LKRITHLYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLY 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258 465 LSNNQ---------LTMLSEdvlgplqrafwLDLSHNRLETPAEGLF------SSLGRLRYLNLRNNSLQTFVPQPGLER 529
Cdd:cd21340  75 LGGNRisvveglenLTNLEE-----------LHIENQRLPPGEKLTFdprslaALSNSLRVLNISGNNIDSLEPLAPLRN 143


                ....*.
gi 31982258 530 L-WLDA 534
Cdd:cd21340 144 LeQLDA 149
LRR_8 pfam13855
Leucine rich repeat;
316-372 1.14e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.98  E-value: 1.14e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 31982258   316 LEELQLGHNRIRQLGEKTFEGLGQLEVLTLNDNQIHEVKVGAFFGLFNVAVMNLSGN 372
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
LRR_8 pfam13855
Leucine rich repeat;
363-422 1.30e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.59  E-value: 1.30e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258   363 NVAVMNLSGNCLRSLPEHVFQGLGRLHSLHLEHSCLGRIRLHTFAGLSGLRRLFLRDNSI 422
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 292-451 1.98e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 49.01  E-value: 1.98e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258 292 LHVLRLAHNAITSLRPRTFkdLHFLEELQLGHNRIRQLGEktFEGLGQLEVLTLNDNQIHEVKvgaffGLFNVavMNL-- 369
Cdd:cd21340  26 LKVLYLYDNKITKIENLEF--LTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVVE-----GLENL--TNLee 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258 370 ---------SGNCLRSLPEHVFQGLGRLHSLHLEHSCLGRIRlhTFAGLSGLRRLFLRDNSISSIEE--QSLAGLSELLE 438
Cdd:cd21340  95 lhienqrlpPGEKLTFDPRSLAALSNSLRVLNISGNNIDSLE--PLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRE 172

                       170
                ....*....|...
gi 31982258 439 LDLTANQLTHLPR 451
Cdd:cd21340 173 LDLTGNPVCKKPK 185
LRR_8 pfam13855
Leucine rich repeat;
81-134 2.87e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.82  E-value: 2.87e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 31982258    81 LDGNNLSSIPSAAFQNLSSLDFLNLQGSWLRSLEPQALLGLQNLYHLHLERNLL 134
Cdd:pfam13855   8 LSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRRNT smart00013
Leucine rich repeat N-terminal domain;
40-78 3.13e-06

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 43.85  E-value: 3.13e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 31982258     40 QCPVTCTCSyddytdELSVFCSSRNLTQLPDSIPVSTRA 78
Cdd:smart00013   1 ACPAPCNCS------GTAVDCSGRGLTEVPLDLPPDTTL 33
LRR_8 pfam13855
Leucine rich repeat;
98-158 5.54e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.05  E-value: 5.54e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 31982258    98 SSLDFLNLQGSWLRSLEPQALLGLQNLYHLHLERNLLRSLAAGLFRHTPSLASLSLGNNLL 158
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 40-73 1.03e-05

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 42.23  E-value: 1.03e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 31982258    40 QCPVTCTCSyddytdELSVFCSSRNLTQLPDSIP 73
Cdd:pfam01462   1 ACPVPCHCS------ATVVNCSDRGLTAVPRDLP 28
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
65-340 1.03e-05

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 48.62  E-value: 1.03e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258   65 LTQLPDSIPVSTRALWLDGNNLSSIPSAAfqnlSSLDFLNLQGSWLRSLePQALLGLQNLYHLHLERNLLRSLAAGLFR- 143
Cdd:PRK15387 213 LTTLPDCLPAHITTLVIPDNNLTSLPALP----PELRTLEVSGNQLTSL-PVLPPGLLELSIFSNPLTHLPALPSGLCKl 287

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258  144 ------------HTPSLASLSLGNNLLGRLeEGLFRGLSHLWDLNLGWNSLVVLPDtvfqglgNLHELVLAGNKLTYLqP 211
Cdd:PRK15387 288 wifgnqltslpvLPPGLQELSVSDNQLASL-PALPSELCKLWAYNNQLTSLPTLPS-------GLQELSVSDNQLASL-P 358

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258  212 ALlcgLGELRELDLSRNALRSVKAnvfihLPR-LQKLYLDRNLITA--VAPraflgmKALRWLDLSHNRVAGLleDTFP- 287
Cdd:PRK15387 359 TL---PSELYKLWAYNNRLTSLPA-----LPSgLKELIVSGNRLTSlpVLP------SELKELMVSGNRLTSL--PMLPs 422

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 31982258  288 GLLGLHVLRlahNAITSLrPRTFKDLHFLEELQLGHNrirQLGEKTFEGLGQL 340
Cdd:PRK15387 423 GLLSLSVYR---NQLTRL-PESLIHLSSETTVNLEGN---PLSERTLQALREI 468
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
223-477 1.32e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 48.15  E-value: 1.32e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258  223 LDLSRNALRSVKANVFIHLprlQKLYLDRNLITAVaPRAFlgMKALRWLDLSHNRVAGLLEDtFPGllGLHVLRLAHNAI 302
Cdd:PRK15370 204 LILDNNELKSLPENLQGNI---KTLYANSNQLTSI-PATL--PDTIQEMELSINRITELPER-LPS--ALQSLDLFHNKI 274

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258  303 TSLrPRTFKDlhFLEELQLGHNRIRQLGEKTFEGLGQLevltlndnqihevkvgaffglfnvavmNLSGNCLRSLPEHVF 382
Cdd:PRK15370 275 SCL-PENLPE--ELRYLSVYDNSIRTLPAHLPSGITHL---------------------------NVQSNSLTALPETLP 324

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258  383 QGLGRLHSLHLEHSCLGrirlhtfAGLS-GLRRLFLRDNSISSIEEQSLAGLSELlelDLTANQLTHLPRQLfqgLGQLE 461
Cdd:PRK15370 325 PGLKTLEAGENALTSLP-------ASLPpELQVLDVSKNQITVLPETLPPTITTL---DVSRNALTNLPENL---PAALQ 391

                        250
                 ....*....|....*.
gi 31982258  462 YLLLSNNQLTMLSEDV 477
Cdd:PRK15370 392 IMQASRNNLVRLPESL 407
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 143-350 2.24e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 46.58  E-value: 2.24e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258 143 RHTPSLASLSLGNNLLGRLEEGL------FRGLSHLWDLNLGWNSLVVLPDTVFQGL---GNLHELVLAGNKLTYLQPAL 213
Cdd:cd00116  48 RPQPSLKELCLSLNETGRIPRGLqsllqgLTKGCGLQELDLSDNALGPDGCGVLESLlrsSSLQELKLNNNGLGDRGLRL 127

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258 214 LC-GLGE----LRELDLSRNALRSVK----ANVFIHLPRLQKLYLDRNlitavapraflgmkalrwlDLSHNRVAGLLED 284
Cdd:cd00116 128 LAkGLKDlppaLEKLVLGRNRLEGAScealAKALRANRDLKELNLANN-------------------GIGDAGIRALAEG 188

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 31982258 285 tFPGLLGLHVLRLAHNAITSLRPR----TFKDLHFLEELQLGHNRIRQLGEKTF-----EGLGQLEVLTLNDNQI 350
Cdd:cd00116 189 -LKANCNLEVLDLNNNGLTDEGASalaeTLASLKSLEVLNLGDNNLTDAGAAALasallSPNISLLTLSLSCNDI 262
LRRCT smart00082
Leucine rich repeat C-terminal domain;
535-578 1.68e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 39.72  E-value: 1.68e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 31982258    535 NPWDCSCPLKALRDFaLQNPGVVPRFVQTVCEG-DDCQ-PVYTYNN 578
Cdd:smart00082   1 NPFICDCELRWLLRW-LQANEHLQDPVDLRCASpSSLRgPLLELLH 45
PLN03150 PLN03150
hypothetical protein; Provisional
 223-307 1.86e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 44.42  E-value: 1.86e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258  223 LDLSRNALRSVKANVFIHLPRLQKLYLDRNLITAVAPRAFLGMKALRWLDLSHNRVAGLLEDTFPGLLGLHVLRLAHNAI 302
Cdd:PLN03150 423 LGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSL 502


                 ....*
gi 31982258  303 TSLRP 307
Cdd:PLN03150 503 SGRVP 507
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 223-478 3.26e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 43.63  E-value: 3.26e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258 223 LDLSRNALRS----VKANVFIHLPRLQKLYLDRNLITAVAPRAFLGM----KALRWLDLSHNRVaglledtfpGLLGLHV 294
Cdd:COG5238 185 VYLGCNQIGDegieELAEALTQNTTVTTLWLKRNPIGDEGAEILAEAlkgnKSLTTLDLSNNQI---------GDEGVIA 255

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258 295 L--RLAHNaitslrprtfkdlHFLEELQLGHNRIRQLG----EKTFEGLGQLEVLTLNDNQIHEVKVGAFF-GLFN---V 364
Cdd:COG5238 256 LaeALKNN-------------TTVETLYLSGNQIGAEGaialAKALQGNTTLTSLDLSVNRIGDEGAIALAeGLQGnktL 322

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258 365 AVMNLSGN-----CLRSLPEHVfQGLGRLHSLHLEHSCLGRirlhtfAGLSGLrrlflrdnsissieEQSLAGLSELLEL 439
Cdd:COG5238 323 HTLNLAYNgigaqGAIALAKAL-QENTTLHSLDLSDNQIGD------EGAIAL--------------AKYLEGNTTLREL 381

                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 31982258 440 DLTANQLTHLPRQ-LFQGL--GQLEYLLLSNNQLTMLSEDVL 478
Cdd:COG5238 382 NLGKNNIGKQGAEaLIDALqtNRLHTLILDGNLIGAEAQQRL 423
LRR_8 pfam13855
Leucine rich repeat;
486-536 4.26e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.66  E-value: 4.26e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 31982258   486 WLDLSHNRLETPAEGLFSSLGRLRYLNLRNNSLQTFVPQ-----PGLERLWLDANP 536
Cdd:pfam13855   5 SLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGafsglPSLRYLDLSGNR 60
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 412-535 8.47e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 41.96  E-value: 8.47e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258 412 LRRLFLRDNSISSIEE------QSLAGLSELLELDLTANQLTHLPRQLFQGLGQ---LEYLLLSNNQL----TMLSEDVL 478
Cdd:cd00116  53 LKELCLSLNETGRIPRglqsllQGLTKGCGLQELDLSDNALGPDGCGVLESLLRsssLQELKLNNNGLgdrgLRLLAKGL 132

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 31982258 479 GPLQ-RAFWLDLSHNRLE----TPAEGLFSSLGRLRYLNLRNNSL---------QTFVPQPGLERLWLDAN 535
Cdd:cd00116 133 KDLPpALEKLVLGRNRLEgascEALAKALRANRDLKELNLANNGIgdagiralaEGLKANCNLEVLDLNNN 203
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
60-258 1.78e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 41.07  E-value: 1.78e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258  60 CSSRNLTQLPDSIPVST--RALWLDGNNLSSIPS-AAFQNLSSLDflnLQGSWLRSLEPqaLLGLQNLYHLHLERNLLRS 136
Cdd:COG4886 212 LSGNQLTDLPEPLANLTnlETLDLSNNQLTDLPElGNLTNLEELD---LSNNQLTDLPP--LANLTNLKTLDLSNNQLTD 286

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982258 137 LAagLFRHTPSLASLSLGNNLLGRLEEGLFRGLSHLWDLNLGWNSLVVLPDTVFQGLGNLHELVLAGNKLTYLQPALLCG 216
Cdd:COG4886 287 LK--LKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLT 364

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 31982258 217 LGELRELDLSRNALRSVKANVFIHLPRLQKLYLDRNLITAVA 258
Cdd:COG4886 365 LLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLA 406
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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