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interleukin-7 receptor subunit alpha isoform 1 precursor [Mus musculus]
List of domain hits
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Name | Accession | Description | Interval | E-value | |||
FN3_7 | pfam18447 | Fibronectin type III domain; This domain is found in Interleukin-7 receptor subunit alpha ... |
32-127 | 3.62e-53 | |||
Fibronectin type III domain; This domain is found in Interleukin-7 receptor subunit alpha (IL-7Ralpha), which together IL-7 form a complex crucial to several signalling cascades leading to the development and homeostasis of T and B cells. IL-7Ralpha carries a 219 residue ectodomain on the N-terminal region which is crucial for T and B-cell development. Mutations in the IL-7Ralpha ectodomain inhibits T and B cell development, resulting in patients with a form of severe combined immunodeficiency (SCID). The ectodomain folds into two fibronectin type III (FNIII) domains connected by a 310-helical linker. This entry comprises the first of the two FNIII domains, D1 while D2 domain is pfam00041. In the D1 domain of IL-7Ralpha, a disulfide bond (C22R-C37R) conserved among cytokine receptor class I (CRH I) family members bridges two beta strands. : Pssm-ID: 465772 Cd Length: 97 Bit Score: 173.32 E-value: 3.62e-53
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fn3 | pfam00041 | Fibronectin type III domain; |
131-219 | 1.25e-05 | |||
Fibronectin type III domain; : Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 43.56 E-value: 1.25e-05
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Name | Accession | Description | Interval | E-value | |||
FN3_7 | pfam18447 | Fibronectin type III domain; This domain is found in Interleukin-7 receptor subunit alpha ... |
32-127 | 3.62e-53 | |||
Fibronectin type III domain; This domain is found in Interleukin-7 receptor subunit alpha (IL-7Ralpha), which together IL-7 form a complex crucial to several signalling cascades leading to the development and homeostasis of T and B cells. IL-7Ralpha carries a 219 residue ectodomain on the N-terminal region which is crucial for T and B-cell development. Mutations in the IL-7Ralpha ectodomain inhibits T and B cell development, resulting in patients with a form of severe combined immunodeficiency (SCID). The ectodomain folds into two fibronectin type III (FNIII) domains connected by a 310-helical linker. This entry comprises the first of the two FNIII domains, D1 while D2 domain is pfam00041. In the D1 domain of IL-7Ralpha, a disulfide bond (C22R-C37R) conserved among cytokine receptor class I (CRH I) family members bridges two beta strands. Pssm-ID: 465772 Cd Length: 97 Bit Score: 173.32 E-value: 3.62e-53
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fn3 | pfam00041 | Fibronectin type III domain; |
131-219 | 1.25e-05 | |||
Fibronectin type III domain; Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 43.56 E-value: 1.25e-05
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FN3 | cd00063 | Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
130-229 | 6.98e-03 | |||
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases. Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 35.94 E-value: 6.98e-03
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Name | Accession | Description | Interval | E-value | |||
FN3_7 | pfam18447 | Fibronectin type III domain; This domain is found in Interleukin-7 receptor subunit alpha ... |
32-127 | 3.62e-53 | |||
Fibronectin type III domain; This domain is found in Interleukin-7 receptor subunit alpha (IL-7Ralpha), which together IL-7 form a complex crucial to several signalling cascades leading to the development and homeostasis of T and B cells. IL-7Ralpha carries a 219 residue ectodomain on the N-terminal region which is crucial for T and B-cell development. Mutations in the IL-7Ralpha ectodomain inhibits T and B cell development, resulting in patients with a form of severe combined immunodeficiency (SCID). The ectodomain folds into two fibronectin type III (FNIII) domains connected by a 310-helical linker. This entry comprises the first of the two FNIII domains, D1 while D2 domain is pfam00041. In the D1 domain of IL-7Ralpha, a disulfide bond (C22R-C37R) conserved among cytokine receptor class I (CRH I) family members bridges two beta strands. Pssm-ID: 465772 Cd Length: 97 Bit Score: 173.32 E-value: 3.62e-53
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fn3 | pfam00041 | Fibronectin type III domain; |
131-219 | 1.25e-05 | |||
Fibronectin type III domain; Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 43.56 E-value: 1.25e-05
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FN3 | cd00063 | Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
130-229 | 6.98e-03 | |||
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases. Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 35.94 E-value: 6.98e-03
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Blast search parameters | ||||
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