NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|304555605|ref|NP_032810|]
View 

immunoglobulin-binding protein 1 [Mus musculus]

Protein Classification

IGBP1/TAP42 family protein( domain architecture ID 10514489)

IGBP1/TAP42 family protein similar to human immunoglobulin-binding protein 1 (IGBP1) that is involved in regulation of the catalytic activity of the phosphatases PP2A, PP4 and PP6, and to Saccharomyces cerevisiae type 2A phosphatase-associated protein 42 (TAP42) that is involved in negative regulation of the TOR signaling pathway in response to the available nitrogen source type

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
TAP42 pfam04177
TAP42-like family; The TOR signalling pathway activates a cell-growth program in response to ...
 17-330 9.28e-98

TAP42-like family; The TOR signalling pathway activates a cell-growth program in response to nutrients. TIP41 (pfam04176) interacts with TAP42 and negatively regulates the TOR signaling pathway.


:

Pssm-ID: 461209  Cd Length: 305  Bit Score: 291.43  E-value: 9.28e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304555605   17 FETSKKLLEDVEvATEPTGSRTIQDKVSKGLELLEKAAGMLSQLDLFSRNEDLEEIASTDLKYLMVPALQGALTMKQVN- 95
Cdd:pfam04177   5 FDSALKLYEELE-NSTPTNSPEYQDKVKSAIALLELCTKLVSQLSLFSSNETLEDISTSDLKYLLVPYYLGELTQKLQTd 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304555605   96 PSKRLDHLQRAREHFVHFLTQCHCYHVAEFQLPQ--TKTNSAENNTASSSMAYPNLVAMASQRQAKIERYKQKKEVEHRL 173
Cdd:pfam04177  84 PEDRLEVLKRAREYYEDFLKRLEDYELLPKEDKKllESFSSENYSELPELFSTASTSDAAARREEKIARFKREKELEQKL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304555605  174 SALKSAVES--GQADDERVREYHLLHLRRWIAVSLEELESIDQEIKILKEKdspreetachsslpEKPPMKPFIL--TRN 249
Cdd:pfam04177 164 EELKKRVESrsGQEDEEVVRELYLTQLKLAILKAFQELESIEQELEILEMA--------------PGKPLRPFTIlsTRE 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304555605  250 KAQAKVFGTGYpSLATMTVSDWYEQHQKYGVLPDRGiaKPASADFQRAAQQQEDQEQKDEESEEkaLHRMREWDDWKDTH 329
Cdd:pfam04177 230 ELQAKVFGPGH-SLPTMTVDEYLEEERRRGGIIEGG--GEASAAEPEEEEEEDEEDDEEKADEE--TYKAREWDEFKDDN 304


                  .
gi 304555605  330 P 330
Cdd:pfam04177 305 P 305
 
Name Accession Description Interval E-value
TAP42 pfam04177
TAP42-like family; The TOR signalling pathway activates a cell-growth program in response to ...
 17-330 9.28e-98

TAP42-like family; The TOR signalling pathway activates a cell-growth program in response to nutrients. TIP41 (pfam04176) interacts with TAP42 and negatively regulates the TOR signaling pathway.


Pssm-ID: 461209  Cd Length: 305  Bit Score: 291.43  E-value: 9.28e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304555605   17 FETSKKLLEDVEvATEPTGSRTIQDKVSKGLELLEKAAGMLSQLDLFSRNEDLEEIASTDLKYLMVPALQGALTMKQVN- 95
Cdd:pfam04177   5 FDSALKLYEELE-NSTPTNSPEYQDKVKSAIALLELCTKLVSQLSLFSSNETLEDISTSDLKYLLVPYYLGELTQKLQTd 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304555605   96 PSKRLDHLQRAREHFVHFLTQCHCYHVAEFQLPQ--TKTNSAENNTASSSMAYPNLVAMASQRQAKIERYKQKKEVEHRL 173
Cdd:pfam04177  84 PEDRLEVLKRAREYYEDFLKRLEDYELLPKEDKKllESFSSENYSELPELFSTASTSDAAARREEKIARFKREKELEQKL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304555605  174 SALKSAVES--GQADDERVREYHLLHLRRWIAVSLEELESIDQEIKILKEKdspreetachsslpEKPPMKPFIL--TRN 249
Cdd:pfam04177 164 EELKKRVESrsGQEDEEVVRELYLTQLKLAILKAFQELESIEQELEILEMA--------------PGKPLRPFTIlsTRE 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304555605  250 KAQAKVFGTGYpSLATMTVSDWYEQHQKYGVLPDRGiaKPASADFQRAAQQQEDQEQKDEESEEkaLHRMREWDDWKDTH 329
Cdd:pfam04177 230 ELQAKVFGPGH-SLPTMTVDEYLEEERRRGGIIEGG--GEASAAEPEEEEEEDEEDDEEKADEE--TYKAREWDEFKDDN 304


                  .
gi 304555605  330 P 330
Cdd:pfam04177 305 P 305
 
Name Accession Description Interval E-value
TAP42 pfam04177
TAP42-like family; The TOR signalling pathway activates a cell-growth program in response to ...
 17-330 9.28e-98

TAP42-like family; The TOR signalling pathway activates a cell-growth program in response to nutrients. TIP41 (pfam04176) interacts with TAP42 and negatively regulates the TOR signaling pathway.


Pssm-ID: 461209  Cd Length: 305  Bit Score: 291.43  E-value: 9.28e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304555605   17 FETSKKLLEDVEvATEPTGSRTIQDKVSKGLELLEKAAGMLSQLDLFSRNEDLEEIASTDLKYLMVPALQGALTMKQVN- 95
Cdd:pfam04177   5 FDSALKLYEELE-NSTPTNSPEYQDKVKSAIALLELCTKLVSQLSLFSSNETLEDISTSDLKYLLVPYYLGELTQKLQTd 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304555605   96 PSKRLDHLQRAREHFVHFLTQCHCYHVAEFQLPQ--TKTNSAENNTASSSMAYPNLVAMASQRQAKIERYKQKKEVEHRL 173
Cdd:pfam04177  84 PEDRLEVLKRAREYYEDFLKRLEDYELLPKEDKKllESFSSENYSELPELFSTASTSDAAARREEKIARFKREKELEQKL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304555605  174 SALKSAVES--GQADDERVREYHLLHLRRWIAVSLEELESIDQEIKILKEKdspreetachsslpEKPPMKPFIL--TRN 249
Cdd:pfam04177 164 EELKKRVESrsGQEDEEVVRELYLTQLKLAILKAFQELESIEQELEILEMA--------------PGKPLRPFTIlsTRE 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304555605  250 KAQAKVFGTGYpSLATMTVSDWYEQHQKYGVLPDRGiaKPASADFQRAAQQQEDQEQKDEESEEkaLHRMREWDDWKDTH 329
Cdd:pfam04177 230 ELQAKVFGPGH-SLPTMTVDEYLEEERRRGGIIEGG--GEASAAEPEEEEEEDEEDDEEKADEE--TYKAREWDEFKDDN 304


                  .
gi 304555605  330 P 330
Cdd:pfam04177 305 P 305
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH