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Conserved domains on  [gi|213417929|ref|NP_033142|]
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paired mesoderm homeobox protein 2 [Mus musculus]

Protein Classification

homeodomain and OAR domain-containing protein( domain architecture ID 13612943)

homeodomain and OAR domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
103-155 2.56e-27

Homeodomain;


:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 99.50  E-value: 2.56e-27
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 213417929  103 TTFNSSQLQALERVFERTHYPDAFVREELARRVNLSEARVQVWFQNRRAKFRR 155
Cdd:pfam00046   5 TTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
COG5576 super family cl35021
Homeodomain-containing transcription factor [Transcription];
109-213 3.50e-12

Homeodomain-containing transcription factor [Transcription];


The actual alignment was detected with superfamily member COG5576:

Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 62.45  E-value: 3.50e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213417929 109 QLQALERVFERTHYPDAFVREELARRVNLSEARVQVWFQNRRAKFRR----NERAMLATRSASLLKSygqeaaieqpvaP 184
Cdd:COG5576   62 QLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKkrsgKVEQRPGEEEADLAKI------------G 129

                         90       100
                 ....*....|....*....|....*....
gi 213417929 185 RPTTMSPDYLSWPASSPyssvPPYSPGGS 213
Cdd:COG5576  130 SLSTGQISIIETLEFSR----TSYEEGGL 154
OAR pfam03826
OAR motif; The entry represents the OAR motif.
 221-237 6.75e-03

OAR motif; The entry represents the OAR motif.


:

Pssm-ID: 461067  Cd Length: 19  Bit Score: 33.15  E-value: 6.75e-03
                          10
                  ....*....|....*..
gi 213417929  221 NMANSIASLRLKAKEFS 237
Cdd:pfam03826   2 RRSSSIASLRLKAKEHS 18
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
103-155 2.56e-27

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 99.50  E-value: 2.56e-27
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 213417929  103 TTFNSSQLQALERVFERTHYPDAFVREELARRVNLSEARVQVWFQNRRAKFRR 155
Cdd:pfam00046   5 TTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 103-157 2.47e-23

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 89.22  E-value: 2.47e-23
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 213417929 103 TTFNSSQLQALERVFERTHYPDAFVREELARRVNLSEARVQVWFQNRRAKFRRNE 157
Cdd:cd00086    5 TRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 103-154 2.05e-22

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 86.92  E-value: 2.05e-22
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 213417929   103 TTFNSSQLQALERVFERTHYPDAFVREELARRVNLSEARVQVWFQNRRAKFR 154
Cdd:smart00389   6 TSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
109-213 3.50e-12

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 62.45  E-value: 3.50e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213417929 109 QLQALERVFERTHYPDAFVREELARRVNLSEARVQVWFQNRRAKFRR----NERAMLATRSASLLKSygqeaaieqpvaP 184
Cdd:COG5576   62 QLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKkrsgKVEQRPGEEEADLAKI------------G 129

                         90       100
                 ....*....|....*....|....*....
gi 213417929 185 RPTTMSPDYLSWPASSPyssvPPYSPGGS 213
Cdd:COG5576  130 SLSTGQISIIETLEFSR----TSYEEGGL 154
OAR pfam03826
OAR motif; The entry represents the OAR motif.
 221-237 6.75e-03

OAR motif; The entry represents the OAR motif.


Pssm-ID: 461067  Cd Length: 19  Bit Score: 33.15  E-value: 6.75e-03
                          10
                  ....*....|....*..
gi 213417929  221 NMANSIASLRLKAKEFS 237
Cdd:pfam03826   2 RRSSSIASLRLKAKEHS 18
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
103-155 2.56e-27

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 99.50  E-value: 2.56e-27
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 213417929  103 TTFNSSQLQALERVFERTHYPDAFVREELARRVNLSEARVQVWFQNRRAKFRR 155
Cdd:pfam00046   5 TTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 103-157 2.47e-23

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 89.22  E-value: 2.47e-23
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 213417929 103 TTFNSSQLQALERVFERTHYPDAFVREELARRVNLSEARVQVWFQNRRAKFRRNE 157
Cdd:cd00086    5 TRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 103-154 2.05e-22

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 86.92  E-value: 2.05e-22
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 213417929   103 TTFNSSQLQALERVFERTHYPDAFVREELARRVNLSEARVQVWFQNRRAKFR 154
Cdd:smart00389   6 TSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
109-213 3.50e-12

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 62.45  E-value: 3.50e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213417929 109 QLQALERVFERTHYPDAFVREELARRVNLSEARVQVWFQNRRAKFRR----NERAMLATRSASLLKSygqeaaieqpvaP 184
Cdd:COG5576   62 QLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKkrsgKVEQRPGEEEADLAKI------------G 129

                         90       100
                 ....*....|....*....|....*....
gi 213417929 185 RPTTMSPDYLSWPASSPyssvPPYSPGGS 213
Cdd:COG5576  130 SLSTGQISIIETLEFSR----TSYEEGGL 154
Homeobox_KN pfam05920
Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to ...
 122-155 2.28e-03

Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to human and plants. They were first identified as TALE homeobox genes in eukaryotes, (including KNOX and MEIS genes). They have been recently classified.


Pssm-ID: 428673  Cd Length: 39  Bit Score: 34.80  E-value: 2.28e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 213417929  122 YPDAFVREELARRVNLSEARVQVWFQNRRakfRR 155
Cdd:pfam05920   9 YPSEEEKAELAKETGLSRKQISNWFINAR---RR 39
OAR pfam03826
OAR motif; The entry represents the OAR motif.
 221-237 6.75e-03

OAR motif; The entry represents the OAR motif.


Pssm-ID: 461067  Cd Length: 19  Bit Score: 33.15  E-value: 6.75e-03
                          10
                  ....*....|....*..
gi 213417929  221 NMANSIASLRLKAKEFS 237
Cdd:pfam03826   2 RRSSSIASLRLKAKEHS 18
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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