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Conserved domains on  [gi|6753646|ref|NP_034184|]
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homeobox protein DLX-2 [Mus musculus]

Protein Classification

DLL_N and homeodomain domain-containing protein( domain architecture ID 11193609)

DLL_N and homeodomain domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
156-212 7.59e-27

Homeodomain;


:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 100.27  E-value: 7.59e-27
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 6753646    156 RKPRTIYSSFQLAALQRRFQKTQYLALPERAELAASLGLTQTQVKIWFQNRRSKFKK 212
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
DLL_N pfam12413
Homeobox protein distal-less-like N terminal; This domain family is found in eukaryotes, and ...
 54-135 5.36e-14

Homeobox protein distal-less-like N terminal; This domain family is found in eukaryotes, and is approximately 80 amino acids in length. The family is found in association with pfam00046. This family is the N terminal of a homeobox protein involved in embryonic development and adult neural regeneration.


:

Pssm-ID: 463567  Cd Length: 83  Bit Score: 66.30  E-value: 5.36e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753646     54 QESPTLPVSTATDSSYYTNQQHPAGGGGGGASPYAHMGSYQY-HASGLNNV-SYSAKsSYDLGYTAAYTSYAPYGTSSSP 131
Cdd:pfam12413   1 QDSPTLPESSATDSGYYSPQQQHYYGSCAGQPYGQPLNSYQYfNLNGMNGTgAYSTK-AYEYGYNTSYRQYGAYGRSQSP 79


                  ....
gi 6753646    132 VNNE 135
Cdd:pfam12413  80 PPQD 83
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
156-212 7.59e-27

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 100.27  E-value: 7.59e-27
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 6753646    156 RKPRTIYSSFQLAALQRRFQKTQYLALPERAELAASLGLTQTQVKIWFQNRRSKFKK 212
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 156-211 9.85e-24

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 91.93  E-value: 9.85e-24
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 6753646     156 RKPRTIYSSFQLAALQRRFQKTQYLALPERAELAASLGLTQTQVKIWFQNRRSKFK 211
Cdd:smart00389   2 RRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 156-214 4.80e-23

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 90.38  E-value: 4.80e-23
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 6753646  156 RKPRTIYSSFQLAALQRRFQKTQYLALPERAELAASLGLTQTQVKIWFQNRRSKFKKMW 214
Cdd:cd00086   1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
DLL_N pfam12413
Homeobox protein distal-less-like N terminal; This domain family is found in eukaryotes, and ...
 54-135 5.36e-14

Homeobox protein distal-less-like N terminal; This domain family is found in eukaryotes, and is approximately 80 amino acids in length. The family is found in association with pfam00046. This family is the N terminal of a homeobox protein involved in embryonic development and adult neural regeneration.


Pssm-ID: 463567  Cd Length: 83  Bit Score: 66.30  E-value: 5.36e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753646     54 QESPTLPVSTATDSSYYTNQQHPAGGGGGGASPYAHMGSYQY-HASGLNNV-SYSAKsSYDLGYTAAYTSYAPYGTSSSP 131
Cdd:pfam12413   1 QDSPTLPESSATDSGYYSPQQQHYYGSCAGQPYGQPLNSYQYfNLNGMNGTgAYSTK-AYEYGYNTSYRQYGAYGRSQSP 79


                  ....
gi 6753646    132 VNNE 135
Cdd:pfam12413  80 PPQD 83
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
151-233 2.35e-11

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 61.30  E-value: 2.35e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753646  151 KPKKVRKprtiySSFQLAALQRRFQKTQYLALPERAELAASLGLTQTQVKIWFQNRRSKFKKMWKSGE---IPTEQHPGA 227
Cdd:COG5576  52 KSKRRRT-----TDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKRSGKVeqrPGEEEADLA 126


                ....*.
gi 6753646  228 SASPPC 233
Cdd:COG5576 127 KIGSLS 132
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
156-212 7.59e-27

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 100.27  E-value: 7.59e-27
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 6753646    156 RKPRTIYSSFQLAALQRRFQKTQYLALPERAELAASLGLTQTQVKIWFQNRRSKFKK 212
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 156-211 9.85e-24

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 91.93  E-value: 9.85e-24
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 6753646     156 RKPRTIYSSFQLAALQRRFQKTQYLALPERAELAASLGLTQTQVKIWFQNRRSKFK 211
Cdd:smart00389   2 RRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 156-214 4.80e-23

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 90.38  E-value: 4.80e-23
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 6753646  156 RKPRTIYSSFQLAALQRRFQKTQYLALPERAELAASLGLTQTQVKIWFQNRRSKFKKMW 214
Cdd:cd00086   1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
DLL_N pfam12413
Homeobox protein distal-less-like N terminal; This domain family is found in eukaryotes, and ...
 54-135 5.36e-14

Homeobox protein distal-less-like N terminal; This domain family is found in eukaryotes, and is approximately 80 amino acids in length. The family is found in association with pfam00046. This family is the N terminal of a homeobox protein involved in embryonic development and adult neural regeneration.


Pssm-ID: 463567  Cd Length: 83  Bit Score: 66.30  E-value: 5.36e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753646     54 QESPTLPVSTATDSSYYTNQQHPAGGGGGGASPYAHMGSYQY-HASGLNNV-SYSAKsSYDLGYTAAYTSYAPYGTSSSP 131
Cdd:pfam12413   1 QDSPTLPESSATDSGYYSPQQQHYYGSCAGQPYGQPLNSYQYfNLNGMNGTgAYSTK-AYEYGYNTSYRQYGAYGRSQSP 79


                  ....
gi 6753646    132 VNNE 135
Cdd:pfam12413  80 PPQD 83
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
151-233 2.35e-11

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 61.30  E-value: 2.35e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753646  151 KPKKVRKprtiySSFQLAALQRRFQKTQYLALPERAELAASLGLTQTQVKIWFQNRRSKFKKMWKSGE---IPTEQHPGA 227
Cdd:COG5576  52 KSKRRRT-----TDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKRSGKVeqrPGEEEADLA 126


                ....*.
gi 6753646  228 SASPPC 233
Cdd:COG5576 127 KIGSLS 132
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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