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transcription factor COE2 [Mus musculus]
transcription factor COE( domain architecture ID 11242836)
transcription factor COE similar to human COE1 and COE2 that recognize variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3, and may play roles in B-cell development
List of domain hits
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Name | Accession | Description | Interval | E-value | ||||
COE1_DBD | pfam16422 | Transcription factor COE1 DNA-binding domain; |
20-246 | 4.60e-174 | ||||
Transcription factor COE1 DNA-binding domain; : Pssm-ID: 435333 Cd Length: 227 Bit Score: 491.28 E-value: 4.60e-174
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IPT_COE | cd01175 | IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing ... |
253-337 | 1.78e-56 | ||||
IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved in the regulation of the early stages of B-cell differentiation, Drosophila collier is a regulator of the head patterning, and a related protein in Xenopus is involved in primary neurogenesis. All COE family members have a well conserved DNA binding domain that contains an atypical Zn finger motif. The function of the IPT domain is unknown. : Pssm-ID: 238580 Cd Length: 85 Bit Score: 184.39 E-value: 1.78e-56
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COE1_HLH | pfam16423 | Transcription factor COE1 helix-loop-helix domain; This is the helix-loop-helix domain of ... |
338-381 | 1.05e-24 | ||||
Transcription factor COE1 helix-loop-helix domain; This is the helix-loop-helix domain of transcription factor COE1. It is responsible for dimerization. : Pssm-ID: 406751 Cd Length: 44 Bit Score: 96.78 E-value: 1.05e-24
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Name | Accession | Description | Interval | E-value | ||||
COE1_DBD | pfam16422 | Transcription factor COE1 DNA-binding domain; |
20-246 | 4.60e-174 | ||||
Transcription factor COE1 DNA-binding domain; Pssm-ID: 435333 Cd Length: 227 Bit Score: 491.28 E-value: 4.60e-174
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COE_DBD | cd11606 | Colier/Olf/Early B-cell factor (EBF) DNA Binding Domain; COE_DBD is the amino-terminal DNA ... |
34-246 | 4.09e-169 | ||||
Colier/Olf/Early B-cell factor (EBF) DNA Binding Domain; COE_DBD is the amino-terminal DNA binding domain of the COE protein family. The COE transcription factor is a regulator of development in several organs and tissues that contain the DBD domain as well as IPT/TIG (immunoglobulin-like, Plexins, transcription factors/transcription factor immunoglobulin) and basic helix-loop-helix (bHLH) domains. COE has four members in mammals (COE1-4) with high sequence similarity at the amino-terminal region. COE_DBD requires a zinc ion to bind DNA and contains a zinc finger motif (H-X(3)-C-X(2)-C-X(5)-C) termed the zinc knuckle. COE is homo- or heterodimerized through the bHLH domain to bind DNA. COE1-4 each has a variant due to alternative splicing. However, this alternative splicing does not occur at the DBD domain. Pssm-ID: 212156 Cd Length: 212 Bit Score: 478.08 E-value: 4.09e-169
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IPT_COE | cd01175 | IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing ... |
253-337 | 1.78e-56 | ||||
IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved in the regulation of the early stages of B-cell differentiation, Drosophila collier is a regulator of the head patterning, and a related protein in Xenopus is involved in primary neurogenesis. All COE family members have a well conserved DNA binding domain that contains an atypical Zn finger motif. The function of the IPT domain is unknown. Pssm-ID: 238580 Cd Length: 85 Bit Score: 184.39 E-value: 1.78e-56
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COE1_HLH | pfam16423 | Transcription factor COE1 helix-loop-helix domain; This is the helix-loop-helix domain of ... |
338-381 | 1.05e-24 | ||||
Transcription factor COE1 helix-loop-helix domain; This is the helix-loop-helix domain of transcription factor COE1. It is responsible for dimerization. Pssm-ID: 406751 Cd Length: 44 Bit Score: 96.78 E-value: 1.05e-24
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TIG | pfam01833 | IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ... |
253-335 | 2.54e-14 | ||||
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members. Pssm-ID: 460355 [Multi-domain] Cd Length: 84 Bit Score: 68.24 E-value: 2.54e-14
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IPT | smart00429 | ig-like, plexins, transcription factors; |
253-336 | 1.19e-06 | ||||
ig-like, plexins, transcription factors; Pssm-ID: 214657 [Multi-domain] Cd Length: 90 Bit Score: 46.64 E-value: 1.19e-06
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Name | Accession | Description | Interval | E-value | ||||
COE1_DBD | pfam16422 | Transcription factor COE1 DNA-binding domain; |
20-246 | 4.60e-174 | ||||
Transcription factor COE1 DNA-binding domain; Pssm-ID: 435333 Cd Length: 227 Bit Score: 491.28 E-value: 4.60e-174
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COE_DBD | cd11606 | Colier/Olf/Early B-cell factor (EBF) DNA Binding Domain; COE_DBD is the amino-terminal DNA ... |
34-246 | 4.09e-169 | ||||
Colier/Olf/Early B-cell factor (EBF) DNA Binding Domain; COE_DBD is the amino-terminal DNA binding domain of the COE protein family. The COE transcription factor is a regulator of development in several organs and tissues that contain the DBD domain as well as IPT/TIG (immunoglobulin-like, Plexins, transcription factors/transcription factor immunoglobulin) and basic helix-loop-helix (bHLH) domains. COE has four members in mammals (COE1-4) with high sequence similarity at the amino-terminal region. COE_DBD requires a zinc ion to bind DNA and contains a zinc finger motif (H-X(3)-C-X(2)-C-X(5)-C) termed the zinc knuckle. COE is homo- or heterodimerized through the bHLH domain to bind DNA. COE1-4 each has a variant due to alternative splicing. However, this alternative splicing does not occur at the DBD domain. Pssm-ID: 212156 Cd Length: 212 Bit Score: 478.08 E-value: 4.09e-169
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IPT_COE | cd01175 | IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing ... |
253-337 | 1.78e-56 | ||||
IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved in the regulation of the early stages of B-cell differentiation, Drosophila collier is a regulator of the head patterning, and a related protein in Xenopus is involved in primary neurogenesis. All COE family members have a well conserved DNA binding domain that contains an atypical Zn finger motif. The function of the IPT domain is unknown. Pssm-ID: 238580 Cd Length: 85 Bit Score: 184.39 E-value: 1.78e-56
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COE1_HLH | pfam16423 | Transcription factor COE1 helix-loop-helix domain; This is the helix-loop-helix domain of ... |
338-381 | 1.05e-24 | ||||
Transcription factor COE1 helix-loop-helix domain; This is the helix-loop-helix domain of transcription factor COE1. It is responsible for dimerization. Pssm-ID: 406751 Cd Length: 44 Bit Score: 96.78 E-value: 1.05e-24
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TIG | pfam01833 | IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ... |
253-335 | 2.54e-14 | ||||
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members. Pssm-ID: 460355 [Multi-domain] Cd Length: 84 Bit Score: 68.24 E-value: 2.54e-14
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IPT | cd00102 | Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ... |
253-336 | 5.50e-11 | ||||
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers. Pssm-ID: 238050 [Multi-domain] Cd Length: 89 Bit Score: 59.01 E-value: 5.50e-11
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IPT | smart00429 | ig-like, plexins, transcription factors; |
253-336 | 1.19e-06 | ||||
ig-like, plexins, transcription factors; Pssm-ID: 214657 [Multi-domain] Cd Length: 90 Bit Score: 46.64 E-value: 1.19e-06
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IPT_TF | cd00602 | IPT domain of eukaryotic transcription factors NF-kappaB/Rel, nuclear factor of activated ... |
255-336 | 2.23e-03 | ||||
IPT domain of eukaryotic transcription factors NF-kappaB/Rel, nuclear factor of activated Tcells (NFAT), and recombination signal J-kappa binding protein (RBP-Jkappa). The IPT domains in these proteins are involved in DNA binding. Most NF-kappaB/Rel proteins form homo- and heterodimers, while NFAT proteins are largely monomeric (with TonEBP being an exception). While the majority of sequence-specific DNA binding elements are found in the N-terminal domain, several are found in the IPT domain in loops adjacent to, and including, the linker region. Pssm-ID: 238336 Cd Length: 101 Bit Score: 37.65 E-value: 2.23e-03
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Blast search parameters | ||||
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