NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|46879190|ref|NP_034233|]
View 

EGF-like repeat and discoidin I-like domain-containing protein 3 isoform b precursor [Mus musculus]

Protein Classification

calcium-binding EGF-like domain-containing protein( domain architecture ID 10439819)

calcium-binding epidermal growth factor (EGF)-like domain-containing protein may play a crucial role in numerous protein-protein interactions

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 150-303 3.02e-63

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


:

Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 201.43  E-value: 3.02e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46879190 150 GPLGIEGGIiSNQQITASSTHRAlfglqKWYPYYARLNKkglINAWTAAENDRWPWIQINLQRKMRVTGVITQGAKRIGS 229
Cdd:cd00057   1 EPLGMESGL-ADDQITASSSYSS-----GWEASRARLNS---DNAWTPAVNDPPQWLQVDLGKTRRVTGIQTQGRKGGGS 71

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 46879190 230 PEYIKSYKIAYSNDGKTWAMYKVKGtnEEMVFRGNVDNNTPYANSFTPPIKAQYVRLYPQICRRHCTLRMELLG 303
Cdd:cd00057  72 SEWVTSYKVQYSLDGETWTTYKDKG--EEKVFTGNSDGSTPVTNDFPPPIVARYIRILPTTWNGNISLRLELYG 143
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 311-465 1.04e-52

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


:

Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 174.08  E-value: 1.04e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46879190 311 EPLGMKSGHiQDYQITASSVFRTlnmdmfTWEPRKARLDKqgkVNAWTSGHNDQSQWLQVDLLVPTKVTGIITQGAKDFG 390
Cdd:cd00057   1 EPLGMESGL-ADDQITASSSYSS------GWEASRARLNS---DNAWTPAVNDPPQWLQVDLGKTRRVTGIQTQGRKGGG 70

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 46879190 391 HVQFVGSYKLAYSNDGEHWMVHQDekQRKDKVFQGNFDNDTHRKNVIDPPIYARFIRILPWSWYGRITLRSELLG 465
Cdd:cd00057  71 SSEWVTSYKVQYSLDGETWTTYKD--KGEEKVFTGNSDGSTPVTNDFPPPIVARYIRILPTTWNGNISLRLELYG 143
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 109-145 3.72e-09

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 51.87  E-value: 3.72e-09
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 46879190 109 NINECE-AEPCRNGGICTDLVANYSCECPGEFMGRNCQ 145
Cdd:cd00054   1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 26-58 3.32e-06

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 43.53  E-value: 3.32e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 46879190    26 CNPNPCENGGICLSGLadDSFSCECPEGFAGPN 58
Cdd:pfam00008   1 CAPNPCSNGGTCVDTP--GGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 70-107 2.30e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.47  E-value: 2.30e-05
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 46879190  70 PNPCHNGGTCEiseayrgDTFIGYVCKCPRGFNGIHCQ 107
Cdd:cd00054   8 GNPCQNGGTCV-------NTVGSYRCSCPPGYTGRNCE 38
 
Name Accession Description Interval E-value
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 150-303 3.02e-63

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 201.43  E-value: 3.02e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46879190 150 GPLGIEGGIiSNQQITASSTHRAlfglqKWYPYYARLNKkglINAWTAAENDRWPWIQINLQRKMRVTGVITQGAKRIGS 229
Cdd:cd00057   1 EPLGMESGL-ADDQITASSSYSS-----GWEASRARLNS---DNAWTPAVNDPPQWLQVDLGKTRRVTGIQTQGRKGGGS 71

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 46879190 230 PEYIKSYKIAYSNDGKTWAMYKVKGtnEEMVFRGNVDNNTPYANSFTPPIKAQYVRLYPQICRRHCTLRMELLG 303
Cdd:cd00057  72 SEWVTSYKVQYSLDGETWTTYKDKG--EEKVFTGNSDGSTPVTNDFPPPIVARYIRILPTTWNGNISLRLELYG 143
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 311-465 1.04e-52

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 174.08  E-value: 1.04e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46879190 311 EPLGMKSGHiQDYQITASSVFRTlnmdmfTWEPRKARLDKqgkVNAWTSGHNDQSQWLQVDLLVPTKVTGIITQGAKDFG 390
Cdd:cd00057   1 EPLGMESGL-ADDQITASSSYSS------GWEASRARLNS---DNAWTPAVNDPPQWLQVDLGKTRRVTGIQTQGRKGGG 70

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 46879190 391 HVQFVGSYKLAYSNDGEHWMVHQDekQRKDKVFQGNFDNDTHRKNVIDPPIYARFIRILPWSWYGRITLRSELLG 465
Cdd:cd00057  71 SSEWVTSYKVQYSLDGETWTTYKD--KGEEKVFTGNSDGSTPVTNDFPPPIVARYIRILPTTWNGNISLRLELYG 143
FA58C smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 147-304 1.59e-45

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 214572  Cd Length: 139  Bit Score: 155.36  E-value: 1.59e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46879190    147 KCSGPLGIEggiiSNQQITASSthralfglQKWYPYYARLNKkGLINAWTAAENDRWPWIQINLQRKMRVTGVITQGakR 226
Cdd:smart00231   1 PCNEPLGLE----SDSQITASS--------SYWAAKIARLNG-GSDGGWCPAKNDLPPWIQVDLGRLRTVTGVITGR--R 65

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 46879190    227 IGSPEYIKsYKIAYSNDGKTWAMYKVKgtnEEMVFRGNVDNNTPYANSFTPPIKAQYVRLYPQICRRHCTLRMELLGC 304
Cdd:smart00231  66 HGNGDWVT-YKLEYSDDGVNWTTYKDG---NSKVFPGNSDAGTVVLNDFPPPIVARYVRILPTGWNGNIILRVELLGC 139
FA58C smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 308-466 5.95e-38

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 214572  Cd Length: 139  Bit Score: 134.94  E-value: 5.95e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46879190    308 GCSEPLGMKSghiqDYQITASSVFrtlnmdmftWEPRKARLDkQGKVNAWTSGHNDQSQWLQVDLLVPTKVTGIITQGAK 387
Cdd:smart00231   1 PCNEPLGLES----DSQITASSSY---------WAAKIARLN-GGSDGGWCPAKNDLPPWIQVDLGRLRTVTGVITGRRH 66

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 46879190    388 DFGHVQfvgSYKLAYSNDGEHWMVhqdEKQRKDKVFQGNFDNDTHRKNVIDPPIYARFIRILPWSWYGRITLRSELLGC 466
Cdd:smart00231  67 GNGDWV---TYKLEYSDDGVNWTT---YKDGNSKVFPGNSDAGTVVLNDFPPPIVARYVRILPTGWNGNIILRVELLGC 139
F5_F8_type_C pfam00754
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.
 324-463 3.23e-36

F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.


Pssm-ID: 459925 [Multi-domain]  Cd Length: 127  Bit Score: 129.87  E-value: 3.23e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46879190   324 QITASSVFRTlnmdmfTWEPRkARLDkqGKVN-AWTSGHNDQSQWLQVDLLVPTKVTGIITQGAKDfGHVQFVGSYKLAY 402
Cdd:pfam00754   1 QITASSSYSG------EGPAA-AALD--GDPNtAWSAWSGDDPQWIQVDLGKPKKITGVVTQGRQD-GSNGYVTSYKIEY 70

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 46879190   403 SNDGEHWMVHQDEKqrkdkvFQGNFDNDTHRKNVIDPPIYARFIRILPWSW--YGRITLRSEL 463
Cdd:pfam00754  71 SLDGENWTTVKDEK------IPGNNDNNTPVTNTFDPPIKARYVRIVPTSWngGNGIALRAEL 127
F5_F8_type_C pfam00754
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.
 163-301 5.67e-32

F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.


Pssm-ID: 459925 [Multi-domain]  Cd Length: 127  Bit Score: 118.70  E-value: 5.67e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46879190   163 QITASSTHRALfglqkwYPYYARLNKKgLINAWTAAENDRWPWIQINLQRKMRVTGVITQGAKRiGSPEYIKSYKIAYSN 242
Cdd:pfam00754   1 QITASSSYSGE------GPAAAALDGD-PNTAWSAWSGDDPQWIQVDLGKPKKITGVVTQGRQD-GSNGYVTSYKIEYSL 72

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 46879190   243 DGKTWAMYKVKGTNeemvfrGNVDNNTPYANSFTPPIKAQYVRLYPQ--ICRRHCTLRMEL 301
Cdd:pfam00754  73 DGENWTTVKDEKIP------GNNDNNTPVTNTFDPPIKARYVRIVPTswNGGNGIALRAEL 127
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 109-145 3.72e-09

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 51.87  E-value: 3.72e-09
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 46879190 109 NINECE-AEPCRNGGICTDLVANYSCECPGEFMGRNCQ 145
Cdd:cd00054   1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
109-145 6.90e-08

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.40  E-value: 6.90e-08
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 46879190    109 NINECEAE-PCRNGGICTDLVANYSCECPGEFM-GRNCQ 145
Cdd:smart00179   1 DIDECASGnPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 26-58 3.32e-06

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 43.53  E-value: 3.32e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 46879190    26 CNPNPCENGGICLSGLadDSFSCECPEGFAGPN 58
Cdd:pfam00008   1 CAPNPCSNGGTCVDTP--GGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 28-59 1.14e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 1.14e-05
                        10        20        30
                ....*....|....*....|....*....|..
gi 46879190  28 PNPCENGGICLSGlaDDSFSCECPEGFAGPNC 59
Cdd:cd00054   8 GNPCQNGGTCVNT--VGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 70-107 2.30e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.47  E-value: 2.30e-05
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 46879190  70 PNPCHNGGTCEiseayrgDTFIGYVCKCPRGFNGIHCQ 107
Cdd:cd00054   8 GNPCQNGGTCV-------NTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
70-107 2.55e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 2.55e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 46879190     70 PNPCHNGGTCEiseayrgDTFIGYVCKCPRGF-NGIHCQ 107
Cdd:smart00179   8 GNPCQNGGTCV-------NTVGSYRCECPPGYtDGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 68-105 2.64e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.13  E-value: 2.64e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 46879190    68 CIPNPCHNGGTCEiseayrgDTFIGYVCKCPRGFNGIH 105
Cdd:pfam00008   1 CAPNPCSNGGTCV-------DTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
28-59 5.17e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 5.17e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 46879190     28 PNPCENGGICLSGLadDSFSCECPEGF-AGPNC 59
Cdd:smart00179   8 GNPCQNGGTCVNTV--GSYRCECPPGYtDGRNC 38
 
Name Accession Description Interval E-value
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 150-303 3.02e-63

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 201.43  E-value: 3.02e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46879190 150 GPLGIEGGIiSNQQITASSTHRAlfglqKWYPYYARLNKkglINAWTAAENDRWPWIQINLQRKMRVTGVITQGAKRIGS 229
Cdd:cd00057   1 EPLGMESGL-ADDQITASSSYSS-----GWEASRARLNS---DNAWTPAVNDPPQWLQVDLGKTRRVTGIQTQGRKGGGS 71

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 46879190 230 PEYIKSYKIAYSNDGKTWAMYKVKGtnEEMVFRGNVDNNTPYANSFTPPIKAQYVRLYPQICRRHCTLRMELLG 303
Cdd:cd00057  72 SEWVTSYKVQYSLDGETWTTYKDKG--EEKVFTGNSDGSTPVTNDFPPPIVARYIRILPTTWNGNISLRLELYG 143
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 311-465 1.04e-52

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 174.08  E-value: 1.04e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46879190 311 EPLGMKSGHiQDYQITASSVFRTlnmdmfTWEPRKARLDKqgkVNAWTSGHNDQSQWLQVDLLVPTKVTGIITQGAKDFG 390
Cdd:cd00057   1 EPLGMESGL-ADDQITASSSYSS------GWEASRARLNS---DNAWTPAVNDPPQWLQVDLGKTRRVTGIQTQGRKGGG 70

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 46879190 391 HVQFVGSYKLAYSNDGEHWMVHQDekQRKDKVFQGNFDNDTHRKNVIDPPIYARFIRILPWSWYGRITLRSELLG 465
Cdd:cd00057  71 SSEWVTSYKVQYSLDGETWTTYKD--KGEEKVFTGNSDGSTPVTNDFPPPIVARYIRILPTTWNGNISLRLELYG 143
FA58C smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 147-304 1.59e-45

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 214572  Cd Length: 139  Bit Score: 155.36  E-value: 1.59e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46879190    147 KCSGPLGIEggiiSNQQITASSthralfglQKWYPYYARLNKkGLINAWTAAENDRWPWIQINLQRKMRVTGVITQGakR 226
Cdd:smart00231   1 PCNEPLGLE----SDSQITASS--------SYWAAKIARLNG-GSDGGWCPAKNDLPPWIQVDLGRLRTVTGVITGR--R 65

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 46879190    227 IGSPEYIKsYKIAYSNDGKTWAMYKVKgtnEEMVFRGNVDNNTPYANSFTPPIKAQYVRLYPQICRRHCTLRMELLGC 304
Cdd:smart00231  66 HGNGDWVT-YKLEYSDDGVNWTTYKDG---NSKVFPGNSDAGTVVLNDFPPPIVARYVRILPTGWNGNIILRVELLGC 139
FA58C smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 308-466 5.95e-38

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 214572  Cd Length: 139  Bit Score: 134.94  E-value: 5.95e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46879190    308 GCSEPLGMKSghiqDYQITASSVFrtlnmdmftWEPRKARLDkQGKVNAWTSGHNDQSQWLQVDLLVPTKVTGIITQGAK 387
Cdd:smart00231   1 PCNEPLGLES----DSQITASSSY---------WAAKIARLN-GGSDGGWCPAKNDLPPWIQVDLGRLRTVTGVITGRRH 66

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 46879190    388 DFGHVQfvgSYKLAYSNDGEHWMVhqdEKQRKDKVFQGNFDNDTHRKNVIDPPIYARFIRILPWSWYGRITLRSELLGC 466
Cdd:smart00231  67 GNGDWV---TYKLEYSDDGVNWTT---YKDGNSKVFPGNSDAGTVVLNDFPPPIVARYVRILPTGWNGNIILRVELLGC 139
F5_F8_type_C pfam00754
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.
 324-463 3.23e-36

F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.


Pssm-ID: 459925 [Multi-domain]  Cd Length: 127  Bit Score: 129.87  E-value: 3.23e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46879190   324 QITASSVFRTlnmdmfTWEPRkARLDkqGKVN-AWTSGHNDQSQWLQVDLLVPTKVTGIITQGAKDfGHVQFVGSYKLAY 402
Cdd:pfam00754   1 QITASSSYSG------EGPAA-AALD--GDPNtAWSAWSGDDPQWIQVDLGKPKKITGVVTQGRQD-GSNGYVTSYKIEY 70

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 46879190   403 SNDGEHWMVHQDEKqrkdkvFQGNFDNDTHRKNVIDPPIYARFIRILPWSW--YGRITLRSEL 463
Cdd:pfam00754  71 SLDGENWTTVKDEK------IPGNNDNNTPVTNTFDPPIKARYVRIVPTSWngGNGIALRAEL 127
F5_F8_type_C pfam00754
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.
 163-301 5.67e-32

F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.


Pssm-ID: 459925 [Multi-domain]  Cd Length: 127  Bit Score: 118.70  E-value: 5.67e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46879190   163 QITASSTHRALfglqkwYPYYARLNKKgLINAWTAAENDRWPWIQINLQRKMRVTGVITQGAKRiGSPEYIKSYKIAYSN 242
Cdd:pfam00754   1 QITASSSYSGE------GPAAAALDGD-PNTAWSAWSGDDPQWIQVDLGKPKKITGVVTQGRQD-GSNGYVTSYKIEYSL 72

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 46879190   243 DGKTWAMYKVKGTNeemvfrGNVDNNTPYANSFTPPIKAQYVRLYPQ--ICRRHCTLRMEL 301
Cdd:pfam00754  73 DGENWTTVKDEKIP------GNNDNNTPVTNTFDPPIKARYVRIVPTswNGGNGIALRAEL 127
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 109-145 3.72e-09

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 51.87  E-value: 3.72e-09
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 46879190 109 NINECE-AEPCRNGGICTDLVANYSCECPGEFMGRNCQ 145
Cdd:cd00054   1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
109-145 6.90e-08

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.40  E-value: 6.90e-08
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 46879190    109 NINECEAE-PCRNGGICTDLVANYSCECPGEFM-GRNCQ 145
Cdd:smart00179   1 DIDECASGnPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 26-58 3.32e-06

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 43.53  E-value: 3.32e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 46879190    26 CNPNPCENGGICLSGLadDSFSCECPEGFAGPN 58
Cdd:pfam00008   1 CAPNPCSNGGTCVDTP--GGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 28-59 1.14e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 1.14e-05
                        10        20        30
                ....*....|....*....|....*....|..
gi 46879190  28 PNPCENGGICLSGlaDDSFSCECPEGFAGPNC 59
Cdd:cd00054   8 GNPCQNGGTCVNT--VGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 70-107 2.30e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.47  E-value: 2.30e-05
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 46879190  70 PNPCHNGGTCEiseayrgDTFIGYVCKCPRGFNGIHCQ 107
Cdd:cd00054   8 GNPCQNGGTCV-------NTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
70-107 2.55e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 2.55e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 46879190     70 PNPCHNGGTCEiseayrgDTFIGYVCKCPRGF-NGIHCQ 107
Cdd:smart00179   8 GNPCQNGGTCV-------NTVGSYRCECPPGYtDGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 68-105 2.64e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.13  E-value: 2.64e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 46879190    68 CIPNPCHNGGTCEiseayrgDTFIGYVCKCPRGFNGIH 105
Cdd:pfam00008   1 CAPNPCSNGGTCV-------DTPGGYTCICPEGYTGKR 31
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 112-145 4.75e-04

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 37.46  E-value: 4.75e-04
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 46879190 112 ECEAE-PCRNGGICTDLVANYSCECPGEFMG-RNCQ 145
Cdd:cd00053   1 ECAASnPCSNGGTCVNTPGSYRCVCPPGYTGdRSCE 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
28-59 5.17e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 5.17e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 46879190     28 PNPCENGGICLSGLadDSFSCECPEGF-AGPNC 59
Cdd:smart00179   8 GNPCQNGGTCVNTV--GSYRCECPPGYtDGRNC 38
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 27-58 1.72e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 35.92  E-value: 1.72e-03
                        10        20        30
                ....*....|....*....|....*....|..
gi 46879190  27 NPNPCENGGICLSGLadDSFSCECPEGFAGPN 58
Cdd:cd00053   4 ASNPCSNGGTCVNTP--GSYRCVCPPGYTGDR 33
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 70-107 2.53e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 35.53  E-value: 2.53e-03
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 46879190  70 PNPCHNGGTCEiseayrgDTFIGYVCKCPRGFNG-IHCQ 107
Cdd:cd00053   5 SNPCSNGGTCV-------NTPGSYRCVCPPGYTGdRSCE 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH