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Conserved domains on  [gi|254939534|ref|NP_034351|]
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peptidyl-prolyl cis-trans isomerase FKBP10 isoform 1 precursor [Mus musculus]

Protein Classification

FKBP-type peptidyl-prolyl cis-trans isomerase( domain architecture ID 10446598)

FKBP-type peptidyl-prolyl cis-trans isomerase, with EF-hand calcium binding motifs, acts as a PPIase that accelerates the folding of proteins; similar to Mus musculus peptidyl-prolyl cis-trans isomerase FKBP14

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FKBP_C pfam00254
FKBP-type peptidyl-prolyl cis-trans isomerase;
54-146 6.03e-40

FKBP-type peptidyl-prolyl cis-trans isomerase;


:

Pssm-ID: 459735  Cd Length: 94  Bit Score: 140.41  E-value: 6.03e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939534   54 CPREVQMGDFVRYHYNGTFEDGKKFDSSYDRSTLVAIVVGVGRLITGMDRGLMGMCVNERRRLIVPPHLGYGSIGVAG-L 132
Cdd:pfam00254   1 GPEKAKKGDRVTVHYTGTLEDGTVFDSSYDRGKPFEFTLGSGQVIPGWDEGLVGMKVGEKRKLTIPPELAYGEEGLAGpV 80

                          90
                  ....*....|....
gi 254939534  133 IPPDATLYFDVVLL 146
Cdd:pfam00254  81 IPPNATLVFEVELL 94
FKBP_C pfam00254
FKBP-type peptidyl-prolyl cis-trans isomerase;
166-258 1.46e-37

FKBP-type peptidyl-prolyl cis-trans isomerase;


:

Pssm-ID: 459735  Cd Length: 94  Bit Score: 133.86  E-value: 1.46e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939534  166 CPRMVQNSDFVRYHYNGTLLDGTAFDNSYSRGGTYDTYIGSGWLIKGMDQGLLGMCPGEKRKIIIPPFLAYGEKGY-GTV 244
Cdd:pfam00254   1 GPEKAKKGDRVTVHYTGTLEDGTVFDSSYDRGKPFEFTLGSGQVIPGWDEGLVGMKVGEKRKLTIPPELAYGEEGLaGPV 80

                          90
                  ....*....|....
gi 254939534  245 IPPQASLVFYVLLL 258
Cdd:pfam00254  81 IPPNATLVFEVELL 94
FKBP_C pfam00254
FKBP-type peptidyl-prolyl cis-trans isomerase;
278-370 5.02e-37

FKBP-type peptidyl-prolyl cis-trans isomerase;


:

Pssm-ID: 459735  Cd Length: 94  Bit Score: 132.71  E-value: 5.02e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939534  278 CVRRAVAGDFMRYHYNGSLMDGTLFDSSYSRNHTYNTYVGQGYIIPGMDQGLQGACIGERRRITVPPHLAYGENG-TGDK 356
Cdd:pfam00254   1 GPEKAKKGDRVTVHYTGTLEDGTVFDSSYDRGKPFEFTLGSGQVIPGWDEGLVGMKVGEKRKLTIPPELAYGEEGlAGPV 80

                          90
                  ....*....|....
gi 254939534  357 IPGSAVLIFDVHVI 370
Cdd:pfam00254  81 IPPNATLVFEVELL 94
FKBP_C pfam00254
FKBP-type peptidyl-prolyl cis-trans isomerase;
391-482 9.69e-34

FKBP-type peptidyl-prolyl cis-trans isomerase;


:

Pssm-ID: 459735  Cd Length: 94  Bit Score: 123.46  E-value: 9.69e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939534  391 CNETSKIGDFIRYHYNCSLLDGTRLFSSHDYEAPQEITLGANKVIEGLDRGLQGMCVGERRQLIVPPHLAHGENGARG-- 468
Cdd:pfam00254   1 GPEKAKKGDRVTVHYTGTLEDGTVFDSSYDRGKPFEFTLGSGQVIPGWDEGLVGMKVGEKRKLTIPPELAYGEEGLAGpv 80

                          90
                  ....*....|....
gi 254939534  469 VPGSAVLLFEVELV 482
Cdd:pfam00254  81 IPPNATLVFEVELL 94
FRQ1 super family cl34916
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
482-567 1.68e-07

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG5126:

Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 50.56  E-value: 1.68e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939534 482 VSREDgLPTGYLFVWYQdpstsLFEDMDLNKDGEVPPEEFSSFIKAQVNEGKGRlmpgqdpdkTISDMFQNQDRNQDGKI 561
Cdd:COG5126   22 LERDD-FEALFRRLWAT-----LFSEADTDGDGRISREEFVAGMESLFEATVEP---------FARAAFDLLDTDGDGKI 86


                 ....*.
gi 254939534 562 TAEELK 567
Cdd:COG5126   87 SADEFR 92
 
Name Accession Description Interval E-value
FKBP_C pfam00254
FKBP-type peptidyl-prolyl cis-trans isomerase;
54-146 6.03e-40

FKBP-type peptidyl-prolyl cis-trans isomerase;


Pssm-ID: 459735  Cd Length: 94  Bit Score: 140.41  E-value: 6.03e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939534   54 CPREVQMGDFVRYHYNGTFEDGKKFDSSYDRSTLVAIVVGVGRLITGMDRGLMGMCVNERRRLIVPPHLGYGSIGVAG-L 132
Cdd:pfam00254   1 GPEKAKKGDRVTVHYTGTLEDGTVFDSSYDRGKPFEFTLGSGQVIPGWDEGLVGMKVGEKRKLTIPPELAYGEEGLAGpV 80

                          90
                  ....*....|....
gi 254939534  133 IPPDATLYFDVVLL 146
Cdd:pfam00254  81 IPPNATLVFEVELL 94
FKBP_C pfam00254
FKBP-type peptidyl-prolyl cis-trans isomerase;
166-258 1.46e-37

FKBP-type peptidyl-prolyl cis-trans isomerase;


Pssm-ID: 459735  Cd Length: 94  Bit Score: 133.86  E-value: 1.46e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939534  166 CPRMVQNSDFVRYHYNGTLLDGTAFDNSYSRGGTYDTYIGSGWLIKGMDQGLLGMCPGEKRKIIIPPFLAYGEKGY-GTV 244
Cdd:pfam00254   1 GPEKAKKGDRVTVHYTGTLEDGTVFDSSYDRGKPFEFTLGSGQVIPGWDEGLVGMKVGEKRKLTIPPELAYGEEGLaGPV 80

                          90
                  ....*....|....
gi 254939534  245 IPPQASLVFYVLLL 258
Cdd:pfam00254  81 IPPNATLVFEVELL 94
FKBP_C pfam00254
FKBP-type peptidyl-prolyl cis-trans isomerase;
278-370 5.02e-37

FKBP-type peptidyl-prolyl cis-trans isomerase;


Pssm-ID: 459735  Cd Length: 94  Bit Score: 132.71  E-value: 5.02e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939534  278 CVRRAVAGDFMRYHYNGSLMDGTLFDSSYSRNHTYNTYVGQGYIIPGMDQGLQGACIGERRRITVPPHLAYGENG-TGDK 356
Cdd:pfam00254   1 GPEKAKKGDRVTVHYTGTLEDGTVFDSSYDRGKPFEFTLGSGQVIPGWDEGLVGMKVGEKRKLTIPPELAYGEEGlAGPV 80

                          90
                  ....*....|....
gi 254939534  357 IPGSAVLIFDVHVI 370
Cdd:pfam00254  81 IPPNATLVFEVELL 94
FKBP_C pfam00254
FKBP-type peptidyl-prolyl cis-trans isomerase;
391-482 9.69e-34

FKBP-type peptidyl-prolyl cis-trans isomerase;


Pssm-ID: 459735  Cd Length: 94  Bit Score: 123.46  E-value: 9.69e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939534  391 CNETSKIGDFIRYHYNCSLLDGTRLFSSHDYEAPQEITLGANKVIEGLDRGLQGMCVGERRQLIVPPHLAHGENGARG-- 468
Cdd:pfam00254   1 GPEKAKKGDRVTVHYTGTLEDGTVFDSSYDRGKPFEFTLGSGQVIPGWDEGLVGMKVGEKRKLTIPPELAYGEEGLAGpv 80

                          90
                  ....*....|....
gi 254939534  469 VPGSAVLLFEVELV 482
Cdd:pfam00254  81 IPPNATLVFEVELL 94
FkpA COG0545
FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein ...
 57-148 4.19e-33

FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440311 [Multi-domain]  Cd Length: 104  Bit Score: 122.21  E-value: 4.19e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939534  57 EVQMGDFVRYHYNGTFEDGKKFDSSYDRSTLVAIVVGVGRLITGMDRGLMGMCVNERRRLIVPPHLGYGSIGVAGLIPPD 136
Cdd:COG0545   13 KPKAGDTVTVHYTGTLLDGTVFDSSYDRGEPATFPLGVGQVIPGWDEGLQGMKVGGKRRLVIPPELAYGERGAGGVIPPN 92

                         90
                 ....*....|..
gi 254939534 137 ATLYFDVVLLDV 148
Cdd:COG0545   93 STLVFEVELLDV 104
FkpA COG0545
FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein ...
 282-372 1.43e-30

FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440311 [Multi-domain]  Cd Length: 104  Bit Score: 114.89  E-value: 1.43e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939534 282 AVAGDFMRYHYNGSLMDGTLFDSSYSRNHTYNTYVGQGYIIPGMDQGLQGACIGERRRITVPPHLAYGENGTGDKIPGSA 361
Cdd:COG0545   14 PKAGDTVTVHYTGTLLDGTVFDSSYDRGEPATFPLGVGQVIPGWDEGLQGMKVGGKRRLVIPPELAYGERGAGGVIPPNS 93

                         90
                 ....*....|.
gi 254939534 362 VLIFDVHVIDF 372
Cdd:COG0545   94 TLVFEVELLDV 104
FkpA COG0545
FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein ...
 170-260 1.91e-30

FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440311 [Multi-domain]  Cd Length: 104  Bit Score: 114.51  E-value: 1.91e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939534 170 VQNSDFVRYHYNGTLLDGTAFDNSYSRGGTYDTYIGSGWLIKGMDQGLLGMCPGEKRKIIIPPFLAYGEKGYGTVIPPQA 249
Cdd:COG0545   14 PKAGDTVTVHYTGTLLDGTVFDSSYDRGEPATFPLGVGQVIPGWDEGLQGMKVGGKRRLVIPPELAYGERGAGGVIPPNS 93

                         90
                 ....*....|.
gi 254939534 250 SLVFYVLLLDV 260
Cdd:COG0545   94 TLVFEVELLDV 104
FkpA COG0545
FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein ...
 396-483 2.28e-25

FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440311 [Multi-domain]  Cd Length: 104  Bit Score: 100.26  E-value: 2.28e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939534 396 KIGDFIRYHYNCSLLDGTRLFSSHDYEAPQEITLGANKVIEGLDRGLQGMCVGERRQLIVPPHLAHGENGARGV-PGSAV 474
Cdd:COG0545   15 KAGDTVTVHYTGTLLDGTVFDSSYDRGEPATFPLGVGQVIPGWDEGLQGMKVGGKRRLVIPPELAYGERGAGGViPPNST 94


                 ....*....
gi 254939534 475 LLFEVELVS 483
Cdd:COG0545   95 LVFEVELLD 103
PRK11570 PRK11570
peptidyl-prolyl cis-trans isomerase; Provisional
 173-260 1.09e-15

peptidyl-prolyl cis-trans isomerase; Provisional


Pssm-ID: 183207 [Multi-domain]  Cd Length: 206  Bit Score: 75.99  E-value: 1.09e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939534 173 SDFVRYHYNGTLLDGTAFDNSYSRGGTYDTYIGSgwLIKGMDQGLLGMCPGEKRKIIIPPFLAYGEKGYGTVIPPQASLV 252
Cdd:PRK11570 120 TDRVRVHYTGKLIDGTVFDSSVARGEPAEFPVNG--VIPGWIEALTLMPVGSKWELTIPHELAYGERGAGASIPPFSTLV 197


                 ....*...
gi 254939534 253 FYVLLLDV 260
Cdd:PRK11570 198 FEVELLEI 205
PRK11570 PRK11570
peptidyl-prolyl cis-trans isomerase; Provisional
 286-371 6.78e-14

peptidyl-prolyl cis-trans isomerase; Provisional


Pssm-ID: 183207 [Multi-domain]  Cd Length: 206  Bit Score: 70.60  E-value: 6.78e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939534 286 DFMRYHYNGSLMDGTLFDSSYSRNHTYNTYVGQgyIIPGMDQGLQGACIGERRRITVPPHLAYGENGTGDKIPGSAVLIF 365
Cdd:PRK11570 121 DRVRVHYTGKLIDGTVFDSSVARGEPAEFPVNG--VIPGWIEALTLMPVGSKWELTIPHELAYGERGAGASIPPFSTLVF 198


                 ....*.
gi 254939534 366 DVHVID 371
Cdd:PRK11570 199 EVELLE 204
PRK10902 PRK10902
FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional
 62-148 1.70e-13

FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional


Pssm-ID: 236791 [Multi-domain]  Cd Length: 269  Bit Score: 70.95  E-value: 1.70e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939534  62 DFVRYHYNGTFEDGKKFDSSYDRSTLVAIvvGVGRLITGMDRGLMGMCVNERRRLIVPPHLGYGSIGVAGlIPPDATLYF 141
Cdd:PRK10902 165 DTVVVNYKGTLIDGKEFDNSYTRGEPLSF--RLDGVIPGWTEGLKNIKKGGKIKLVIPPELAYGKAGVPG-IPANSTLVF 241


                 ....*..
gi 254939534 142 DVVLLDV 148
Cdd:PRK10902 242 DVELLDV 248
PRK10902 PRK10902
FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional
 389-483 3.58e-10

FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional


Pssm-ID: 236791 [Multi-domain]  Cd Length: 269  Bit Score: 60.93  E-value: 3.58e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939534 389 ENCNETSKIGDFIRYHYNCSLLDGTRLFSSHDYEAPQEITLgaNKVIEGLDRGLQGMCVGERRQLIVPPHLAHGENGARG 468
Cdd:PRK10902 155 EGTGEAPKDSDTVVVNYKGTLIDGKEFDNSYTRGEPLSFRL--DGVIPGWTEGLKNIKKGGKIKLVIPPELAYGKAGVPG 232

                         90
                 ....*....|....*
gi 254939534 469 VPGSAVLLFEVELVS 483
Cdd:PRK10902 233 IPANSTLVFDVELLD 247
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
482-567 1.68e-07

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 50.56  E-value: 1.68e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939534 482 VSREDgLPTGYLFVWYQdpstsLFEDMDLNKDGEVPPEEFSSFIKAQVNEGKGRlmpgqdpdkTISDMFQNQDRNQDGKI 561
Cdd:COG5126   22 LERDD-FEALFRRLWAT-----LFSEADTDGDGRISREEFVAGMESLFEATVEP---------FARAAFDLLDTDGDGKI 86


                 ....*.
gi 254939534 562 TAEELK 567
Cdd:COG5126   87 SADEFR 92
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 505-566 1.08e-06

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 46.00  E-value: 1.08e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 254939534 505 FEDMDLNKDGEVPPEEFSSFIKAQvnegkGRLMPGQDPDKTISDMfqnqDRNQDGKITAEEL 566
Cdd:cd00051    6 FRLFDKDGDGTISADELKAALKSL-----GEGLSEEEIDEMIREV----DKDGDGKIDFEEF 58
EF-hand_7 pfam13499
EF-hand domain pair;
504-567 5.91e-04

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 38.39  E-value: 5.91e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 254939534  504 LFEDMDLNKDGEVPPEEFSSFIKaqvnegkgRLMPGQDPDKT-ISDMFQNQDRNQDGKITAEELK 567
Cdd:pfam13499   7 AFKLLDSDGDGYLDVEELKKLLR--------KLEEGEPLSDEeVEELFKEFDLDKDGRISFEEFL 63
PLN02964 PLN02964
phosphatidylserine decarboxylase
 508-566 5.27e-03

phosphatidylserine decarboxylase


Pssm-ID: 215520 [Multi-domain]  Cd Length: 644  Bit Score: 39.84  E-value: 5.27e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 254939534 508 MDLNKDGEVPPEEFSSFIKAQVNegkgrlmpgQDPDKTISDMFQNQDRNQDGKITAEEL 566
Cdd:PLN02964 188 VDYDEDGQLSFSEFSDLIKAFGN---------LVAANKKEELFKAADLNGDGVVTIDEL 237
 
Name Accession Description Interval E-value
FKBP_C pfam00254
FKBP-type peptidyl-prolyl cis-trans isomerase;
54-146 6.03e-40

FKBP-type peptidyl-prolyl cis-trans isomerase;


Pssm-ID: 459735  Cd Length: 94  Bit Score: 140.41  E-value: 6.03e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939534   54 CPREVQMGDFVRYHYNGTFEDGKKFDSSYDRSTLVAIVVGVGRLITGMDRGLMGMCVNERRRLIVPPHLGYGSIGVAG-L 132
Cdd:pfam00254   1 GPEKAKKGDRVTVHYTGTLEDGTVFDSSYDRGKPFEFTLGSGQVIPGWDEGLVGMKVGEKRKLTIPPELAYGEEGLAGpV 80

                          90
                  ....*....|....
gi 254939534  133 IPPDATLYFDVVLL 146
Cdd:pfam00254  81 IPPNATLVFEVELL 94
FKBP_C pfam00254
FKBP-type peptidyl-prolyl cis-trans isomerase;
166-258 1.46e-37

FKBP-type peptidyl-prolyl cis-trans isomerase;


Pssm-ID: 459735  Cd Length: 94  Bit Score: 133.86  E-value: 1.46e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939534  166 CPRMVQNSDFVRYHYNGTLLDGTAFDNSYSRGGTYDTYIGSGWLIKGMDQGLLGMCPGEKRKIIIPPFLAYGEKGY-GTV 244
Cdd:pfam00254   1 GPEKAKKGDRVTVHYTGTLEDGTVFDSSYDRGKPFEFTLGSGQVIPGWDEGLVGMKVGEKRKLTIPPELAYGEEGLaGPV 80

                          90
                  ....*....|....
gi 254939534  245 IPPQASLVFYVLLL 258
Cdd:pfam00254  81 IPPNATLVFEVELL 94
FKBP_C pfam00254
FKBP-type peptidyl-prolyl cis-trans isomerase;
278-370 5.02e-37

FKBP-type peptidyl-prolyl cis-trans isomerase;


Pssm-ID: 459735  Cd Length: 94  Bit Score: 132.71  E-value: 5.02e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939534  278 CVRRAVAGDFMRYHYNGSLMDGTLFDSSYSRNHTYNTYVGQGYIIPGMDQGLQGACIGERRRITVPPHLAYGENG-TGDK 356
Cdd:pfam00254   1 GPEKAKKGDRVTVHYTGTLEDGTVFDSSYDRGKPFEFTLGSGQVIPGWDEGLVGMKVGEKRKLTIPPELAYGEEGlAGPV 80

                          90
                  ....*....|....
gi 254939534  357 IPGSAVLIFDVHVI 370
Cdd:pfam00254  81 IPPNATLVFEVELL 94
FKBP_C pfam00254
FKBP-type peptidyl-prolyl cis-trans isomerase;
391-482 9.69e-34

FKBP-type peptidyl-prolyl cis-trans isomerase;


Pssm-ID: 459735  Cd Length: 94  Bit Score: 123.46  E-value: 9.69e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939534  391 CNETSKIGDFIRYHYNCSLLDGTRLFSSHDYEAPQEITLGANKVIEGLDRGLQGMCVGERRQLIVPPHLAHGENGARG-- 468
Cdd:pfam00254   1 GPEKAKKGDRVTVHYTGTLEDGTVFDSSYDRGKPFEFTLGSGQVIPGWDEGLVGMKVGEKRKLTIPPELAYGEEGLAGpv 80

                          90
                  ....*....|....
gi 254939534  469 VPGSAVLLFEVELV 482
Cdd:pfam00254  81 IPPNATLVFEVELL 94
FkpA COG0545
FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein ...
 57-148 4.19e-33

FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440311 [Multi-domain]  Cd Length: 104  Bit Score: 122.21  E-value: 4.19e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939534  57 EVQMGDFVRYHYNGTFEDGKKFDSSYDRSTLVAIVVGVGRLITGMDRGLMGMCVNERRRLIVPPHLGYGSIGVAGLIPPD 136
Cdd:COG0545   13 KPKAGDTVTVHYTGTLLDGTVFDSSYDRGEPATFPLGVGQVIPGWDEGLQGMKVGGKRRLVIPPELAYGERGAGGVIPPN 92

                         90
                 ....*....|..
gi 254939534 137 ATLYFDVVLLDV 148
Cdd:COG0545   93 STLVFEVELLDV 104
FkpA COG0545
FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein ...
 282-372 1.43e-30

FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440311 [Multi-domain]  Cd Length: 104  Bit Score: 114.89  E-value: 1.43e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939534 282 AVAGDFMRYHYNGSLMDGTLFDSSYSRNHTYNTYVGQGYIIPGMDQGLQGACIGERRRITVPPHLAYGENGTGDKIPGSA 361
Cdd:COG0545   14 PKAGDTVTVHYTGTLLDGTVFDSSYDRGEPATFPLGVGQVIPGWDEGLQGMKVGGKRRLVIPPELAYGERGAGGVIPPNS 93

                         90
                 ....*....|.
gi 254939534 362 VLIFDVHVIDF 372
Cdd:COG0545   94 TLVFEVELLDV 104
FkpA COG0545
FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein ...
 170-260 1.91e-30

FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440311 [Multi-domain]  Cd Length: 104  Bit Score: 114.51  E-value: 1.91e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939534 170 VQNSDFVRYHYNGTLLDGTAFDNSYSRGGTYDTYIGSGWLIKGMDQGLLGMCPGEKRKIIIPPFLAYGEKGYGTVIPPQA 249
Cdd:COG0545   14 PKAGDTVTVHYTGTLLDGTVFDSSYDRGEPATFPLGVGQVIPGWDEGLQGMKVGGKRRLVIPPELAYGERGAGGVIPPNS 93

                         90
                 ....*....|.
gi 254939534 250 SLVFYVLLLDV 260
Cdd:COG0545   94 TLVFEVELLDV 104
FkpA COG0545
FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein ...
 396-483 2.28e-25

FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440311 [Multi-domain]  Cd Length: 104  Bit Score: 100.26  E-value: 2.28e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939534 396 KIGDFIRYHYNCSLLDGTRLFSSHDYEAPQEITLGANKVIEGLDRGLQGMCVGERRQLIVPPHLAHGENGARGV-PGSAV 474
Cdd:COG0545   15 KAGDTVTVHYTGTLLDGTVFDSSYDRGEPATFPLGVGQVIPGWDEGLQGMKVGGKRRLVIPPELAYGERGAGGViPPNST 94


                 ....*....
gi 254939534 475 LLFEVELVS 483
Cdd:COG0545   95 LVFEVELLD 103
PRK11570 PRK11570
peptidyl-prolyl cis-trans isomerase; Provisional
 173-260 1.09e-15

peptidyl-prolyl cis-trans isomerase; Provisional


Pssm-ID: 183207 [Multi-domain]  Cd Length: 206  Bit Score: 75.99  E-value: 1.09e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939534 173 SDFVRYHYNGTLLDGTAFDNSYSRGGTYDTYIGSgwLIKGMDQGLLGMCPGEKRKIIIPPFLAYGEKGYGTVIPPQASLV 252
Cdd:PRK11570 120 TDRVRVHYTGKLIDGTVFDSSVARGEPAEFPVNG--VIPGWIEALTLMPVGSKWELTIPHELAYGERGAGASIPPFSTLV 197


                 ....*...
gi 254939534 253 FYVLLLDV 260
Cdd:PRK11570 198 FEVELLEI 205
PRK10902 PRK10902
FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional
 172-260 5.17e-15

FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional


Pssm-ID: 236791 [Multi-domain]  Cd Length: 269  Bit Score: 75.57  E-value: 5.17e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939534 172 NSDFVRYHYNGTLLDGTAFDNSYSRGGTYDTYIGSgwLIKGMDQGLLGMCPGEKRKIIIPPFLAYGEKGYGTvIPPQASL 251
Cdd:PRK10902 163 DSDTVVVNYKGTLIDGKEFDNSYTRGEPLSFRLDG--VIPGWTEGLKNIKKGGKIKLVIPPELAYGKAGVPG-IPANSTL 239


                 ....*....
gi 254939534 252 VFYVLLLDV 260
Cdd:PRK10902 240 VFDVELLDV 248
PRK11570 PRK11570
peptidyl-prolyl cis-trans isomerase; Provisional
 286-371 6.78e-14

peptidyl-prolyl cis-trans isomerase; Provisional


Pssm-ID: 183207 [Multi-domain]  Cd Length: 206  Bit Score: 70.60  E-value: 6.78e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939534 286 DFMRYHYNGSLMDGTLFDSSYSRNHTYNTYVGQgyIIPGMDQGLQGACIGERRRITVPPHLAYGENGTGDKIPGSAVLIF 365
Cdd:PRK11570 121 DRVRVHYTGKLIDGTVFDSSVARGEPAEFPVNG--VIPGWIEALTLMPVGSKWELTIPHELAYGERGAGASIPPFSTLVF 198


                 ....*.
gi 254939534 366 DVHVID 371
Cdd:PRK11570 199 EVELLE 204
PRK10902 PRK10902
FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional
 62-148 1.70e-13

FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional


Pssm-ID: 236791 [Multi-domain]  Cd Length: 269  Bit Score: 70.95  E-value: 1.70e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939534  62 DFVRYHYNGTFEDGKKFDSSYDRSTLVAIvvGVGRLITGMDRGLMGMCVNERRRLIVPPHLGYGSIGVAGlIPPDATLYF 141
Cdd:PRK10902 165 DTVVVNYKGTLIDGKEFDNSYTRGEPLSF--RLDGVIPGWTEGLKNIKKGGKIKLVIPPELAYGKAGVPG-IPANSTLVF 241


                 ....*..
gi 254939534 142 DVVLLDV 148
Cdd:PRK10902 242 DVELLDV 248
SlpA COG1047
Peptidyl-prolyl cis-trans isomerase, FKBP type [Posttranslational modification, protein ...
 170-255 3.44e-13

Peptidyl-prolyl cis-trans isomerase, FKBP type [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440668 [Multi-domain]  Cd Length: 138  Bit Score: 66.66  E-value: 3.44e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939534 170 VQNSDFVRYHYNGTLLDGTAFDNSysRGGTYDTYI-GSGWLIKGMDQGLLGMCPGEKRKIIIPPflaygEKGYGtviPPQ 248
Cdd:COG1047    1 IEKGDVVTLHYTLKLEDGEVFDST--FEGEPLEFLhGAGQLIPGLEEALEGMEVGDKKTVTLPP-----EEAYG---ERD 70


                 ....*..
gi 254939534 249 ASLVFYV 255
Cdd:COG1047   71 PELVQTV 77
PRK10902 PRK10902
FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional
 292-371 1.14e-12

FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional


Pssm-ID: 236791 [Multi-domain]  Cd Length: 269  Bit Score: 68.25  E-value: 1.14e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939534 292 YNGSLMDGTLFDSSYSRNHTYnTYVGQGyIIPGMDQGLQGACIGERRRITVPPHLAYGENGTgDKIPGSAVLIFDVHVID 371
Cdd:PRK10902 171 YKGTLIDGKEFDNSYTRGEPL-SFRLDG-VIPGWTEGLKNIKKGGKIKLVIPPELAYGKAGV-PGIPANSTLVFDVELLD 247
SlpA COG1047
Peptidyl-prolyl cis-trans isomerase, FKBP type [Posttranslational modification, protein ...
 58-125 2.43e-12

Peptidyl-prolyl cis-trans isomerase, FKBP type [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440668 [Multi-domain]  Cd Length: 138  Bit Score: 64.35  E-value: 2.43e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 254939534  58 VQMGDFVRYHYNGTFEDGKKFDSSYDRSTLVaIVVGVGRLITGMDRGLMGMCVNERRRLIVPPHLGYG 125
Cdd:COG1047    1 IEKGDVVTLHYTLKLEDGEVFDSTFEGEPLE-FLHGAGQLIPGLEEALEGMEVGDKKTVTLPPEEAYG 67
SlpA COG1047
Peptidyl-prolyl cis-trans isomerase, FKBP type [Posttranslational modification, protein ...
 284-350 2.38e-11

Peptidyl-prolyl cis-trans isomerase, FKBP type [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440668 [Multi-domain]  Cd Length: 138  Bit Score: 61.66  E-value: 2.38e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 254939534 284 AGDFMRYHYNGSLMDGTLFDSSYSRN-HTYNtyVGQGYIIPGMDQGLQGACIGERRRITVPPHLAYGE 350
Cdd:COG1047    3 KGDVVTLHYTLKLEDGEVFDSTFEGEpLEFL--HGAGQLIPGLEEALEGMEVGDKKTVTLPPEEAYGE 68
PRK11570 PRK11570
peptidyl-prolyl cis-trans isomerase; Provisional
 62-148 4.29e-11

peptidyl-prolyl cis-trans isomerase; Provisional


Pssm-ID: 183207 [Multi-domain]  Cd Length: 206  Bit Score: 62.51  E-value: 4.29e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939534  62 DFVRYHYNGTFEDGKKFDSSYDRSTLVAI-VVGVgrlITGMDRGLMGMCVNERRRLIVPPHLGYGSIGVAGLIPPDATLY 140
Cdd:PRK11570 121 DRVRVHYTGKLIDGTVFDSSVARGEPAEFpVNGV---IPGWIEALTLMPVGSKWELTIPHELAYGERGAGASIPPFSTLV 197


                 ....*...
gi 254939534 141 FDVVLLDV 148
Cdd:PRK11570 198 FEVELLEI 205
PRK10902 PRK10902
FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional
 389-483 3.58e-10

FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional


Pssm-ID: 236791 [Multi-domain]  Cd Length: 269  Bit Score: 60.93  E-value: 3.58e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939534 389 ENCNETSKIGDFIRYHYNCSLLDGTRLFSSHDYEAPQEITLgaNKVIEGLDRGLQGMCVGERRQLIVPPHLAHGENGARG 468
Cdd:PRK10902 155 EGTGEAPKDSDTVVVNYKGTLIDGKEFDNSYTRGEPLSFRL--DGVIPGWTEGLKNIKKGGKIKLVIPPELAYGKAGVPG 232

                         90
                 ....*....|....*
gi 254939534 469 VPGSAVLLFEVELVS 483
Cdd:PRK10902 233 IPANSTLVFDVELLD 247
PRK11570 PRK11570
peptidyl-prolyl cis-trans isomerase; Provisional
 399-482 7.95e-10

peptidyl-prolyl cis-trans isomerase; Provisional


Pssm-ID: 183207 [Multi-domain]  Cd Length: 206  Bit Score: 59.04  E-value: 7.95e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939534 399 DFIRYHYNCSLLDGTRLFSSHDYEAPQEITLgaNKVIEGLDRGLQGMCVGERRQLIVPPHLAHGENGA-RGVPGSAVLLF 477
Cdd:PRK11570 121 DRVRVHYTGKLIDGTVFDSSVARGEPAEFPV--NGVIPGWIEALTLMPVGSKWELTIPHELAYGERGAgASIPPFSTLVF 198


                 ....*
gi 254939534 478 EVELV 482
Cdd:PRK11570 199 EVELL 203
SlpA COG1047
Peptidyl-prolyl cis-trans isomerase, FKBP type [Posttranslational modification, protein ...
 398-463 2.75e-08

Peptidyl-prolyl cis-trans isomerase, FKBP type [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440668 [Multi-domain]  Cd Length: 138  Bit Score: 52.80  E-value: 2.75e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 254939534 398 GDFIRYHYNCSLLDGTrLFSSHDYEAPQEITLGANKVIEGLDRGLQGMCVGERRQLIVPPHLAHGE 463
Cdd:COG1047    4 GDVVTLHYTLKLEDGE-VFDSTFEGEPLEFLHGAGQLIPGLEEALEGMEVGDKKTVTLPPEEAYGE 68
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
482-567 1.68e-07

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 50.56  E-value: 1.68e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939534 482 VSREDgLPTGYLFVWYQdpstsLFEDMDLNKDGEVPPEEFSSFIKAQVNEGKGRlmpgqdpdkTISDMFQNQDRNQDGKI 561
Cdd:COG5126   22 LERDD-FEALFRRLWAT-----LFSEADTDGDGRISREEFVAGMESLFEATVEP---------FARAAFDLLDTDGDGKI 86


                 ....*.
gi 254939534 562 TAEELK 567
Cdd:COG5126   87 SADEFR 92
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 505-566 1.08e-06

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 46.00  E-value: 1.08e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 254939534 505 FEDMDLNKDGEVPPEEFSSFIKAQvnegkGRLMPGQDPDKTISDMfqnqDRNQDGKITAEEL 566
Cdd:cd00051    6 FRLFDKDGDGTISADELKAALKSL-----GEGLSEEEIDEMIREV----DKDGDGKIDFEEF 58
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
503-567 1.16e-05

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 45.17  E-value: 1.16e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 254939534 503 SLFEDMDLNKDGEVPPEEFSSFIKAqvnegkgrlmpGQDPDKTISDMFQNQDRNQDGKITAEELK 567
Cdd:COG5126   73 AAFDLLDTDGDGKISADEFRRLLTA-----------LGVSEEEADELFARLDTDGDGKISFEEFV 126
PRK15095 PRK15095
FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional
 170-238 3.63e-04

FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional


Pssm-ID: 237908 [Multi-domain]  Cd Length: 156  Bit Score: 41.23  E-value: 3.63e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 254939534 170 VQNSDFVRYHYNGTLLDGTAFDNSYSRGGTYDTYIGSGWLIKGMDQGLLGMCPGEKRKIIIPPFLAYGE 238
Cdd:PRK15095   5 VQSNSAVLVHFTLKLDDGSTAESTRNNGKPALFRLGDGSLSEGLEQQLLGLKVGDKKTFSLEPEAAFGV 73
EF-hand_7 pfam13499
EF-hand domain pair;
504-567 5.91e-04

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 38.39  E-value: 5.91e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 254939534  504 LFEDMDLNKDGEVPPEEFSSFIKaqvnegkgRLMPGQDPDKT-ISDMFQNQDRNQDGKITAEELK 567
Cdd:pfam13499   7 AFKLLDSDGDGYLDVEELKKLLR--------KLEEGEPLSDEeVEELFKEFDLDKDGRISFEEFL 63
PLN02964 PLN02964
phosphatidylserine decarboxylase
 508-566 5.27e-03

phosphatidylserine decarboxylase


Pssm-ID: 215520 [Multi-domain]  Cd Length: 644  Bit Score: 39.84  E-value: 5.27e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 254939534 508 MDLNKDGEVPPEEFSSFIKAQVNegkgrlmpgQDPDKTISDMFQNQDRNQDGKITAEEL 566
Cdd:PLN02964 188 VDYDEDGQLSFSEFSDLIKAFGN---------LVAANKKEELFKAADLNGDGVVTIDEL 237
Tig COG0544
FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) [Posttranslational modification, ...
 168-228 6.41e-03

FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440310 [Multi-domain]  Cd Length: 424  Bit Score: 39.34  E-value: 6.41e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 254939534 168 RMVQNSDFVRYHYNGTLlDGTAFDnsysrGGTYDTY---IGSGWLIKGMDQGLLGMCPGEKRKI 228
Cdd:COG0544  156 RAAEEGDRVTIDFEGTI-DGEEFE-----GGKAEDYsleLGSGSFIPGFEEQLVGMKAGEEKTF 213
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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