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Conserved domains on  [gi|114326554|ref|NP_034706|]
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integrin alpha-4 precursor [Mus musculus]

Protein Classification

integrin alpha( domain architecture ID 12192630)

integrin alpha forms a heterodimer with integrin beta to mediate cell-extracellular matrix and cell-cell interactions; integrin alpha is a component of integrin, a cell adhesion molecule that mediates cell-extracellular matrix and cell-cell interactions

CATH:  2.130.10.130|2.60.40.1510|2.60.40.1530|2.60.40.1460
Gene Ontology:  GO:0007155|GO:0008305|GO:0005178|GO:0046872
PubMed:  3028640|2199285|12297042|12826403|14689578|12361595|12234368
SCOP:  4003137

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 464-902 6.10e-118

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


:

Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 369.73  E-value: 6.10e-118
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326554   464 RPVVIVEASLSH-PESVNRTKFDCTENGLPSVCMHLTLCFSYKGKEVP-GYIVLFYNVSLDVHRKAESPSRFYFFSNGTS 541
Cdd:pfam08441    1 RPVVSVSASLQVePNSINPEKKNCTLTGTPVSCFTVRACFSYTGKPIPnPSLVLNYELELDRQKKKGLPPRVLFLDSQQP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326554   542 DVITGSIRVSSSGEKCRTHQAFMRKDVRDILTPIHVEATYHLghhVITKRNTEEFPPLQPILQQkKEKDVIRKMINFARF 621
Cdd:pfam08441   81 SLTGTLVLLSQGRKVCRTTKAYLRDEFRDKLSPIVISLNYSL---RVDPRAPSDLPGLKPILDQ-NQPSTVQEQANFLKD 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326554   622 CAYEN-CSADLQVSAKVGFLkpyENKTYLAVGSMKTIMLNVSLFNAGDDAYETTLNVQLPTGLYFIKILDLE-EKQINCE 699
Cdd:pfam08441  157 CGEDNvCVPDLQLSAKFDSR---ESDEPLLLGDDNDLALEITVTNLGEDAYEAELYVTLPPGLDYSGVRREGsEKQLSCT 233

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326554   700 VTESSGIVKLACSLGYIYVdRLSRIDISFLLDVSSLSRAHEDLSISVHASCENEgelDQVRDNRVTLTIPLRYEVMLTVH 779
Cdd:pfam08441  234 AKKENSTRQVVCDLGNPMK-RGTQVTFGLRFSVSGLELSTEELSFDLQIRSTNE---QNSNSNPVSLKVPVVAEAQLSLS 309

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326554   780 GLVNPTSFVYG-----SSEENEPETCMAEKLNLTFHVINTGISMAPNVSVKIMVPNSFLPQDDkLFNVLDVQTT-TGQCH 853
Cdd:pfam08441  310 GVSKPDQVVGGsvkgeSAMKPRSEEDIGPLVEHTYEVINNGPSTVSGASLEISWPYELSNGKW-LLYLLDVQGQgKGECS 388

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 114326554   854 FKHYGRECTFAQQKGIAGTLTDIVKFLSKTDKRLLYCMKADQ------------HCLDFLC 902
Cdd:pfam08441  389 PQNEINPLNLTQSLESSKPLRTSRVHHVVKRRDVLKSEKATQtasvllscdsgaRCVVIRC 449
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 366-418 6.12e-15

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 70.10  E-value: 6.12e-15
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 114326554    366 ARFGESIANLGDIDNDGFEDIAIGAPQEDDLR--GAVYIYNGRVDGISSTYSQRI 418
Cdd:smart00191    3 SYFGYSVAGVGDVNGDGYPDLLVGAPRANDAGetGAVYVYFGSSGGGNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 303-351 4.20e-12

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 62.01  E-value: 4.20e-12
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 114326554    303 GSYFGASVCAV-DLNADGFSDLLVGAPMQSTIREEGRVFVYINSGMGAVM 351
Cdd:smart00191    2 GSYFGYSVAGVgDVNGDGYPDLLVGAPRANDAGETGAVYVYFGSSGGGNS 51
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 429-479 2.34e-05

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 42.75  E-value: 2.34e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|.
gi 114326554    429 MFGQSISGQIDADNNGYVDVAVGAFQSDSAVLLRTRPVVIVEASLSHPESV 479
Cdd:smart00191    4 YFGYSVAGVGDVNGDGYPDLLVGAPRANDAGETGAVYVYFGSSGGGNSIPL 54
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 48-105 7.38e-04

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 38.51  E-value: 7.38e-04
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 114326554     48 SGTLFGYSVVLHSHG---SKRWLIVGAPTASWLsnasvVNPGAIYRCGIRKNpNQTCEQLQ 105
Cdd:smart00191    1 PGSYFGYSVAGVGDVngdGYPDLLVGAPRANDA-----GETGAVYVYFGSSG-GGNSIPLQ 55
 
Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 464-902 6.10e-118

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 369.73  E-value: 6.10e-118
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326554   464 RPVVIVEASLSH-PESVNRTKFDCTENGLPSVCMHLTLCFSYKGKEVP-GYIVLFYNVSLDVHRKAESPSRFYFFSNGTS 541
Cdd:pfam08441    1 RPVVSVSASLQVePNSINPEKKNCTLTGTPVSCFTVRACFSYTGKPIPnPSLVLNYELELDRQKKKGLPPRVLFLDSQQP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326554   542 DVITGSIRVSSSGEKCRTHQAFMRKDVRDILTPIHVEATYHLghhVITKRNTEEFPPLQPILQQkKEKDVIRKMINFARF 621
Cdd:pfam08441   81 SLTGTLVLLSQGRKVCRTTKAYLRDEFRDKLSPIVISLNYSL---RVDPRAPSDLPGLKPILDQ-NQPSTVQEQANFLKD 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326554   622 CAYEN-CSADLQVSAKVGFLkpyENKTYLAVGSMKTIMLNVSLFNAGDDAYETTLNVQLPTGLYFIKILDLE-EKQINCE 699
Cdd:pfam08441  157 CGEDNvCVPDLQLSAKFDSR---ESDEPLLLGDDNDLALEITVTNLGEDAYEAELYVTLPPGLDYSGVRREGsEKQLSCT 233

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326554   700 VTESSGIVKLACSLGYIYVdRLSRIDISFLLDVSSLSRAHEDLSISVHASCENEgelDQVRDNRVTLTIPLRYEVMLTVH 779
Cdd:pfam08441  234 AKKENSTRQVVCDLGNPMK-RGTQVTFGLRFSVSGLELSTEELSFDLQIRSTNE---QNSNSNPVSLKVPVVAEAQLSLS 309

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326554   780 GLVNPTSFVYG-----SSEENEPETCMAEKLNLTFHVINTGISMAPNVSVKIMVPNSFLPQDDkLFNVLDVQTT-TGQCH 853
Cdd:pfam08441  310 GVSKPDQVVGGsvkgeSAMKPRSEEDIGPLVEHTYEVINNGPSTVSGASLEISWPYELSNGKW-LLYLLDVQGQgKGECS 388

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 114326554   854 FKHYGRECTFAQQKGIAGTLTDIVKFLSKTDKRLLYCMKADQ------------HCLDFLC 902
Cdd:pfam08441  389 PQNEINPLNLTQSLESSKPLRTSRVHHVVKRRDVLKSEKATQtasvllscdsgaRCVVIRC 449
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 366-418 6.12e-15

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 70.10  E-value: 6.12e-15
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 114326554    366 ARFGESIANLGDIDNDGFEDIAIGAPQEDDLR--GAVYIYNGRVDGISSTYSQRI 418
Cdd:smart00191    3 SYFGYSVAGVGDVNGDGYPDLLVGAPRANDAGetGAVYVYFGSSGGGNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 303-351 4.20e-12

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 62.01  E-value: 4.20e-12
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 114326554    303 GSYFGASVCAV-DLNADGFSDLLVGAPMQSTIREEGRVFVYINSGMGAVM 351
Cdd:smart00191    2 GSYFGYSVAGVgDVNGDGYPDLLVGAPRANDAGETGAVYVYFGSSGGGNS 51
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 368-403 1.24e-08

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 51.36  E-value: 1.24e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 114326554   368 FGESIAnLGDIDNDGFEDIAIGAPQEDDLR-GAVYIY 403
Cdd:pfam01839    1 FGYSVA-VGDLNGDGYADLAVGAPGEGGAGaGAVYVL 36
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 306-342 1.46e-08

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 51.36  E-value: 1.46e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 114326554   306 FGASVCAVDLNADGFSDLLVGAPmQSTIREEGRVFVY 342
Cdd:pfam01839    1 FGYSVAVGDLNGDGYADLAVGAP-GEGGAGAGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 429-479 2.34e-05

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 42.75  E-value: 2.34e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|.
gi 114326554    429 MFGQSISGQIDADNNGYVDVAVGAFQSDSAVLLRTRPVVIVEASLSHPESV 479
Cdd:smart00191    4 YFGYSVAGVGDVNGDGYPDLLVGAPRANDAGETGAVYVYFGSSGGGNSIPL 54
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 48-105 7.38e-04

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 38.51  E-value: 7.38e-04
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 114326554     48 SGTLFGYSVVLHSHG---SKRWLIVGAPTASWLsnasvVNPGAIYRCGIRKNpNQTCEQLQ 105
Cdd:smart00191    1 PGSYFGYSVAGVGDVngdGYPDLLVGAPRANDA-----GETGAVYVYFGSSG-GGNSIPLQ 55
 
Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 464-902 6.10e-118

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 369.73  E-value: 6.10e-118
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326554   464 RPVVIVEASLSH-PESVNRTKFDCTENGLPSVCMHLTLCFSYKGKEVP-GYIVLFYNVSLDVHRKAESPSRFYFFSNGTS 541
Cdd:pfam08441    1 RPVVSVSASLQVePNSINPEKKNCTLTGTPVSCFTVRACFSYTGKPIPnPSLVLNYELELDRQKKKGLPPRVLFLDSQQP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326554   542 DVITGSIRVSSSGEKCRTHQAFMRKDVRDILTPIHVEATYHLghhVITKRNTEEFPPLQPILQQkKEKDVIRKMINFARF 621
Cdd:pfam08441   81 SLTGTLVLLSQGRKVCRTTKAYLRDEFRDKLSPIVISLNYSL---RVDPRAPSDLPGLKPILDQ-NQPSTVQEQANFLKD 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326554   622 CAYEN-CSADLQVSAKVGFLkpyENKTYLAVGSMKTIMLNVSLFNAGDDAYETTLNVQLPTGLYFIKILDLE-EKQINCE 699
Cdd:pfam08441  157 CGEDNvCVPDLQLSAKFDSR---ESDEPLLLGDDNDLALEITVTNLGEDAYEAELYVTLPPGLDYSGVRREGsEKQLSCT 233

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326554   700 VTESSGIVKLACSLGYIYVdRLSRIDISFLLDVSSLSRAHEDLSISVHASCENEgelDQVRDNRVTLTIPLRYEVMLTVH 779
Cdd:pfam08441  234 AKKENSTRQVVCDLGNPMK-RGTQVTFGLRFSVSGLELSTEELSFDLQIRSTNE---QNSNSNPVSLKVPVVAEAQLSLS 309

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326554   780 GLVNPTSFVYG-----SSEENEPETCMAEKLNLTFHVINTGISMAPNVSVKIMVPNSFLPQDDkLFNVLDVQTT-TGQCH 853
Cdd:pfam08441  310 GVSKPDQVVGGsvkgeSAMKPRSEEDIGPLVEHTYEVINNGPSTVSGASLEISWPYELSNGKW-LLYLLDVQGQgKGECS 388

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 114326554   854 FKHYGRECTFAQQKGIAGTLTDIVKFLSKTDKRLLYCMKADQ------------HCLDFLC 902
Cdd:pfam08441  389 PQNEINPLNLTQSLESSKPLRTSRVHHVVKRRDVLKSEKATQtasvllscdsgaRCVVIRC 449
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 366-418 6.12e-15

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 70.10  E-value: 6.12e-15
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 114326554    366 ARFGESIANLGDIDNDGFEDIAIGAPQEDDLR--GAVYIYNGRVDGISSTYSQRI 418
Cdd:smart00191    3 SYFGYSVAGVGDVNGDGYPDLLVGAPRANDAGetGAVYVYFGSSGGGNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 303-351 4.20e-12

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 62.01  E-value: 4.20e-12
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 114326554    303 GSYFGASVCAV-DLNADGFSDLLVGAPMQSTIREEGRVFVYINSGMGAVM 351
Cdd:smart00191    2 GSYFGYSVAGVgDVNGDGYPDLLVGAPRANDAGETGAVYVYFGSSGGGNS 51
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 368-403 1.24e-08

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 51.36  E-value: 1.24e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 114326554   368 FGESIAnLGDIDNDGFEDIAIGAPQEDDLR-GAVYIY 403
Cdd:pfam01839    1 FGYSVA-VGDLNGDGYADLAVGAPGEGGAGaGAVYVL 36
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 306-342 1.46e-08

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 51.36  E-value: 1.46e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 114326554   306 FGASVCAVDLNADGFSDLLVGAPmQSTIREEGRVFVY 342
Cdd:pfam01839    1 FGYSVAVGDLNGDGYADLAVGAP-GEGGAGAGAVYVL 36
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 314-388 1.53e-05

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 43.37  E-value: 1.53e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 114326554   314 DLNADGFSDLLVGapmqstirEEGRVFVYINSGMGAvMVEMERVLVGsdkyAARFGESIAnLGDIDNDGFEDIAI 388
Cdd:pfam13517    1 DLDGDGKLDLVVA--------NDGGLRLYLNNGDGT-FTFITSVSLG----GGGGGLSVA-VGDLDGDGRLDLLV 61
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 429-479 2.34e-05

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 42.75  E-value: 2.34e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|.
gi 114326554    429 MFGQSISGQIDADNNGYVDVAVGAFQSDSAVLLRTRPVVIVEASLSHPESV 479
Cdd:smart00191    4 YFGYSVAGVGDVNGDGYPDLLVGAPRANDAGETGAVYVYFGSSGGGNSIPL 54
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 48-105 7.38e-04

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 38.51  E-value: 7.38e-04
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 114326554     48 SGTLFGYSVVLHSHG---SKRWLIVGAPTASWLsnasvVNPGAIYRCGIRKNpNQTCEQLQ 105
Cdd:smart00191    1 PGSYFGYSVAGVGDVngdGYPDLLVGAPRANDA-----GETGAVYVYFGSSG-GGNSIPLQ 55
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 377-450 6.96e-03

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 36.05  E-value: 6.96e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 114326554   377 DIDNDGFEDIAIGApqeddlRGAVYIYNGRVDGISSTYSQRIegqqisksLRMFGQSISGQI-DADNNGYVDVAV 450
Cdd:pfam13517    1 DLDGDGKLDLVVAN------DGGLRLYLNNGDGTFTFITSVS--------LGGGGGGLSVAVgDLDGDGRLDLLV 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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