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Conserved domains on  [gi|6754774|ref|NP_034986|]
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myosin-6 [Mus musculus]

Protein Classification

myosin heavy chain( domain architecture ID 13677817)

myosin heavy chain of class II myosin (or conventional myosin), which contains two heavy chains made up of the motor/head (N-terminal) and coiled-coil tail (C-terminal) domains; the head ATPase activity and functions as a molecular motor, utilizing ATP hydrolysis to generate directed movement toward the plus end along actin filaments

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MYSc_class_II cd01377
class II myosins, motor domain; Myosin motor domain in class II myosins. Class II myosins, ...
99-768 0e+00

class II myosins, motor domain; Myosin motor domain in class II myosins. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. Thus, myosin II has two heads. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


:

Pssm-ID: 276951 [Multi-domain]  Cd Length: 662  Bit Score: 1338.26  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    99 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITG 178
Cdd:cd01377    1 ASVLHNLRERYYSDLIYTYSGLFCVAVNPYKRLPIYTEEVIDKYKGKRREEMPPHIFAIADNAYRNMLQDRENQSILITG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   179 ESGAGKTVNTKRVIQYFASIAAIGdrSKKENPNANKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGK 258
Cdd:cd01377   81 ESGAGKTENTKKVIQYLASVAASS--KKKKESGKKKGTLEDQILQANPILEAFGNAKTVRNNNSSRFGKFIRIHFGSTGK 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   259 LASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLDMLLVTNNPYDYAFVSQGEVSVASIDDSEELLATDSAFD 338
Cdd:cd01377  159 IAGADIETYLLEKSRVVRQAKGERNYHIFYQLLSGADPELKEKLLLTGDPSYYFFLSQGELTIDGVDDAEEFKLTDEAFD 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   339 VLSFTAEEKAGVYKLTGAIMHYGNMKFKQKQREEQAEPDGTEDADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQSV 418
Cdd:cd01377  239 ILGFSEEEKMSIFKIVAAILHLGNIKFKQRRREEQAELDGTEEADKAAHLLGVNSSDLLKALLKPRIKVGREWVTKGQNK 318
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   419 QQVYYSIGALAKSVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLE 498
Cdd:cd01377  319 EQVVFSVGALAKALYERLFLWLVKRINKTLDTKSKRQYFIGVLDIAGFEIFEFNSFEQLCINYTNEKLQQFFNHHMFVLE 398
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   499 QEEYKKEGIEWEFIDFGMDLQACIDLIEKP-MGIMSILEEECMFPKASDMTFKAKLYDNHLGKSNNFQKPRnvKGKQEAH 577
Cdd:cd01377  399 QEEYKKEGIEWTFIDFGLDLQPTIDLIEKPnMGILSILDEECVFPKATDKTFVEKLYSNHLGKSKNFKKPK--PKKSEAH 476
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   578 FSLVHYAGTVDYNIMGWLEKNKDPLNETVVGLYQKSSLKLMATLFSTYASADTGDsgkgKGGKKKGSSFQTVSALHRENL 657
Cdd:cd01377  477 FILKHYAGDVEYNIDGWLEKNKDPLNENVVALLKKSSDPLVASLFKDYEESGGGG----GKKKKKGGSFRTVSQLHKEQL 552
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   658 NKLMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQF 737
Cdd:cd01377  553 NKLMTTLRSTHPHFVRCIIPNEEKKPGKIDAPLVLHQLRCNGVLEGIRICRKGFPNRIIFAEFKQRYSILAPNAIPKGFD 632
                        650       660       670
                 ....*....|....*....|....*....|.
gi 6754774   738 iDSRKGAEKLLGSLDIDHNQYKFGHTKVFFK 768
Cdd:cd01377  633 -DGKAACEKILKALQLDPELYRIGNTKVFFK 662
Myosin_tail_1 super family cl37647
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
848-1925 1.57e-165

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


The actual alignment was detected with superfamily member pfam01576:

Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 535.91  E-value: 1.57e-165
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     848 EKEMANMKEEFGRVKDALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKIQLEAKVKEMTER 927
Cdd:pfam01576    4 EEEMQAKEEELQKVKERQQKAESELKELEKKHQQLCEEKNALQEQLQAETELCAEAEEMRARLAARKQELEEILHELESR 83
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     928 LEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQ 1007
Cdd:pfam01576   84 LEEEEERSQQLQNEKKKMQQHIQDLEEQLDEEEAARQKLQLEKVTTEAKIKKLEEDILLLEDQNSKLSKERKLLEERISE 163
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1008 ALDDLQAEEDKVNTLTKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEF 1087
Cdd:pfam01576  164 FTSNLAEEEEKAKSLSKLKNKHEAMISDLEERLKKEEKGRQELEKAKRKLEGESTDLQEQIAELQAQIAELRAQLAKKEE 243
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1088 DISQQNSKIEDEQALALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNK 1167
Cdd:pfam01576  244 ELQAALARLEEETAQKNNALKKIRELEAQISELQEDLESERAARNKAEKQRRDLGEELEALKTELEDTLDTTAAQQELRS 323
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1168 KREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANL 1247
Cdd:pfam01576  324 KREQEVTELKKALEEETRSHEAQLQEMRQKHTQALEELTEQLEQAKRNKANLEKAKQALESENAELQAELRTLQQAKQDS 403
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1248 EKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKA 1327
Cdd:pfam01576  404 EHKRKKLEGQLQELQARLSESERQRAELAEKLSKLQSELESVSSLLNEAEGKNIKLSKDVSSLESQLQDTQELLQEETRQ 483
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1328 KNALAHALQSSRHDCDLLREQYEEEMEAKAELQRVLSKANSEVAQWRTKYETDAiQRTEELEEAKKKLAQRLQDAEEAVE 1407
Cdd:pfam01576  484 KLNLSTRLRQLEDERNSLQEQLEEEEEAKRNVERQLSTLQAQLSDMKKKLEEDA-GTLEALEEGKKRLQRELEALTQQLE 562
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1408 AVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLK 1487
Cdd:pfam01576  563 EKAAAYDKLEKTKNRLQQELDDLLVDLDHQRQLVSNLEKKQKKFDQMLAEEKAISARYAEERDRAEAEAREKETRALSLA 642
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1488 NAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKIRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEF 1567
Cdd:pfam01576  643 RALEEALEAKEELERTNKQLRAEMEDLVSSKDDVGKNVHELERSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNM 722
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1568 NQIKAEIERKLAEKDEEMEQAKRNHLRMVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSQANRIASEAQKHLKN 1647
Cdd:pfam01576  723 QALKAQFERDLQARDEQGEEKRRQLVKQVRELEAELEDERKQRAQAVAAKKKLELDLKELEAQIDAANKGREEAVKQLKK 802
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1648 SQAHLKDTQLQLDDAVHANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLIN 1727
Cdd:pfam01576  803 LQAQMKDLQRELEEARASRDEILAQSKESEKKLKNLEAELLQLQEDLAASERARRQAQQERDELADEIASGASGKSALQD 882
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1728 QKKKMESDLTQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIAL 1807
Cdd:pfam01576  883 EKRRLEARIAQLEEELEEEQSNTELLNDRLRKSTLQVEQLTTELAAERSTSQKSESARQQLERQNKELKAKLQEMEGTVK 962
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1808 KGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLMRLQDLVDKLQLKVKAYKRQAEEA 1887
Cdd:pfam01576  963 SKFKSSIAALEAKIAQLEEQLEQESRERQAANKLVRRTEKKLKEVLLQVEDERRHADQYKDQAEKGNSRMKQLKRQLEEA 1042
                         1050      1060      1070
                   ....*....|....*....|....*....|....*...
gi 6754774    1888 EEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAK 1925
Cdd:pfam01576 1043 EEEASRANAARRKLQRELDDATESNESMNREVSTLKSK 1080
Myosin_N pfam02736
Myosin N-terminal SH3-like domain; This domain has an SH3-like fold. It is found at the ...
32-76 2.79e-14

Myosin N-terminal SH3-like domain; This domain has an SH3-like fold. It is found at the N-terminus of many but not all myosins. The function of this domain is unknown.


:

Pssm-ID: 460670  Cd Length: 45  Bit Score: 68.61  E-value: 2.79e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 6754774      32 DIRTECFVPDDKEEYVKAKVVSREGGKVTAETENGKTVTIKEDQV 76
Cdd:pfam02736    1 DAKKLVWVPDPKEGFVKGEIKEEEGDKVTVETEDGKTVTVKKDDV 45
 
Name Accession Description Interval E-value
MYSc_class_II cd01377
class II myosins, motor domain; Myosin motor domain in class II myosins. Class II myosins, ...
99-768 0e+00

class II myosins, motor domain; Myosin motor domain in class II myosins. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. Thus, myosin II has two heads. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276951 [Multi-domain]  Cd Length: 662  Bit Score: 1338.26  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    99 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITG 178
Cdd:cd01377    1 ASVLHNLRERYYSDLIYTYSGLFCVAVNPYKRLPIYTEEVIDKYKGKRREEMPPHIFAIADNAYRNMLQDRENQSILITG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   179 ESGAGKTVNTKRVIQYFASIAAIGdrSKKENPNANKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGK 258
Cdd:cd01377   81 ESGAGKTENTKKVIQYLASVAASS--KKKKESGKKKGTLEDQILQANPILEAFGNAKTVRNNNSSRFGKFIRIHFGSTGK 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   259 LASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLDMLLVTNNPYDYAFVSQGEVSVASIDDSEELLATDSAFD 338
Cdd:cd01377  159 IAGADIETYLLEKSRVVRQAKGERNYHIFYQLLSGADPELKEKLLLTGDPSYYFFLSQGELTIDGVDDAEEFKLTDEAFD 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   339 VLSFTAEEKAGVYKLTGAIMHYGNMKFKQKQREEQAEPDGTEDADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQSV 418
Cdd:cd01377  239 ILGFSEEEKMSIFKIVAAILHLGNIKFKQRRREEQAELDGTEEADKAAHLLGVNSSDLLKALLKPRIKVGREWVTKGQNK 318
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   419 QQVYYSIGALAKSVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLE 498
Cdd:cd01377  319 EQVVFSVGALAKALYERLFLWLVKRINKTLDTKSKRQYFIGVLDIAGFEIFEFNSFEQLCINYTNEKLQQFFNHHMFVLE 398
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   499 QEEYKKEGIEWEFIDFGMDLQACIDLIEKP-MGIMSILEEECMFPKASDMTFKAKLYDNHLGKSNNFQKPRnvKGKQEAH 577
Cdd:cd01377  399 QEEYKKEGIEWTFIDFGLDLQPTIDLIEKPnMGILSILDEECVFPKATDKTFVEKLYSNHLGKSKNFKKPK--PKKSEAH 476
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   578 FSLVHYAGTVDYNIMGWLEKNKDPLNETVVGLYQKSSLKLMATLFSTYASADTGDsgkgKGGKKKGSSFQTVSALHRENL 657
Cdd:cd01377  477 FILKHYAGDVEYNIDGWLEKNKDPLNENVVALLKKSSDPLVASLFKDYEESGGGG----GKKKKKGGSFRTVSQLHKEQL 552
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   658 NKLMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQF 737
Cdd:cd01377  553 NKLMTTLRSTHPHFVRCIIPNEEKKPGKIDAPLVLHQLRCNGVLEGIRICRKGFPNRIIFAEFKQRYSILAPNAIPKGFD 632
                        650       660       670
                 ....*....|....*....|....*....|.
gi 6754774   738 iDSRKGAEKLLGSLDIDHNQYKFGHTKVFFK 768
Cdd:cd01377  633 -DGKAACEKILKALQLDPELYRIGNTKVFFK 662
Myosin_head pfam00063
Myosin head (motor domain);
87-768 0e+00

Myosin head (motor domain);


Pssm-ID: 395017 [Multi-domain]  Cd Length: 674  Bit Score: 1081.15  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774      87 IEDMAMLTFLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYML 166
Cdd:pfam00063    1 VEDMVELSYLNEPSVLHNLKKRYKSDLIYTYSGLVLVAVNPYKQLPIYSEDMIKAYRGKRRGELPPHIFAIADEAYRSML 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     167 TDRENQSILITGESGAGKTVNTKRVIQYFASIAAIGDRSkkenpnaNKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFG 246
Cdd:pfam00063   81 QDKENQSILISGESGAGKTENTKKIMQYLASVSGSGSAG-------NVGRLEEQILQSNPILEAFGNAKTVRNNNSSRFG 153
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     247 KFIRIHFGATGKLASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLDMLLVTnNPYDYAFVSQ-GEVSVASID 325
Cdd:pfam00063  154 KYIEIQFDAKGDIVGGKIETYLLEKSRVVYQAEGERNYHIFYQLLAGASAQLKKELRLT-NPKDYHYLSQsGCYTIDGID 232
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     326 DSEELLATDSAFDVLSFTAEEKAGVYKLTGAIMHYGNMKFKQKQREEQAEPDGTEDADKSAYLMGLNSADLLKGLCHPRV 405
Cdd:pfam00063  233 DSEEFKITDKAMDILGFSDEEQMGIFRIVAAILHLGNIEFKKERNDEQAVPDDTENLQKAASLLGIDSTELEKALCKRRI 312
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     406 KVGNEYVTKGQSVQQVYYSIGALAKSVYEKMFNWMVTRINATLETKQ-PRQYFIGVLDIAGFEIFDFNSFEQLCINFTNE 484
Cdd:pfam00063  313 KTGRETVSKPQNVEQANYARDALAKAIYSRLFDWLVDRINKSLDVKTiEKASFIGVLDIYGFEIFEKNSFEQLCINYVNE 392
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     485 KLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGmDLQACIDLIE-KPMGIMSILEEECMFPKASDMTFKAKLYDNHlGKSNN 563
Cdd:pfam00063  393 KLQQFFNHHMFKLEQEEYVREGIEWTFIDFG-DNQPCIDLIEkKPLGILSLLDEECLFPKATDQTFLDKLYSTF-SKHPH 470
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     564 FQKPRNvkgKQEAHFSLVHYAGTVDYNIMGWLEKNKDPLNETVVGLYQKSSLKLMATLF---STYASADTGDSGKGKGGK 640
Cdd:pfam00063  471 FQKPRL---QGETHFIIKHYAGDVEYNVEGFLEKNKDPLNDDLVSLLKSSSDPLLAELFpdyETAESAAANESGKSTPKR 547
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     641 KKGSSFQTVSALHRENLNKLMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDF 720
Cdd:pfam00063  548 TKKKRFITVGSQFKESLGELMKTLNSTNPHYIRCIKPNEKKRAGVFDNSLVLHQLRCNGVLEGIRIRRAGFPNRITFQEF 627
                          650       660       670       680
                   ....*....|....*....|....*....|....*....|....*...
gi 6754774     721 RQRYRILNPAAIPEGqFIDSRKGAEKLLGSLDIDHNQYKFGHTKVFFK 768
Cdd:pfam00063  628 VQRYRILAPKTWPKW-KGDAKKGCEAILQSLNLDKEEYQFGKTKIFFR 674
MYSc smart00242
Myosin. Large ATPases; ATPase; molecular motor. Muscle contraction consists of a cyclical ...
80-780 0e+00

Myosin. Large ATPases; ATPase; molecular motor. Muscle contraction consists of a cyclical interaction between myosin and actin. The core of the myosin structure is similar in fold to that of kinesin.


Pssm-ID: 214580 [Multi-domain]  Cd Length: 677  Bit Score: 1018.24  E-value: 0e+00
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774       80 NPPKFDKIEDMAMLTFLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISD 159
Cdd:smart00242    1 NPPKFEGVEDLVLLTYLNEPAVLHNLKKRYLKDLIYTYIGLVLVAVNPYKQLPIYTDEVIKKYRGKSRGELPPHVFAIAD 80
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774      160 NAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFASIAAigdrskkenPNANKGTLEDQIIQANPALEAFGNAKTVRN 239
Cdd:smart00242   81 NAYRNMLNDKENQSIIISGESGAGKTENTKKIMQYLASVSG---------SNTEVGSVEDQILESNPILEAFGNAKTLRN 151
                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774      240 DNSSRFGKFIRIHFGATGKLASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLDMLLVTNnPYDYAFVSQG-E 318
Cdd:smart00242  152 NNSSRFGKFIEIHFDAKGKIIGAKIETYLLEKSRVVSQAKGERNYHIFYQLLAGASEELKKELGLKS-PEDYRYLNQGgC 230
                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774      319 VSVASIDDSEELLATDSAFDVLSFTAEEKAGVYKLTGAIMHYGNMKFKQKQREEQA-EPDGTEDADKSAYLMGLNSADLL 397
Cdd:smart00242  231 LTVDGIDDAEEFKETLNAMRVLGFSEEEQESIFKILAAILHLGNIEFEEGRNDNAAsTVKDKEELSNAAELLGVDPEELE 310
                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774      398 KGLCHPRVKVGNEYVTKGQSVQQVYYSIGALAKSVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQL 477
Cdd:smart00242  311 KALTKRKIKTGGEVITKPLNVEQALDARDALAKALYSRLFDWLVKRINQSLSFKDGSTYFIGVLDIYGFEIFEVNSFEQL 390
                           410       420       430       440       450       460       470       480
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774      478 CINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGmDLQACIDLIE-KPMGIMSILEEECMFPKASDMTFKAKLYdN 556
Cdd:smart00242  391 CINYANEKLQQFFNQHVFKLEQEEYEREGIDWTFIDFF-DNQDCIDLIEkKPPGILSLLDEECRFPKGTDQTFLEKLN-Q 468
                           490       500       510       520       530       540       550       560
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774      557 HLGKSNNFQKPRNvkgKQEAHFSLVHYAGTVDYNIMGWLEKNKDPLNETVVGLYQKSSLKLMATLFSTYASADTGDsgkg 636
Cdd:smart00242  469 HHKKHPHFSKPKK---KGRTEFIIKHYAGDVTYDVTGFLEKNKDTLSDDLIELLQSSKNPLIASLFPSGVSNAGSK---- 541
                           570       580       590       600       610       620       630       640
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774      637 kggkkkgSSFQTVSALHRENLNKLMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRIL 716
Cdd:smart00242  542 -------KRFQTVGSQFKEQLNELMDTLNSTNPHFIRCIKPNEEKKPGDFDSSLVLHQLRYLGVLENIRIRRAGFPYRLP 614
                           650       660       670       680       690       700
                    ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6754774      717 YGDFRQRYRILNPAAIPEGQFiDSRKGAEKLLGSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRD 780
Cdd:smart00242  615 FDEFLQRYRVLLPDTWPPWGG-DAKKACEALLQSLGLDEDEYQLGKTKVFLRPGQLAELEELRE 677
COG5022 COG5022
Myosin heavy chain [General function prediction only];
31-1086 0e+00

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 840.12  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    31 FDIRTECFVPDDKEEYVKAKVVSRE--GGKVTAE--TENGKTVTIKEDQVMQ--QNPPKFDKIEDMAMLTFLHEPAVLYN 104
Cdd:COG5022    6 AEVGSGCWIPDEEKGWIWAEIIKEAfnKGKVTEEgkKEDGESVSVKKKVLGNdrIKLPKFDGVDDLTELSYLNEPAVLHN 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   105 LKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGESGAGK 184
Cdd:COG5022   86 LEKRYNNGQIYTYSGLVLIAVNPYRDLGIYTDDIIQSYSGKNRLELEPHVFAIAEEAYRNLLSEKENQTIIISGESGAGK 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   185 TVNTKRVIQYFASIAAigdrskkeNPNANKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADI 264
Cdd:COG5022  166 TENAKRIMQYLASVTS--------SSTVEISSIEKQILATNPILEAFGNAKTVRNDNSSRFGKYIKIEFDENGEICGAKI 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   265 ETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLDMLLVTNnPYDYAFVSQGEV-SVASIDDSEELLATDSAFDVLSFT 343
Cdd:COG5022  238 ETYLLEKSRVVHQNKNERNYHIFYQLLAGDPEELKKLLLLQN-PKDYIYLSQGGCdKIDGIDDAKEFKITLDALKTIGID 316
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   344 AEEKAGVYKLTGAIMHYGNMKFKqKQREEQAEPDGTEDADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQSVQQVYY 423
Cdd:COG5022  317 EEEQDQIFKILAAILHIGNIEFK-EDRNGAAIFSDNSVLDKACYLLGIDPSLFVKWLVKRQIKTGGEWIVVPLNLEQALA 395
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   424 SIGALAKSVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYK 503
Cdd:COG5022  396 IRDSLAKALYSNLFDWIVDRINKSLDHSAAASNFIGVLDIYGFEIFEKNSFEQLCINYTNEKLQQFFNQHMFKLEQEEYV 475
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   504 KEGIEWEFIDFgMDLQACIDLIEK--PMGIMSILEEECMFPKASDMTFKAKLYDN-HLGKSNNFQKPRNVKGKqeahFSL 580
Cdd:COG5022  476 KEGIEWSFIDY-FDNQPCIDLIEKknPLGILSLLDEECVMPHATDESFTSKLAQRlNKNSNPKFKKSRFRDNK----FVV 550
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   581 VHYAGTVDYNIMGWLEKNKDPLNETVVGLYQKSSLKLMATLFSTYASADTgdsgkgkggkkkGSSFQTVSALHRENLNKL 660
Cdd:COG5022  551 KHYAGDVEYDVEGFLDKNKDPLNDDLLELLKASTNEFVSTLFDDEENIES------------KGRFPTLGSRFKESLNSL 618
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   661 MTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQFI-- 738
Cdd:COG5022  619 MSTLNSTQPHYIRCIKPNEEKSPWTFDNQMVLSQLRCCGVLETIRISRAGFPSRWTFDEFVQRYRILSPSKSWTGEYTwk 698
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   739 -DSRKGAEKLLGSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRDERLSRIITRIQAQARGQLMRIEFKKIVERRDALLVIQ 817
Cdd:COG5022  699 eDTKNAVKSILEELVIDSSKYQIGNTKVFFKAGVLAALEDMRDAKLDNIATRIQRAIRGRYLRRRYLQALKRIKKIQVIQ 778
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   818 WNIRAFMGVKNWPWMKLYFKIKPLLKSAETEKEM---------------------ANMKEEFGRVKDALeKSEARRKELE 876
Cdd:COG5022  779 HGFRLRRLVDYELKWRLFIKLQPLLSLLGSRKEYrsylaciiklqktikrekklrETEEVEFSLKAEVL-IQKFGRSLKA 857
                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   877 EKMVSLLQEKNdLQLQVQAEQDN-------LNDAEERCDQL-----------------------IKNKIQLE--AKVKEM 924
Cdd:COG5022  858 KKRFSLLKKET-IYLQSAQRVELaerqlqeLKIDVKSISSLklvnleleseiielkkslssdliENLEFKTEliARLKKL 936
                        970       980       990      1000      1010      1020      1030      1040
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   925 TE--RLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLakveKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQ 1002
Cdd:COG5022  937 LNniDLEEGPSIEYVKLPELNKLHEVESKLKETSEEYEDLL----KKSTILVREGNKANSELKNFKKELAELSKQYGALQ 1012
                       1050      1060      1070      1080      1090      1100      1110      1120
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1003 EAHQQ------ALDDLQAEEDKVNTLTKSKvKLEQQVDDLEGSLEQEKK------VRMDLERAKRKLEGDLKLTQESIMD 1070
Cdd:COG5022 1013 ESTKQlkelpvEVAELQSASKIISSESTEL-SILKPLQKLKGLLLLENNqlqaryKALKLRRENSLLDDKQLYQLESTEN 1091
                       1130
                 ....*....|....*.
gi 6754774  1071 LENDKLQLEEKLKKKE 1086
Cdd:COG5022 1092 LLKTINVKDLEVTNRN 1107
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
848-1925 1.57e-165

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 535.91  E-value: 1.57e-165
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     848 EKEMANMKEEFGRVKDALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKIQLEAKVKEMTER 927
Cdd:pfam01576    4 EEEMQAKEEELQKVKERQQKAESELKELEKKHQQLCEEKNALQEQLQAETELCAEAEEMRARLAARKQELEEILHELESR 83
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     928 LEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQ 1007
Cdd:pfam01576   84 LEEEEERSQQLQNEKKKMQQHIQDLEEQLDEEEAARQKLQLEKVTTEAKIKKLEEDILLLEDQNSKLSKERKLLEERISE 163
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1008 ALDDLQAEEDKVNTLTKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEF 1087
Cdd:pfam01576  164 FTSNLAEEEEKAKSLSKLKNKHEAMISDLEERLKKEEKGRQELEKAKRKLEGESTDLQEQIAELQAQIAELRAQLAKKEE 243
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1088 DISQQNSKIEDEQALALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNK 1167
Cdd:pfam01576  244 ELQAALARLEEETAQKNNALKKIRELEAQISELQEDLESERAARNKAEKQRRDLGEELEALKTELEDTLDTTAAQQELRS 323
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1168 KREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANL 1247
Cdd:pfam01576  324 KREQEVTELKKALEEETRSHEAQLQEMRQKHTQALEELTEQLEQAKRNKANLEKAKQALESENAELQAELRTLQQAKQDS 403
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1248 EKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKA 1327
Cdd:pfam01576  404 EHKRKKLEGQLQELQARLSESERQRAELAEKLSKLQSELESVSSLLNEAEGKNIKLSKDVSSLESQLQDTQELLQEETRQ 483
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1328 KNALAHALQSSRHDCDLLREQYEEEMEAKAELQRVLSKANSEVAQWRTKYETDAiQRTEELEEAKKKLAQRLQDAEEAVE 1407
Cdd:pfam01576  484 KLNLSTRLRQLEDERNSLQEQLEEEEEAKRNVERQLSTLQAQLSDMKKKLEEDA-GTLEALEEGKKRLQRELEALTQQLE 562
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1408 AVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLK 1487
Cdd:pfam01576  563 EKAAAYDKLEKTKNRLQQELDDLLVDLDHQRQLVSNLEKKQKKFDQMLAEEKAISARYAEERDRAEAEAREKETRALSLA 642
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1488 NAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKIRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEF 1567
Cdd:pfam01576  643 RALEEALEAKEELERTNKQLRAEMEDLVSSKDDVGKNVHELERSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNM 722
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1568 NQIKAEIERKLAEKDEEMEQAKRNHLRMVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSQANRIASEAQKHLKN 1647
Cdd:pfam01576  723 QALKAQFERDLQARDEQGEEKRRQLVKQVRELEAELEDERKQRAQAVAAKKKLELDLKELEAQIDAANKGREEAVKQLKK 802
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1648 SQAHLKDTQLQLDDAVHANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLIN 1727
Cdd:pfam01576  803 LQAQMKDLQRELEEARASRDEILAQSKESEKKLKNLEAELLQLQEDLAASERARRQAQQERDELADEIASGASGKSALQD 882
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1728 QKKKMESDLTQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIAL 1807
Cdd:pfam01576  883 EKRRLEARIAQLEEELEEEQSNTELLNDRLRKSTLQVEQLTTELAAERSTSQKSESARQQLERQNKELKAKLQEMEGTVK 962
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1808 KGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLMRLQDLVDKLQLKVKAYKRQAEEA 1887
Cdd:pfam01576  963 SKFKSSIAALEAKIAQLEEQLEQESRERQAANKLVRRTEKKLKEVLLQVEDERRHADQYKDQAEKGNSRMKQLKRQLEEA 1042
                         1050      1060      1070
                   ....*....|....*....|....*....|....*...
gi 6754774    1888 EEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAK 1925
Cdd:pfam01576 1043 EEEASRANAARRKLQRELDDATESNESMNREVSTLKSK 1080
PTZ00014 PTZ00014
myosin-A; Provisional
62-821 6.90e-125

myosin-A; Provisional


Pssm-ID: 240229 [Multi-domain]  Cd Length: 821  Bit Score: 414.43  E-value: 6.90e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     62 ETENGKTVTIKEDQVMQQNPP-KFDKIEDMAMLTFLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVA 140
Cdd:PTZ00014   72 DPPTNSTFEVKPEHAFNANSQiDPMTYGDIGLLPHTNIPCVLDFLKHRYLKNQIYTTADPLLVAINPFKDLGNTTNDWIR 151
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    141 AYR-GKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFASiaaigdrSKKENpnaNKGTLED 219
Cdd:PTZ00014  152 RYRdAKDSDKLPPHVFTTARRALENLHGVKKSQTIIVSGESGAGKTEATKQIMRYFAS-------SKSGN---MDLKIQN 221
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    220 QIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELL 299
Cdd:PTZ00014  222 AIMAANPVLEAFGNAKTIRNNNSSRFGRFMQLQLGEEGGIRYGSIVAFLLEKSRVVTQEDDERSYHIFYQLLKGANDEMK 301
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    300 DMLLVTNNPyDYAFVSQGEVSVASIDDSEELLATDSAFDVLSFTAEEKAGVYKLTGAIMHYGNMKFKQKqrEEQAEPDGT 379
Cdd:PTZ00014  302 EKYKLKSLE-EYKYINPKCLDVPGIDDVKDFEEVMESFDSMGLSESQIEDIFSILSGVLLLGNVEIEGK--EEGGLTDAA 378
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    380 EDADKS-------AYLMGLNSADLLKGLCHPRVKVGNEYVTKGQSVQQVYYSIGALAKSVYEKMFNWMVTRINATLETKQ 452
Cdd:PTZ00014  379 AISDESlevfneaCELLFLDYESLKKELTVKVTYAGNQKIEGPWSKDESEMLKDSLSKAVYEKLFLWIIRNLNATIEPPG 458
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    453 PRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLQACIDLIEKPMGIM 532
Cdd:PTZ00014  459 GFKVFIGMLDIFGFEVFKNNSLEQLFINITNEMLQKNFVDIVFERESKLYKDEGISTEELEYTSNESVIDLLCGKGKSVL 538
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    533 SILEEECMFPKASDMTFKAKLYDNHlgKSNNFQKPrnVKGKQEAHFSLVHYAGTVDYNIMGWLEKNKDPLNETVVGLYQK 612
Cdd:PTZ00014  539 SILEDQCLAPGGTDEKFVSSCNTNL--KNNPKYKP--AKVDSNKNFVIKHTIGDIQYCASGFLFKNKDVLRPELVEVVKA 614
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    613 SSLKLMATLFStyasadtGDSGKGKGGKKKgssfQTVSALHRENLNKLMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVM 692
Cdd:PTZ00014  615 SPNPLVRDLFE-------GVEVEKGKLAKG----QLIGSQFLNQLDSLMSLINSTEPHFIRCIKPNENKKPLDWNSSKVL 683
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    693 HQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNpAAIPEGQFIDSRKGAEKLLGSLDIDHNQYKFGHTKVFFKAGLL 772
Cdd:PTZ00014  684 IQLHSLSILEALQLRQLGFSYRRTFAEFLSQFKYLD-LAVSNDSSLDPKEKAEKLLERSGLPKDSYAIGKTMVFLKKDAA 762
                         730       740       750       760       770
                  ....*....|....*....|....*....|....*....|....*....|..
gi 6754774    773 GLLEEMRDERLSR---IITRIQAQARGQLMRIEFKKIVErrdALLVIQWNIR 821
Cdd:PTZ00014  763 KELTQIQREKLAAwepLVSVLEALILKIKKKRKVRKNIK---SLVRIQAHLR 811
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
846-1745 2.16e-30

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 131.72  E-value: 2.16e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     846 ETEKEMANMKEEFGRVKDALeksearrKELEEKMVSllqekndlqLQVQAEQdnlndAEercdQLIKNKIQLEAKVKEM- 924
Cdd:TIGR02168  176 ETERKLERTRENLDRLEDIL-------NELERQLKS---------LERQAEK-----AE----RYKELKAELRELELALl 230
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     925 TERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEA 1004
Cdd:TIGR02168  231 VLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRER 310
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1005 HQQALDDLQAEEDKVNTLTKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKK 1084
Cdd:TIGR02168  311 LANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQ 390
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1085 KEFDISQQNSKIEDEQALALQLQKKLKENQARIEELEeeleaertaRAKVEKLRSDLSRELEEISERLEEAGGATSVQIE 1164
Cdd:TIGR02168  391 LELQIASLNNEIERLEARLERLEDRRERLQQEIEELL---------KKLEEAELKELQAELEELEEELEELQEELERLEE 461
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1165 MNKKREAEFQKMRRDLEEATLQHEATAAALrkkhaDSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTsnmeQIIKAK 1244
Cdd:TIGR02168  462 ALEELREELEEAEQALDAAERELAQLQARL-----DSLERLQENLEGFSEGVKALLKNQSGLSGILGVLS----ELISVD 532
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1245 ANLEK-VSRTLEDQANEYRVKLEEAQRSLNDFTTQ----RAKLQTENGELARQLEEKEALISQLTRGKLSYtqqmedLKR 1319
Cdd:TIGR02168  533 EGYEAaIEAALGGRLQAVVVENLNAAKKAIAFLKQnelgRVTFLPLDSIKGTEIQGNDREILKNIEGFLGV------AKD 606
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1320 QLEEEGKAKNALAHALQSSRHDCDL-----LREQYEEEMEAkAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKK 1394
Cdd:TIGR02168  607 LVKFDPKLRKALSYLLGGVLVVDDLdnaleLAKKLRPGYRI-VTLDGDLVRPGGVITGGSAKTNSSILERRREIEELEEK 685
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1395 LAQRLQDAEEAVEAVNAkcssLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQK 1474
Cdd:TIGR02168  686 IEELEEKIAELEKALAE----LRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEA 761
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1475 EARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGeggknvhELEKIRKQLEVEKLELQSALEEAEASLE 1554
Cdd:TIGR02168  762 EIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALD-------ELRAELTLLNEEAANLRERLESLERRIA 834
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1555 HEEGKILRAQLEFNQIKAEIErKLAEKDEEMEQAKRNHLRMVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSQA 1634
Cdd:TIGR02168  835 ATERRLEDLEEQIEELSEDIE-SLAAEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKRSEL 913
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1635 NRIASEAQKHLKNSQAHLKDTQLQLDD-AVHANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRK-------LAEQ 1706
Cdd:TIGR02168  914 RRELEELREKLAQLELRLEGLEVRIDNlQERLSEEYSLTLEEAEALENKIEDDEEEARRRLKRLENKIKelgpvnlAAIE 993
                          890       900       910
                   ....*....|....*....|....*....|....*....
gi 6754774    1707 ELIETSERVQLLHSQNTSLINQKKKMESDLTQLQTEVEE 1745
Cdd:TIGR02168  994 EYEELKERYDFLTAQKEDLTEAKETLEEAIEEIDREARE 1032
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
835-1454 1.56e-26

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 118.89  E-value: 1.56e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   835 YFKIKPLLKSAETE---KEMANMKEEFGRVKDALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLI 911
Cdd:COG1196  215 YRELKEELKELEAElllLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELL 294
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   912 KNKIQLEAKVKEMTERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEII 991
Cdd:COG1196  295 AELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAEL 374
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   992 AKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDL 1071
Cdd:COG1196  375 AEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAEL 454
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1072 ENDKLQLEEKLKKKEFDISQQNSKIEDEQALALQLQKKLKENQARIEELEEELEAERTARAK---------VEKLRSDLS 1142
Cdd:COG1196  455 EEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLaglrglagaVAVLIGVEA 534
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1143 RELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKE 1222
Cdd:COG1196  535 AYEAALEAALAAALQNIVVEDDEVAAAAIEYLKAAKAGRATFLPLDKIRARAALAAALARGAIGAAVDLVASDLREADAR 614
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1223 KSEFKLELDDVTSnmeqiikAKANLEKVSRTLEDQANEYRVKLEEAQRSLndftTQRAKLQTENGELARQLEEKEALISQ 1302
Cdd:COG1196  615 YYVLGDTLLGRTL-------VAARLEAALRRAVTLAGRLREVTLEGEGGS----AGGSLTGGSRRELLAALLEAEAELEE 683
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1303 LTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSSRHDCDLLREQYEEEMEAKAELQRVLSKANSEVAqwrtKYETDAI 1382
Cdd:COG1196  684 LAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEA----LEELPEP 759
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1383 QRTEELEEAKKKLAQRLQD-------AEEAVEAVNAKCSSLEKTKHRLQNEIEDLM-----VDVERSNAAAAALDKKQRN 1450
Cdd:COG1196  760 PDLEELERELERLEREIEAlgpvnllAIEEYEELEERYDFLSEQREDLEEARETLEeaieeIDRETRERFLETFDAVNEN 839

                 ....
gi 6754774  1451 FDKI 1454
Cdd:COG1196  840 FQEL 843
PTZ00121 PTZ00121
MAEBL; Provisional
843-1591 1.80e-19

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 96.36  E-value: 1.80e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    843 KSAETEKEMANMKEEFGRVKDALEKSEARRKElEEKMVSLLQEKND---LQLQVQAEQDNLNDAEERCDQLIK------- 912
Cdd:PTZ00121 1118 EEAKKKAEDARKAEEARKAEDARKAEEARKAE-DAKRVEIARKAEDarkAEEARKAEDAKKAEAARKAEEVRKaeelrka 1196
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    913 ---NKIQlEAKVKEMTERLED----EEEMNAELTAK---KRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTE 982
Cdd:PTZ00121 1197 edaRKAE-AARKAEEERKAEEarkaEDAKKAEAVKKaeeAKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAE 1275
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    983 EMAGLDEII----------AKLTKEKKALQEAHQQALDDLQAEEDKVNT------LTKSKVKLEQQVDDLEGSLEQEKKV 1046
Cdd:PTZ00121 1276 EARKADELKkaeekkkadeAKKAEEKKKADEAKKKAEEAKKADEAKKKAeeakkkADAAKKKAEEAKKAAEAAKAEAEAA 1355
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1047 RMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFdisqqNSKIEDEQALALQLQKKLKENQariEELEEELEA 1126
Cdd:PTZ00121 1356 ADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEA-----KKKAEEDKKKADELKKAAAAKK---KADEAKKKA 1427
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1127 ERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEfqKMRRDLEEATLQHEATAAALR-KKHADSVAEL 1205
Cdd:PTZ00121 1428 EEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKAD--EAKKKAEEAKKADEAKKKAEEaKKKADEAKKA 1505
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1206 GEQIDNLQRVKQKLEKEKSEfKLELDDVTSNMEQIIKA--KANLEKVSRTLEDQANEYRVKLEEAQRSlndftTQRAKLQ 1283
Cdd:PTZ00121 1506 AEAKKKADEAKKAEEAKKAD-EAKKAEEAKKADEAKKAeeKKKADELKKAEELKKAEEKKKAEEAKKA-----EEDKNMA 1579
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1284 TENGELARQLEEKEaLISQLTRGKLSYTQQMEDLKRqlEEEGKAKNALAHALQSSRHDCDLLREQYEEEMEAKAELQRVL 1363
Cdd:PTZ00121 1580 LRKAEEAKKAEEAR-IEEVMKLYEEEKKMKAEEAKK--AEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAE 1656
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1364 SKANSEVAQWRTKYETDAiQRTEEL----EEAKKKLAQRLQDAEEA--VEAVNAKCSSLEKTKHRLQNEIEDLMVDVERS 1437
Cdd:PTZ00121 1657 EENKIKAAEEAKKAEEDK-KKAEEAkkaeEDEKKAAEALKKEAEEAkkAEELKKKEAEEKKKAEELKKAEEENKIKAEEA 1735
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1438 naaaaaldKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAY--EESLEHLETFKRENKNLQEEISDLT 1515
Cdd:PTZ00121 1736 --------KKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVieEELDEEDEKRRMEVDKKIKDIFDNF 1807
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1516 EQLGEGGKNVHELEKIRKQLEVEKLE-----LQSALEEAEASLEH------EEGKILRAQLEFNQIKAEIErklaEKDEE 1584
Cdd:PTZ00121 1808 ANIIEGGKEGNLVINDSKEMEDSAIKevadsKNMQLEEADAFEKHkfnknnENGEDGNKEADFNKEKDLKE----DDEEE 1883

                  ....*..
gi 6754774   1585 MEQAKRN 1591
Cdd:PTZ00121 1884 IEEADEI 1890
Myosin_N pfam02736
Myosin N-terminal SH3-like domain; This domain has an SH3-like fold. It is found at the ...
32-76 2.79e-14

Myosin N-terminal SH3-like domain; This domain has an SH3-like fold. It is found at the N-terminus of many but not all myosins. The function of this domain is unknown.


Pssm-ID: 460670  Cd Length: 45  Bit Score: 68.61  E-value: 2.79e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 6754774      32 DIRTECFVPDDKEEYVKAKVVSREGGKVTAETENGKTVTIKEDQV 76
Cdd:pfam02736    1 DAKKLVWVPDPKEGFVKGEIKEEEGDKVTVETEDGKTVTVKKDDV 45
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
971-1336 2.56e-04

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 46.16  E-value: 2.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    971 HATENKVKNLTEEMAGLDEIiakLTKEKKALQEAHQQALDDLQAEEDK---------VNTLTKSKVKLEQQVDDLEGSLE 1041
Cdd:NF033838   36 HAEEVRGGNNPTVTSSGNES---QKEHAKEVESHLEKILSEIQKSLDKrkhtqnvalNKKLSDIKTEYLYELNVLKEKSE 112
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1042 QE--KKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKK---------------------EFDISQQNSKIED 1098
Cdd:NF033838  113 AEltSKTKKELDAAFEQFKKDTLEPGKKVAEATKKVEEAEKKAKDQkeedrrnyptntyktleleiaESDVEVKKAELEL 192
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1099 EQALALQLQKKLKENQARIEELEEELEAERTARAKVEKlrsdlsrelEEISERLEEAGGATSVQIEMNKKREAEFQKMRR 1178
Cdd:NF033838  193 VKEEAKEPRDEEKIKQAKAKVESKKAEATRLEKIKTDR---------EKAEEEAKRRADAKLKEAVEKNVATSEQDKPKR 263
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1179 DLEEATLQHEATAAALRKKHADSVAELGEQidNLQRVKQKLEKEKSEFKLELDDVTSnmeqiiKAKANLEKVSR------ 1252
Cdd:NF033838  264 RAKRGVLGEPATPDKKENDAKSSDSSVGEE--TLPSPSLKPEKKVAEAEKKVEEAKK------KAKDQKEEDRRnyptnt 335
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1253 --TLEDQANEYRVKLEEAQRSLndfTTQRAKlQTENGELARQ----LEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGK 1326
Cdd:NF033838  336 ykTLELEIAESDVKVKEAELEL---VKEEAK-EPRNEEKIKQakakVESKKAEATRLEKIKTDRKKAEEEAKRKAAEEDK 411
                         410
                  ....*....|
gi 6754774   1327 AKNALAHALQ 1336
Cdd:NF033838  412 VKEKPAEQPQ 421
Spc7 smart00787
Spc7 kinetochore protein; This domain is found in cell division proteins which are required ...
904-1079 4.72e-04

Spc7 kinetochore protein; This domain is found in cell division proteins which are required for kinetochore-spindle association.


Pssm-ID: 197874 [Multi-domain]  Cd Length: 312  Bit Score: 44.62  E-value: 4.72e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774      904 EERCDQLIKNKIQLEAKVKEMTErleDEEEMNAELTakkrkledECSELKKDIDDLELTL-AKVEKEKHATENKVKNLTE 982
Cdd:smart00787  136 EWRMKLLEGLKEGLDENLEGLKE---DYKLLMKELE--------LLNSIKPKLRDRKDALeEELRQLKQLEDELEDCDPT 204
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774      983 EMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKSKVKLEQQVDDLEGSLEQEKKV-RMDLERAKRKLEGDL 1061
Cdd:smart00787  205 ELDRAKEKLKKLLQEIMIKVKKLEELEEELQELESKIEDLTNKKSELNTEIAEAEKKLEQCRGFtFKEIEKLKEQLKLLQ 284
                           170
                    ....*....|....*...
gi 6754774     1062 KLTQESIMDLENDKLQLE 1079
Cdd:smart00787  285 SLTGWKITKLSGNTLSMT 302
ClyA_Cry6Aa-like cd22656
Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes ...
936-1073 4.98e-04

Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes pesticidal Cry6Aa toxin from Bacillus thuringiensis, one of the many parasporal crystal (Cry) toxins produced during the sporulation phase of growth. Many of these proteins are toxic to numerous insect species and have been effectively used as proteinaceous insecticides to directly kill insect pests; some have been used to control insect growth on transgenic agricultural plants. Cry6Aa exists as a protoxin, which is activated by cleavage using trypsin. Structure studies for Cry6Aa support a mechanism of action by pore formation, similar to cytolysin A (ClyA)-type alpha pore-forming toxins (alpha-PFTs) such as HblB, and bioassay and mutation studies show that Cry6Aa is an active pore-forming toxin. Cry6Aa shows atypical features compared to other members of alpha-PFTs, including internal repeat sequences and small loop regions within major alpha helices.


Pssm-ID: 439154 [Multi-domain]  Cd Length: 309  Bit Score: 44.28  E-value: 4.98e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   936 AELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEII-AKLTKEKKALQeahQQALDDLQA 1014
Cdd:cd22656  110 EELEEAKKTIKALLDDLLKEAKKYQDKAAKVVDKLTDFENQTEKDQTALETLEKALkDLLTDEGGAIA---RKEIKDLQK 186
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6754774  1015 EEDKVNTLTKSKVK-----LEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLEN 1073
Cdd:cd22656  187 ELEKLNEEYAAKLKakideLKALIADDEAKLAAALRLIADLTAADTDLDNLLALIGPAIPALEK 250
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
1298-1580 5.31e-04

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 45.00  E-value: 5.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1298 ALISQLTRGKLSYTQQMEDLKRQLEEE--GKAKNALAHALQSSRHDcdlLREQYEEEMEAKAELQRVLSKANSEVAQWRT 1375
Cdd:NF033838   88 ALNKKLSDIKTEYLYELNVLKEKSEAEltSKTKKELDAAFEQFKKD---TLEPGKKVAEATKKVEEAEKKAKDQKEEDRR 164
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1376 KYETDAIqRTEELEEAKKKLaqRLQDAEEAVEAVNAKCSSLEKTkhrlqneIEDLMVDVERSNAAAAALDKKQRnfDKIL 1455
Cdd:NF033838  165 NYPTNTY-KTLELEIAESDV--EVKKAELELVKEEAKEPRDEEK-------IKQAKAKVESKKAEATRLEKIKT--DREK 232
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1456 AEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQL-----------GEGGKN 1524
Cdd:NF033838  233 AEEEAKRRADAKLKEAVEKNVATSEQDKPKRRAKRGVLGEPATPDKKENDAKSSDSSVGEETLpspslkpekkvAEAEKK 312
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6754774   1525 VHELEK----------------IRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAE 1580
Cdd:NF033838  313 VEEAKKkakdqkeedrrnyptnTYKTLELEIAESDVKVKEAELELVKEEAKEPRNEEKIKQAKAKVESKKAE 384
growth_prot_Scy NF041483
polarized growth protein Scy;
972-1937 7.30e-03

polarized growth protein Scy;


Pssm-ID: 469371 [Multi-domain]  Cd Length: 1293  Bit Score: 41.35  E-value: 7.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    972 ATENKVKNLTEEMAGLdeiIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKSKVKLEQQvddlEGSLEQEKKVRMDLE 1051
Cdd:NF041483  302 ANEQRTRTAKEEIARL---VGEATKEAEALKAEAEQALADARAEAEKLVAEAAEKARTVAA----EDTAAQLAKAARTAE 374
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1052 RAKRKLEGDLKLTQESIMDlENDKLQLE-----EKLKKKEFDISQQnskiedeqaLALQLQKKLKENQARieeLEEELEA 1126
Cdd:NF041483  375 EVLTKASEDAKATTRAAAE-EAERIRREaeaeaDRLRGEAADQAEQ---------LKGAAKDDTKEYRAK---TVELQEE 441
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1127 ERTARAKVEKLRSDLSRELEEIseRLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELG 1206
Cdd:NF041483  442 ARRLRGEAEQLRAEAVAEGERI--RGEARREAVQQIEEAARTAEELLTKAKADADELRSTATAESERVRTEAIERATTLR 519
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1207 EQIDN-LQRVKQKLEKEKSEFKLELDDVTSNMEQiiKAKANLEKVSRTLEDQA-----------NEYRVKLEEAQRSLND 1274
Cdd:NF041483  520 RQAEEtLERTRAEAERLRAEAEEQAEEVRAAAER--AARELREETERAIAARQaeaaeeltrlhTEAEERLTAAEEALAD 597
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1275 FTTQRAKLQTENGelarqlEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHAlQSSRHDCDLLREQYEEEME 1354
Cdd:NF041483  598 ARAEAERIRREAA------EETERLRTEAAERIRTLQAQAEQEAERLRTEAAADASAARA-EGENVAVRLRSEAAAEAER 670
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1355 AKAELQRVLSKANSEVAQWRTKYETDAiqrTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSlEKTKHRLQNEiedlmvdv 1434
Cdd:NF041483  671 LKSEAQESADRVRAEAAAAAERVGTEA---AEALAAAQEEAARRRREAEETLGSARAEADQ-ERERAREQSE-------- 738
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1435 ersnaaaaaldkkqrnfdKILAEWKQKYEESQSELESSQKEARSLSTELfkLKNAYEESLEHLETFKRENKNLQEEISDL 1514
Cdd:NF041483  739 ------------------ELLASARKRVEEAQAEAQRLVEEADRRATEL--VSAAEQTAQQVRDSVAGLQEQAEEEIAGL 798
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1515 TEQLGeggknvHELEKIRKQLEVEKLELQS-ALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEE--------M 1585
Cdd:NF041483  799 RSAAE------HAAERTRTEAQEEADRVRSdAYAERERASEDANRLRREAQEETEAAKALAERTVSEAIAEaerlrsdaS 872
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1586 EQAKRNHLRMVDSLQTSLDAETRSRNEALRVKKKMEGDlnemeiQLSQANRIASEAQKHLKNSQAHLKDTQLQLDDAVHA 1665
Cdd:NF041483  873 EYAQRVRTEASDTLASAEQDAARTRADAREDANRIRSD------AAAQADRLIGEATSEAERLTAEARAEAERLRDEARA 946
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1666 NDDLK--ENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTqLQTEV 1743
Cdd:NF041483  947 EAERVraDAAAQAEQLIAEATGEAERLRAEAAETVGSAQQHAERIRTEAERVKAEAAAEAERLRTEAREEADRT-LDEAR 1025
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1744 EEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAhLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEaRVRE 1823
Cdd:NF041483 1026 KDANKRRSEAAEQADTLITEAAAEADQLTAKAQEEA-LRTTTEAEAQADTMVGAARKEAERIVAEATVEGNSLVE-KART 1103
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1824 LENELEAEQKRNAESVKGmRKSERR------IKELTYQTEEDKKNLMRLQ-DLVDKLqlkVKAYKRQAEEAEEQ------ 1890
Cdd:NF041483 1104 DADELLVGARRDATAIRE-RAEELRdritgeIEELHERARRESAEQMKSAgERCDAL---VKAAEEQLAEAEAKakelvs 1179
                         970       980       990      1000      1010
                  ....*....|....*....|....*....|....*....|....*....|...
gi 6754774   1891 -ANTNLSKFR-----KVQHELDEAEERADIAESQVNKLRAKSrDIGAKKMHDE 1937
Cdd:NF041483 1180 dANSEASKVRiaavkKAEGLLKEAEQKKAELVREAEKIKAEA-EAEAKRTVEE 1231
 
Name Accession Description Interval E-value
MYSc_class_II cd01377
class II myosins, motor domain; Myosin motor domain in class II myosins. Class II myosins, ...
99-768 0e+00

class II myosins, motor domain; Myosin motor domain in class II myosins. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. Thus, myosin II has two heads. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276951 [Multi-domain]  Cd Length: 662  Bit Score: 1338.26  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    99 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITG 178
Cdd:cd01377    1 ASVLHNLRERYYSDLIYTYSGLFCVAVNPYKRLPIYTEEVIDKYKGKRREEMPPHIFAIADNAYRNMLQDRENQSILITG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   179 ESGAGKTVNTKRVIQYFASIAAIGdrSKKENPNANKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGK 258
Cdd:cd01377   81 ESGAGKTENTKKVIQYLASVAASS--KKKKESGKKKGTLEDQILQANPILEAFGNAKTVRNNNSSRFGKFIRIHFGSTGK 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   259 LASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLDMLLVTNNPYDYAFVSQGEVSVASIDDSEELLATDSAFD 338
Cdd:cd01377  159 IAGADIETYLLEKSRVVRQAKGERNYHIFYQLLSGADPELKEKLLLTGDPSYYFFLSQGELTIDGVDDAEEFKLTDEAFD 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   339 VLSFTAEEKAGVYKLTGAIMHYGNMKFKQKQREEQAEPDGTEDADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQSV 418
Cdd:cd01377  239 ILGFSEEEKMSIFKIVAAILHLGNIKFKQRRREEQAELDGTEEADKAAHLLGVNSSDLLKALLKPRIKVGREWVTKGQNK 318
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   419 QQVYYSIGALAKSVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLE 498
Cdd:cd01377  319 EQVVFSVGALAKALYERLFLWLVKRINKTLDTKSKRQYFIGVLDIAGFEIFEFNSFEQLCINYTNEKLQQFFNHHMFVLE 398
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   499 QEEYKKEGIEWEFIDFGMDLQACIDLIEKP-MGIMSILEEECMFPKASDMTFKAKLYDNHLGKSNNFQKPRnvKGKQEAH 577
Cdd:cd01377  399 QEEYKKEGIEWTFIDFGLDLQPTIDLIEKPnMGILSILDEECVFPKATDKTFVEKLYSNHLGKSKNFKKPK--PKKSEAH 476
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   578 FSLVHYAGTVDYNIMGWLEKNKDPLNETVVGLYQKSSLKLMATLFSTYASADTGDsgkgKGGKKKGSSFQTVSALHRENL 657
Cdd:cd01377  477 FILKHYAGDVEYNIDGWLEKNKDPLNENVVALLKKSSDPLVASLFKDYEESGGGG----GKKKKKGGSFRTVSQLHKEQL 552
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   658 NKLMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQF 737
Cdd:cd01377  553 NKLMTTLRSTHPHFVRCIIPNEEKKPGKIDAPLVLHQLRCNGVLEGIRICRKGFPNRIIFAEFKQRYSILAPNAIPKGFD 632
                        650       660       670
                 ....*....|....*....|....*....|.
gi 6754774   738 iDSRKGAEKLLGSLDIDHNQYKFGHTKVFFK 768
Cdd:cd01377  633 -DGKAACEKILKALQLDPELYRIGNTKVFFK 662
MYSc_Myh6 cd14916
class II myosin heavy chain 6, motor domain; Myosin motor domain of alpha (or fast) cardiac ...
99-768 0e+00

class II myosin heavy chain 6, motor domain; Myosin motor domain of alpha (or fast) cardiac muscle myosin heavy chain 6. Cardiac muscle myosin is a hexamer consisting of two heavy chain subunits, two light chain subunits, and two regulatory subunits. This gene encodes the alpha heavy chain subunit of cardiac myosin. Mutations in this gene cause familial hypertrophic cardiomyopathy and atrial septal defect. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276880 [Multi-domain]  Cd Length: 670  Bit Score: 1324.30  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    99 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITG 178
Cdd:cd14916    1 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   179 ESGAGKTVNTKRVIQYFASIAAIGDRSKKENPNANKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGK 258
Cdd:cd14916   81 ESGAGKTVNTKRVIQYFASIAAIGDRSKKENPNANKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGK 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   259 LASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLDMLLVTNNPYDYAFVSQGEVSVASIDDSEELLATDSAFD 338
Cdd:cd14916  161 LASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLDMLLVTNNPYDYAFVSQGEVSVASIDDSEELLATDSAFD 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   339 VLSFTAEEKAGVYKLTGAIMHYGNMKFKQKQREEQAEPDGTEDADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQSV 418
Cdd:cd14916  241 VLGFTAEEKAGVYKLTGAIMHYGNMKFKQKQREEQAEPDGTEDADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQSV 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   419 QQVYYSIGALAKSVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLE 498
Cdd:cd14916  321 QQVYYSIGALAKSVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLE 400
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   499 QEEYKKEGIEWEFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKASDMTFKAKLYDNHLGKSNNFQKPRNVKGKQEAHF 578
Cdd:cd14916  401 QEEYKKEGIEWEFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKASDMTFKAKLYDNHLGKSNNFQKPRNVKGKQEAHF 480
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   579 SLVHYAGTVDYNIMGWLEKNKDPLNETVVGLYQKSSLKLMATLFSTYASADTGDSGKGKGGKKKGSSFQTVSALHRENLN 658
Cdd:cd14916  481 SLVHYAGTVDYNILGWLEKNKDPLNETVVGLYQKSSLKLMATLFSTYASADTGDSGKGKGGKKKGSSFQTVSALHRENLN 560
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   659 KLMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQFI 738
Cdd:cd14916  561 KLMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQFI 640
                        650       660       670
                 ....*....|....*....|....*....|
gi 6754774   739 DSRKGAEKLLGSLDIDHNQYKFGHTKVFFK 768
Cdd:cd14916  641 DSRKGAEKLLGSLDIDHNQYKFGHTKVFFK 670
MYSc_Myh3 cd14913
class II myosin heavy chain 3, motor domain; Myosin motor domain of fetal skeletal muscle ...
99-768 0e+00

class II myosin heavy chain 3, motor domain; Myosin motor domain of fetal skeletal muscle myosin heavy chain 3 (MYHC-EMB, MYHSE1, HEMHC, SMHCE) in tetrapods including mammals, lizards, and frogs. This gene is a member of the MYH family and encodes a protein with an IQ domain and a myosin head-like domain. Mutations in this gene have been associated with two congenital contracture (arthrogryposis) syndromes, Freeman-Sheldon syndrome and Sheldon-Hall syndrome. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276878 [Multi-domain]  Cd Length: 668  Bit Score: 1292.32  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    99 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITG 178
Cdd:cd14913    1 PAVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPVYNPEVVEGYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   179 ESGAGKTVNTKRVIQYFASIAAIGDRSKKENPNAnKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGK 258
Cdd:cd14913   81 ESGAGKTVNTKRVIQYFATIAATGDLAKKKDSKM-KGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGK 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   259 LASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLDMLLVTNNPYDYAFVSQGEVSVASIDDSEELLATDSAFD 338
Cdd:cd14913  160 LASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIELLLITTNPYDYPFISQGEILVASIDDAEELLATDSAID 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   339 VLSFTAEEKAGVYKLTGAIMHYGNMKFKQKQREEQAEPDGTEDADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQSV 418
Cdd:cd14913  240 ILGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKTAYLMGLNSSDLLKALCFPRVKVGNEYVTKGQTV 319
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   419 QQVYYSIGALAKSVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLE 498
Cdd:cd14913  320 DQVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPRQHFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQFFNHHMFVLE 399
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   499 QEEYKKEGIEWEFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKASDMTFKAKLYDNHLGKSNNFQKPRNVKGKQEAHF 578
Cdd:cd14913  400 QEEYKKEGIEWTFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQKPKVVKGRAEAHF 479
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   579 SLVHYAGTVDYNIMGWLEKNKDPLNETVVGLYQKSSLKLMATLFSTYASADtGDSGKGKGGKKKGSSFQTVSALHRENLN 658
Cdd:cd14913  480 SLIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLYATFATAD-ADSGKKKVAKKKGSSFQTVSALFRENLN 558
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   659 KLMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQFI 738
Cdd:cd14913  559 KLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRVLNASAIPEGQFI 638
                        650       660       670
                 ....*....|....*....|....*....|
gi 6754774   739 DSRKGAEKLLGSLDIDHNQYKFGHTKVFFK 768
Cdd:cd14913  639 DSKKACEKLLASIDIDHTQYKFGHTKVFFK 668
MYSc_Myh7 cd14917
class II myosin heavy chain 7, motor domain; Myosin motor domain of beta (or slow) type I ...
99-768 0e+00

class II myosin heavy chain 7, motor domain; Myosin motor domain of beta (or slow) type I cardiac muscle myosin heavy chain 7 (also called CMH1, MPD1, and CMD1S). Muscle myosin is a hexameric protein containing 2 heavy chain subunits, 2 alkali light chain subunits, and 2 regulatory light chain subunits. It is expressed predominantly in normal human ventrical and in skeletal muscle tissues rich in slow-twitch type I muscle fibers. Changes in the relative abundance of this protein and the alpha (or fast) heavy subunit of cardiac myosin correlate with the contractile velocity of cardiac muscle. Its expression is also altered during thyroid hormone depletion and hemodynamic overloading. Mutations in this gene are associated with familial hypertrophic cardiomyopathy, myosin storage myopathy, dilated cardiomyopathy, and Laing early-onset distal myopathy. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276881 [Multi-domain]  Cd Length: 668  Bit Score: 1251.54  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    99 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITG 178
Cdd:cd14917    1 PAVLYNLKERYASWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   179 ESGAGKTVNTKRVIQYFASIAAIGDRSKKENpNANKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGK 258
Cdd:cd14917   81 ESGAGKTVNTKRVIQYFAVIAAIGDRSKKDQ-TPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGK 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   259 LASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLDMLLVTNNPYDYAFVSQGEVSVASIDDSEELLATDSAFD 338
Cdd:cd14917  160 LASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYDYAFISQGETTVASIDDAEELMATDNAFD 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   339 VLSFTAEEKAGVYKLTGAIMHYGNMKFKQKQREEQAEPDGTEDADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQSV 418
Cdd:cd14917  240 VLGFTSEEKNSMYKLTGAIMHFGNMKFKQKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNV 319
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   419 QQVYYSIGALAKSVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLE 498
Cdd:cd14917  320 QQVIYATGALAKAVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLE 399
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   499 QEEYKKEGIEWEFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKASDMTFKAKLYDNHLGKSNNFQKPRNVKGKQEAHF 578
Cdd:cd14917  400 QEEYKKEGIEWTFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLFDNHLGKSNNFQKPRNIKGKPEAHF 479
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   579 SLVHYAGTVDYNIMGWLEKNKDPLNETVVGLYQKSSLKLMATLFSTYASADtGDSGKGKGGKKKGSSFQTVSALHRENLN 658
Cdd:cd14917  480 SLIHYAGTVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSNLFANYAGAD-APIEKGKGKAKKGSSFQTVSALHRENLN 558
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   659 KLMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQFI 738
Cdd:cd14917  559 KLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQFI 638
                        650       660       670
                 ....*....|....*....|....*....|
gi 6754774   739 DSRKGAEKLLGSLDIDHNQYKFGHTKVFFK 768
Cdd:cd14917  639 DSRKGAEKLLSSLDIDHNQYKFGHTKVFFK 668
MYSc_Myh7b cd14927
class II myosin heavy chain 7b, motor domain; Myosin motor domain of cardiac muscle, beta ...
100-768 0e+00

class II myosin heavy chain 7b, motor domain; Myosin motor domain of cardiac muscle, beta myosin heavy chain 7b (also called KIAA1512, dJ756N5.1, MYH14, MHC14). MYH7B is a slow-twitch myosin. Mutations in this gene result in one form of autosomal dominant hearing impairment. Multiple transcript variants encoding different isoforms have been found for this gene. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276953 [Multi-domain]  Cd Length: 676  Bit Score: 1204.40  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   100 AVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGE 179
Cdd:cd14927    2 SVLHNLRRRYSRWMIYTYSGLFCVTVNPYKWLPVYTAPVVAAYKGKRRSEAPPHIYAIADNAYNDMLRNRENQSMLITGE 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   180 SGAGKTVNTKRVIQYFASIAAIGDRSKKENPNANK---GTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGAT 256
Cdd:cd14927   82 SGAGKTVNTKRVIQYFAIVAALGDGPGKKAQFLATktgGTLEDQIIEANPAMEAFGNAKTLRNDNSSRFGKFIRIHFGPT 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   257 GKLASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLDMLLVTNNPYDYAFVSQGEVSVASIDDSEELLATDSA 336
Cdd:cd14927  162 GKLASADIDIYLLEKSRVIFQQPGERSYHIYYQILSGKKPELQDMLLVSMNPYDYHFCSQGVTTVDNMDDGEELMATDHA 241
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   337 FDVLSFTAEEKAGVYKLTGAIMHYGNMKFKQKQREEQAEPDGTEDADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQ 416
Cdd:cd14927  242 MDILGFSPDEKYGCYKIVGAIMHFGNMKFKQKQREEQAEADGTESADKAAYLMGVSSADLLKGLLHPRVKVGNEYVTKGQ 321
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   417 SVQQVYYSIGALAKSVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFV 496
Cdd:cd14927  322 SVEQVVYAVGALAKATYDRMFKWLVSRINQTLDTKLPRQFFIGVLDIAGFEIFEFNSFEQLCINFTNEKLQQFFNHHMFI 401
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   497 LEQEEYKKEGIEWEFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKASDMTFKAKLYDNHLGKSNNFQKPR-NVKGKQE 575
Cdd:cd14927  402 LEQEEYKREGIEWVFIDFGLDLQACIDLIEKPLGILSILEEECMFPKASDASFKAKLYDNHLGKSPNFQKPRpDKKRKYE 481
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   576 AHFSLVHYAGTVDYNIMGWLEKNKDPLNETVVGLYQKSSLKLMATLFSTYASADTGD--SGKGKGGKKKGSSFQTVSALH 653
Cdd:cd14927  482 AHFEVVHYAGVVPYNIVGWLDKNKDPLNETVVAIFQKSQNKLLATLYENYVGSDSTEdpKSGVKEKRKKAASFQTVSQLH 561
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   654 RENLNKLMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIP 733
Cdd:cd14927  562 KENLNKLMTNLRATQPHFVRCIIPNETKTPGVMDPFLVLHQLRCNGVLEGIRICRKGFPNRILYADFKQRYRILNPSAIP 641
                        650       660       670
                 ....*....|....*....|....*....|....*
gi 6754774   734 EGQFIDSRKGAEKLLGSLDIDHNQYKFGHTKVFFK 768
Cdd:cd14927  642 DDKFVDSRKATEKLLGSLDIDHTQYQFGHTKVFFK 676
MYSc_Myh13 cd14923
class II myosin heavy chain 13, motor domain; Myosin motor domain of skeletal muscle myosin ...
99-768 0e+00

class II myosin heavy chain 13, motor domain; Myosin motor domain of skeletal muscle myosin heavy chain 13 (also called MyHC-eo) in mammals, chicken, and green anole. Myh13 is a myosin whose expression is restricted primarily to the extrinsic eye muscles which are specialized for function in eye movement. Class II myosins, also called conventional myosins, are the myosin type responsible for producing muscle contraction in muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276887 [Multi-domain]  Cd Length: 671  Bit Score: 1164.45  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    99 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITG 178
Cdd:cd14923    1 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVAAYRGKKRQEAPPHIFSISDNAYQFMLTDRDNQSILITG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   179 ESGAGKTVNTKRVIQYFASIAAIGDRSKKENPNANKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGK 258
Cdd:cd14923   81 ESGAGKTVNTKRVIQYFATIAVTGDKKKEQQPGKMQGTLEDQIIQANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGATGK 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   259 LASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLDMLLVTNNPYDYAFVSQGEVSVASIDDSEELLATDSAFD 338
Cdd:cd14923  161 LASADIETYLLEKSRVTFQLSSERSYHIFYQIMSNKKPELIDLLLISTNPFDFPFVSQGEVTVASIDDSEELLATDNAID 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   339 VLSFTAEEKAGVYKLTGAIMHYGNMKFKQKQREEQAEPDGTEDADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQSV 418
Cdd:cd14923  241 ILGFSSEEKVGIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAGYLMGLNSAEMLKGLCCPRVKVGNEYVTKGQNV 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   419 QQVYYSIGALAKSVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLE 498
Cdd:cd14923  321 QQVTNSVGALAKAVYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLE 400
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   499 QEEYKKEGIEWEFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKASDMTFKAKLYDNHLGKSNNFQKPRNVKGKQEAHF 578
Cdd:cd14923  401 QEEYKKEGIEWEFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQKPKPAKGKAEAHF 480
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   579 SLVHYAGTVDYNIMGWLEKNKDPLNETVVGLYQKSSLKLMATLFSTYASADTGDS-GKGKGGKKKGSSFQTVSALHRENL 657
Cdd:cd14923  481 SLVHYAGTVDYNIAGWLDKNKDPLNETVVGLYQKSSLKLLSFLFSNYAGAEAGDSgGSKKGGKKKGSSFQTVSAVFRENL 560
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   658 NKLMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQF 737
Cdd:cd14923  561 NKLMTNLRSTHPHFVRCLIPNETKTPGVMDHYLVMHQLRCNGVLEGIRICRKGFPSRILYADFKQRYRILNASAIPEGQF 640
                        650       660       670
                 ....*....|....*....|....*....|.
gi 6754774   738 IDSRKGAEKLLGSLDIDHNQYKFGHTKVFFK 768
Cdd:cd14923  641 IDSKNASEKLLNSIDVDREQYRFGHTKVFFK 671
MYSc_Myh8 cd14918
class II myosin heavy chain 8, motor domain; Myosin motor domain of perinatal skeletal muscle ...
99-768 0e+00

class II myosin heavy chain 8, motor domain; Myosin motor domain of perinatal skeletal muscle myosin heavy chain 8 (also called MyHC-peri, MyHC-pn). Myosin is a hexameric protein composed of a pair of myosin heavy chains (MYH) and two pairs of nonidentical light chains. A mutation in this gene results in trismus-pseudocamptodactyly syndrome. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276882 [Multi-domain]  Cd Length: 668  Bit Score: 1142.54  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    99 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITG 178
Cdd:cd14918    1 PGVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVAAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   179 ESGAGKTVNTKRVIQYFASIAAIGDRsKKENPNANKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGK 258
Cdd:cd14918   81 ESGAGKTVNTKRVIQYFATIAVTGEK-KKEESGKMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGK 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   259 LASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLDMLLVTNNPYDYAFVSQGEVSVASIDDSEELLATDSAFD 338
Cdd:cd14918  160 LASADIETYLLEKSRVTFQLKAERSYHIFYQITSNKKPDLIEMLLITTNPYDYAFVSQGEITVPSIDDQEELMATDSAID 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   339 VLSFTAEEKAGVYKLTGAIMHYGNMKFKQKQREEQAEPDGTEDADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQSV 418
Cdd:cd14918  240 ILGFTPEEKVSIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAAYLQSLNSADLLKALCYPRVKVGNEYVTKGQTV 319
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   419 QQVYYSIGALAKSVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLE 498
Cdd:cd14918  320 QQVYNAVGALAKAVYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLE 399
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   499 QEEYKKEGIEWEFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKASDMTFKAKLYDNHLGKSNNFQKPRNVKGKQEAHF 578
Cdd:cd14918  400 QEEYKKEGIEWTFIDFGMDLAACIELIEKPLGIFSILEEECMFPKATDTSFKNKLYDQHLGKSANFQKPKVVKGKAEAHF 479
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   579 SLVHYAGTVDYNIMGWLEKNKDPLNETVVGLYQKSSLKLMATLFSTYASADtGDSGKGKGGKKKGSSFQTVSALHRENLN 658
Cdd:cd14918  480 SLIHYAGTVDYNITGWLDKNKDPLNDTVVGLYQKSAMKTLASLFSTYASAE-ADSGAKKGAKKKGSSFQTVSALFRENLN 558
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   659 KLMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQFI 738
Cdd:cd14918  559 KLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYGDFKQRYKVLNASAIPEGQFI 638
                        650       660       670
                 ....*....|....*....|....*....|
gi 6754774   739 DSRKGAEKLLGSLDIDHNQYKFGHTKVFFK 768
Cdd:cd14918  639 DSKKASEKLLASIDIDHTQYKFGHTKVFFK 668
MYSc_Myh4 cd14915
class II myosin heavy chain 4, motor domain; Myosin motor domain of skeletal muscle myosin ...
99-768 0e+00

class II myosin heavy chain 4, motor domain; Myosin motor domain of skeletal muscle myosin heavy chain 4 (also called MYH2B, MyHC-2B, MyHC-IIb). Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276879 [Multi-domain]  Cd Length: 671  Bit Score: 1142.54  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    99 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITG 178
Cdd:cd14915    1 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVTAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   179 ESGAGKTVNTKRVIQYFASIAAIGDRSKKENPNAN-KGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATG 257
Cdd:cd14915   81 ESGAGKTVNTKRVIQYFATIAVTGEKKKEEAASGKmQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGATG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   258 KLASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLDMLLVTNNPYDYAFVSQGEVSVASIDDSEELLATDSAF 337
Cdd:cd14915  161 KLASADIETYLLEKSRVTFQLKAERSYHIFYQIMSNKKPELIEMLLITTNPYDFAFVSQGEITVPSIDDQEELMATDSAV 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   338 DVLSFTAEEKAGVYKLTGAIMHYGNMKFKQKQREEQAEPDGTEDADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQS 417
Cdd:cd14915  241 DILGFSADEKVAIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAAYLTSLNSADLLKALCYPRVKVGNEYVTKGQT 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   418 VQQVYYSIGALAKSVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVL 497
Cdd:cd14915  321 VQQVYNSVGALAKAIYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVL 400
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   498 EQEEYKKEGIEWEFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKASDMTFKAKLYDNHLGKSNNFQKPRNVKGKQEAH 577
Cdd:cd14915  401 EQEEYKKEGIEWEFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYEQHLGKSNNFQKPKPAKGKAEAH 480
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   578 FSLVHYAGTVDYNIMGWLEKNKDPLNETVVGLYQKSSLKLMATLFSTYASADTGDSGKGKGGKKKGSSFQTVSALHRENL 657
Cdd:cd14915  481 FSLVHYAGTVDYNIAGWLDKNKDPLNETVVGLYQKSGMKTLAFLFSGGQTAEAEGGGGKKGGKKKGSSFQTVSALFRENL 560
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   658 NKLMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQF 737
Cdd:cd14915  561 NKLMTNLRSTHPHFVRCLIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASAIPEGQF 640
                        650       660       670
                 ....*....|....*....|....*....|.
gi 6754774   738 IDSRKGAEKLLGSLDIDHNQYKFGHTKVFFK 768
Cdd:cd14915  641 IDSKKASEKLLGSIDIDHTQYKFGHTKVFFK 671
MYSc_Myh1_mammals cd14910
class II myosin heavy chain 1, motor domain; Myosin motor domain of type IIx skeletal muscle ...
99-768 0e+00

class II myosin heavy chain 1, motor domain; Myosin motor domain of type IIx skeletal muscle myosin heavy chain 1 (also called MYHSA1, MYHa, MyHC-2X/D, MGC133384) in mammals. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276875 [Multi-domain]  Cd Length: 671  Bit Score: 1139.84  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    99 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITG 178
Cdd:cd14910    1 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVTAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   179 ESGAGKTVNTKRVIQYFASIAAIGDRSKKENPNAN-KGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATG 257
Cdd:cd14910   81 ESGAGKTVNTKRVIQYFATIAVTGEKKKEEATSGKmQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   258 KLASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLDMLLVTNNPYDYAFVSQGEVSVASIDDSEELLATDSAF 337
Cdd:cd14910  161 KLASADIETYLLEKSRVTFQLKAERSYHIFYQIMSNKKPDLIEMLLITTNPYDYAFVSQGEITVPSIDDQEELMATDSAI 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   338 DVLSFTAEEKAGVYKLTGAIMHYGNMKFKQKQREEQAEPDGTEDADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQS 417
Cdd:cd14910  241 EILGFTSDERVSIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAAYLQNLNSADLLKALCYPRVKVGNEYVTKGQT 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   418 VQQVYYSIGALAKSVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVL 497
Cdd:cd14910  321 VQQVYNAVGALAKAVYDKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVL 400
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   498 EQEEYKKEGIEWEFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKASDMTFKAKLYDNHLGKSNNFQKPRNVKGKQEAH 577
Cdd:cd14910  401 EQEEYKKEGIEWEFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYEQHLGKSNNFQKPKPAKGKVEAH 480
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   578 FSLVHYAGTVDYNIMGWLEKNKDPLNETVVGLYQKSSLKLMATLFSTYASADTGDSGKGKGGKKKGSSFQTVSALHRENL 657
Cdd:cd14910  481 FSLIHYAGTVDYNIAGWLDKNKDPLNETVVGLYQKSSMKTLALLFSGAAAAEAEEGGGKKGGKKKGSSFQTVSALFRENL 560
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   658 NKLMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQF 737
Cdd:cd14910  561 NKLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASAIPEGQF 640
                        650       660       670
                 ....*....|....*....|....*....|.
gi 6754774   738 IDSRKGAEKLLGSLDIDHNQYKFGHTKVFFK 768
Cdd:cd14910  641 IDSKKASEKLLGSIDIDHTQYKFGHTKVFFK 671
MYSc_Myh2_mammals cd14912
class II myosin heavy chain 2, motor domain; Myosin motor domain of type IIa skeletal muscle ...
99-768 0e+00

class II myosin heavy chain 2, motor domain; Myosin motor domain of type IIa skeletal muscle myosin heavy chain 2 (also called MYH2A, MYHSA2, MyHC-IIa, MYHas8, MyHC-2A) in mammals. Mutations in this gene results in inclusion body myopathy-3 and familial congenital myopathy. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276877 [Multi-domain]  Cd Length: 673  Bit Score: 1116.35  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    99 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITG 178
Cdd:cd14912    1 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVTAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   179 ESGAGKTVNTKRVIQYFASIAAIGDRSKKENPNAN-KGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATG 257
Cdd:cd14912   81 ESGAGKTVNTKRVIQYFATIAVTGEKKKEEITSGKmQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   258 KLASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLDMLLVTNNPYDYAFVSQGEVSVASIDDSEELLATDSAF 337
Cdd:cd14912  161 KLASADIETYLLEKSRVTFQLKAERSYHIFYQITSNKKPELIEMLLITTNPYDYPFVSQGEISVASIDDQEELMATDSAI 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   338 DVLSFTAEEKAGVYKLTGAIMHYGNMKFKQKQREEQAEPDGTEDADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQS 417
Cdd:cd14912  241 DILGFTNEEKVSIYKLTGAVMHYGNLKFKQKQREEQAEPDGTEVADKAAYLQSLNSADLLKALCYPRVKVGNEYVTKGQT 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   418 VQQVYYSIGALAKSVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVL 497
Cdd:cd14912  321 VEQVTNAVGALAKAVYEKMFLWMVARINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVL 400
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   498 EQEEYKKEGIEWEFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKASDMTFKAKLYDNHLGKSNNFQKPRNVKGKQEAH 577
Cdd:cd14912  401 EQEEYKKEGIEWTFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYEQHLGKSANFQKPKVVKGKAEAH 480
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   578 FSLVHYAGTVDYNIMGWLEKNKDPLNETVVGLYQKSSLKLMATLFS--TYASADTGDSGKGKGGKKKGSSFQTVSALHRE 655
Cdd:cd14912  481 FSLIHYAGVVDYNITGWLDKNKDPLNETVVGLYQKSAMKTLAYLFSgaQTAEGASAGGGAKKGGKKKGSSFQTVSALFRE 560
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   656 NLNKLMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEG 735
Cdd:cd14912  561 NLNKLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASAIPEG 640
                        650       660       670
                 ....*....|....*....|....*....|...
gi 6754774   736 QFIDSRKGAEKLLGSLDIDHNQYKFGHTKVFFK 768
Cdd:cd14912  641 QFIDSKKASEKLLASIDIDHTQYKFGHTKVFFK 673
Myosin_head pfam00063
Myosin head (motor domain);
87-768 0e+00

Myosin head (motor domain);


Pssm-ID: 395017 [Multi-domain]  Cd Length: 674  Bit Score: 1081.15  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774      87 IEDMAMLTFLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYML 166
Cdd:pfam00063    1 VEDMVELSYLNEPSVLHNLKKRYKSDLIYTYSGLVLVAVNPYKQLPIYSEDMIKAYRGKRRGELPPHIFAIADEAYRSML 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     167 TDRENQSILITGESGAGKTVNTKRVIQYFASIAAIGDRSkkenpnaNKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFG 246
Cdd:pfam00063   81 QDKENQSILISGESGAGKTENTKKIMQYLASVSGSGSAG-------NVGRLEEQILQSNPILEAFGNAKTVRNNNSSRFG 153
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     247 KFIRIHFGATGKLASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLDMLLVTnNPYDYAFVSQ-GEVSVASID 325
Cdd:pfam00063  154 KYIEIQFDAKGDIVGGKIETYLLEKSRVVYQAEGERNYHIFYQLLAGASAQLKKELRLT-NPKDYHYLSQsGCYTIDGID 232
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     326 DSEELLATDSAFDVLSFTAEEKAGVYKLTGAIMHYGNMKFKQKQREEQAEPDGTEDADKSAYLMGLNSADLLKGLCHPRV 405
Cdd:pfam00063  233 DSEEFKITDKAMDILGFSDEEQMGIFRIVAAILHLGNIEFKKERNDEQAVPDDTENLQKAASLLGIDSTELEKALCKRRI 312
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     406 KVGNEYVTKGQSVQQVYYSIGALAKSVYEKMFNWMVTRINATLETKQ-PRQYFIGVLDIAGFEIFDFNSFEQLCINFTNE 484
Cdd:pfam00063  313 KTGRETVSKPQNVEQANYARDALAKAIYSRLFDWLVDRINKSLDVKTiEKASFIGVLDIYGFEIFEKNSFEQLCINYVNE 392
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     485 KLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGmDLQACIDLIE-KPMGIMSILEEECMFPKASDMTFKAKLYDNHlGKSNN 563
Cdd:pfam00063  393 KLQQFFNHHMFKLEQEEYVREGIEWTFIDFG-DNQPCIDLIEkKPLGILSLLDEECLFPKATDQTFLDKLYSTF-SKHPH 470
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     564 FQKPRNvkgKQEAHFSLVHYAGTVDYNIMGWLEKNKDPLNETVVGLYQKSSLKLMATLF---STYASADTGDSGKGKGGK 640
Cdd:pfam00063  471 FQKPRL---QGETHFIIKHYAGDVEYNVEGFLEKNKDPLNDDLVSLLKSSSDPLLAELFpdyETAESAAANESGKSTPKR 547
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     641 KKGSSFQTVSALHRENLNKLMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDF 720
Cdd:pfam00063  548 TKKKRFITVGSQFKESLGELMKTLNSTNPHYIRCIKPNEKKRAGVFDNSLVLHQLRCNGVLEGIRIRRAGFPNRITFQEF 627
                          650       660       670       680
                   ....*....|....*....|....*....|....*....|....*...
gi 6754774     721 RQRYRILNPAAIPEGqFIDSRKGAEKLLGSLDIDHNQYKFGHTKVFFK 768
Cdd:pfam00063  628 VQRYRILAPKTWPKW-KGDAKKGCEAILQSLNLDKEEYQFGKTKIFFR 674
MYSc_Myh15_mammals cd14929
class II myosin heavy chain 15, motor domain; Myosin motor domain of sarcomeric myosin heavy ...
99-768 0e+00

class II myosin heavy chain 15, motor domain; Myosin motor domain of sarcomeric myosin heavy chain 15 in mammals (also called KIAA1000) . MYH15 is a slow-twitch myosin. Myh15 is a ventricular myosin heavy chain. Myh15 is absent in embryonic and fetal muscles and is found in orbital layer of extraocular muscles at birth. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276892 [Multi-domain]  Cd Length: 662  Bit Score: 1067.67  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    99 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITG 178
Cdd:cd14929    1 ASVLHTLRRRYDHWMIYTYSGLFCVTINPYKWLPVYQKEVMAAYKGKRRSEAPPHIFAVANNAFQDMLHNRENQSILFTG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   179 ESGAGKTVNTKRVIQYFASIAAIGDRSKKEnpnankGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGK 258
Cdd:cd14929   81 ESGAGKTVNTKHIIQYFATIAAMIESKKKL------GALEDQIMQANPVLEAFGNAKTLRNDNSSRFGKFIRMHFGARGM 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   259 LASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKpELLDMLLVTNNPYDYAFVSQGEVSVASIDDSEELLATDSAFD 338
Cdd:cd14929  155 LSSADIDIYLLEKSRVIFQQPGERNYHIFYQILSGKK-ELRDLLLVSANPSDFHFCSCGAVAVESLDDAEELLATEQAMD 233
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   339 VLSFTAEEKAGVYKLTGAIMHYGNMKFKQKQREEQAEPDGTEDADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQSV 418
Cdd:cd14929  234 ILGFLPDEKYGCYKLTGAIMHFGNMKFKQKPREEQLEADGTENADKAAFLMGINSSELVKGLIHPRIKVGNEYVTRSQNI 313
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   419 QQVYYSIGALAKSVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLE 498
Cdd:cd14929  314 EQVTYAVGALSKSIYERMFKWLVARINRVLDAKLSRQFFIGILDITGFEILDYNSLEQLCINFTNEKLQQFFNQHMFVLE 393
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   499 QEEYKKEGIEWEFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKASDMTFKAKLYDNHLGKSNNFQKPRNVKGKQEAHF 578
Cdd:cd14929  394 QEEYRKEGIDWVSIDFGLDLQACIDLIEKPMGIFSILEEECMFPKATDLTFKTKLFDNHFGKSVHFQKPKPDKKKFEAHF 473
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   579 SLVHYAGTVDYNIMGWLEKNKDPLNETVVGLYQKSSLKLMATLFSTYASADTGdSGKGKGGKKKGSSFQTVSALHRENLN 658
Cdd:cd14929  474 ELVHYAGVVPYNISGWLEKNKDLLNETVVAVFQKSSNRLLASLFENYISTDSA-IQFGEKKRKKGASFQTVASLHKENLN 552
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   659 KLMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQFI 738
Cdd:cd14929  553 KLMTNLKSTAPHFVRCINPNVNKIPGVLDPYLVLQQLRCNGVLEGIRICREGFPNRLLYADFKQRYCILNPRTFPKSKFV 632
                        650       660       670
                 ....*....|....*....|....*....|
gi 6754774   739 DSRKGAEKLLGSLDIDHNQYKFGHTKVFFK 768
Cdd:cd14929  633 SSRKAAEELLGSLEIDHTQYRFGITKVFFK 662
MYSc smart00242
Myosin. Large ATPases; ATPase; molecular motor. Muscle contraction consists of a cyclical ...
80-780 0e+00

Myosin. Large ATPases; ATPase; molecular motor. Muscle contraction consists of a cyclical interaction between myosin and actin. The core of the myosin structure is similar in fold to that of kinesin.


Pssm-ID: 214580 [Multi-domain]  Cd Length: 677  Bit Score: 1018.24  E-value: 0e+00
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774       80 NPPKFDKIEDMAMLTFLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISD 159
Cdd:smart00242    1 NPPKFEGVEDLVLLTYLNEPAVLHNLKKRYLKDLIYTYIGLVLVAVNPYKQLPIYTDEVIKKYRGKSRGELPPHVFAIAD 80
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774      160 NAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFASIAAigdrskkenPNANKGTLEDQIIQANPALEAFGNAKTVRN 239
Cdd:smart00242   81 NAYRNMLNDKENQSIIISGESGAGKTENTKKIMQYLASVSG---------SNTEVGSVEDQILESNPILEAFGNAKTLRN 151
                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774      240 DNSSRFGKFIRIHFGATGKLASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLDMLLVTNnPYDYAFVSQG-E 318
Cdd:smart00242  152 NNSSRFGKFIEIHFDAKGKIIGAKIETYLLEKSRVVSQAKGERNYHIFYQLLAGASEELKKELGLKS-PEDYRYLNQGgC 230
                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774      319 VSVASIDDSEELLATDSAFDVLSFTAEEKAGVYKLTGAIMHYGNMKFKQKQREEQA-EPDGTEDADKSAYLMGLNSADLL 397
Cdd:smart00242  231 LTVDGIDDAEEFKETLNAMRVLGFSEEEQESIFKILAAILHLGNIEFEEGRNDNAAsTVKDKEELSNAAELLGVDPEELE 310
                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774      398 KGLCHPRVKVGNEYVTKGQSVQQVYYSIGALAKSVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQL 477
Cdd:smart00242  311 KALTKRKIKTGGEVITKPLNVEQALDARDALAKALYSRLFDWLVKRINQSLSFKDGSTYFIGVLDIYGFEIFEVNSFEQL 390
                           410       420       430       440       450       460       470       480
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774      478 CINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGmDLQACIDLIE-KPMGIMSILEEECMFPKASDMTFKAKLYdN 556
Cdd:smart00242  391 CINYANEKLQQFFNQHVFKLEQEEYEREGIDWTFIDFF-DNQDCIDLIEkKPPGILSLLDEECRFPKGTDQTFLEKLN-Q 468
                           490       500       510       520       530       540       550       560
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774      557 HLGKSNNFQKPRNvkgKQEAHFSLVHYAGTVDYNIMGWLEKNKDPLNETVVGLYQKSSLKLMATLFSTYASADTGDsgkg 636
Cdd:smart00242  469 HHKKHPHFSKPKK---KGRTEFIIKHYAGDVTYDVTGFLEKNKDTLSDDLIELLQSSKNPLIASLFPSGVSNAGSK---- 541
                           570       580       590       600       610       620       630       640
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774      637 kggkkkgSSFQTVSALHRENLNKLMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRIL 716
Cdd:smart00242  542 -------KRFQTVGSQFKEQLNELMDTLNSTNPHFIRCIKPNEEKKPGDFDSSLVLHQLRYLGVLENIRIRRAGFPYRLP 614
                           650       660       670       680       690       700
                    ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6754774      717 YGDFRQRYRILNPAAIPEGQFiDSRKGAEKLLGSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRD 780
Cdd:smart00242  615 FDEFLQRYRVLLPDTWPPWGG-DAKKACEALLQSLGLDEDEYQLGKTKVFLRPGQLAELEELRE 677
MYSc_Myh16 cd14934
class II myosin heavy chain 16, motor domain; Myosin motor domain of myosin heavy chain 16 ...
100-768 0e+00

class II myosin heavy chain 16, motor domain; Myosin motor domain of myosin heavy chain 16 pseudogene (also called MHC20, MYH16, and myh5), encoding a sarcomeric myosin heavy chain expressed in nonhuman primate masticatory muscles, is inactivated in humans. This cd contains Myh16 in mammals. MYH16 has intermediate fibres between that of slow type 1 and fast 2B fibres, but exert more force than any other fibre type examined. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. Some of the data used for this classification were produced by the CyMoBase team at the Max-Planck-Institute for Biophysical Chemistry. The sequence names are composed of the species abbreviation followed by the protein abbreviation and optional protein classifier and variant designations.


Pssm-ID: 276896 [Multi-domain]  Cd Length: 659  Bit Score: 1006.09  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   100 AVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGE 179
Cdd:cd14934    2 SVLDNLRQRYTNMRIYTYSGLFCVTVNPYKWLPIYGARVANMYKGKKRTEMPPHLFSISDNAYHDMLMDRENQSMLITGE 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   180 SGAGKTVNTKRVIQYFASIAAIGDRSKKenpnaNKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKL 259
Cdd:cd14934   82 SGAGKTENTKKVIQYFANIGGTGKQSSD-----GKGSLEDQIIQANPVLEAFGNAKTTRNNNSSRFGKFIRIHFGTTGKL 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   260 ASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLDMLLVTNNPYDYAFVSQGEVSVASIDDSEELLATDSAFDV 339
Cdd:cd14934  157 AGADIESYLLEKSRVISQQAAERGYHIFYQILSNKKPELIESLLLVPNPKEYHWVSQGVTVVDNMDDGEELQITDVAFDV 236
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   340 LSFTAEEKAGVYKLTGAIMHYGNMKFKQKQREEQAEPDGTEDADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQSVQ 419
Cdd:cd14934  237 LGFSAEEKIGVYKLTGGIMHFGNMKFKQKPREEQAEVDTTEVADKVAHLMGLNSGELQKGITRPRVKVGNEFVQKGQNME 316
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   420 QVYYSIGALAKSVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQ 499
Cdd:cd14934  317 QCNNSIGALGKAVYDKMFKWLVVRINKTLDTKMQRQFFIGVLDIAGFEIFEFNSFEQLCINFTNEKLQQFFNHHMFVLEQ 396
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   500 EEYKKEGIEWEFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKASDMTFKAKLYDNHLGKSNNFQKPRNVKGK-QEAHF 578
Cdd:cd14934  397 EEYKREGIEWVFIDFGLDLQACIDLLEKPMGIFSILEEQCVFPKATDATFKAALYDNHLGKSSNFLKPKGGKGKgPEAHF 476
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   579 SLVHYAGTVDYNIMGWLEKNKDPLNETVVGLYQKSSLkLMATLFSTYASADTGdsgkgKGGKKKGSSFQTVSALHRENLN 658
Cdd:cd14934  477 ELVHYAGTVGYNITGWLEKNKDPLNETVVGLFQKSSL-GLLALLFKEEEAPAG-----SKKQKRGSSFMTVSNFYREQLN 550
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   659 KLMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGqFI 738
Cdd:cd14934  551 KLMTTLHSTAPHFVRCIVPNEFKQSGVVDAHLIMHQLACNGVLEGIRICRKGFPNRLQYPEFKQRYQVLNPNVIPQG-FV 629
                        650       660       670
                 ....*....|....*....|....*....|
gi 6754774   739 DSRKGAEKLLGSLDIDHNQYKFGHTKVFFK 768
Cdd:cd14934  630 DNKKASELLLGSIDLDVNEYKIGHTKVFFR 659
MYSc_Myh1_insects_crustaceans cd14909
class II myosin heavy chain 1, motor domain; Myosin motor domain of type IIx skeletal muscle ...
99-768 0e+00

class II myosin heavy chain 1, motor domain; Myosin motor domain of type IIx skeletal muscle myosin heavy chain 1 (also called MYHSA1, MYHa, MyHC-2X/D, MGC133384) in insects and crustaceans. Myh1 is a type I skeletal muscle myosin that in Humans is encoded by the MYH1 gene. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276874  Cd Length: 666  Bit Score: 997.81  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    99 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITG 178
Cdd:cd14909    1 ASVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   179 ESGAGKTVNTKRVIQYFASIAAigdRSKKENPNANKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGK 258
Cdd:cd14909   81 ESGAGKTENTKKVIAYFATVGA---SKKTDEAAKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGK 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   259 LASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLDMLLVTNNPYDYAFVSQGEVSVASIDDSEELLATDSAFD 338
Cdd:cd14909  158 LAGADIETYLLEKARVISQQSLERSYHIFYQIMSGSVPGVKEMCLLSDNIYDYYIVSQGKVTVPNVDDGEEFSLTDQAFD 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   339 VLSFTAEEKAGVYKLTGAIMHYGNMKFKQKQREEQAEPDGTEDADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQSV 418
Cdd:cd14909  238 ILGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKNLLKPRIKVGNEFVTQGRNV 317
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   419 QQVYYSIGALAKSVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLE 498
Cdd:cd14909  318 QQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFEIFEYNGFEQLCINFTNEKLQQFFNHHMFVLE 397
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   499 QEEYKKEGIEWEFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKASDMTFKAKLYDNHLGKSNNFQKPRNVK-GKQEAH 577
Cdd:cd14909  398 QEEYKREGIDWAFIDFGMDLLACIDLIEKPMGILSILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKpGQQAAH 477
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   578 FSLVHYAGTVDYNIMGWLEKNKDPLNETVVGLYQKSSLKLMATLFSTYASADTGDSGKGKGGKKKGSSFQTVSALHRENL 657
Cdd:cd14909  478 FAIAHYAGCVSYNITGWLEKNKDPLNDTVVDQFKKSQNKLLIEIFADHAGQSGGGEQAKGGRGKKGGGFATVSSAYKEQL 557
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   658 NKLMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQf 737
Cdd:cd14909  558 NSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKILNPAGIQGEE- 636
                        650       660       670
                 ....*....|....*....|....*....|.
gi 6754774   738 iDSRKGAEKLLGSLDIDHNQYKFGHTKVFFK 768
Cdd:cd14909  637 -DPKKAAEIILESIALDPDQYRLGHTKVFFR 666
MYSc cd00124
Myosin motor domain superfamily; Myosin motor domain. The catalytic (head) domain has ATPase ...
99-768 0e+00

Myosin motor domain superfamily; Myosin motor domain. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276950 [Multi-domain]  Cd Length: 633  Bit Score: 840.33  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    99 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKR-SEAPPHIFSISDNAYQYMLTDRENQSILIT 177
Cdd:cd00124    1 AAILHNLRERYARDLIYTYVGDILVAVNPFKWLPLYSEEVMEKYRGKGRsADLPPHVFAVADAAYRAMLRDGQNQSILIS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   178 GESGAGKTVNTKRVIQYFASIAAigdrSKKENPNANKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATG 257
Cdd:cd00124   81 GESGAGKTETTKLVLKYLAALSG----SGSSKSSSSASSIEQQILQSNPILEAFGNAKTVRNDNSSRFGKFIELQFDPTG 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   258 KLASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLDML----LVTNNPYDYAFVSQGEVSVASIDDSEELLAT 333
Cdd:cd00124  157 RLVGASIETYLLEKSRVVSQAPGERNFHIFYQLLAGLSDGAREELklelLLSYYYLNDYLNSSGCDRIDGVDDAEEFQEL 236
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   334 DSAFDVLSFTAEEKAGVYKLTGAIMHYGNMKFKQKQREE--QAEPDGTEDADKSAYLMGLNSADLLKGLCHPRVKVGNEY 411
Cdd:cd00124  237 LDALDVLGFSDEEQDSIFRILAAILHLGNIEFEEDEEDEdsSAEVADDESLKAAAKLLGVDAEDLEEALTTRTIKVGGET 316
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   412 VTKGQSVQQVYYSIGALAKSVYEKMFNWMVTRINATL--ETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQF 489
Cdd:cd00124  317 ITKPLTVEQAEDARDALAKALYSRLFDWLVNRINAALspTDAAESTSFIGILDIFGFENFEVNSFEQLCINYANEKLQQF 396
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   490 FNHHMFVLEQEEYKKEGIEWEFIDFgMDLQACIDLIE-KPMGIMSILEEECMFPKASDMTFKAKLYDNHLGKSNNFQKPR 568
Cdd:cd00124  397 FNQHVFKLEQEEYEEEGIDWSFIDF-PDNQDCLDLIEgKPLGILSLLDEECLFPKGTDATFLEKLYSAHGSHPRFFSKKR 475
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   569 NVKGkqeaHFSLVHYAGTVDYNIMGWLEKNKDPLNETVVGLYQKSSlklmatlfstyasadtgdsgkgkggkkkgssfqt 648
Cdd:cd00124  476 KAKL----EFGIKHYAGDVTYDADGFLEKNKDTLPPDLVDLLRSGS---------------------------------- 517
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   649 vsaLHRENLNKLMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILN 728
Cdd:cd00124  518 ---QFRSQLDALMDTLNSTQPHFVRCIKPNDEKKPGLFDPELVLEQLRCAGVLEAVRIRRAGYPVRLPFDEFLKRYRILA 594
                        650       660       670       680
                 ....*....|....*....|....*....|....*....|
gi 6754774   729 PAAiPEGQFIDSRKGAEKLLGSLDIDHNQYKFGHTKVFFK 768
Cdd:cd00124  595 PGA-TEKASDSKKAAVLALLLLLKLDSSGYQLGKTKVFLR 633
COG5022 COG5022
Myosin heavy chain [General function prediction only];
31-1086 0e+00

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 840.12  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    31 FDIRTECFVPDDKEEYVKAKVVSRE--GGKVTAE--TENGKTVTIKEDQVMQ--QNPPKFDKIEDMAMLTFLHEPAVLYN 104
Cdd:COG5022    6 AEVGSGCWIPDEEKGWIWAEIIKEAfnKGKVTEEgkKEDGESVSVKKKVLGNdrIKLPKFDGVDDLTELSYLNEPAVLHN 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   105 LKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGESGAGK 184
Cdd:COG5022   86 LEKRYNNGQIYTYSGLVLIAVNPYRDLGIYTDDIIQSYSGKNRLELEPHVFAIAEEAYRNLLSEKENQTIIISGESGAGK 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   185 TVNTKRVIQYFASIAAigdrskkeNPNANKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADI 264
Cdd:COG5022  166 TENAKRIMQYLASVTS--------SSTVEISSIEKQILATNPILEAFGNAKTVRNDNSSRFGKYIKIEFDENGEICGAKI 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   265 ETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLDMLLVTNnPYDYAFVSQGEV-SVASIDDSEELLATDSAFDVLSFT 343
Cdd:COG5022  238 ETYLLEKSRVVHQNKNERNYHIFYQLLAGDPEELKKLLLLQN-PKDYIYLSQGGCdKIDGIDDAKEFKITLDALKTIGID 316
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   344 AEEKAGVYKLTGAIMHYGNMKFKqKQREEQAEPDGTEDADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQSVQQVYY 423
Cdd:COG5022  317 EEEQDQIFKILAAILHIGNIEFK-EDRNGAAIFSDNSVLDKACYLLGIDPSLFVKWLVKRQIKTGGEWIVVPLNLEQALA 395
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   424 SIGALAKSVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYK 503
Cdd:COG5022  396 IRDSLAKALYSNLFDWIVDRINKSLDHSAAASNFIGVLDIYGFEIFEKNSFEQLCINYTNEKLQQFFNQHMFKLEQEEYV 475
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   504 KEGIEWEFIDFgMDLQACIDLIEK--PMGIMSILEEECMFPKASDMTFKAKLYDN-HLGKSNNFQKPRNVKGKqeahFSL 580
Cdd:COG5022  476 KEGIEWSFIDY-FDNQPCIDLIEKknPLGILSLLDEECVMPHATDESFTSKLAQRlNKNSNPKFKKSRFRDNK----FVV 550
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   581 VHYAGTVDYNIMGWLEKNKDPLNETVVGLYQKSSLKLMATLFSTYASADTgdsgkgkggkkkGSSFQTVSALHRENLNKL 660
Cdd:COG5022  551 KHYAGDVEYDVEGFLDKNKDPLNDDLLELLKASTNEFVSTLFDDEENIES------------KGRFPTLGSRFKESLNSL 618
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   661 MTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQFI-- 738
Cdd:COG5022  619 MSTLNSTQPHYIRCIKPNEEKSPWTFDNQMVLSQLRCCGVLETIRISRAGFPSRWTFDEFVQRYRILSPSKSWTGEYTwk 698
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   739 -DSRKGAEKLLGSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRDERLSRIITRIQAQARGQLMRIEFKKIVERRDALLVIQ 817
Cdd:COG5022  699 eDTKNAVKSILEELVIDSSKYQIGNTKVFFKAGVLAALEDMRDAKLDNIATRIQRAIRGRYLRRRYLQALKRIKKIQVIQ 778
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   818 WNIRAFMGVKNWPWMKLYFKIKPLLKSAETEKEM---------------------ANMKEEFGRVKDALeKSEARRKELE 876
Cdd:COG5022  779 HGFRLRRLVDYELKWRLFIKLQPLLSLLGSRKEYrsylaciiklqktikrekklrETEEVEFSLKAEVL-IQKFGRSLKA 857
                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   877 EKMVSLLQEKNdLQLQVQAEQDN-------LNDAEERCDQL-----------------------IKNKIQLE--AKVKEM 924
Cdd:COG5022  858 KKRFSLLKKET-IYLQSAQRVELaerqlqeLKIDVKSISSLklvnleleseiielkkslssdliENLEFKTEliARLKKL 936
                        970       980       990      1000      1010      1020      1030      1040
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   925 TE--RLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLakveKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQ 1002
Cdd:COG5022  937 LNniDLEEGPSIEYVKLPELNKLHEVESKLKETSEEYEDLL----KKSTILVREGNKANSELKNFKKELAELSKQYGALQ 1012
                       1050      1060      1070      1080      1090      1100      1110      1120
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1003 EAHQQ------ALDDLQAEEDKVNTLTKSKvKLEQQVDDLEGSLEQEKK------VRMDLERAKRKLEGDLKLTQESIMD 1070
Cdd:COG5022 1013 ESTKQlkelpvEVAELQSASKIISSESTEL-SILKPLQKLKGLLLLENNqlqaryKALKLRRENSLLDDKQLYQLESTEN 1091
                       1130
                 ....*....|....*.
gi 6754774  1071 LENDKLQLEEKLKKKE 1086
Cdd:COG5022 1092 LLKTINVKDLEVTNRN 1107
MYSc_Myh2_insects_mollusks cd14911
class II myosin heavy chain 2, motor domain; Myosin motor domain of type IIa skeletal muscle ...
100-768 0e+00

class II myosin heavy chain 2, motor domain; Myosin motor domain of type IIa skeletal muscle myosin heavy chain 2 (also called MYH2A, MYHSA2, MyHC-IIa, MYHas8, MyHC-2A) in insects and mollusks. This gene encodes a member of the class II or conventional myosin heavy chains, and functions in skeletal muscle contraction. Mutations in this gene results in inclusion body myopathy-3 and familial congenital myopathy. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276876 [Multi-domain]  Cd Length: 674  Bit Score: 794.18  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   100 AVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGE 179
Cdd:cd14911    2 SVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLPIYTEKIMERYKGIKRHEVPPHVFAITDSAYRNMLGDREDQSILCTGE 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   180 SGAGKTVNTKRVIQYFASIAAIGDRS------KKENPNANKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHF 253
Cdd:cd14911   82 SGAGKTENTKKVIQFLAYVAASKPKGsgavphPAVNPAVLIGELEQQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINF 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   254 GATGKLASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLDMLLVtNNPYDYAFVSQGEVSVASIDDSEELLAT 333
Cdd:cd14911  162 DASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLLAGATPEQREKFIL-DDVKSYAFLSNGSLPVPGVDDYAEFQAT 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   334 DSAFDVLSFTAEEKAGVYKLTGAIMHYGNMKFKQKQREEQAE-PDGTEdADKSAYLMGLNSADLLKGLCHPRVKVGNEYV 412
Cdd:cd14911  241 VKSMNIMGMTSEDFNSIFRIVSAVLLFGSMKFRQERNNDQATlPDNTV-AQKIAHLLGLSVTDMTRAFLTPRIKVGRDFV 319
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   413 TKGQSVQQVYYSIGALAKSVYEKMFNWMVTRINATLE-TKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFN 491
Cdd:cd14911  320 TKAQTKEQVEFAVEAIAKACYERMFKWLVNRINRSLDrTKRQGASFIGILDMAGFEIFELNSFEQLCINYTNEKLQQLFN 399
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   492 HHMFVLEQEEYKKEGIEWEFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKASDMTFKAKLYDNHLgksnnfQKPRNVK 571
Cdd:cd14911  400 HTMFILEQEEYQREGIEWKFIDFGLDLQPTIDLIDKPGGIMALLDEECWFPKATDKTFVDKLVSAHS------MHPKFMK 473
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   572 G--KQEAHFSLVHYAGTVDYNIMGWLEKNKDPLNETVVGLYQKSSLKLMATLFSTYASADTGDSGKGKGG---KKKGSSF 646
Cdd:cd14911  474 TdfRGVADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLLQGSQDPFVVNIWKDAEIVGMAQQALTDTQfgaRTRKGMF 553
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   647 QTVSALHRENLNKLMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRI 726
Cdd:cd14911  554 RTVSHLYKEQLAKLMDTLRNTNPNFVRCIIPNHEKRAGKIDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQRYEL 633
                        650       660       670       680
                 ....*....|....*....|....*....|....*....|..
gi 6754774   727 LNPAAIPEGqFIDSRKGAEKLLGSLDIDHNQYKFGHTKVFFK 768
Cdd:cd14911  634 LTPNVIPKG-FMDGKKACEKMIQALELDSNLYRVGQSKIFFR 674
MYSc_Myh10 cd14920
class II myosin heavy chain 10, motor domain; Myosin motor domain of non-muscle myosin heavy ...
100-768 0e+00

class II myosin heavy chain 10, motor domain; Myosin motor domain of non-muscle myosin heavy chain 10 (also called NMMHCB). Mutations in this gene have been associated with May-Hegglin anomaly and developmental defects in brain and heart. Multiple transcript variants encoding different isoforms have been found for this gene. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276952 [Multi-domain]  Cd Length: 673  Bit Score: 757.24  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   100 AVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGE 179
Cdd:cd14920    2 SVLHNLKDRYYSGLIYTYSGLFCVVINPYKNLPIYSENIIEMYRGKKRHEMPPHIYAISESAYRCMLQDREDQSILCTGE 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   180 SGAGKTVNTKRVIQYFASIAAigdRSKKENPNANKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKL 259
Cdd:cd14920   82 SGAGKTENTKKVIQYLAHVAS---SHKGRKDHNIPGELERQLLQANPILESFGNAKTVKNDNSSRFGKFIRINFDVTGYI 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   260 ASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPEL-LDMLLVTNNpyDYAFVSQGEVSVASIDDSEELLATDSAFD 338
Cdd:cd14920  159 VGANIETYLLEKSRAVRQAKDERTFHIFYQLLSGAGEHLkSDLLLEGFN--NYRFLSNGYIPIPGQQDKDNFQETMEAMH 236
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   339 VLSFTAEEKAGVYKLTGAIMHYGNMKFKQKQREEQAE-PDGTEdADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQS 417
Cdd:cd14920  237 IMGFSHEEILSMLKVVSSVLQFGNISFKKERNTDQASmPENTV-AQKLCHLLGMNVMEFTRAILTPRIKVGRDYVQKAQT 315
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   418 VQQVYYSIGALAKSVYEKMFNWMVTRINATLETKQpRQ--YFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMF 495
Cdd:cd14920  316 KEQADFAVEALAKATYERLFRWLVHRINKALDRTK-RQgaSFIGILDIAGFEIFELNSFEQLCINYTNEKLQQLFNHTMF 394
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   496 VLEQEEYKKEGIEWEFIDFGMDLQACIDLIEKPM---GIMSILEEECMFPKASDMTFKAKLyDNHLGKSNNFQKPRNVKG 572
Cdd:cd14920  395 ILEQEEYQREGIEWNFIDFGLDLQPCIDLIERPAnppGVLALLDEECWFPKATDKTFVEKL-VQEQGSHSKFQKPRQLKD 473
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   573 kqEAHFSLVHYAGTVDYNIMGWLEKNKDPLNETVVGLYQKSSLKLMATLFSTY-----ASADTG--DSGKGKGGKKKGSS 645
Cdd:cd14920  474 --KADFCIIHYAGKVDYKADEWLMKNMDPLNDNVATLLHQSSDRFVAELWKDVdrivgLDQVTGmtETAFGSAYKTKKGM 551
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   646 FQTVSALHRENLNKLMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYR 725
Cdd:cd14920  552 FRTVGQLYKESLTKLMATLRNTNPNFVRCIIPNHEKRAGKLDPHLVLDQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYE 631
                        650       660       670       680
                 ....*....|....*....|....*....|....*....|...
gi 6754774   726 ILNPAAIPEGqFIDSRKGAEKLLGSLDIDHNQYKFGHTKVFFK 768
Cdd:cd14920  632 ILTPNAIPKG-FMDGKQACERMIRALELDPNLYRIGQSKIFFR 673
MYSc_Myh18 cd14932
class II myosin heavy chain 18, motor domain; Myosin motor domain of muscle myosin heavy chain ...
100-768 0e+00

class II myosin heavy chain 18, motor domain; Myosin motor domain of muscle myosin heavy chain 18. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276895 [Multi-domain]  Cd Length: 676  Bit Score: 710.26  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   100 AVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGE 179
Cdd:cd14932    2 SVLHNLKERYYSGLIYTYSGLFCVVINPYKYLPIYSEEIVNMYKGKKRHEMPPHIYAITDTAYRSMMQDREDQSILCTGE 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   180 SGAGKTVNTKRVIQYFASIAAiGDRSKKENPNA--NKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATG 257
Cdd:cd14932   82 SGAGKTENTKKVIQYLAYVAS-SFKTKKDQSSIalSHGELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVNG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   258 KLASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLDMLLVTNNPyDYAFVSQGEVSVASIDDSEELLATDSAF 337
Cdd:cd14932  161 YIVGANIETYLLEKSRAIRQAKDERAFHIFYYLLTGAGDKLRSELCLEDYS-KYRFLSNGNVTIPGQQDKELFAETMEAF 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   338 DVLSFTAEEKAGVYKLTGAIMHYGNMKFKQKQREEQAE-PDGTEdADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQ 416
Cdd:cd14932  240 RIMSIPEEEQTGLLKVVSAVLQLGNMSFKKERNSDQASmPDDTA-AQKVCHLLGMNVTDFTRAILSPRIKVGRDYVQKAQ 318
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   417 SVQQVYYSIGALAKSVYEKMFNWMVTRINATLE-TKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMF 495
Cdd:cd14932  319 TQEQAEFAVEALAKASYERMFRWLVMRINKALDkTKRQGASFIGILDIAGFEIFELNSFEQLCINYTNEKLQQLFNHTMF 398
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   496 VLEQEEYKKEGIEWEFIDFGMDLQACIDLIEKPM---GIMSILEEECMFPKASDMTFKAKLYdNHLGKSNNFQKPRnvKG 572
Cdd:cd14932  399 ILEQEEYQREGIEWSFIDFGLDLQPCIELIEKPNgppGILALLDEECWFPKATDKSFVEKVV-QEQGNNPKFQKPK--KL 475
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   573 KQEAHFSLVHYAGTVDYNIMGWLEKNKDPLNETVVGLYQKSSLKLMATLFSTY-------ASADTGDsGKGKGGKKKGSS 645
Cdd:cd14932  476 KDDADFCIIHYAGKVDYKANEWLMKNMDPLNENVATLLNQSTDKFVSELWKDVdrivgldKVAGMGE-SLHGAFKTRKGM 554
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   646 FQTVSALHRENLNKLMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYR 725
Cdd:cd14932  555 FRTVGQLYKEQLMNLMTTLRNTNPNFVRCIIPNHEKKAGKLAHHLVLDQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYE 634
                        650       660       670       680
                 ....*....|....*....|....*....|....*....|...
gi 6754774   726 ILNPAAIPEGqFIDSRKGAEKLLGSLDIDHNQYKFGHTKVFFK 768
Cdd:cd14932  635 ILTPNAIPKG-FMDGKQACVLMVKALELDPNLYRIGQSKVFFR 676
MYSc_Myo5 cd01380
class V myosin, motor domain; Myo5, also called heavy chain 12, myoxin, are dimeric myosins ...
99-768 0e+00

class V myosin, motor domain; Myo5, also called heavy chain 12, myoxin, are dimeric myosins that transport a variety of intracellular cargo processively along actin filaments, such as melanosomes, synaptic vesicles, vacuoles, and mRNA. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. It also contains a IQ domain and a globular DIL domain. Myosin V is a class of actin-based motor proteins involved in cytoplasmic vesicle transport and anchorage, spindle-pole alignment and mRNA translocation. The protein encoded by this gene is abundant in melanocytes and nerve cells. Mutations in this gene cause Griscelli syndrome type-1 (GS1), Griscelli syndrome type-3 (GS3) and neuroectodermal melanolysosomal disease, or Elejalde disease. Multiple alternatively spliced transcript variants encoding different isoforms have been reported, but the full-length nature of some variants has not been determined. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. Note that the Dictyostelium myoVs are not contained in this child group. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276831 [Multi-domain]  Cd Length: 629  Bit Score: 695.44  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    99 PAVLYNLKERYA-AWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILIT 177
Cdd:cd01380    1 PAVLHNLKVRFCqRNAIYTYCGIVLVAINPYEDLPIYGEDIIQAYSGQNMGELDPHIFAIAEEAYRQMARDEKNQSIIVS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   178 GESGAGKTVNTKRVIQYFASIAAigdrskkenPNANKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATG 257
Cdd:cd01380   81 GESGAGKTVSAKYAMRYFATVGG---------SSSGETQVEEKVLASNPIMEAFGNAKTTRNDNSSRFGKYIEILFDKNY 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   258 KLASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLDMLLVTNNPYDYAFVSQGEVSVASIDDSEELLATDSAF 337
Cdd:cd01380  152 RIIGANMRTYLLEKSRVVFQAEEERNYHIFYQLCAAASLPELKELHLGSAEDFFYTNQGGSPVIDGVDDAAEFEETRKAL 231
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   338 DVLSFTAEEKAGVYKLTGAIMHYGNMKFKQKQREEQAEPDGTEDADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQS 417
Cdd:cd01380  232 TLLGISEEEQMEIFRILAAILHLGNVEIKATRNDSASISPDDEHLQIACELLGIDESQLAKWLCKRKIVTRSEVIVKPLT 311
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   418 VQQVYYSIGALAKSVYEKMFNWMVTRINATLETKQP--RQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMF 495
Cdd:cd01380  312 LQQAIVARDALAKHIYAQLFDWIVDRINKALASPVKekQHSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQHVF 391
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   496 VLEQEEYKKEGIEWEFIDFgMDLQACIDLIEKPMGIMSILEEECMFPKASDMTFKAKLYDNHLGKSNN-FQKPRNVKGKq 574
Cdd:cd01380  392 KLEQEEYVKEEIEWSFIDF-YDNQPCIDLIEGKLGILDLLDEECRLPKGSDENWAQKLYNQHLKKPNKhFKKPRFSNTA- 469
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   575 eahFSLVHYAGTVDYNIMGWLEKNKDPLNETVVGLYQKSSLKLMatlfstyasadtgdsgkgkggkkkgssfqTVSALHR 654
Cdd:cd01380  470 ---FIVKHFADDVEYQVEGFLEKNRDTVSEEHLNVLKASKNRKK-----------------------------TVGSQFR 517
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   655 ENLNKLMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAipE 734
Cdd:cd01380  518 DSLILLMETLNSTTPHYVRCIKPNDEKLPFTFDPKRVVQQLRACGVLETIRISAAGFPSRWTYEEFFSRYRVLLPSK--E 595
                        650       660       670
                 ....*....|....*....|....*....|....
gi 6754774   735 GQFIDSRKGAEKLLGSLDIDHNQYKFGHTKVFFK 768
Cdd:cd01380  596 WLRDDKKKTCENILENLILDPDKYQFGKTKIFFR 629
MYSc_Myh11 cd14921
class II myosin heavy chain 11, motor domain; Myosin motor domain of smooth muscle myosin ...
100-768 0e+00

class II myosin heavy chain 11, motor domain; Myosin motor domain of smooth muscle myosin heavy chain 11 (also called SMMHC, SMHC). The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. The gene encoding a human ortholog of rat NUDE1 is transcribed from the reverse strand of this gene, and its 3' end overlaps with that of the latter. Inversion of the MYH11 locus is one of the most frequent chromosomal aberrations found in acute myeloid leukemia. Alternative splicing generates isoforms that are differentially expressed, with ratios changing during muscle cell maturation. Mutations in MYH11 have been described in individuals with thoracic aortic aneurysms leading to acute aortic dissections with patent ductus arteriosus. MYH11 mutations are also thought to contribute to human colorectal cancer and are also associated with Peutz-Jeghers syndrome. The mutations found in human intestinal neoplasia result in unregulated proteins with constitutive motor activity, similar to the mutant myh11 zebrafish. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276885 [Multi-domain]  Cd Length: 673  Bit Score: 681.74  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   100 AVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGE 179
Cdd:cd14921    2 SVLHNLRERYFSGLIYTYSGLFCVVVNPYKHLPIYSEKIVDMYKGKKRHEMPPHIYAIADTAYRSMLQDREDQSILCTGE 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   180 SGAGKTVNTKRVIQYFASIAAigdRSKKENPNANKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKL 259
Cdd:cd14921   82 SGAGKTENTKKVIQYLAVVAS---SHKGKKDTSITGELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVTGYI 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   260 ASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELL-DMLLVTNNpyDYAFVSQGEVSVASIDDSEELLATDSAFD 338
Cdd:cd14921  159 VGANIETYLLEKSRAIRQARDERTFHIFYYLIAGAKEKMRsDLLLEGFN--NYTFLSNGFVPIPAAQDDEMFQETLEAMS 236
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   339 VLSFTAEEKAGVYKLTGAIMHYGNMKFKQKQREEQAE-PDGTEdADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQS 417
Cdd:cd14921  237 IMGFSEEEQLSILKVVSSVLQLGNIVFKKERNTDQASmPDNTA-AQKVCHLMGINVTDFTRSILTPRIKVGRDVVQKAQT 315
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   418 VQQVYYSIGALAKSVYEKMFNWMVTRINATLE-TKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFV 496
Cdd:cd14921  316 KEQADFAIEALAKATYERLFRWILTRVNKALDkTHRQGASFLGILDIAGFEIFEVNSFEQLCINYTNEKLQQLFNHTMFI 395
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   497 LEQEEYKKEGIEWEFIDFGMDLQACIDLIEKPM---GIMSILEEECMFPKASDMTFKAKLYDNHlGKSNNFQKPRNVKGK 573
Cdd:cd14921  396 LEQEEYQREGIEWNFIDFGLDLQPCIELIERPNnppGVLALLDEECWFPKATDKSFVEKLCTEQ-GNHPKFQKPKQLKDK 474
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   574 QEahFSLVHYAGTVDYNIMGWLEKNKDPLNETVVGLYQKSSLKLMATLFSTY-------ASADTGDSGKGKGGKKKGSSF 646
Cdd:cd14921  475 TE--FSIIHYAGKVDYNASAWLTKNMDPLNDNVTSLLNASSDKFVADLWKDVdrivgldQMAKMTESSLPSASKTKKGMF 552
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   647 QTVSALHRENLNKLMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRI 726
Cdd:cd14921  553 RTVGQLYKEQLGKLMTTLRNTTPNFVRCIIPNHEKRSGKLDAFLVLEQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEI 632
                        650       660       670       680
                 ....*....|....*....|....*....|....*....|..
gi 6754774   727 LNPAAIPEGqFIDSRKGAEKLLGSLDIDHNQYKFGHTKVFFK 768
Cdd:cd14921  633 LAANAIPKG-FMDGKQACILMIKALELDPNLYRIGQSKIFFR 673
MYSc_Myh9 cd14919
class II myosin heavy chain 9, motor domain; Myosin motor domain of non-muscle myosin heavy ...
100-768 0e+00

class II myosin heavy chain 9, motor domain; Myosin motor domain of non-muscle myosin heavy chain 9 (also called NMMHCA, NMHC-II-A, MHA, FTNS, EPSTS, and DFNA17). Myosin is a hexameric protein composed of a pair of myosin heavy chains (MYH) and two pairs of nonidentical light chains. The encoded protein is a myosin IIA heavy chain that contains an IQ domain and a myosin head-like domain which is involved in several important functions, including cytokinesis, cell motility and maintenance of cell shape. Defects in this gene have been associated with non-syndromic sensorineural deafness autosomal dominant type 17, Epstein syndrome, Alport syndrome with macrothrombocytopenia, Sebastian syndrome, Fechtner syndrome and macrothrombocytopenia with progressive sensorineural deafness. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276883 [Multi-domain]  Cd Length: 670  Bit Score: 673.34  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   100 AVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGE 179
Cdd:cd14919    2 SVLHNLKERYYSGLIYTYSGLFCVVINPYKNLPIYSEEIVEMYKGKKRHEMPPHIYAITDTAYRSMMQDREDQSILCTGE 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   180 SGAGKTVNTKRVIQYFASIAAiGDRSKKEnpnanKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKL 259
Cdd:cd14919   82 SGAGKTENTKKVIQYLAHVAS-SHKSKKD-----QGELERQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVNGYI 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   260 ASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLDMLLVtnNPYD-YAFVSQGEVSVASIDDSEELLATDSAFD 338
Cdd:cd14919  156 VGANIETYLLEKSRAIRQAKEERTFHIFYYLLSGAGEHLKTDLLL--EPYNkYRFLSNGHVTIPGQQDKDMFQETMEAMR 233
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   339 VLSFTAEEKAGVYKLTGAIMHYGNMKFKQKQREEQAE-PDGTEdADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQS 417
Cdd:cd14919  234 IMGIPEEEQMGLLRVISGVLQLGNIVFKKERNTDQASmPDNTA-AQKVSHLLGINVTDFTRGILTPRIKVGRDYVQKAQT 312
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   418 VQQVYYSIGALAKSVYEKMFNWMVTRINATLE-TKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFV 496
Cdd:cd14919  313 KEQADFAIEALAKATYERMFRWLVLRINKALDkTKRQGASFIGILDIAGFEIFDLNSFEQLCINYTNEKLQQLFNHTMFI 392
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   497 LEQEEYKKEGIEWEFIDFGMDLQACIDLIEKPM---GIMSILEEECMFPKASDMTFKAKLYDNHlGKSNNFQKPRNVKGK 573
Cdd:cd14919  393 LEQEEYQREGIEWNFIDFGLDLQPCIDLIEKPAgppGILALLDEECWFPKATDKSFVEKVVQEQ-GTHPKFQKPKQLKDK 471
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   574 qeAHFSLVHYAGTVDYNIMGWLEKNKDPLNETVVGLYQKSSLKLMATLFSTY-------ASADTGDSGKGKGGKKKGSSF 646
Cdd:cd14919  472 --ADFCIIHYAGKVDYKADEWLMKNMDPLNDNIATLLHQSSDKFVSELWKDVdriigldQVAGMSETALPGAFKTRKGMF 549
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   647 QTVSALHRENLNKLMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRI 726
Cdd:cd14919  550 RTVGQLYKEQLAKLMATLRNTNPNFVRCIIPNHEKKAGKLDPHLVLDQLRCNGVLEGIRICRQGFPNRVVFQEFRQRYEI 629
                        650       660       670       680
                 ....*....|....*....|....*....|....*....|..
gi 6754774   727 LNPAAIPEGqFIDSRKGAEKLLGSLDIDHNQYKFGHTKVFFK 768
Cdd:cd14919  630 LTPNSIPKG-FMDGKQACVLMIKALELDSNLYRIGQSKVFFR 670
MYSc_Myh19 cd15896
class II myosin heavy chain19, motor domain; Myosin motor domain of muscle myosin heavy chain ...
100-768 0e+00

class II myosin heavy chain19, motor domain; Myosin motor domain of muscle myosin heavy chain 19. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276899 [Multi-domain]  Cd Length: 675  Bit Score: 671.78  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   100 AVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGE 179
Cdd:cd15896    2 SVLHNLKERYYSGLIYTYSGLFCVVINPYKNLPIYSEEIVEMYKGKKRHEMPPHIYAITDTAYRSMMQDREDQSILCTGE 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   180 SGAGKTVNTKRVIQYFASIAAiGDRSKKENPN--ANKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATG 257
Cdd:cd15896   82 SGAGKTENTKKVIQYLAHVAS-SHKTKKDQNSlaLSHGELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVNG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   258 KLASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLDMLLVTNNPyDYAFVSQGEVSVASIDDSEELLATDSAF 337
Cdd:cd15896  161 YIVGANIETYLLEKSRAIRQAKEERTFHIFYYLLTGAGDKLRSELLLENYN-NYRFLSNGNVTIPGQQDKDLFTETMEAF 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   338 DVLSFTAEEKAGVYKLTGAIMHYGNMKFKQKQREEQAE-PDGTEdADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQ 416
Cdd:cd15896  240 RIMGIPEDEQIGMLKVVASVLQLGNMSFKKERHTDQASmPDNTA-AQKVCHLMGMNVTDFTRAILSPRIKVGRDYVQKAQ 318
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   417 SVQQVYYSIGALAKSVYEKMFNWMVTRINATLE-TKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMF 495
Cdd:cd15896  319 TQEQAEFAVEALAKATYERMFRWLVMRINKALDkTKRQGASFIGILDIAGFEIFELNSFEQLCINYTNEKLQQLFNHTMF 398
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   496 VLEQEEYKKEGIEWEFIDFGMDLQACIDLIEKPM---GIMSILEEECMFPKASDMTFKAKLYDNHlGKSNNFQKPRnvKG 572
Cdd:cd15896  399 ILEQEEYQREGIEWSFIDFGLDLQPCIDLIEKPAsppGILALLDEECWFPKATDKSFVEKVLQEQ-GTHPKFFKPK--KL 475
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   573 KQEAHFSLVHYAGTVDYNIMGWLEKNKDPLNETVVGLYQKSSLKLMATLFSTYAS-----ADTGDSGKGKGGKKKGSSFQ 647
Cdd:cd15896  476 KDEADFCIIHYAGKVDYKADEWLMKNMDPLNDNVATLLNQSTDKFVSELWKDVDRivgldKVSGMSEMPGAFKTRKGMFR 555
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   648 TVSALHRENLNKLMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRIL 727
Cdd:cd15896  556 TVGQLYKEQLSKLMATLRNTNPNFVRCIIPNHEKKAGKLDPHLVLDQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEIL 635
                        650       660       670       680
                 ....*....|....*....|....*....|....*....|.
gi 6754774   728 NPAAIPEGqFIDSRKGAEKLLGSLDIDHNQYKFGHTKVFFK 768
Cdd:cd15896  636 TPNAIPKG-FMDGKQACVLMIKSLELDPNLYRIGQSKVFFR 675
MYSc_Myh14_mammals cd14930
class II myosin heavy chain 14 motor domain; Myosin motor domain of non-muscle myosin heavy ...
100-768 0e+00

class II myosin heavy chain 14 motor domain; Myosin motor domain of non-muscle myosin heavy chain 14 (also called FLJ13881, KIAA2034, MHC16, MYH17). Its members include mammals, chickens, and turtles. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. Some of the data used for this classification were produced by the CyMoBase team at the Max-Planck-Institute for Biophysical Chemistry. The sequence names are composed of the species abbreviation followed by the protein abbreviation and optional protein classifier and variant designations.


Pssm-ID: 276893 [Multi-domain]  Cd Length: 670  Bit Score: 657.55  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   100 AVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGE 179
Cdd:cd14930    2 SVLHNLRERYYSGLIYTYSGLFCVVINPYKQLPIYTEAIVEMYRGKKRHEVPPHVYAVTEGAYRSMLQDREDQSILCTGE 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   180 SGAGKTVNTKRVIQYFASIAAiGDRSKKEnPNAnKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKL 259
Cdd:cd14930   82 SGAGKTENTKKVIQYLAHVAS-SPKGRKE-PGV-PGELERQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVAGYI 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   260 ASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLDMLLVTNNPYdYAFVSQGEVSVASiDDSEELLATDSAFDV 339
Cdd:cd14930  159 VGANIETYLLEKSRAIRQAKDECSFHIFYQLLGGAGEQLKADLLLEPCSH-YRFLTNGPSSSPG-QERELFQETLESLRV 236
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   340 LSFTAEEKAGVYKLTGAIMHYGNMKFKQKQREEQAE-PDGTEdADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQSV 418
Cdd:cd14930  237 LGFSHEEITSMLRMVSAVLQFGNIVLKRERNTDQATmPDNTA-AQKLCRLLGLGVTDFSRALLTPRIKVGRDYVQKAQTK 315
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   419 QQVYYSIGALAKSVYEKMFNWMVTRINATLEtKQPRQ--YFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFV 496
Cdd:cd14930  316 EQADFALEALAKATYERLFRWLVLRLNRALD-RSPRQgaSFLGILDIAGFEIFQLNSFEQLCINYTNEKLQQLFNHTMFV 394
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   497 LEQEEYKKEGIEWEFIDFGMDLQACIDLIEKPM---GIMSILEEECMFPKASDMTFKAKLYDNHlGKSNNFQKPRNVkgK 573
Cdd:cd14930  395 LEQEEYQREGIPWTFLDFGLDLQPCIDLIERPAnppGLLALLDEECWFPKATDKSFVEKVAQEQ-GGHPKFQRPRHL--R 471
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   574 QEAHFSLVHYAGTVDYNIMGWLEKNKDPLNETVVGLYQKSSLKLMATLFSTYAS-------ADTGDsgKGKGGKKKGSSF 646
Cdd:cd14930  472 DQADFSVLHYAGKVDYKANEWLMKNMDPLNDNVAALLHQSTDRLTAEIWKDVEGivgleqvSSLGD--GPPGGRPRRGMF 549
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   647 QTVSALHRENLNKLMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRI 726
Cdd:cd14930  550 RTVGQLYKESLSRLMATLSNTNPSFVRCIVPNHEKRAGKLEPRLVLDQLRCNGVLEGIRICRQGFPNRILFQEFRQRYEI 629
                        650       660       670       680
                 ....*....|....*....|....*....|....*....|..
gi 6754774   727 LNPAAIPEGqFIDSRKGAEKLLGSLDIDHNQYKFGHTKVFFK 768
Cdd:cd14930  630 LTPNAIPKG-FMDGKQACEKMIQALELDPNLYRVGQSKIFFR 670
MYSc_Myo1 cd01378
class I myosin, motor domain; Myosin I generates movement at the leading edge in cell motility, ...
100-768 0e+00

class I myosin, motor domain; Myosin I generates movement at the leading edge in cell motility, and class I myosins have been implicated in phagocytosis and vesicle transport. Myosin I, an unconventional myosin, does not form dimers. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. There are 5 myosin subclasses with subclasses c/h, d/g, and a/b have an IQ domain and a TH1 domain. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276829  Cd Length: 652  Bit Score: 639.59  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   100 AVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGE 179
Cdd:cd01378    2 AINENLKKRFENDEIYTYIGHVLISVNPFKDLGIYTDEVLESYRGKNRYEVPPHVFALADSAYRNMKSEKENQCVIISGE 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   180 SGAGKTVNTKRVIQYFASIAAigdrskkeNPNANKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKL 259
Cdd:cd01378   82 SGAGKTEASKRIMQYIAAVSG--------GSESEVERVKDMLLASNPLLEAFGNAKTLRNDNSSRFGKYMEIQFDFKGEP 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   260 ASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLDMLLVTNNPYDYAFVSQGEVSVASIDDSEELLATDSAFDV 339
Cdd:cd01378  154 VGGHITNYLLEKSRVVGQIKGERNFHIFYQLLKGASQEYLQELGLQRPEQYYYYSKSGCFDVDGIDDAADFKEVLNAMKV 233
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   340 LSFTAEEKAGVYKLTGAIMHYGNMKFKQKQREEQAEPDGTEdADKSAYLMGLNSADLLKGLCHPRVKVGNEY---VTKGQ 416
Cdd:cd01378  234 IGFTEEEQDSIFRILAAILHLGNIQFAEDEEGNAAISDTSV-LDFVAYLLGVDPDQLEKALTHRTIETGGGGrsvYEVPL 312
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   417 SVQQVYYSIGALAKSVYEKMFNWMVTRINATLETKQPRQ-YFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHhmF 495
Cdd:cd01378  313 NVEQAAYARDALAKAIYSRLFDWIVERINKSLAAKSGGKkKVIGVLDIYGFEIFEKNSFEQFCINYVNEKLQQIFIE--L 390
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   496 VL--EQEEYKKEGIEWEFIDFgMDLQACIDLIE-KPMGIMSILEEECMFP-KASDMTFKAKLyDNHLGKSNNFQKPRNVK 571
Cdd:cd01378  391 TLkaEQEEYVREGIEWTPIKY-FNNKIICDLIEeKPPGIFAILDDACLTAgDATDQTFLQKL-NQLFSNHPHFECPSGHF 468
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   572 GKQEAHFSLVHYAGTVDYNIMGWLEKNKDPLNETVVGLYQKSSLKLMATLFStyASADTGDSGKGKggkkkgssfqTVSA 651
Cdd:cd01378  469 ELRRGEFRIKHYAGDVTYNVEGFLDKNKDLLFKDLKELMQSSSNPFLRSLFP--EGVDLDSKKRPP----------TAGT 536
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   652 LHRENLNKLMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAA 731
Cdd:cd01378  537 KFKNSANALVETLMKKQPSYIRCIKPNDNKSPGEFDEELVLHQVKYLGLLENVRVRRAGFAYRQTYEKFLERYKLLSPKT 616
                        650       660       670
                 ....*....|....*....|....*....|....*..
gi 6754774   732 IPEGQFIDsRKGAEKLLGSLDIDHNQYKFGHTKVFFK 768
Cdd:cd01378  617 WPAWDGTW-QGGVESILKDLNIPPEEYQMGKTKIFIR 652
MYSc_Myo7 cd01381
class VII myosin, motor domain; These monomeric myosins have been associated with functions in ...
100-768 0e+00

class VII myosin, motor domain; These monomeric myosins have been associated with functions in sensory systems such as vision and hearing. Mammalian myosin VII has a tail with 2 MyTH4 domains, 2 FERM domains, and a SH3 domain. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276832  Cd Length: 648  Bit Score: 634.29  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   100 AVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGE 179
Cdd:cd01381    2 GILRNLLIRYREKLIYTYTGSILVAVNPYQILPIYTAEQIRLYRNKKIGELPPHIFAIADNAYTNMKRNKRDQCVVISGE 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   180 SGAGKTVNTKRVIQYFASIAAigdrskkenpnaNKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKL 259
Cdd:cd01381   82 SGAGKTESTKLILQYLAAISG------------QHSWIEQQILEANPILEAFGNAKTIRNDNSSRFGKYIDIHFNKNGVI 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   260 ASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLDMLLVTnNPYDYAFVSQGE-VSVASIDDSEELLATDSAFD 338
Cdd:cd01381  150 EGAKIEQYLLEKSRIVSQAPDERNYHIFYCMLAGLSAEEKKKLELG-DASDYYYLTQGNcLTCEGRDDAAEFADIRSAMK 228
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   339 VLSFTAEEKAGVYKLTGAIMHYGNMKFKQKQRE--EQAEPDGTEDADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQ 416
Cdd:cd01381  229 VLMFTDEEIWDIFKLLAAILHLGNIKFEATVVDnlDASEVRDPPNLERAAKLLEVPKQDLVDALTTRTIFTRGETVVSPL 308
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   417 SVQQVYYSIGALAKSVYEKMFNWMVTRINATLETKQPRQYF---IGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHH 493
Cdd:cd01381  309 SAEQALDVRDAFVKGIYGRLFIWIVNKINSAIYKPRGTDSSrtsIGVLDIFGFENFEVNSFEQLCINFANENLQQFFVRH 388
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   494 MFVLEQEEYKKEGIEWEFIDFgMDLQACIDLI-EKPMGIMSILEEECMFPKASDMTFKAKLYDNHlGKSNNFQKPRNvkg 572
Cdd:cd01381  389 IFKLEQEEYDKEGINWQHIEF-VDNQDVLDLIaLKPMNIMSLIDEESKFPKGTDQTMLEKLHSTH-GNNKNYLKPKS--- 463
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   573 KQEAHFSLVHYAGTVDYNIMGWLEKNKDPLNETVVGLYQKSSLKLMATLFSTY--ASADTgdsgkgkggkkkGSSFQTVS 650
Cdd:cd01381  464 DLNTSFGINHFAGVVFYDTRGFLEKNRDTFSADLLQLVQSSKNKFLKQLFNEDisMGSET------------RKKSPTLS 531
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   651 ALHRENLNKLMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPa 730
Cdd:cd01381  532 SQFRKSLDQLMKTLSACQPFFVRCIKPNEYKKPMLFDRELCVRQLRYSGMMETIRIRKAGYPIRHTFEEFVERYRVLVP- 610
                        650       660       670
                 ....*....|....*....|....*....|....*...
gi 6754774   731 AIPEGQFIDSRKGAEKLLGSLDIDHNQYKFGHTKVFFK 768
Cdd:cd01381  611 GIPPAHKTDCRAATRKICCAVLGGDADYQLGKTKIFLK 648
MYSc_Myo8 cd01383
class VIII myosin, motor domain; These plant-specific type VIII myosins has been associated ...
99-768 0e+00

class VIII myosin, motor domain; These plant-specific type VIII myosins has been associated with endocytosis, cytokinesis, cell-to-cell coupling and gating at plasmodesmata. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. It also contains IQ domains Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276834  Cd Length: 647  Bit Score: 628.19  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    99 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRgkKRSEAPPHIFSISDNAYQYMLTDRENQSILITG 178
Cdd:cd01383    1 PSVLHNLEYRYSQDIIYTKAGPVLIAVNPFKDVPLYGNEFITAYR--QKLLDSPHVYAVADTAYREMMRDEINQSIIISG 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   179 ESGAGKTVNTKRVIQYFASIAAIGDRskkenpnankgtLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGK 258
Cdd:cd01383   79 ESGAGKTETAKIAMQYLAALGGGSSG------------IENEILQTNPILEAFGNAKTLRNDNSSRFGKLIDIHFDAAGK 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   259 LASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLDMLLVTnNPYDYAFVSQGE-VSVASIDDSEELLATDSAF 337
Cdd:cd01383  147 ICGAKIQTYLLEKSRVVQLANGERSYHIFYQLCAGASPALREKLNLK-SASEYKYLNQSNcLTIDGVDDAKKFHELKEAL 225
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   338 DVLSFTAEEKAGVYKLTGAIMHYGNMKFKQKQREEQAEPDGTEDADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQS 417
Cdd:cd01383  226 DTVGISKEDQEHIFQMLAAVLWLGNISFQVIDNENHVEVVADEAVSTAASLLGCNANDLMLALSTRKIQAGGDKIVKKLT 305
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   418 VQQVYYSIGALAKSVYEKMFNWMVTRINATLET-KQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFV 496
Cdd:cd01383  306 LQQAIDARDALAKAIYASLFDWLVEQINKSLEVgKRRTGRSISILDIYGFESFQKNSFEQLCINYANERLQQHFNRHLFK 385
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   497 LEQEEYKKEGIEWEFIDFgMDLQACIDLIE-KPMGIMSILEEECMFPKASDMTFKAKLyDNHLGKSNNFqkprnvKGKQE 575
Cdd:cd01383  386 LEQEEYELDGIDWTKVDF-EDNQECLDLIEkKPLGLISLLDEESNFPKATDLTFANKL-KQHLKSNSCF------KGERG 457
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   576 AHFSLVHYAGTVDYNIMGWLEKNKDPLNETVVGLYQKSSLKLmATLFSTYASADTGDSGKGKGGKKKGSSFQTVSALHRE 655
Cdd:cd01383  458 GAFTIRHYAGEVTYDTSGFLEKNRDLLHSDLIQLLSSCSCQL-PQLFASKMLDASRKALPLTKASGSDSQKQSVATKFKG 536
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   656 NLNKLMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEG 735
Cdd:cd01383  537 QLFKLMQRLENTTPHFIRCIKPNNKQLPGVFDQDLVLQQLRCCGVLEVVRISRSGYPTRMTHQEFARRYGFLLPEDVSAS 616
                        650       660       670
                 ....*....|....*....|....*....|...
gi 6754774   736 QFIDSRKGAekLLGSLDIDHNQYKFGHTKVFFK 768
Cdd:cd01383  617 QDPLSTSVA--ILQQFNILPEMYQVGYTKLFFR 647
MYSc_Myo22 cd14883
class XXII myosin, motor domain; These myosins possess an extended neck with multiple IQ ...
100-768 0e+00

class XXII myosin, motor domain; These myosins possess an extended neck with multiple IQ motifs such as found in class V, VIII, XI, and XIII myosins. These myosins are defined by two tandem MyTH4 and FERM domains. The apicomplexan, but not diatom myosins contain 4-6 WD40 repeats near the end of the C-terminal tail which suggests a possible function of these myosins in signal transduction and transcriptional regulation. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276849 [Multi-domain]  Cd Length: 661  Bit Score: 612.79  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   100 AVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGE 179
Cdd:cd14883    2 GINTNLKVRYKKDLIYTYTGSILVAVNPYKELPIYTQDIVKQYFGKRMGALPPHIFALAEAAYTNMQEDGKNQSVIISGE 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   180 SGAGKTVNTKRVIQYfasIAAIGDRSKKenpnankgtLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKL 259
Cdd:cd14883   82 SGAGKTETTKLILQY---LCAVTNNHSW---------VEQQILEANTILEAFGNAKTVRNDNSSRFGKFIEVCFDASGHI 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   260 ASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKK--PELLDMLLVtNNPYDYAFVSQ-GEVSVASIDDSEELLATDSA 336
Cdd:cd14883  150 KGAIIQDYLLEQSRITFQAPGERNYHVFYQLLAGAKhsKELKEKLKL-GEPEDYHYLNQsGCIRIDNINDKKDFDHLRLA 228
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   337 FDVLSFTAEEKAGVYKLTGAIMHYGNMKFKQKQREEQAE-PDGTEDADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKG 415
Cdd:cd14883  229 MNVLGIPEEMQEGIFSVLSAILHLGNLTFEDIDGETGALtVEDKEILKIVAKLLGVDPDKLKKALTIRQINVRGNVTEIP 308
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   416 QSVQQVYYSIGALAKSVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMF 495
Cdd:cd14883  309 LKVQEARDNRDAMAKALYSRTFAWLVNHINSCTNPGQKNSRFIGVLDIFGFENFKVNSFEQLCINYTNEKLHKFFNHYVF 388
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   496 VLEQEEYKKEGIEWEFIDFgMDLQACIDLIEK-PMGIMSILEEECMFPKASDMTFKAKLYDNHlGKSNNFQKPRNVKGKQ 574
Cdd:cd14883  389 KLEQEEYEKEGINWSHIVF-TDNQECLDLIEKpPLGILKLLDEECRFPKGTDLTYLEKLHAAH-EKHPYYEKPDRRRWKT 466
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   575 EahFSLVHYAGTVDYNIMGWLEKNKDPLNETVVGLYQKSSLKLMATLFS----TYASADTGDSGKGKGGKKKGSSFQTVS 650
Cdd:cd14883  467 E--FGVKHYAGEVTYTVQGFLDKNKDTQQDDLFDLMSRSKNKFVKELFTypdlLALTGLSISLGGDTTSRGTSKGKPTVG 544
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   651 ALHRENLNKLMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPA 730
Cdd:cd14883  545 DTFKHQLQSLVDVLSATQPWYVRCIKPNSLKEPNVFDDELVLAQLRYAGMLEIIRIRKEGFPIHLTFKEFVDRYLCLDPR 624
                        650       660       670
                 ....*....|....*....|....*....|....*....
gi 6754774   731 AIPEGQfiDSRKGAEK-LLGSLDIDHNQYKFGHTKVFFK 768
Cdd:cd14883  625 ARSADH--KETCGAVRaLMGLGGLPEDEWQVGKTKVFLR 661
MYSc_Myo11 cd01384
class XI myosin, motor domain; These plant-specific type XI myosin are involved in organelle ...
99-768 0e+00

class XI myosin, motor domain; These plant-specific type XI myosin are involved in organelle transport. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle.


Pssm-ID: 276835  Cd Length: 647  Bit Score: 576.94  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    99 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLP-VYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILIT 177
Cdd:cd01384    1 PGVLHNLKVRYELDEIYTYTGNILIAVNPFKRLPhLYDAHMMEQYKGAPLGELSPHVFAVADAAYRAMINEGKSQSILVS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   178 GESGAGKTVNTKRVIQYfasIAAIGDRSkkenpNANKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATG 257
Cdd:cd01384   81 GESGAGKTETTKMLMQY---LAYMGGRA-----VTEGRSVEQQVLESNPLLEAFGNAKTVRNNNSSRFGKFVEIQFDDAG 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   258 KLASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLDMLLVtNNPYDYAFVSQGE-VSVASIDDSEELLATDSA 336
Cdd:cd01384  153 RISGAAIRTYLLERSRVVQVSDPERNYHCFYQLCAGAPPEDREKYKL-KDPKQFHYLNQSKcFELDGVDDAEEYRATRRA 231
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   337 FDVLSFTAEEKAGVYKLTGAIMHYGNMKFKQKQREEQAEP--DGTEDADK-SAYLMGLNSADLLKGLCHPRVKVGNEYVT 413
Cdd:cd01384  232 MDVVGISEEEQDAIFRVVAAILHLGNIEFSKGEEDDSSVPkdEKSEFHLKaAAELLMCDEKALEDALCKRVIVTPDGIIT 311
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   414 KGQSVQQVYYSIGALAKSVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHH 493
Cdd:cd01384  312 KPLDPDAATLSRDALAKTIYSRLFDWLVDKINRSIGQDPNSKRLIGVLDIYGFESFKTNSFEQFCINLANEKLQQHFNQH 391
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   494 MFVLEQEEYKKEGIEWEFIDFgMDLQACIDLIE-KPMGIMSILEEECMFPKASDMTFKAKLYDNhLGKSNNFQKPrnvKG 572
Cdd:cd01384  392 VFKMEQEEYTKEEIDWSYIEF-VDNQDVLDLIEkKPGGIIALLDEACMFPRSTHETFAQKLYQT-LKDHKRFSKP---KL 466
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   573 KQEAhFSLVHYAGTVDYNIMGWLEKNKDPLNETVVGLYQKSSLKLMATLFSTYASADTGdsgkgkggkkKGSSFQTVSAL 652
Cdd:cd01384  467 SRTD-FTIDHYAGDVTYQTDLFLDKNKDYVVAEHQALLNASKCPFVAGLFPPLPREGTS----------SSSKFSSIGSR 535
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   653 HRENLNKLMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAI 732
Cdd:cd01384  536 FKQQLQELMETLNTTEPHYIRCIKPNNLLKPGIFENANVLQQLRCGGVLEAVRISCAGYPTRKPFEEFLDRFGLLAPEVL 615
                        650       660       670
                 ....*....|....*....|....*....|....*.
gi 6754774   733 peGQFIDSRKGAEKLLGSLDIdhNQYKFGHTKVFFK 768
Cdd:cd01384  616 --KGSDDEKAACKKILEKAGL--KGYQIGKTKVFLR 647
MYSc_Myo4 cd14872
class IV myosin, motor domain; These myosins all possess a WW domain either N-terminal or ...
99-768 8.93e-172

class IV myosin, motor domain; These myosins all possess a WW domain either N-terminal or C-terminal to their motor domain and a tail with a MyTH4 domain followed by a SH3 domain in some instances. The monomeric Acanthamoebas were the first identified members of this group and have been joined by Stramenopiles. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276839  Cd Length: 644  Bit Score: 537.82  E-value: 8.93e-172
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    99 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITG 178
Cdd:cd14872    1 AMIVHNLRKRFKNDQIYTNVGTILISVNPFKRLPLYTPTVMDQYMHKGPKEMPPHTYNIADDAYRAMIVDAMNQSILISG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   179 ESGAGKTVNTKRVIQYFASIAAigdrskkenpnaNKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGK 258
Cdd:cd14872   81 ESGAGKTEATKQCLSFFAEVAG------------STNGVEQRVLLANPILEAFGNAKTLRNNNSSRFGKWVEIHFDNRGR 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   259 LASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPElldMLLVTNNPYDYAFVSQGE-VSVASIDDSEELLATDSAF 337
Cdd:cd14872  149 ICGASTENYLLEKSRVVYQIKGERNFHIFYQLLASPDPA---SRGGWGSSAAYGYLSLSGcIEVEGVDDVADFEEVVLAM 225
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   338 DVLSFTAEEKAGVYKLTGAIMHYGNMKFKQKQREEQAEPDGTEDADKS---AYLMGLNSADLLKGLCHPRVKVgneyvtK 414
Cdd:cd14872  226 EQLGFDDADINNVMSLIAAILKLGNIEFASGGGKSLVSGSTVANRDVLkevATLLGVDAATLEEALTSRLMEI------K 299
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   415 GQ-------SVQQVYYSIGALAKSVYEKMFNWMVTRINATLE-TKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKL 486
Cdd:cd14872  300 GCdptriplTPAQATDACDALAKAAYSRLFDWLVKKINESMRpQKGAKTTFIGVLDIFGFEIFEKNSFEQLCINFTNEKL 379
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   487 QQFFNHHMFVLEQEEYKKEGIEWEFIDFgMDLQACIDLIEK-PMGIMSILEEECMFPKASDMTFKAKLYDNHLGKSnnFQ 565
Cdd:cd14872  380 QQHFNQYTFKLEEALYQSEGVKFEHIDF-IDNQPVLDLIEKkQPGLMLALDDQVKIPKGSDATFMIAANQTHAAKS--TF 456
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   566 KPRNVKGKqEAHFSLVHYAGTVDYNIMGWLEKNKDPLNETVVGLYQKSSLKLMATLFSTYasadTGDSGKGKGgkkkgss 645
Cdd:cd14872  457 VYAEVRTS-RTEFIVKHYAGDVTYDITGFLEKNKDTLQKDLYVLLSSSKNKLIAVLFPPS----EGDQKTSKV------- 524
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   646 fqTVSALHRENLNKLMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYR 725
Cdd:cd14872  525 --TLGGQFRKQLSALMTALNATEPHYIRCVKPNQEKRARLFDGFMSLEQLRYAGVFEAVKIRKTGYPFRYSHERFLKRYR 602
                        650       660       670       680
                 ....*....|....*....|....*....|....*....|...
gi 6754774   726 ILnPAAIPEGQFIDSRKGAEKLLGSLDIDHNQYKFGHTKVFFK 768
Cdd:cd14872  603 FL-VKTIAKRVGPDDRQRCDLLLKSLKQDFSKVQVGKTRVLYR 644
MYSc_Myo42 cd14903
class XLII myosin, motor domain; The class XLII myosins are comprised of Stramenopiles. Not ...
99-768 4.87e-170

class XLII myosin, motor domain; The class XLII myosins are comprised of Stramenopiles. Not much is known about this myosin class. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276868 [Multi-domain]  Cd Length: 658  Bit Score: 533.59  E-value: 4.87e-170
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    99 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLP-VYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILIT 177
Cdd:cd14903    1 AAILYNVKKRFLRKLPYTYTGDICIAVNPYQWLPeLYTEEQHSKYLNKPKEELPPHVYATSVAAYNHMKRSGRNQSILVS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   178 GESGAGKTVNTKRVIQYFASIAAigdrskkenpNANKGTLEdQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATG 257
Cdd:cd14903   81 GESGAGKTETTKILMNHLATIAG----------GLNDSTIK-KIIEVNPLLESFGNAKTVRNDNSSRFGKFTQLQFDKNG 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   258 KLASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLDMLlvtnnPYDYAFVSQGEVSVASID---DSEELLATD 334
Cdd:cd14903  150 TLVGAKCRTYLLEKTRVISHERPERNYHIFYQLLASPDVEERLFL-----DSANECAYTGANKTIKIEgmsDRKHFARTK 224
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   335 SAFDVLSFTAEEKAGVYKLTGAIMHYGNMKFKQKQREEQAE--PDGTEDADKSAYLMGLNSADLLKGLCHPRVKVGNEYV 412
Cdd:cd14903  225 EALSLIGVSEEKQEVLFEVLAGILHLGQLQIQSKPNDDEKSaiAPGDQGAVYATKLLGLSPEALEKALCSRTMRAAGDVY 304
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   413 TKGQSVQQVYYSIGALAKSVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNH 492
Cdd:cd14903  305 TVPLKKDQAEDCRDALAKAIYSNVFDWLVATINASLGNDAKMANHIGVLDIFGFEHFKHNSFEQFCINYANEKLQQKFTQ 384
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   493 HMFVLEQEEYKKEGIEWEFIDFgMDLQACIDLIEKPMGIMSILEEECMFPKASDMTFKAKLYDNHLGKSNNFQKPRNVKg 572
Cdd:cd14903  385 DVFKTVQIEYEEEGIRWAHIDF-ADNQDVLAVIEDRLGIISLLNDEVMRPKGNEESFVSKLSSIHKDEQDVIEFPRTSR- 462
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   573 kqeAHFSLVHYAGTVDYNIMGWLEKNKDPLNETVVGLYQKSSLKLMATLF----STYASADTGDSGKGKGGKKKGSSFQT 648
Cdd:cd14903  463 ---TQFTIKHYAGPVTYESLGFLEKHKDALLPDLSDLMRGSSKPFLRMLFkekvESPAAASTSLARGARRRRGGALTTTT 539
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   649 VSALHRENLNKLMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILN 728
Cdd:cd14903  540 VGTQFKDSLNELMTTIRSTNVHYVRCIKPNSIKSPTELDHLMVVSQLRCAGVIEAIRISRAAYPNRLLHEEFLDKFWLFL 619
                        650       660       670       680
                 ....*....|....*....|....*....|....*....|.
gi 6754774   729 PAAipEGQFIDSRKGAEKLLGSLDIDH-NQYKFGHTKVFFK 768
Cdd:cd14903  620 PEG--RNTDVPVAERCEALMKKLKLESpEQYQMGLTRIYFQ 658
MYSc_Myo6 cd01382
class VI myosin, motor domain; Myosin VI is a monomeric myosin, which moves towards the ...
102-768 2.00e-168

class VI myosin, motor domain; Myosin VI is a monomeric myosin, which moves towards the minus-end of actin filaments, in contrast to most other myosins which moves towards the plus-end of actin filaments. It is thought that myosin VI, unlike plus-end directed myosins, does not use a pure lever arm mechanism, but instead steps with a mechanism analogous to the kinesin neck-linker uncoupling model. It has been implicated in a myriad of functions including: the transport of cytoplasmic organelles, maintenance of normal Golgi morphology, endocytosis, secretion, cell migration, border cell migration during development, and in cancer metastasis playing roles in deafness and retinal development among others. While how this is accomplished is largely unknown there are several interacting proteins that have been identified such as disabled homolog 2 (DAB2), GIPC1, synapse-associated protein 97 (SAP97; also known as DLG1) and optineurin, which have been found to target myosin VI to different cellular compartments. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the minus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276833  Cd Length: 649  Bit Score: 529.13  E-value: 2.00e-168
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   102 LYNLKERYAAWMIYTYSGLFCVTVNPYKWLP-VYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGES 180
Cdd:cd01382    4 LNNIRVRYSKDKIYTYVANILIAVNPYFDIPkLYSSETIKSYQGKSLGTLPPHVFAIADKAYRDMKVLKQSQSIIVSGES 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   181 GAGKTVNTKRVIQYFAsiaaigdrskkENPNANKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLA 260
Cdd:cd01382   84 GAGKTESTKYILRYLT-----------ESWGSGAGPIEQRILEANPLLEAFGNAKTVRNNNSSRFGKFVEIHFNEKSSVV 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   261 SADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLDMLLvtnnpydyafvsqgevSVASIDDSEELLATDSAFDVL 340
Cdd:cd01382  153 GGFVSHYLLEKSRICVQSKEERNYHIFYRLCAGAPEDLREKLL----------------KDPLLDDVGDFIRMDKAMKKI 216
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   341 SFTAEEKAGVYKLTGAIMHYGNMKFKQKQREEQAEPDGTEDADKS----AYLMGLNSADLLKGLCHpRVKVGNEYVTKGQ 416
Cdd:cd01382  217 GLSDEEKLDIFRVVAAVLHLGNIEFEENGSDSGGGCNVKPKSEQSleyaAELLGLDQDELRVSLTT-RVMQTTRGGAKGT 295
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   417 S------VQQVYYSIGALAKSVYEKMFNWMVTRINATLETKQpRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFF 490
Cdd:cd01382  296 VikvplkVEEANNARDALAKAIYSKLFDHIVNRINQCIPFET-SSYFIGVLDIAGFEYFEVNSFEQFCINYCNEKLQQFF 374
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   491 NHHMFVLEQEEYKKEGIEWEFIDFgMDLQACIDLIE-KPMGIMSILEEECMFPKASDMTFKAKLYDNHLgksNNF--QKP 567
Cdd:cd01382  375 NERILKEEQELYEKEGLGVKEVEY-VDNQDCIDLIEaKLVGILDLLDEESKLPKPSDQHFTSAVHQKHK---NHFrlSIP 450
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   568 RnvKGKQEAH--------FSLVHYAGTVDYNIMGWLEKNKDPLNETVVGLYQKSSLKLMATLFSTYASADTGdsgkgKGG 639
Cdd:cd01382  451 R--KSKLKIHrnlrddegFLIRHFAGAVCYETAQFIEKNNDALHASLESLICESKDKFIRSLFESSTNNNKD-----SKQ 523
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   640 KKKGSSFQTVSALHRENLNKLMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGD 719
Cdd:cd01382  524 KAGKLSFISVGNKFKTQLNLLMDKLRSTGTSFIRCIKPNLKMTSHHFEGAQILSQLQCSGMVSVLDLMQGGFPSRTSFHD 603
                        650       660       670       680
                 ....*....|....*....|....*....|....*....|....*....
gi 6754774   720 FRQRYRILNPAAIPEgqfIDSRKGAEKLLGSLDIDHNQYKFGHTKVFFK 768
Cdd:cd01382  604 LYNMYKKYLPPKLAR---LDPRLFCKALFKALGLNENDFKFGLTKVFFR 649
MYSc_Myo29 cd14890
class XXIX myosin, motor domain; Class XXIX myosins are comprised of Stramenopiles and have ...
100-768 1.29e-166

class XXIX myosin, motor domain; Class XXIX myosins are comprised of Stramenopiles and have very long tail domains consisting of three IQ motifs, short coiled-coil regions, up to 18 CBS domains, a PB1 domain, and a carboxy-terminal transmembrane domain. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276855 [Multi-domain]  Cd Length: 662  Bit Score: 524.72  E-value: 1.29e-166
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   100 AVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLP-VYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYML----TDRENQSI 174
Cdd:cd14890    2 SLLHTLRLRYERDEIYTYVGPILISINPYKSIPdLYSEERMLLYHGTTAGELPPHVFAIADHAYTQLIqsgvLDPSNQSI 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   175 LITGESGAGKTVNTKRVIQYFASIAAIGDRSKKENPNANK-------GTLEDQIIQANPALEAFGNAKTVRNDNSSRFGK 247
Cdd:cd14890   82 IISGESGAGKTEATKIIMQYLARITSGFAQGASGEGEAASeaieqtlGSLEDRVLSSNPLLESFGNAKTLRNDNSSRFGK 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   248 FIRIHFGATGKLASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLDMLLVTNnPYDYAFVSQGEVSVASIDDS 327
Cdd:cd14890  162 FIEIQFDHHGKIVGAEISNFLLEKTRIVTQNDGERNYHIFYQLLAGADEALRERLKLQT-PVEYFYLRGECSSIPSCDDA 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   328 EELLATDSAFDVLSFTAEEKAGVYKLTGAIMHYGNMKFKQKQREEQAEPDGT-EDADKSAYLMGLNSADLLKGLCHPRVK 406
Cdd:cd14890  241 KAFAETIRCLSTIGISEENQDAVFGLLAAVLHLGNVDFESENDTTVLEDATTlQSLKLAAELLGVNEDALEKALLTRQLF 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   407 VGNEYVTKGQSVQQVYYSIGALAKSVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKL 486
Cdd:cd14890  321 VGGKTIVQPQNVEQARDKRDALAKALYSSLFLWLVSELNRTISSPDDKWGFIGVLDIYGFEKFEWNTFEQLCINYANEKL 400
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   487 QQFFNHHMFVLEQEEYKKEGIEWEFIDFgMDLQACIDLIE-KPMGIMSILE--EECMFPKAS--DMTFKAKLYDNHLGKS 561
Cdd:cd14890  401 QRHFNQHMFEVEQVEYSNEGIDWQYITF-NDNQACLELIEgKVNGKPGIFItlDDCWRFKGEeaNKKFVSQLHASFGRKS 479
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   562 NNFQKPRNVKGKQ---------EAHFSLVHYAGTVDYNIMGWLEKNKDPLNETVVGLYQKSSLKLMATlfstyasadtgd 632
Cdd:cd14890  480 GSGGTRRGSSQHPhfvhpkfdaDKQFGIKHYAGDVIYDASGFNEKNNETLNAEMKELIKQSRRSIREV------------ 547
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   633 sgkgkggkkkgssfqTVSALHRENLNKLMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFP 712
Cdd:cd14890  548 ---------------SVGAQFRTQLQELMAKISLTNPRYVRCIKPNETKAPGKFDGLDCLRQLKYSGMMEAIQIRQQGFA 612
                        650       660       670       680       690
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 6754774   713 NRILYGDFRQRYRILNPAAIPEGQFIdsrkgaEKLLGSLDIDHNQYKFGHTKVFFK 768
Cdd:cd14890  613 LREEHDSFFYDFQVLLPTAENIEQLV------AVLSKMLGLGKADWQIGSSKIFLK 662
MYSc_Myo3 cd01379
class III myosin, motor domain; Myosin III has been shown to play a role in the vision process ...
99-768 6.37e-166

class III myosin, motor domain; Myosin III has been shown to play a role in the vision process in insects and in hearing in mammals. Myosin III, an unconventional myosin, does not form dimers. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. They are characterized by an N-terminal protein kinase domain and several IQ domains. Some members also contain WW, SH2, PH, and Y-phosphatase domains. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276830 [Multi-domain]  Cd Length: 633  Bit Score: 521.45  E-value: 6.37e-166
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    99 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITG 178
Cdd:cd01379    1 DTIVSQLQKRYSRDQIYTYIGDILIAVNPFQNLGIYTEEHSRLYRGAKRSDNPPHIFAVADAAYQAMIHQKKNQCIVISG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   179 ESGAGKTVNTKRVIQYFASIAaigdrskkenpNANKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGK 258
Cdd:cd01379   81 ESGAGKTESANLLVQQLTVLG-----------KANNRTLEEKILQVNPLMEAFGNARTVINDNSSRFGKYLEMKFTSTGA 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   259 LASADIETYLLEKSRVIFQLKAERNYHIFYQIL----SNKKpeLLDMLLVTNNPYDYAFVSQGEVSVASIDDS--EELLA 332
Cdd:cd01379  150 VTGARISEYLLEKSRVVHQAIGERNFHIFYYIYaglaEDKK--LAKYKLPENKPPRYLQNDGLTVQDIVNNSGnrEKFEE 227
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   333 TDSAFDVLSFTAEEKAGVYKLTGAIMHYGNMKFKQKQREEQ----AEPDGTEDADKSAYLMGLNSADLLKGLCHPRVKVG 408
Cdd:cd01379  228 IEQCFKVIGFTKEEVDSVYSILAAILHIGDIEFTEVESNHQtdksSRISNPEALNNVAKLLGIEADELQEALTSHSVVTR 307
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   409 NEYVTKGQSVQQVYYSIGALAKSVYEKMFNWMVTRINATL---ETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEK 485
Cdd:cd01379  308 GETIIRNNTVEEATDARDAMAKALYGRLFSWIVNRINSLLkpdRSASDEPLSIGILDIFGFENFQKNSFEQLCINIANEQ 387
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   486 LQQFFNHHMFVLEQEEYKKEGIEWEFIDFGmDLQACID-LIEKPMGIMSILEEECMFPKASDMTFKAKLYDNHlgKSNNF 564
Cdd:cd01379  388 IQYYFNQHIFAWEQQEYLNEGIDVDLIEYE-DNRPLLDmFLQKPMGLLALLDEESRFPKATDQTLVEKFHNNI--KSKYY 464
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   565 QKPRNVkgkqEAHFSLVHYAGTVDYNIMGWLEKNKDPLNETVVGLYQKSSLKLMAtlfstyasadtgdsgkgkggkkkgs 644
Cdd:cd01379  465 WRPKSN----ALSFGIHHYAGKVLYDASGFLEKNRDTLPPDVVQLLRSSENPLVR------------------------- 515
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   645 sfQTVSALHRENLNKLMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRY 724
Cdd:cd01379  516 --QTVATYFRYSLMDLLSKMVVGQPHFVRCIKPNDSRQAGKFDREKVLKQLRYTGVLETTRIRRQGFSHRILFADFLKRY 593
                        650       660       670       680
                 ....*....|....*....|....*....|....*....|....*.
gi 6754774   725 RIL--NPAAIPEGqfidSRKGAEKLLGSLDIDHnqYKFGHTKVFFK 768
Cdd:cd01379  594 YFLafKWNEEVVA----NRENCRLILERLKLDN--WALGKTKVFLK 633
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
848-1925 1.57e-165

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 535.91  E-value: 1.57e-165
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     848 EKEMANMKEEFGRVKDALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKIQLEAKVKEMTER 927
Cdd:pfam01576    4 EEEMQAKEEELQKVKERQQKAESELKELEKKHQQLCEEKNALQEQLQAETELCAEAEEMRARLAARKQELEEILHELESR 83
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     928 LEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQ 1007
Cdd:pfam01576   84 LEEEEERSQQLQNEKKKMQQHIQDLEEQLDEEEAARQKLQLEKVTTEAKIKKLEEDILLLEDQNSKLSKERKLLEERISE 163
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1008 ALDDLQAEEDKVNTLTKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEF 1087
Cdd:pfam01576  164 FTSNLAEEEEKAKSLSKLKNKHEAMISDLEERLKKEEKGRQELEKAKRKLEGESTDLQEQIAELQAQIAELRAQLAKKEE 243
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1088 DISQQNSKIEDEQALALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNK 1167
Cdd:pfam01576  244 ELQAALARLEEETAQKNNALKKIRELEAQISELQEDLESERAARNKAEKQRRDLGEELEALKTELEDTLDTTAAQQELRS 323
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1168 KREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANL 1247
Cdd:pfam01576  324 KREQEVTELKKALEEETRSHEAQLQEMRQKHTQALEELTEQLEQAKRNKANLEKAKQALESENAELQAELRTLQQAKQDS 403
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1248 EKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKA 1327
Cdd:pfam01576  404 EHKRKKLEGQLQELQARLSESERQRAELAEKLSKLQSELESVSSLLNEAEGKNIKLSKDVSSLESQLQDTQELLQEETRQ 483
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1328 KNALAHALQSSRHDCDLLREQYEEEMEAKAELQRVLSKANSEVAQWRTKYETDAiQRTEELEEAKKKLAQRLQDAEEAVE 1407
Cdd:pfam01576  484 KLNLSTRLRQLEDERNSLQEQLEEEEEAKRNVERQLSTLQAQLSDMKKKLEEDA-GTLEALEEGKKRLQRELEALTQQLE 562
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1408 AVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLK 1487
Cdd:pfam01576  563 EKAAAYDKLEKTKNRLQQELDDLLVDLDHQRQLVSNLEKKQKKFDQMLAEEKAISARYAEERDRAEAEAREKETRALSLA 642
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1488 NAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKIRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEF 1567
Cdd:pfam01576  643 RALEEALEAKEELERTNKQLRAEMEDLVSSKDDVGKNVHELERSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNM 722
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1568 NQIKAEIERKLAEKDEEMEQAKRNHLRMVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSQANRIASEAQKHLKN 1647
Cdd:pfam01576  723 QALKAQFERDLQARDEQGEEKRRQLVKQVRELEAELEDERKQRAQAVAAKKKLELDLKELEAQIDAANKGREEAVKQLKK 802
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1648 SQAHLKDTQLQLDDAVHANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLIN 1727
Cdd:pfam01576  803 LQAQMKDLQRELEEARASRDEILAQSKESEKKLKNLEAELLQLQEDLAASERARRQAQQERDELADEIASGASGKSALQD 882
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1728 QKKKMESDLTQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIAL 1807
Cdd:pfam01576  883 EKRRLEARIAQLEEELEEEQSNTELLNDRLRKSTLQVEQLTTELAAERSTSQKSESARQQLERQNKELKAKLQEMEGTVK 962
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1808 KGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLMRLQDLVDKLQLKVKAYKRQAEEA 1887
Cdd:pfam01576  963 SKFKSSIAALEAKIAQLEEQLEQESRERQAANKLVRRTEKKLKEVLLQVEDERRHADQYKDQAEKGNSRMKQLKRQLEEA 1042
                         1050      1060      1070
                   ....*....|....*....|....*....|....*...
gi 6754774    1888 EEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAK 1925
Cdd:pfam01576 1043 EEEASRANAARRKLQRELDDATESNESMNREVSTLKSK 1080
MYSc_Myo27 cd14888
class XXVII myosin, motor domain; Not much is known about this myosin class. The catalytic ...
99-768 1.75e-164

class XXVII myosin, motor domain; Not much is known about this myosin class. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276853 [Multi-domain]  Cd Length: 667  Bit Score: 518.86  E-value: 1.75e-164
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    99 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLP-VYNAEVVAAYRgKKRSEAPPHIFSISDNAYQYMLTDRENQSILIT 177
Cdd:cd14888    1 ASILHSLNLRFDIDEIYTFTGPILIAVNPFKTIPgLYSDEMLLKFI-QPSISKSPHVFSTASSAYQGMCNNKKSQTILIS 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   178 GESGAGKTVNTKRVIQYFASIaaiGDRSKKenpnaNKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHF---- 253
Cdd:cd14888   80 GESGAGKTESTKYVMKFLACA---GSEDIK-----KRSLVEAQVLESNPLLEAFGNARTLRNDNSSRFGKFIELQFsklk 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   254 -----GATGKLASADIETYLLEKSRVIFQLKAERNYHIFYQILS-----------------------NKKPELLDMLL-V 304
Cdd:cd14888  152 skrmsGDRGRLCGAKIQTYLLEKVRVCDQQEGERNYHIFYQLCAaareakntglsyeendeklakgaDAKPISIDMSSfE 231
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   305 TNNPYDYAFVSqGEVSVASIDDSEELLATDSAFDVLSFTAEEKAGVYKLTGAIMHYGNMKFKQKQREEQA---EPDGTED 381
Cdd:cd14888  232 PHLKFRYLTKS-SCHELPDVDDLEEFESTLYAMQTVGISPEEQNQIFSIVAAILYLGNILFENNEACSEGavvSASCTDD 310
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   382 ADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQSVQQVYYSIGALAKSVYEKMFNWMVTRINATLE-TKQPRQYFIGV 460
Cdd:cd14888  311 LEKVASLLGVDAEDLLNALCYRTIKTAHEFYTKPLRVDEAEDVRDALARALYSCLFDKVVERTNESIGySKDNSLLFCGV 390
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   461 LDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGmDLQACIDLI-EKPMGIMSILEEEC 539
Cdd:cd14888  391 LDIFGFECFQLNSFEQLCINFTNERLQQFFNNFVFKCEEKLYIEEGISWNPLDFP-DNQDCVDLLqEKPLGIFCMLDEEC 469
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   540 MFPKASDMTFKAKLYDNHLGkSNNFQKprnVKGKQEAhFSLVHYAGTVDYNIMGWLEKNKDPLNETVVGLYQKSSLKLMA 619
Cdd:cd14888  470 FVPGGKDQGLCNKLCQKHKG-HKRFDV---VKTDPNS-FVIVHFAGPVKYCSDGFLEKNKDQLSVDAQEVIKNSKNPFIS 544
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   620 TLFSTYASADTGdsgkgkgGKKKGSSFQTVSALHRENLNKLMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNG 699
Cdd:cd14888  545 NLFSAYLRRGTD-------GNTKKKKFVTVSSEFRNQLDVLMETIDKTEPHFIRCIKPNSQNVPDLFDRISVNEQLKYGG 617
                        650       660       670       680       690       700
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6754774   700 VLEGIRICRKGFPNRILYGDFRQRYRILNPaaipegqfidsrkgaekllGSLDIDHNQYKFGHTKVFFK 768
Cdd:cd14888  618 VLQAVQVSRAGYPVRLSHAEFYNDYRILLN-------------------GEGKKQLSIWAVGKTLCFFK 667
MYSc_Myo15 cd01387
class XV mammal-like myosin, motor domain; The class XV myosins are monomeric. In vertebrates, ...
100-768 1.74e-163

class XV mammal-like myosin, motor domain; The class XV myosins are monomeric. In vertebrates, myosin XV appears to be expressed in sensory tissue and play a role in hearing. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. C-terminal to the head domain are 2 MyTH4 domain, a FERM domain, and a SH3 domain. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276838 [Multi-domain]  Cd Length: 657  Bit Score: 515.84  E-value: 1.74e-163
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   100 AVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGE 179
Cdd:cd01387    2 TVLWNLKTRYERNLIYTYIGSILVSVNPYKMFDIYGLEQVQQYSGRALGELPPHLFAIANLAFAKMLDAKQNQCVVISGE 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   180 SGAGKTVNTKRVIQYFASIaaigdrskkeNPNANKGTLEdQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFgATGKL 259
Cdd:cd01387   82 SGSGKTEATKLIMQYLAAV----------NQRRNNLVTE-QILEATPLLEAFGNAKTVRNDNSSRFGKYLEVFF-EGGVI 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   260 ASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKkPELLDMLLVTNNPYDYAFVSQG-EVSVASIDDSEELLATDSAFD 338
Cdd:cd01387  150 VGAITSQYLLEKSRIVTQAKNERNYHVFYELLAGL-PAQLRQKYGLQEAEKYFYLNQGgNCEIAGKSDADDFRRLLAAMQ 228
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   339 VLSFTAEEKAGVYKLTGAIMHYGNMKFKQKQRE---EQAEPDGTEDADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKG 415
Cdd:cd01387  229 VLGFSSEEQDSIFRILASVLHLGNVYFHKRQLRhgqEGVSVGSDAEIQWVAHLLQISPEGLQKALTFKVTETRRERIFTP 308
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   416 QSVQQVYYSIGALAKSVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMF 495
Cdd:cd01387  309 LTIDQALDARDAIAKALYALLFSWLVTRVNAIVYSGTQDTLSIAILDIFGFEDLSENSFEQLCINYANENLQYYFNKHVF 388
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   496 VLEQEEYKKEGIEWEFIDFgMDLQACIDLI-EKPMGIMSILEEECMFPKASDMTFKAKLYDNHlGKSNNFQKPRnvKGKQ 574
Cdd:cd01387  389 KLEQEEYIREQIDWTEIAF-ADNQPVINLIsKKPVGILHILDDECNFPQATDHSFLEKCHYHH-ALNELYSKPR--MPLP 464
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   575 EahFSLVHYAGTVDYNIMGWLEKNKDPLNETVVGLYQKSSLKLMATLFSTYAS--ADTGDSGKGKGGKKKGSSFQTVSAL 652
Cdd:cd01387  465 E--FTIKHYAGQVWYQVHGFLDKNRDQLRQDVLELLVSSRTRVVAHLFSSHRAqtDKAPPRLGKGRFVTMKPRTPTVAAR 542
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   653 HRENLNKLMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAI 732
Cdd:cd01387  543 FQDSLLQLLEKMERCNPWFVRCLKPNHKKEPMLFDMDVVMAQLRYSGMLETIRIRKEGYPVRLPFQVFIDRYRCLVALKL 622
                        650       660       670
                 ....*....|....*....|....*....|....*...
gi 6754774   733 PEGQFIDSRkgaEKLLGSLD--IDHNQYKFGHTKVFFK 768
Cdd:cd01387  623 PRPAPGDMC---VSLLSRLCtvTPKDMYRLGATKVFLR 657
MYSc_Myo40 cd14901
class XL myosin, motor domain; The class XL myosins are comprised of Stramenopiles. Not much ...
99-766 1.92e-161

class XL myosin, motor domain; The class XL myosins are comprised of Stramenopiles. Not much is known about this myosin class. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276866 [Multi-domain]  Cd Length: 655  Bit Score: 510.10  E-value: 1.92e-161
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    99 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAY------RGKKRSEAPPHIFSISDNAYQYMLTDRE-- 170
Cdd:cd14901    1 PSILHVLRRRFAHGLIYTSTGAILVAINPFRRLPLYDDETKEAYyehgerRAAGERKLPPHVYAVADKAFRAMLFASRgq 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   171 --NQSILITGESGAGKTVNTKRVIQYFASIAAigdRSKKENPNANKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKF 248
Cdd:cd14901   81 kcDQSILVSGESGAGKTETTKIIMNYLASVSS---ATTHGQNATERENVRDRVLESNPILEAFGNARTNRNNNSSRFGKF 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   249 IRIHFGATGKLASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLDMLLVTNNP-YDYAFVSQGEVSVASIDDS 327
Cdd:cd14901  158 IRLGFASSGSLLGASISTYLLERVRLVSQAKGERNYHIFYELLRGASSDELHALGLTHVEeYKYLNSSQCYDRRDGVDDS 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   328 EELLATDSAFDVLSFTAEEKAGVYKLTGAIMHYGNMKFKQKQREEQAEPDGTE-DADKSAYLMGLNSADLLKGLCHPRVK 406
Cdd:cd14901  238 VQYAKTRHAMTTIGMSPDEQISVLQLVAAVLHLGNLCFVKKDGEGGTFSMSSLaNVRAACDLLGLDMDVLEKTLCTREIR 317
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   407 VGNEYVTKGQSVQQVYYSIGALAKSVYEKMFNWMVTRINATLETKQP--RQYFIGVLDIAGFEIFDFNSFEQLCINFTNE 484
Cdd:cd14901  318 AGGEYITMPLSVEQALLTRDVVAKTLYAQLFDWLVDRINESIAYSEStgASRFIGIVDIFGFEIFATNSLEQLCINFANE 397
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   485 KLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDlQACIDLIE-KPMGIMSILEEECMFPKASDMTFKAKLYDNhLGKSNN 563
Cdd:cd14901  398 KLQQLFGKFVFEMEQDEYVAEAIPWTFVEYPNN-DACVAMFEaRPTGLFSLLDEQCLLPRGNDEKLANKYYDL-LAKHAS 475
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   564 FQKPRNVKGKQEahFSLVHYAGTVDYNIMGWLEKNKDPLNETVVGLYQKSSLKLMATlfstyasadtgdsgkgkggkkkg 643
Cdd:cd14901  476 FSVSKLQQGKRQ--FVIHHYAGAVCYATDGFCDKNKDHVHSEALALLRTSSNAFLSS----------------------- 530
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   644 ssfqTVSALHRENLNKLMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQR 723
Cdd:cd14901  531 ----TVVAKFKVQLSSLLEVLNATEPHFIRCIKPNDVLSPSEFDAKRVLEQLRCSGVLEAVKISRSGYPVRFPHDAFVHT 606
                        650       660       670       680
                 ....*....|....*....|....*....|....*....|....*..
gi 6754774   724 YRILNPAAIPEGQFIDSRKGAEKLLGSLDI----DHNQYKFGHTKVF 766
Cdd:cd14901  607 YSCLAPDGASDTWKVNELAERLMSQLQHSElnieHLPPFQVGKTKVF 653
MYSc_Myo31 cd14892
class XXXI myosin, motor domain; Class XXXI myosins have a very long neck region consisting of ...
105-768 1.36e-157

class XXXI myosin, motor domain; Class XXXI myosins have a very long neck region consisting of 17 IQ motifs and 2 tandem ANK repeats that are separated by a PH domain. The myosin classes XXX to XXXIV contain members from Phytophthora species and Hyaloperonospora parasitica. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276857 [Multi-domain]  Cd Length: 656  Bit Score: 499.67  E-value: 1.36e-157
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   105 LKERYAAWMIYTYSGLFCVTVNPYKWLP-VYNAEVVAAYRG--KKRSEAPPHIFSISDNAYQYMLTDR----ENQSILIT 177
Cdd:cd14892    7 LRRRYERDAIYTFTADILISINPYKSIPlLYDVPGFDSQRKeeATASSPPPHVFSIAERAYRAMKGVGkgqgTPQSIVVS 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   178 GESGAGKTVNTKRVIQYFASIAAIGDRSKKENPNANKGT-LEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGAT 256
Cdd:cd14892   87 GESGAGKTEASKYIMKYLATASKLAKGASTSKGAANAHEsIEECVLLSNLILEAFGNAKTIRNDNSSRFGKYIQIHYNSD 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   257 GKLASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKpELLDMLLVTNNPYDYAFVSQGE-VSVASIDDSEELLATDS 335
Cdd:cd14892  167 GRIAGASTDHFLLEKSRLVGPDANERNYHIFYQLLAGLD-ANENAALELTPAESFLFLNQGNcVEVDGVDDATEFKQLRD 245
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   336 AFDVLSFTAEEKAGVYKLTGAIMHYGNMKFKQ--KQREEQAEPDGTEDADKSAYLMGLNSADLLKGLC-----HPRVKVG 408
Cdd:cd14892  246 AMEQLGFDAEFQRPIFEVLAAVLHLGNVRFEEnaDDEDVFAQSADGVNVAKAAGLLGVDAAELMFKLVtqttsTARGSVL 325
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   409 NEYVTKGQSVQqvyySIGALAKSVYEKMFNWMVTRINAtlETKQ------------PRQYFIGVLDIAGFEIFDFNSFEQ 476
Cdd:cd14892  326 EIKLTAREAKN----ALDALCKYLYGELFDWLISRINA--CHKQqtsgvtggaaspTFSPFIGILDIFGFEIMPTNSFEQ 399
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   477 LCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFgMDLQACIDLIEK-PMGIMSILEEECMFP-KASDMTFKAKLY 554
Cdd:cd14892  400 LCINFTNEMLQQQFNKHVFVLEQEVYASEGIDVSAIEF-QDNQDCLDLIQKkPLGLLPLLEEQMLLKrKTTDKQLLTIYH 478
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   555 DNHLGKSNNFQKPRNvkgkQEAHFSLVHYAGTVDYNIMGWLEKNKDPLNETVVGLYQKSSlklmatlfstyasadtgdsg 634
Cdd:cd14892  479 QTHLDKHPHYAKPRF----ECDEFVLRHYAGDVTYDVHGFLAKNNDNLHDDLRDLLRSSS-------------------- 534
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   635 kgkggkkkgsSFqtvsalhRENLNKLMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNR 714
Cdd:cd14892  535 ----------KF-------RTQLAELMEVLWSTTPSYIKCIKPNNLKFPGGFSCELVRDQLIYSGVLEVVRIRREGFPIR 597
                        650       660       670       680       690
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 6754774   715 ILYGDFRQRYRIL-----NPAAIPEGQFIDSRKGAEKLLGSLDIDHNQYKFGHTKVFFK 768
Cdd:cd14892  598 RQFEEFYEKFWPLarnkaGVAASPDACDATTARKKCEEIVARALERENFQLGRTKVFLR 656
MYSc_Myo9 cd01385
class IX myosin, motor domain; Myosin IX is a processive single-headed motor, which might play ...
102-768 7.82e-157

class IX myosin, motor domain; Myosin IX is a processive single-headed motor, which might play a role in signalling. It has a N-terminal RA domain, an IQ domain, a C1_1 domain, and a RhoGAP domain. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276836 [Multi-domain]  Cd Length: 690  Bit Score: 498.82  E-value: 7.82e-157
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   102 LYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGESG 181
Cdd:cd01385    4 LENLRARFKHGKIYTYVGSILIAVNPFKFLPIYNPKYVKMYQNRRLGKLPPHIFAIADVAYHAMLRKKKNQCIVISGESG 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   182 AGKTVNTKRVIQYFASIAAIGDRSKKENpnankgtledQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLAS 261
Cdd:cd01385   84 SGKTESTNFLLHHLTALSQKGYGSGVEQ----------TILGAGPVLEAFGNAKTAHNNNSSRFGKFIQVNYRENGMVRG 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   262 ADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLDMLLVTnNPYDYAFVSQGE-VSVASIDDSEELLATDSAFDVL 340
Cdd:cd01385  154 AVVEKYLLEKSRIVSQEKNERNYHVFYYLLAGASEEERKELHLK-QPEDYHYLNQSDcYTLEGEDEKYEFERLKQAMEMV 232
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   341 SFTAEEKAGVYKLTGAIMHYGNMKFKQK--QREEQAEPDGTEDADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQSV 418
Cdd:cd01385  233 GFLPETQRQIFSVLSAVLHLGNIEYKKKayHRDESVTVGNPEVLDIISELLRVKEETLLEALTTKKTVTVGETLILPYKL 312
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   419 QQVYYSIGALAKSVYEKMFNWMVTRINATLETKQ----PRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHM 494
Cdd:cd01385  313 PEAIATRDAMAKCLYSALFDWIVLRINHALLNKKdleeAKGLSIGVLDIFGFEDFGNNSFEQFCINYANEHLQYYFNQHI 392
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   495 FVLEQEEYKKEGIEWEFIDFgMDLQACIDLIE-KPMGIMSILEEECMFPKASDMTFKAKlYDNHLGKSNNFQKPRnvkgK 573
Cdd:cd01385  393 FKLEQEEYKKEGISWHNIEY-TDNTGCLQLISkKPTGLLCLLDEESNFPGATNQTLLAK-FKQQHKDNKYYEKPQ----V 466
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   574 QEAHFSLVHYAGTVDYNIMGWLEKNKDPLNETVVGLYQKSSLKLM------------------ATLFSTYASADTGDSGK 635
Cdd:cd01385  467 MEPAFIIAHYAGKVKYQIKDFREKNLDLMRPDIVAVLRSSSSAFVreligidpvavfrwavlrAFFRAMAAFREAGRRRA 546
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   636 GKGGKKKGSSFQ----------------TVSALHRENLNKLMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNG 699
Cdd:cd01385  547 QRTAGHSLTLHDrttksllhlhkkkkppSVSAQFQTSLSKLMETLGQAEPFFIRCIKSNAEKKPLRFDDELVLRQLRYTG 626
                        650       660       670       680       690       700
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6754774   700 VLEGIRICRKGFPNRILYGDFRQRYRILnpaaIPEGQfIDSRKGAEKLLGSLDIDHNQYKFGHTKVFFK 768
Cdd:cd01385  627 MLETVRIRRSGYSVRYTFQEFITQFQVL----LPKGL-ISSKEDIKDFLEKLNLDRDNYQIGKTKVFLK 690
MYSc_Myo10 cd14873
class X myosin, motor domain; Myosin X is an unconventional myosin motor that functions as a ...
100-768 2.09e-154

class X myosin, motor domain; Myosin X is an unconventional myosin motor that functions as a monomer. In mammalian cells, the motor is found to localize to filopodia. Myosin X walks towards the barbed ends of filaments and is thought to walk on bundles of actin, rather than single filaments, a unique behavior. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. C-terminal to the head domain are a variable number of IQ domains, 2 PH domains, a MyTH4 domain, and a FERM domain. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276840 [Multi-domain]  Cd Length: 651  Bit Score: 490.85  E-value: 2.09e-154
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   100 AVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLP-VYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITG 178
Cdd:cd14873    2 SIMYNLFQRYKRNQIYTYIGSILASVNPYQPIAgLYEPATMEQYSRRHLGELPPHIFAIANECYRCLWKRHDNQCILISG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   179 ESGAGKTVNTKRVIQYFASIAAIGDRSKKENPNANkgtLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGK 258
Cdd:cd14873   82 ESGAGKTESTKLILKFLSVISQQSLELSLKEKTSC---VEQAILESSPIMEAFGNAKTVYNNNSSRFGKFVQLNICQKGN 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   259 LASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLDMLLVTnNPYDYAFVSQ-GEVSVASIDDSEELLATDSAF 337
Cdd:cd14873  159 IQGGRIVDYLLEKNRVVRQNPGERNYHIFYALLAGLEHEEREEFYLS-TPENYHYLNQsGCVEDKTISDQESFREVITAM 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   338 DVLSFTAEEKAGVYKLTGAIMHYGNMKFKQKQREEQAEPDGTEDadkSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQS 417
Cdd:cd14873  238 EVMQFSKEEVREVSRLLAGILHLGNIEFITAGGAQVSFKTALGR---SAELLGLDPTQLTDALTQRSMFLRGEEILTPLN 314
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   418 VQQVYYSIGALAKSVYEKMFNWMVTRINATLETKQPRQyFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVL 497
Cdd:cd14873  315 VQQAVDSRDSLAMALYARCFEWVIKKINSRIKGKEDFK-SIGILDIFGFENFEVNHFEQFNINYANEKLQEYFNKHIFSL 393
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   498 EQEEYKKEGIEWEFIDFgMDLQACIDLIEKPMGIMSILEEECMFPKASDMTFKAKLYDNHlgkSNN--FQKPRnvkgKQE 575
Cdd:cd14873  394 EQLEYSREGLVWEDIDW-IDNGECLDLIEKKLGLLALINEESHFPQATDSTLLEKLHSQH---ANNhfYVKPR----VAV 465
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   576 AHFSLVHYAGTVDYNIMGWLEKNKDPLNETVVGLYQKSSLKLMATLFSTYASADTGDSGKGKGGKKKgssfQTVSALHRE 655
Cdd:cd14873  466 NNFGVKHYAGEVQYDVRGILEKNRDTFRDDLLNLLRESRFDFIYDLFEHVSSRNNQDTLKCGSKHRR----PTVSSQFKD 541
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   656 NLNKLMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNP-AAIPE 734
Cdd:cd14873  542 SLHSLMATLSSSNPFFVRCIKPNMQKMPDQFDQAVVLNQLRYSGMLETVRIRKAGYAVRRPFQDFYKRYKVLMRnLALPE 621
                        650       660       670
                 ....*....|....*....|....*....|....
gi 6754774   735 gqfiDSRKGAEKLLGSLDIDHNQYKFGHTKVFFK 768
Cdd:cd14873  622 ----DVRGKCTSLLQLYDASNSEWQLGKTKVFLR 651
MYSc_Myo36 cd14897
class XXXVI myosin, motor domain; This class of molluscan myosins contains a motor domain ...
101-768 3.04e-148

class XXXVI myosin, motor domain; This class of molluscan myosins contains a motor domain followed by a GlcAT-I (Beta1,3-glucuronyltransferase I) domain. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276862 [Multi-domain]  Cd Length: 635  Bit Score: 473.41  E-value: 3.04e-148
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   101 VLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKK-RSEAPPHIFSISDNAYQYMLTDRENQSILITGE 179
Cdd:cd14897    3 IVQTLKSRYNKDKFYTYIGDILVAVNPCKPLPIFDKKHHEEYSNLSvRSQRPPHLFWIADQAYRRLLETGRNQCILVSGE 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   180 SGAGKTVNTKRVIQYFASIaaigdrSKKENPNankgtLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKL 259
Cdd:cd14897   83 SGAGKTESTKYMIKHLMKL------SPSDDSD-----LLDKIVQINPLLEAFGNASTVMNDNSSRFGKFIELHFTENGQL 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   260 ASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLDMLLVtNNPYDYAFVSQGEVSVASIDDSEELLATDSAFDV 339
Cdd:cd14897  152 LGAKIDDYLLEKSRVVHRGNGEKNFHIFYALFAGMSRDRLLYYFL-EDPDCHRILRDDNRNRPVFNDSEELEYYRQMFHD 230
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   340 L-------SFTAEEKAGVYKLTGAIMHYGNMKFkqkqrEEQAEPDGTEDADK-----SAYLMGLNSADLLKGLCHPRVKV 407
Cdd:cd14897  231 LtnimkliGFSEEDISVIFTILAAILHLTNIVF-----IPDEDTDGVTVADEyplhaVAKLLGIDEVELTEALISNVNTI 305
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   408 GNEYVTKGQSVQQVYYSIGALAKSVYEKMFNWMVTRINATLETKQPRQYF-----IGVLDIAGFEIFDFNSFEQLCINFT 482
Cdd:cd14897  306 RGERIQSWKSLRQANDSRDALAKDLYSRLFGWIVGQINRNLWPDKDFQIMtrgpsIGILDMSGFENFKINSFDQLCINLS 385
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   483 NEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFgMDLQACIDLI-EKPMGIMSILEEECMFPKASDMTFKAKLyDNHLGKS 561
Cdd:cd14897  386 NERLQQYFNDYVFPRERSEYEIEGIEWRDIEY-HDNDDVLELFfKKPLGILPLLDEESTFPQSTDSSLVQKL-NKYCGES 463
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   562 NNFQKPrnvKGKQEAhFSLVHYAGTVDYNIMGWLEKNKDPLNETVVGLYQKSSLKLMATLFSTYasadtgdsgkgkggkk 641
Cdd:cd14897  464 PRYVAS---PGNRVA-FGIRHYAEQVTYDADGFLEKNRDNLSSDIVGCLLNSNNEFISDLFTSY---------------- 523
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   642 kgssfqtvsalHRENLNKLMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFR 721
Cdd:cd14897  524 -----------FKRSLSDLMTKLNSADPLFVRCIKPNNFLRPNKFDDELVRRQLLCNGLMEIAKIRRDGYPIRIKYEDFV 592
                        650       660       670       680
                 ....*....|....*....|....*....|....*....|....*....
gi 6754774   722 QRYRILNPAAIPegqfidSRKGAE-KLLGSLDIDHNQ-YKFGHTKVFFK 768
Cdd:cd14897  593 KRYKEICDFSNK------VRSDDLgKCQKILKTAGIKgYQFGKTKVFLK 635
MYSc_Myo39 cd14900
class XXXIX myosin, motor domain; The class XXXIX myosins are found in Stramenopiles. Not much ...
101-733 3.23e-143

class XXXIX myosin, motor domain; The class XXXIX myosins are found in Stramenopiles. Not much is known about this myosin class. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276865  Cd Length: 627  Bit Score: 459.00  E-value: 3.23e-143
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   101 VLYNLKERYAAWMIYTYSGLFCVTVNPYKWLP-VYNAEVVAAY-----------RGKKRSEAPPHIFSISDNAYQYM--- 165
Cdd:cd14900    3 ILSALETRFYAQKIYTNTGAILLAVNPFQKLPgLYSSDTMAKYllsfearssstRNKGSDPMPPHIYQVAGEAYKAMmlg 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   166 -LTDRENQSILITGESGAGKTVNTKRVIQYFASIAAIGDRSKKENPnANKGTLEDQIIQANPALEAFGNAKTVRNDNSSR 244
Cdd:cd14900   83 lNGVMSDQSILVSGESGSGKTESTKFLMEYLAQAGDNNLAASVSMG-KSTSGIAAKVLQTNILLESFGNARTLRNDNSSR 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   245 FGKFIRIHFGATGKLASADIETYLLEKSRVIFQLKAERNYHIFYQILsnkkpelldmllvtnnpydyafVSQGEVSVASi 324
Cdd:cd14900  162 FGKFIKLHFTSGGRLTGASIQTYLLEKVRLVSQSKGERNYHIFYEMA----------------------IGASEAARKR- 218
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   325 DDSEELLAtdsAFDVLSFTAEEKAGVYKLTGAIMHYGNMKFKQKQREEQAEPDGTEDA-------DKSAYLMGLNSADLL 397
Cdd:cd14900  219 DMYRRVMD---AMDIIGFTPHERAGIFDLLAALLHIGNLTFEHDENSDRLGQLKSDLApssiwsrDAAATLLSVDATKLE 295
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   398 KGLCHPRVKVGNEYVTKGQSVQQVYYSIGALAKSVYEKMFNWMVTRINATL-----ETKQPRQYFIGVLDIAGFEIFDFN 472
Cdd:cd14900  296 KALSVRRIRAGTDFVSMKLSAAQANNARDALAKALYGRLFDWLVGKMNAFLkmddsSKSHGGLHFIGILDIFGFEVFPKN 375
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   473 SFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFgMDLQACIDLI-EKPMGIMSILEEECMFPKASDMTFKA 551
Cdd:cd14900  376 SFEQLCINFANETLQQQFNDYVFKAEQREYESQGVDWKYVEF-CDNQDCVNLIsQRPTGILSLIDEECVMPKGSDTTLAS 454
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   552 KLYdNHLGKSNNFQKPRNVKGKqeAHFSLVHYAGTVDYNIMGWLEKNKDPLNETVVGLYQKsslklmatlfstyasadtg 631
Cdd:cd14900  455 KLY-RACGSHPRFSASRIQRAR--GLFTIVHYAGHVEYSTDGFLEKNKDVLHQEAVDLFVY------------------- 512
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   632 dsgkgkggkkkgssfqtvSALHRENLNKLMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGF 711
Cdd:cd14900  513 ------------------GLQFKEQLTTLLETLQQTNPHYVRCLKPNDLCKAGIYERERVLNQLRCNGVMEAVRVARAGF 574
                        650       660
                 ....*....|....*....|..
gi 6754774   712 PNRILYGDFRQRYRILNPAAIP 733
Cdd:cd14900  575 PIRLLHDEFVARYFSLARAKNR 596
MYSc_Myo43 cd14904
class XLIII myosin, motor domain; The class XLIII myosins are comprised of Stramenopiles. Not ...
99-768 5.07e-143

class XLIII myosin, motor domain; The class XLIII myosins are comprised of Stramenopiles. Not much is known about this myosin class. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276869  Cd Length: 653  Bit Score: 459.41  E-value: 5.07e-143
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    99 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLP-VYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILIT 177
Cdd:cd14904    1 PSILFNLKKRFAASKPYTYTNDIVIALNPYKWIDnLYGDHLHEQYLKKPRDKLQPHVYATSTAAYKHMLTNEMNQSILVS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   178 GESGAGKTVNTKRVIQYFASIAaiGDRSKKenpnankgTLeDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATG 257
Cdd:cd14904   81 GESGAGKTETTKIVMNHLASVA--GGRKDK--------TI-AKVIDVNPLLESFGNAKTTRNDNSSRFGKFTQLQFDGRG 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   258 KLASADIETYLLEKSRVIFQLKAERNYHIFYQILSN-KKPELLDMLLVTNNPYDYAFVSQGEVSVASIDDSEELLATDSA 336
Cdd:cd14904  150 KLIGAKCETYLLEKSRVVSIAEGERNYHIFYQLLAGlSSEERKEFGLDPNCQYQYLGDSLAQMQIPGLDDAKLFASTQKS 229
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   337 FDVLSFTAEEKAGVYKLTGAIMHYGNMKFkQKQREEQAEPDGTEDADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQ 416
Cdd:cd14904  230 LSLIGLDNDAQRTLFKILSGVLHLGEVMF-DKSDENGSRISNGSQLSQVAKMLGLPTTRIEEALCNRSVVTRNESVTVPL 308
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   417 SVQQVYYSIGALAKSVYEKMFNWMVTRINATLETKQPRQY-FIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMF 495
Cdd:cd14904  309 APVEAEENRDALAKAIYSKLFDWMVVKINAAISTDDDRIKgQIGVLDIFGFEDFAHNGFEQFCINYANEKLQQKFTTDVF 388
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   496 VLEQEEYKKEGIEWEFIDFgMDLQACIDLIEKPMGIMSILEEECMFPKASDMTFKAKLYDNH--LGKSNNFQKPRnVKGK 573
Cdd:cd14904  389 KTVEEEYIREGLQWDHIEY-QDNQGIVEVIDGKMGIIALMNDHLRQPRGTEEALVNKIRTNHqtKKDNESIDFPK-VKRT 466
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   574 QeahFSLVHYAGTVDYNIMGWLEKNKDPLNETVVGLYQKSSLKLMATLFStyaSADTGDSGKGKGGKKKGSSFQTVSALH 653
Cdd:cd14904  467 Q---FIINHYAGPVTYETVGFMEKHRDTLQNDLLDLVLLSSLDLLTELFG---SSEAPSETKEGKSGKGTKAPKSLGSQF 540
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   654 RENLNKLMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIP 733
Cdd:cd14904  541 KTSLSQLMDNIKTTNTHYVRCIKPNANKSPTEFDKRMVVEQLRSAGVIEAIRITRSGYPSRLTPKELATRYAIMFPPSMH 620
                        650       660       670
                 ....*....|....*....|....*....|....*.
gi 6754774   734 EGqfiDSRKGAEKLLGSLDIDHN-QYKFGHTKVFFK 768
Cdd:cd14904  621 SK---DVRRTCSVFMTAIGRKSPlEYQIGKSLIYFK 653
MYSc_Myo46 cd14907
class XLVI myosin, motor domain; The class XLVI myosins are comprised of Alveolata. Not much ...
101-768 7.33e-139

class XLVI myosin, motor domain; The class XLVI myosins are comprised of Alveolata. Not much is known about this myosin class. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276872 [Multi-domain]  Cd Length: 669  Bit Score: 448.71  E-value: 7.33e-139
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   101 VLYNLKERYAAWMIYTYSGLFCVTVNPYKWLP-VYNAEVVAAYRGK--------KRSEAPPHIFSISDNAYQYMLTDREN 171
Cdd:cd14907    3 LLINLKKRYQQDKIFTYVGPTLIVMNPYKQIDnLFSEEVMQMYKEQiiqngeyfDIKKEPPHIYAIAALAFKQLFENNKK 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   172 QSILITGESGAGKTVNTKRVIQYFASIAA--------IGDRSKKENPNANKGTLEDQIIQANPALEAFGNAKTVRNDNSS 243
Cdd:cd14907   83 QAIVISGESGAGKTENAKYAMKFLTQLSQqeqnseevLTLTSSIRATSKSTKSIEQKILSCNPILEAFGNAKTVRNDNSS 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   244 RFGKFIRIHFG-ATGKLASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLDMLLVTNNP--YDYAFVSQGE-V 319
Cdd:cd14907  163 RFGKYVSILVDkKKRKILGARIQNYLLEKSRVTQQGQGERNYHIFYHLLYGADQQLLQQLGLKNQLsgDRYDYLKKSNcY 242
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   320 SVASIDDSEELLATDSAFDVLSFTAEEKAGVYKLTGAIMHYGNMKFKQKQ--REEQAEPDGTEDADKSAYLMGLNSADLL 397
Cdd:cd14907  243 EVDTINDEKLFKEVQQSFQTLGFTEEEQDSIWRILAAILLLGNLQFDDSTldDNSPCCVKNKETLQIIAKLLGIDEEELK 322
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   398 KGLCHPRVKVGNEYVTKGQSVQQVYYSIGALAKSVYEKMFNWMVTRINATL--------ETKQPRQYFIGVLDIAGFEIF 469
Cdd:cd14907  323 EALTTKIRKVGNQVITSPLSKKECINNRDSLSKELYDRLFNWLVERLNDTImpkdekdqQLFQNKYLSIGLLDIFGFEVF 402
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   470 DFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEF--IDFgMDLQACIDLIEK-PMGIMSILEEECMFPKASD 546
Cdd:cd14907  403 QNNSFEQLCINYTNEKLQQLYISYVFKAEEQEFKEEGLEDYLnqLSY-TDNQDVIDLLDKpPIGIFNLLDDSCKLATGTD 481
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   547 MTFKAKLYDNHlgksNNFQKPRNVKGKQEAHFSLVHYAGTVDYNIMGWLEKNKDPLNETVVGLYQKSSLKLMATLFSTya 626
Cdd:cd14907  482 EKLLNKIKKQH----KNNSKLIFPNKINKDTFTIRHTAKEVEYNIEGFREKNKDEISQSIINCIQNSKNRIISSIFSG-- 555
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   627 sADTGDSGKGKGGKKKGSSFQTVSALHRENLNKLMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRI 706
Cdd:cd14907  556 -EDGSQQQNQSKQKKSQKKDKFLGSKFRNQMKQLMNELMQCDVHFIRCIKPNEEKKADLFIQGYVLNQIRYLGVLESIRV 634
                        650       660       670       680       690       700
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6754774   707 CRKGFPNRILYGDFRQRYRILNpaaipegqfidsrkgaekllgsldidhNQYKFGHTKVFFK 768
Cdd:cd14907  635 RKQGYPYRKSYEDFYKQYSLLK---------------------------KNVLFGKTKIFMK 669
MYSc_Myo28 cd14889
class XXVIII myosin, motor domain; These myosins are found in fish, chicken, and mollusks. The ...
101-768 9.78e-137

class XXVIII myosin, motor domain; These myosins are found in fish, chicken, and mollusks. The tail regions of these class-XXVIII myosins consist of an IQ motif, a short coiled-coil region, and an SH2 domain. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276854  Cd Length: 659  Bit Score: 442.42  E-value: 9.78e-137
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   101 VLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYML----TDRENQSILI 176
Cdd:cd14889    3 LLEVLKVRFMQSNIYTYVGDILVAINPFKYLHIYEKEVSQKYKCEKKSSLPPHIFAVADRAYQSMLgrlaRGPKNQCIVI 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   177 TGESGAGKTVNTKRVIQYFASIAaigdrskkenpNANKgTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFgAT 256
Cdd:cd14889   83 SGESGAGKTESTKLLLRQIMELC-----------RGNS-QLEQQILQVNPLLEAFGNAQTVMNDNSSRFGKYIQLRF-RN 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   257 GKLASADIETYLLEKSRVIFQLKAERNYHIFYQI---LSNKKPELLDMLLVTNNPY-DYAFVSQGEVSVASIDDSEELla 332
Cdd:cd14889  150 GHVKGAKINEYLLEKSRVVHQDGGEENFHIFYYMfagISAEDRENYGLLDPGKYRYlNNGAGCKREVQYWKKKYDEVC-- 227
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   333 tdSAFDVLSFTAEEKAGVYKLTGAIMHYGNMKFKQKQREE-QAEPDGTEDADKSAYLMGLNSADLLKGLCHPRVKVGNEY 411
Cdd:cd14889  228 --NAMDMVGFTEQEEVDMFTILAGILSLGNITFEMDDDEAlKVENDSNGWLKAAAGQFGVSEEDLLKTLTCTVTFTRGEQ 305
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   412 VTKGQSVQQVYYSIGALAKSVYEKMFNWMVTRINATLETKQPRQY---FIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQ 488
Cdd:cd14889  306 IQRHHTKQQAEDARDSIAKVAYGRVFGWIVSKINQLLAPKDDSSVelrEIGILDIFGFENFAVNRFEQACINLANEQLQY 385
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   489 FFNHHMFVLEQEEYKKEGIEWEFIDFgMDLQACIDL-IEKPMGIMSILEEECMFPKASDMTFKAKLyDNHLGKSNNFQKP 567
Cdd:cd14889  386 FFNHHIFLMEQKEYKKEGIDWKEITY-KDNKPILDLfLNKPIGILSLLDEQSHFPQATDESFVDKL-NIHFKGNSYYGKS 463
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   568 RNVKGKqeahFSLVHYAGTVDYNIMGWLEKNKDPLNETVVGLYQKSSLKLMATLFSTYASADTGDSGKGKGGKKKGSSF- 646
Cdd:cd14889  464 RSKSPK----FTVNHYAGKVTYNASGFLEKNRDTIPASIRTLFINSATPLLSVLFTATRSRTGTLMPRAKLPQAGSDNFn 539
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   647 ----QTVSALHRENLNKLMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQ 722
Cdd:cd14889  540 strkQSVGAQFKHSLGVLMEKMFAASPHFVRCIKPNHVKVPGQLDSKYIQDQLRYNGLLETIRIRREGFSWRPSFAEFAE 619
                        650       660       670       680
                 ....*....|....*....|....*....|....*....|....*..
gi 6754774   723 RYRIL-NPAAIPegqfiDSRKGAEKLLGSLDIdhNQYKFGHTKVFFK 768
Cdd:cd14889  620 RYKILlCEPALP-----GTKQSCLRILKATKL--VGWKCGKTRLFFK 659
MYSc_Myo30 cd14891
class XXX myosin, motor domain; Myosins of class XXX are composed of an amino-terminal ...
99-768 5.74e-135

class XXX myosin, motor domain; Myosins of class XXX are composed of an amino-terminal SH3-like domain, two IQ motifs, a coiled-coil region and a PX domain. The myosin classes XXX to XXXIV contain members from Phytophthora species and Hyaloperonospora parasitica. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276856  Cd Length: 645  Bit Score: 436.78  E-value: 5.74e-135
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    99 PAVLYNLKERYAA--WMIYTYSGLFCVTVNPYKWLPvyNAEVvAAYRGKKRSEAPPHIFSISDNAYQYMLTDRE---NQS 173
Cdd:cd14891    1 AGILHNLEERSKLdnQRPYTFMANVLIAVNPLRRLP--EPDK-SDYINTPLDPCPPHPYAIAEMAYQQMCLGSGrmqNQS 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   174 ILITGESGAGKTVNTKRVIQYFASIAAIGDRSKKENPNANKG-------TLEDQIIQANPALEAFGNAKTVRNDNSSRFG 246
Cdd:cd14891   78 IVISGESGAGKTETSKIILRFLTTRAVGGKKASGQDIEQSSKkrklsvtSLDERLMDTNPILESFGNAKTLRNHNSSRFG 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   247 KFIRIHFGATG-KLASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLDMLLVTnNPYDYAFVSQ-GEVSVASI 324
Cdd:cd14891  158 KFMKLQFTKDKfKLAGAFIETYLLEKSRLVAQPPGERNFHIFYQLLAGASAELLKELLLL-SPEDFIYLNQsGCVSDDNI 236
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   325 DDSEELLATDSAFDVLSFTAEEKAGVYKLTGAIMHYGNMKFKQKQREE----QAEPDGTEDADKSAYLMGLNSADLLKGL 400
Cdd:cd14891  237 DDAANFDNVVSALDTVGIDEDLQLQIWRILAGLLHLGNIEFDEEDTSEgeaeIASESDKEALATAAELLGVDEEALEKVI 316
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   401 CHPRVKVGNEYVTKGQSVQQVYYSIGALAKSVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFD-FNSFEQLCI 479
Cdd:cd14891  317 TQREIVTRGETFTIKRNAREAVYSRDAIAKSIYERLFLWIVQQINTSLGHDPDPLPYIGVLDIFGFESFEtKNDFEQLLI 396
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   480 NFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGmDLQACIDLI-EKPMGIMSILEEECMFPKASDMTFKAKLYDNHl 558
Cdd:cd14891  397 NYANEALQATFNQQVFIAEQELYKSEGIDVGVITWP-DNRECLDLIaSKPNGILPLLDNEARNPNPSDAKLNETLHKTH- 474
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   559 GKSNNFQKPRNvKGKQEAhFSLVHYAGTVDYNIMGWLEKNKDPLNEtvvglyQKSSLKLMATLFStyasadtgdsgkgkg 638
Cdd:cd14891  475 KRHPCFPRPHP-KDMREM-FIVKHYAGTVSYTIGSFIDKNNDIIPE------DFEDLLASSAKFS--------------- 531
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   639 gkkkgssfqtvsalhrENLNKLMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYG 718
Cdd:cd14891  532 ----------------DQMQELVDTLEATRCNFIRCIKPNAAMKVGVFDNRYVVDQLRCSGILQTCEVLKVGLPTRVTYA 595
                        650       660       670       680       690
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 6754774   719 DFRQRYRILNPAAI------PEGQFIdsrkgaEKLLGSLDIDHNQYKFGHTKVFFK 768
Cdd:cd14891  596 ELVDVYKPVLPPSVtrlfaeNDRTLT------QAILWAFRVPSDAYRLGRTRVFFR 645
MYSc_Myo47 cd14908
class XLVII myosin, motor domain; The class XLVII myosins are comprised of Stramenopiles. Not ...
99-729 1.48e-134

class XLVII myosin, motor domain; The class XLVII myosins are comprised of Stramenopiles. Not much is known about this myosin class. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276873 [Multi-domain]  Cd Length: 682  Bit Score: 437.03  E-value: 1.48e-134
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    99 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYR--GKKRS---EAP----PHIFSISDNAYQYMLTD- 168
Cdd:cd14908    1 PAILHSLSRRFFRGIIYTWTGPVLIAVNPFQRLPLYGKEILESYRqeGLLRSqgiESPqalgPHVFAIADRSYRQMMSEi 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   169 RENQSILITGESGAGKTVNTKRVIQYFASIAAIGDRSKKENPNANKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKF 248
Cdd:cd14908   81 RASQSILISGESGAGKTESTKIVMLYLTTLGNGEEGAPNEGEELGKLSIMDRVLQSNPILEAFGNARTLRNDNSSRFGKF 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   249 IRIHFGATGKLASADIETYLLEKSRVIFQLKAERNYHIFYQIL------SNKKPELLDMLLVTNN-PYDYAFVSQGEV-S 320
Cdd:cd14908  161 IELGFNRAGNLLGAKVQTYLLEKVRLPFHASGERNYHIFYQLLrggdeeEHEKYEFHDGITGGLQlPNEFHYTGQGGApD 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   321 VASIDDSEELLATDSAFDVLSFTAEEKAGVYKLTGAIMHYGNMKFKQKQREEQAEPDGTEDADKSAY---LMGLNSADLL 397
Cdd:cd14908  241 LREFTDEDGLVYTLKAMRTMGWEESSIDTILDIIAGLLHLGQLEFESKEEDGAAEIAEEGNEKCLARvakLLGVDVDKLL 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   398 KGLCHPRVKVGNEYVTKGQSVQQVYYSIGALAKSVYEKMFNWMVTRINATL--ETKQPRQYFIGVLDIAGFEIFDFNSFE 475
Cdd:cd14908  321 RALTSKIIVVRGKEITTKLTPHKAYDARDALAKTIYGALFLWVVATVNSSInwENDKDIRSSVGVLDIFGFECFAHNSFE 400
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   476 QLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGmDLQACIDLIE-KPMGIMSILEEECMFP-KASDMTFKAKL 553
Cdd:cd14908  401 QLCINFTNEALQQQFNQFIFKLEQKEYEKESIEWAFIEFP-DNQDCLDTIQaKKKGILTMLDDECRLGiRGSDANYASRL 479
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   554 YDNHLGKSNN-------FQKPRNVKGKqeAHFSLVHYAGTVDYNI-MGWLEKNKDPLNETVVGLYQKSslklmaTLFsty 625
Cdd:cd14908  480 YETYLPEKNQthsentrFEATSIQKTK--LIFAVRHFAGQVQYTVeTTFCEKNKDEIPLTADSLFESG------QQF--- 548
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   626 asadtgdsgkgkggkkkgssfqtvsalhRENLNKLMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIR 705
Cdd:cd14908  549 ----------------------------KAQLHSLIEMIEDTDPHYIRCIKPNDAAKPDLVTRKRVTEQLRYGGVLEAVR 600
                        650       660
                 ....*....|....*....|....
gi 6754774   706 ICRKGFPNRILYGDFRQRYRILNP 729
Cdd:cd14908  601 VARSGYPVRLPHKDFFKRYRMLLP 624
MYSc_Myo41 cd14902
class XLI myosin, motor domain; The class XLI myosins are comprised of Stramenopiles. Not much ...
99-729 3.19e-133

class XLI myosin, motor domain; The class XLI myosins are comprised of Stramenopiles. Not much is known about this myosin class. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276867 [Multi-domain]  Cd Length: 716  Bit Score: 434.32  E-value: 3.19e-133
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    99 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLP-VYNAEVVAAYR--------GKKRSEAPPHIFSISDNAYQYML-TD 168
Cdd:cd14902    1 AALLQALSERFEHDQIYTSIGDILVALNPLKPLPdLYSESQLNAYKasmtstspVSQLSELPPHVFAIGGKAFGGLLkPE 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   169 RENQSILITGESGAGKTVNTKRVIQYFASIAAigDRSKKENPNANKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKF 248
Cdd:cd14902   81 RRNQSILVSGESGSGKTESTKFLMQFLTSVGR--DQSSTEQEGSDAVEIGKRILQTNPILESFGNAQTIRNDNSSRFGKF 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   249 IRIHFGATGKLASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLDmLLVTNNPYDYAFVSQGEVSVA-----S 323
Cdd:cd14902  159 IKIQFGANNEIVGAQIVSYLLEKVRLLHQSPEERSFHIFYELLEGADKTLLD-LLGLQKGGKYELLNSYGPSFArkravA 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   324 IDDSEELLATDSAFDVLSFTAEEKAGVYKLTGAIMHYGNMKFKQKQREEQAEPDGTEDA---DKSAYLMGLNSADLLKGL 400
Cdd:cd14902  238 DKYAQLYVETVRAFEDTGVGELERLDIFKILAALLHLGNVNFTAENGQEDATAVTAASRfhlAKCAELMGVDVDKLETLL 317
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   401 CHPRVKVGNEYVTKGQSVQQVYYSIGALAKSVYEKMFNWMVTRIN-------ATLETKQPRQYF--IGVLDIAGFEIFDF 471
Cdd:cd14902  318 SSREIKAGVEVMVLKLTPEQAKEICGSLAKAIYGRLFTWLVRRLSdeinyfdSAVSISDEDEELatIGILDIFGFESLNR 397
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   472 NSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLqACIDLIE-KPMGIMSILEEECMFPKASDMTFK 550
Cdd:cd14902  398 NGFEQLCINYANERLQAQFNEFVFVKEQQIYIAEGIDWKNISYPSNA-ACLALFDdKSNGLFSLLDQECLMPKGSNQALS 476
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   551 AKLYDNHLGksnnfqkprnvkgkqEAHFSLVHYAGTVDYNIMGWLEKNKDPLNETVVGLYQKSSLKLMATLFSTYASADT 630
Cdd:cd14902  477 TKFYRYHGG---------------LGQFVVHHFAGRVCYNVEQFVEKNTDALPADASDILSSSSNEVVVAIGADENRDSP 541
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   631 G-DSGKGKGGKKKGSSFQTVSALHRENLNKLMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRK 709
Cdd:cd14902  542 GaDNGAAGRRRYSMLRAPSVSAQFKSQLDRLIVQIGRTEAHYVRCLKPNEVKKPGIFDRERMVEQMRSVGVLEAVRIARH 621
                        650       660
                 ....*....|....*....|
gi 6754774   710 GFPNRILYGDFRQRYRILNP 729
Cdd:cd14902  622 GYSVRLAHASFIELFSGFKC 641
PTZ00014 PTZ00014
myosin-A; Provisional
62-821 6.90e-125

myosin-A; Provisional


Pssm-ID: 240229 [Multi-domain]  Cd Length: 821  Bit Score: 414.43  E-value: 6.90e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     62 ETENGKTVTIKEDQVMQQNPP-KFDKIEDMAMLTFLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVA 140
Cdd:PTZ00014   72 DPPTNSTFEVKPEHAFNANSQiDPMTYGDIGLLPHTNIPCVLDFLKHRYLKNQIYTTADPLLVAINPFKDLGNTTNDWIR 151
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    141 AYR-GKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFASiaaigdrSKKENpnaNKGTLED 219
Cdd:PTZ00014  152 RYRdAKDSDKLPPHVFTTARRALENLHGVKKSQTIIVSGESGAGKTEATKQIMRYFAS-------SKSGN---MDLKIQN 221
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    220 QIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELL 299
Cdd:PTZ00014  222 AIMAANPVLEAFGNAKTIRNNNSSRFGRFMQLQLGEEGGIRYGSIVAFLLEKSRVVTQEDDERSYHIFYQLLKGANDEMK 301
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    300 DMLLVTNNPyDYAFVSQGEVSVASIDDSEELLATDSAFDVLSFTAEEKAGVYKLTGAIMHYGNMKFKQKqrEEQAEPDGT 379
Cdd:PTZ00014  302 EKYKLKSLE-EYKYINPKCLDVPGIDDVKDFEEVMESFDSMGLSESQIEDIFSILSGVLLLGNVEIEGK--EEGGLTDAA 378
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    380 EDADKS-------AYLMGLNSADLLKGLCHPRVKVGNEYVTKGQSVQQVYYSIGALAKSVYEKMFNWMVTRINATLETKQ 452
Cdd:PTZ00014  379 AISDESlevfneaCELLFLDYESLKKELTVKVTYAGNQKIEGPWSKDESEMLKDSLSKAVYEKLFLWIIRNLNATIEPPG 458
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    453 PRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLQACIDLIEKPMGIM 532
Cdd:PTZ00014  459 GFKVFIGMLDIFGFEVFKNNSLEQLFINITNEMLQKNFVDIVFERESKLYKDEGISTEELEYTSNESVIDLLCGKGKSVL 538
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    533 SILEEECMFPKASDMTFKAKLYDNHlgKSNNFQKPrnVKGKQEAHFSLVHYAGTVDYNIMGWLEKNKDPLNETVVGLYQK 612
Cdd:PTZ00014  539 SILEDQCLAPGGTDEKFVSSCNTNL--KNNPKYKP--AKVDSNKNFVIKHTIGDIQYCASGFLFKNKDVLRPELVEVVKA 614
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    613 SSLKLMATLFStyasadtGDSGKGKGGKKKgssfQTVSALHRENLNKLMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVM 692
Cdd:PTZ00014  615 SPNPLVRDLFE-------GVEVEKGKLAKG----QLIGSQFLNQLDSLMSLINSTEPHFIRCIKPNENKKPLDWNSSKVL 683
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    693 HQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNpAAIPEGQFIDSRKGAEKLLGSLDIDHNQYKFGHTKVFFKAGLL 772
Cdd:PTZ00014  684 IQLHSLSILEALQLRQLGFSYRRTFAEFLSQFKYLD-LAVSNDSSLDPKEKAEKLLERSGLPKDSYAIGKTMVFLKKDAA 762
                         730       740       750       760       770
                  ....*....|....*....|....*....|....*....|....*....|..
gi 6754774    773 GLLEEMRDERLSR---IITRIQAQARGQLMRIEFKKIVErrdALLVIQWNIR 821
Cdd:PTZ00014  763 KELTQIQREKLAAwepLVSVLEALILKIKKKRKVRKNIK---SLVRIQAHLR 811
MYSc_Myo35 cd14896
class XXXV myosin, motor domain; This class of metazoan myosins contains 2 IQ motifs, 2 MyTH4 ...
99-768 9.43e-125

class XXXV myosin, motor domain; This class of metazoan myosins contains 2 IQ motifs, 2 MyTH4 domains, a single FERM domain, and an SH3 domain. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276861 [Multi-domain]  Cd Length: 644  Bit Score: 408.01  E-value: 9.43e-125
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    99 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITG 178
Cdd:cd14896    1 SSVLLCLKKRFHLGRIYTFGGPILLSLNPHRSLPLFSEEVLASYHPRKALNTTPHIFAIAASAYRLSQSTGQDQCILLSG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   179 ESGAGKTVNTKRVIQYFASIaaigdrsKKENPNANKGTLEDQIiqanPALEAFGNAKTVRNDNSSRFGKFIRIHFgATGK 258
Cdd:cd14896   81 HSGSGKTEAAKKIVQFLSSL-------YQDQTEDRLRQPEDVL----PILESFGHAKTILNANASRFGQVLRLHL-QHGV 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   259 LASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLDMLLVtNNPYDYAFVSQGEV-SVASIDDSEELLATDSAF 337
Cdd:cd14896  149 IVGASVSHYLLETSRVVFQAQAERSFHVFYELLAGLDPEEREQLSL-QGPETYYYLNQGGAcRLQGKEDAQDFEGLLKAL 227
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   338 DVLSFTAEEKAGVYKLTGAIMHYGNMKFKQKQREEQAEPDGTEDAD--KSAYLMGLnSADLLKGLCHPRVKVGN-EYVTK 414
Cdd:cd14896  228 QGLGLCAEELTAIWAVLAAILQLGNICFSSSERESQEVAAVSSWAEihTAARLLQV-PPERLEGAVTHRVTETPyGRVSR 306
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   415 GQSVQQVYYSIGALAKSVYEKMFNWMVTRINATLETKQPRQYF--IGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNH 492
Cdd:cd14896  307 PLPVEGAIDARDALAKTLYSRLFTWLLKRINAWLAPPGEAESDatIGVVDAYGFEALRVNGLEQLCINLASERLQLFSSQ 386
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   493 HMFVLEQEEYKKEGIEWEFIDfGMDLQACIDLI-EKPMGIMSILEEECMFPKASDMTFKAKLYDNHlGKSNNFQKPRNvk 571
Cdd:cd14896  387 TLLAQEEEECQRELLPWVPIP-QPPRESCLDLLvDQPHSLLSILDDQTWLSQATDHTFLQKCHYHH-GDHPSYAKPQL-- 462
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   572 gkQEAHFSLVHYAGTVDYNIMGWLEKNKDPLNETVVGLYQKSSLKLMATLFSTyASADTGDSGKGKggkkkgssfqTVSA 651
Cdd:cd14896  463 --PLPVFTVRHYAGTVTYQVHKFLNRNRDQLDPAVVEMLAQSQLQLVGSLFQE-AEPQYGLGQGKP----------TLAS 529
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   652 LHRENLNKLMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILnpAA 731
Cdd:cd14896  530 RFQQSLGDLTARLGRSHVYFIHCLNPNPGKLPGLFDVGHVTEQLRQAGILEAIGTRSEGFPVRVPFQAFLARFGAL--GS 607
                        650       660       670
                 ....*....|....*....|....*....|....*..
gi 6754774   732 IPEGQFIDSRKGAEKLLGSLDIDHNQYKFGHTKVFFK 768
Cdd:cd14896  608 ERQEALSDRERCGAILSQVLGAESPLYHLGATKVLLK 644
MYSc_Myo34 cd14895
class XXXIV myosin, motor domain; Class XXXIV myosins are composed of an IQ motif, a short ...
99-768 2.83e-121

class XXXIV myosin, motor domain; Class XXXIV myosins are composed of an IQ motif, a short coiled-coil region, 5 tandem ANK repeats, and a carboxy-terminal FYVE domain. The myosin classes XXX to XXXIV contain members from Phytophthora species and Hyaloperonospora parasitica. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276860 [Multi-domain]  Cd Length: 704  Bit Score: 400.48  E-value: 2.83e-121
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    99 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLP-VYNaevVAAYRGK--KRSEAPPHIFSISDNAYQYMLT-------D 168
Cdd:cd14895    1 PAFVDYLAQRYGVDQVYCRSGAVLIAVNPFKHIPgLYD---LHKYREEmpGWTALPPHVFSIAEGAYRSLRRrlhepgaS 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   169 RENQSILITGESGAGKTVNTKRVIQYFA----SIAAIGDRSKKENPNAnkgtleDQIIQANPALEAFGNAKTVRNDNSSR 244
Cdd:cd14895   78 KKNQTILVSGESGAGKTETTKFIMNYLAesskHTTATSSSKRRRAISG------SELLSANPILESFGNARTLRNDNSSR 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   245 FGKFIRIHFG-----ATGKLASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLDML-LVTNNPYDYAFVSQGE 318
Cdd:cd14895  152 FGKFVRMFFEgheldTSLRMIGTSVETYLLEKVRVVHQNDGERNFHVFYELLAGAADDMKLELqLELLSAQEFQYISGGQ 231
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   319 VSVAS--IDDSEELLATDSAFDVLSFTAEEKAGVYKLTGAIMHYGNMKFKQKQREEQAEPDGTEDA-------------- 382
Cdd:cd14895  232 CYQRNdgVRDDKQFQLVLQSMKVLGFTDVEQAAIWKILSALLHLGNVLFVASSEDEGEEDNGAASApcrlasaspssltv 311
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   383 ----DKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQSVQQVYYSIGALAKSVYEKMFNWMVTRINATLETKQPRQY-- 456
Cdd:cd14895  312 qqhlDIVSKLFAVDQDELVSALTTRKISVGGETFHANLSLAQCGDARDAMARSLYAFLFQFLVSKVNSASPQRQFALNpn 391
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   457 ---------FIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGmDLQACIDLIE- 526
Cdd:cd14895  392 kaankdttpCIAVLDIFGFEEFEVNQFEQFCINYANEKLQYQFIQDILLTEQQAHIEEGIKWNAVDYE-DNSVCLEMLEq 470
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   527 KPMGIMSILEEECMFPKASDMTFKAKLYdNHLGKSNNFQKPRnvKGKQEAHFSLVHYAGTVDYNIMGWLEKNKDPLNETV 606
Cdd:cd14895  471 RPSGIFSLLDEECVVPKGSDAGFARKLY-QRLQEHSNFSASR--TDQADVAFQIHHYAGAVRYQAEGFCEKNKDQPNAEL 547
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   607 VGLYQKSSLKLMATLFSTYASADTGDSGKGKGGKKKGSSFQT---VSALHRENLNKLMTNLKTTHPHFVRCIIPNERKAP 683
Cdd:cd14895  548 FSVLGKTSDAHLRELFEFFKASESAELSLGQPKLRRRSSVLSsvgIGSQFKQQLASLLDVVQQTQTHYIRCIKPNDESAS 627
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   684 GVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPegqfidSRKGAEKLLGSLDIDHNQykFGHT 763
Cdd:cd14895  628 DQFDMAKVSSQLRYGGVLKAVEIMRQSYPVRMKHADFVKQYRLLVAAKNA------SDATASALIETLKVDHAE--LGKT 699

                 ....*
gi 6754774   764 KVFFK 768
Cdd:cd14895  700 RVFLR 704
MYSc_Myo14 cd14876
class XIV myosin, motor domain; These myosins localize to plasma membranes of the ...
99-768 4.11e-119

class XIV myosin, motor domain; These myosins localize to plasma membranes of the intracellular parasites and may be involved in the cell invasion process. Their known functions include: transporting phagosomes to the nucleus and perturbing the developmentally regulated elimination of the macronucleus during conjugation. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. C-terminal to their motor domain these myosins have a MyTH4-FERM protein domain combination. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276843  Cd Length: 649  Bit Score: 392.04  E-value: 4.11e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    99 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRG-KKRSEAPPHIFSIS----DNAYQYmltdRENQS 173
Cdd:cd14876    1 PCVLDFLKHRYLKNQIYTTADPLLVAINPFKDLGNATDEWIRKYRDaPDLTKLPPHVFYTArralENLHGV----NKSQT 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   174 ILITGESGAGKTVNTKRVIQYFASiaaigdrSKKENPNankGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHF 253
Cdd:cd14876   77 IIVSGESGAGKTEATKQIMRYFAS-------AKSGNMD---LRIQTAIMAANPVLEAFGNAKTIRNNNSSRFGRFMQLDV 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   254 GATGKLASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLD--MLLVTNnpyDYAFVSQGEVSVASIDDSEELL 331
Cdd:cd14876  147 ASEGGIRYGSVVAFLLEKSRIVTQDDNERSYHIFYQLLKGADSEMKSkyHLLGLK---EYKFLNPKCLDVPGIDDVADFE 223
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   332 ATDSAFDVLSFTAEEKAGVYKLTGAIMHYGNMKFKQKQReeqaepDGTEDA-----------DKSAYLMGLNSADLLKGL 400
Cdd:cd14876  224 EVLESLKSMGLTEEQIDTVFSIVSGVLLLGNVKITGKTE------QGVDDAaaisneslevfKEACSLLFLDPEALKREL 297
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   401 CHPRVKVGNEYVTKGQSVQQVYYSIGALAKSVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCIN 480
Cdd:cd14876  298 TVKVTKAGGQEIEGRWTKDDAEMLKLSLAKAMYDKLFLWIIRNLNSTIEPPGGFKNFMGMLDIFGFEVFKNNSLEQLFIN 377
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   481 FTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKASDMTFKAKLYDNHlgK 560
Cdd:cd14876  378 ITNEMLQKNFIDIVFERESKLYKDEGIPTAELEYTSNAEVIDVLCGKGKSVLSILEDQCLAPGGSDEKFVSACVSKL--K 455
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   561 SNNFQKPrnVKGKQEAHFSLVHYAGTVDYNIMGWLEKNKDPLNETVVGLYQKSSLKLMATLFstyasadtgdsGKGKGGK 640
Cdd:cd14876  456 SNGKFKP--AKVDSNINFIVVHTIGDIQYNAEGFLFKNKDVLRAELVEVVQASTNPVVKALF-----------EGVVVEK 522
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   641 KKGSSFQTVSALHRENLNKLMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDF 720
Cdd:cd14876  523 GKIAKGSLIGSQFLKQLESLMGLINSTEPHFIRCIKPNETKKPLEWNSSKVLIQLHALSILEALQLRQLGYSYRRPFEEF 602
                        650       660       670       680
                 ....*....|....*....|....*....|....*....|....*...
gi 6754774   721 RQRYRILNPaAIPEGQFIDSRKGAEKLLGSLDIDHNQYKFGHTKVFFK 768
Cdd:cd14876  603 LYQFKFLDL-GIANDKSLDPKVAALKLLESSGLSEDEYAIGKTMVFLK 649
MYSc_Myo19 cd14880
class XIX myosin, motor domain; Monomeric myosin-XIX (Myo19) functions as an actin-based motor ...
101-729 1.04e-110

class XIX myosin, motor domain; Monomeric myosin-XIX (Myo19) functions as an actin-based motor for mitochondrial movement in vertebrate cells. It contains a variable number of IQ domains. Human myo19 contains a motor domain, three IQ motifs, and a short tail. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276846 [Multi-domain]  Cd Length: 658  Bit Score: 368.41  E-value: 1.04e-110
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   101 VLYNLKERYAAWMIYTYSGLFCVTVNPYKWLP-VYNAEVVAAYRGKKRSEA-PPHIFSISDNAYQYMLTDRE--NQSILI 176
Cdd:cd14880    3 VLRCLQARYTADTFYTNAGCTLVALNPFKPVPqLYSPELMREYHAAPQPQKlKPHIFTVGEQTYRNVKSLIEpvNQSIVV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   177 TGESGAGKTVNTKRVIQYFASIAAiGDRSKKENPNANKgtLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGAT 256
Cdd:cd14880   83 SGESGAGKTWTSRCLMKFYAVVAA-SPTSWESHKIAER--IEQRILNSNPVMEAFGNACTLRNNNSSRFGKFIQLQLNRA 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   257 GKLASADIETYLLEKSRVIFQLKAERNYHIFYQILsnkKPELLDMLLVTNNP--YDYAFVSQGEVSVASiDDSEellATD 334
Cdd:cd14880  160 QQMTGAAVQTYLLEKTRVACQAPSERNFHIFYQIC---KGASADERLQWHLPegAAFSWLPNPERNLEE-DCFE---VTR 232
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   335 SAFDVLSFTAEEKAGVYKLTGAIMHYGNMKFKQKQREEQA---EPDGTEDADKSAYLMGLNSADLLKGLCHPRVKVGNEY 411
Cdd:cd14880  233 EAMLHLGIDTPTQNNIFKVLAGLLHLGNIQFADSEDEAQPcqpMDDTKESVRTSALLLKLPEDHLLETLQIRTIRAGKQQ 312
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   412 VT--KGQSVQQVYYSIGALAKSVYEKMFNWMVTRINATLETKQPR-QYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQ 488
Cdd:cd14880  313 QVfkKPCSRAECDTRRDCLAKLIYARLFDWLVSVINSSICADTDSwTTFIGLLDVYGFESFPENSLEQLCINYANEKLQQ 392
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   489 FFNHHMFVLEQEEYKKEGIEWEFIDFgMDLQACIDLIE-KPMGIMSILEEECMFPKASDmtfkAKLYDNHLGK--SNNFQ 565
Cdd:cd14880  393 HFVAHYLRAQQEEYAVEGLEWSFINY-QDNQTCLDLIEgSPISICSLINEECRLNRPSS----AAQLQTRIESalAGNPC 467
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   566 KPRNvKGKQEAHFSLVHYAGTVDYNIMGWLEKNKDPLNETVVGLYQKSSLKLMATLFstyaSADTGDSGKGKGGKKKGSS 645
Cdd:cd14880  468 LGHN-KLSREPSFIVVHYAGPVRYHTAGLVEKNKDPVPPELTRLLQQSQDPLLQKLF----PANPEEKTQEEPSGQSRAP 542
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   646 FQTVSALHRENLNKLMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYR 725
Cdd:cd14880  543 VLTVVSKFKASLEQLLQVLHSTTPHYIRCIKPNSQCQAQTFLQEEVLSQLEACGLVETIHISAAGFPIRVSHQNFVERYK 622

                 ....
gi 6754774   726 ILNP 729
Cdd:cd14880  623 LLRR 626
MYSc_Myo45 cd14906
class XLV myosin, motor domain; The class XLVI myosins are comprised of slime molds ...
101-728 2.34e-108

class XLV myosin, motor domain; The class XLVI myosins are comprised of slime molds Dictyostelium and Polysphondylium. Not much is known about this myosin class. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276871 [Multi-domain]  Cd Length: 715  Bit Score: 363.53  E-value: 2.34e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   101 VLYNLKERYAAWMIYTYSGLFCVTVNPYKWLP-VYNAEVVAAYRGKKR-SEAPPHIFSISDNAYQYMLTDRENQSILITG 178
Cdd:cd14906    3 ILNNLGKRYKSDSIYTYIGNVLISINPYKDISsIYSNLILNEYKDINQnKSPIPHIYAVALRAYQSMVSEKKNQSIIISG 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   179 ESGAGKTVNTKRVIQYFASIAAiGDRSKKENPNANKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGAT-G 257
Cdd:cd14906   83 ESGSGKTEASKTILQYLINTSS-SNQQQNNNNNNNNNSIEKDILTSNPILEAFGNSRTTKNHNSSRFGKFLKIEFRSSdG 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   258 KLASADIETYLLEKSRVIFQL-KAERNYHIFYQILSNKKPELLDMLLVTNNPYDYAFVSQGEVSVASI------------ 324
Cdd:cd14906  162 KIDGASIETYLLEKSRISHRPdNINLSYHIFYYLVYGASKDERSKWGLNNDPSKYRYLDARDDVISSFksqssnknsnhn 241
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   325 ---DDSEELLATDSAFDVLSFTAEEKAGVYKLTGAIMHYGNMKFKQKQ---REEQAEPDGTEDADKSAYLMGLNSADLLK 398
Cdd:cd14906  242 nktESIESFQLLKQSMESMSINKEQCDAIFLSLAAILHLGNIEFEEDSdfsKYAYQKDKVTASLESVSKLLGYIESVFKQ 321
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   399 GLCHPRVKVGNE--YVTKGQSVQQVYYSIGALAKSVYEKMFNWMVTRINAT-LETKQPRQ----------YFIGVLDIAG 465
Cdd:cd14906  322 ALLNRNLKAGGRgsVYCRPMEVAQSEQTRDALSKSLYVRLFKYIVEKINRKfNQNTQSNDlaggsnkknnLFIGVLDIFG 401
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   466 FEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFgMDLQACIDLIE-KPMGIMSILEEECMFPKA 544
Cdd:cd14906  402 FENLSSNSLEQLLINFTNEKLQQQFNLNVFENEQKEYLSEGIPWSNSNF-IDNKECIELIEkKSDGILSLLDDECIMPKG 480
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   545 SDMTFKAKlYDNHLGKSNNFQKPRNVKGKqeahFSLVHYAGTVDYNIMGWLEKNKDPLNETVVGLYQKSSLKLMATLFST 624
Cdd:cd14906  481 SEQSLLEK-YNKQYHNTNQYYQRTLAKGT----LGIKHFAGDVTYQTDGWLEKNRDSLYSDVEDLLLASSNFLKKSLFQQ 555
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   625 YASADTGDSGKGKGGKkkgssfqTVSALHRENLNKLMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGI 704
Cdd:cd14906  556 QITSTTNTTKKQTQSN-------TVSGQFLEQLNQLIQTINSTSVHYIRCIKPNQTMDCNNFNNVHVLSQLRNVGVLNTI 628
                        650       660
                 ....*....|....*....|....
gi 6754774   705 RICRKGFPNRILYGDFRQRYRILN 728
Cdd:cd14906  629 KVRKMGYSYRRDFNQFFSRYKCIV 652
MYSc_Myo38 cd14899
class XXXVIII myosin; The class XXXVIII myosins are comprised of Stramenopiles. Not much is ...
100-725 1.38e-106

class XXXVIII myosin; The class XXXVIII myosins are comprised of Stramenopiles. Not much is known about this myosin class. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276864 [Multi-domain]  Cd Length: 717  Bit Score: 358.64  E-value: 1.38e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   100 AVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLP-VYNAEVVAAYR-------GKKRSEA---PPHIFSISDNAYQYMLTD 168
Cdd:cd14899    2 SILNALRLRYERHAIYTHIGDILISINPFQDLPqLYGDEILRGYAydhnsqfGDRVTSTdprEPHLFAVARAAYIDIVQN 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   169 RENQSILITGESGAGKTVNTKRVIQYFA------SIAAIGDRSKKENPNANKGTLEDQIIQANPALEAFGNAKTVRNDNS 242
Cdd:cd14899   82 GRSQSILISGESGAGKTEATKIIMTYFAvhcgtgNNNLTNSESISPPASPSRTTIEEQVLQSNPILEAFGNARTVRNDNS 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   243 SRFGKFIRIHF-GATGKLASADIETYLLEKSRVIFQLKAERNYHIFYQILSNK----KPELLDMLLVTNNPYDYAFVSQG 317
Cdd:cd14899  162 SRFGKFIELRFrDERRRLAGARIRTYLLEKIRVIKQAPHERNFHIFYELLSADnncvSKEQKQVLALSGGPQSFRLLNQS 241
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   318 EVSVA--SIDDSEELLATDSAFDVLSFTAEEKAGVYKLTGAIMHYGNMKFKQ--KQREEQAEPDGTEDA----------D 383
Cdd:cd14899  242 LCSKRrdGVKDGVQFRATKRAMQQLGMSEGEIGGVLEIVAAVLHMGNVDFEQipHKGDDTVFADEARVMssttgafdhfT 321
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   384 KSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQSVQQVYYSIGALAKSVYEKMFNWMVTRINATLETKQPRQY------- 456
Cdd:cd14899  322 KAAELLGVSTEALDHALTKRWLHASNETLVVGVDVAHARNTRNALTMECYRLLFEWLVARVNNKLQRQASAPWgadesdv 401
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   457 --------FIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDlQACIDLIE-K 527
Cdd:cd14899  402 ddeedatdFIGLLDIFGFEDMAENSFEQLCINYANEALQHQFNQYIFEEEQRLYRDEGIRWSFVDFPNN-RACLELFEhR 480
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   528 PMGIMSILEEECMFPKASDMTFKAKLYDNHLGKSNNFQKPRNVKGKQEAHFSLVHYAGTVDYNIMGWLEKNKDPLNETVV 607
Cdd:cd14899  481 PIGIFSLTDQECVFPQGTDRALVAKYYLEFEKKNSHPHFRSAPLIQRTTQFVVAHYAGCVTYTIDGFLAKNKDSFCESAA 560
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   608 GLYQKSSLKLMATLFSTYASAD-TGDSGKGKGGKKKGSSFQT------VSALHRENLNKLMTNLKTTHPHFVRCIIPNER 680
Cdd:cd14899  561 QLLAGSSNPLIQALAAGSNDEDaNGDSELDGFGGRTRRRAKSaiaavsVGTQFKIQLNELLSTVRATTPRYVRCIKPNDS 640
                        650       660       670       680
                 ....*....|....*....|....*....|....*....|....*
gi 6754774   681 KAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYR 725
Cdd:cd14899  641 HVGSLFQSTRVVEQLRSGGVLEAVRVARAGFPVRLTHKQFLGRYR 685
MYSc_Myo25 cd14886
class XXV myosin, motor domain; These myosins are MyTH-FERM myosins that play a role in cell ...
105-768 4.71e-106

class XXV myosin, motor domain; These myosins are MyTH-FERM myosins that play a role in cell adhesion and filopodia formation. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276851  Cd Length: 650  Bit Score: 354.58  E-value: 4.71e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   105 LKERYAAWMIYTYSGLFCVTVNPYKWLP-VYNAEVVAAYRGKKRS-----EAPPHIFSISDNAYQYMLTDRENQSILITG 178
Cdd:cd14886    7 LRDRFAKDKIYTYAGKLLVALNPFKQIRnLYGTEVIGRYRQADTSrgfpsDLPPHSYAVAQSALNGLISDGISQSCIVSG 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   179 ESGAGKTVNTKRVIQYFASiaaigdrskkeNPNANKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGK 258
Cdd:cd14886   87 ESGAGKTETAKQLMNFFAY-----------GHSTSSTDVQSLILGSNPLLESFGNAKTLRNNNSSRFGKFIKLLVGPDGG 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   259 LASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLDMLLVTNNPYdYAFVSQGEVSVA-SIDDSEELLATDSAF 337
Cdd:cd14886  156 LKGGKITSYMLELSRIEFQSTNERNYHIFYQCIKGLSPEEKKSLGFKSLES-YNFLNASKCYDApGIDDQKEFAPVRSQL 234
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   338 DVLsFTAEEKAGVYKLTGAIMHYGNMKFKQKQR---EEQAEPDGTEDADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTK 414
Cdd:cd14886  235 EKL-FSKNEIDSFYKCISGILLAGNIEFSEEGDmgvINAAKISNDEDFGKMCELLGIESSKAAQAIITKVVVINNETIIS 313
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   415 GQSVQQVYYSIGALAKSVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHM 494
Cdd:cd14886  314 PVTQAQAEVNIRAVAKDLYGALFELCVDTLNEIIQFDADARPWIGILDIYGFEFFERNTYEQLLINYANERLQQYFINQV 393
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   495 FVLEQEEYKKEGIEWEFIDFgMDLQACIDLIEKP-MGIMSILEEECMFPKASDMTFKAKLyDNHLgKSNNFQKPrnvKGK 573
Cdd:cd14886  394 FKSEIQEYEIEGIDHSMITF-TDNSNVLAVFDKPnLSIFSFLEEQCLIQTGSSEKFTSSC-KSKI-KNNSFIPG---KGS 467
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   574 QeAHFSLVHYAGTVDYNIMGWLEKNKDPLNETVVGLYQKSSLKLMATLFSTyASADTGDSGKgkggkkkgssfQTVSALH 653
Cdd:cd14886  468 Q-CNFTIVHTAATVTYNTEEFVDKNKHKLSVDILELLMGSTNPIVNKAFSD-IPNEDGNMKG-----------KFLGSTF 534
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   654 RENLNKLMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRIL---NPA 730
Cdd:cd14886  535 QLSIDQLMKTLSATKSHFIRCIKTNQDKVPNKYETKSVYNQLISLSIFESIQTIHRGFAYNDTFEEFFHRNKILishNSS 614
                        650       660       670
                 ....*....|....*....|....*....|....*...
gi 6754774   731 AIPEGQfiDSRKGAEKLLGSLDIDHNQYKFGHTKVFFK 768
Cdd:cd14886  615 SQNAGE--DLVEAVKSILENLGIPCSDYRIGKTKVFLR 650
MYSc_Myo13 cd14875
class XIII myosin, motor domain; These myosins have an N-terminal motor domain, a light-chain ...
101-768 5.08e-105

class XIII myosin, motor domain; These myosins have an N-terminal motor domain, a light-chain binding domain, and a C-terminal GPA/Q-rich domain. There is little known about the function of this myosin class. Two of the earliest members identified in this class are green alga Acetabularia cliftonii, Aclmyo1 and Aclmyo2. They are striking with their short tail of Aclmyo1 of 18 residues and the maximum of 7 IQ motifs in Aclmyo2. It is thought that these myosins are involved in organelle transport and tip growth. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276842 [Multi-domain]  Cd Length: 664  Bit Score: 352.19  E-value: 5.08e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   101 VLYNLKERYAAWMI-YTYSGLFCVTVNPYKWLPvYNAEVvaaYRGKKRSEA-----PPHIFSISDNAY-QYMLTDRENQS 173
Cdd:cd14875    3 LLHCIKERFEKLHQqYSLMGEMVLSVNPFRLMP-FNSEE---ERKKYLALPdprllPPHIWQVAHKAFnAIFVQGLGNQS 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   174 ILITGESGAGKTVNTKRVIQYfasiaaIGDRSKKENPNANKGTLEDQIIQ----ANPALEAFGNAKTVRNDNSSRFGKFI 249
Cdd:cd14875   79 VVISGESGSGKTENAKMLIAY------LGQLSYMHSSNTSQRSIADKIDEnlkwSNPVMESFGNARTVRNDNSSRFGKYI 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   250 RIHF-GATGKLASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLDMLLVTNNPYDY-------AFVSQGeVSV 321
Cdd:cd14875  153 KLYFdPTSGVMVGGQTVTYLLEKSRIIMQSPGERNYHIFYEMLAGLSPEEKKELGGLKTAQDYkclnggnTFVRRG-VDG 231
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   322 ASIDDSEELLATDSAFDVLSFTAEEKAGVYKLTGAIMHYGNMKFKQKQREEQAEPDGTEDAdKSAYLMGLNSADLLKGLC 401
Cdd:cd14875  232 KTLDDAHEFQNVRHALSMIGVELETQNSIFRVLASILHLMEVEFESDQNDKAQIADETPFL-TACRLLQLDPAKLRECFL 310
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   402 hprVKVGNEYVTKGQSVQQVYYSIGALAKSVYEKMFNWMVTRINATLetkQPRQ-----YFIGVLDIAGFEIFDFNSFEQ 476
Cdd:cd14875  311 ---VKSKTSLVTILANKTEAEGFRNAFCKAIYVGLFDRLVEFVNASI---TPQGdcsgcKYIGLLDIFGFENFTRNSFEQ 384
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   477 LCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGmDLQACIDLIE-KPMGIMSILEEECMFPKASDMTFKAKLYD 555
Cdd:cd14875  385 LCINYANESLQNHYNKYTFINDEEECRREGIQIPKIEFP-DNSECVNMFDqKRTGIFSMLDEECNFKGGTTERFTTNLWD 463
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   556 NHLGKSNNFQKPRNVKGKQeahFSLVHYAGTVDYNIMGWLEKNKDPLNETVVGLYQKSSLKLMATLFSTYASADtgdsgk 635
Cdd:cd14875  464 QWANKSPYFVLPKSTIPNQ---FGVNHYAAFVNYNTDEWLEKNTDALKEDMYECVSNSTDEFIRTLLSTEKGLA------ 534
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   636 gkggkkkgSSFQTVSALHRENLNKLMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRI 715
Cdd:cd14875  535 --------RRKQTVAIRFQRQLTDLRTELESTETQFIRCIKPNMEASPSFLDNLLVGSQLESAGVLQTIALKRQGYPVRR 606
                        650       660       670       680       690
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 6754774   716 LYGDF-RQRYRILNPAAIPEGQFIDSRKGAEKLLGSLDIDHN----QYKFGHTKVFFK 768
Cdd:cd14875  607 PIEQFcRYFYLIMPRSTASLFKQEKYSEAAKDFLAYYQRLYGwakpNYAVGKTKVFLR 664
MYSc_Myo18 cd01386
class XVIII myosin, motor domain; Many members of this class contain a N-terminal PDZ domain ...
101-768 7.49e-104

class XVIII myosin, motor domain; Many members of this class contain a N-terminal PDZ domain which is commonly found in proteins establishing molecular complexes. The motor domain itself does not exhibit ATPase activity, suggesting that it functions as an actin tether protein. It also has two IQ domains that probably bind light chains or related calmodulins and a C-terminal tail with two sections of coiled-coil domains, which are thought to mediate homodimerization. The function of these myosins are largely unknown. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276837 [Multi-domain]  Cd Length: 689  Bit Score: 349.69  E-value: 7.49e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   101 VLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGES 180
Cdd:cd01386    3 VLHTLRQRYGANLIHTYAGPSLIVINPRHPLAVYSEKVAKMFKGCRREDMPPHIYASAQSAYRAMLMSRRDQSIVLLGRS 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   181 GAGKTVNTKRVIQYFASIA-AIGDRSKKENPNAnkgtledqiiqANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKL 259
Cdd:cd01386   83 GSGKTTNCRHILEYLVTAAgSVGGVLSVEKLNA-----------ALTVLEAFGNVRTALNGNATRFSQLFSLDFDQAGQL 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   260 ASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLDMLLVTNNPYDYAFvsqGEVSVASIDD----SEELLATDS 335
Cdd:cd01386  152 ASASIQTLLLERSRVARRPEGESNFNVFYYLLAGADAALRTELHLNQLAESNSF---GIVPLQKPEDkqkaAAAFSKLQA 228
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   336 AFDVLSFTAEEKAGVYKLTGAIMHYGN---MKFKQKQREEQAEPdgtEDADKSAYLMGLNSADLLKGLCHPRVKVGNEYV 412
Cdd:cd01386  229 AMKTLGISEEEQRAIWSILAAIYHLGAagaTKAASAGRKQFARP---EWAQRAAYLLGCTLEELSSAIFKHHLSGGPQQS 305
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   413 T---------------KGQSVQQvyySIGALAKSVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFN----- 472
Cdd:cd01386  306 TtssgqesparsssggPKLTGVE---ALEGFAAGLYSELFAAVVSLINRSLSSSHHSTSSITIVDTPGFQNPAHSgsqrg 382
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   473 -SFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLQACIDLIEK---------------PMGIMSILE 536
Cdd:cd01386  383 aTFEDLCHNYAQERLQLLFHERTFVAPLERYKQENVEVDFDLPELSPGALVALIDQapqqalvrsdlrdedRRGLLWLLD 462
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   537 EECMFPKASDMTFKAKLYdNHLGKSNNFQKPRNV-KGKQEAHFSLVHYAGT--VDYNIMGWLEKNK-DPLNETVVGLYQK 612
Cdd:cd01386  463 EEALYPGSSDDTFLERLF-SHYGDKEGGKGHSLLrRSEGPLQFVLGHLLGTnpVEYDVSGWLKAAKeNPSAQNATQLLQE 541
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   613 SSlKLMATLFSTYASADtgdsgkgkggkkkgSSFQtvsalhrenLNKLMTNLKTTHPHFVRCIIPN------ERKAPGV- 685
Cdd:cd01386  542 SQ-KETAAVKRKSPCLQ--------------IKFQ---------VDALIDTLRRTGLHFVHCLLPQhnagkdERSTSSPa 597
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   686 -----MDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPA----AIPEGQFIDSRKGAEKLLGSLDIDHN 756
Cdd:cd01386  598 agdelLDVPLLRSQLRGSQLLDALRLYRQGFPDHMPLGEFRRRFQVLAPPltkkLGLNSEVADERKAVEELLEELDLEKS 677
                        730
                 ....*....|..
gi 6754774   757 QYKFGHTKVFFK 768
Cdd:cd01386  678 SYRIGLSQVFFR 689
MYSc_Myo37 cd14898
class XXXVII myosin, motor domain; The class XXXVIII myosins are comprised of fungi. Not much ...
100-743 2.09e-94

class XXXVII myosin, motor domain; The class XXXVIII myosins are comprised of fungi. Not much is known about this myosin class. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276863  Cd Length: 578  Bit Score: 318.38  E-value: 2.09e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   100 AVLYNLKERYAAWMIYTYSGLFCVTVNPYKwlPVYNAEVVAAYRgKKRSEAPPHIFSISDNAYQYMLTdRENQSILITGE 179
Cdd:cd14898    2 ATLEILEKRYASGKIYTKSGLVFLALNPYE--TIYGAGAMKAYL-KNYSHVEPHVYDVAEASVQDLLV-HGNQTIVISGE 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   180 SGAGKTVNTKRVIQYFASiaaigdrskkenPNANKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFgaTGKL 259
Cdd:cd14898   78 SGSGKTENAKLVIKYLVE------------RTASTTSIEKLITAANLILEAFGNAKTQLNDNSSRFGKRIKLKF--DGKI 143
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   260 ASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKpelldmLLVTNNPYDYAFVSQGEVSVasIDDSEELLATDSAFDV 339
Cdd:cd14898  144 TGAKFETYLLEKSRVTHHEKGERNFHIFYQFCASKR------LNIKNDFIDTSSTAGNKESI--VQLSEKYKMTCSAMKS 215
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   340 LSFTAEEKagVYKLTGAIMHYGNMKFKQkqrEEQAEPDGTEDADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQSVQ 419
Cdd:cd14898  216 LGIANFKS--IEDCLLGILYLGSIQFVN---DGILKLQRNESFTEFCKLHNIQEEDFEESLVKFSIQVKGETIEVFNTLK 290
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   420 QVYYSIGALAKSVYEKMFNWMVTRINATLETKQPRQyfIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQ 499
Cdd:cd14898  291 QARTIRNSMARLLYSNVFNYITASINNCLEGSGERS--ISVLDIFGFEIFESNGLDQLCINWTNEKIQNDFIKKMFRAKQ 368
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   500 EEYKKEGIEWEFIDFgMDLQACIDLIEKPMGIMSILEEECMFP--KASDMTFKAKLYDNHlgksnnfqkprNVKGKQEAH 577
Cdd:cd14898  369 GMYKEEGIEWPDVEF-FDNNQCIRDFEKPCGLMDLISEESFNAwgNVKNLLVKIKKYLNG-----------FINTKARDK 436
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   578 FSLVHYAGTVDYNIMGWLEKNKdplnetvvglyQKSSLKlmatLFSTYASADTGDSgkgkggkkkgssfQTVSALHRENL 657
Cdd:cd14898  437 IKVSHYAGDVEYDLRDFLDKNR-----------EKGQLL----IFKNLLINDEGSK-------------EDLVKYFKDSM 488
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   658 NKLMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIpegQF 737
Cdd:cd14898  489 NKLLNSINETQAKYIKCIRPNEECRPWCFDRDLVSKQLAECGILETIRLSKQCFPQEIPKDRFEERYRILGITLF---EV 565

                 ....*.
gi 6754774   738 IDSRKG 743
Cdd:cd14898  566 VDYRKG 571
MYSc_Myo16 cd14878
class XVI myosin, motor domain; These XVI type myosins are also known as Neuronal ...
100-727 1.92e-93

class XVI myosin, motor domain; These XVI type myosins are also known as Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 3/NYAP3. Myo16 is thought to play a regulatory role in cell cycle progression and has been recently implicated in Schizophrenia. Class XVI myosins are characterized by an N-terminal ankyrin repeat domain and some with chitin synthase domains that arose independently from the ones in the class XVII fungal myosins. They bind protein phosphatase 1 catalytic subunits 1alpha/PPP1CA and 1gamma/PPP1CC. Human Myo16 interacts with ACOT9, ARHGAP26 and PIK3R2 and with components of the WAVE1 complex, CYFIP1 and NCKAP1. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276844 [Multi-domain]  Cd Length: 656  Bit Score: 318.30  E-value: 1.92e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   100 AVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYR---GKKRSEAPPHIFSISDNAYQYMLTDRENQSILI 176
Cdd:cd14878    2 SLLYEIQKRFGNNQIYTFIGDILLLVNPYKELPIYSTMVSQLYLsssGQLCSSLPPHLFSCAERAFHQLFQERRPQCFIL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   177 TGESGAGKTVNTKRVIQYFASIAAigdrskkenpnANKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGAT 256
Cdd:cd14878   82 SGERGSGKTEASKQIMKHLTCRAS-----------SSRTTFDSRFKHVNCILEAFGHAKTTLNDLSSCFIKYFELQFCER 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   257 GK-LASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLDMLLVtNNPYDYAFVSQGE----VSVASIDDSEELL 331
Cdd:cd14878  151 KKhLTGARIYTYMLEKSRLVSQPPGQSNFLIFYLLMDGLSAEEKYGLHL-NNLCAHRYLNQTMredvSTAERSLNREKLA 229
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   332 ATDSAFDVLSFTAEEKAGVYKLTGAIMHYGNMKFKQKQREEQAEPDGTEDADKSAYLMGLNSADLLKGLCHPRVKVGNEY 411
Cdd:cd14878  230 VLKQALNVVGFSSLEVENLFVILSAILHLGDIRFTALTEADSAFVSDLQLLEQVAGMLQVSTDELASALTTDIQYFKGDM 309
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   412 VTKGQSVQQVYYSIGALAKSVYEKMFNWMVTRINATL----ETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQ 487
Cdd:cd14878  310 IIRRHTIQIAEFYRDLLAKSLYSRLFSFLVNTVNCCLqsqdEQKSMQTLDIGILDIFGFEEFQKNEFEQLCVNMTNEKMH 389
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   488 QFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLQACID-LIEKPMGIMSILEEECMFPKASDMTFKAKLyDNHLGKSNNFQK 566
Cdd:cd14878  390 HYINEVLFLQEQTECVQEGVTMETAYSPGNQTGVLDfFFQKPSGFLSLLDEESQMIWSVEPNLPKKL-QSLLESSNTNAV 468
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   567 PRNVKG--------KQEAHFSLVHYAGTVDYNIMGWLEKNKDPLNETVVGLYQKSSLKLMATLFSTyasadtgdsgkgkg 638
Cdd:cd14878  469 YSPMKDgngnvalkDQGTAFTVMHYAGRVMYEIVGAIEKNKDSLSQNLLFVMKTSENVVINHLFQS-------------- 534
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   639 gkkkgsSFQTVSALHRENLNKLMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYG 718
Cdd:cd14878  535 ------KLVTIASQLRKSLADIIGKLQKCTPHFIHCIKPNNSKLPDTFDNFYVSAQLQYIGVLEMVKIFRYGYPVRLSFS 608

                 ....*....
gi 6754774   719 DFRQRYRIL 727
Cdd:cd14878  609 DFLSRYKPL 617
MYSc_Myo26 cd14887
class XXVI myosin, motor domain; These MyTH-FERM myosins are thought to be related to the ...
99-768 1.24e-89

class XXVI myosin, motor domain; These MyTH-FERM myosins are thought to be related to the other myosins that have a MyTH4 domain such as class III, VII, IX, X , XV, XVI, XVII, XX, XXII, XXV, and XXXIV. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276852  Cd Length: 725  Bit Score: 309.27  E-value: 1.24e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    99 PAVLYNLKERYAA--------WMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRE 170
Cdd:cd14887    1 PNLLENLYQRYNKayinkenrNCIYTYTGTLLIAVNPYRFFNLYDRQWISRFDTEANSRLVPHPFGLAEFAYCRLVRDRR 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   171 NQSILITGESGAGKTVNTKRVIQYfasIAAIGDRSKkenpNANKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIR 250
Cdd:cd14887   81 SQSILISGESGAGKTETSKHVLTY---LAAVSDRRH----GADSQGLEARLLQSGPVLEAFGNAHTVLNANSSRFGKMLL 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   251 IHFGATGKLASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKK-PELLDMLLVTNNPYDYafvsqgevsvasiddseE 329
Cdd:cd14887  154 LHFTGRGKLTRASVATYLLANERVVRIPSDEFSFHIFYALCNAAVaAATQKSSAGEGDPEST-----------------D 216
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   330 LLATDSAFDVLSFTAEEKAGVYKLTGAIMHYGNMKFKQKQREEQAEP-----------DGTEDADKSAYLMGLNS----- 393
Cdd:cd14887  217 LRRITAAMKTVGIGGGEQADIFKLLAAILHLGNVEFTTDQEPETSKKrkltsvsvgceETAADRSHSSEVKCLSSglkvt 296
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   394 -------ADLLKGLCHPRVKVGNEYV------------TKGQSVQQVYYSIGALAKSVYEKMFNWMVTRINATLETKQPR 454
Cdd:cd14887  297 easrkhlKTVARLLGLPPGVEGEEMLrlalvsrsvretRSFFDLDGAAAARDAACKNLYSRAFDAVVARINAGLQRSAKP 376
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   455 QY--------------FIGVLDIAGFEIF---DFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFI--DFG 515
Cdd:cd14887  377 SEsdsdedtpsttgtqTIGILDLFGFEDLrnhSKNRLEQLCINYANERLHCFLLEQLILNEHMLYTQEGVFQNQDcsAFP 456
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   516 MDLQACIDLIEKP------------------------MGIMSILEEE-CMFPKASDMTFKAKLYDNHLGK----SNNFQK 566
Cdd:cd14887  457 FSFPLASTLTSSPsstspfsptpsfrsssafatspslPSSLSSLSSSlSSSPPVWEGRDNSDLFYEKLNKniinSAKYKN 536
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   567 PRNVKGKQEAHFSLVHYAGTVDYNIMGWLEKNKDPLNEtvvglyqksSLKLMATLFSTYASADTGDSGKGKGGKKKGSsf 646
Cdd:cd14887  537 ITPALSRENLEFTVSHFACDVTYDARDFCRANREATSD---------ELERLFLACSTYTRLVGSKKNSGVRAISSRR-- 605
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   647 QTVSALHRENLNKLMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRI 726
Cdd:cd14887  606 STLSAQFASQLQQVLKALQETSCHFIRCVKPNRVQEAGIFEDAYVHRQLRCSGMSDLLRVMADGFPCRLPYVELWRRYET 685
                        730       740       750       760
                 ....*....|....*....|....*....|....*....|..
gi 6754774   727 LNPAAIPEgqFIDSRKGAEKLLGSLDIDHNQYKFGHTKVFFK 768
Cdd:cd14887  686 KLPMALRE--ALTPKMFCKIVLMFLEINSNSYTFGKTKIFFR 725
MYSc_Myo24A cd14937
class XXIV A myosin, motor domain; These myosins have a 1-2 IQ motifs in their neck and a ...
101-768 1.98e-86

class XXIV A myosin, motor domain; These myosins have a 1-2 IQ motifs in their neck and a coiled-coil region in their C-terminal tail. The function of the class XXIV myosins remain elusive. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276897  Cd Length: 637  Bit Score: 297.31  E-value: 1.98e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   101 VLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEvvaaYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGES 180
Cdd:cd14937    3 VLNMLALRYKKNYIYTIAEPMLISINPYQVIDVDINE----YKNKNTNELPPHVYSYAKDAMTDFINTKTNQSIIISGES 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   181 GAGKTVNTKRVIQYFASiaaigdRSKKENPNANkgTLEDqiiqANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLA 260
Cdd:cd14937   79 GSGKTEASKLVIKYYLS------GVKEDNEISN--TLWD----SNFILEAFGNAKTLKNNNSSRYGKYIKIELDEYQNIV 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   261 SADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLDMLLVTNNPyDYAFVSQGEVSVASIDDSEELLATDSAFDVL 340
Cdd:cd14937  147 SSSIEIFLLENIRVVSQEEEERGYHIFYQIFNGMSQELKNKYKIRSEN-EYKYIVNKNVVIPEIDDAKDFGNLMISFDKM 225
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   341 SFTAEEKAGVYKLTGAIMhYGNMKFKQ-----KQREEQAEPDGTEDADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKG 415
Cdd:cd14937  226 NMHDMKDDLFLTLSGLLL-LGNVEYQEiekggKTNCSELDKNNLELVNEISNLLGINYENLKDCLVFTEKTIANQKIEIP 304
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   416 QSVQQVYYSIGALAKSVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMF 495
Cdd:cd14937  305 LSVEESVSICKSISKDLYNKIFSYITKRINNFLNNNKELNNYIGILDIFGFEIFSKNSLEQLLINIANEEIHSIYLYIVY 384
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   496 VLEQEEYKKEGIEWEFIDFGMDlQACIDLIEKPMGIMSILEEECMFPKASDMTFkAKLYDNHLGKSNNFQkprNVKGKQE 575
Cdd:cd14937  385 EKETELYKAEDILIESVKYTTN-ESIIDLLRGKTSIISILEDSCLGPVKNDESI-VSVYTNKFSKHEKYA---STKKDIN 459
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   576 AHFSLVHYAGTVDYNIMGWLEKNKDPLNETVVGLYQKSSLKLMATLfstYASADTGDSGKGKggkkkgssfQTVSALHRE 655
Cdd:cd14937  460 KNFVIKHTVSDVTYTITNFISKNKDILPSNIVRLLKVSNNKLVRSL---YEDVEVSESLGRK---------NLITFKYLK 527
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   656 NLNKLMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRIcRKGFPNRILYGDFRQRYRILNPAAIPEG 735
Cdd:cd14937  528 NLNNIISYLKSTNIYFIKCIKPNENKEKNNFNQKKVFPQLFSLSIIETLNI-SFFFQYKYTFDVFLSYFEYLDYSTSKDS 606
                        650       660       670
                 ....*....|....*....|....*....|...
gi 6754774   736 QFIDSRKGAEKLLGSLDIDhnQYKFGHTKVFFK 768
Cdd:cd14937  607 SLTDKEKVSMILQNTVDPD--LYKVGKTMVFLK 637
MYSc_Myo17 cd14879
class XVII myosin, motor domain; This fungal myosin which is also known as chitin synthase ...
105-767 1.37e-85

class XVII myosin, motor domain; This fungal myosin which is also known as chitin synthase uses its motor domain to tether its vesicular cargo to peripheral actin. It works in opposition to dynein, contributing to the retention of Mcs1 vesicles at the site of cell growth and increasing vesicle fusion necessary for polarized growth. Class 17 myosins consist of a N-terminal myosin motor domain with Cyt-b5, chitin synthase 2, and a DEK_C domains at it C-terminus. The chitin synthase region contains several transmembrane domains by which myosin 17 is thought to bind secretory vesicles. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276845 [Multi-domain]  Cd Length: 647  Bit Score: 295.23  E-value: 1.37e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   105 LKERYAAWMIYTY---SGLfcVTVNPYKWLPVYNAEVVAAYR-------GKKRSEAPPHIFSISDNAYQYMLTDRENQSI 174
Cdd:cd14879   10 LASRFRSDLPYTRlgsSAL--VAVNPYKYLSSNSDASLGEYGseyydttSGSKEPLPPHAYDLAARAYLRMRRRSEDQAV 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   175 LITGESGAGKTVNTKRVIQYFASIAAigdRSKKENPnankgtLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFG 254
Cdd:cd14879   88 VFLGETGSGKSESRRLLLRQLLRLSS---HSKKGTK------LSSQISAAEFVLDSFGNAKTLTNPNASRFGRYTELQFN 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   255 ATGKLASADIETYLLEKSRVIfQLKA-ERNYHIFYQILSNKKPELLDmLLVTNNPYDYAFV----SQGEVSVASIDDSE- 328
Cdd:cd14879  159 ERGRLIGAKVLDYRLERSRVA-SVPTgERNFHVFYYLLAGASPEERQ-HLGLDDPSDYALLasygCHPLPLGPGSDDAEg 236
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   329 -ELLATdsAFDVLSFTAEEKAGVYKLTGAIMHYGNMKFKQkqreeqaEPDGTEDA---------DKSAYLMGLNSADLLK 398
Cdd:cd14879  237 fQELKT--ALKTLGFKRKHVAQICQLLAAILHLGNLEFTY-------DHEGGEESavvkntdvlDIVAAFLGVSPEDLET 307
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   399 GLCHPRVKVGNEYVT-----KGQSVQQvyysiGALAKSVYEKMFNWMVTRINATL-ETKQPRQYFIGVLDIAGFEIFD-- 470
Cdd:cd14879  308 SLTYKTKLVRKELCTvfldpEGAAAQR-----DELARTLYSLLFAWVVETINQKLcAPEDDFATFISLLDFPGFQNRSst 382
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   471 -FNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFgMDLQACIDLI-EKPMGIMSILEEEC-MFPKASDM 547
Cdd:cd14879  383 gGNSLDQFCVNFANERLHNYVLRSFFERKAEELEAEGVSVPATSY-FDNSDCVRLLrGKPGGLLGILDDQTrRMPKKTDE 461
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   548 TFKAKLyDNHLGKSNNFQKPRNVKGKQEAH-FSLVHYAGTVDYNIMGWLEKNKDPLNETVVglyqksslklmaTLFSTya 626
Cdd:cd14879  462 QMLEAL-RKRFGNHSSFIAVGNFATRSGSAsFTVNHYAGEVTYSVEGFLERNGDVLSPDFV------------NLLRG-- 526
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   627 sadtgdsgkgkggkkkgssfqtvSALHRENLNKLMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRI 706
Cdd:cd14879  527 -----------------------ATQLNAALSELLDTLDRTRLWSVFCIRPNDSQLPNSFDKRRVKAQIRSLGLPELAAR 583
                        650       660       670       680       690       700
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6754774   707 CRKGFPNRILYGDFRQRYrilnpaaIPEGQFIDSRKGAEKLLGSLDIDHNQYKFGHTKVFF 767
Cdd:cd14879  584 LRVEYVVSLEHAEFCERY-------KSTLRGSAAERIRQCARANGWWEGRDYVLGNTKVFL 637
MYSc_Myo23 cd14884
class XXIII myosin, motor domain; These myosins are predicted to have a neck region with 1-2 ...
99-716 1.74e-73

class XXIII myosin, motor domain; These myosins are predicted to have a neck region with 1-2 IQ motifs and a single MyTH4 domain in its C-terminal tail. The lack of a FERM domain here is odd since MyTH4 domains are usually found alongside FERM domains where they bind to microtubules. At any rate these Class XXIII myosins are still proposed to function in the apicomplexan microtubule cytoskeleton. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276850 [Multi-domain]  Cd Length: 685  Bit Score: 260.61  E-value: 1.74e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    99 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLP-VYNAEVVAAYRGKKRSEA-------PPHIFSISDNAYQYMLTDRE 170
Cdd:cd14884    1 PNVLQNLKNRYLKNKIYTFHASLLLALNPYKPLKeLYDQDVMNVYLHKKSNSAasaapfpKAHIYDIANMAYKNMRGKLK 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   171 NQSILITGESGAGKTVNTKRVIQYFASIAaiGDRSKKEnpnankgtLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIR 250
Cdd:cd14884   81 RQTIVVSGHSGSGKTENCKFLFKYFHYIQ--TDSQMTE--------RIDKLIYINNILESMSNATTIKNNNSSRCGRINL 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   251 IHF---------GATGKLASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLDMLLVTNNPYDYAFV------- 314
Cdd:cd14884  151 LIFeeventqknMFNGCFRNIKIKILLLEINRCIAHNFGERNFHVFYQVLRGLSDEDLARRNLVRNCGVYGLLnpdeshq 230
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   315 ---SQGEVSVAS--IDDSEELLATDSA-----FDVLSFTAEEKAGV---YKLTGAIMHYGNMKFKQkqreeqaepdgted 381
Cdd:cd14884  231 krsVKGTLRLGSdsLDPSEEEKAKDEKnfvalLHGLHYIKYDERQInefFDIIAGILHLGNRAYKA-------------- 296
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   382 adkSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQSVQQVYYSIGALAKSVYEKMFNWMVTRINAT----------LETK 451
Cdd:cd14884  297 ---AAECLQIEEEDLENVIKYKNIRVSHEVIRTERRKENATSTRDTLIKFIYKKLFNKIIEDINRNvlkckekdesDNED 373
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   452 QPR--QYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEW--EFIDFGMDLQACIDLIEK 527
Cdd:cd14884  374 IYSinEAIISILDIYGFEELSGNDFDQLCINLANEKLNNYYINNEIEKEKRIYARENIICcsDVAPSYSDTLIFIAKIFR 453
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   528 PMGIMSILEEECMfpKASDMTFKAKLYDNH----------LGK-SNNFQKPRNVKGK-QEAHFSLVHYAGTVDYNIMGWL 595
Cdd:cd14884  454 RLDDITKLKNQGQ--KKTDDHFFRYLLNNErqqqlegkvsYGFvLNHDADGTAKKQNiKKNIFFIRHYAGLVTYRINNWI 531
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   596 EKNKDPLNETVVGLYQKSSlklMATLFSTYASADTGDsgkgkggkkkgssFQTVSALHRENLNKLMTNLKTTHPHFVRCI 675
Cdd:cd14884  532 DKNSDKIETSIETLISCSS---NRFLREANNGGNKGN-------------FLSVSKKYIKELDNLFTQLQSTDMYYIRCF 595
                        650       660       670       680
                 ....*....|....*....|....*....|....*....|.
gi 6754774   676 IPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRIL 716
Cdd:cd14884  596 LPNAKMLPNTFKRLLVYRQLKQCGSNEMIKILNRGLSHKIP 636
MYSc_Myo12 cd14874
class XXXIII myosin, motor domain; Little is known about the XXXIII class of myosins. They ...
100-736 7.44e-70

class XXXIII myosin, motor domain; Little is known about the XXXIII class of myosins. They are found predominately in nematodes. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276841 [Multi-domain]  Cd Length: 628  Bit Score: 248.25  E-value: 7.44e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   100 AVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYrgkkrseappHIFSISDNAYQYMLTDREN-QSILITG 178
Cdd:cd14874    2 GIAQNLHERFKKGQTYTKASNVLVFVNDFNKLSIQDQLVIKKC----------HISGVAENALDRIKSMSSNaESIVFGG 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   179 ESGAGKTVNTKRVIQYFASiaaigdrskkeNPNANKGTLEDQIIQAnpALEAFGNAKTVRNDNSSRFGKFIRIHFGATGK 258
Cdd:cd14874   72 ESGSGKSYNAFQVFKYLTS-----------QPKSKVTTKHSSAIES--VFKSFGCAKTLKNDEATRFGCSIDLLYKRNVL 138
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   259 LASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLDMLLVTNNpYDYAFVSQGEVSVASIDDSEELLATDSAFD 338
Cdd:cd14874  139 TGLNLKYTVPLEVPRVISQKPGERNFNVFYEVYHGLNDEMKAKFGIKGL-QKFFYINQGNSTENIQSDVNHFKHLEDALH 217
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   339 VLSFTAEEKAGVYKLTGAIMHYGNMKFKQKQR---EEQAEPDGTEDADK-SAYLMGLNSADLLKGLChPRVKVGNEYvtk 414
Cdd:cd14874  218 VLGFSDDHCISIYKIISTILHIGNIYFRTKRNpnvEQDVVEIGNMSEVKwVAFLLEVDFDQLVNFLL-PKSEDGTTI--- 293
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   415 gqSVQQVYYSIGALAKSVYEKMFNWMVTRINatLETKQPRQY-FIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHH 493
Cdd:cd14874  294 --DLNAALDNRDSFAMLIYEELFKWVLNRIG--LHLKCPLHTgVISILDHYGFEKYNNNGVEEFLINSVNERIENLFVKH 369
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   494 MFVLEQEEYKKEGIEwefIDFGMdlQACID-------LIEKPMGIMSILEEECMFPKASDMTFKAKLYDNHLGKSNnFQK 566
Cdd:cd14874  370 SFHDQLVDYAKDGIS---VDYKV--PNSIEngktvelLFKKPYGLLPLLTDECKFPKGSHESYLEHCNLNHTDRSS-YGK 443
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   567 PRNvkgKQEAHFSLVHYAGTVDYNIMGWLEKNKDPLNETVVGLYQKSSLKLMATLFSTYaSADTGDSgkgkggkkkgssF 646
Cdd:cd14874  444 ARN---KERLEFGVRHCIGTTWYNVTDFFSRNKRIISLSAVQLLRSSKNPIIGLLFESY-SSNTSDM------------I 507
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   647 QTVSALHRENLNKLMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRI 726
Cdd:cd14874  508 VSQAQFILRGAQEIADKINGSHAHFVRCIKSNNERQPKKFDIPLVNRQIKNLLLAELLSFRIKGYPVKISKTTFARQYRC 587
                        650
                 ....*....|
gi 6754774   727 LNPAAIPEGQ 736
Cdd:cd14874  588 LLPGDIAMCQ 597
MYSc_Myo20 cd14881
class XX myosin, motor domain; These class 20 myosins are primarily insect myosins with such ...
100-748 8.18e-70

class XX myosin, motor domain; These class 20 myosins are primarily insect myosins with such members as Drosophila, Daphnia, and mosquitoes. These myosins contain a single IQ motif in the neck region. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276847 [Multi-domain]  Cd Length: 633  Bit Score: 248.49  E-value: 8.18e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   100 AVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPvyNAEVVAAYRGKKRSeapPHIFSISDNAYQYMLTDRENQSILITGE 179
Cdd:cd14881    2 AVMKCLQARFYAKEFFTNVGPILLSVNPYRDVG--NPLTLTSTRSSPLA---PQLLKVVQEAVRQQSETGYPQAIILSGT 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   180 SGAGKTVNTKRVIQYFASIAAIGDRSkkenpNANKgtledQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFgATGKL 259
Cdd:cd14881   77 SGSGKTYASMLLLRQLFDVAGGGPET-----DAFK-----HLAAAFTVLRSLGSAKTATNSESSRIGHFIEVQV-TDGAL 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   260 ASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLDML-LVTNNPYDYAFVSQGEVSVASIDDSEELLATDSAFD 338
Cdd:cd14881  146 YRTKIHCYFLDQTRVIRPLPGEKNYHIFYQMLAGLSQEERVKLhLDGYSPANLRYLSHGDTRQNEAEDAARFQAWKACLG 225
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   339 VLS--FTaeekaGVYKLTGAIMHYGNMKFKQKQrEEQAEPDGTEDADKSAYLMGLNSADLLKGL---CHprvkvgneyVT 413
Cdd:cd14881  226 ILGipFL-----DVVRVLAAVLLLGNVQFIDGG-GLEVDVKGETELKSVAALLGVSGAALFRGLttrTH---------NA 290
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   414 KGQ---SVQQVYYSIG---ALAKSVYEKMFNWMVTRIN------ATLETKQpRQYFIGVLDIAGFEIFDFNSFEQLCINF 481
Cdd:cd14881  291 RGQlvkSVCDANMSNMtrdALAKALYCRTVATIVRRANslkrlgSTLGTHA-TDGFIGILDMFGFEDPKPSQLEHLCINL 369
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   482 TNEKLQQFFNHHMFVLEQEEYKKEGIEWEF-IDFgMDLQACIDLIEK-PMGIMSILEEECMfPKASDMTFKAKLYDNHlg 559
Cdd:cd14881  370 CAETMQHFYNTHIFKSSIESCRDEGIQCEVeVDY-VDNVPCIDLISSlRTGLLSMLDVECS-PRGTAESYVAKIKVQH-- 445
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   560 KSNN-FQKPRNVKGKQeahFSLVHYAGTVDYNIMGWLEKNKDPLNETVVGLYQKSSLKLMatlFSTYasadTGDsgkgkg 638
Cdd:cd14881  446 RQNPrLFEAKPQDDRM---FGIRHFAGRVVYDASDFLDTNRDVVPDDLVAVFYKQNCNFG---FATH----TQD------ 509
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   639 gkkkgssFQTvsalhreNLNKLMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYG 718
Cdd:cd14881  510 -------FHT-------RLDNLLRTLVHARPHFVRCIRSNTTETPNHFDRGTVVRQIRSLQVLETVNLMAGGYPHRMRFK 575
                        650       660       670
                 ....*....|....*....|....*....|
gi 6754774   719 DFRQRYRILNPAAiPEGQFIDSRKGAEKLL 748
Cdd:cd14881  576 AFNARYRLLAPFR-LLRRVEEKALEDCALI 604
MYSc_Myo44 cd14905
class XLIV myosin, motor domain; There is little known about the function of the myosin XLIV ...
105-720 9.51e-68

class XLIV myosin, motor domain; There is little known about the function of the myosin XLIV class. Members here include cellular slime mold Polysphondylium and soil-living amoeba Dictyostelium. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276870  Cd Length: 673  Bit Score: 243.46  E-value: 9.51e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   105 LKERYAAWMIYTYSGLFCVTVNPYKWLP-VYNAEVVAAYrgKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGESGAG 183
Cdd:cd14905    7 IQARYKKEIIYTYIGPILVSVNPLRYLPfLHSQELVRNY--NQRRGLPPHLFALAAKAISDMQDFRRDQLIFIGGESGSG 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   184 KTVNTKRVIQYFASIAAigDRSKkenpnankgTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASAD 263
Cdd:cd14905   85 KSENTKIIIQYLLTTDL--SRSK---------YLRDYILESGIILESFGHASTDSNHNSSRWGKYFEMFYSLYGEIQGAK 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   264 IETYLLEKSRVIFQLKAERNYHIFYQILSN-KKPELLDMLLVTNNPYDYaFVSQGEVSVASIDDSEELLATDSAFDVLSF 342
Cdd:cd14905  154 LYSYFLDENRVTYQNKGERNFHIFYQFLKGiTDEEKAAYQLGDINSYHY-LNQGGSISVESIDDNRVFDRLKMSFVFFDF 232
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   343 TAEEKAGVYKLTGAIMHYGNMKFKQKQREeqaepdgTEDADKSaylmglnsadLLKGLCH----PRVKVGNEYVT-KGQS 417
Cdd:cd14905  233 PSEKIDLIFKTLSFIIILGNVTFFQKNGK-------TEVKDRT----------LIESLSHnitfDSTKLENILISdRSMP 295
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   418 VQQVYYSIGALAKSVYEKMFNWMVTRINATLetkQPRQY--FIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMF 495
Cdd:cd14905  296 VNEAVENRDSLARSLYSALFHWIIDFLNSKL---KPTQYshTLGILDLFGQESSQLNGYEQFSINFLEERLQQIYLQTVL 372
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   496 VLEQEEYKKEGIEWEFIDFGMDLQACIDLIEKpmgIMSILEEECMFPKASDMTFKAKLydnhlgksNNFQKPRNVKGKQE 575
Cdd:cd14905  373 KQEQREYQTERIPWMTPISFKDNEESVEMMEK---IINLLDQESKNINSSDQIFLEKL--------QNFLSRHHLFGKKP 441
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   576 AHFSLVHYAGTVDYNIMGWLEKNKDPLNETVVGLYQKSSLKLMAT---LFSTYASADTGDSGKGKGGKKKGSSFQTVSAL 652
Cdd:cd14905  442 NKFGIEHYFGQFYYDVRGFIIKNRDEILQRTNVLHKNSITKYLFSrdgVFNINATVAELNQMFDAKNTAKKSPLSIVKVL 521
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   653 ------HRENLNKLMTN-------------------LKTTHP-------------HFVRCIIPNERKAPGVMDNPLVMHQ 694
Cdd:cd14905  522 lscgsnNPNNVNNPNNNsgggggggnsgggsgsggsTYTTYSstnkainnsncdfHFIRCIKPNSKKTHLTFDVKSVNEQ 601
                        650       660       670
                 ....*....|....*....|....*....|
gi 6754774   695 LRCNGVLEGIRICRKGFP----NRILYGDF 720
Cdd:cd14905  602 IKSLCLLETTRIQRFGYTihynNKIFFDRF 631
MYSc_Myo32 cd14893
class XXXII myosin, motor domain; Class XXXII myosins do not contain any IQ motifs, but ...
102-767 7.32e-63

class XXXII myosin, motor domain; Class XXXII myosins do not contain any IQ motifs, but possess tandem MyTH4 and FERM domains. The myosin classes XXX to XXXIV contain members from Phytophthora species and Hyaloperonospora parasitica. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276858  Cd Length: 741  Bit Score: 230.24  E-value: 7.32e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   102 LYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKR----------SEAPPHIFSISDNAYQYMLTDREN 171
Cdd:cd14893    4 LYTLRARYRMEQVYTWVDRVLVGVNPVTPLPIYTPDHMQAYNKSREqtplyekdtvNDAPPHVFALAQNALRCMQDAGED 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   172 QSILITGESGAGKTVNTKRVIQYFASIA-AIGDRSKKENPNANKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIR 250
Cdd:cd14893   84 QAVILLGGMGAGKSEAAKLIVQYLCEIGdETEPRPDSEGASGVLHPIGQQILHAFTILEAFGNAATRQNRNSSRFAKMIS 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   251 IHFGATGKLASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKK--PELLDMLLVTNNPYDYAFVSQG--EVSVASID- 325
Cdd:cd14893  164 VEFSKHGHVIGGGFTTHYFEKSRVIDCRSHERNFHVFYQVLAGVQhdPTLRDSLEMNKCVNEFVMLKQAdpLATNFALDa 243
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   326 -DSEELLatdSAFDVLSFTAEEKAGVYKLTGAIMHYGNMKFKQKQREEQAEPDGTEDADKSAYLMGLN-------SADLL 397
Cdd:cd14893  244 rDYRDLM---SSFSALRIRKNQRVEIVRIVAALLHLGNVDFVPDPEGGKSVGGANSTTVSDAQSCALKdpaqillAAKLL 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   398 KglCHPRV------------KVGNEYVT--KGQSVQQVYYSIGALAKSVYEKMFNWMVTRINATLETKQPR--------- 454
Cdd:cd14893  321 E--VEPVVldnyfrtrqffsKDGNKTVSslKVVTVHQARKARDTFVRSLYESLFNFLVETLNGILGGIFDRyeksnivin 398
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   455 QYFIGVLDIAGFEIFD--FNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWE-------FIDFGMDLQACIDLI 525
Cdd:cd14893  399 SQGVHVLDMVGFENLTpsQNSFDQLCFNYWSEKVHHFYVQNTLAINFSFLEDESQQVEnrltvnsNVDITSEQEKCLQLF 478
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   526 E-KPMGIMSILEEECMFPKASDMTFKAKLYDNH-----LGKSNNFQKPRNVKGKQEAHFSLV----HYAGTVDYNIMGWL 595
Cdd:cd14893  479 EdKPFGIFDLLTENCKVRLPNDEDFVNKLFSGNeavggLSRPNMGADTTNEYLAPSKDWRLLfivqHHCGKVTYNGKGLS 558
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   596 EKNKDPLNETVVGLYQKSSLKLMATLFSTYASADTGDS--GKGKGGKKKGSSFQTVSALHRENLN--------------K 659
Cdd:cd14893  559 SKNMLSISSTCAAIMQSSKNAVLHAVGAAQMAAASSEKaaKQTEERGSTSSKFRKSASSARESKNitdsaatdvynqadA 638
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   660 LMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRilnpaaipegQFID 739
Cdd:cd14893  639 LLHALNHTGKNFLVCIKPNETLEEGVFDSAYVMKQIRMNHLVELMQASRSIFTVHLTYGHFFRRYK----------NVCG 708
                        730       740       750
                 ....*....|....*....|....*....|..
gi 6754774   740 SRKGAEKLLGSLD----IDHNQYKFGHTKVFF 767
Cdd:cd14893  709 HRGTLESLLRSLSaigvLEEEKFVVGKTKVYL 740
Motor_domain cd01363
Myosin and Kinesin motor domain; Myosin and Kinesin motor domain. These ATPases belong to the ...
121-251 5.82e-61

Myosin and Kinesin motor domain; Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes. Some of the names do not match with what is given in the sequence list. This is because they are based on the current nomenclature by Kollmar/Sebe-Pedros.


Pssm-ID: 276814 [Multi-domain]  Cd Length: 170  Bit Score: 206.43  E-value: 5.82e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   121 FCVTVNPYKWLPVYNAEVV-AAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFASIA 199
Cdd:cd01363    1 VLVRVNPFKELPIYRDSKIiVFYRGFRRSESQPHVFAIADPAYQSMLDGYNNQSIFAYGESGAGKTETMKGVIPYLASVA 80
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 6754774   200 AIGDRSKKEN----PNANKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRI 251
Cdd:cd01363   81 FNGINKGETEgwvyLTEITVTLEDQILQANPILEAFGNAKTTRNENSSRFGKFIEI 136
MYSc_Myo21 cd14882
class XXI myosin, motor domain; The myosins here are comprised of insects. Leishmania class ...
101-727 5.52e-60

class XXI myosin, motor domain; The myosins here are comprised of insects. Leishmania class XXI myosins do not group with them. Myo21, unlike other myosin proteins, contains UBA-like protein domains and has no structural or functional relationship with the myosins present in other organisms possessing cilia or flagella. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. They have diverse tails with IQ, WW, PX, and Tub domains. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276848  Cd Length: 642  Bit Score: 219.61  E-value: 5.52e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   101 VLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGES 180
Cdd:cd14882    3 ILEELRHRYLMGESYTFIGDILLSLNPNEIKQEYPQEFHAKYRCKSRSDNAPHIFSVADSAYQDMLHHEEPQHIILSGES 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   181 GAGKTVNTKRVIQYfasIAAIGDrskkenpnANKGTLEdQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLA 260
Cdd:cd14882   83 YSGKTTNARLLIKH---LCYLGD--------GNRGATG-RVESSIKAILALVNAGTPLNADSTRCILQYQLTFGSTGKMS 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   261 SADIETYLLEKSRVIFQLKAERNYHIFYQILS--NKKPELLDMLLVTNNPYDYAFVSQG-------------EVSVASID 325
Cdd:cd14882  151 GAIFWMYQLEKLRVSTTDGNQSNFHIFYYFYDfiEAQNRLKEYNLKAGRNYRYLRIPPEvppsklkyrrddpEGNVERYK 230
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   326 DSEELLAtdsafdVLSFTAEEKAGVYKLTGAIMHYGNMKFKQKQREeqAEPDGTEDADKSAYLMGLNSADLLKGLCHPRV 405
Cdd:cd14882  231 EFEEILK------DLDFNEEQLETVRKVLAAILNLGEIRFRQNGGY--AELENTEIASRVAELLRLDEKKFMWALTNYCL 302
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   406 KVGNEYVTKGQSVQQVYYSIGALAKSVYEKMFNWMVTRINATLETkqPR-----QYFIGVLDIAGFEIFDFNSFEQLCIN 480
Cdd:cd14882  303 IKGGSAERRKHTTEEARDARDVLASTLYSRLVDWIINRINMKMSF--PRavfgdKYSISIHDMFGFECFHRNRLEQLMVN 380
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   481 FTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLQACIDLIEKPMGIMSILEEecmfpkAS-DMTFKAKLYDNHLG 559
Cdd:cd14882  381 TLNEQMQYHYNQRIFISEMLEMEEEDIPTINLRFYDNKTAVDQLMTKPDGLFYIIDD------ASrSCQDQNYIMDRIKE 454
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   560 KSNNFQKPRNvkgkqeAH-FSLVHYAGTVDYNIMGWLEKNKDPLNETVVGLYQKSSLKLMATLFSTyasadtgdsgkgkg 638
Cdd:cd14882  455 KHSQFVKKHS------AHeFSVAHYTGRIIYDAREFADKNRDFVPPEMIETMRSSLDESVKLMFTN-------------- 514
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   639 gkKKGSSFQTVSALHR----ENLNKLMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNR 714
Cdd:cd14882  515 --SQVRNMRTLAATFRatslELLKMLSIGANSGGTHFVRCIRSDLEYKPRGFHSEVVRQQMRALAVLDTAKARQKGFSYR 592
                        650
                 ....*....|...
gi 6754774   715 ILYGDFRQRYRIL 727
Cdd:cd14882  593 IPFQEFLRRYQFL 605
MYSc_Myo24B cd14938
class XXIV B myosin, motor domain; These myosins have a 1-2 IQ motifs in their neck and a ...
99-766 2.88e-50

class XXIV B myosin, motor domain; These myosins have a 1-2 IQ motifs in their neck and a coiled-coil region in their C-terminal tail. The functions of these myosins remain elusive. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276898 [Multi-domain]  Cd Length: 713  Bit Score: 191.97  E-value: 2.88e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    99 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSE-APPHIFSISDNAYQYMLTDRENQSILIT 177
Cdd:cd14938    1 PSVLYHLKERFKNNKFYTKMGPLLIFINPKINNNINNEETIEKYKCIDCIEdLSLNEYHVVHNALKNLNELKRNQSIIIS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   178 GESGAGKTVNTKRVIQYFA------------SIAAIGDRSKKENPNANKGTLEDQIIQANPALEAFGNAKTVRNDNSSRF 245
Cdd:cd14938   81 GESGSGKSEIAKNIINFIAyqvkgsrrlptnLNDQEEDNIHNEENTDYQFNMSEMLKHVNVVMEAFGNAKTVKNNNSSRF 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   246 GKFIRIHFgATGKLASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLDMLLVTNNPYdYAFVSQGEVSVASID 325
Cdd:cd14938  161 SKFCTIHI-ENEEIKSFHIKKFLLDKERLINRKANENSFNIFYYIINGSSDKFKKMYFLKNIEN-YSMLNNEKGFEKFSD 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   326 DSEELLATDSAFDVLSFTAEEKAGVYKLTGAIMHYGN-------------MKFKQKQRE----------EQAEPDGTEDA 382
Cdd:cd14938  239 YSGKILELLKSLNYIFDDDKEIDFIFSVLSALLLLGNteivkafrkksllMGKNQCGQNinyetilselENSEDIGLDEN 318
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   383 DKSAYL----MGLNSADLLKGLCHPRVkVGNEYVTKGQSVQQVYYSIGALAKSVYEKMFNWMVTRINATLETKQPRQYF- 457
Cdd:cd14938  319 VKNLLLacklLSFDIETFVKYFTTNYI-FNDSILIKVHNETKIQKKLENFIKTCYEELFNWIIYKINEKCTQLQNININt 397
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   458 --IGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLQACIDLIEKPM--GIMS 533
Cdd:cd14938  398 nyINVLDMAYFENSKDNSLEQLLINTTNEEIIKIKNDCLYKKRVLSYNEDGIFCEYNSENIDNEPLYNLLVGPTegSLFS 477
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   534 ILEEECMfPKASDMTFKAKLYDNHLGKSNNFQKPRNVKGKQEAhFSLVHYAGTVDYNIMGWLEKNKDPLNETVVGLYQKS 613
Cdd:cd14938  478 LLENVST-KTIFDKSNLHSSIIRKFSRNSKYIKKDDITGNKKT-FVITHSCGDIIYNAENFVEKNIDILTNRFIDMVKQS 555
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   614 SLKLMATLFSTYASADTGDSGKGKGGKKKGSSF-----------QTVSALHRENLNKLMTNLKTTHPHFVRCIIPNERKA 682
Cdd:cd14938  556 ENEYMRQFCMFYNYDNSGNIVEEKRRYSIQSALklfkrrydtknQMAVSLLRNNLTELEKLQETTFCHFIVCMKPNESKR 635
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   683 P-GVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPaaipegqfiDSRKGAEKLLGSLDIDHNQYKFG 761
Cdd:cd14938  636 ElCSFDANIVLRQVRNFSIVEASQLKVGYYPHKFTLNEFLSIFDIKNE---------DLKEKVEALIKSYQISNYEWMIG 706

                 ....*
gi 6754774   762 HTKVF 766
Cdd:cd14938  707 NNMIF 711
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
846-1745 2.16e-30

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 131.72  E-value: 2.16e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     846 ETEKEMANMKEEFGRVKDALeksearrKELEEKMVSllqekndlqLQVQAEQdnlndAEercdQLIKNKIQLEAKVKEM- 924
Cdd:TIGR02168  176 ETERKLERTRENLDRLEDIL-------NELERQLKS---------LERQAEK-----AE----RYKELKAELRELELALl 230
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     925 TERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEA 1004
Cdd:TIGR02168  231 VLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRER 310
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1005 HQQALDDLQAEEDKVNTLTKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKK 1084
Cdd:TIGR02168  311 LANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQ 390
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1085 KEFDISQQNSKIEDEQALALQLQKKLKENQARIEELEeeleaertaRAKVEKLRSDLSRELEEISERLEEAGGATSVQIE 1164
Cdd:TIGR02168  391 LELQIASLNNEIERLEARLERLEDRRERLQQEIEELL---------KKLEEAELKELQAELEELEEELEELQEELERLEE 461
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1165 MNKKREAEFQKMRRDLEEATLQHEATAAALrkkhaDSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTsnmeQIIKAK 1244
Cdd:TIGR02168  462 ALEELREELEEAEQALDAAERELAQLQARL-----DSLERLQENLEGFSEGVKALLKNQSGLSGILGVLS----ELISVD 532
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1245 ANLEK-VSRTLEDQANEYRVKLEEAQRSLNDFTTQ----RAKLQTENGELARQLEEKEALISQLTRGKLSYtqqmedLKR 1319
Cdd:TIGR02168  533 EGYEAaIEAALGGRLQAVVVENLNAAKKAIAFLKQnelgRVTFLPLDSIKGTEIQGNDREILKNIEGFLGV------AKD 606
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1320 QLEEEGKAKNALAHALQSSRHDCDL-----LREQYEEEMEAkAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKK 1394
Cdd:TIGR02168  607 LVKFDPKLRKALSYLLGGVLVVDDLdnaleLAKKLRPGYRI-VTLDGDLVRPGGVITGGSAKTNSSILERRREIEELEEK 685
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1395 LAQRLQDAEEAVEAVNAkcssLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQK 1474
Cdd:TIGR02168  686 IEELEEKIAELEKALAE----LRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEA 761
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1475 EARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGeggknvhELEKIRKQLEVEKLELQSALEEAEASLE 1554
Cdd:TIGR02168  762 EIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALD-------ELRAELTLLNEEAANLRERLESLERRIA 834
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1555 HEEGKILRAQLEFNQIKAEIErKLAEKDEEMEQAKRNHLRMVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSQA 1634
Cdd:TIGR02168  835 ATERRLEDLEEQIEELSEDIE-SLAAEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKRSEL 913
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1635 NRIASEAQKHLKNSQAHLKDTQLQLDD-AVHANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRK-------LAEQ 1706
Cdd:TIGR02168  914 RRELEELREKLAQLELRLEGLEVRIDNlQERLSEEYSLTLEEAEALENKIEDDEEEARRRLKRLENKIKelgpvnlAAIE 993
                          890       900       910
                   ....*....|....*....|....*....|....*....
gi 6754774    1707 ELIETSERVQLLHSQNTSLINQKKKMESDLTQLQTEVEE 1745
Cdd:TIGR02168  994 EYEELKERYDFLTAQKEDLTEAKETLEEAIEEIDREARE 1032
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
1175-1929 1.40e-28

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 125.94  E-value: 1.40e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1175 KMRRdlEEATLQHEATAAALrKKHADSVAELGEQIDNLQRVKQKLEKEKsefklELddvtsnmeqiikaKANLEKVSRTL 1254
Cdd:TIGR02168  171 KERR--KETERKLERTRENL-DRLEDILNELERQLKSLERQAEKAERYK-----EL-------------KAELRELELAL 229
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1255 edqaneYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHA 1334
Cdd:TIGR02168  230 ------LVLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQ 303
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1335 LQSSRHDCDLLREQYEEEMEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKK------LAQRLQDAEEAVEA 1408
Cdd:TIGR02168  304 KQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELeaeleeLESRLEELEEQLET 383
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1409 VNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEwkqkyeesqselessqKEARSLSTELFKLKN 1488
Cdd:TIGR02168  384 LRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEE----------------AELKELQAELEELEE 447
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1489 AYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKIRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFN 1568
Cdd:TIGR02168  448 ELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGLSGILGVLSE 527
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1569 QIKAEIERKLAekdeeMEQAKRNHLRM--VDSLQTSLDA-ETRSRNEALRVKKKMEGDLNEMEIQLSQANRIAS------ 1639
Cdd:TIGR02168  528 LISVDEGYEAA-----IEAALGGRLQAvvVENLNAAKKAiAFLKQNELGRVTFLPLDSIKGTEIQGNDREILKNiegflg 602
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1640 ------EAQKHLKNSQAHLKDTQLQLDDAVHANDDLKE---NIAIV------------------ERRNNLL--QAELEEL 1690
Cdd:TIGR02168  603 vakdlvKFDPKLRKALSYLLGGVLVVDDLDNALELAKKlrpGYRIVtldgdlvrpggvitggsaKTNSSILerRREIEEL 682
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1691 RAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEE 1770
Cdd:TIGR02168  683 EEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAE 762
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1771 LKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQialkggkkQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIK 1850
Cdd:TIGR02168  763 IEELEERLEEAEEELAEAEAEIEELEAQIEQLKE--------ELKALREALDELRAELTLLNEEAANLRERLESLERRIA 834
                          730       740       750       760       770       780       790
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6754774    1851 ELTYQTEEDKKNLMRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDI 1929
Cdd:TIGR02168  835 ATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKRSEL 913
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
978-1873 5.49e-28

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 123.63  E-value: 5.49e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     978 KNLTEEMAGldeiIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKSKVKLEQQVddlegslEQEKKVRmDLERAKRKL 1057
Cdd:TIGR02168  158 RAIFEEAAG----ISKYKERRKETERKLERTRENLDRLEDILNELERQLKSLERQA-------EKAERYK-ELKAELREL 225
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1058 EGDLkltqesimdLENDKLQLEEKLKKKEFDISQQNSKIEDEQALALQLQKKLKENQARIEELEEELEAERTARAKVEKL 1137
Cdd:TIGR02168  226 ELAL---------LVLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANE 296
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1138 RSDLSRELEEISERLEEAGG---ATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQR 1214
Cdd:TIGR02168  297 ISRLEQQKQILRERLANLERqleELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEE 376
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1215 VKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEyrVKLEEAQRSLNDFTTQRAKLQTENGELARQLE 1294
Cdd:TIGR02168  377 LEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQE--IEELLKKLEEAELKELQAELEELEEELEELQE 454
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1295 EKEALISQLTRGKLSYTQQMEDLkRQLEEEGKAKNALAHALQSsrhdcdlLREQYEEEMEAKAELQRVLSKANSEVAQWR 1374
Cdd:TIGR02168  455 ELERLEEALEELREELEEAEQAL-DAAERELAQLQARLDSLER-------LQENLEGFSEGVKALLKNQSGLSGILGVLS 526
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1375 TKYETDaiqrtEELEEAKKK-LAQRLQ-----DAEEAVEAVNA-------KCSSLEKTKHR---LQNEIEDLMVDVERSN 1438
Cdd:TIGR02168  527 ELISVD-----EGYEAAIEAaLGGRLQavvveNLNAAKKAIAFlkqnelgRVTFLPLDSIKgteIQGNDREILKNIEGFL 601
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1439 AAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNL-----QEEISD 1513
Cdd:TIGR02168  602 GVAKDLVKFDPKLRKALSYLLGGVLVVDDLDNALELAKKLRPGYRIVTLDGDLVRPGGVITGGSAKTNSsilerRREIEE 681
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1514 LTEQLGEGGKNVHELEKIRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERkLAEKDEEMEQAKRNHL 1593
Cdd:TIGR02168  682 LEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQ-LEERIAQLSKELTELE 760
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1594 RMVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSQANRIASEAQKHLKNSQAHLKDTQLQLDDavhanddLKENI 1673
Cdd:TIGR02168  761 AEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLES-------LERRI 833
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1674 AIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIEtservqlLHSQNTSLINQKKKMESDLTQLQTEVEEAVQECRNA 1753
Cdd:TIGR02168  834 AATERRLEDLEEQIEELSEDIESLAAEIEELEELIEE-------LESELEALLNERASLEEALALLRSELEELSEELREL 906
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1754 EEKAKKAITDAAMMAEELKKEQdtsAHLERMKKNMEQTIKDL--QHRLDEAEQIALK-GGKKQLQKLEARVRELENELEA 1830
Cdd:TIGR02168  907 ESKRSELRRELEELREKLAQLE---LRLEGLEVRIDNLQERLseEYSLTLEEAEALEnKIEDDEEEARRRLKRLENKIKE 983
                          890       900       910       920
                   ....*....|....*....|....*....|....*....|...
gi 6754774    1831 EQKRNAESVKGMRKSERRIKELTYQTEEDKKNLMRLQDLVDKL 1873
Cdd:TIGR02168  984 LGPVNLAAIEEYEELKERYDFLTAQKEDLTEAKETLEEAIEEI 1026
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
835-1454 1.56e-26

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 118.89  E-value: 1.56e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   835 YFKIKPLLKSAETE---KEMANMKEEFGRVKDALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLI 911
Cdd:COG1196  215 YRELKEELKELEAElllLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELL 294
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   912 KNKIQLEAKVKEMTERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEII 991
Cdd:COG1196  295 AELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAEL 374
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   992 AKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDL 1071
Cdd:COG1196  375 AEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAEL 454
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1072 ENDKLQLEEKLKKKEFDISQQNSKIEDEQALALQLQKKLKENQARIEELEEELEAERTARAK---------VEKLRSDLS 1142
Cdd:COG1196  455 EEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLaglrglagaVAVLIGVEA 534
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1143 RELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKE 1222
Cdd:COG1196  535 AYEAALEAALAAALQNIVVEDDEVAAAAIEYLKAAKAGRATFLPLDKIRARAALAAALARGAIGAAVDLVASDLREADAR 614
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1223 KSEFKLELDDVTSnmeqiikAKANLEKVSRTLEDQANEYRVKLEEAQRSLndftTQRAKLQTENGELARQLEEKEALISQ 1302
Cdd:COG1196  615 YYVLGDTLLGRTL-------VAARLEAALRRAVTLAGRLREVTLEGEGGS----AGGSLTGGSRRELLAALLEAEAELEE 683
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1303 LTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSSRHDCDLLREQYEEEMEAKAELQRVLSKANSEVAqwrtKYETDAI 1382
Cdd:COG1196  684 LAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEA----LEELPEP 759
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1383 QRTEELEEAKKKLAQRLQD-------AEEAVEAVNAKCSSLEKTKHRLQNEIEDLM-----VDVERSNAAAAALDKKQRN 1450
Cdd:COG1196  760 PDLEELERELERLEREIEAlgpvnllAIEEYEELEERYDFLSEQREDLEEARETLEeaieeIDRETRERFLETFDAVNEN 839

                 ....
gi 6754774  1451 FDKI 1454
Cdd:COG1196  840 FQEL 843
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
842-1610 1.03e-25

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 116.31  E-value: 1.03e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     842 LKSAETEKEMANMKEEFGRVKDALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKIQLEAKV 921
Cdd:TIGR02168  218 LKAELRELELALLVLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEI 297
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     922 KEMTERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKAL 1001
Cdd:TIGR02168  298 SRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEEL 377
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1002 QEAHQQALDDLQAEEDKVNTLTKSKVKLEQQVDDLEGSLEQEKKVRMDLEraKRKLEGDLKLTQESIMDLENDKLQLEEK 1081
Cdd:TIGR02168  378 EEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELL--KKLEEAELKELQAELEELEEELEELQEE 455
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1082 LKKKEFDISQQNSKIEDEQALALQLQKKLKENQARIEELEEELEAERT---ARAKVEKLRSDLSRELEEISER------- 1151
Cdd:TIGR02168  456 LERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGfseGVKALLKNQSGLSGILGVLSELisvdegy 535
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1152 ---LEEAGGATSVQIEMNKKREAefqkmrRDLEEATLQHEATAAAL----RKKHADSVAELGEQIDNLQRVKQ---KLEK 1221
Cdd:TIGR02168  536 eaaIEAALGGRLQAVVVENLNAA------KKAIAFLKQNELGRVTFlpldSIKGTEIQGNDREILKNIEGFLGvakDLVK 609
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1222 EKSEFKLEL----------DDVTSNMEQIIKAKANLEKVSRTLE------------DQAN----EYRVKLEEAQRSLNDF 1275
Cdd:TIGR02168  610 FDPKLRKALsyllggvlvvDDLDNALELAKKLRPGYRIVTLDGDlvrpggvitggsAKTNssilERRREIEELEEKIEEL 689
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1276 TTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSSRHDCDLLREQYEEEMEA 1355
Cdd:TIGR02168  690 EEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEER 769
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1356 KAELQRVLSKANSEVAQWRTKYETDAIQRT------EELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIED 1429
Cdd:TIGR02168  770 LEEAEEELAEAEAEIEELEAQIEQLKEELKalrealDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEE 849
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1430 LMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTEL-------FKLKNAYEESLEHLETFKR 1502
Cdd:TIGR02168  850 LSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELreleskrSELRRELEELREKLAQLEL 929
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1503 ENKNLQEEISDLTEQLGEGGKNVHELekirkqLEVEKLELQSALEEAEASLEHEEGKI-------LRAQLEFNQIKaeiE 1575
Cdd:TIGR02168  930 RLEGLEVRIDNLQERLSEEYSLTLEE------AEALENKIEDDEEEARRRLKRLENKIkelgpvnLAAIEEYEELK---E 1000
                          810       820       830
                   ....*....|....*....|....*....|....*..
gi 6754774    1576 RK--LAEKDEEMEQAKRNHLRMVDslqtSLDAETRSR 1610
Cdd:TIGR02168 1001 RYdfLTAQKEDLTEAKETLEEAIE----EIDREARER 1033
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
1249-1925 1.33e-24

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 112.84  E-value: 1.33e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1249 KVSRTLEDQANEYRVKLEEAQRSLndfttqraKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEeegKAK 1328
Cdd:TIGR02168  145 KISEIIEAKPEERRAIFEEAAGIS--------KYKERRKETERKLERTRENLDRLEDILNELERQLKSLERQAE---KAE 213
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1329 NALAHALQSSRHDCDLLREQYEEEMEAKAELQRVLSKANSEVAQWRTKYETdAIQRTEELEEAKKKLAQRLQDAEEAVEA 1408
Cdd:TIGR02168  214 RYKELKAELRELELALLVLRLEELREELEELQEELKEAEEELEELTAELQE-LEEKLEELRLEVSELEEEIEELQKELYA 292
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1409 VNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKN 1488
Cdd:TIGR02168  293 LANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELES 372
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1489 AYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKIRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLE-- 1566
Cdd:TIGR02168  373 RLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAELKELQAELEELEEELEel 452
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1567 ------FNQIKAEIERKLAEKDEEMEQAKRNH------LRMVDSLQTSLDAETRSRNEALRVKKKMEGDL---------- 1624
Cdd:TIGR02168  453 qeelerLEEALEELREELEEAEQALDAAERELaqlqarLDSLERLQENLEGFSEGVKALLKNQSGLSGILgvlselisvd 532
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1625 NEMEIQLSQA------------NRIASEAQKHLKNSQAH---------LKDTQLQLDDA--------------------- 1662
Cdd:TIGR02168  533 EGYEAAIEAAlggrlqavvvenLNAAKKAIAFLKQNELGrvtflpldsIKGTEIQGNDReilkniegflgvakdlvkfdp 612
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1663 ------------VHANDDLKENIAI----------------------------VERRNNLL--QAELEELRAVVEQTERS 1700
Cdd:TIGR02168  613 klrkalsyllggVLVVDDLDNALELakklrpgyrivtldgdlvrpggvitggsAKTNSSILerRREIEELEEKIEELEEK 692
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1701 RKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQTEVEEAVQECRNAEEK---AKKAITDA----AMMAEELKK 1773
Cdd:TIGR02168  693 IAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERiaqLSKELTELeaeiEELEERLEE 772
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1774 EQDTSAHLERMKKNMEQTIKDLQHRLDEAEQiALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELT 1853
Cdd:TIGR02168  773 AEEELAEAEAEIEELEAQIEQLKEELKALRE-ALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELS 851
                          730       740       750       760       770       780       790
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6754774    1854 YQTEEDKKNLMRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAK 1925
Cdd:TIGR02168  852 EDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREK 923
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
1075-1731 1.33e-22

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 106.17  E-value: 1.33e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1075 KLQLEEKLKKKE---FDISQQNSKIEDEQALALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISER 1151
Cdd:COG1196  217 ELKEELKELEAElllLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAE 296
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1152 LEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALrkkhadsvAELGEQIDNLQRVKQKLEKEKSEFKLELD 1231
Cdd:COG1196  297 LARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEEL--------EELEEELEEAEEELEEAEAELAEAEEALL 368
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1232 DVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTrgklsyt 1311
Cdd:COG1196  369 EAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEE------- 441
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1312 QQMEDLKRQLEEEGKAKNALAHALQSSRHDCDLLREQYEEEMEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEA 1391
Cdd:COG1196  442 EALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRG 521
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1392 KKKLAQRLQDAEEAVEAVnakcsslektkhrLQNEIEDLMVDVERSNAAAAAldkKQRNFDKILAEWKQKYEESQSELES 1471
Cdd:COG1196  522 LAGAVAVLIGVEAAYEAA-------------LEAALAAALQNIVVEDDEVAA---AAIEYLKAAKAGRATFLPLDKIRAR 585
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1472 SQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKnvhelekIRKQLEVEKLELQSALEEAEA 1551
Cdd:COG1196  586 AALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALR-------RAVTLAGRLREVTLEGEGGSA 658
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1552 SLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRMVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQL 1631
Cdd:COG1196  659 GGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELL 738
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1632 SQANRIASEaqkhlknsqahlkdtqlqLDDAVHANDDLKENIAIVERRNNLLQAELEELRAVVEqtersrkLAEQELIET 1711
Cdd:COG1196  739 EELLEEEEL------------------LEEEALEELPEPPDLEELERELERLEREIEALGPVNL-------LAIEEYEEL 793
                        650       660
                 ....*....|....*....|
gi 6754774  1712 SERVQLLHSQNTSLINQKKK 1731
Cdd:COG1196  794 EERYDFLSEQREDLEEARET 813
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
842-1591 3.70e-22

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 104.76  E-value: 3.70e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     842 LKSAETEKEMAnmkEEFGRVKDalEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKIQLEAKV 921
Cdd:TIGR02169  200 LERLRREREKA---ERYQALLK--EKREYEGYELLKEKEALERQKEAIERQLASLEEELEKLTEEISELEKRLEEIEQLL 274
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     922 KEMTERLED--EEEMNA------ELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAK 993
Cdd:TIGR02169  275 EELNKKIKDlgEEEQLRvkekigELEAEIASLERSIAEKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDK 354
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     994 LTKEKKALQEAHQQALDDLQAEEDKVNTLTKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLEN 1073
Cdd:TIGR02169  355 LTEEYAELKEELEDLRAELEEVDKEFAETRDELKDYREKLEKLKREINELKRELDRLQEELQRLSEELADLNAAIAGIEA 434
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1074 DKLQLEEKLKKKEFDISQQNSKIE---------DEQALAL-----QLQKKLKENQARIEELEEELEAERTA----RAKVE 1135
Cdd:TIGR02169  435 KINELEEEKEDKALEIKKQEWKLEqlaadlskyEQELYDLkeeydRVEKELSKLQRELAEAEAQARASEERvrggRAVEE 514
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1136 KLRSDLS------RELEEISER----LEEAGG-----------ATSVQ-IEMNKKREA------EFQKMRRDLEEATLQH 1187
Cdd:TIGR02169  515 VLKASIQgvhgtvAQLGSVGERyataIEVAAGnrlnnvvveddAVAKEaIELLKRRKAgratflPLNKMRDERRDLSILS 594
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1188 EATAAALrkkhADSVAELGEQIDNLQR-------VKQKLEKEKS---EFKL-----ELDDVTSNMEQIIKAKANLEKVSR 1252
Cdd:TIGR02169  595 EDGVIGF----AVDLVEFDPKYEPAFKyvfgdtlVVEDIEAARRlmgKYRMvtlegELFEKSGAMTGGSRAPRGGILFSR 670
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1253 TLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGEL-------ARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEG 1325
Cdd:TIGR02169  671 SEPAELQRLRERLEGLKRELSSLQSELRRIENRLDELsqelsdaSRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLE 750
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1326 KAKNALAHALQSSRHDCDLLREQYEEEMEAKAELQRVLSKanSEVAQWRTKYetdaiqrtEELEEAKKKLAQRLQDAEEA 1405
Cdd:TIGR02169  751 QEIENVKSELKELEARIEELEEDLHKLEEALNDLEARLSH--SRIPEIQAEL--------SKLEEEVSRIEARLREIEQK 820
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1406 VEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFK 1485
Cdd:TIGR02169  821 LNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEELEAALRDLESRLGDLKKERDELEAQLRE 900
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1486 LKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKIR------KQLEVEKLELQSALEEAE-----ASLE 1554
Cdd:TIGR02169  901 LERKIEELEAQIEKKRKRLSELKAKLEALEEELSEIEDPKGEDEEIPeeelslEDVQAELQRVEEEIRALEpvnmlAIQE 980
                          810       820       830
                   ....*....|....*....|....*....|....*...
gi 6754774    1555 HEEGKILRAQLEFNQIKAEIERK-LAEKDEEMEQAKRN 1591
Cdd:TIGR02169  981 YEEVLKRLDELKEKRAKLEEERKaILERIEEYEKKKRE 1018
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
989-1851 1.67e-21

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 102.50  E-value: 1.67e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     989 EIIAKLTKE--KKALQEAHQQaLDDLQAEEDKVNTL-TKSKVKLEQQVDDLEGSLEQ---EKKVRMDLERAKRKLEGDLK 1062
Cdd:pfam15921   66 KIIAYPGKEhiERVLEEYSHQ-VKDLQRRLNESNELhEKQKFYLRQSVIDLQTKLQEmqmERDAMADIRRRESQSQEDLR 144
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1063 ltqesiMDLENDKLQLEEKLKKKEFDISQQNSKIEDEQALALQLQKKLKENQARIEELEEELEAE------------RTA 1130
Cdd:pfam15921  145 ------NQLQNTVHELEAAKCLKEDMLEDSNTQIEQLRKMMLSHEGVLQEIRSILVDFEEASGKKiyehdsmstmhfRSL 218
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1131 RAKVEKLRSDLSRELEEISERLEEAGGA-TSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQI 1209
Cdd:pfam15921  219 GSAISKILRELDTEISYLKGRIFPVEDQlEALKSESQNKIELLLQQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQ 298
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1210 DNLQRVKQKLEKEKSEFKLELDDVTSNMEQIikaKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGEL 1289
Cdd:pfam15921  299 SQLEIIQEQARNQNSMYMRQLSDLESTVSQL---RSELREAKRMYEDKIEELEKQLVLANSELTEARTERDQFSQESGNL 375
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1290 ARQLE---------EKEALISQLTRGKL-----SYTQQMEDLKRQLEEEGKAKNALAHALQSSRHDCdllREQYEEEMEA 1355
Cdd:pfam15921  376 DDQLQklladlhkrEKELSLEKEQNKRLwdrdtGNSITIDHLRRELDDRNMEVQRLEALLKAMKSEC---QGQMERQMAA 452
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1356 KAELQRVLSKANSEVAQWRTKYE---------TDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNE 1426
Cdd:pfam15921  453 IQGKNESLEKVSSLTAQLESTKEmlrkvveelTAKKMTLESSERTVSDLTASLQEKERAIEATNAEITKLRSRVDLKLQE 532
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1427 IEDLMVD---VERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFK-- 1501
Cdd:pfam15921  533 LQHLKNEgdhLRNVQTECEALKLQMAEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEINDRRLELQEFKil 612
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1502 RENKNLQeeisdlteqlgeggknVHELEKIRKQLEVEKLELQSALEE---AEASLEHEEGKILR----AQLEFNQIKAEI 1574
Cdd:pfam15921  613 KDKKDAK----------------IRELEARVSDLELEKVKLVNAGSErlrAVKDIKQERDQLLNevktSRNELNSLSEDY 676
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1575 E---RKLAEKDEEMEQAKrNHLRM-VDSLQTSLDaetRSRNEAlrvkKKMEG-DLNEMEIQLSQANRIASEAQK--HLKN 1647
Cdd:pfam15921  677 EvlkRNFRNKSEEMETTT-NKLKMqLKSAQSELE---QTRNTL----KSMEGsDGHAMKVAMGMQKQITAKRGQidALQS 748
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1648 SQAHLKDTQLQLDDAVH----ANDDLKENIAIVERRNNLLQAELEELRAvvEQTERSRKLAEQELIETSERVQLLHSQNt 1723
Cdd:pfam15921  749 KIQFLEEAMTNANKEKHflkeEKNKLSQELSTVATEKNKMAGELEVLRS--QERRLKEKVANMEVALDKASLQFAECQD- 825
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1724 slINQKKKMESDLTQLQ--TEVEEAVQECRNAEEKAKKAITDAAMMAE---ELKKEQDTSAHL-----------ERMKKN 1787
Cdd:pfam15921  826 --IIQRQEQESVRLKLQhtLDVKELQGPGYTSNSSMKPRLLQPASFTRthsNVPSSQSTASFLshhsrktnalkEDPTRD 903
                          890       900       910       920       930       940       950
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6754774    1788 MEQTIKDLQHRLDEAEQIAL-----KGGKKQLQKLEARVRELENELE-----AEQKRNAESVKGMRKSERRIKE 1851
Cdd:pfam15921  904 LKQLLQELRSVINEEPTVQLskaedKGRAPSLGALDDRVRDCIIESSlrsdiCHSSSNSLQTEGSKSSETCSRE 977
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
845-1580 2.75e-21

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 102.07  E-value: 2.75e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     845 AETEKEMANMKEEFGRVKDALEKSEARRKELEEKMVSLLQEKNDLqLQVQAEQDNLNDAEERcdQLIKNKIQLEAKVKEM 924
Cdd:TIGR02169  166 AEFDRKKEKALEELEEVEENIERLDLIIDEKRQQLERLRREREKA-ERYQALLKEKREYEGY--ELLKEKEALERQKEAI 242
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     925 TERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLEL---------------TLAKVEKEKHATENKVKNLTEEMAGLDE 989
Cdd:TIGR02169  243 ERQLASLEEELEKLTEEISELEKRLEEIEQLLEELNKkikdlgeeeqlrvkeKIGELEAEIASLERSIAEKERELEDAEE 322
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     990 IIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKSKVKLEQQVDDLEGSLEQE-----------KKVRMDLERAKRK-- 1056
Cdd:TIGR02169  323 RLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVdkefaetrdelKDYREKLEKLKREin 402
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1057 -LEGDLKLTQESIMDLENDKLQLEEKLKKKEFDISQQNSKIEDEQALALQLQKKLKENQARIEELEEELEAERTARAKVE 1135
Cdd:TIGR02169  403 eLKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDRVE 482
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1136 KLRSDLSRELEEISERL----EEAGGATSVQIEMNKKREAEFQKMrRDLEEATLQHEA---TAAALRKKHA----DSVAE 1204
Cdd:TIGR02169  483 KELSKLQRELAEAEAQAraseERVRGGRAVEEVLKASIQGVHGTV-AQLGSVGERYATaieVAAGNRLNNVvvedDAVAK 561
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1205 lgEQIDNLQRVK------------QKLEKEKS--------EFKLELDDVTSNMEQIIKAKANLEKVSRTLE---DQANEY 1261
Cdd:TIGR02169  562 --EAIELLKRRKagratflplnkmRDERRDLSilsedgviGFAVDLVEFDPKYEPAFKYVFGDTLVVEDIEaarRLMGKY 639
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1262 R-VKLE--------------EAQRSLNDFTT-QRAKLQTENGELARQLEEKEALISQLTRGK---LSYTQQMEDLKRQLE 1322
Cdd:TIGR02169  640 RmVTLEgelfeksgamtggsRAPRGGILFSRsEPAELQRLRERLEGLKRELSSLQSELRRIEnrlDELSQELSDASRKIG 719
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1323 EEGKAKNALAHALQSSRHDCDLLREQYEEEMEAKAELQRVLSKANSEVAQwrtkYETDAIQRTEELEEAKKKLAQrlqda 1402
Cdd:TIGR02169  720 EIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEARIEE----LEEDLHKLEEALNDLEARLSH----- 790
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1403 eEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTE 1482
Cdd:TIGR02169  791 -SRIPEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELEEE 869
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1483 LFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKIRKQLEVEKLELQSALEEAEASLEHEEgKILR 1562
Cdd:TIGR02169  870 LEELEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKLEALEEELSEIEDPKGEDE-EIPE 948
                          810
                   ....*....|....*...
gi 6754774    1563 AQLEFNQIKAEIERKLAE 1580
Cdd:TIGR02169  949 EELSLEDVQAELQRVEEE 966
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
1108-1911 3.64e-21

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 101.30  E-value: 3.64e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1108 KKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEaggatsVQIEMNKKReaEFQKMRRDLEEAtlqh 1187
Cdd:TIGR02169  156 RKIIDEIAGVAEFDRKKEKALEELEEVEENIERLDLIIDEKRQQLER------LRREREKAE--RYQALLKEKREY---- 223
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1188 EATAAALRKKHADsvaelgEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANL-EKVSRTLEDQANEYRVKLE 1266
Cdd:TIGR02169  224 EGYELLKEKEALE------RQKEAIERQLASLEEELEKLTEEISELEKRLEEIEQLLEELnKKIKDLGEEEQLRVKEKIG 297
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1267 EaqrslndFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSSRHDCDLLR 1346
Cdd:TIGR02169  298 E-------LEAEIASLERSIAEKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLR 370
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1347 EQYEEEMEAKAELQRvlskansEVAQWRTKYEtDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNE 1426
Cdd:TIGR02169  371 AELEEVDKEFAETRD-------ELKDYREKLE-KLKREINELKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEE 442
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1427 IEDLMVDVErsnaaaaALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTElfklknayeesLEHLETFKRENKN 1506
Cdd:TIGR02169  443 KEDKALEIK-------KQEWKLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQRE-----------LAEAEAQARASEE 504
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1507 LQEEISDLTEQLGEGGKNVHELekIRKQLEVEKlELQSALEEA-----------------EASLEHEEGKILRAQ-LEFN 1568
Cdd:TIGR02169  505 RVRGGRAVEEVLKASIQGVHGT--VAQLGSVGE-RYATAIEVAagnrlnnvvveddavakEAIELLKRRKAGRATfLPLN 581
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1569 QIKAE--------------IERKLAEKDEEMEQAKRNHLR---MVDSLQT-----------SLDAE-----------TRS 1609
Cdd:TIGR02169  582 KMRDErrdlsilsedgvigFAVDLVEFDPKYEPAFKYVFGdtlVVEDIEAarrlmgkyrmvTLEGElfeksgamtggSRA 661
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1610 RNEALRVKKKMEGDLNEMEIQLSQANRIASEAQKHLKNSQAHLKDTQLQLDDAVHANDDLKENIAIVERRNNLLQAELEE 1689
Cdd:TIGR02169  662 PRGGILFSRSEPAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEE 741
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1690 LRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLtqLQTEVEEAVQECRNAEEKAKKAITDAAMMAE 1769
Cdd:TIGR02169  742 LEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEEALNDLEARL--SHSRIPEIQAELSKLEEEVSRIEARLREIEQ 819
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1770 ELKKEQDTSAHLERMKKNMEQTIKDLQHRLDE-AEQIALKGGKK-----QLQKLEARVRELENELEAEQKRNAESVKGMR 1843
Cdd:TIGR02169  820 KLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSiEKEIENLNGKKeeleeELEELEAALRDLESRLGDLKKERDELEAQLR 899
                          810       820       830       840       850       860
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6754774    1844 KSERRIKELTYQTEEDKKNLMRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSkFRKVQHELDEAEER 1911
Cdd:TIGR02169  900 ELERKIEELEAQIEKKRKRLSELKAKLEALEEELSEIEDPKGEDEEIPEEELS-LEDVQAELQRVEEE 966
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
1312-1931 3.74e-21

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 101.17  E-value: 3.74e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1312 QQMEDLKRQ---------LEEEGKAKNALAHALQSsrhdcDLLREQYEEEMEAKAELQRVLSKANSEVAQWRTKYEtdai 1382
Cdd:COG1196  200 RQLEPLERQaekaeryreLKEELKELEAELLLLKL-----RELEAELEELEAELEELEAELEELEAELAELEAELE---- 270
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1383 qrteELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKY 1462
Cdd:COG1196  271 ----ELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEEL 346
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1463 EESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKIRKQLEVEKLEL 1542
Cdd:COG1196  347 EEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEEL 426
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1543 QSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRnhlrmvdslqtsLDAETRSRNEALRVKKKMEG 1622
Cdd:COG1196  427 EEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAAL------------LEAALAELLEELAEAAARLL 494
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1623 DLNEMEIQLSQANRIASEAQKHLKNSQAHLKDTQLQLDDAVHAnddlkenIAIVERRNNLLQaeleelRAVVEQTERSRK 1702
Cdd:COG1196  495 LLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYE-------AALEAALAAALQ------NIVVEDDEVAAA 561
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1703 LAEQELIETSERVQLLHSqntSLINQKKKMESDLTQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLE 1782
Cdd:COG1196  562 AIEYLKAAKAGRATFLPL---DKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRR 638
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1783 RMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVkgmRKSERRIKELTYQTEEDKKN 1862
Cdd:COG1196  639 AVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELEL---EEALLAEEEEERELAEAEEE 715
                        570       580       590       600       610       620
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6754774  1863 LMRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSkfrKVQHELDEAEERADIAESQVNKLRAKSRDIGA 1931
Cdd:COG1196  716 RLEEELEEEALEEQLEAEREELLEELLEEEELLE---EEALEELPEPPDLEELERELERLEREIEALGP 781
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
951-1862 5.11e-21

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 100.91  E-value: 5.11e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     951 ELKKDIDDLElTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQAL--DDLQAEEDKV--------- 1019
Cdd:TIGR02169  154 ERRKIIDEIA-GVAEFDRKKEKALEELEEVEENIERLDLIIDEKRQQLERLRREREKAEryQALLKEKREYegyellkek 232
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1020 NTLTKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDL-ENDKLQLEEKLKKKEFDISQQNSKIED 1098
Cdd:TIGR02169  233 EALERQKEAIERQLASLEEELEKLTEEISELEKRLEEIEQLLEELNKKIKDLgEEEQLRVKEKIGELEAEIASLERSIAE 312
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1099 EQALALQLQKKlkenqarieeleeeleaertaRAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRR 1178
Cdd:TIGR02169  313 KERELEDAEER---------------------LAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRA 371
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1179 DLEEAtlqhEATAAALRKKHADSVAEL---GEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVS---- 1251
Cdd:TIGR02169  372 ELEEV----DKEFAETRDELKDYREKLeklKREINELKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKedka 447
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1252 ---RTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLE------ 1322
Cdd:TIGR02169  448 leiKKQEWKLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQRELAEAEAQARASEERVRGGRAVEEVLKASIQgvhgtv 527
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1323 -EEGKAKNALAHALqssrhdcdllreqyeeEMEAKAELQRVLSKaNSEVAQWRTKYETD------------AIQRTEELE 1389
Cdd:TIGR02169  528 aQLGSVGERYATAI----------------EVAAGNRLNNVVVE-DDAVAKEAIELLKRrkagratflplnKMRDERRDL 590
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1390 EAKKK-----LAQRLQDAEEAVEAVNAKC-------SSLEKTKhRLQNEIEDLMVD---VERSNAAAAALDKKQRnfdki 1454
Cdd:TIGR02169  591 SILSEdgvigFAVDLVEFDPKYEPAFKYVfgdtlvvEDIEAAR-RLMGKYRMVTLEgelFEKSGAMTGGSRAPRG----- 664
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1455 laewkqkyeeSQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEK---- 1530
Cdd:TIGR02169  665 ----------GILFSRSEPAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQeeek 734
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1531 ---IRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRMVDslqtsldaET 1607
Cdd:TIGR02169  735 lkeRLEELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEEALNDLEARLSHSRIPEIQAELSKLE--------EE 806
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1608 RSRNEAlrVKKKMEGDLNEmeiqLSQANRIASEAQKHLKNSQahlkdtqlqlddavhanDDLKENIAIVERRNNLLQAEL 1687
Cdd:TIGR02169  807 VSRIEA--RLREIEQKLNR----LTLEKEYLEKEIQELQEQR-----------------IDLKEQIKSIEKEIENLNGKK 863
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1688 EELRAVVEQTERSRKLAEQELIEtservqlLHSQNTSLINQKKKMESDLTQLQTEVEEAvqECRNAEEKAKKAItdaamM 1767
Cdd:TIGR02169  864 EELEEELEELEAALRDLESRLGD-------LKKERDELEAQLRELERKIEELEAQIEKK--RKRLSELKAKLEA-----L 929
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1768 AEELKkeqdtsaHLERMKKNMEQtikdlqhrlDEAEQIALKGGKKQLQKLEARVRELE-------NELEAEQKRNAESVK 1840
Cdd:TIGR02169  930 EEELS-------EIEDPKGEDEE---------IPEEELSLEDVQAELQRVEEEIRALEpvnmlaiQEYEEVLKRLDELKE 993
                          970       980
                   ....*....|....*....|....*
gi 6754774    1841 GMRK--SERR-IKELTYQTEEDKKN 1862
Cdd:TIGR02169  994 KRAKleEERKaILERIEEYEKKKRE 1018
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
1202-1830 8.75e-21

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 100.01  E-value: 8.75e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1202 VAELGEQIDNLQRVKQKLEKEKsEFKLELDdvtsnmeqIIKAKANLEKVsRTLEDQANEYRVKLEEAQRSLNDFTTQRAK 1281
Cdd:COG1196  195 LGELERQLEPLERQAEKAERYR-ELKEELK--------ELEAELLLLKL-RELEAELEELEAELEELEAELEELEAELAE 264
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1282 LQTENGELARQLEEKEalisqltrgklsytqqmEDLKRQLEEEGKAKNALAHALQSSRHDCDLLREQYEEEMEAKAELQR 1361
Cdd:COG1196  265 LEAELEELRLELEELE-----------------LELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAE 327
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1362 VLSKansevaqwrtkyETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAA 1441
Cdd:COG1196  328 LEEE------------LEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAA 395
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1442 AALDKKQRNFDKILAEWKQKyeesqseLESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEG 1521
Cdd:COG1196  396 AELAAQLEELEEAEEALLER-------LERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAEL 468
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1522 GKNVHELEKIRKQLEVEKLELQS---ALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRMVDS 1598
Cdd:COG1196  469 LEEAALLEAALAELLEELAEAAArllLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAAL 548
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1599 LQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSQANRIASEAQKHLKNSQA-HLKDTQLQLDDAVHANDdlkENIAIVE 1677
Cdd:COG1196  549 QNIVVEDDEVAAAAIEYLKAAKAGRATFLPLDKIRARAALAAALARGAIGAAvDLVASDLREADARYYVL---GDTLLGR 625
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1678 RRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQTEVEEAVQECRNAEEKA 1757
Cdd:COG1196  626 TLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEE 705
                        570       580       590       600       610       620       630
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6754774  1758 KKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEA 1830
Cdd:COG1196  706 ERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELERLEREIEA 778
MYSc_Myo33 cd14894
class myosin, motor domain; Class XXXIII myosins have variable numbers of IQ domain and 2 ...
208-708 2.96e-20

class myosin, motor domain; Class XXXIII myosins have variable numbers of IQ domain and 2 tandem ANK repeats that are separated by a PH domain. The myosin classes XXX to XXXIV contain members from Phytophthora species and Hyaloperonospora parasitica. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276859 [Multi-domain]  Cd Length: 871  Bit Score: 98.28  E-value: 2.96e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   208 ENPNANKGTleDQIIQANPALEAFGNAKTVRNDNSSRFGKF--IRIHFGATG---KLASADIETYLLEKSRVIFQL---- 278
Cdd:cd14894  238 KNPHAAKKL--SIVLDSNIVLEAFGHATTSMNLNSSRFGKMttLQVAFGLHPwefQICGCHISPFLLEKSRVTSERgres 315
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   279 --KAERNYHIFYQILSNKKPELLDMLLVTNNPYD------YAFVSQGEVSVASIDDSEELLATD--------SAFDVLSF 342
Cdd:cd14894  316 gdQNELNFHILYAMVAGVNAFPFMRLLAKELHLDgidcsaLTYLGRSDHKLAGFVSKEDTWKKDverwqqviDGLDELNV 395
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   343 TAEEKAGVYKLTGAIMHYGNMKFKQKQREEQAEPDGT---EDADKSAYLMGLNSADLLKGLCHPR---VKVGNEYVTKGQ 416
Cdd:cd14894  396 SPDEQKTIFKVLSAVLWLGNIELDYREVSGKLVMSSTgalNAPQKVVELLELGSVEKLERMLMTKsvsLQSTSETFEVTL 475
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   417 SVQQVYYSIGALAKSVYEKMFNWMV------TRINATLETKQPRQY-----------FIGVLDIAGFEIFDFNSFEQLCI 479
Cdd:cd14894  476 EKGQVNHVRDTLARLLYQLAFNYVVfvmneaTKMSALSTDGNKHQMdsnasapeavsLLKIVDVFGFEDLTHNSLDQLCI 555
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   480 NFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEfidfgmdlQACIDLIEKPMGIMSILEEECMFPKASDMT----------F 549
Cdd:cd14894  556 NYLSEKLYAREEQVIAVAYSSRPHLTARDSE--------KDVLFIYEHPLGVFASLEELTILHQSENMNaqqeekrnklF 627
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   550 KAKLYDNHlgkSNNFQKPRNVKGKQEAH---------FSLVHYAGTVDYNIMGWLEKNKDPLNETV-VGLYQKSSLKL-- 617
Cdd:cd14894  628 VRNIYDRN---SSRLPEPPRVLSNAKRHtpvllnvlpFVIPHTRGNVIYDANDFVKKNSDFVYANLlVGLKTSNSSHFcr 704
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   618 MATLFSTYASADTGDSGKGKGGKKKGSSFQTVSALHRENLNKLMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRC 697
Cdd:cd14894  705 MLNESSQLGWSPNTNRSMLGSAESRLSGTKSFVGQFRSHVNVLTSQDDKNMPFYFHCIRPNAKKQPSLVNNDLVEQQCRS 784
                        570
                 ....*....|.
gi 6754774   698 NGVLEGIRICR 708
Cdd:cd14894  785 QRLIRQMEICR 795
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
919-1795 1.26e-19

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 96.29  E-value: 1.26e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     919 AKVKEMTERLEDEEEMNAELTAKKRKLEDECSELKKdIDDLELTLAKVE-----KEKHATENKVKNLTEEMAGLDEIIAK 993
Cdd:TIGR02169  177 EELEEVEENIERLDLIIDEKRQQLERLRREREKAER-YQALLKEKREYEgyellKEKEALERQKEAIERQLASLEEELEK 255
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     994 LTKEKKALQEAHQQALDDLQAEEDKVNTLTKSK-VKLEQQVDDLEGSLEQekkvrmdlerakrkLEGDLKLTQESIMDLE 1072
Cdd:TIGR02169  256 LTEEISELEKRLEEIEQLLEELNKKIKDLGEEEqLRVKEKIGELEAEIAS--------------LERSIAEKERELEDAE 321
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1073 NDKLQLEEKLKKKEFDISQQNSKIEDEQALALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERL 1152
Cdd:TIGR02169  322 ERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETRDELKDYREKLEKLKREI 401
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1153 EEAggatsvqiemnKKREAEFQKMRRDLEEATLQHEATAAALRKKHAdsvaelgeqidnlqrvkqKLEKEKSEFKLELDD 1232
Cdd:TIGR02169  402 NEL-----------KRELDRLQEELQRLSEELADLNAAIAGIEAKIN------------------ELEEEKEDKALEIKK 452
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1233 VTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEA-------LISQLTR 1305
Cdd:TIGR02169  453 QEWKLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQRELAEAEAQARASEERVRGGRAVEEVLKAsiqgvhgTVAQLGS 532
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1306 GKLSYTQQMEDLKRQ------LEEEGKAKNA--LAHALQSSRHDCDLLReqyeeEMEAKAELQRVLSKANSevaqwrTKY 1377
Cdd:TIGR02169  533 VGERYATAIEVAAGNrlnnvvVEDDAVAKEAieLLKRRKAGRATFLPLN-----KMRDERRDLSILSEDGV------IGF 601
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1378 ETDAIQRTEELEEAkkkLAQRLQDaeeaveavNAKCSSLEKTKhRLQNEIEDLMVD---VERSNAAAAALDKKQRnfdki 1454
Cdd:TIGR02169  602 AVDLVEFDPKYEPA---FKYVFGD--------TLVVEDIEAAR-RLMGKYRMVTLEgelFEKSGAMTGGSRAPRG----- 664
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1455 laewkqkyeeSQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEK---- 1530
Cdd:TIGR02169  665 ----------GILFSRSEPAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQeeek 734
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1531 ---IRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRMVDSLQTSLDAET 1607
Cdd:TIGR02169  735 lkeRLEELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEEALNDLEARLSHSRIPEIQAELSKLEEEVSRIEARL 814
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1608 RSRNEALRvKKKMEGDLNEMEIQLSQANRIASEAQK-----HLKNSQAHLKDTQLQLDDAVHANDDLKENIAIVERRNNL 1682
Cdd:TIGR02169  815 REIEQKLN-RLTLEKEYLEKEIQELQEQRIDLKEQIksiekEIENLNGKKEELEEELEELEAALRDLESRLGDLKKERDE 893
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1683 LQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMES------DLTQLQTEVEEAVQECRNAEEK 1756
Cdd:TIGR02169  894 LEAQLRELERKIEELEAQIEKKRKRLSELKAKLEALEEELSEIEDPKGEDEEipeeelSLEDVQAELQRVEEEIRALEPV 973
                          890       900       910
                   ....*....|....*....|....*....|....*....
gi 6754774    1757 AKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDL 1795
Cdd:TIGR02169  974 NMLAIQEYEEVLKRLDELKEKRAKLEEERKAILERIEEY 1012
PTZ00121 PTZ00121
MAEBL; Provisional
843-1591 1.80e-19

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 96.36  E-value: 1.80e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    843 KSAETEKEMANMKEEFGRVKDALEKSEARRKElEEKMVSLLQEKND---LQLQVQAEQDNLNDAEERCDQLIK------- 912
Cdd:PTZ00121 1118 EEAKKKAEDARKAEEARKAEDARKAEEARKAE-DAKRVEIARKAEDarkAEEARKAEDAKKAEAARKAEEVRKaeelrka 1196
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    913 ---NKIQlEAKVKEMTERLED----EEEMNAELTAK---KRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTE 982
Cdd:PTZ00121 1197 edaRKAE-AARKAEEERKAEEarkaEDAKKAEAVKKaeeAKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAE 1275
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    983 EMAGLDEII----------AKLTKEKKALQEAHQQALDDLQAEEDKVNT------LTKSKVKLEQQVDDLEGSLEQEKKV 1046
Cdd:PTZ00121 1276 EARKADELKkaeekkkadeAKKAEEKKKADEAKKKAEEAKKADEAKKKAeeakkkADAAKKKAEEAKKAAEAAKAEAEAA 1355
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1047 RMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFdisqqNSKIEDEQALALQLQKKLKENQariEELEEELEA 1126
Cdd:PTZ00121 1356 ADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEA-----KKKAEEDKKKADELKKAAAAKK---KADEAKKKA 1427
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1127 ERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEfqKMRRDLEEATLQHEATAAALR-KKHADSVAEL 1205
Cdd:PTZ00121 1428 EEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKAD--EAKKKAEEAKKADEAKKKAEEaKKKADEAKKA 1505
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1206 GEQIDNLQRVKQKLEKEKSEfKLELDDVTSNMEQIIKA--KANLEKVSRTLEDQANEYRVKLEEAQRSlndftTQRAKLQ 1283
Cdd:PTZ00121 1506 AEAKKKADEAKKAEEAKKAD-EAKKAEEAKKADEAKKAeeKKKADELKKAEELKKAEEKKKAEEAKKA-----EEDKNMA 1579
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1284 TENGELARQLEEKEaLISQLTRGKLSYTQQMEDLKRqlEEEGKAKNALAHALQSSRHDCDLLREQYEEEMEAKAELQRVL 1363
Cdd:PTZ00121 1580 LRKAEEAKKAEEAR-IEEVMKLYEEEKKMKAEEAKK--AEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAE 1656
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1364 SKANSEVAQWRTKYETDAiQRTEEL----EEAKKKLAQRLQDAEEA--VEAVNAKCSSLEKTKHRLQNEIEDLMVDVERS 1437
Cdd:PTZ00121 1657 EENKIKAAEEAKKAEEDK-KKAEEAkkaeEDEKKAAEALKKEAEEAkkAEELKKKEAEEKKKAEELKKAEEENKIKAEEA 1735
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1438 naaaaaldKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAY--EESLEHLETFKRENKNLQEEISDLT 1515
Cdd:PTZ00121 1736 --------KKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVieEELDEEDEKRRMEVDKKIKDIFDNF 1807
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1516 EQLGEGGKNVHELEKIRKQLEVEKLE-----LQSALEEAEASLEH------EEGKILRAQLEFNQIKAEIErklaEKDEE 1584
Cdd:PTZ00121 1808 ANIIEGGKEGNLVINDSKEMEDSAIKevadsKNMQLEEADAFEKHkfnknnENGEDGNKEADFNKEKDLKE----DDEEE 1883

                  ....*..
gi 6754774   1585 MEQAKRN 1591
Cdd:PTZ00121 1884 IEEADEI 1890
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
843-1728 7.41e-19

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 93.70  E-value: 7.41e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     843 KSAETEKEMANMKEEFGRVKDALEKS----EARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKIQLE 918
Cdd:pfam01576  353 KHTQALEELTEQLEQAKRNKANLEKAkqalESENAELQAELRTLQQAKQDSEHKRKKLEGQLQELQARLSESERQRAELA 432
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     919 AKVKEMTERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEiiakltkek 998
Cdd:pfam01576  433 EKLSKLQSELESVSSLLNEAEGKNIKLSKDVSSLESQLQDTQELLQEETRQKLNLSTRLRQLEDERNSLQE--------- 503
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     999 kalqeahqqaldDLQAEEDKVNTLTKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEgdlkltqesiMDLENDKLQL 1078
Cdd:pfam01576  504 ------------QLEEEEEAKRNVERQLSTLQAQLSDMKKKLEEDAGTLEALEEGKKRLQ----------RELEALTQQL 561
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1079 EEKLKKKEfdisqqnskiedeqalalqlqkklkenqarieeleeeleaertaraKVEKLRSDLSRELEEISERLEEagga 1158
Cdd:pfam01576  562 EEKAAAYD----------------------------------------------KLEKTKNRLQQELDDLLVDLDH---- 591
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1159 tSVQIEMN-KKREAEFQKMRRDLEEATLQH----EATAAALRKKHADSVAeLGEQIDNLQRVKQKLEKEKSEFKLELDDV 1233
Cdd:pfam01576  592 -QRQLVSNlEKKQKKFDQMLAEEKAISARYaeerDRAEAEAREKETRALS-LARALEEALEAKEELERTNKQLRAEMEDL 669
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1234 TSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNdfTTQRAKLQTEngelarqleekealisqltrgklsytQQ 1313
Cdd:pfam01576  670 VSSKDDVGKNVHELERSKRALEQQVEEMKTQLEELEDELQ--ATEDAKLRLE--------------------------VN 721
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1314 MEDLKRQLEEEGKAKNalahalqssrhdcdllreqyeeemEAKAELQRVLSKansEVAQWRTKYETDAIQRTEELeEAKK 1393
Cdd:pfam01576  722 MQALKAQFERDLQARD------------------------EQGEEKRRQLVK---QVRELEAELEDERKQRAQAV-AAKK 773
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1394 KLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAaaldkkqrnfDKILAEWKQkyeesqselesSQ 1473
Cdd:pfam01576  774 KLELDLKELEAQIDAANKGREEAVKQLKKLQAQMKDLQRELEEARASR----------DEILAQSKE-----------SE 832
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1474 KEARSLSTELFKLKnayeeslEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKIRKQLEVEKLELQSALEEAEASL 1553
Cdd:pfam01576  833 KKLKNLEAELLQLQ-------EDLAASERARRQAQQERDELADEIASGASGKSALQDEKRRLEARIAQLEEELEEEQSNT 905
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1554 EHEEGKILRAQLEFNQIKAEI--ERKLAEKDEEMEQAKRNHLRMVDSLQTSLDAETRSRNEALrvKKKMEGDLNEMEIQL 1631
Cdd:pfam01576  906 ELLNDRLRKSTLQVEQLTTELaaERSTSQKSESARQQLERQNKELKAKLQEMEGTVKSKFKSS--IAALEAKIAQLEEQL 983
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1632 SQANRIASEAQKHLKNSQAHLKDTQLQLDDAVHANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIET 1711
Cdd:pfam01576  984 EQESRERQAANKLVRRTEKKLKEVLLQVEDERRHADQYKDQAEKGNSRMKQLKRQLEEAEEEASRANAARRKLQRELDDA 1063
                          890
                   ....*....|....*..
gi 6754774    1712 SERVQLLHSQNTSLINQ 1728
Cdd:pfam01576 1064 TESNESMNREVSTLKSK 1080
PTZ00121 PTZ00121
MAEBL; Provisional
1214-1936 4.37e-18

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 91.74  E-value: 4.37e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1214 RVKQKLEKEKSEFKLELDDVTSNMEQIIK---AKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTE--NGE 1288
Cdd:PTZ00121 1088 RADEATEEAFGKAEEAKKTETGKAEEARKaeeAKKKAEDARKAEEARKAEDARKAEEARKAEDAKRVEIARKAEDarKAE 1167
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1289 LARQLEEK---EALISQLTRGKLSYTQQMEDLK-----RQLEEEGKAKNALAHALQSSRHDCDLLREQYEEEMEAK-AEL 1359
Cdd:PTZ00121 1168 EARKAEDAkkaEAARKAEEVRKAEELRKAEDARkaeaaRKAEEERKAEEARKAEDAKKAEAVKKAEEAKKDAEEAKkAEE 1247
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1360 QRvlskANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDlmvdversNA 1439
Cdd:PTZ00121 1248 ER----NNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKADEAKKKAEE--------AK 1315
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1440 AAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELfklkNAYEESLEHLETFKRENKNLQEEISDLTEQlg 1519
Cdd:PTZ00121 1316 KADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEA----EAAEEKAEAAEKKKEEAKKKADAAKKKAEE-- 1389
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1520 eggknVHELEKIRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEfnqiKAEIERKLAEKDEEMEQAKRNHLRMVDSL 1599
Cdd:PTZ00121 1390 -----KKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKK----KADEAKKKAEEAKKADEAKKKAEEAKKAE 1460
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1600 QTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSQANRIASEAQKhlkNSQAHLKDTQLQLDDAVHANDDLK---ENIAIV 1676
Cdd:PTZ00121 1461 EAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKK---AAEAKKKADEAKKAEEAKKADEAKkaeEAKKAD 1537
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1677 ERRNNLLQAELEELRAV--VEQTERSRKlAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQTEVEEAVQECRNAE 1754
Cdd:PTZ00121 1538 EAKKAEEKKKADELKKAeeLKKAEEKKK-AEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAE 1616
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1755 EKAKKAitdaammaEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGG--KKQLQKLEARVRELENElEAEQ 1832
Cdd:PTZ00121 1617 EAKIKA--------EELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAeeAKKAEEDKKKAEEAKKA-EEDE 1687
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1833 KRNAESVKGMRKSERRIKELTYQTEEDKKNLMRLQDLVDKLQLKVKAYKRQAEEAE---EQANTNLSKFRKVQHELDEAE 1909
Cdd:PTZ00121 1688 KKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKkkaEEAKKDEEEKKKIAHLKKEEE 1767
                         730       740       750
                  ....*....|....*....|....*....|....*
gi 6754774   1910 ERAD--------IAESQVNKLRAKSRDIGAKKMHD 1936
Cdd:PTZ00121 1768 KKAEeirkekeaVIEEELDEEDEKRRMEVDKKIKD 1802
PTZ00121 PTZ00121
MAEBL; Provisional
832-1513 7.12e-18

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 90.97  E-value: 7.12e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    832 MKLYFKIKPLLKSAETEKEMANMKEEFGRVKDALEKSEARRKELEEKMVSLLQEKNDlQLQVQAEQdnlndAEERCDQLi 911
Cdd:PTZ00121 1262 MAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKADEAKKKAEEAKKAD-EAKKKAEE-----AKKKADAA- 1334
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    912 KNKIQLEAKVKEMTERLEDEEEMNAELTAKKRKL-EDECSELKKDIDDLEltlAKVEKEKHATENKVKnlTEEMAGLDEI 990
Cdd:PTZ00121 1335 KKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAaEKKKEEAKKKADAAK---KKAEEKKKADEAKKK--AEEDKKKADE 1409
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    991 IAKLTKEKKALQEAHQQALDDLQAEEdkvntlTKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGD-LKLTQESIM 1069
Cdd:PTZ00121 1410 LKKAAAAKKKADEAKKKAEEKKKADE------AKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADeAKKKAEEAK 1483
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1070 DLENDKLQLEEKLKKKEfdisqQNSKIEDEQALALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEIS 1149
Cdd:PTZ00121 1484 KADEAKKKAEEAKKKAD-----EAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELK 1558
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1150 ERLEEAggatsvQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEfkle 1229
Cdd:PTZ00121 1559 KAEEKK------KAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKA---- 1628
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1230 lDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRslndfttqRAKLQTENGELARQLEEKEALISQLTRGKLS 1309
Cdd:PTZ00121 1629 -EEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAK--------KAEEDKKKAEEAKKAEEDEKKAAEALKKEAE 1699
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1310 YTQQMEDLKRQLEEEGKAKNALAHALQSSRHDCDLLREQYEEEmEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEEL- 1388
Cdd:PTZ00121 1700 EAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEED-KKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKe 1778
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1389 ----EEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKilAEWKQKYEE 1464
Cdd:PTZ00121 1779 avieEELDEEDEKRRMEVDKKIKDIFDNFANIIEGGKEGNLVINDSKEMEDSAIKEVADSKNMQLEEAD--AFEKHKFNK 1856
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|....*....
gi 6754774   1465 SQSELESSQKEARSlSTELFKLKNAYEESLEHLETFKRENKNLQEEISD 1513
Cdd:PTZ00121 1857 NNENGEDGNKEADF-NKEKDLKEDDEEEIEEADEIEKIDKDDIEREIPN 1904
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
856-1855 2.55e-17

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 89.02  E-value: 2.55e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     856 EEFGRVKDALEKSEARRKELEEKMVSLLQEK-NDLQLQVQAEQDNLNDAEERCDQLIKNKIQLEAKVKEMTERLEDEEE- 933
Cdd:pfam15921  120 QEMQMERDAMADIRRRESQSQEDLRNQLQNTvHELEAAKCLKEDMLEDSNTQIEQLRKMMLSHEGVLQEIRSILVDFEEa 199
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     934 ------------------MNAELTAKKRKLEDECSELKKDIDDLEltlAKVEKEKHATENKVKNLTEEMAG-LDEIIAKL 994
Cdd:pfam15921  200 sgkkiyehdsmstmhfrsLGSAISKILRELDTEISYLKGRIFPVE---DQLEALKSESQNKIELLLQQHQDrIEQLISEH 276
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     995 TKEKKALQE----AHQQAlDDLQAEEDKVNTLTKSKVKL-EQQVDDLEGSLEQekkVRMDLERAKRKLEGDLKLTQESIM 1069
Cdd:pfam15921  277 EVEITGLTEkassARSQA-NSIQSQLEIIQEQARNQNSMyMRQLSDLESTVSQ---LRSELREAKRMYEDKIEELEKQLV 352
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1070 dLENDKLQlEEKLKKKEFdiSQQNSKIEDeqalalQLQKKLkenqarieeleeeleaertarAKVEKLRSDLSRELEEiS 1149
Cdd:pfam15921  353 -LANSELT-EARTERDQF--SQESGNLDD------QLQKLL---------------------ADLHKREKELSLEKEQ-N 400
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1150 ERLEEAGGATSVQIEmnkkreaefqKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKeksefkle 1229
Cdd:pfam15921  401 KRLWDRDTGNSITID----------HLRRELDDRNMEVQRLEALLKAMKSECQGQMERQMAAIQGKNESLEK-------- 462
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1230 lddVTSNMEQIIKAKANLEKVSRTLEDQaneyRVKLEEAQRSLNDFTtqrAKLQtengELARQLEEKEALISQLTRGKLS 1309
Cdd:pfam15921  463 ---VSSLTAQLESTKEMLRKVVEELTAK----KMTLESSERTVSDLT---ASLQ----EKERAIEATNAEITKLRSRVDL 528
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1310 YTQQMEDLKRQLEEEGKAKNAL-AHALQSSRHD--CDLLREQYEEEMEAKAELQRVLSKANSEVAQwrtkYETDAIQRTE 1386
Cdd:pfam15921  529 KLQELQHLKNEGDHLRNVQTECeALKLQMAEKDkvIEILRQQIENMTQLVGQHGRTAGAMQVEKAQ----LEKEINDRRL 604
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1387 ELEEAK----------KKLAQRLQDAE-EAVEAVNAKCSSLEKTKHrLQNEIEDLMVDVERSNaaaAALDKKQRNFDKIL 1455
Cdd:pfam15921  605 ELQEFKilkdkkdakiRELEARVSDLElEKVKLVNAGSERLRAVKD-IKQERDQLLNEVKTSR---NELNSLSEDYEVLK 680
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1456 AEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEE-------------SLEHLETFKRENKN-LQEEISDLTEQLGEG 1521
Cdd:pfam15921  681 RNFRNKSEEMETTTNKLKMQLKSAQSELEQTRNTLKSmegsdghamkvamGMQKQITAKRGQIDaLQSKIQFLEEAMTNA 760
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1522 GKNVHELEKIRKQLEVEKLELQSALEEAEASLEheegkILRAQlefnqikaeiERKLAEKDEEMEQAKRNHlrmvdSLQT 1601
Cdd:pfam15921  761 NKEKHFLKEEKNKLSQELSTVATEKNKMAGELE-----VLRSQ----------ERRLKEKVANMEVALDKA-----SLQF 820
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1602 SLDAETRSRNEALRVKKKMEGDLNEMEIQLSQANRIASEAQKHLKNS---QAHLKDTQLQLDDAVHANDDLKENiAIVER 1678
Cdd:pfam15921  821 AECQDIIQRQEQESVRLKLQHTLDVKELQGPGYTSNSSMKPRLLQPAsftRTHSNVPSSQSTASFLSHHSRKTN-ALKED 899
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1679 RNNLLQAELEELRAVVEQTE-----------------RSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQlqt 1741
Cdd:pfam15921  900 PTRDLKQLLQELRSVINEEPtvqlskaedkgrapslgALDDRVRDCIIESSLRSDICHSSSNSLQTEGSKSSETCSR--- 976
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1742 eveEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDL---------QHR----------LDEA 1802
Cdd:pfam15921  977 ---EPVLLHAGELEDPSSCFTFPSTASPSVKNSASRSFHSSPKKSPVHSLLTSSaegsigsssQYRsaktihspdsVKDS 1053
                         1050      1060      1070      1080      1090
                   ....*....|....*....|....*....|....*....|....*....|...
gi 6754774    1803 EQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQ 1855
Cdd:pfam15921 1054 QSLPIETTGKTCRKLQNRLESLQTLVEDLQLKNQAMSSMIRNQEKRIQKVKDQ 1106
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
861-1427 3.91e-17

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 88.17  E-value: 3.91e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    861 VKDALEKSEARRKELEEKMVSllQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKIQLEAKVKEMTERLEDEEEMNAELTa 940
Cdd:PRK02224  178 VERVLSDQRGSLDQLKAQIEE--KEEKDLHERLNGLESELAELDEEIERYEEQREQARETRDEADEVLEEHEERREELE- 254
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    941 kkrkledecsELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEkKALQEAHQQALDDLQAEedkvn 1020
Cdd:PRK02224  255 ----------TLEAEIEDLRETIAETEREREELAEEVRDLRERLEELEEERDDLLAE-AGLDDADAEAVEARREE----- 318
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1021 tltkskvkLEQQVDDLEGSLEQekkVRMDLERAKRKLEGdlklTQESIMDLENDKLQLEEKLKKKEFDISQQNSKIEDEQ 1100
Cdd:PRK02224  319 --------LEDRDEELRDRLEE---CRVAAQAHNEEAES----LREDADDLEERAEELREEAAELESELEEAREAVEDRR 383
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1101 ALALQLQKKLKENQARIE-------ELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGG--------------AT 1159
Cdd:PRK02224  384 EEIEELEEEIEELRERFGdapvdlgNAEDFLEELREERDELREREAELEATLRTARERVEEAEAlleagkcpecgqpvEG 463
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1160 SVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKkhADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQ 1239
Cdd:PRK02224  464 SPHVETIEEDRERVEELEAELEDLEEEVEEVEERLER--AEDLVEAEDRIERLEERREDLEELIAERRETIEEKRERAEE 541
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1240 IIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELAR------QLEEKEALISQLtRGKLSYTQQ 1313
Cdd:PRK02224  542 LRERAAELEAEAEEKREAAAEAEEEAEEAREEVAELNSKLAELKERIESLERirtllaAIADAEDEIERL-REKREALAE 620
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1314 MEDLKR-QLEEEGKAKNALAHALQSSRhdcdllreqYEEEMEAKAELQRVLSKANSEVAQWRTkyETDAIQRT------- 1385
Cdd:PRK02224  621 LNDERReRLAEKRERKRELEAEFDEAR---------IEEAREDKERAEEYLEQVEEKLDELRE--ERDDLQAEigavene 689
                         570       580       590       600
                  ....*....|....*....|....*....|....*....|...
gi 6754774   1386 -EELEEAKKKLAQrLQDAEEAVEAVNAKCSSLEKTKHRLQNEI 1427
Cdd:PRK02224  690 lEELEELRERREA-LENRVEALEALYDEAEELESMYGDLRAEL 731
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
1204-1933 1.04e-16

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 86.77  E-value: 1.04e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1204 ELGEQIDNLQRVKQKLEKEKSEFKleldDVTSNMEQIIKAKANLEKVSRT---LEDQANEYRVKLEEAQRSLNDFTtqra 1280
Cdd:pfam01576    6 EMQAKEEELQKVKERQQKAESELK----ELEKKHQQLCEEKNALQEQLQAeteLCAEAEEMRARLAARKQELEEIL---- 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1281 klqtenGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKnalaHALQSSRHDCDLLREQYEEEMEAKAELQ 1360
Cdd:pfam01576   78 ------HELESRLEEEEERSQQLQNEKKKMQQHIQDLEEQLDEEEAAR----QKLQLEKVTTEAKIKKLEEDILLLEDQN 147
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1361 RVLSKAnsevaqwrtkyetdaiqrteeleeaKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAA 1440
Cdd:pfam01576  148 SKLSKE-------------------------RKLLEERISEFTSNLAEEEEKAKSLSKLKNKHEAMISDLEERLKKEEKG 202
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1441 AAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGE 1520
Cdd:pfam01576  203 RQELEKAKRKLEGESTDLQEQIAELQAQIAELRAQLAKKEEELQAALARLEEETAQKNNALKKIRELEAQISELQEDLES 282
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1521 GGKNVHELEKIRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRMVDSLQ 1600
Cdd:pfam01576  283 ERAARNKAEKQRRDLGEELEALKTELEDTLDTTAAQQELRSKREQEVTELKKALEEETRSHEAQLQEMRQKHTQALEELT 362
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1601 TSLDAETRSRNEALRVKKKMEGDLNEMEIQLSQANRIASEAQKHLKNSQAHLKDTQLQLDDAVHANDDLKEniaiverRN 1680
Cdd:pfam01576  363 EQLEQAKRNKANLEKAKQALESENAELQAELRTLQQAKQDSEHKRKKLEGQLQELQARLSESERQRAELAE-------KL 435
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1681 NLLQAELEELRAVVEQTE-RSRKLA------EQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQTEVEEAVQECRNA 1753
Cdd:pfam01576  436 SKLQSELESVSSLLNEAEgKNIKLSkdvsslESQLQDTQELLQEETRQKLNLSTRLRQLEDERNSLQEQLEEEEEAKRNV 515
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1754 EEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKggkkqLQKLEARVRELENELEAEQK 1833
Cdd:pfam01576  516 ERQLSTLQAQLSDMKKKLEEDAGTLEALEEGKKRLQRELEALTQQLEEKAAAYDK-----LEKTKNRLQQELDDLLVDLD 590
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1834 RNAESVKGMRKSERRIKELTyqtEEDKKNLMRLQDLVDKlqlkvkaykrqaeeAEEQANTNLSKFRKVQHELDEAEERAD 1913
Cdd:pfam01576  591 HQRQLVSNLEKKQKKFDQML---AEEKAISARYAEERDR--------------AEAEAREKETRALSLARALEEALEAKE 653
                          730       740
                   ....*....|....*....|
gi 6754774    1914 IAESQVNKLRAKSRDIGAKK 1933
Cdd:pfam01576  654 ELERTNKQLRAEMEDLVSSK 673
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
862-1575 2.31e-16

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 85.46  E-value: 2.31e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     862 KDALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLiKNKIQ-LEAKVKEMTERLEDEEEMNAELTA 940
Cdd:TIGR04523   25 KNIANKQDTEEKQLEKKLKTIKNELKNKEKELKNLDKNLNKDEEKINNS-NNKIKiLEQQIKDLNDKLKKNKDKINKLNS 103
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     941 KKRKLEDECSELKKDIDDLELTLAKVEKEKHATE-------NKVKNLTEEMAGLDEIIAKLTKEKKALqeahqqalddlq 1013
Cdd:TIGR04523  104 DLSKINSEIKNDKEQKNKLEVELNKLEKQKKENKknidkflTEIKKKEKELEKLNNKYNDLKKQKEEL------------ 171
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1014 aeEDKVNTLTKSKVKLEQQVDDLEGSLEQEKKVRMDLErakrKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDISQQN 1093
Cdd:TIGR04523  172 --ENELNLLEKEKLNIQKNIDKIKNKLLKLELLLSNLK----KKIQKNKSLESQISELKKQNNQLKDNIEKKQQEINEKT 245
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1094 SKIEDEQALALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEaggatsvqiEMNKKREAEF 1173
Cdd:TIGR04523  246 TEISNTQTQLNQLKDEQNKIKKQLSEKQKELEQNNKKIKELEKQLNQLKSEISDLNNQKEQ---------DWNKELKSEL 316
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1174 QKMRRDLEEATLQheataaalRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRT 1253
Cdd:TIGR04523  317 KNQEKKLEEIQNQ--------ISQNNKIISQLNEQISQLKKELTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEIKN 388
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1254 LEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLtrgklsyTQQMEDLKRQLEEEGKAKNALAH 1333
Cdd:TIGR04523  389 LESQINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIERLKETIIKN-------NSEIKDLTNQDSVKELIIKNLDN 461
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1334 ALQSSRHDCDLLREQYEEEMEAKAELQRVLSKANSEVaqwrtkyetdaiqrtEELEEAKKKLAQRLQDAEEAVEAVNAKC 1413
Cdd:TIGR04523  462 TRESLETQLKVLSRSINKIKQNLEQKQKELKSKEKEL---------------KKLNEEKKELEEKVKDLTKKISSLKEKI 526
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1414 SSLEKTKHRLQNEIEDLMVDVER--SNAAAAALDKKQRNFDKILAEWKQKYEesqselessqkearslstelfKLKNAYE 1491
Cdd:TIGR04523  527 EKLESEKKEKESKISDLEDELNKddFELKKENLEKEIDEKNKEIEELKQTQK---------------------SLKKKQE 585
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1492 ESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKIRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIK 1571
Cdd:TIGR04523  586 EKQELIDQKEKEKKDLIKEIEEKEKKISSLEKELEKAKKENEKLSSIIKNIKSKKNKLKQEVKQIKETIKEIRNKWPEII 665

                   ....
gi 6754774    1572 AEIE 1575
Cdd:TIGR04523  666 KKIK 669
PTZ00121 PTZ00121
MAEBL; Provisional
1011-1805 6.16e-16

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 84.81  E-value: 6.16e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1011 DLQAEEDKVNTLTKS--KVKLEQQVDDLEGSLEQEKKVRMDLERAK--RKLEGDLKLTQ----ESIMDLENDKL-----Q 1077
Cdd:PTZ00121 1080 DFDAKEDNRADEATEeaFGKAEEAKKTETGKAEEARKAEEAKKKAEdaRKAEEARKAEDarkaEEARKAEDAKRveiarK 1159
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1078 LEEKLKKKEFDISQQNSKIED-----EQALALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERL 1152
Cdd:PTZ00121 1160 AEDARKAEEARKAEDAKKAEAarkaeEVRKAEELRKAEDARKAEAARKAEEERKAEEARKAEDAKKAEAVKKAEEAKKDA 1239
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1153 EEAggatsvqiemNKKREAEFQKMRRDLEEATLQHEATAAALRKKHAdsvAELGEQIDNLQRVKQKLEKEKSEFKLELDD 1232
Cdd:PTZ00121 1240 EEA----------KKAEEERNNEEIRKFEEARMAHFARRQAAIKAEE---ARKADELKKAEEKKKADEAKKAEEKKKADE 1306
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1233 VTSNMEQIIKAKaNLEKVSRTLEDQANEYRVKLEEAQRSLN------DFTTQRAKLQTENGELARQLEEKEALISQLTRG 1306
Cdd:PTZ00121 1307 AKKKAEEAKKAD-EAKKKAEEAKKKADAAKKKAEEAKKAAEaakaeaEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKK 1385
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1307 KLSYTQQMEDLKRQLEEEGKAKNALAHALQSSRHDCDLLREQYE----EEMEAKAELQRVLSKANSEVAQWR----TKYE 1378
Cdd:PTZ00121 1386 KAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEkkkaDEAKKKAEEAKKADEAKKKAEEAKkaeeAKKK 1465
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1379 TDAIQRTEEL----------EEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQ 1448
Cdd:PTZ00121 1466 AEEAKKADEAkkkaeeakkaDEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEK 1545
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1449 RNFDKILAEWKQKYEESQSELESSQKEARSLSTELFK---LKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNV 1525
Cdd:PTZ00121 1546 KKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKaeeAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEEL 1625
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1526 HELEKIRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEfnQIKAEIERKLAE---KDEEMEQAKRNHLRMVDSLQTS 1602
Cdd:PTZ00121 1626 KKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEE--AKKAEEDKKKAEeakKAEEDEKKAAEALKKEAEEAKK 1703
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1603 LDAETRSRNEALRVKKKMEGDLNEMEIQLSQANRIASE----AQKHLKNSQAHLKDTQLQLDDAVHANDDLKENIAIVER 1678
Cdd:PTZ00121 1704 AEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEdkkkAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEE 1783
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1679 RnnlLQAELEELRAVVEQTERSRKlaeqeliETSERVQLLHSQNTSLINQKKKMESdltqlqTEVEEAVQECRNAEEKAK 1758
Cdd:PTZ00121 1784 E---LDEEDEKRRMEVDKKIKDIF-------DNFANIIEGGKEGNLVINDSKEMED------SAIKEVADSKNMQLEEAD 1847
                         810       820       830       840
                  ....*....|....*....|....*....|....*....|....*..
gi 6754774   1759 KAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRlDEAEQI 1805
Cdd:PTZ00121 1848 AFEKHKFNKNNENGEDGNKEADFNKEKDLKEDDEEEIEEA-DEIEKI 1893
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
967-1823 2.03e-15

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 82.71  E-value: 2.03e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     967 EKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQAlddlQAEEDKVNTLTKSKVKLEQQVDDLEGSLEQEKKV 1046
Cdd:pfam02463  176 KKLIEETENLAELIIDLEELKLQELKLKEQAKKALEYYQLKE----KLELEEEYLLYLDYLKLNEERIDLLQELLRDEQE 251
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1047 RMDLERAKRKLEGDLKLTQESIMDLEN----------DKLQLEEKLKKKEFDISQQNSKIEDEQALALQ-----LQKKLK 1111
Cdd:pfam02463  252 EIESSKQEIEKEEEKLAQVLKENKEEEkekklqeeelKLLAKEEEELKSELLKLERRKVDDEEKLKESEkekkkAEKELK 331
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1112 ENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEatlqhEATA 1191
Cdd:pfam02463  332 KEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELELKSE-----EEKE 406
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1192 AALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKAN-LEKVSRTLEDQANEYRVKLEEAQR 1270
Cdd:pfam02463  407 AQLLLELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLLkDELELKKSEDLLKETQLVKLQEQL 486
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1271 SLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAhalqssrhdCDLLREQYE 1350
Cdd:pfam02463  487 ELLLSRQKLEERSQKESKARSGLKVLLALIKDGVGGRIISAHGRLGDLGVAVENYKVAISTA---------VIVEVSATA 557
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1351 EEMEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRlqnEIEDL 1430
Cdd:pfam02463  558 DEVEERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAVLEIDPILNLAQLDKATLEADEDDKRAKVVEGIL---KDTEL 634
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1431 MVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSlstELFKLKNAYEESLEHLETFKRENKNLQEE 1510
Cdd:pfam02463  635 TKLKESAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKELLEIQELQ---EKAESELAKEEILRRQLEIKKKEQREKEE 711
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1511 ISDLTEQLGEGGKNVHELEKIRKQLEVEKLELQSA---LEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQ 1587
Cdd:pfam02463  712 LKKLKLEAEELLADRVQEAQDKINEELKLLKQKIDeeeEEEEKSRLKKEEKEEEKSELSLKEKELAEEREKTEKLKVEEE 791
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1588 AKRNHLRMVDSLqtsldaetrsRNEALRVKKKMEGDLNEMEIQLSQANRIASEAQKHLKNSQAHLKDTQLqldDAVHAND 1667
Cdd:pfam02463  792 KEEKLKAQEEEL----------RALEEELKEEAELLEEEQLLIEQEEKIKEEELEELALELKEEQKLEKL---AEEELER 858
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1668 DLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNtSLINQKKKMESDLTQLQTEVEEAV 1747
Cdd:pfam02463  859 LEEEITKEELLQELLLKEEELEEQKLKDELESKEEKEKEEKKELEEESQKLNLLE-EKENEIEERIKEEAEILLKYEEEP 937
                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6754774    1748 QECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNM---EQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRE 1823
Cdd:pfam02463  938 EELLLEEADEKEKEENNKEEEEERNKRLLLAKEELGKVNLMaieEFEEKEERYNKDELEKERLEEEKKKLIRAIIEETC 1016
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
899-1536 2.19e-15

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 82.42  E-value: 2.19e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    899 NLNDAEERCDQLIKNKIQLEAKVKEMTERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELT---LAKVEKEKHATEN 975
Cdd:PRK03918  173 EIKRRIERLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREELEKLEKEVKELEELkeeIEELEKELESLEG 252
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    976 KVKNLTEEMAGLDEIIAKLTKEKKALqeahqqalddlqaeEDKVNTLTKSKVKLEQQVdDLEGSLEQEKKVRMDLERAKR 1055
Cdd:PRK03918  253 SKRKLEEKIRELEERIEELKKEIEEL--------------EEKVKELKELKEKAEEYI-KLSEFYEEYLDELREIEKRLS 317
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1056 KLEGDLKLTQESIMDLENDKLQLEEkLKKKEFDISQQNSKIEdEQALALQLQKKLKENQARIEELEEELEAERTARA--K 1133
Cdd:PRK03918  318 RLEEEINGIEERIKELEEKEERLEE-LKKKLKELEKRLEELE-ERHELYEEAKAKKEELERLKKRLTGLTPEKLEKEleE 395
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1134 VEKLRSDLSRELEEISERLEEAggatsvqiemnKKREAEFQKMRRDLEEATLQHEATAAALRKKH-ADSVAELGEQIDNL 1212
Cdd:PRK03918  396 LEKAKEEIEEEISKITARIGEL-----------KKEIKELKKAIEELKKAKGKCPVCGRELTEEHrKELLEEYTAELKRI 464
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1213 QRVKQKLEKEKSEFK---LELDDVTSNMEQIIKAKANLEKVsRTLEDQANEYRV-KLEEAQRSLNDFTTQRAKLQTENGE 1288
Cdd:PRK03918  465 EKELKEIEEKERKLRkelRELEKVLKKESELIKLKELAEQL-KELEEKLKKYNLeELEKKAEEYEKLKEKLIKLKGEIKS 543
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1289 LARQLEEKEALISQLTrgklsytqQMEDLKRQLEEEGKaknalahalqssrhdcDLLREQYEEEMEAKAELQRvlskans 1368
Cdd:PRK03918  544 LKKELEKLEELKKKLA--------ELEKKLDELEEELA----------------ELLKELEELGFESVEELEE------- 592
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1369 evaqwrtkyetdaiqRTEELEEAKKKLaqrlqdaeeaVEAVNAkcsslEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQ 1448
Cdd:PRK03918  593 ---------------RLKELEPFYNEY----------LELKDA-----EKELEREEKELKKLEEELDKAFEELAETEKRL 642
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1449 RNFDKILAEWKQKYeesqselesSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHEL 1528
Cdd:PRK03918  643 EELRKELEELEKKY---------SEEEYEELREEYLELSRELAGLRAELEELEKRREEIKKTLEKLKEELEEREKAKKEL 713

                  ....*...
gi 6754774   1529 EKIRKQLE 1536
Cdd:PRK03918  714 EKLEKALE 721
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
1610-1925 2.63e-15

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 82.29  E-value: 2.63e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1610 RNEALRVKKKMEGDLN-------EMEIQLSQANRIASEAQKHLKNsQAHLKDTQLQLddAVHANDDLKENIAIVERRNNL 1682
Cdd:COG1196  174 KEEAERKLEATEENLErledilgELERQLEPLERQAEKAERYREL-KEELKELEAEL--LLLKLRELEAELEELEAELEE 250
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1683 LQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQTEVEEAVQECRNAEEKAKKAIT 1762
Cdd:COG1196  251 LEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEE 330
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1763 DAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKgM 1842
Cdd:COG1196  331 ELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEA-E 409
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1843 RKSERRIKELTYQTEEDKKNLMRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKL 1922
Cdd:COG1196  410 EALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEA 489

                 ...
gi 6754774  1923 RAK 1925
Cdd:COG1196  490 AAR 492
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
842-1403 8.17e-15

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 80.55  E-value: 8.17e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     842 LKSAETEKEMANMKEEFGRVKDALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNlndAEERCDQLIKNKIQLEAKV 921
Cdd:pfam15921  250 LKSESQNKIELLLQQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQLEIIQEQ---ARNQNSMYMRQLSDLESTV 326
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     922 kemterledeEEMNAELTAKKRKLEDECSELKKD--IDDLELTLAKVEKEKHATENkvKNLTEEmagLDEIIAKLTKEKK 999
Cdd:pfam15921  327 ----------SQLRSELREAKRMYEDKIEELEKQlvLANSELTEARTERDQFSQES--GNLDDQ---LQKLLADLHKREK 391
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1000 ALQEAHQQ--------------------ALDDLQAEEDKVNTLTKS-----KVKLEQQVDDLEG---SLEQEKKVRMDLE 1051
Cdd:pfam15921  392 ELSLEKEQnkrlwdrdtgnsitidhlrrELDDRNMEVQRLEALLKAmksecQGQMERQMAAIQGkneSLEKVSSLTAQLE 471
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1052 RAKRKLEGDLKLTQESIMDLENDKL---QLEEKLKKKEFDISQQNSKIEDEQA---LALQLQKKLKENQARIEELEEELE 1125
Cdd:pfam15921  472 STKEMLRKVVEELTAKKMTLESSERtvsDLTASLQEKERAIEATNAEITKLRSrvdLKLQELQHLKNEGDHLRNVQTECE 551
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1126 AERTARAKVEKLRSDLSRELEEISERLEEAG---GATSV-----QIEMNKKR-EAEFQKMRRDLEEATLQH-EATAAALR 1195
Cdd:pfam15921  552 ALKLQMAEKDKVIEILRQQIENMTQLVGQHGrtaGAMQVekaqlEKEINDRRlELQEFKILKDKKDAKIRElEARVSDLE 631
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1196 KKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDF 1275
Cdd:pfam15921  632 LEKVKLVNAGSERLRAVKDIKQERDQLLNEVKTSRNELNSLSEDYEVLKRNFRNKSEEMETTTNKLKMQLKSAQSELEQT 711
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1276 TTQRAKLQTENGE-------LARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSSRH-------D 1341
Cdd:pfam15921  712 RNTLKSMEGSDGHamkvamgMQKQITAKRGQIDALQSKIQFLEEAMTNANKEKHFLKEEKNKLSQELSTVATeknkmagE 791
                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6754774    1342 CDLLREQYEEEMEAKAELQRVLSKANSEVAQWRtkyetDAIQRTEElEEAKKKLAQRLQDAE 1403
Cdd:pfam15921  792 LEVLRSQERRLKEKVANMEVALDKASLQFAECQ-----DIIQRQEQ-ESVRLKLQHTLDVKE 847
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
845-1583 1.30e-14

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 80.02  E-value: 1.30e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     845 AETEKEMANMKEEFGRVKDALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKIQLEAKVKEM 924
Cdd:pfam02463  275 KEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKEKKKAEKELKKEKEEIEELEKELKELEIKREAE 354
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     925 TERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEA 1004
Cdd:pfam02463  355 EEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELELKSEEEKEAQLLLELARQLEDLLKEEKKEELEILEE 434
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1005 HQQALDDLQA--EEDKVNTLTKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLE----NDKLQL 1078
Cdd:pfam02463  435 EEESIELKQGklTEEKEELEKQELKLLKDELELKKSEDLLKETQLVKLQEQLELLLSRQKLEERSQKESKarsgLKVLLA 514
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1079 EEKLKKKEFDISQQNSKIEDEQALALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGA 1158
Cdd:pfam02463  515 LIKDGVGGRIISAHGRLGDLGVAVENYKVAISTAVIVEVSATADEVEERQKLVRALTELPLGARKLRLLIPKLKLPLKSI 594
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1159 TSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSefKLELDDVTSNME 1238
Cdd:pfam02463  595 AVLEIDPILNLAQLDKATLEADEDDKRAKVVEGILKDTELTKLKESAKAKESGLRKGVSLEEGLAE--KSEVKASLSELT 672
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1239 QIIKAKANLEKVSRTLEDQANEY-RVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDL 1317
Cdd:pfam02463  673 KELLEIQELQEKAESELAKEEILrRQLEIKKKEQREKEELKKLKLEAEELLADRVQEAQDKINEELKLLKQKIDEEEEEE 752
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1318 KRQLEEEGKAKNALAHALQSSRHDcDLLREQYEEEMEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQ 1397
Cdd:pfam02463  753 EKSRLKKEEKEEEKSELSLKEKEL-AEEREKTEKLKVEEEKEEKLKAQEEELRALEEELKEEAELLEEEQLLIEQEEKIK 831
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1398 RLQDAEEAVEavnakcsSLEKTKHRLQNEIEDLMVDVErsnaAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEAR 1477
Cdd:pfam02463  832 EEELEELALE-------LKEEQKLEKLAEEELERLEEE----ITKEELLQELLLKEEELEEQKLKDELESKEEKEKEEKK 900
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1478 SLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKIRKQLEVEKLELQSALEEAEASLEHEE 1557
Cdd:pfam02463  901 ELEEESQKLNLLEEKENEIEERIKEEAEILLKYEEEPEELLLEEADEKEKEENNKEEEEERNKRLLLAKEELGKVNLMAI 980
                          730       740
                   ....*....|....*....|....*.
gi 6754774    1558 GKILRAQLEFNQIKAEIERKLAEKDE 1583
Cdd:pfam02463  981 EEFEEKEERYNKDELEKERLEEEKKK 1006
Myosin_N pfam02736
Myosin N-terminal SH3-like domain; This domain has an SH3-like fold. It is found at the ...
32-76 2.79e-14

Myosin N-terminal SH3-like domain; This domain has an SH3-like fold. It is found at the N-terminus of many but not all myosins. The function of this domain is unknown.


Pssm-ID: 460670  Cd Length: 45  Bit Score: 68.61  E-value: 2.79e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 6754774      32 DIRTECFVPDDKEEYVKAKVVSREGGKVTAETENGKTVTIKEDQV 76
Cdd:pfam02736    1 DAKKLVWVPDPKEGFVKGEIKEEEGDKVTVETEDGKTVTVKKDDV 45
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
1238-1929 2.93e-14

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 78.96  E-value: 2.93e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1238 EQIIKAKANLEKVSRTLE------DQANEYRVKLEEAQRSLNDFTTQRAKLQ-TENGELARQLEEKEALISQLTRGKLSY 1310
Cdd:TIGR02169  170 RKKEKALEELEEVEENIErldliiDEKRQQLERLRREREKAERYQALLKEKReYEGYELLKEKEALERQKEAIERQLASL 249
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1311 TQQMEDLKRQLEEEGKAKNALAHalqssrhdcdlLREQYEEEMEAKAElqrvlskanSEVAQWRTKYETDAIQRtEELEE 1390
Cdd:TIGR02169  250 EEELEKLTEEISELEKRLEEIEQ-----------LLEELNKKIKDLGE---------EEQLRVKEKIGELEAEI-ASLER 308
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1391 AKKKLAQRLQDAEEAVEavnakcsSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKkqrnfdkILAEWKQKYEESQSELE 1470
Cdd:TIGR02169  309 SIAEKERELEDAEERLA-------KLEAEIDKLLAEIEELEREIEEERKRRDKLTE-------EYAELKEELEDLRAELE 374
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1471 SSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEggknvheLEKIRKQLEVEKLELQSALEEAE 1550
Cdd:TIGR02169  375 EVDKEFAETRDELKDYREKLEKLKREINELKRELDRLQEELQRLSEELAD-------LNAAIAGIEAKINELEEEKEDKA 447
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1551 ASLEHEEGKILRAQLEFNQIKAEIERKLAEKD---EEMEQAKRNHLRMVDSLQTSLDAETRSRNEALRVKKKMEG----- 1622
Cdd:TIGR02169  448 LEIKKQEWKLEQLAADLSKYEQELYDLKEEYDrveKELSKLQRELAEAEAQARASEERVRGGRAVEEVLKASIQGvhgtv 527
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1623 -DLNEME------IQLSQANR----------IASEAQKHLKNSQA---------HLKDTQLQLDDAVHAN---------- 1666
Cdd:TIGR02169  528 aQLGSVGeryataIEVAAGNRlnnvvveddaVAKEAIELLKRRKAgratflplnKMRDERRDLSILSEDGvigfavdlve 607
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1667 -DDLKENIAIVERRNNLLQAELEELRAVVEQ----------------------TERSRKL----AEQELIETSERVQLLH 1719
Cdd:TIGR02169  608 fDPKYEPAFKYVFGDTLVVEDIEAARRLMGKyrmvtlegelfeksgamtggsrAPRGGILfsrsEPAELQRLRERLEGLK 687
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1720 SQNTSLINQKKKMESDLTQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRL 1799
Cdd:TIGR02169  688 RELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEARI 767
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1800 DEAEQiALKGGKKQLQKLEAR-----VRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLMRLQDLVDKLQ 1874
Cdd:TIGR02169  768 EELEE-DLHKLEEALNDLEARlshsrIPEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLK 846
                          730       740       750       760       770
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 6754774    1875 LKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDI 1929
Cdd:TIGR02169  847 EQIKSIEKEIENLNGKKEELEEELEELEAALRDLESRLGDLKKERDELEAQLREL 901
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
839-1387 3.35e-14

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 78.57  E-value: 3.35e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    839 KPLLKSAETEKEMANMKEEFGRVKDALEKSEARRKELEEKMVSLLQEKNDLQlqvqAEQDNLNDAEERCDQLIKNKIQLE 918
Cdd:PRK03918  183 KFIKRTENIEELIKEKEKELEEVLREINEISSELPELREELEKLEKEVKELE----ELKEEIEELEKELESLEGSKRKLE 258
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    919 AKVKEMTERLEdeeemnaELTAKKRKLED-------------ECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMA 985
Cdd:PRK03918  259 EKIRELEERIE-------ELKKEIEELEEkvkelkelkekaeEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIK 331
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    986 GLDEIIAKLTKEKKALQEahqqALDDLQAEEDKVNTLTKSKVKLEQ--QVDDLEGSLEQEKKVRM--DLERAKRKLEGDL 1061
Cdd:PRK03918  332 ELEEKEERLEELKKKLKE----LEKRLEELEERHELYEEAKAKKEEleRLKKRLTGLTPEKLEKEleELEKAKEEIEEEI 407
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1062 KLTQESIMDLENDKLQLE---EKLKKKEF-------------------DISQQNSKIEDEQALALQLQKKLKENQARIEE 1119
Cdd:PRK03918  408 SKITARIGELKKEIKELKkaiEELKKAKGkcpvcgrelteehrkelleEYTAELKRIEKELKEIEEKERKLRKELRELEK 487
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1120 LEEELEAERTARAKVEKLRS-----------DLSRELEEISERLEEAGGATSVQIEMNK--KREAEFQKMRRDLEEATLQ 1186
Cdd:PRK03918  488 VLKKESELIKLKELAEQLKEleeklkkynleELEKKAEEYEKLKEKLIKLKGEIKSLKKelEKLEELKKKLAELEKKLDE 567
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1187 HEATAAALRKKHAD----SVAELGEQIDNLQRVKQK---LEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEdqan 1259
Cdd:PRK03918  568 LEEELAELLKELEElgfeSVEELEERLKELEPFYNEyleLKDAEKELEREEKELKKLEEELDKAFEELAETEKRLE---- 643
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1260 EYRVKLEEAQRSLNDftTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALaHALQSSR 1339
Cdd:PRK03918  644 ELRKELEELEKKYSE--EEYEELREEYLELSRELAGLRAELEELEKRREEIKKTLEKLKEELEEREKAKKEL-EKLEKAL 720
                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|...
gi 6754774   1340 HDCDLLREQY-----EEEMEAKAELQRVLSKANSEVAQwrTKYETDAIQRTEE 1387
Cdd:PRK03918  721 ERVEELREKVkkykaLLKERALSKVGEIASEIFEELTE--GKYSGVRVKAEEN 771
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
1055-1589 4.12e-14

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 78.14  E-value: 4.12e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1055 RKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDISQQNSKIEDEQALALQLQKKLKENQARIeeleeeleaertarakv 1134
Cdd:TIGR04523   36 KQLEKKLKTIKNELKNKEKELKNLDKNLNKDEEKINNSNNKIKILEQQIKDLNDKLKKNKDKI----------------- 98
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1135 EKLRSDLSRELEEISERLEEaggatsvqieMNKKrEAEFQKMRRDLEEATLQHEATAAALRKKHADsVAELGEQIDNLQR 1214
Cdd:TIGR04523   99 NKLNSDLSKINSEIKNDKEQ----------KNKL-EVELNKLEKQKKENKKNIDKFLTEIKKKEKE-LEKLNNKYNDLKK 166
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1215 VKQKLEKEKSEFKLELDDVTSNMEQI-------------IKAK-----------ANLEKVSRTLEDQANEYRVKLEEAQR 1270
Cdd:TIGR04523  167 QKEELENELNLLEKEKLNIQKNIDKIknkllklelllsnLKKKiqknkslesqiSELKKQNNQLKDNIEKKQQEINEKTT 246
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1271 SLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNA-----LAHALQSSRHDCDLL 1345
Cdd:TIGR04523  247 EISNTQTQLNQLKDEQNKIKKQLSEKQKELEQNNKKIKELEKQLNQLKSEISDLNNQKEQdwnkeLKSELKNQEKKLEEI 326
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1346 REQYEEEMEAKAELQRVLSKANSEvaqwRTKYETDAIQRTEELEEAKKK------------------------LAQRLQD 1401
Cdd:TIGR04523  327 QNQISQNNKIISQLNEQISQLKKE----LTNSESENSEKQRELEEKQNEieklkkenqsykqeiknlesqindLESKIQN 402
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1402 AEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLST 1481
Cdd:TIGR04523  403 QEKLNQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESLETQLKVLSRSINKIKQ 482
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1482 ELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKIRKQLEVEKLELQSALEEAEASLEHE--EGK 1559
Cdd:TIGR04523  483 NLEQKQKELKSKEKELKKLNEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEKESKISDLEDELNKDDFELKKEnlEKE 562
                          570       580       590
                   ....*....|....*....|....*....|
gi 6754774    1560 ILRAQLEFNQIKAEIERKLAEKDEEMEQAK 1589
Cdd:TIGR04523  563 IDEKNKEIEELKQTQKSLKKKQEEKQELID 592
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
1572-1931 5.30e-14

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 78.19  E-value: 5.30e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1572 AEIERKLAEKDEEMEQAKRNHLR---MVDSLQTSLDAETRSRNEALRV------KKKMEG-----DLNEMEIQLSQANRI 1637
Cdd:TIGR02169  166 AEFDRKKEKALEELEEVEENIERldlIIDEKRQQLERLRREREKAERYqallkeKREYEGyellkEKEALERQKEAIERQ 245
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1638 ASEAQKHLKNSQAHLKDTQLQLDDAVHANDDLKENI-AIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQ 1716
Cdd:TIGR02169  246 LASLEEELEKLTEEISELEKRLEEIEQLLEELNKKIkDLGEEEQLRVKEKIGELEAEIASLERSIAEKERELEDAEERLA 325
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1717 LLHSQNTSLINQKKKMESDLTQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSahlermkKNMEQTIKDLQ 1796
Cdd:TIGR02169  326 KLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETRDEL-------KDYREKLEKLK 398
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1797 HRLDEAEQIALKGGKkQLQKLEARVRELENELEAEQKRNAESvkgmrksERRIKELTYQTEEDKKNLMRLQDLVDKLQLK 1876
Cdd:TIGR02169  399 REINELKRELDRLQE-ELQRLSEELADLNAAIAGIEAKINEL-------EEEKEDKALEIKKQEWKLEQLAADLSKYEQE 470
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 6754774    1877 VKAYKRQAEEAEEqantnlsKFRKVQHELDEAEERADIAESQVNKLRAKSRDIGA 1931
Cdd:TIGR02169  471 LYDLKEEYDRVEK-------ELSKLQRELAEAEAQARASEERVRGGRAVEEVLKA 518
PTZ00121 PTZ00121
MAEBL; Provisional
1293-1921 1.41e-13

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 76.72  E-value: 1.41e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1293 LEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAkNALAHALQSSRHDCDLLREQYEEEMEAKAELQRVLSKANSEVAQ 1372
Cdd:PTZ00121 1026 IEKIEELTEYGNNDDVLKEKDIIDEDIDGNHEGKA-EAKAHVGQDEGLKPSYKDFDFDAKEDNRADEATEEAFGKAEEAK 1104
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1373 wrtKYETDAIQRTEELEEAKKKL--------AQRLQDAEEAVEAVNAKCSSLEKTKHRLQN----EIEDLMVDVERSNAA 1440
Cdd:PTZ00121 1105 ---KTETGKAEEARKAEEAKKKAedarkaeeARKAEDARKAEEARKAEDAKRVEIARKAEDarkaEEARKAEDAKKAEAA 1181
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1441 AAALDKKQ-----RNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLT 1515
Cdd:PTZ00121 1182 RKAEEVRKaeelrKAEDARKAEAARKAEEERKAEEARKAEDAKKAEAVKKAEEAKKDAEEAKKAEEERNNEEIRKFEEAR 1261
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1516 EQLGEGGKNVHELEKIRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRM 1595
Cdd:PTZ00121 1262 MAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEA 1341
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1596 VDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSQANRIASEAQKHLKNSQAHLKDTQLQlddavHANDDLKENIAI 1675
Cdd:PTZ00121 1342 KKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDK-----KKADELKKAAAA 1416
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1676 VERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQllHSQNTSLINQKKKMESDLTQLQTEVEEAVQECRNAEE 1755
Cdd:PTZ00121 1417 KKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAK--KAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEE 1494
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1756 KAKKAitDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEaRVRELENELEAEQKRN 1835
Cdd:PTZ00121 1495 AKKKA--DEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAE-ELKKAEEKKKAEEAKK 1571
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1836 AESVKGM--RKSE-------RRIKELTYQTEEDKKnlMRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKF----RKVQ 1902
Cdd:PTZ00121 1572 AEEDKNMalRKAEeakkaeeARIEEVMKLYEEEKK--MKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKeaeeKKKA 1649
                         650
                  ....*....|....*....
gi 6754774   1903 HELDEAEERADIAESQVNK 1921
Cdd:PTZ00121 1650 EELKKAEEENKIKAAEEAK 1668
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1032-1640 1.44e-13

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 76.26  E-value: 1.44e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1032 QVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKkefdISQQNSKIEdeqalalQLQKKLK 1111
Cdd:PRK03918  156 GLDDYENAYKNLGEVIKEIKRRIERLEKFIKRTENIEELIKEKEKELEEVLRE----INEISSELP-------ELREELE 224
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1112 ENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEeaggatsvQIEMNKKREAEFQKMRRDLEEAtlqheata 1191
Cdd:PRK03918  225 KLEKEVKELEELKEEIEELEKELESLEGSKRKLEEKIRELEE--------RIEELKKEIEELEEKVKELKEL-------- 288
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1192 aalrKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRvKLEEAQRS 1271
Cdd:PRK03918  289 ----KEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELEEKEERLEELKKKLKELEKRLE-ELEERHEL 363
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1272 LNDFTTQRAKLQTENGELA-RQLEEKEALISQLTRGKLSYTQQMEDL---KRQLEEEGKAKNALAHALQSSRHDCDL--- 1344
Cdd:PRK03918  364 YEEAKAKKEELERLKKRLTgLTPEKLEKELEELEKAKEEIEEEISKItarIGELKKEIKELKKAIEELKKAKGKCPVcgr 443
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1345 ---------LREQYEEEM-----------EAKAELQRVLSKANSEVAQWRT--KYETDAIQRTEELEEAKKKLAQRLQDA 1402
Cdd:PRK03918  444 elteehrkeLLEEYTAELkriekelkeieEKERKLRKELRELEKVLKKESEliKLKELAEQLKELEEKLKKYNLEELEKK 523
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1403 EEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTE 1482
Cdd:PRK03918  524 AEEYEKLKEKLIKLKGEIKSLKKELEKLEELKKKLAELEKKLDELEEELAELLKELEELGFESVEELEERLKELEPFYNE 603
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1483 LFKLKNA---YEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKI-----RKQLEVEKLELQSALEEAEASLE 1554
Cdd:PRK03918  604 YLELKDAekeLEREEKELKKLEEELDKAFEELAETEKRLEELRKELEELEKKyseeeYEELREEYLELSRELAGLRAELE 683
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1555 HEEGKIlraqlefNQIKAEIErKLAEKDEEMEQAKRNhlrmVDSLQTSLDAETRSRNEALRVKKKMEgdlnemEIQLSQA 1634
Cdd:PRK03918  684 ELEKRR-------EEIKKTLE-KLKEELEEREKAKKE----LEKLEKALERVEELREKVKKYKALLK------ERALSKV 745

                  ....*.
gi 6754774   1635 NRIASE 1640
Cdd:PRK03918  746 GEIASE 751
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
1260-1842 2.77e-13

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 75.46  E-value: 2.77e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1260 EYRVKLEEAQRSLNDFttqRAKLQTENGELARQLEEKEA--LISQLTRGKLSYTQQMEDLKRQLEEEGKAKnalahalqS 1337
Cdd:PRK02224  166 EYRERASDARLGVERV---LSDQRGSLDQLKAQIEEKEEkdLHERLNGLESELAELDEEIERYEEQREQAR--------E 234
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1338 SRHDCDLLREQYEEEMEAKAELQRVLSKANSEVAQWRTKYET------DAIQRTEELEEAKKKLAQRLQDAEEAVEAVNA 1411
Cdd:PRK02224  235 TRDEADEVLEEHEERREELETLEAEIEDLRETIAETEREREElaeevrDLRERLEELEEERDDLLAEAGLDDADAEAVEA 314
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1412 KCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQkyeesqselessqkEARSLSTELfklknayE 1491
Cdd:PRK02224  315 RREELEDRDEELRDRLEECRVAAQAHNEEAESLREDADDLEERAEELRE--------------EAAELESEL-------E 373
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1492 ESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKIRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIK 1571
Cdd:PRK02224  374 EAREAVEDRREEIEELEEEIEELRERFGDAPVDLGNAEDFLEELREERDELREREAELEATLRTARERVEEAEALLEAGK 453
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1572 -----------------AEIERKLAEKDEEMEQAKRNHLRMVDSLQTSLDA-ETRSRNEALRVKKKMEGDL-----NEME 1628
Cdd:PRK02224  454 cpecgqpvegsphvetiEEDRERVEELEAELEDLEEEVEEVEERLERAEDLvEAEDRIERLEERREDLEELiaerrETIE 533
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1629 IQLSQANRIASEAQKHLKNSQAHLKDTQLQLDDAvhanDDLKENIAIVERRNNLLQAELEELRAVVEQTERsRKLAEQEL 1708
Cdd:PRK02224  534 EKRERAEELRERAAELEAEAEEKREAAAEAEEEA----EEAREEVAELNSKLAELKERIESLERIRTLLAA-IADAEDEI 608
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1709 IETSERVQLLHSQNTSLINQKKKMESDLTQLQTEVEEA-VQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKN 1787
Cdd:PRK02224  609 ERLREKREALAELNDERRERLAEKRERKRELEAEFDEArIEEAREDKERAEEYLEQVEEKLDELREERDDLQAEIGAVEN 688
                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 6754774   1788 MEQTIKDLQHRLDeaeqiALKGGKKQLQKLEARVRELEN---ELEAE-QKRNAESVKGM 1842
Cdd:PRK02224  689 ELEELEELRERRE-----ALENRVEALEALYDEAEELESmygDLRAElRQRNVETLERM 742
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1383-1910 3.34e-13

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 75.10  E-value: 3.34e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1383 QRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKhrlqNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEwKQKY 1462
Cdd:PRK03918  200 KELEEVLREINEISSELPELREELEKLEKEVKELEELK----EEIEELEKELESLEGSKRKLEEKIRELEERIEE-LKKE 274
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1463 EESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKIRKQLEveklEL 1542
Cdd:PRK03918  275 IEELEEKVKELKELKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELEEKEERLEELKKKLK----EL 350
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1543 QSALEEAEASLE-HEEGKILRAQLEfnQIKAEIE----RKLAEKDEEMEQAK---RNHLRMVDSLQTSLDAETRSRNEAL 1614
Cdd:PRK03918  351 EKRLEELEERHElYEEAKAKKEELE--RLKKRLTgltpEKLEKELEELEKAKeeiEEEISKITARIGELKKEIKELKKAI 428
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1615 RVKKKMEGD--LNEMEIQLSQANRIASEAQKHLKNSQAHLKDTQLQLDDavhanddlkeniaiverrnnlLQAELEELRA 1692
Cdd:PRK03918  429 EELKKAKGKcpVCGRELTEEHRKELLEEYTAELKRIEKELKEIEEKERK---------------------LRKELRELEK 487
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1693 VVEQTERSRKLAEqelietservqllhsqntsLINQKKKMESDLTQLQTE-VEEAVQECRNAEEKAKKAITDAAMMAEEL 1771
Cdd:PRK03918  488 VLKKESELIKLKE-------------------LAEQLKELEEKLKKYNLEeLEKKAEEYEKLKEKLIKLKGEIKSLKKEL 548
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1772 KKEQD---TSAHLERMKKNMEQTIKDLQHRLDEA--------------------EQIALKGGKKQLQKLEARVRELENEL 1828
Cdd:PRK03918  549 EKLEElkkKLAELEKKLDELEEELAELLKELEELgfesveeleerlkelepfynEYLELKDAEKELEREEKELKKLEEEL 628
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1829 EAEQKRNAESVKGMRKSERRIKELtyQTEEDKKNLMRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEA 1908
Cdd:PRK03918  629 DKAFEELAETEKRLEELRKELEEL--EKKYSEEEYEELREEYLELSRELAGLRAELEELEKRREEIKKTLEKLKEELEER 706

                  ..
gi 6754774   1909 EE 1910
Cdd:PRK03918  707 EK 708
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
1486-1928 3.93e-13

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 75.15  E-value: 3.93e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1486 LKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNvHE--LEKIRKQLeveklelqSALEEAEASLEHEEGKIlrA 1563
Cdd:pfam15921  143 LRNQLQNTVHELEAAKCLKEDMLEDSNTQIEQLRKMMLS-HEgvLQEIRSIL--------VDFEEASGKKIYEHDSM--S 211
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1564 QLEFNQIKAEIERKLAEKDEEMEQAKRNHLRMVDSLQTsLDAETRSRNEAL--RVKKKMEGDLNEMEIQLSQANRIASEA 1641
Cdd:pfam15921  212 TMHFRSLGSAISKILRELDTEISYLKGRIFPVEDQLEA-LKSESQNKIELLlqQHQDRIEQLISEHEVEITGLTEKASSA 290
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1642 QKHLKNSQAHLKDTQLQlddavhanddlkeniaiVERRNNLLQAELEELRAVVEQTE---RSRKLAEQELIETSERVQLL 1718
Cdd:pfam15921  291 RSQANSIQSQLEIIQEQ-----------------ARNQNSMYMRQLSDLESTVSQLRselREAKRMYEDKIEELEKQLVL 353
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1719 HSqntslinqkkkmeSDLTQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHR 1798
Cdd:pfam15921  354 AN-------------SELTEARTERDQFSQESGNLDDQLQKLLADLHKREKELSLEKEQNKRLWDRDTGNSITIDHLRRE 420
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1799 LDEAEQialkggkkQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLMRLQDLVDKLQLKVK 1878
Cdd:pfam15921  421 LDDRNM--------EVQRLEALLKAMKSECQGQMERQMAAIQGKNESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTLE 492
                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6754774    1879 AYKR----------QAEEAEEQANTNLSKFR--------KVQHELDEAEERADI-AESQVNKLRAKSRD 1928
Cdd:pfam15921  493 SSERtvsdltaslqEKERAIEATNAEITKLRsrvdlklqELQHLKNEGDHLRNVqTECEALKLQMAEKD 561
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
1039-1929 9.28e-13

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 73.93  E-value: 9.28e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1039 SLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDISQQNSKiEDEQALALQLQKKLKENQARIE 1118
Cdd:TIGR00606  187 ALETLRQVRQTQGQKVQEHQMELKYLKQYKEKACEIRDQITSKEAQLESSREIVKSY-ENELDPLKNRLKEIEHNLSKIM 265
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1119 ELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGatsvQIEMNKKREA-EFQKMRRDLEEATLQHEATAAALRKK 1197
Cdd:TIGR00606  266 KLDNEIKALKSRKKQMEKDNSELELKMEKVFQGTDEQLN----DLYHNHQRTVrEKERELVDCQRELEKLNKERRLLNQE 341
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1198 HADSVAELGE-----QIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSL 1272
Cdd:TIGR00606  342 KTELLVEQGRlqlqaDRHQEHIRARDSLIQSLATRLELDGFERGPFSERQIKNFHTLVIERQEDEAKTAAQLCADLQSKE 421
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1273 NDFTTQRAKLQTENGELARQLEEKEALISQLT---RGKLSYTQQ----MEDLKRQLEEEGKAKNALAHALQSSRHDCDLL 1345
Cdd:TIGR00606  422 RLKQEQADEIRDEKKGLGRTIELKKEILEKKQeelKFVIKELQQlegsSDRILELDQELRKAERELSKAEKNSLTETLKK 501
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1346 REQYEEemEAKAELQRVLSKANSEVAQWRTKYETdaiqRTEELEEAKKKLaqrlqDAEEAVEAVNAKCSS---------- 1415
Cdd:TIGR00606  502 EVKSLQ--NEKADLDRKLRKLDQEMEQLNHHTTT----RTQMEMLTKDKM-----DKDEQIRKIKSRHSDeltsllgyfp 570
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1416 ----LEKTKHRLQNEI---EDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEES-------------QSELESSQKE 1475
Cdd:TIGR00606  571 nkkqLEDWLHSKSKEInqtRDRLAKLNKELASLEQNKNHINNELESKEEQLSSYEDKlfdvcgsqdeesdLERLKEEIEK 650
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1476 ARSLSTELFKLKNAYEESLEHLET------------FKREnKNLQEEISDLTEQLGEGGKNVHELEKIRKQLEVEKLELQ 1543
Cdd:TIGR00606  651 SSKQRAMLAGATAVYSQFITQLTDenqsccpvcqrvFQTE-AELQEFISDLQSKLRLAPDKLKSTESELKKKEKRRDEML 729
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1544 SALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLA--EKDEEMEQAKRNHLRMVDSLQTSLDAETRSRNEALRVKKKME 1621
Cdd:TIGR00606  730 GLAPGRQSIIDLKEKEIPELRNKLQKVNRDIQRLKNdiEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIA 809
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1622 GDLNEMeiQLSQANRIASEAQKHLKNSQAHLKDTQLQLDDAVHANDDLKENIAIVERRNNLLQAELEELRavvEQTERSR 1701
Cdd:TIGR00606  810 QQAAKL--QGSDLDRTVQQVNQEKQEKQHELDTVVSKIELNRKLIQDQQEQIQHLKSKTNELKSEKLQIG---TNLQRRQ 884
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1702 KLAEQeLIETSERVQLLHSQNTSLINQKKKMESDLTQLQTEVEEAVQecrNAEEKAKKAITDAAMMAEELKK-------- 1773
Cdd:TIGR00606  885 QFEEQ-LVELSTEVQSLIREIKDAKEQDSPLETFLEKDQQEKEELIS---SKETSNKKAQDKVNDIKEKVKNihgymkdi 960
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1774 EQDTSAHLERMKKNMEQTIKDLQHRLDEAEQialkggkkQLQKLEARVRELENELEAE--QKRNAESVKGMRKSERRIKE 1851
Cdd:TIGR00606  961 ENKIQDGKDDYLKQKETELNTVNAQLEECEK--------HQEKINEDMRLMRQDIDTQkiQERWLQDNLTLRKRENELKE 1032
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1852 L-----TYQTEEDKKNLMRLQDLVDKLQLKVKAYKR-------QAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQV 1919
Cdd:TIGR00606 1033 VeeelkQHLKEMGQMQVLQMKQEHQKLEENIDLIKRnhvlalgRQKGYEKEIKHFKKELREPQFRDAEEKYREMMIVMRT 1112
                          970
                   ....*....|
gi 6754774    1920 NKLRAKSRDI 1929
Cdd:TIGR00606 1113 TELVNKDLDI 1122
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
942-1576 1.91e-12

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 73.03  E-value: 1.91e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   942 KRKLEDECSELKKDIDDLELTLAKVEKEKHATE--NKVKNLTEEMAGLDEIIAKLTKEKKALQ-EAHQQALDDLQAEEDK 1018
Cdd:COG4913  220 EPDTFEAADALVEHFDDLERAHEALEDAREQIEllEPIRELAERYAAARERLAELEYLRAALRlWFAQRRLELLEAELEE 299
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1019 vntLTKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDlkltqeSIMDLENDKLQLEEKLKKKEFDISQQNSKIED 1098
Cdd:COG4913  300 ---LRAELARLEAELERLEARLDALREELDELEAQIRGNGGD------RLEQLEREIERLERELEERERRRARLEALLAA 370
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1099 EQALALQLQKKLKENQARIEELEEELEAER----TARAKVEKLRSDLSRELEEISERLEEaggatsvqIEMNKKR-EAEF 1173
Cdd:COG4913  371 LGLPLPASAEEFAALRAEAAALLEALEEELealeEALAEAEAALRDLRRELRELEAEIAS--------LERRKSNiPARL 442
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1174 QKMRRDLEEATLQHEA-------------------TAA--ALR---------KKHADSVAELGEQID-----NLQRVKQK 1218
Cdd:COG4913  443 LALRDALAEALGLDEAelpfvgelievrpeeerwrGAIerVLGgfaltllvpPEHYAAALRWVNRLHlrgrlVYERVRTG 522
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1219 LEKEKSEF--------KLELDD--VTSNMEQIIKAKANLEKVsRTLEDQANEYR-------VKLEEAQRSLNDFTTQRAK 1281
Cdd:COG4913  523 LPDPERPRldpdslagKLDFKPhpFRAWLEAELGRRFDYVCV-DSPEELRRHPRaitragqVKGNGTRHEKDDRRRIRSR 601
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1282 LQT--ENgelARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSSRHDCDLlrEQYEEEMEAKAEL 1359
Cdd:COG4913  602 YVLgfDN---RAKLAALEAELAELEEELAEAEERLEALEAELDALQERREALQRLAEYSWDEIDV--ASAEREIAELEAE 676
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1360 QRVLSKANSEVaqwrtkyetdaiqrtEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVErsna 1439
Cdd:COG4913  677 LERLDASSDDL---------------AALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLE---- 737
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1440 AAAALDKKQRNFDkiLAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKnlqeeisDLTEQLG 1519
Cdd:COG4913  738 AAEDLARLELRAL--LEERFAAALGDAVERELRENLEERIDALRARLNRAEEELERAMRAFNREWP-------AETADLD 808
                        650       660       670       680       690       700
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1520 EGGKNVHELEKIRKQLEVEKL-ELQSALEEAEASLEHEEGKILRAQL--EFNQIKAEIER 1576
Cdd:COG4913  809 ADLESLPEYLALLDRLEEDGLpEYEERFKELLNENSIEFVADLLSKLrrAIREIKERIDP 868
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
1571-1935 2.30e-12

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 72.78  E-value: 2.30e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1571 KAEIERKLAEKDEEMEQAKRNhLRMVDSLQTSLDAETRSRNEALRVKKKME--------GDLNEMEIQLSQANRIASEAQ 1642
Cdd:TIGR02168  174 RKETERKLERTRENLDRLEDI-LNELERQLKSLERQAEKAERYKELKAELRelelallvLRLEELREELEELQEELKEAE 252
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1643 KHLKNSQAHLKDTQLQLDDAVHANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQN 1722
Cdd:TIGR02168  253 EELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKL 332
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1723 TSLINQKKKMESDLTQLQTEVEEavqecrnaeekakkaitdaamMAEELKKeqdtsahLERMKKNMEQTIKDLQHRLDEA 1802
Cdd:TIGR02168  333 DELAEELAELEEKLEELKEELES---------------------LEAELEE-------LEAELEELESRLEELEEQLETL 384
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1803 EQiALKGGKKQLQKLEARVRELENELEAEQKRNAESVKgmRKSERRIKELTYQTEEDKKNLMRLQDLVDKLQLKVKAYKR 1882
Cdd:TIGR02168  385 RS-KVAQLELQIASLNNEIERLEARLERLEDRRERLQQ--EIEELLKKLEEAELKELQAELEELEEELEELQEELERLEE 461
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|...
gi 6754774    1883 QAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDIGAKKMH 1935
Cdd:TIGR02168  462 ALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKN 514
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
1310-1907 3.48e-12

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 72.07  E-value: 3.48e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1310 YTQQMEDLKRQLEEEGKAKNALAHALQSSRHDCDLLREQYEEEMEAKAELQRVLSKANSEVaqwrtkyeTDAIQRT-EEL 1388
Cdd:pfam15921   83 YSHQVKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEMQMERDAMADIRRRESQSQEDL--------RNQLQNTvHEL 154
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1389 EEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHrlqnEIEDLMVDVERSNAaaaaldkkqrnfDKILAEWKQKYEESQSE 1468
Cdd:pfam15921  155 EAAKCLKEDMLEDSNTQIEQLRKMMLSHEGVLQ----EIRSILVDFEEASG------------KKIYEHDSMSTMHFRSL 218
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1469 LESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQE-------------------EISDLTEQLGEGGKNVH--- 1526
Cdd:pfam15921  219 GSAISKILRELDTEISYLKGRIFPVEDQLEALKSESQNKIElllqqhqdrieqlisehevEITGLTEKASSARSQANsiq 298
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1527 -ELEKIRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAK--RNHL-----RMVDS 1598
Cdd:pfam15921  299 sQLEIIQEQARNQNSMYMRQLSDLESTVSQLRSELREAKRMYEDKIEELEKQLVLANSELTEARteRDQFsqesgNLDDQ 378
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1599 LQTSLdAETRSRNEALRVKKKMEGDLNEME----IQLSQANRIASEAQKHLKNSQAHLK----DTQLQLDDAVHANDDLK 1670
Cdd:pfam15921  379 LQKLL-ADLHKREKELSLEKEQNKRLWDRDtgnsITIDHLRRELDDRNMEVQRLEALLKamksECQGQMERQMAAIQGKN 457
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1671 ENIAIVERRNNLLQAELEELRAVVEQTErsrklAEQELIETSERVqlLHSQNTSLINQKKKME---SDLTQLQTEVEEAV 1747
Cdd:pfam15921  458 ESLEKVSSLTAQLESTKEMLRKVVEELT-----AKKMTLESSERT--VSDLTASLQEKERAIEatnAEITKLRSRVDLKL 530
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1748 QEC---RNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTI------------------KDLQHRLDEAEQIA 1806
Cdd:pfam15921  531 QELqhlKNEGDHLRNVQTECEALKLQMAEKDKVIEILRQQIENMTQLVgqhgrtagamqvekaqleKEINDRRLELQEFK 610
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1807 LKGGKKqlqklEARVRELE---NELEAEQKRNAESVKGMRKSERRIKELTYQ-TEEDKKNLMRLQDLVDKLQLKVKAYKR 1882
Cdd:pfam15921  611 ILKDKK-----DAKIRELEarvSDLELEKVKLVNAGSERLRAVKDIKQERDQlLNEVKTSRNELNSLSEDYEVLKRNFRN 685
                          650       660
                   ....*....|....*....|....*
gi 6754774    1883 QAEEAEEQANTNLSKFRKVQHELDE 1907
Cdd:pfam15921  686 KSEEMETTTNKLKMQLKSAQSELEQ 710
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
865-1541 3.83e-12

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 71.92  E-value: 3.83e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     865 LEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDnlnDAEERCDQLIKNKIQLEAKVKEMTERLEDEEEMNAELTAK--- 941
Cdd:TIGR00618  175 LDQYTQLALMEFAKKKSLHGKAELLTLRSQLLTL---CTPCMPDTYHERKQVLEKELKHLREALQQTQQSHAYLTQKrea 251
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     942 ---KRKLEDECSELKKDIDDLELTLAKVEKEKHATE--NKVKNLTEEMAGLDEIIAKLT------KEKKALQEAHQQALD 1010
Cdd:TIGR00618  252 qeeQLKKQQLLKQLRARIEELRAQEAVLEETQERINraRKAAPLAAHIKAVTQIEQQAQrihtelQSKMRSRAKLLMKRA 331
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1011 DLQAEEDKVNTLTKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQ--ESIMDLENDKLQLEEKLKKKEFD 1088
Cdd:TIGR00618  332 AHVKQQSSIEEQRRLLQTLHSQEIHIRDAHEVATSIREISCQQHTLTQHIHTLQQqkTTLTQKLQSLCKELDILQREQAT 411
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1089 ISQQNSKIEDEQALALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKK 1168
Cdd:TIGR00618  412 IDTRTSAFRDLQGQLAHAKKQQELQQRYAELCAAAITCTAQCEKLEKIHLQESAQSLKEREQQLQTKEQIHLQETRKKAV 491
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1169 REA---EFQKMRRDLEEATLQHEATAAAL----------------RKKHADS--------------VAELGEQIDNLQRV 1215
Cdd:TIGR00618  492 VLArllELQEEPCPLCGSCIHPNPARQDIdnpgpltrrmqrgeqtYAQLETSeedvyhqltserkqRASLKEQMQEIQQS 571
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1216 KQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEE 1295
Cdd:TIGR00618  572 FSILTQCDNRSKEDIPNLQNITVRLQDLTEKLSEAEDMLACEQHALLRKLQPEQDLQDVRLHLQQCSQELALKLTALHAL 651
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1296 KEALISQLTRGKLSYTQQMEDLKRQLEEegkaknALAHALQSSRHDCDLLREQYEEEMEAKAELQRVLSKANSEVAQWRT 1375
Cdd:TIGR00618  652 QLTLTQERVREHALSIRVLPKELLASRQ------LALQKMQSEKEQLTYWKEMLAQCQTLLRELETHIEEYDREFNEIEN 725
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1376 KYETdaiqRTEELEEAKKKLAQRLQDAEEavEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNaAAAALDKKQRNFDKIL 1455
Cdd:TIGR00618  726 ASSS----LGSDLAAREDALNQSLKELMH--QARTVLKARTEAHFNNNEEVTAALQTGAELSH-LAAEIQFFNRLREEDT 798
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1456 AEWKQKyEESQSELESSQKEARSLSTELFklknayEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKIRKQL 1535
Cdd:TIGR00618  799 HLLKTL-EAEIGQEIPSDEDILNLQCETL------VQEEEQFLSRLEEKSATLGEITHQLLKYEECSKQLAQLTQEQAKI 871

                   ....*...
gi 6754774    1536 --EVEKLE 1541
Cdd:TIGR00618  872 iqLSDKLN 879
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
848-1602 4.31e-12

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 71.62  E-value: 4.31e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     848 EKEMANMKEEFGRVKDALEKSEARRKELEEKMVSLLQEKNDLQLQ--VQAEQDNLNDAEERCDQL----------IKNKI 915
Cdd:TIGR00606  311 QRTVREKERELVDCQRELEKLNKERRLLNQEKTELLVEQGRLQLQadRHQEHIRARDSLIQSLATrleldgfergPFSER 390
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     916 QLEAKVKEMTERLEDEEEMNAELTA--------KKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGL 987
Cdd:TIGR00606  391 QIKNFHTLVIERQEDEAKTAAQLCAdlqskerlKQEQADEIRDEKKGLGRTIELKKEILEKKQEELKFVIKELQQLEGSS 470
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     988 DEIIAK---LTKEKKALQEAHQQALDDLQAEEDKV-----NTLTKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEG 1059
Cdd:TIGR00606  471 DRILELdqeLRKAERELSKAEKNSLTETLKKEVKSlqnekADLDRKLRKLDQEMEQLNHHTTTRTQMEMLTKDKMDKDEQ 550
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1060 DLKLTQESIMDLEN------DKLQLEEKLKKKEFDISQQNSKIED---EQALALQLQKKLKENQARIEELEEELEAERTA 1130
Cdd:TIGR00606  551 IRKIKSRHSDELTSllgyfpNKKQLEDWLHSKSKEINQTRDRLAKlnkELASLEQNKNHINNELESKEEQLSSYEDKLFD 630
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1131 RAKVEKLRSDLSR---ELEEISERLEEAGGATSVQ-----------------IEMNKKREAEFQKMRRDLEEATL----Q 1186
Cdd:TIGR00606  631 VCGSQDEESDLERlkeEIEKSSKQRAMLAGATAVYsqfitqltdenqsccpvCQRVFQTEAELQEFISDLQSKLRlapdK 710
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1187 HEATAAALRKKHADSVAELGeQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIikaKANLEKVSRTLEdqanEYRVKLE 1266
Cdd:TIGR00606  711 LKSTESELKKKEKRRDEMLG-LAPGRQSIIDLKEKEIPELRNKLQKVNRDIQRL---KNDIEEQETLLG----TIMPEEE 782
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1267 EAQRSLNDFTTQRaklqtengELARQLEEKEALISQLTRgklsyTQQMEDLKRQLEEEGKAKNALAHALQSSRHDCDLLR 1346
Cdd:TIGR00606  783 SAKVCLTDVTIME--------RFQMELKDVERKIAQQAA-----KLQGSDLDRTVQQVNQEKQEKQHELDTVVSKIELNR 849
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1347 EQYEEEMEAKAELQRVLSKANSEVAQWRTkyetdAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNE 1426
Cdd:TIGR00606  850 KLIQDQQEQIQHLKSKTNELKSEKLQIGT-----NLQRRQQFEEQLVELSTEVQSLIREIKDAKEQDSPLETFLEKDQQE 924
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1427 IEDLMVDVERSNAAAA-ALDKKQRNFDKILAEWK--QKYEESQSELESSQKEarslsTELFKLKNAYEESLEHLETFKRE 1503
Cdd:TIGR00606  925 KEELISSKETSNKKAQdKVNDIKEKVKNIHGYMKdiENKIQDGKDDYLKQKE-----TELNTVNAQLEECEKHQEKINED 999
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1504 NKNLQEEI-------SDLTEQLGEGGKN--VHELEKIRKQLEVEKLELQ--------SALEEAEASLEHEEGKILRAQLE 1566
Cdd:TIGR00606 1000 MRLMRQDIdtqkiqeRWLQDNLTLRKREneLKEVEEELKQHLKEMGQMQvlqmkqehQKLEENIDLIKRNHVLALGRQKG 1079
                          810       820       830
                   ....*....|....*....|....*....|....*.
gi 6754774    1567 FNQIKAEIERKLAEKdeEMEQAKRNHLRMVDSLQTS 1602
Cdd:TIGR00606 1080 YEKEIKHFKKELREP--QFRDAEEKYREMMIVMRTT 1113
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
1210-1929 8.76e-12

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 70.77  E-value: 8.76e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1210 DNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRsLNDFTTQRAKLQTENGEL 1289
Cdd:TIGR00618  187 AKKKSLHGKAELLTLRSQLLTLCTPCMPDTYHERKQVLEKELKHLREALQQTQQSHAYLTQ-KREAQEEQLKKQQLLKQL 265
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1290 ARQLEEKEALISqltrgKLSYTQQMEDLKRQLEEEGKAKNALAHALQSSRhdcdllrEQYEEEMEAKAELQRVLSKANSE 1369
Cdd:TIGR00618  266 RARIEELRAQEA-----VLEETQERINRARKAAPLAAHIKAVTQIEQQAQ-------RIHTELQSKMRSRAKLLMKRAAH 333
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1370 VAQwrtKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEdlmVDVERSNAAAAALDKKQR 1449
Cdd:TIGR00618  334 VKQ---QSSIEEQRRLLQTLHSQEIHIRDAHEVATSIREISCQQHTLTQHIHTLQQQKT---TLTQKLQSLCKELDILQR 407
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1450 NFDKILAEwKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGgKNVHELE 1529
Cdd:TIGR00618  408 EQATIDTR-TSAFRDLQGQLAHAKKQQELQQRYAELCAAAITCTAQCEKLEKIHLQESAQSLKEREQQLQTK-EQIHLQE 485
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1530 KIRKQLEVEKLELQSALE-EAEASLEHEEGK-------------ILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRM 1595
Cdd:TIGR00618  486 TRKKAVVLARLLELQEEPcPLCGSCIHPNPArqdidnpgpltrrMQRGEQTYAQLETSEEDVYHQLTSERKQRASLKEQM 565
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1596 vDSLQTSLDAETRSRNealRVKKKMEGDLNEMEIQLSQANRIASEAQKHLKNSQAHLKDTQLQLDDAVHANDDlkENIAI 1675
Cdd:TIGR00618  566 -QEIQQSFSILTQCDN---RSKEDIPNLQNITVRLQDLTEKLSEAEDMLACEQHALLRKLQPEQDLQDVRLHL--QQCSQ 639
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1676 VERRNNLLQAELEELRAVVEQTERSRKLAEQELiETSERVQLLHSQNTSLINQKKKMESDLTQLQTeveeavqecrnaee 1755
Cdd:TIGR00618  640 ELALKLTALHALQLTLTQERVREHALSIRVLPK-ELLASRQLALQKMQSEKEQLTYWKEMLAQCQT-------------- 704
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1756 kakkaitdaaMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEN---ELEAEQ 1832
Cdd:TIGR00618  705 ----------LLRELETHIEEYDREFNEIENASSSLGSDLAAREDALNQSLKELMHQARTVLKARTEAHFNnneEVTAAL 774
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1833 KRNAESVKGMRKSERRIKELTYQTEEDKKNLMRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERA 1912
Cdd:TIGR00618  775 QTGAELSHLAAEIQFFNRLREEDTHLLKTLEAEIGQEIPSDEDILNLQCETLVQEEEQFLSRLEEKSATLGEITHQLLKY 854
                          730
                   ....*....|....*..
gi 6754774    1913 DIAESQVNKLRAKSRDI 1929
Cdd:TIGR00618  855 EECSKQLAQLTQEQAKI 871
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
836-1248 9.85e-12

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 70.48  E-value: 9.85e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    836 FKIKPLLKSAETEKEMANMKEEFGRVK---DALEKSEARRKELEEKMVSLLQEKNDLQLQVQ------AEQDNLNDAEER 906
Cdd:PRK03918  301 FYEEYLDELREIEKRLSRLEEEINGIEeriKELEEKEERLEELKKKLKELEKRLEELEERHElyeeakAKKEELERLKKR 380
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    907 CDQLIKNKIqlEAKVKEMTERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLE-----LTLAKVEKEKHATEN------ 975
Cdd:PRK03918  381 LTGLTPEKL--EKELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKkakgkCPVCGRELTEEHRKElleeyt 458
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    976 -KVKNLTEEMAGLDEIIAKLTKEKKALQEA---------HQQALDDLQAEEDKVNTLTKSkvKLEQQVDDLEGSLEQEKK 1045
Cdd:PRK03918  459 aELKRIEKELKEIEEKERKLRKELRELEKVlkkeselikLKELAEQLKELEEKLKKYNLE--ELEKKAEEYEKLKEKLIK 536
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1046 VRMDLERAKRKLegdlkltqESIMDLENDKLQLEEKLKKKEFDISQQNSKI-----EDEQALALQLQK---------KLK 1111
Cdd:PRK03918  537 LKGEIKSLKKEL--------EKLEELKKKLAELEKKLDELEEELAELLKELeelgfESVEELEERLKElepfyneylELK 608
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1112 ENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVqiEMNKKREAEFQKMRRDLEEATLQHEaTA 1191
Cdd:PRK03918  609 DAEKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELEELEKKYSE--EEYEELREEYLELSRELAGLRAELE-EL 685
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 6754774   1192 AALRKKHADSVAELGEQIDNLQRVKQKLEKekseFKLELDDVTSNMEQIIKAKANLE 1248
Cdd:PRK03918  686 EKRREEIKKTLEKLKEELEEREKAKKELEK----LEKALERVEELREKVKKYKALLK 738
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
839-1520 1.35e-11

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 69.75  E-value: 1.35e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     839 KPLLKSAETEKEMANM-KEEFGRVKDALEKSEARRKELEEKMVSLlqeKNDLQLQVQAEQDNLNDAEercdqliKNKIQL 917
Cdd:pfam05483  144 KDLIKENNATRHLCNLlKETCARSAEKTKKYEYEREETRQVYMDL---NNNIEKMILAFEELRVQAE-------NARLEM 213
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     918 EAKVKEMTERLED-EEEMNAELTAKKRK---LEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAK 993
Cdd:pfam05483  214 HFKLKEDHEKIQHlEEEYKKEINDKEKQvslLLIQITEKENKMKDLTFLLEESRDKANQLEEKTKLQDENLKELIEKKDH 293
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     994 LTKEKKALQEAHQQALDDLQAEEDKVNTLTKSKVKL----EQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIM 1069
Cdd:pfam05483  294 LTKELEDIKMSLQRSMSTQKALEEDLQIATKTICQLteekEAQMEELNKAKAAHSFVVTEFEATTCSLEELLRTEQQRLE 373
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1070 DLENDKLQLEEKLKKKEFDISQQNSKIEDEQALALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEIS 1149
Cdd:pfam05483  374 KNEDQLKIITMELQKKSSELEEMTKFKNNKEVELEELKKILAEDEKLLDEKKQFEKIAEELKGKEQELIFLLQAREKEIH 453
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1150 ErLEEAGGATSVQIEMNKKreaEFQKMRRDLEEATLQHeataaalrkkhadsvAELGEQIDNLQRVKQKLEKEKSEFKLE 1229
Cdd:pfam05483  454 D-LEIQLTAIKTSEEHYLK---EVEDLKTELEKEKLKN---------------IELTAHCDKLLLENKELTQEASDMTLE 514
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1230 LDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRslnDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLS 1309
Cdd:pfam05483  515 LKKHQEDIINCKKQEERMLKQIENLEEKEMNLRDELESVRE---EFIQKGDEVKCKLDKSEENARSIEYEVLKKEKQMKI 591
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1310 YTQQMEDLKRQLEEEGKaknalahALQSSRHDCDLLREQYEEEMEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELE 1389
Cdd:pfam05483  592 LENKCNNLKKQIENKNK-------NIEELHQENKALKKKGSAENKQLNAYEIKVNKLELELASAKQKFEEIIDNYQKEIE 664
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1390 EAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMvdversnaaaAALDKKQRNFDKILAEWKQKYEESQSEL 1469
Cdd:pfam05483  665 DKKISEEKLLEEVEKAKAIADEAVKLQKEIDKRCQHKIAEMV----------ALMEKHKHQYDKIIEERDSELGLYKNKE 734
                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|.
gi 6754774    1470 ESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGE 1520
Cdd:pfam05483  735 QEQSSAKAALEIELSNIKAELLSLKKQLEIEKEEKEKLKMEAKENTAILKD 785
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
849-1772 1.57e-11

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 70.08  E-value: 1.57e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     849 KEMANMKEEFGRVKDALEKSEARRKELEEKMVSLLQEKnDLQLQVQAEQDNLNDAEERCDQLIKNKIQLEAKVKEMTERL 928
Cdd:TIGR00606  200 QKVQEHQMELKYLKQYKEKACEIRDQITSKEAQLESSR-EIVKSYENELDPLKNRLKEIEHNLSKIMKLDNEIKALKSRK 278
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     929 EDEEEMNAELTAKKRKLEDECSELKKDIDdleltlakvekekHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAH--- 1005
Cdd:TIGR00606  279 KQMEKDNSELELKMEKVFQGTDEQLNDLY-------------HNHQRTVREKERELVDCQRELEKLNKERRLLNQEKtel 345
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1006 --QQALDDLQAEEDKVNTLTKSKVKLEQQ----VDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLE 1079
Cdd:TIGR00606  346 lvEQGRLQLQADRHQEHIRARDSLIQSLAtrleLDGFERGPFSERQIKNFHTLVIERQEDEAKTAAQLCADLQSKERLKQ 425
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1080 EKLKKKEFDISQQNSKIEDEqalalqlQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAggat 1159
Cdd:TIGR00606  426 EQADEIRDEKKGLGRTIELK-------KEILEKKQEELKFVIKELQQLEGSSDRILELDQELRKAERELSKAEKNS---- 494
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1160 svQIEMNKKREAEFQKMRRDLEEaTLQHEATAAALRKKHADSVaelgEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQ 1239
Cdd:TIGR00606  495 --LTETLKKEVKSLQNEKADLDR-KLRKLDQEMEQLNHHTTTR----TQMEMLTKDKMDKDEQIRKIKSRHSDELTSLLG 567
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1240 IIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLndfttqrAKLQTENGELARQLEEKEALISQLTR------GKLSYTQQ 1313
Cdd:TIGR00606  568 YFPNKKQLEDWLHSKSKEINQTRDRLAKLNKEL-------ASLEQNKNHINNELESKEEQLSSYEDklfdvcGSQDEESD 640
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1314 MEDLKRQLEEEGKAKNALAHALQSSRHDCDLLREQY-------EEEMEAKAELQRVLSKANSEVAQWRTKYEtdaiQRTE 1386
Cdd:TIGR00606  641 LERLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENqsccpvcQRVFQTEAELQEFISDLQSKLRLAPDKLK----STES 716
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1387 ELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQN---EIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYE 1463
Cdd:TIGR00606  717 ELKKKEKRRDEMLGLAPGRQSIIDLKEKEIPELRNKLQKvnrDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMER 796
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1464 ESQSELESSQKEARSLS-TELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKIRKQLEVEKLEL 1542
Cdd:TIGR00606  797 FQMELKDVERKIAQQAAkLQGSDLDRTVQQVNQEKQEKQHELDTVVSKIELNRKLIQDQQEQIQHLKSKTNELKSEKLQI 876
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1543 QSALEEAEASLEHEEGKILRAQLEFNQIK---------AEIERKLAEKDEEMEQAKRNHLRMVDSLQTSLDAETRSRNEA 1613
Cdd:TIGR00606  877 GTNLQRRQQFEEQLVELSTEVQSLIREIKdakeqdsplETFLEKDQQEKEELISSKETSNKKAQDKVNDIKEKVKNIHGY 956
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1614 LR-----VKKKMEGDLNEMEIQLSQANRIASEAQKHLKNSQAHLKDTQLQLDDAVHANDDLKENIAIVERRNNLLQAELE 1688
Cdd:TIGR00606  957 MKdienkIQDGKDDYLKQKETELNTVNAQLEECEKHQEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRENELKEVEEE 1036
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1689 ELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQTEVEEavQECRNAEEKAKKAITDAAMMA 1768
Cdd:TIGR00606 1037 LKQHLKEMGQMQVLQMKQEHQKLEENIDLIKRNHVLALGRQKGYEKEIKHFKKELRE--PQFRDAEEKYREMMIVMRTTE 1114

                   ....
gi 6754774    1769 EELK 1772
Cdd:TIGR00606 1115 LVNK 1118
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
1489-1926 2.42e-11

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 69.30  E-value: 2.42e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1489 AYEESLEHLETfkrenknLQEEISDLTEQLGEGGKNVHEL-EKIRKQLEvEKLELQSALEEAEASLEHEEGKILRAQLEF 1567
Cdd:PRK02224  245 EHEERREELET-------LEAEIEDLRETIAETEREREELaEEVRDLRE-RLEELEEERDDLLAEAGLDDADAEAVEARR 316
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1568 NQIKAEIErKLAEKDEEMEQAKRNHLRMVDSLQTSLDaETRSRNEALRVK-KKMEGDLNEMEIQLSQANRIASEAQKHLK 1646
Cdd:PRK02224  317 EELEDRDE-ELRDRLEECRVAAQAHNEEAESLREDAD-DLEERAEELREEaAELESELEEAREAVEDRREEIEELEEEIE 394
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1647 NSQAHLKDTQLQLDDAVHANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSR---KLAE--QElIETSERVQLLHSQ 1721
Cdd:PRK02224  395 ELRERFGDAPVDLGNAEDFLEELREERDELREREAELEATLRTARERVEEAEALLeagKCPEcgQP-VEGSPHVETIEED 473
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1722 NtsliNQKKKMESDLTQLQTEVEEAvqecrnaEEKAKKAitdaammaEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDE 1801
Cdd:PRK02224  474 R----ERVEELEAELEDLEEEVEEV-------EERLERA--------EDLVEAEDRIERLEERREDLEELIAERRETIEE 534
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1802 AEQialkggkkQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLMRLQDLVDKL-------- 1873
Cdd:PRK02224  535 KRE--------RAEELRERAAELEAEAEEKREAAAEAEEEAEEAREEVAELNSKLAELKERIESLERIRTLLaaiadaed 606
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....
gi 6754774   1874 QLKVKAYKRQA-EEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKS 1926
Cdd:PRK02224  607 EIERLREKREAlAELNDERRERLAEKRERKRELEAEFDEARIEEAREDKERAEE 660
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
1653-1938 2.76e-11

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 69.20  E-value: 2.76e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1653 KDTQLQLDDAvhanddlKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQ-----------ELIETSERVQLLHSQ 1721
Cdd:COG1196  175 EEAERKLEAT-------EENLERLEDILGELERQLEPLERQAEKAERYRELKEElkeleaellllKLRELEAELEELEAE 247
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1722 NTSLINQKKKMESDLTQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDE 1801
Cdd:COG1196  248 LEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAE 327
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1802 AEQiALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLMRLQDLVDKLQLKVKAYK 1881
Cdd:COG1196  328 LEE-ELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELE 406
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 6754774  1882 RQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDIGAKKMHDEE 1938
Cdd:COG1196  407 EAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLE 463
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
869-1211 4.63e-11

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 68.40  E-value: 4.63e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   869 EARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLiknkiqleAKVKEMTERLEDEEEMNAELTAKKRKLEde 948
Cdd:COG4913  609 RAKLAALEAELAELEEELAEAEERLEALEAELDALQERREAL--------QRLAEYSWDEIDVASAEREIAELEAELE-- 678
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   949 csELKKDIDDLEltlaKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKSKvk 1028
Cdd:COG4913  679 --RLDASSDDLA----ALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLELRAL-- 750
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1029 LEQQVDDLEGSlEQEKKVRMDLERAKRKLEGDLKLTQESIMDLendklqLEEKLKKKEFDISQQNSKIEDEQALALQLQK 1108
Cdd:COG4913  751 LEERFAAALGD-AVERELRENLEERIDALRARLNRAEEELERA------MRAFNREWPAETADLDADLESLPEYLALLDR 823
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1109 ----KLKENQARIEELEEeleaeRTARAKVEKLRSDLSRELEEISERLEEA---------GGATSVQIEMNKKREAEFQK 1175
Cdd:COG4913  824 leedGLPEYEERFKELLN-----ENSIEFVADLLSKLRRAIREIKERIDPLndslkripfGPGRYLRLEARPRPDPEVRE 898
                        330       340       350
                 ....*....|....*....|....*....|....*.
gi 6754774  1176 MRRDLEEATLQHEATAAALRKKHADSVAELGEQIDN 1211
Cdd:COG4913  899 FRQELRAVTSGASLFDEELSEARFAALKRLIERLRS 934
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1176-1804 7.57e-11

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 67.63  E-value: 7.57e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1176 MRRDLEEATLQHEATAAAlrKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDvtsnmEQIIKAKANLEKvsrtLE 1255
Cdd:COG4913  240 AHEALEDAREQIELLEPI--RELAERYAAARERLAELEYLRAALRLWFAQRRLELLE-----AELEELRAELAR----LE 308
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1256 DQANEYRVKLEEAQRSLNDFTTQRAKLQTEN-GELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHA 1334
Cdd:COG4913  309 AELERLEARLDALREELDELEAQIRGNGGDRlEQLEREIERLERELEERERRRARLEALLAALGLPLPASAEEFAALRAE 388
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1335 LQSSRHDCDLLREQYEEemeAKAELQRVLSKANSEVAQWRTkyETDAIQRT-----EELEEAKKKLAQRLQDAEEAVEAV 1409
Cdd:COG4913  389 AAALLEALEEELEALEE---ALAEAEAALRDLRRELRELEA--EIASLERRksnipARLLALRDALAEALGLDEAELPFV 463
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1410 nakCSSLE-KTKHRL-QNEIE--------DLMVDVERSNAAAAALDK---KQR-NFDKIlaewkqkyEESQSELESSQKE 1475
Cdd:COG4913  464 ---GELIEvRPEEERwRGAIErvlggfalTLLVPPEHYAAALRWVNRlhlRGRlVYERV--------RTGLPDPERPRLD 532
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1476 ARSLSTELFKLKNAYEESLEHLetfkrenknlqeeisdlteqlgeggknvhelekIRKQLEVEKLElqsaleeAEASLEH 1555
Cdd:COG4913  533 PDSLAGKLDFKPHPFRAWLEAE---------------------------------LGRRFDYVCVD-------SPEELRR 572
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1556 EEGKILRAqlefNQIKAEieRKLAEKDEEMEQAKRNHL-----RMVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQ 1630
Cdd:COG4913  573 HPRAITRA----GQVKGN--GTRHEKDDRRRIRSRYVLgfdnrAKLAALEAELAELEEELAEAEERLEALEAELDALQER 646
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1631 LSQANRIA--SEAQKHLKNSQAHLKDTQLQLDDAVHANDDLKEniaiverrnnlLQAELEELRAVVEQtersrklAEQEL 1708
Cdd:COG4913  647 REALQRLAeySWDEIDVASAEREIAELEAELERLDASSDDLAA-----------LEEQLEELEAELEE-------LEEEL 708
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1709 IETSERVQLLHSQNTSLinqkkkmESDLTQLQTEVEEAVQECRNAEEKAkkaitdaammAEELKKEQDTSAHLERMKKNM 1788
Cdd:COG4913  709 DELKGEIGRLEKELEQA-------EEELDELQDRLEAAEDLARLELRAL----------LEERFAAALGDAVERELRENL 771
                        650
                 ....*....|....*.
gi 6754774  1789 EQTIKDLQHRLDEAEQ 1804
Cdd:COG4913  772 EERIDALRARLNRAEE 787
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
846-1430 1.11e-10

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 67.25  E-value: 1.11e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   846 ETEKEMANMKEEFG---RVKDALEKSEARRKELE------EKMVSLLQEKNDLQ-----LQVQAEQDNLNDAEERCDQLI 911
Cdd:COG4913  222 DTFEAADALVEHFDdleRAHEALEDAREQIELLEpirelaERYAAARERLAELEylraaLRLWFAQRRLELLEAELEELR 301
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   912 KNKIQLEAKVKEMTERLEDEEEMNAELTAKKRKLE-DECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEI 990
Cdd:COG4913  302 AELARLEAELERLEARLDALREELDELEAQIRGNGgDRLEQLEREIERLERELEERERRRARLEALLAALGLPLPASAEE 381
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   991 IAKLTKEKKALQEAHQQALDDLQAEEDKvntLTKSKVKLEQQVDDLEG---SLEQeKKVRMD--LERAKRKLEGDLKLTQ 1065
Cdd:COG4913  382 FAALRAEAAALLEALEEELEALEEALAE---AEAALRDLRRELRELEAeiaSLER-RKSNIParLLALRDALAEALGLDE 457
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1066 ESI------MDLEN----------------------------------DKLQLEEKL---KKKEFDISQQNSKIeDEQAL 1102
Cdd:COG4913  458 AELpfvgelIEVRPeeerwrgaiervlggfaltllvppehyaaalrwvNRLHLRGRLvyeRVRTGLPDPERPRL-DPDSL 536
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1103 ALQLQkkLKENQARieELEEELEAERTARAKVEKLRsdlsrELEEISERLEEAGgatsvQIEMNKKReaeFQKMRRDLEE 1182
Cdd:COG4913  537 AGKLD--FKPHPFR--AWLEAELGRRFDYVCVDSPE-----ELRRHPRAITRAG-----QVKGNGTR---HEKDDRRRIR 599
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1183 AT--LQHEATA--AALRKKHA---DSVAELGEQIDNLQRVKQKLEKEKS------EFKLELDDVTSNMEQIIKAKANLEK 1249
Cdd:COG4913  600 SRyvLGFDNRAklAALEAELAeleEELAEAEERLEALEAELDALQERREalqrlaEYSWDEIDVASAEREIAELEAELER 679
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1250 VS------RTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEE 1323
Cdd:COG4913  680 LDassddlAALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLELRALLEERFAAAL 759
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1324 EGKAKNALAHALQSSRHDCDLLREQYEEEMEAKaeLQRVLSKANSEVAQWRTKYET----DAI---QRTEELEEAKKKLA 1396
Cdd:COG4913  760 GDAVERELRENLEERIDALRARLNRAEEELERA--MRAFNREWPAETADLDADLESlpeyLALldrLEEDGLPEYEERFK 837
                        650       660       670
                 ....*....|....*....|....*....|....
gi 6754774  1397 QRLQDAEEavEAVNAKCSSLEKTKHRLQNEIEDL 1430
Cdd:COG4913  838 ELLNENSI--EFVADLLSKLRRAIREIKERIDPL 869
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
846-1302 1.17e-10

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 66.99  E-value: 1.17e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    846 ETEKEMANMKEEFGRVKDALEKSEARRKELEEKMVSLLQEKNDLQLQVQA-------EQDNLNDAEERCDQLIKNKIQLE 918
Cdd:PRK02224  290 ELEEERDDLLAEAGLDDADAEAVEARREELEDRDEELRDRLEECRVAAQAhneeaesLREDADDLEERAEELREEAAELE 369
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    919 AKVKEMTERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAkltkEK 998
Cdd:PRK02224  370 SELEEAREAVEDRREEIEELEEEIEELRERFGDAPVDLGNAEDFLEELREERDELREREAELEATLRTARERVE----EA 445
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    999 KALQEA--------------HQQALDDlqaEEDKVNTLTKSKVKLEQQVDDLEGSLEQEKKVRmDLERAKRKLEGDLKLT 1064
Cdd:PRK02224  446 EALLEAgkcpecgqpvegspHVETIEE---DRERVEELEAELEDLEEEVEEVEERLERAEDLV-EAEDRIERLEERREDL 521
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1065 QESIMD----LENDKLQLEEKLKKKEfdisQQNSKIEDEQALALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSD 1140
Cdd:PRK02224  522 EELIAErretIEEKRERAEELRERAA----ELEAEAEEKREAAAEAEEEAEEAREEVAELNSKLAELKERIESLERIRTL 597
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1141 LSrELEEISERLEEAGGATSVQIEMNKKRE---AEFQKMRRDLEEATlqHEATAAALRKKHADSVAELGEQIDNLQRvkq 1217
Cdd:PRK02224  598 LA-AIADAEDEIERLREKREALAELNDERRerlAEKRERKRELEAEF--DEARIEEAREDKERAEEYLEQVEEKLDE--- 671
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1218 kLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYrvklEEAQRSLNDFTTQRAKLQTEN-GELARQLEEK 1296
Cdd:PRK02224  672 -LREERDDLQAEIGAVENELEELEELRERREALENRVEALEALY----DEAEELESMYGDLRAELRQRNvETLERMLNET 746

                  ....*.
gi 6754774   1297 EALISQ 1302
Cdd:PRK02224  747 FDLVYQ 752
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1200-1873 1.53e-10

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 66.48  E-value: 1.53e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1200 DSVAELGEQIDNLQRVKQKLEKEKSEFKLeLDDVTSNMEQIIKAKANLEKVsRTLEDQANEYRV--KLEEAQRSLNDFTT 1277
Cdd:COG4913  225 EAADALVEHFDDLERAHEALEDAREQIEL-LEPIRELAERYAAARERLAEL-EYLRAALRLWFAqrRLELLEAELEELRA 302
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1278 QRAKLQTENGELARQLEEKEALISQLTRGKL-SYTQQMEDLKRQLEEEGKAKNALAHALQSSRHDCDLLREQYEEEMEAK 1356
Cdd:COG4913  303 ELARLEAELERLEARLDALREELDELEAQIRgNGGDRLEQLEREIERLERELEERERRRARLEALLAALGLPLPASAEEF 382
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1357 AELQRVLSKANSEVAQWRTKYE---TDAIQRTEELEEAKKKLAQRLQDAE--------EAVEAVNAKCSSLEKTKHRL-- 1423
Cdd:COG4913  383 AALRAEAAALLEALEEELEALEealAEAEAALRDLRRELRELEAEIASLErrksnipaRLLALRDALAEALGLDEAELpf 462
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1424 --------------QNEIE--------DLMVDVERSNAAAAALDK---KQR-NFDKIlaewkqkyEESQSELESSQKEAR 1477
Cdd:COG4913  463 vgelievrpeeerwRGAIErvlggfalTLLVPPEHYAAALRWVNRlhlRGRlVYERV--------RTGLPDPERPRLDPD 534
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1478 SLSTELFKLKNAYEESLEHL-------------ETFKRENKNLQEE--ISD------------LTEQLGEGGKN---VHE 1527
Cdd:COG4913  535 SLAGKLDFKPHPFRAWLEAElgrrfdyvcvdspEELRRHPRAITRAgqVKGngtrhekddrrrIRSRYVLGFDNrakLAA 614
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1528 LEKIRKQLEVEKLELQSALEEAEASLEHEEGKILR----AQLEFNQIK-AEIERKLAEKDEEMEQAKRNHLRmVDSLQTS 1602
Cdd:COG4913  615 LEAELAELEEELAEAEERLEALEAELDALQERREAlqrlAEYSWDEIDvASAEREIAELEAELERLDASSDD-LAALEEQ 693
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1603 LDAetrsrnealrvkkkMEGDLNEMEIQLSQANRIASEAQKHLKNSQAHLKDTQLQLDDAvhanddlkeniaiVERRNNL 1682
Cdd:COG4913  694 LEE--------------LEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAA-------------EDLARLE 746
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1683 LQAELEELRAVVEQTERSRKLAEQelietservqllhsqntsLINQKKKMESDLTQLQTEVEEAVQE-CRNAEEKAKKAI 1761
Cdd:COG4913  747 LRALLEERFAAALGDAVERELREN------------------LEERIDALRARLNRAEEELERAMRAfNREWPAETADLD 808
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1762 TDAAMMAEELK-----KEQDTSAHLERMK----KNMEQTIKDLQHRLDEAEQIAlkggKKQLQKLEARVRELE-NE---- 1827
Cdd:COG4913  809 ADLESLPEYLAlldrlEEDGLPEYEERFKellnENSIEFVADLLSKLRRAIREI----KERIDPLNDSLKRIPfGPgryl 884
                        730       740       750       760
                 ....*....|....*....|....*....|....*....|....*....
gi 6754774  1828 -LEAEQKRNAEsVKGMRKSERRIKELTYQTEED--KKNLMRLQDLVDKL 1873
Cdd:COG4913  885 rLEARPRPDPE-VREFRQELRAVTSGASLFDEElsEARFAALKRLIERL 932
PTZ00121 PTZ00121
MAEBL; Provisional
837-1286 1.64e-10

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 66.70  E-value: 1.64e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    837 KIKPLLKSAETEKEMANMKEEFGRVKDALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKIQ 916
Cdd:PTZ00121 1523 KADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYE 1602
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    917 LEAKVKEMTERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHatENKVKnlTEEMAGLDEIIAKLTK 996
Cdd:PTZ00121 1603 EEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEE--ENKIK--AAEEAKKAEEDKKKAE 1678
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    997 EKKALQEAHQQALDDLQAEEDKVNTLTKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQEsimdlendkL 1076
Cdd:PTZ00121 1679 EAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEE---------A 1749
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1077 QLEEKLKKKefdiSQQNSKIEDEQALALQlqkklKENQARIEELEEELEAERtaRAKVEKLRSDLSRELEEISERLEEAG 1156
Cdd:PTZ00121 1750 KKDEEEKKK----IAHLKKEEEKKAEEIR-----KEKEAVIEEELDEEDEKR--RMEVDKKIKDIFDNFANIIEGGKEGN 1818
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1157 GATSVQIEM---NKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDV 1233
Cdd:PTZ00121 1819 LVINDSKEMedsAIKEVADSKNMQLEEADAFEKHKFNKNNENGEDGNKEADFNKEKDLKEDDEEEIEEADEIEKIDKDDI 1898
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6754774   1234 TS---------NMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTEN 1286
Cdd:PTZ00121 1899 EReipnnnmagKNNDIIDDKLDKDEYIKRDAEETREEIIKISKKDMCINDFSSKFCDYMKDN 1960
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
849-1428 2.35e-10

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 65.81  E-value: 2.35e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     849 KEMANMKEEFGRVKDALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKIQLEAKVKEMTERL 928
Cdd:TIGR04523  103 SDLSKINSEIKNDKEQKNKLEVELNKLEKQKKENKKNIDKFLTEIKKKEKELEKLNNKYNDLKKQKEELENELNLLEKEK 182
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     929 EDEEEMNAELTAKKRKLEDECSELKKDIDD---LELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAH 1005
Cdd:TIGR04523  183 LNIQKNIDKIKNKLLKLELLLSNLKKKIQKnksLESQISELKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQ 262
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1006 QQALDDLQAEEDKVNTLTKSKVKLEQQVDDLEGSLEQEKKVRMdlERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKK 1085
Cdd:TIGR04523  263 NKIKKQLSEKQKELEQNNKKIKELEKQLNQLKSEISDLNNQKE--QDWNKELKSELKNQEKKLEEIQNQISQNNKIISQL 340
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1086 EFDISQQNSKIEDEQALALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEiserleeaggatsvQIEM 1165
Cdd:TIGR04523  341 NEQISQLKKELTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQN--------------QEKL 406
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1166 NKKREAEFQKMRRDLEEATLQHEaTAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSnmeQIIKAKA 1245
Cdd:TIGR04523  407 NQQKDEQIKKLQQEKELLEKEIE-RLKETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESLETQLKVLSR---SINKIKQ 482
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1246 NLEKVSRTLEDQANEyrvkleeaqrsLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEE-- 1323
Cdd:TIGR04523  483 NLEQKQKELKSKEKE-----------LKKLNEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEKESKISDLEDELNKdd 551
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1324 EGKAKNALAHALQSSRHDCDLLREQYEEEMEAKAELQRVLSKANSEVaqwrtkyeTDAIQRTEELEEAKKKLAQRLQDAE 1403
Cdd:TIGR04523  552 FELKKENLEKEIDEKNKEIEELKQTQKSLKKKQEEKQELIDQKEKEK--------KDLIKEIEEKEKKISSLEKELEKAK 623
                          570       580
                   ....*....|....*....|....*
gi 6754774    1404 EAVEAVNAKCSSLEKTKHRLQNEIE 1428
Cdd:TIGR04523  624 KENEKLSSIIKNIKSKKNKLKQEVK 648
PTZ00121 PTZ00121
MAEBL; Provisional
1273-1938 2.44e-10

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 66.32  E-value: 2.44e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1273 NDFTTQRAKLQTENGELARQLEEKEaliSQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSSRHDCDLLREQYEEE 1352
Cdd:PTZ00121 1079 FDFDAKEDNRADEATEEAFGKAEEA---KKTETGKAEEARKAEEAKKKAEDARKAEEARKAEDARKAEEARKAEDAKRVE 1155
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1353 MEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKcsslEKTKHRLQNEIEDLM- 1431
Cdd:PTZ00121 1156 IARKAEDARKAEEARKAEDAKKAEAARKAEEVRKAEELRKAEDARKAEAARKAEEERKAE----EARKAEDAKKAEAVKk 1231
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1432 VDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLknayEESLEHLETFKRENKNLQEEI 1511
Cdd:PTZ00121 1232 AEEAKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKA----EEKKKADEAKKAEEKKKADEA 1307
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1512 SDLTEQLGEGGKNVHELEKIRKQLEVEKLELQSALEEAEASLEHEEGKILRAQlefnqiKAEIERKLAEKDEEMEQAKRN 1591
Cdd:PTZ00121 1308 KKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAE------AAEEKAEAAEKKKEEAKKKAD 1381
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1592 HLRMvdslqtslDAETRSRNEALRvKKKMEGDLNEMEIQLSQANRIASEAQKHLKNSQAHLKDTQLQLDDAVHAnDDLKE 1671
Cdd:PTZ00121 1382 AAKK--------KAEEKKKADEAK-KKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKA-DEAKK 1451
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1672 NIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESdltQLQTEVEEAVQECR 1751
Cdd:PTZ00121 1452 KAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADE---AKKAEEAKKADEAK 1528
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1752 NAEEKAKkaiTDAAMMAEELKKEQDTSaHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVREL------E 1825
Cdd:PTZ00121 1529 KAEEAKK---ADEAKKAEEKKKADELK-KAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVmklyeeE 1604
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1826 NELEAEQKRNAESVKG----MRKSE---RRIKELTYQTEEDKKNLMRLQDLVDKLQLKVKAYKRQAEEAEEQAntnlSKF 1898
Cdd:PTZ00121 1605 KKMKAEEAKKAEEAKIkaeeLKKAEeekKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKA----EEA 1680
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|
gi 6754774   1899 RKVQHELDEAEERADIAESQVNKLRAKSRDIGAKKMHDEE 1938
Cdd:PTZ00121 1681 KKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEE 1720
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
856-1335 2.59e-10

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 65.97  E-value: 2.59e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     856 EEFGRVKDALEKSEAR-RKELEEKMVSL---------LQEKNDLQLQVQAEQDNLND--AEERcDQLIKNKIQLEAKVKE 923
Cdd:pfam01576  562 EEKAAAYDKLEKTKNRlQQELDDLLVDLdhqrqlvsnLEKKQKKFDQMLAEEKAISAryAEER-DRAEAEAREKETRALS 640
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     924 MTERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGL-DEIIAklTKEKKALQ 1002
Cdd:pfam01576  641 LARALEEALEAKEELERTNKQLRAEMEDLVSSKDDVGKNVHELERSKRALEQQVEEMKTQLEELeDELQA--TEDAKLRL 718
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1003 EAHQQALD-----DLQAEEDKVNTLTKSKVKleqQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQ 1077
Cdd:pfam01576  719 EVNMQALKaqferDLQARDEQGEEKRRQLVK---QVRELEAELEDERKQRAQAVAAKKKLELDLKELEAQIDAANKGREE 795
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1078 LEEKLKKKEFDISQQNSKIEDEQALALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGG 1157
Cdd:pfam01576  796 AVKQLKKLQAQMKDLQRELEEARASRDEILAQSKESEKKLKNLEAELLQLQEDLAASERARRQAQQERDELADEIASGAS 875
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1158 ATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRK--KHADSV-AELGEQIDNLQRV---KQKLEKEKSEFKLELD 1231
Cdd:pfam01576  876 GKSALQDEKRRLEARIAQLEEELEEEQSNTELLNDRLRKstLQVEQLtTELAAERSTSQKSesaRQQLERQNKELKAKLQ 955
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1232 DVTS----------------------NMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGEL 1289
Cdd:pfam01576  956 EMEGtvkskfkssiaaleakiaqleeQLEQESRERQAANKLVRRTEKKLKEVLLQVEDERRHADQYKDQAEKGNSRMKQL 1035
                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*.
gi 6754774    1290 ARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHAL 1335
Cdd:pfam01576 1036 KRQLEEAEEEASRANAARRKLQRELDDATESNESMNREVSTLKSKL 1081
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
846-1112 3.17e-10

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 65.43  E-value: 3.17e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     846 ETEKEMANMKEEFGRVKDALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKIQLEAKVKEMT 925
Cdd:TIGR04523  367 EKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSEIKDLT 446
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     926 ERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEah 1005
Cdd:TIGR04523  447 NQDSVKELIIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQKELKSKEKELKKLNEEKKELEEKVKDLTKKISSLKE-- 524
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1006 qqalddlqaeedKVNTLTKSKVKLEQQVDDLEGSLEQEK--KVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLK 1083
Cdd:TIGR04523  525 ------------KIEKLESEKKEKESKISDLEDELNKDDfeLKKENLEKEIDEKNKEIEELKQTQKSLKKKQEEKQELID 592
                          250       260
                   ....*....|....*....|....*....
gi 6754774    1084 KKEFDISQQNSKIEDEQALALQLQKKLKE 1112
Cdd:TIGR04523  593 QKEKEKKDLIKEIEEKEKKISSLEKELEK 621
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
1479-1925 5.42e-10

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 64.66  E-value: 5.42e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1479 LSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKIRKQLEVEKLELQSALEEA---EASLEH 1555
Cdd:TIGR04523  122 LEVELNKLEKQKKENKKNIDKFLTEIKKKEKELEKLNNKYNDLKKQKEELENELNLLEKEKLNIQKNIDKIknkLLKLEL 201
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1556 ---------EEGKILRAQL-----EFNQIKAEIERKLAEKDEEMEQAKRNHLRMVDSLQ------TSLDAETRSRNEALR 1615
Cdd:TIGR04523  202 llsnlkkkiQKNKSLESQIselkkQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDeqnkikKQLSEKQKELEQNNK 281
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1616 VKKKMEGDLNEMEIQLSQANR-----IASEAQKHLKNSQAHLKDTQLQLDDAVHANDDLKENIAIVERRNNLLQAELEEL 1690
Cdd:TIGR04523  282 KIKELEKQLNQLKSEISDLNNqkeqdWNKELKSELKNQEKKLEEIQNQISQNNKIISQLNEQISQLKKELTNSESENSEK 361
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1691 RAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEE 1770
Cdd:TIGR04523  362 QRELEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSE 441
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1771 LKKEQDTSAHLERMKKNMEQTIKDLQHRLD-------------EAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAE 1837
Cdd:TIGR04523  442 IKDLTNQDSVKELIIKNLDNTRESLETQLKvlsrsinkikqnlEQKQKELKSKEKELKKLNEEKKELEEKVKDLTKKISS 521
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1838 SVKGMRKSERRIKELTYQTEEDKKNLMRLQDLVDKLQL-KVKAYKRQAEEAEEQANTNLSKfrkvqhELDEAEERADIAE 1916
Cdd:TIGR04523  522 LKEKIEKLESEKKEKESKISDLEDELNKDDFELKKENLeKEIDEKNKEIEELKQTQKSLKK------KQEEKQELIDQKE 595

                   ....*....
gi 6754774    1917 SQVNKLRAK 1925
Cdd:TIGR04523  596 KEKKDLIKE 604
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
849-1257 7.62e-10

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 64.02  E-value: 7.62e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   849 KEMANMKEEFGRVKDALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQD--NLNDAEERCDQLIKNKIQLEAKVKEMTE 926
Cdd:COG4717   81 KEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQLLPLyqELEALEAELAELPERLEELEERLEELRE 160
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   927 RLEDEEEMNAELTAKKRKLEDEC-----------SELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLT 995
Cdd:COG4717  161 LEEELEELEAELAELQEELEELLeqlslateeelQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAA 240
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   996 KEKKALQE-----------AHQQALDDLQAEEDKV---------------NTLTKSKVKLEQQVDDLEGSLEQEKKVRMD 1049
Cdd:COG4717  241 LEERLKEArlllliaaallALLGLGGSLLSLILTIagvlflvlgllallfLLLAREKASLGKEAEELQALPALEELEEEE 320
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1050 LERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEfdisqqnskiedEQALALQLQKKLKENQARIEELEEELEAERT 1129
Cdd:COG4717  321 LEELLAALGLPPDLSPEELLELLDRIEELQELLREAE------------ELEEELQLEELEQEIAALLAEAGVEDEEELR 388
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1130 ARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKR--EAEFQKMRRDLEEATLQHEataaALRKKHADSVAELG- 1206
Cdd:COG4717  389 AALEQAEEYQELKEELEELEEQLEELLGELEELLEALDEEelEEELEELEEELEELEEELE----ELREELAELEAELEq 464
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|..
gi 6754774  1207 -EQIDNLQRVKQKLEKEKSEFKLELDDVTSNMeqiiKAKANLEKVSRTLEDQ 1257
Cdd:COG4717  465 lEEDGELAELLQELEELKAELRELAEEWAALK----LALELLEEAREEYREE 512
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
916-1359 8.95e-10

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 63.38  E-value: 8.95e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     916 QLEAKVKEMTERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLT 995
Cdd:pfam07888   35 RLEECLQERAELLQAQEAANRQREKEKERYKRDREQWERQRRELESRVAELKEELRQSREKHEELEEKYKELSASSEELS 114
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     996 KEKKALQEAHQQALDDLQAEEDKVNTLTKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDK 1075
Cdd:pfam07888  115 EEKDALLAQRAAHEARIRELEEDIKTLTQRVLERETELERMKERAKKAGAQRKEEEAERKQLQAKLQQTEEELRSLSKEF 194
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1076 LQLEEKLKKKEFDISQQNSKIEDEQALALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSreleeiserleEA 1155
Cdd:pfam07888  195 QELRNSLAQRDTQVLQLQDTITTLTQKLTTAHRKEAENEALLEELRSLQERLNASERKVEGLGEELS-----------SM 263
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1156 GGATSvqiemnkKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEF-KLElddvt 1234
Cdd:pfam07888  264 AAQRD-------RTQAELHQARLQAAQLTLQLADASLALREGRARWAQERETLQQSAEADKDRIEKLSAELqRLE----- 331
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1235 snmEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLndfTTQRAKLQTENGELARQLEEKEALisqltrgkLSYTQQM 1314
Cdd:pfam07888  332 ---ERLQEERMEREKLEVELGREKDCNRVQLSESRREL---QELKASLRVAQKEKEQLQAEKQEL--------LEYIRQL 397
                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*..
gi 6754774    1315 EdlkRQLEEEGKAKNALAHALQSSRHDCDLL--REQYEEEMEAKAEL 1359
Cdd:pfam07888  398 E---QRLETVADAKWSEAALTSTERPDSPLSdsEDENPEALQPPRPL 441
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
1346-1937 1.54e-09

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 63.55  E-value: 1.54e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1346 REQYEEEMEAKAELQRVLSKANSEVAQWRTKYET----DAIQRteELEEAK-KKLAQRLQDAEEAVEAVNAKCSSLEKTK 1420
Cdd:TIGR02169  176 LEELEEVEENIERLDLIIDEKRQQLERLRREREKaeryQALLK--EKREYEgYELLKEKEALERQKEAIERQLASLEEEL 253
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1421 HRLQNEIEDLmvdVERSNAAAAALDKKQRNFDKILAEwkqkyeesqsELESSQKEARSLSTELFKLKNAYEESLEHLETF 1500
Cdd:TIGR02169  254 EKLTEEISEL---EKRLEEIEQLLEELNKKIKDLGEE----------EQLRVKEKIGELEAEIASLERSIAEKERELEDA 320
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1501 KRENKNLQEEISDLTEQLGEGGKNVHELEKIRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIErklaE 1580
Cdd:TIGR02169  321 EERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETRDELKDYREKLE----K 396
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1581 KDEEMEQAKRNHLRMVDSLQtSLDAETRSRNEALrvkKKMEGDLNEMEIQLSqanriasEAQKHLKNSQAHLKDTQLQLD 1660
Cdd:TIGR02169  397 LKREINELKRELDRLQEELQ-RLSEELADLNAAI---AGIEAKINELEEEKE-------DKALEIKKQEWKLEQLAADLS 465
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1661 DAVHANDDLKENIAIVERRNNLLQAELEELRA---VVEQTERSRKLAEQELietSERVQLLHSQNTSLINQKKkmesdlt 1737
Cdd:TIGR02169  466 KYEQELYDLKEEYDRVEKELSKLQRELAEAEAqarASEERVRGGRAVEEVL---KASIQGVHGTVAQLGSVGE------- 535
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1738 QLQTEVEEAVQECRNA-----EEKAKKAITDAA------MMAEELKKEQDTSAHLERMKKN------------------- 1787
Cdd:TIGR02169  536 RYATAIEVAAGNRLNNvvvedDAVAKEAIELLKrrkagrATFLPLNKMRDERRDLSILSEDgvigfavdlvefdpkyepa 615
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1788 MEQTIKD--LQHRLDEAEQI------------------ALKGG--------------KKQLQKLEARVRELENELEAEQK 1833
Cdd:TIGR02169  616 FKYVFGDtlVVEDIEAARRLmgkyrmvtlegelfeksgAMTGGsraprggilfsrsePAELQRLRERLEGLKRELSSLQS 695
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1834 RNAESVKGMRKSERRIKELTYQTEEDKKNLMRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERAD 1913
Cdd:TIGR02169  696 ELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEARIEELEEDLH 775
                          650       660
                   ....*....|....*....|....
gi 6754774    1914 IAESQVNKLRAKSRDIGAKKMHDE 1937
Cdd:TIGR02169  776 KLEEALNDLEARLSHSRIPEIQAE 799
PTZ00121 PTZ00121
MAEBL; Provisional
837-1329 1.73e-09

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 63.24  E-value: 1.73e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    837 KIKPLLKSAETEKEMANMK---EEFGRVKDALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQ----DNLNDAEE--RC 907
Cdd:PTZ00121 1445 KADEAKKKAEEAKKAEEAKkkaEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAkkkaDEAKKAEEakKA 1524
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    908 DQLIKNKIQLEAKVKEMTERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVknltEEMAGL 987
Cdd:PTZ00121 1525 DEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARI----EEVMKL 1600
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    988 DEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDlKLTQES 1067
Cdd:PTZ00121 1601 YEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEED-KKKAEE 1679
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1068 IMDLENDKLQLEEKLKKKEFD---ISQQNSKIEDEQALALQLQKKLKENqarieeleeeleaertaRAKVEKLRsdlsRE 1144
Cdd:PTZ00121 1680 AKKAEEDEKKAAEALKKEAEEakkAEELKKKEAEEKKKAEELKKAEEEN-----------------KIKAEEAK----KE 1738
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1145 LEEISERLEEAggatsvqiemnKKREAEFQKMRRDLEEatlqhEATAAALRKKHADSVAELGeqidnlqrVKQKLEKEKS 1224
Cdd:PTZ00121 1739 AEEDKKKAEEA-----------KKDEEEKKKIAHLKKE-----EEKKAEEIRKEKEAVIEEE--------LDEEDEKRRM 1794
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1225 EFKLELDDVTSNMEQIIK-----------AKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQL 1293
Cdd:PTZ00121 1795 EVDKKIKDIFDNFANIIEggkegnlvindSKEMEDSAIKEVADSKNMQLEEADAFEKHKFNKNNENGEDGNKEADFNKEK 1874
                         490       500       510
                  ....*....|....*....|....*....|....*.
gi 6754774   1294 EEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKN 1329
Cdd:PTZ00121 1875 DLKEDDEEEIEEADEIEKIDKDDIEREIPNNNMAGK 1910
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1475-1920 1.78e-09

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 63.01  E-value: 1.78e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1475 EARSLSTELFKLKNAYEESLEhletfKRENKNLQEEISDLTEQLGEGGKNVHELEKIRKQLEVEKLELQSALEEAEasLE 1554
Cdd:COG4913  226 AADALVEHFDDLERAHEALED-----AREQIELLEPIRELAERYAAARERLAELEYLRAALRLWFAQRRLELLEAE--LE 298
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1555 HEEGKILRAQLEFNQIKAEIERkLAEKDEEMEQAKRNH-LRMVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSQ 1633
Cdd:COG4913  299 ELRAELARLEAELERLEARLDA-LREELDELEAQIRGNgGDRLEQLEREIERLERELEERERRRARLEALLAALGLPLPA 377
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1634 A----NRIASEAQKHLKNSQAHLKDTQLQLDDAV-------HANDDLKENIAIVERRNNLLQAELEELRAVVEqteRSRK 1702
Cdd:COG4913  378 SaeefAALRAEAAALLEALEEELEALEEALAEAEaalrdlrRELRELEAEIASLERRKSNIPARLLALRDALA---EALG 454
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1703 LAEQ------ELIETS----------ERVqlLHSQNTSL-------------INQKK----------------------- 1730
Cdd:COG4913  455 LDEAelpfvgELIEVRpeeerwrgaiERV--LGGFALTLlvppehyaaalrwVNRLHlrgrlvyervrtglpdperprld 532
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1731 ------KMESDLTQLQTEVEEAVQE------CRNAEE--KAKKAITDAAMMAEELKK-EQDTSAHLER---MKKNMEQTI 1792
Cdd:COG4913  533 pdslagKLDFKPHPFRAWLEAELGRrfdyvcVDSPEElrRHPRAITRAGQVKGNGTRhEKDDRRRIRSryvLGFDNRAKL 612
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1793 KDLQHRLDEAEQiALKGGKKQLQKLEARVRELENELEAEQK--RNAESVKGMRKSERRIKELtyqtEEDKKNLMRLQDLV 1870
Cdd:COG4913  613 AALEAELAELEE-ELAEAEERLEALEAELDALQERREALQRlaEYSWDEIDVASAEREIAEL----EAELERLDASSDDL 687
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|
gi 6754774  1871 DKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVN 1920
Cdd:COG4913  688 AALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLE 737
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
916-1142 3.83e-09

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 60.93  E-value: 3.83e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   916 QLEAKVKEMTERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLT 995
Cdd:COG4942   24 EAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQK 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   996 KEKK----ALQEAHQQALDDLQAEEDKVNTLTKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDL 1071
Cdd:COG4942  104 EELAellrALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELEALLAEL 183
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6754774  1072 ENDKLQLEEKLKKKEFDISQQNSKIEDEQALALQLQKKLKENQARIEE--LEEELEAERTARAKVEKLRSDLS 1142
Cdd:COG4942  184 EEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARleAEAAAAAERTPAAGFAALKGKLP 256
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
1182-1840 4.97e-09

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 61.66  E-value: 4.97e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1182 EATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDvtsNMEQIIKAKANLEKVSRTLEDQANEY 1261
Cdd:pfam05483  169 EKTKKYEYEREETRQVYMDLNNNIEKMILAFEELRVQAENARLEMHFKLKE---DHEKIQHLEEEYKKEINDKEKQVSLL 245
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1262 RVKLEEAQRSLNDFTTqrakLQTENGELARQLEEKEAL----ISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQS 1337
Cdd:pfam05483  246 LIQITEKENKMKDLTF----LLEESRDKANQLEEKTKLqdenLKELIEKKDHLTKELEDIKMSLQRSMSTQKALEEDLQI 321
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1338 SRHDCDLLREQYEEEMEAkaelqrvLSKANSEVAQWRTKYETDaiqrTEELEEAKKKLAQRLQDAEEAVEAV----NAKC 1413
Cdd:pfam05483  322 ATKTICQLTEEKEAQMEE-------LNKAKAAHSFVVTEFEAT----TCSLEELLRTEQQRLEKNEDQLKIItmelQKKS 390
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1414 SSLEKTKhRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEES 1493
Cdd:pfam05483  391 SELEEMT-KFKNNKEVELEELKKILAEDEKLLDEKKQFEKIAEELKGKEQELIFLLQAREKEIHDLEIQLTAIKTSEEHY 469
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1494 LEhletfkrenknlqeeisdlteqlgeggknvhELEKIRKQLEVEKLElqsaleeaEASLEHEEGKILRAQLEFNQIKAE 1573
Cdd:pfam05483  470 LK-------------------------------EVEDLKTELEKEKLK--------NIELTAHCDKLLLENKELTQEASD 510
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1574 IERKLAEKDEEMEQAKRNHLRMVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSQANRIASEAQKHLKNSQAHLK 1653
Cdd:pfam05483  511 MTLELKKHQEDIINCKKQEERMLKQIENLEEKEMNLRDELESVREEFIQKGDEVKCKLDKSEENARSIEYEVLKKEKQMK 590
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1654 DTQLQLDDAVHANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKME 1733
Cdd:pfam05483  591 ILENKCNNLKKQIENKNKNIEELHQENKALKKKGSAENKQLNAYEIKVNKLELELASAKQKFEEIIDNYQKEIEDKKISE 670
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1734 SDL----TQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKG 1809
Cdd:pfam05483  671 EKLleevEKAKAIADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSELGLYKNKEQEQSSAKAALEIELSN 750
                          650       660       670
                   ....*....|....*....|....*....|....
gi 6754774    1810 GKKQLQKLEARV---RELENELEAEQKRNAESVK 1840
Cdd:pfam05483  751 IKAELLSLKKQLeieKEEKEKLKMEAKENTAILK 784
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1100-1339 5.03e-09

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 60.55  E-value: 5.03e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1100 QALALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAggatsvqiemnkkrEAEFQKMRRD 1179
Cdd:COG4942   19 ADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRAL--------------EQELAALEAE 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1180 LEEATLQheatAAALRKKHADSVAELGEQIDNLQRVKQKlekekSEFKLELDdvTSNMEQIIKAKANLEKVSRTLEDQAN 1259
Cdd:COG4942   85 LAELEKE----IAELRAELEAQKEELAELLRALYRLGRQ-----PPLALLLS--PEDFLDAVRRLQYLKYLAPARREQAE 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1260 EYRVKLEEAQRSLNDFTTQRAKL-------QTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALA 1332
Cdd:COG4942  154 ELRADLAELAALRAELEAERAELeallaelEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLE 233

                 ....*..
gi 6754774  1333 HALQSSR 1339
Cdd:COG4942  234 AEAAAAA 240
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
898-1837 1.10e-08

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 60.84  E-value: 1.10e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     898 DNLNDAEERCDQLIKNKiqleAKVKEMTERLEDEEEMNAELTAKKRKLEDECSELKKdiddlelTLAKVEKEKHATENKV 977
Cdd:TIGR01612  769 NKINDYAKEKDELNKYK----SKISEIKNHYNDQINIDNIKDEDAKQNYDKSKEYIK-------TISIKEDEIFKIINEM 837
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     978 KNLTEE-MAGLDEIIAKLTKEKKALQEAHQQ---ALDDLQAE--EDKVNTLTKSKVKLEQQVDDLEGSLEQEKKVRMDLe 1051
Cdd:TIGR01612  838 KFMKDDfLNKVDKFINFENNCKEKIDSEHEQfaeLTNKIKAEisDDKLNDYEKKFNDSKSLINEINKSIEEEYQNINTL- 916
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1052 rakRKLEGDLKL---TQESIMDLENDKLQLEEKLKKK----------------EFDISQQNSKIEDEQALA--------- 1103
Cdd:TIGR01612  917 ---KKVDEYIKIcenTKESIEKFHNKQNILKEILNKNidtikesnlieksykdKFDNTLIDKINELDKAFKdaslndyea 993
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1104 -----LQLQKKLKENQARIEELEEELEAERTARA------KVEKLRSDLSR-------ELEEISERLEEAGGATSVQIEM 1165
Cdd:TIGR01612  994 knnelIKYFNDLKANLGKNKENMLYHQFDEKEKAtndieqKIEDANKNIPNieiaihtSIYNIIDEIEKEIGKNIELLNK 1073
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1166 NKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKlELDDVTSNMEQIIKAKA 1245
Cdd:TIGR01612 1074 EILEEAEINITNFNEIKEKLKHYNFDDFGKEENIKYADEINKIKDDIKNLDQKIDHHIKALE-EIKKKSENYIDEIKAQI 1152
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1246 N-LEKVSRTLedQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGK---LSYTQQMEDL-KRQ 1320
Cdd:TIGR01612 1153 NdLEDVADKA--ISNDDPEEIEKKIENIVTKIDKKKNIYDEIKKLLNEIAEIEKDKTSLEEVKginLSYGKNLGKLfLEK 1230
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1321 LEEEGKAKNALAHALQSSRHDCDLLREQYEE-------EMEAKAELQrVLSKANSEvaqwRTKYETDAIQRTEELEEAKK 1393
Cdd:TIGR01612 1231 IDEEKKKSEHMIKAMEAYIEDLDEIKEKSPEienemgiEMDIKAEME-TFNISHDD----DKDHHIISKKHDENISDIRE 1305
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1394 KLAQRLQDaeeaveavNAKCSSLEKTKHRLQNEIedlmVDVERSNAAAAALDKKQRNFDKILaewkqkyeesqselessq 1473
Cdd:TIGR01612 1306 KSLKIIED--------FSEESDINDIKKELQKNL----LDAQKHNSDINLYLNEIANIYNIL------------------ 1355
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1474 kearslstELFKLKNAYEESLEHLETFKRENKNLQEEISDlTEQLGEGGKNVHELEKIRKQLEveklelqSALEEAEASL 1553
Cdd:TIGR01612 1356 --------KLNKIKKIIDEVKEYTKEIEENNKNIKDELDK-SEKLIKKIKDDINLEECKSKIE-------STLDDKDIDE 1419
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1554 EHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRMVDSlqtslDAETRSRNEALRVKKKMEGDLNEMEIQLSQ 1633
Cdd:TIGR01612 1420 CIKKIKELKNHILSEESNIDTYFKNADENNENVLLLFKNIEMADN-----KSQHILKIKKDNATNDHDFNINELKEHIDK 1494
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1634 ANRIASEAQKHLKNSQAH-LKDTQLQLDDAVHAND----DLKENIAIVERRNNLLQAELEELRAVV----EQTERSRKLA 1704
Cdd:TIGR01612 1495 SKGCKDEADKNAKAIEKNkELFEQYKKDVTELLNKysalAIKNKFAKTKKDSEIIIKEIKDAHKKFileaEKSEQKIKEI 1574
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1705 EQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQ--TEVEEAVQECRNAEEKAKKAITDAAMMAEE--LKKEQDTSAH 1780
Cdd:TIGR01612 1575 KKEKFRIEDDAAKNDKSNKAAIDIQLSLENFENKFLkiSDIKKKINDCLKETESIEKKISSFSIDSQDteLKENGDNLNS 1654
                          970       980       990      1000      1010
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 6754774    1781 LERMKKNMEQTIKDLQHRldeaeqialkggKKQLQKLEARVRELENELEaEQKRNAE 1837
Cdd:TIGR01612 1655 LQEFLESLKDQKKNIEDK------------KKELDELDSEIEKIEIDVD-QHKKNYE 1698
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1671-1899 1.62e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 59.01  E-value: 1.62e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1671 ENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQTEVEEAVQEC 1750
Cdd:COG4942   20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAEL 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1751 RNAEEKAKKAITDAAMMAE----ELKKEQDTSAHLERMKKNMEQTIKDLQHRLDE--AEQIALKGGKKQLQKLEARVREL 1824
Cdd:COG4942  100 EAQKEELAELLRALYRLGRqpplALLLSPEDFLDAVRRLQYLKYLAPARREQAEElrADLAELAALRAELEAERAELEAL 179
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6754774  1825 ENELEAEQKR----NAESVKGMRKSERRIKELTYQTEEDKKNLMRLQDLVDKLQlkvkayKRQAEEAEEQANTNLSKFR 1899
Cdd:COG4942  180 LAELEEERAAlealKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLE------AEAAAAAERTPAAGFAALK 252
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1065-1292 1.68e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 59.01  E-value: 1.68e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1065 QESIMDLENDKLQLEEKLKKKEFDISQQNSKIEDEQALALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRE 1144
Cdd:COG4942   19 ADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAE 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1145 LEEISERLEE-------AGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRkkhadsvaelgEQIDNLQRVKQ 1217
Cdd:COG4942   99 LEAQKEELAEllralyrLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELR-----------ADLAELAALRA 167
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6754774  1218 KLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQ 1292
Cdd:COG4942  168 ELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAER 242
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
1075-1755 1.76e-08

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 59.74  E-value: 1.76e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1075 KLQLEEKLKKKEFDIsQQNSKIEDEQALALQ------------LQKKLKENQARIeeleeelEAERTARAKVEKLRSDLS 1142
Cdd:pfam05483   94 KVSIEAELKQKENKL-QENRKIIEAQRKAIQelqfenekvslkLEEEIQENKDLI-------KENNATRHLCNLLKETCA 165
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1143 RELEEISERLEEAGGATSVQIEMNKKREaefqKMRRDLEEATLQHEATAAALRKKhadsvaelgeqidnLQRVKQKLEKE 1222
Cdd:pfam05483  166 RSAEKTKKYEYEREETRQVYMDLNNNIE----KMILAFEELRVQAENARLEMHFK--------------LKEDHEKIQHL 227
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1223 KSEFKLELDDVtsnmeqiikakanlekvsrtlEDQANEYRVKLEEAQRSLNDFTTqrakLQTENGELARQLEEKEAL--- 1299
Cdd:pfam05483  228 EEEYKKEINDK---------------------EKQVSLLLIQITEKENKMKDLTF----LLEESRDKANQLEEKTKLqde 282
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1300 -ISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSSRHDCDLLREQYEEEME----AKAELQRVLSKANSEVAQWR 1374
Cdd:pfam05483  283 nLKELIEKKDHLTKELEDIKMSLQRSMSTQKALEEDLQIATKTICQLTEEKEAQMEelnkAKAAHSFVVTEFEATTCSLE 362
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1375 TKYETDAiQRTEELEEAKKKLAQRLQ----DAEEAVEAVNAKCSSLEKTKHRLqNEIEDLMVDVERSNAAAAALDKKQRN 1450
Cdd:pfam05483  363 ELLRTEQ-QRLEKNEDQLKIITMELQkkssELEEMTKFKNNKEVELEELKKIL-AEDEKLLDEKKQFEKIAEELKGKEQE 440
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1451 F-------DKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGK 1523
Cdd:pfam05483  441 LifllqarEKEIHDLEIQLTAIKTSEEHYLKEVEDLKTELEKEKLKNIELTAHCDKLLLENKELTQEASDMTLELKKHQE 520
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1524 NV----HELEKIRKQ---LEVEKLELQSALEEAEASL--EHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLR 1594
Cdd:pfam05483  521 DIinckKQEERMLKQienLEEKEMNLRDELESVREEFiqKGDEVKCKLDKSEENARSIEYEVLKKEKQMKILENKCNNLK 600
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1595 MVDSLQTSLDAETRSRNEALRVKKKMEG-DLNEMEIQLSQAN-RIASEAQKH---LKNSQAHLKDTQLQ----LDDAVHA 1665
Cdd:pfam05483  601 KQIENKNKNIEELHQENKALKKKGSAENkQLNAYEIKVNKLElELASAKQKFeeiIDNYQKEIEDKKISeeklLEEVEKA 680
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1666 NDDLKENIAIVERRNNLLQAELEELRAVVEQTERS------RKLAEQELIETSERVQ--LLHSQNTSLINQKKKMESDLT 1737
Cdd:pfam05483  681 KAIADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQydkiieERDSELGLYKNKEQEQssAKAALEIELSNIKAELLSLKK 760
                          730
                   ....*....|....*...
gi 6754774    1738 QLQTEVEEAVQECRNAEE 1755
Cdd:pfam05483  761 QLEIEKEEKEKLKMEAKE 778
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1442-1882 1.83e-08

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 59.40  E-value: 1.83e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1442 AALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLtEQLGEG 1521
Cdd:COG4717   49 ERLEKEADELFKPQGRKPELNLKELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKL-EKLLQL 127
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1522 GKNVHELEKIRKQLEVEKLELQsALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRMVDSLQT 1601
Cdd:COG4717  128 LPLYQELEALEAELAELPERLE-ELEERLEELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQ 206
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1602 SLDAETRSRNEALRVKKKMEGDLNEMEIQLsqanrIASEAQKHLKNSQAHLK--DTQLQLDDAVHANDDLKENIA----- 1674
Cdd:COG4717  207 RLAELEEELEEAQEELEELEEELEQLENEL-----EAAALEERLKEARLLLLiaAALLALLGLGGSLLSLILTIAgvlfl 281
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1675 ------IVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQTEVEEAVQ 1748
Cdd:COG4717  282 vlgllaLLFLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEE 361
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1749 ECRNAEEKAKKA----------ITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKggkKQLQKLE 1818
Cdd:COG4717  362 ELQLEELEQEIAallaeagvedEEELRAALEQAEEYQELKEELEELEEQLEELLGELEELLEALDEEELE---EELEELE 438
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6754774  1819 ARVRELENELEAEQKRnaesvkgMRKSERRIKELTYQTEEDKKnLMRLQDLVDKLQLKVKAYKR 1882
Cdd:COG4717  439 EELEELEEELEELREE-------LAELEAELEQLEEDGELAEL-LQELEELKAELRELAEEWAA 494
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1188-1593 2.23e-08

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 59.40  E-value: 2.23e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1188 EATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFK---LELDDVTSNMEQIIKAKANLEKVSRTLED--QANEYR 1262
Cdd:COG4717   52 EKEADELFKPQGRKPELNLKELKELEEELKEAEEKEEEYAelqEELEELEEELEELEAELEELREELEKLEKllQLLPLY 131
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1263 VKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKlsytQQMEDLKRQLEEEgkAKNALAHALQSSRHdc 1342
Cdd:COG4717  132 QELEALEAELAELPERLEELEERLEELRELEEELEELEAELAELQ----EELEELLEQLSLA--TEEELQDLAEELEE-- 203
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1343 dlLREQYEEEMEAKAELQRVLSKANSEVAQWRTKYETDAIQrtEELEEAK------------------------------ 1392
Cdd:COG4717  204 --LQQRLAELEEELEEAQEELEELEEELEQLENELEAAALE--ERLKEARlllliaaallallglggsllsliltiagvl 279
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1393 -----------KKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQk 1461
Cdd:COG4717  280 flvlgllallfLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEE- 358
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1462 yeesqSELESSQKEARSLSTELFKLKNA-YEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKI--RKQLEVE 1538
Cdd:COG4717  359 -----LEEELQLEELEQEIAALLAEAGVeDEEELRAALEQAEEYQELKEELEELEEQLEELLGELEELLEAldEEELEEE 433
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6754774  1539 KLELQSALEEAEASLE--HEEGKILRAQLE-------FNQIKAEIERKLAEKDEEMEQAKRNHL 1593
Cdd:COG4717  434 LEELEEELEELEEELEelREELAELEAELEqleedgeLAELLQELEELKAELRELAEEWAALKL 497
mukB PRK04863
chromosome partition protein MukB;
888-1430 2.56e-08

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 59.59  E-value: 2.56e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    888 DLQLQVQAEQdNLNDAEERCDQLIKNKIQLEAKVKEMTERLEDEEEMNAELTAKKRKLEDECSELKKDIDdlelTLAKVE 967
Cdd:PRK04863  528 RLRQQQRAER-LLAEFCKRLGKNLDDEDELEQLQEELEARLESLSESVSEARERRMALRQQLEQLQARIQ----RLAARA 602
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    968 KEKHATENKVKNLTEEM-------AGLDEIIAKLTKEKKALQ------EAHQQALDD----LQ----AEEDKVNTL--TK 1024
Cdd:PRK04863  603 PAWLAAQDALARLREQSgeefedsQDVTEYMQQLLERERELTverdelAARKQALDEeierLSqpggSEDPRLNALaeRF 682
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1025 SKVKLEQQVDDLE-----------GSLEQEKKVRmDLERAKRKLEG------DLKLTQESIMDLENDKLQLEEKLKkkef 1087
Cdd:PRK04863  683 GGVLLSEIYDDVSledapyfsalyGPARHAIVVP-DLSDAAEQLAGledcpeDLYLIEGDPDSFDDSVFSVEELEK---- 757
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1088 DISQQNSKIedeqalalqlqkklkenQARIEELEEELEAERTARakvEKLRSDLSRELEEISERLEeaggatsvqiemnk 1167
Cdd:PRK04863  758 AVVVKIADR-----------------QWRYSRFPEVPLFGRAAR---EKRIEQLRAEREELAERYA-------------- 803
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1168 KREAEFQKMRR---DLEEATLQH---------EATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLelddvts 1235
Cdd:PRK04863  804 TLSFDVQKLQRlhqAFSRFIGSHlavafeadpEAELRQLNRRRVELERALADHESQEQQQRSQLEQAKEGLSA------- 876
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1236 nMEQIIKAKANLEKvsRTLEDQANEYRVKLEEAQ----------RSLNDFTTQRAKLQTENGELA---RQLEEKEALISQ 1302
Cdd:PRK04863  877 -LNRLLPRLNLLAD--ETLADRVEEIREQLDEAEeakrfvqqhgNALAQLEPIVSVLQSDPEQFEqlkQDYQQAQQTQRD 953
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1303 LTRGK--LSYTQQM------EDLKRQLEEEGKAKNALAHALQSSRHDCDLLREQYEEEMEAKAELQRVLSKANSEvaqWR 1374
Cdd:PRK04863  954 AKQQAfaLTEVVQRrahfsyEDAAEMLAKNSDLNEKLRQRLEQAEQERTRAREQLRQAQAQLAQYNQVLASLKSS---YD 1030
                         570       580       590       600       610       620
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6754774   1375 TKYET--DAIQRTEEL-----EEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDL 1430
Cdd:PRK04863 1031 AKRQMlqELKQELQDLgvpadSGAEERARARRDELHARLSANRSRRNQLEKQLTFCEAEMDNL 1093
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1237-1707 3.09e-08

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 58.63  E-value: 3.09e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1237 MEQIIKAKANLEKVS-RTLEDQANEYRvKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLtRGKLSYTQQME 1315
Cdd:COG4717   48 LERLEKEADELFKPQgRKPELNLKELK-ELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEEL-REELEKLEKLL 125
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1316 DLKRQLEEEGKAKNALAhalqssrhDCDLLREQYEEEMEAKAELQRVLSKANSEVAQWRTkyetdaiQRTEELEEAKKKL 1395
Cdd:COG4717  126 QLLPLYQELEALEAELA--------ELPERLEELEERLEELRELEEELEELEAELAELQE-------ELEELLEQLSLAT 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1396 AQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDK------------ILAEWKQKYE 1463
Cdd:COG4717  191 EEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERLKEArlllliaaallaLLGLGGSLLS 270
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1464 ESQSELESSQKEARSLS---TELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLG-EGGKNVHELEKIRKQLEvEK 1539
Cdd:COG4717  271 LILTIAGVLFLVLGLLAllfLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGlPPDLSPEELLELLDRIE-EL 349
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1540 LELQSALEEAEASLEHEEGKILRAQLeFNQIKAEIERKLAEKDEEMEQAkRNHLRMVDSLQTSLDAETRSRNEALRvkkk 1619
Cdd:COG4717  350 QELLREAEELEEELQLEELEQEIAAL-LAEAGVEDEEELRAALEQAEEY-QELKEELEELEEQLEELLGELEELLE---- 423
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1620 mEGDLNEMEIQLSQANRIASEAQKHLKNSQAHLKDTQLQLDDAVHAN--DDLKENIAIVERRNNLLQAELEELRAVVEQT 1697
Cdd:COG4717  424 -ALDEEELEEELEELEEELEELEEELEELREELAELEAELEQLEEDGelAELLQELEELKAELRELAEEWAALKLALELL 502
                        490
                 ....*....|
gi 6754774  1698 ERSRKLAEQE 1707
Cdd:COG4717  503 EEAREEYREE 512
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
1014-1412 3.28e-08

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 58.93  E-value: 3.28e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1014 AEEDKVNTLTKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDISQQN 1093
Cdd:TIGR02169  671 SEPAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLE 750
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1094 SKIEDEQALALQLQKKLKENQARIEELeeeleaertaRAKVEKLRSDLSRELEEISERLEEAGGATSVQIEmNKKREAEF 1173
Cdd:TIGR02169  751 QEIENVKSELKELEARIEELEEDLHKL----------EEALNDLEARLSHSRIPEIQAELSKLEEEVSRIE-ARLREIEQ 819
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1174 QKMRRDLEEATLQHE-ATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSR 1252
Cdd:TIGR02169  820 KLNRLTLEKEYLEKEiQELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEELEAALRDLESRLGDLKKERDELEAQLR 899
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1253 TLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQltrgklsyTQQMEDLKRQLEEEGKAKNALA 1332
Cdd:TIGR02169  900 ELERKIEELEAQIEKKRKRLSELKAKLEALEEELSEIEDPKGEDEEIPEE--------ELSLEDVQAELQRVEEEIRALE 971
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1333 halqssrhDCDLLR-EQYEEEMEAKAELQRVLSKANSEvaqwrtkyETDAIQRTEELEEAKKKLAQrlqdaeEAVEAVNA 1411
Cdd:TIGR02169  972 --------PVNMLAiQEYEEVLKRLDELKEKRAKLEEE--------RKAILERIEEYEKKKREVFM------EAFEAINE 1029

                   .
gi 6754774    1412 K 1412
Cdd:TIGR02169 1030 N 1030
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1128-1613 3.87e-08

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 58.77  E-value: 3.87e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1128 RTARAKVEKLRsdlsrELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATL-----------QHEATAAALRK 1196
Cdd:COG4913  245 EDAREQIELLE-----PIRELAERYAAARERLAELEYLRAALRLWFAQRRLELLEAELeelraelarleAELERLEARLD 319
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1197 KHADSVAELGEQIDNLQ-RVKQKLEKEKSEFKLELDDVTSN----MEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRS 1271
Cdd:COG4913  320 ALREELDELEAQIRGNGgDRLEQLEREIERLERELEERERRrarlEALLAALGLPLPASAEEFAALRAEAAALLEALEEE 399
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1272 LNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEE-GKAKNAL------------------- 1331
Cdd:COG4913  400 LEALEEALAEAEAALRDLRRELRELEAEIASLERRKSNIPARLLALRDALAEAlGLDEAELpfvgelievrpeeerwrga 479
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1332 ----------------AHALQSSRH----------DCDLLREQYEEEMEAKAE---LQRVLSKANSEVAQW---RTKYET 1379
Cdd:COG4913  480 iervlggfaltllvppEHYAAALRWvnrlhlrgrlVYERVRTGLPDPERPRLDpdsLAGKLDFKPHPFRAWleaELGRRF 559
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1380 DAIQ--RTEELEEAKK---------------------KLAQRL---QDAEEAVEAvnakcssLEKTKHRLQNEIEDLMVD 1433
Cdd:COG4913  560 DYVCvdSPEELRRHPRaitragqvkgngtrhekddrrRIRSRYvlgFDNRAKLAA-------LEAELAELEEELAEAEER 632
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1434 VERSNAAAAALDKKQRNFDKIlaewkQKYEESQSELESSQKEARSLSTELFKLknayEESLEHLETFKRENKNLQEEISD 1513
Cdd:COG4913  633 LEALEAELDALQERREALQRL-----AEYSWDEIDVASAEREIAELEAELERL----DASSDDLAALEEQLEELEAELEE 703
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1514 LTEQLGEGGKNVHELEKIRKQLEVEKLELQSALEEAEASLEHEegkiLRAQLEfnqikaeiERKLAEKDEEMEQakrnhl 1593
Cdd:COG4913  704 LEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLE----LRALLE--------ERFAAALGDAVER------ 765
                        570       580
                 ....*....|....*....|
gi 6754774  1594 RMVDSLQTSLDAETRSRNEA 1613
Cdd:COG4913  766 ELRENLEERIDALRARLNRA 785
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1216-1443 3.94e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 57.85  E-value: 3.94e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1216 KQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEE 1295
Cdd:COG4942   22 AAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEA 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1296 KEALISQLTRG--KLSYTQQMEDLKRQleeegKAKNALAHALQSSRHDCDLLREQYEEEMEAKAELQRVLSKANSEVAQW 1373
Cdd:COG4942  102 QKEELAELLRAlyRLGRQPPLALLLSP-----EDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAEL 176
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1374 RTKYETDAIQRtEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAA 1443
Cdd:COG4942  177 EALLAELEEER-AALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPA 245
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1666-1899 5.11e-08

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 58.10  E-value: 5.11e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1666 NDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRK--LAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQTEV 1743
Cdd:COG3206  163 EQNLELRREEARKALEFLEEQLPELRKELEEAEAALEefRQKNGLVDLSEEAKLLLQQLSELESQLAEARAELAEAEARL 242
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1744 EeAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMK----------KNMEQTIKDLQHRLDEAEQIALKGGKKQ 1813
Cdd:COG3206  243 A-ALRAQLGSGPDALPELLQSPVIQQLRAQLAELEAELAELSarytpnhpdvIALRAQIAALRAQLQQEAQRILASLEAE 321
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1814 LQKLEARVRELENELEAEQKRnaesVKGMRKSERRIKELTYQTEEDKKNLMRLQDlvdklqlkvkaykrQAEEAEEQANT 1893
Cdd:COG3206  322 LEALQAREASLQAQLAQLEAR----LAELPELEAELRRLEREVEVARELYESLLQ--------------RLEEARLAEAL 383

                 ....*.
gi 6754774  1894 NLSKFR 1899
Cdd:COG3206  384 TVGNVR 389
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1047-1282 5.50e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 57.08  E-value: 5.50e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1047 RMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDISQQNSKIEDEQALALQLQKKLKENQARIEELEEELEA 1126
Cdd:COG4942   22 AAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEA 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1127 ERTARAKVEKLRSDLSR--ELEEI--SERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEatlqheatAAALRKKHADSV 1202
Cdd:COG4942  102 QKEELAELLRALYRLGRqpPLALLlsPEDFLDAVRRLQYLKYLAPARREQAEELRADLAE--------LAALRAELEAER 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1203 AELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSL--NDFTTQRA 1280
Cdd:COG4942  174 AELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTpaAGFAALKG 253

                 ..
gi 6754774  1281 KL 1282
Cdd:COG4942  254 KL 255
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
865-1396 5.58e-08

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 58.31  E-value: 5.58e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     865 LEKSEARRKELEEKMVSLLQEKNDLQLQVQAE-QDNLNDAEERCDQLIKNKIQLEAKVKEMTERLEdeEEMNAELTAKKR 943
Cdd:pfam12128  356 LENLEERLKALTGKHQDVTAKYNRRRSKIKEQnNRDIAGIKDKLAKIREARDRQLAVAEDDLQALE--SELREQLEAGKL 433
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     944 KLEDECSELKKDIDDLELTLAKVEKEKHATENKvKNLTEEMAGLDEIIAKLTKEKKALQE-------AHQQALDDLQAEE 1016
Cdd:pfam12128  434 EFNEEEYRLKSRLGELKLRLNQATATPELLLQL-ENFDERIERAREEQEAANAEVERLQSelrqarkRRDQASEALRQAS 512
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1017 DKVNTLTKSKVKLEQQVDDLEGSL------------EQEKKV-------RMDLERAKRKLEGDLKLTQESI-MDLE---- 1072
Cdd:pfam12128  513 RRLEERQSALDELELQLFPQAGTLlhflrkeapdweQSIGKVispellhRTDLDPEVWDGSVGGELNLYGVkLDLKridv 592
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1073 NDKLQLEEKLKKKefdISQQNSKIEDEQALALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERL 1152
Cdd:pfam12128  593 PEWAASEEELRER---LDKAEEALQSAREKQAAAEEQLVQANGELEKASREETFARTALKNARLDLRRLFDEKQSEKDKK 669
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1153 EEAGGA---------TSVQIEMN---KKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQ-RVKQKL 1219
Cdd:pfam12128  670 NKALAErkdsanerlNSLEAQLKqldKKHQAWLEEQKEQKREARTEKQAYWQVVEGALDAQLALLKAAIAARRsGAKAEL 749
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1220 EKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQAneyrvKLEEAQRSLNDFttQRAKLQTENGELARQLEEKEAL 1299
Cdd:pfam12128  750 KALETWYKRDLASLGVDPDVIAKLKREIRTLERKIERIA-----VRRQEVLRYFDW--YQETWLQRRPRLATQLSNIERA 822
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1300 ISQLtRGKLsyTQQMEDLKR---QLEEEGKAKNALAHALQSSRHDCDLLREQYEEEMEAK--AELQRVLSKANSEVAQWR 1374
Cdd:pfam12128  823 ISEL-QQQL--ARLIADTKLrraKLEMERKASEKQQVRLSENLRGLRCEMSKLATLKEDAnsEQAQGSIGERLAQLEDLK 899
                          570       580
                   ....*....|....*....|..
gi 6754774    1375 TKYETDAIQRTEELEEAKKKLA 1396
Cdd:pfam12128  900 LKRDYLSESVKKYVEHFKNVIA 921
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1199-1415 6.84e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 57.08  E-value: 6.84e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1199 ADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQ 1278
Cdd:COG4942   19 ADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAE 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1279 RAKLQTENGELARQLEEKEAL-----------ISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSSRHDCDLLRE 1347
Cdd:COG4942   99 LEAQKEELAELLRALYRLGRQpplalllspedFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELEA 178
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6754774  1348 QYEEEMEAKAELQRVLSKANSEVAQWRTKYETDAiQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSS 1415
Cdd:COG4942  179 LLAELEEERAALEALKAERQKLLARLEKELAELA-AELAELQQEAEELEALIARLEAEAAAAAERTPA 245
PRK01156 PRK01156
chromosome segregation protein; Provisional
835-1305 7.81e-08

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 57.60  E-value: 7.81e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    835 YFKIKPLLKSAETE-KEMANMKEEFGRVKDALEKSEARRKELEEKMVSLLQEKNDLQLQVQA---EQDNLNDAEERCDQL 910
Cdd:PRK01156  168 YDKLKDVIDMLRAEiSNIDYLEEKLKSSNLELENIKKQIADDEKSHSITLKEIERLSIEYNNamdDYNNLKSALNELSSL 247
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    911 IKNKIQLEAKVKEMTERLEDEEEMNAELTA--------------KKRKLEDECSELKKDIDDLELTLAKVEKEKHATENK 976
Cdd:PRK01156  248 EDMKNRYESEIKTAESDLSMELEKNNYYKEleerhmkiindpvyKNRNYINDYFKYKNDIENKKQILSNIDAEINKYHAI 327
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    977 VKNLTEEMAGLDEIIakltkEKKALQEAHQQALDDLQAEEDKVNTLTKS----KVKLE---------------------- 1030
Cdd:PRK01156  328 IKKLSVLQKDYNDYI-----KKKSRYDDLNNQILELEGYEMDYNSYLKSieslKKKIEeyskniermsafiseilkiqei 402
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1031 ----------------QQVDDLEGSLEQEKKV----RMDLERAKRKLEGDLK-------LTQESIMDL----ENDKLQLE 1079
Cdd:PRK01156  403 dpdaikkelneinvklQDISSKVSSLNQRIRAlrenLDELSRNMEMLNGQSVcpvcgttLGEEKSNHIinhyNEKKSRLE 482
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1080 EKLKKKEFDISQQNSKIEDEQALALQLQK-----------KLKENQARIEELEEELEAERTARAKVEKLRSDL-SRELEE 1147
Cdd:PRK01156  483 EKIREIEIEVKDIDEKIVDLKKRKEYLESeeinksineynKIESARADLEDIKIKINELKDKHDKYEEIKNRYkSLKLED 562
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1148 ISERLEEAGGATSV----QIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEK 1223
Cdd:PRK01156  563 LDSKRTSWLNALAVisliDIETNRSRSNEIKKQLNDLESRLQEIEIGFPDDKSYIDKSIREIENEANNLNNKYNEIQENK 642
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1224 SEFKlELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQL 1303
Cdd:PRK01156  643 ILIE-KLRGKIDNYKKQIAEIDSIIPDLKEITSRINDIEDNLKKSRKALDDAKANRARLESTIEILRTRINELSDRINDI 721

                  ..
gi 6754774   1304 TR 1305
Cdd:PRK01156  722 NE 723
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1617-1850 8.23e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 56.70  E-value: 8.23e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1617 KKKMEGDLNEMEIQLSQANRIASEAQKHLKNSQAHLKDTQLQLDDAVHANDDLKENIAIVERRNNLLQAELEELRAVVEQ 1696
Cdd:COG4942   22 AAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEA 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1697 TER--SRKLAEQELIETSERVQLLHSQNTS--LINQKKKMESDLTQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELK 1772
Cdd:COG4942  102 QKEelAELLRALYRLGRQPPLALLLSPEDFldAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELEALLA 181
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6754774  1773 KEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIAlkggkKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIK 1850
Cdd:COG4942  182 ELEEERAALEALKAERQKLLARLEKELAELAAEL-----AELQQEAEELEALIARLEAEAAAAAERTPAAGFAALKGK 254
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
1417-1922 9.66e-08

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 57.34  E-value: 9.66e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1417 EKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKnAYEESLEH 1496
Cdd:TIGR04523  137 KKNIDKFLTEIKKKEKELEKLNNKYNDLKKQKEELENELNLLEKEKLNIQKNIDKIKNKLLKLELLLSNLK-KKIQKNKS 215
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1497 LET----FKRENKNLQEEISDLTEQLGEGGKNVHELEKIRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKA 1572
Cdd:TIGR04523  216 LESqiseLKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQLSEKQKELEQNNKKIKELEKQLNQLKS 295
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1573 EIERKLAEKDEEMEQAKRNHLRMVDS----LQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSQANRIASEAQKHLKNS 1648
Cdd:TIGR04523  296 EISDLNNQKEQDWNKELKSELKNQEKkleeIQNQISQNNKIISQLNEQISQLKKELTNSESENSEKQRELEEKQNEIEKL 375
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1649 QAHLKDTQLQLDDAVHANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQ 1728
Cdd:TIGR04523  376 KKENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKELI 455
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1729 KKKMESDLTQLQTEVEEAVQECRNAEEKAKKaitdaamMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALK 1808
Cdd:TIGR04523  456 IKNLDNTRESLETQLKVLSRSINKIKQNLEQ-------KQKELKSKEKELKKLNEEKKELEEKVKDLTKKISSLKEKIEK 528
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1809 GGKKQLQKlEARVRELENELEAEQKRNAESV--KGMRKSERRIKELTYQTEEDKKNLMRLQDLVDKLQLKVKAYKRQAEE 1886
Cdd:TIGR04523  529 LESEKKEK-ESKISDLEDELNKDDFELKKENleKEIDEKNKEIEELKQTQKSLKKKQEEKQELIDQKEKEKKDLIKEIEE 607
                          490       500       510
                   ....*....|....*....|....*....|....*.
gi 6754774    1887 AEEQANTNLSKFRKVQHELDEAEERADIAESQVNKL 1922
Cdd:TIGR04523  608 KEKKISSLEKELEKAKKENEKLSSIIKNIKSKKNKL 643
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
1187-1911 1.04e-07

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 57.54  E-value: 1.04e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1187 HEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLE 1266
Cdd:pfam12128  228 RDIQAIAGIMKIRPEFTKLQQEFNTLESAELRLSHLHFGYKSDETLIASRQEERQETSAELNQLLRTLDDQWKEKRDELN 307
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1267 eaqrslNDFTTQRAKLQTENGELARqLEEKEALISQLTRGKLSYTQQMEDLKR-QLEEEGKAKNALAHALQssrhdcDLL 1345
Cdd:pfam12128  308 ------GELSAADAAVAKDRSELEA-LEDQHGAFLDADIETAAADQEQLPSWQsELENLEERLKALTGKHQ------DVT 374
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1346 REQYEEEMEAKAELQRVLSKANSEVAQwrtKYETDAIQRTEElEEAKKKLAQRLQDAEEAVEAvnakcsSLEKTKHRLQN 1425
Cdd:pfam12128  375 AKYNRRRSKIKEQNNRDIAGIKDKLAK---IREARDRQLAVA-EDDLQALESELREQLEAGKL------EFNEEEYRLKS 444
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1426 EIEDLMVdveRSNAAAAALDKK--QRNFDKILAEWKQKyeesqseLESSQKEARSLSTELFKLKNAYEESLEHLETFKRE 1503
Cdd:pfam12128  445 RLGELKL---RLNQATATPELLlqLENFDERIERAREE-------QEAANAEVERLQSELRQARKRRDQASEALRQASRR 514
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1504 NKNLQEEISDLTEQLGEGGKNVHEL---------EKIRKQLEVEKL---ELQSALEEAEASLEheegkilraqLEFNQIK 1571
Cdd:pfam12128  515 LEERQSALDELELQLFPQAGTLLHFlrkeapdweQSIGKVISPELLhrtDLDPEVWDGSVGGE----------LNLYGVK 584
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1572 AEIERKLAEKDEEMEQAKRnhlRMVDSLQTSLDAEtRSRNEALrvkkkmegdlnemEIQLSQANRIASEAQKHLKNSQAH 1651
Cdd:pfam12128  585 LDLKRIDVPEWAASEEELR---ERLDKAEEALQSA-REKQAAA-------------EEQLVQANGELEKASREETFARTA 647
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1652 LK---DTQLQLDDaVHANDDLKENIAIvERRNNLLQAELEELRAVVEQTERSRKLAEQELIETServqllhSQNTSLINQ 1728
Cdd:pfam12128  648 LKnarLDLRRLFD-EKQSEKDKKNKAL-AERKDSANERLNSLEAQLKQLDKKHQAWLEEQKEQK-------REARTEKQA 718
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1729 KKKMESDLTQLQtevEEAVQECRNAEEKAKKAITDA--AMMAEELKK---EQDTSAHLERMKKNMEQTIKDLQHRLDEA- 1802
Cdd:pfam12128  719 YWQVVEGALDAQ---LALLKAAIAARRSGAKAELKAleTWYKRDLASlgvDPDVIAKLKREIRTLERKIERIAVRRQEVl 795
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1803 --EQIALKGGKKQLQKLEARVRELEN---ELEAEQKRNAESVKGMRKS-ERRIKELTYQTEEDKKNLMRLQDLVDKL-QL 1875
Cdd:pfam12128  796 ryFDWYQETWLQRRPRLATQLSNIERaisELQQQLARLIADTKLRRAKlEMERKASEKQQVRLSENLRGLRCEMSKLaTL 875
                          730       740       750
                   ....*....|....*....|....*....|....*.
gi 6754774    1876 KVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEER 1911
Cdd:pfam12128  876 KEDANSEQAQGSIGERLAQLEDLKLKRDYLSESVKK 911
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
863-1095 1.08e-07

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 56.31  E-value: 1.08e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   863 DALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKIQLEAKVKEMTERLedeeemnAELTAKK 942
Cdd:COG4942   20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAEL-------AELEKEI 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   943 RKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTL 1022
Cdd:COG4942   93 AELRAELEAQKEELAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAE 172
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6754774  1023 TKSKVKLEQQVDDLEGSLEQEKKVRmdlERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDISQQNSK 1095
Cdd:COG4942  173 RAELEALLAELEEERAALEALKAER---QKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAER 242
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1040-1449 1.71e-07

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 56.31  E-value: 1.71e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1040 LEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDISQQNSKIEDEQalalqLQKKLKENQARIEE 1119
Cdd:COG4717   76 LEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQLLPLYQELEA-----LEAELAELPERLEE 150
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1120 LEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHA 1199
Cdd:COG4717  151 LEERLEELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELE 230
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1200 DSVAELgeqidNLQRVKQKLEKEKSEFK-----LELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLND 1274
Cdd:COG4717  231 QLENEL-----EAAALEERLKEARLLLLiaaalLALLGLGGSLLSLILTIAGVLFLVLGLLALLFLLLAREKASLGKEAE 305
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1275 FTTQRAKLQT-ENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALahALQSSRHDCDLLREQY---- 1349
Cdd:COG4717  306 ELQALPALEElEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEEL--QLEELEQEIAALLAEAgved 383
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1350 EEEMEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKK-LAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIE 1428
Cdd:COG4717  384 EEELRAALEQAEEYQELKEELEELEEQLEELLGELEELLEALDEEeLEEELEELEEELEELEEELEELREELAELEAELE 463
                        410       420
                 ....*....|....*....|.
gi 6754774  1429 DLMVDVERSNAAAAALDKKQR 1449
Cdd:COG4717  464 QLEEDGELAELLQELEELKAE 484
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
917-1604 1.96e-07

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 56.39  E-value: 1.96e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     917 LEAKVKEMTERLEDEEEMNAELTAKKRkledecSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTK 996
Cdd:pfam12128  263 LHFGYKSDETLIASRQEERQETSAELN------QLLRTLDDQWKEKRDELNGELSAADAAVAKDRSELEALEDQHGAFLD 336
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     997 EKKALQEAHQQALDDLQAE-----------EDKVNTLT------KSKVKlEQQVDDLEGSLEQEKKVRMDLERAKRKLEG 1059
Cdd:pfam12128  337 ADIETAAADQEQLPSWQSElenleerlkalTGKHQDVTakynrrRSKIK-EQNNRDIAGIKDKLAKIREARDRQLAVAED 415
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1060 DLKlTQESIMDLENDKLQLEEKLKKKEFDISQQNSKIEDEQALAlqlQKKLKENQARIEELEEELEAERT-ARAKVEKLR 1138
Cdd:pfam12128  416 DLQ-ALESELREQLEAGKLEFNEEEYRLKSRLGELKLRLNQATA---TPELLLQLENFDERIERAREEQEaANAEVERLQ 491
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1139 SDLsRELEEISERLEEAGGATSVQIEMNKKREAEFQKMrRDLEEATLQHeataaALRKKHADSVAELGEQIDNLQRVKQK 1218
Cdd:pfam12128  492 SEL-RQARKRRDQASEALRQASRRLEERQSALDELELQ-LFPQAGTLLH-----FLRKEAPDWEQSIGKVISPELLHRTD 564
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1219 LEKEKSE-----------FKLELDDVTSN----MEQIIKAKanLEKVSRTL----------EDQANEYRVKLEEAQRSLn 1273
Cdd:pfam12128  565 LDPEVWDgsvggelnlygVKLDLKRIDVPewaaSEEELRER--LDKAEEALqsarekqaaaEEQLVQANGELEKASREE- 641
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1274 dfTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEgkaKNALAHALQssrhdcDLLREQYEEEM 1353
Cdd:pfam12128  642 --TFARTALKNARLDLRRLFDEKQSEKDKKNKALAERKDSANERLNSLEAQ---LKQLDKKHQ------AWLEEQKEQKR 710
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1354 EAKAELQrvlskansevAQWRtkyetdaiqrteELEEAKK-KLAQRLQDAEEAVEAVNAKCSSLEKTKHRlqnEIEDLMV 1432
Cdd:pfam12128  711 EARTEKQ----------AYWQ------------VVEGALDaQLALLKAAIAARRSGAKAELKALETWYKR---DLASLGV 765
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1433 DVERsnaaAAALDKKQRNFDKILAEWKQKyeesqselessqkeaRSLSTELFKLKNayEESLEHLETFKRENKNLQEEIS 1512
Cdd:pfam12128  766 DPDV----IAKLKREIRTLERKIERIAVR---------------RQEVLRYFDWYQ--ETWLQRRPRLATQLSNIERAIS 824
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1513 DLTEQLgegGKNVHELEKIRKQLEVEKLELQSALEEAEASLEHEEGKILR-AQLEFNQIKAEIERKLAEKDEEMEQAKRN 1591
Cdd:pfam12128  825 ELQQQL---ARLIADTKLRRAKLEMERKASEKQQVRLSENLRGLRCEMSKlATLKEDANSEQAQGSIGERLAQLEDLKLK 901
                          730
                   ....*....|...
gi 6754774    1592 HLRMVDSLQTSLD 1604
Cdd:pfam12128  902 RDYLSESVKKYVE 914
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1237-1452 2.25e-07

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 56.18  E-value: 2.25e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1237 MEQIIKAK-ANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQR--AKLQTENGELARQLEEKEALISQLTRGKLSYTQQ 1313
Cdd:COG3206  162 LEQNLELRrEEARKALEFLEEQLPELRKELEEAEAALEEFRQKNglVDLSEEAKLLLQQLSELESQLAEARAELAEAEAR 241
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1314 MEDLKRQLEEEGKAKNALAHALQSSRhdcdlLREQYEEEMEAKAELQRVLSKANSEVAQWRtkyetdaiqrtEELEEAKK 1393
Cdd:COG3206  242 LAALRAQLGSGPDALPELLQSPVIQQ-----LRAQLAELEAELAELSARYTPNHPDVIALR-----------AQIAALRA 305
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 6754774  1394 KLAQRLQDAEEAVEAVNAkcsSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFD 1452
Cdd:COG3206  306 QLQQEAQRILASLEAELE---ALQAREASLQAQLAQLEARLAELPELEAELRRLEREVE 361
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
854-1295 2.97e-07

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 55.60  E-value: 2.97e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     854 MKEEFGRVKDALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLiknkiqlEAKVKEMTERLEDEEE 933
Cdd:pfam10174  287 MKNKIDQLKQELSKKESELLALQTKLETLTNQNSDCKQHIEVLKESLTAKEQRAAIL-------QTEVDALRLRLEEKES 359
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     934 MNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQA----- 1008
Cdd:pfam10174  360 FLNKKTKQLQDLTEEKSTLAGEIRDLKDMLDVKERKINVLQKKIENLQEQLRDKDKQLAGLKERVKSLQTDSSNTdtalt 439
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1009 -LDDLQAEEDKV-NTLTKSKVKLEQQVDDlegSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKE 1086
Cdd:pfam10174  440 tLEEALSEKERIiERLKEQREREDRERLE---ELESLKKENKDLKEKVSALQPELTEKESSLIDLKEHASSLASSGLKKD 516
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1087 FDISQQNSKIEDEQALALQLQKKLKENQarieeleeelEAERTARAKVEklRSDLSRELE-EISERLEEAGGA-TSVQIE 1164
Cdd:pfam10174  517 SKLKSLEIAVEQKKEECSKLENQLKKAH----------NAEEAVRTNPE--INDRIRLLEqEVARYKEESGKAqAEVERL 584
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1165 MNKKREAEFQKMRRDLEEATLqhEATAAALRKKHADSVAEL--GEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIK 1242
Cdd:pfam10174  585 LGILREVENEKNDKDKKIAEL--ESLTLRQMKEQNKKVANIkhGQQEMKKKGAQLLEEARRREDNLADNSQQLQLEELMG 662
                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|...
gi 6754774    1243 AkanLEKVSRTLEdqanEYRVKLEEAQRSLNDFTTQRAKLQtenGELARQLEE 1295
Cdd:pfam10174  663 A---LEKTRQELD----ATKARLSSTQQSLAEKDGHLTNLR---AERRKQLEE 705
EzrA pfam06160
Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like ...
1483-1929 3.22e-07

Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like cell-division protein FtsZ polymerizes into a ring structure that establishes the location of the nascent division site. EzrA modulates the frequency and position of FtsZ ring formation. The structure contains 5 spectrin like alpha helical repeats.


Pssm-ID: 428797 [Multi-domain]  Cd Length: 542  Bit Score: 55.25  E-value: 3.22e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1483 LFKLKNAYEEsLEHLETFKRE--NKNLQEEISDLtEQLGEGGKNVHELEKIRKQ----LEVEKLELQSALEEAEASLEhe 1556
Cdd:pfam06160    2 LLLRKKIYKE-IDELEERKNElmNLPVQEELSKV-KKLNLTGETQEKFEEWRKKwddiVTKSLPDIEELLFEAEELND-- 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1557 EGKILRAQLEFNqikaEIERKLAEKDEEMEQakrnhlrMVDSLQTSLDAETRSRNEALRVKKK----------------- 1619
Cdd:pfam06160   78 KYRFKKAKKALD----EIEELLDDIEEDIKQ-------ILEELDELLESEEKNREEVEELKDKyrelrktllanrfsygp 146
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1620 ----MEGDLNEMEIQLSQANRiaseaqkhLKNSQAHL--KDTQLQLDDAVHANDDLKENI-AIVERRNNLLQAELEELRA 1692
Cdd:pfam06160  147 aideLEKQLAEIEEEFSQFEE--------LTESGDYLeaREVLEKLEEETDALEELMEDIpPLYEELKTELPDQLEELKE 218
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1693 VVEQTERSR-KLAEQELIETSERVQLLHSQNTSLINQK--KKMESDLTQLQTEVEEaVQECRNAEEKAKKaitdaammae 1769
Cdd:pfam06160  219 GYREMEEEGyALEHLNVDKEIQQLEEQLEENLALLENLelDEAEEALEEIEERIDQ-LYDLLEKEVDAKK---------- 287
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1770 ELKKEQDT-SAHLERMKKNMEQTIKDLQH-----RLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMR 1843
Cdd:pfam06160  288 YVEKNLPEiEDYLEHAEEQNKELKEELERvqqsyTLNENELERVRGLEKQLEELEKRYDEIVERLEEKEVAYSELQEELE 367
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1844 KSERRIKELTYQTEEDKKNLMRL-------QDLVDKLQLKVKAYKRQAE----------------EAEEQANTNLSKFRK 1900
Cdd:pfam06160  368 EILEQLEEIEEEQEEFKESLQSLrkdeleaREKLDEFKLELREIKRLVEksnlpglpesyldyffDVSDEIEDLADELNE 447
                          490       500
                   ....*....|....*....|....*....
gi 6754774    1901 VQHELDEAEERADIAESQVNKLRAKSRDI 1929
Cdd:pfam06160  448 VPLNMDEVNRLLDEAQDDVDTLYEKTEEL 476
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
841-1057 3.65e-07

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 54.77  E-value: 3.65e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   841 LLKSAETEKEMANMKEEFGRVKDALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKIQLEAK 920
Cdd:COG4942   12 ALAAAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKE 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   921 VKEMTERLEDEEEMNAELTAKKRKLEDECS-------------------------ELKKDIDDLELTLAKVEKEKHATEN 975
Cdd:COG4942   92 IAELRAELEAQKEELAELLRALYRLGRQPPlalllspedfldavrrlqylkylapARREQAEELRADLAELAALRAELEA 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   976 KVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKSKVKLEQQVDDLEGSLEQ--EKKVRMDLERA 1053
Cdd:COG4942  172 ERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAaaERTPAAGFAAL 251

                 ....
gi 6754774  1054 KRKL 1057
Cdd:COG4942  252 KGKL 255
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
833-1326 3.71e-07

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 55.44  E-value: 3.71e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     833 KLYFKIKPLLKSAETEKEMANMKEEFGRVKDALEKSE--ARRKELEEKMVSLLQEKNDL------QLQVQAEQDNLNDAE 904
Cdd:TIGR00606  455 ELKFVIKELQQLEGSSDRILELDQELRKAERELSKAEknSLTETLKKEVKSLQNEKADLdrklrkLDQEMEQLNHHTTTR 534
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     905 ERCDQLIKNKIQLEAKVKEMTERLEDEEEMNAELTAKKRKLEDECSELKKDID-------DLELTLAKVEKEKHATENKV 977
Cdd:TIGR00606  535 TQMEMLTKDKMDKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINqtrdrlaKLNKELASLEQNKNHINNEL 614
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     978 KNLTEEMAGLDEIIAKLTKekkalQEAHQQALDDLQAEEDKVNTLTKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKL 1057
Cdd:TIGR00606  615 ESKEEQLSSYEDKLFDVCG-----SQDEESDLERLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQT 689
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1058 EGDLkltQESIMDLENDKLQLEEKLKKKEFDISQQNSKIEDEQALALQLQKKLKENQARIeeleeeleaeRTARAKVEKL 1137
Cdd:TIGR00606  690 EAEL---QEFISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLAPGRQSIIDLKEKEI----------PELRNKLQKV 756
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1138 RSDLSRELEEISERlEEAGGATSVQIEMNKKREAEFQKMRRdLEEATLQHEataaalrKKHADSVAELgeQIDNLQRVKQ 1217
Cdd:TIGR00606  757 NRDIQRLKNDIEEQ-ETLLGTIMPEEESAKVCLTDVTIMER-FQMELKDVE-------RKIAQQAAKL--QGSDLDRTVQ 825
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1218 KLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANE---YRVKLEEAQRSLNDFTTQRAKLQTENGELARQLE 1294
Cdd:TIGR00606  826 QVNQEKQEKQHELDTVVSKIELNRKLIQDQQEQIQHLKSKTNElksEKLQIGTNLQRRQQFEEQLVELSTEVQSLIREIK 905
                          490       500       510
                   ....*....|....*....|....*....|..
gi 6754774    1295 EKEALISQLTRGKLSYTQQMEDLKRQLEEEGK 1326
Cdd:TIGR00606  906 DAKEQDSPLETFLEKDQQEKEELISSKETSNK 937
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
842-1058 4.32e-07

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 55.02  E-value: 4.32e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   842 LKSAETEKEMANMKEEFGRVKDALEKSEARRKELEEKMVSLlqeknDLQLQVQAEQDNLNDAEERCDQLIKNKIQLEAKV 921
Cdd:COG3206  168 LRREEARKALEFLEEQLPELRKELEEAEAALEEFRQKNGLV-----DLSEEAKLLLQQLSELESQLAEARAELAEAEARL 242
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   922 KEMTERLEDEEEMNAELTAkkrklEDECSELKKDIDDLELTLAkvEKEKHATEN--KVKNLTEEMAGLdeiiakltkeKK 999
Cdd:COG3206  243 AALRAQLGSGPDALPELLQ-----SPVIQQLRAQLAELEAELA--ELSARYTPNhpDVIALRAQIAAL----------RA 305
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 6754774  1000 ALQEAHQQALDDLQAEedkVNTLTKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLE 1058
Cdd:COG3206  306 QLQQEAQRILASLEAE---LEALQAREASLQAQLAQLEARLAELPELEAELRRLEREVE 361
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1358-1777 4.33e-07

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 55.16  E-value: 4.33e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1358 ELQRVLSKANSEVAQWRTKYET--DAIQRTEELEEAKKKLAQRLQDAEEAVEAVnakcsSLEKTKHRLQNEIEDLMVDVE 1435
Cdd:COG4717   75 ELEEELKEAEEKEEEYAELQEEleELEEELEELEAELEELREELEKLEKLLQLL-----PLYQELEALEAELAELPERLE 149
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1436 RSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSlstELFKLKNAYEESLEHLETFKRENKNLQEEISDLT 1515
Cdd:COG4717  150 ELEERLEELRELEEELEELEAELAELQEELEELLEQLSLATEE---ELQDLAEELEELQQRLAELEEELEEAQEELEELE 226
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1516 EQLgEGGKNVHELEKIRKQLEVEK---------LELQSALEEAEASLEHEEGKI-LRAQLEFNQIKAEIERKLAEKDEEM 1585
Cdd:COG4717  227 EEL-EQLENELEAAALEERLKEARlllliaaalLALLGLGGSLLSLILTIAGVLfLVLGLLALLFLLLAREKASLGKEAE 305
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1586 EQAKRNHLRMVDSLQTSLDAETRSRNEALrvKKKMEGDLNEMEIQLSQANRIASEAQKHLKNSQAHLKDTQLQLDDAVHA 1665
Cdd:COG4717  306 ELQALPALEELEEEELEELLAALGLPPDL--SPEELLELLDRIEELQELLREAEELEEELQLEELEQEIAALLAEAGVED 383
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1666 NDDLKENIAIVERRNNL----------LQAELEELRAVVEQTERSR-----KLAEQELIETSERVQLLHSQNTSLINQKK 1730
Cdd:COG4717  384 EEELRAALEQAEEYQELkeeleeleeqLEELLGELEELLEALDEEEleeelEELEEELEELEEELEELREELAELEAELE 463
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*....
gi 6754774  1731 KMESD--LTQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDT 1777
Cdd:COG4717  464 QLEEDgeLAELLQELEELKAELRELAEEWAALKLALELLEEAREEYREE 512
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
865-1035 5.15e-07

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 53.00  E-value: 5.15e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   865 LEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKIQLEAKVKEMTERLE-DEEEMNAELTAKkr 943
Cdd:COG1579   12 LQELDSELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKkYEEQLGNVRNNK-- 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   944 kledECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKvntLT 1023
Cdd:COG1579   90 ----EYEALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEE---LE 162
                        170
                 ....*....|..
gi 6754774  1024 KSKVKLEQQVDD 1035
Cdd:COG1579  163 AEREELAAKIPP 174
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1256-1457 6.49e-07

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 54.00  E-value: 6.49e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1256 DQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHAL 1335
Cdd:COG4942   20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAEL 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1336 QSSRHD-CDLLREQYeeEMEAKAELQRVLSKANSEVAQWRTKY----------ETDAIQRT-EELEEAKKKLAQRLQDAE 1403
Cdd:COG4942  100 EAQKEElAELLRALY--RLGRQPPLALLLSPEDFLDAVRRLQYlkylaparreQAEELRADlAELAALRAELEAERAELE 177
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 6754774  1404 EAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAE 1457
Cdd:COG4942  178 ALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIAR 231
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
837-1186 9.36e-07

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 54.35  E-value: 9.36e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     837 KIKPLLKSAETEKEM-ANMKEEFGRVKDALEKSE-------------ARRKELEEKMVSLLQEKNDLQLQ----VQAEQD 898
Cdd:pfam15921  462 KVSSLTAQLESTKEMlRKVVEELTAKKMTLESSErtvsdltaslqekERAIEATNAEITKLRSRVDLKLQelqhLKNEGD 541
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     899 NLNDAEERCDQLiknKIQLEAK---VKEMTERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATEN 975
Cdd:pfam15921  542 HLRNVQTECEAL---KLQMAEKdkvIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEINDRRLELQEFKILKDKKDA 618
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     976 KVKNLTEEMAGLDEIIAKLT-------KEKKALQEAHQQALDDLQAEEDKVNTLTKSKVKLEQQVDDLEGSLEQ-EKKVR 1047
Cdd:pfam15921  619 KIRELEARVSDLELEKVKLVnagserlRAVKDIKQERDQLLNEVKTSRNELNSLSEDYEVLKRNFRNKSEEMETtTNKLK 698
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1048 MDLERAKRKLE---GDLKLTQESIMDLENDKLQLEEKLKKKEFDISQQNSKIED-EQALALQLQKK--LKENQARIEELE 1121
Cdd:pfam15921  699 MQLKSAQSELEqtrNTLKSMEGSDGHAMKVAMGMQKQITAKRGQIDALQSKIQFlEEAMTNANKEKhfLKEEKNKLSQEL 778
                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6754774    1122 EELEAERTARA-KVEKLRSDlSRELEEISERLEEAGGATSVQ------IEMNKKREAEFQKMRRDLEEATLQ 1186
Cdd:pfam15921  779 STVATEKNKMAgELEVLRSQ-ERRLKEKVANMEVALDKASLQfaecqdIIQRQEQESVRLKLQHTLDVKELQ 849
PRK04778 PRK04778
septation ring formation regulator EzrA; Provisional
848-1285 1.11e-06

septation ring formation regulator EzrA; Provisional


Pssm-ID: 179877 [Multi-domain]  Cd Length: 569  Bit Score: 53.69  E-value: 1.11e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    848 EKEMANMKEEFGRVKDALEKSEARRKELEEKMVSLLQEKNDLqlqVQAEQDN---LNDAEERCDQLIKNKI--------- 915
Cdd:PRK04778   90 EAEELNDKFRFRKAKHEINEIESLLDLIEEDIEQILEELQEL---LESEEKNreeVEQLKDLYRELRKSLLanrfsfgpa 166
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    916 --QLEAKVKEMTERLEDEEEMNAE---LTAKK--RKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKN----LTEEM 984
Cdd:PRK04778  167 ldELEKQLENLEEEFSQFVELTESgdyVEAREilDQLEEELAALEQIMEEIPELLKELQTELPDQLQELKAgyreLVEEG 246
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    985 AGLDEIiaKLTKEKKALQEAHQQALDDLQAEE-DKVNTLTKskvKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKL 1063
Cdd:PRK04778  247 YHLDHL--DIEKEIQDLKEQIDENLALLEELDlDEAEEKNE---EIQERIDQLYDILEREVKARKYVEKNSDTLPDFLEH 321
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1064 TQEsimdlENDKLQLEEKLKKKEFDISqqnskiEDEQALALQLQKKLKENQARIEELEEELeaertarAKVEKLRSDLSR 1143
Cdd:PRK04778  322 AKE-----QNKELKEEIDRVKQSYTLN------ESELESVRQLEKQLESLEKQYDEITERI-------AEQEIAYSELQE 383
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1144 ELEEISERLEEAggatsvqiemnKKREAEFQKMRRDLEEATLQHEATAAALRKKhadsvaelgeqidnLQRVKQKLEKEK 1223
Cdd:PRK04778  384 ELEEILKQLEEI-----------EKEQEKLSEMLQGLRKDELEAREKLERYRNK--------------LHEIKRYLEKSN 438
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6754774   1224 -----SEFKLELDDVTSNMEQiikakanlekvsrtLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTE 1285
Cdd:PRK04778  439 lpglpEDYLEMFFEVSDEIEA--------------LAEELEEKPINMEAVNRLLEEATEDVETLEEE 491
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
864-1569 1.31e-06

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 53.67  E-value: 1.31e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     864 ALEKSEARRKE-LEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKIQLEAKVKEMTERLEDEEEMNAELTAKK 942
Cdd:pfam10174   46 ALRKEEAARISvLKEQYRVTQEENQHLQLTIQALQDELRAQRDLNQLLQQDFTTSPVDGEDKFSTPELTEENFRRLQSEH 125
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     943 RKLEDECSELKKDIDDLELtlaKVEKEKHATENKvknlteemaglDEIIAKLtkekkaLQEAHQQALDDLQAEEDkvNTL 1022
Cdd:pfam10174  126 ERQAKELFLLRKTLEEMEL---RIETQKQTLGAR-----------DESIKKL------LEMLQSKGLPKKSGEED--WER 183
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1023 TKSKVKLEQQVDDLEGSLEQEKKVRMDL-ERAKRKLEG--------------DLKLTQESIMDLENDKLQLEEKLKKKEF 1087
Cdd:pfam10174  184 TRRIAEAEMQLGHLEVLLDQKEKENIHLrEELHRRNQLqpdpaktkalqtviEMKDTKISSLERNIRDLEDEVQMLKTNG 263
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1088 DISQQNSKIEDEQALALQLQKKLKENqarieeleeeleaertaraKVEKLRSDLSR---ELEEISERLEEAGGATS---V 1161
Cdd:pfam10174  264 LLHTEDREEEIKQMEVYKSHSKFMKN-------------------KIDQLKQELSKkesELLALQTKLETLTNQNSdckQ 324
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1162 QIEMNKKREAEfqkmrRDLEEATLQHEATAAALRKKHADSVaeLGEQIDNLQRvkqkLEKEKSEFKLELDDVtSNMEQII 1241
Cdd:pfam10174  325 HIEVLKESLTA-----KEQRAAILQTEVDALRLRLEEKESF--LNKKTKQLQD----LTEEKSTLAGEIRDL-KDMLDVK 392
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1242 KAKAN-LEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLtrgklsyTQQMEDLKRQ 1320
Cdd:pfam10174  393 ERKINvLQKKIENLQEQLRDKDKQLAGLKERVKSLQTDSSNTDTALTTLEEALSEKERIIERL-------KEQREREDRE 465
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1321 LEEEgkaKNALAHALQSSRHDCDLLREQYEEEMEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKK-----KL 1395
Cdd:pfam10174  466 RLEE---LESLKKENKDLKEKVSALQPELTEKESSLIDLKEHASSLASSGLKKDSKLKSLEIAVEQKKEECSKlenqlKK 542
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1396 AQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKE 1475
Cdd:pfam10174  543 AHNAEEAVRTNPEINDRIRLLEQEVARYKEESGKAQAEVERLLGILREVENEKNDKDKKIAELESLTLRQMKEQNKKVAN 622
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1476 ARSLSTELfKLKNAYEESLEHLETFKRENKNLQEEISDLTEqlgeggknvhELEKIRKQLEVEKLEL---QSALEEAEA- 1551
Cdd:pfam10174  623 IKHGQQEM-KKKGAQLLEEARRREDNLADNSQQLQLEELMG----------ALEKTRQELDATKARLsstQQSLAEKDGh 691
                          730       740
                   ....*....|....*....|
gi 6754774    1552 --SLEHEEGKILRAQLEFNQ 1569
Cdd:pfam10174  692 ltNLRAERRKQLEEILEMKQ 711
mukB PRK04863
chromosome partition protein MukB;
849-1183 1.62e-06

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 53.42  E-value: 1.62e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    849 KEMANMKEEFGRVKDALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQliKNKI-QLEAKVKEMTER 927
Cdd:PRK04863  286 EEALELRRELYTSRRQLAAEQYRLVEMARELAELNEAESDLEQDYQAASDHLNLVQTALRQ--QEKIeRYQADLEELEER 363
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    928 LEDEE-------EMNAELTAKKRKLEDECSELKKDIDDL-------------------------------ELTLAKVEKE 969
Cdd:PRK04863  364 LEEQNevveeadEQQEENEARAEAAEEEVDELKSQLADYqqaldvqqtraiqyqqavqalerakqlcglpDLTADNAEDW 443
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    970 KHATENKVKNLTEEMAGL-------DEIIAKLTKEKKALQ---------EAHQQALDDL-QAEEDKVntLTKSKVKLEQQ 1032
Cdd:PRK04863  444 LEEFQAKEQEATEELLSLeqklsvaQAAHSQFEQAYQLVRkiagevsrsEAWDVARELLrRLREQRH--LAEQLQQLRMR 521
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1033 VDDLEGSLEQEKkvrmDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKkkefDISQQnskIEDEQALALQLQKKLKE 1112
Cdd:PRK04863  522 LSELEQRLRQQQ----RAERLLAEFCKRLGKNLDDEDELEQLQEELEARLE----SLSES---VSEARERRMALRQQLEQ 590
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6754774   1113 NQARIEELEEELEAERTARAKVEKLRSDLSRELEEiSERLEEaggatsvQIEMNKKREAEFQKMRRDLEEA 1183
Cdd:PRK04863  591 LQARIQRLAARAPAWLAAQDALARLREQSGEEFED-SQDVTE-------YMQQLLERERELTVERDELAAR 653
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
845-1015 1.66e-06

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 51.46  E-value: 1.66e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   845 AETEKEMANMKEEFGRVKDALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKiQLEAKVKEM 924
Cdd:COG1579   20 DRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLGNVRNNK-EYEALQKEI 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   925 terledeeemnAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKhatENKVKNLTEEMAGLDEIIAKLTKEKKALQEA 1004
Cdd:COG1579   99 -----------ESLKRRISDLEDEILELMERIEELEEELAELEAEL---AELEAELEEKKAELDEELAELEAELEELEAE 164
                        170
                 ....*....|.
gi 6754774  1005 HQQALDDLQAE 1015
Cdd:COG1579  165 REELAAKIPPE 175
PRK04778 PRK04778
septation ring formation regulator EzrA; Provisional
1448-1922 1.75e-06

septation ring formation regulator EzrA; Provisional


Pssm-ID: 179877 [Multi-domain]  Cd Length: 569  Bit Score: 52.92  E-value: 1.75e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1448 QRNFDKI---LAEWKQKYeesqselessqkEARSLSTELFKLKNAY--EESLEHLETFKRENknlqEEISDlteqlgegg 1522
Cdd:PRK04778   24 RKRNYKRideLEERKQEL------------ENLPVNDELEKVKKLNltGQSEEKFEEWRQKW----DEIVT--------- 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1523 knvHELEKIRKQL-EVEKL-------ELQSALEEAEASLEHEEGKILRAQLEFNQIKaEIERKLaekDEEMEQAKRNHlr 1594
Cdd:PRK04778   79 ---NSLPDIEEQLfEAEELndkfrfrKAKHEINEIESLLDLIEEDIEQILEELQELL-ESEEKN---REEVEQLKDLY-- 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1595 mvDSLQTSLDAETRSRNEALrvkKKMEGDLNEMEIQLSQANRIAS-----EAQKHLKNSQAHLKDTQLQLDDavhanddl 1669
Cdd:PRK04778  150 --RELRKSLLANRFSFGPAL---DELEKQLENLEEEFSQFVELTEsgdyvEAREILDQLEEELAALEQIMEE-------- 216
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1670 kenI-AIVERRNNLLQAELEELRAVVEQ-TERSRKLAEQELIETSERVQLLHSQNTSLINQK--KKMESDLTQLQTEVE- 1744
Cdd:PRK04778  217 ---IpELLKELQTELPDQLQELKAGYRElVEEGYHLDHLDIEKEIQDLKEQIDENLALLEELdlDEAEEKNEEIQERIDq 293
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1745 -----EAVQECRNAEEKAKKAITDAAMMAEELKKEqdTSAHLERMKKN-------------MEQTIKDLQHRLDEAEQiA 1806
Cdd:PRK04778  294 lydilEREVKARKYVEKNSDTLPDFLEHAKEQNKE--LKEEIDRVKQSytlneselesvrqLEKQLESLEKQYDEITE-R 370
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1807 LKGGKKQLQKLEARVRELENEL---EAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLMRlqdLVDKLQL-----KVK 1878
Cdd:PRK04778  371 IAEQEIAYSELQEELEEILKQLeeiEKEQEKLSEMLQGLRKDELEAREKLERYRNKLHEIKR---YLEKSNLpglpeDYL 447
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*...
gi 6754774   1879 AYKRQAEEAEEQANTNLSKFR----KVQHELDEAEERADIAESQVNKL 1922
Cdd:PRK04778  448 EMFFEVSDEIEALAEELEEKPinmeAVNRLLEEATEDVETLEEETEEL 495
mukB PRK04863
chromosome partition protein MukB;
982-1870 1.85e-06

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 53.42  E-value: 1.85e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    982 EEMAGLDEIIAKLTKEK---KALQEAHQQALDDLQAEEDkvnTLTKSKVKLEQQVDDLEGSL----------EQEKKVRM 1048
Cdd:PRK04863  279 NERRVHLEEALELRRELytsRRQLAAEQYRLVEMARELA---ELNEAESDLEQDYQAASDHLnlvqtalrqqEKIERYQA 355
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1049 DLERAKRKLEGDLKLTQESimdlENDKLQLEEKLKKKEFDISQQNSKIED-EQALALQLQKKLKENQARieeleeeleae 1127
Cdd:PRK04863  356 DLEELEERLEEQNEVVEEA----DEQQEENEARAEAAEEEVDELKSQLADyQQALDVQQTRAIQYQQAV----------- 420
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1128 rTARAKVEKLRSDLSRELEEISERLEEAggATSVQIEMNKKREAEfQKMRrDLEEATLQHEATAAALRKkhadsvaeLGE 1207
Cdd:PRK04863  421 -QALERAKQLCGLPDLTADNAEDWLEEF--QAKEQEATEELLSLE-QKLS-VAQAAHSQFEQAYQLVRK--------IAG 487
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1208 QID--NLQRVKQKLEKEKSEFKLELddvtsnmEQIIKAKANLEKVSRTLEDQANeyrvkleeAQRSLNDFTtQRAKLQTE 1285
Cdd:PRK04863  488 EVSrsEAWDVARELLRRLREQRHLA-------EQLQQLRMRLSELEQRLRQQQR--------AERLLAEFC-KRLGKNLD 551
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1286 NGELARQL-EEKEALISQLTRGKLSYTQQMEDLKRQLEEegkaknalahalqssrhdcdlLREQYEEeMEAKAELQRvls 1364
Cdd:PRK04863  552 DEDELEQLqEELEARLESLSESVSEARERRMALRQQLEQ---------------------LQARIQR-LAARAPAWL--- 606
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1365 KANSEVAQWRTkyetdaiQRTEELEEAKKKLAQRLQDAEEAVEAVNAKcSSLEKTKHRLQNEIEDLmvdverSNAAAAAL 1444
Cdd:PRK04863  607 AAQDALARLRE-------QSGEEFEDSQDVTEYMQQLLERERELTVER-DELAARKQALDEEIERL------SQPGGSED 672
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1445 DKKQRnfdkiLAEwkqkyeesqselessqKEARSLSTELFK---LKNA-YEESL----------EHLETFKRENKNLQEE 1510
Cdd:PRK04863  673 PRLNA-----LAE----------------RFGGVLLSEIYDdvsLEDApYFSALygparhaivvPDLSDAAEQLAGLEDC 731
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1511 ISDL------TEQLGEGGKNVHELEK------IRKQLEVEKLELQSALEEA--EASLEheegkILRAQLEfnqikaEIER 1576
Cdd:PRK04863  732 PEDLyliegdPDSFDDSVFSVEELEKavvvkiADRQWRYSRFPEVPLFGRAarEKRIE-----QLRAERE------ELAE 800
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1577 KLAEKDEEMEQAKRNHL---RMVDS-LQTSLDAE--------TRSRNEALRVKKKMEGDLNEMEIQLSQANRIASEAQKH 1644
Cdd:PRK04863  801 RYATLSFDVQKLQRLHQafsRFIGShLAVAFEADpeaelrqlNRRRVELERALADHESQEQQQRSQLEQAKEGLSALNRL 880
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1645 LKNS--------QAHLKDTQLQLDDAVHANDDLKEN---IAIVERRNNLLQA---ELEELRAVVEQTERSRKLAEQELIE 1710
Cdd:PRK04863  881 LPRLnlladetlADRVEEIREQLDEAEEAKRFVQQHgnaLAQLEPIVSVLQSdpeQFEQLKQDYQQAQQTQRDAKQQAFA 960
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1711 TSERVQLLH----SQNTSLINQkkkmESDLT-QLQTEVEEAVQECRNAEEKAKKA---ITDAAMMAEELKKEQDTsahLE 1782
Cdd:PRK04863  961 LTEVVQRRAhfsyEDAAEMLAK----NSDLNeKLRQRLEQAEQERTRAREQLRQAqaqLAQYNQVLASLKSSYDA---KR 1033
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1783 RMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAE---QKRNAES-VKGMRKSERRIKELTYQTEE 1858
Cdd:PRK04863 1034 QMLQELKQELQDLGVPADSGAEERARARRDELHARLSANRSRRNQLEKQltfCEAEMDNlTKKLRKLERDYHEMREQVVN 1113
                         970
                  ....*....|..
gi 6754774   1859 DKKNLMRLQDLV 1870
Cdd:PRK04863 1114 AKAGWCAVLRLV 1125
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
971-1225 1.88e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 52.46  E-value: 1.88e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   971 HATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKSKVKLEQQVDDLEGSLEQekkvrmdL 1050
Cdd:COG4942   16 AAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAE-------L 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1051 ERAKRKLEGDLKLTQESIMDLeNDKLQLEEKLKKKEFDISQQNSkieDEQALALQLQKKLkeNQARieeleeeleaerta 1130
Cdd:COG4942   89 EKEIAELRAELEAQKEELAEL-LRALYRLGRQPPLALLLSPEDF---LDAVRRLQYLKYL--APAR-------------- 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1131 RAKVEKLRSDLsRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKhadsVAELGEQID 1210
Cdd:COG4942  149 REQAEELRADL-AELAALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAE----LAELQQEAE 223
                        250
                 ....*....|....*
gi 6754774  1211 NLQRVKQKLEKEKSE 1225
Cdd:COG4942  224 ELEALIARLEAEAAA 238
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
845-1449 1.90e-06

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 53.42  E-value: 1.90e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   845 AETEKEMANMKEEFGRVKDALEKSEARRKELEEKmvslLQEKND-LQLQVQAEQdnLNDAEERCdqliknkiqlEAKVKE 923
Cdd:COG3096  295 FGARRQLAEEQYRLVEMARELEELSARESDLEQD----YQAASDhLNLVQTALR--QQEKIERY----------QEDLEE 358
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   924 MTERLEDEEEMNAELT-------AKKRKLEDECSELKKDIDDL-------------------------------ELTLAK 965
Cdd:COG3096  359 LTERLEEQEEVVEEAAeqlaeaeARLEAAEEEVDSLKSQLADYqqaldvqqtraiqyqqavqalekaralcglpDLTPEN 438
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   966 VEKEKHATENKVKNLTEEMAGLDE--IIAKLTKEK--KALQ------------EAHQQALD------DLQAEEDKVNTlt 1023
Cdd:COG3096  439 AEDYLAAFRAKEQQATEEVLELEQklSVADAARRQfeKAYElvckiageversQAWQTAREllrryrSQQALAQRLQQ-- 516
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1024 kskvkLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLkltqESIMDLENDKLQLEEKLKkkefDISQQnskIEDEQALA 1103
Cdd:COG3096  517 -----LRAQLAELEQRLRQQQNAERLLEEFCQRIGQQL----DAAEELEELLAELEAQLE----ELEEQ---AAEAVEQR 580
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1104 LQLQKKLKENQARIEELEEELEAERTARAKVEKLRsdlsrelEEISERLEEAGGATS-VQIEMNKKREAEFQKmrrdlEE 1182
Cdd:COG3096  581 SELRQQLEQLRARIKELAARAPAWLAAQDALERLR-------EQSGEALADSQEVTAaMQQLLEREREATVER-----DE 648
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1183 ATLQHEATAAALRKKHADSVAE------LGEQ---------------------------------IDNLQRVKQKL---- 1219
Cdd:COG3096  649 LAARKQALESQIERLSQPGGAEdprllaLAERlggvllseiyddvtledapyfsalygparhaivVPDLSAVKEQLagle 728
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1220 -------------------------------------------------------EKEKSEFKLELDDVTsnmEQIIKAK 1244
Cdd:COG3096  729 dcpedlyliegdpdsfddsvfdaeeledavvvklsdrqwrysrfpevplfgraarEKRLEELRAERDELA---EQYAKAS 805
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1245 ANLEKVSRTLED-------------------QANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTr 1305
Cdd:COG3096  806 FDVQKLQRLHQAfsqfvgghlavafapdpeaELAALRQRRSELERELAQHRAQEQQLRQQLDQLKEQLQLLNKLLPQAN- 884
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1306 gkL----SYTQQMEDLKRQLEEEGKAKNALAH-------------ALQSSRHDCDLLREQYEeemEAKAELQRVLSK--A 1366
Cdd:COG3096  885 --LladeTLADRLEELREELDAAQEAQAFIQQhgkalaqleplvaVLQSDPEQFEQLQADYL---QAKEQQRRLKQQifA 959
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1367 NSEVAQWRT--KYEtDAIQRTEELEEAKKKLAQRLQDAE-------EAVEAVNAKCS-------SLeKTKHR-------- 1422
Cdd:COG3096  960 LSEVVQRRPhfSYE-DAVGLLGENSDLNEKLRARLEQAEearrearEQLRQAQAQYSqynqvlaSL-KSSRDakqqtlqe 1037
                        810       820
                 ....*....|....*....|....*..
gi 6754774  1423 LQNEIEDLMVDVErSNAAAAALDKKQR 1449
Cdd:COG3096 1038 LEQELEELGVQAD-AEAEERARIRRDE 1063
Motor_domain cd01363
Myosin and Kinesin motor domain; Myosin and Kinesin motor domain. These ATPases belong to the ...
653-677 2.08e-06

Myosin and Kinesin motor domain; Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes. Some of the names do not match with what is given in the sequence list. This is because they are based on the current nomenclature by Kollmar/Sebe-Pedros.


Pssm-ID: 276814 [Multi-domain]  Cd Length: 170  Bit Score: 49.65  E-value: 2.08e-06
                         10        20
                 ....*....|....*....|....*
gi 6754774   653 HRENLNKLMTNLKTTHPHFVRCIIP 677
Cdd:cd01363  146 INESLNTLMNVLRATRPHFVRCISP 170
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
856-1408 2.09e-06

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 53.13  E-value: 2.09e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     856 EEFGRVKDALEKSEarrKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNK--IQLEAKVKEMTERLEDEEE 933
Cdd:TIGR01612 1111 DEINKIKDDIKNLD---QKIDHHIKALEEIKKKSENYIDEIKAQINDLEDVADKAISNDdpEEIEKKIENIVTKIDKKKN 1187
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     934 MNAELtakkRKLEDECSELKKDIDDLE---------------LTLAKVEKEKHATENKVKNLTEEMAGLDEIiakltKEK 998
Cdd:TIGR01612 1188 IYDEI----KKLLNEIAEIEKDKTSLEevkginlsygknlgkLFLEKIDEEKKKSEHMIKAMEAYIEDLDEI-----KEK 1258
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     999 KALQEAHQQALDDLQAEEDKVNT--------LTKSKVKLEQQVDDLEGSLE--QEKKVRMDLERAKRKLEGDLKLTQE-- 1066
Cdd:TIGR01612 1259 SPEIENEMGIEMDIKAEMETFNIshdddkdhHIISKKHDENISDIREKSLKiiEDFSEESDINDIKKELQKNLLDAQKhn 1338
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1067 --------------SIMDLENDKlQLEEKLKKKEFDISQQNSKIEDEQALALQLQKKLKEN------QARIEELEEELEA 1126
Cdd:TIGR01612 1339 sdinlylneianiyNILKLNKIK-KIIDEVKEYTKEIEENNKNIKDELDKSEKLIKKIKDDinleecKSKIESTLDDKDI 1417
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1127 ERTARaKVEKLRSDLSRELEEISERLEEAGGATS------VQIEMNKKREAEFQKMRRDleEATLQHEATAAALrKKHAD 1200
Cdd:TIGR01612 1418 DECIK-KIKELKNHILSEESNIDTYFKNADENNEnvlllfKNIEMADNKSQHILKIKKD--NATNDHDFNINEL-KEHID 1493
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1201 SVAELGEQIDnlqRVKQKLEKEKSEFKLELDDVTSNMEQ---------IIKAKANLEKVSRTLEDQANEYRVKLEEAQRS 1271
Cdd:TIGR01612 1494 KSKGCKDEAD---KNAKAIEKNKELFEQYKKDVTELLNKysalaiknkFAKTKKDSEIIIKEIKDAHKKFILEAEKSEQK 1570
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1272 LNDFTTQRAKLQTENGELARQ-------------LEEKEALISQLTRGKLSYTQQMEDLKRQ------------LEEEGK 1326
Cdd:TIGR01612 1571 IKEIKKEKFRIEDDAAKNDKSnkaaidiqlslenFENKFLKISDIKKKINDCLKETESIEKKissfsidsqdteLKENGD 1650
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1327 AKNALAHALQSsrhdcdlLREQYEEEMEAKAELQRVLSKANS---EVAQWRTKYETDAIQRTEELEEAKKklaQRLQDAE 1403
Cdd:TIGR01612 1651 NLNSLQEFLES-------LKDQKKNIEDKKKELDELDSEIEKieiDVDQHKKNYEIGIIEKIKEIAIANK---EEIESIK 1720

                   ....*
gi 6754774    1404 EAVEA 1408
Cdd:TIGR01612 1721 ELIEP 1725
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
862-1629 2.31e-06

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 53.13  E-value: 2.31e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     862 KDALEK--SEARRKELEEKMVSLLQEKNDLQLQVQAEQDNL------------NDAEERCDQLIKN----KIQLEAKVKE 923
Cdd:TIGR01612  976 INELDKafKDASLNDYEAKNNELIKYFNDLKANLGKNKENMlyhqfdekekatNDIEQKIEDANKNipniEIAIHTSIYN 1055
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     924 MTERLEDEEEMNAELTAKK--RKLEDECSELKKDIDDLEL----TLAKVEKEKHATE-NKVKNlteEMAGLDEIIAKLTK 996
Cdd:TIGR01612 1056 IIDEIEKEIGKNIELLNKEilEEAEINITNFNEIKEKLKHynfdDFGKEENIKYADEiNKIKD---DIKNLDQKIDHHIK 1132
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     997 EKKALQEAHQQALDDLQAEEDKVNTLTKSKVkleqQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQEsIMDLENDKL 1076
Cdd:TIGR01612 1133 ALEEIKKKSENYIDEIKAQINDLEDVADKAI----SNDDPEEIEKKIENIVTKIDKKKNIYDEIKKLLNE-IAEIEKDKT 1207
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1077 QLEEkLKKKEFDISQQNSKIEDEQalaLQLQKKLKENQARieeleeeleaertaraKVEKLRSDLSrELEEISERLEEAG 1156
Cdd:TIGR01612 1208 SLEE-VKGINLSYGKNLGKLFLEK---IDEEKKKSEHMIK----------------AMEAYIEDLD-EIKEKSPEIENEM 1266
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1157 GatsvqIEMNKKREAEFQKMRRDLEE----ATLQHEATAAALRKKHADSVAELGEQID------NLQRVKQKLEKEKSEF 1226
Cdd:TIGR01612 1267 G-----IEMDIKAEMETFNISHDDDKdhhiISKKHDENISDIREKSLKIIEDFSEESDindikkELQKNLLDAQKHNSDI 1341
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1227 KLELDDVTsNMEQIIKakanLEKVSRTLeDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGElARQLEEKEALISQLTRG 1306
Cdd:TIGR01612 1342 NLYLNEIA-NIYNILK----LNKIKKII-DEVKEYTKEIEENNKNIKDELDKSEKLIKKIKD-DINLEECKSKIESTLDD 1414
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1307 K--LSYTQQMEDLKRQ-LEEEGKA----KNA-------------LAHALQSSRHDCDLLREQYEEEMEAKA-ELQRVLSK 1365
Cdd:TIGR01612 1415 KdiDECIKKIKELKNHiLSEESNIdtyfKNAdennenvlllfknIEMADNKSQHILKIKKDNATNDHDFNInELKEHIDK 1494
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1366 ANsevaqwrtKYETDAIQRTEELEEAKKKLAQRLQDAEEAVE-----AVNAKCSSLEKTKHRLQNEIEDL----MVDVER 1436
Cdd:TIGR01612 1495 SK--------GCKDEADKNAKAIEKNKELFEQYKKDVTELLNkysalAIKNKFAKTKKDSEIIIKEIKDAhkkfILEAEK 1566
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1437 SNAAAAALDKKQRNFDKILAewkqKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLetfkRENKNLQEEISDLT- 1515
Cdd:TIGR01612 1567 SEQKIKEIKKEKFRIEDDAA----KNDKSNKAAIDIQLSLENFENKFLKISDIKKKINDCL----KETESIEKKISSFSi 1638
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1516 ----EQLGEGGKNVHELEKIRKQLEVEKlelqSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRN 1591
Cdd:TIGR01612 1639 dsqdTELKENGDNLNSLQEFLESLKDQK----KNIEDKKKELDELDSEIEKIEIDVDQHKKNYEIGIIEKIKEIAIANKE 1714
                          810       820       830       840
                   ....*....|....*....|....*....|....*....|...
gi 6754774    1592 HLRMV-DSLQTSLDAETRSRN----EALRVKKKMEGDLNEMEI 1629
Cdd:TIGR01612 1715 EIESIkELIEPTIENLISSFNtndlEGIDPNEKLEEYNTEIGD 1757
46 PHA02562
endonuclease subunit; Provisional
863-1089 2.48e-06

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 52.32  E-value: 2.48e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    863 DALEKSeaRRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEErcdqliKNKIQLEAKVKEMTERLEDEEEMNAELTakk 942
Cdd:PHA02562  169 DKLNKD--KIRELNQQIQTLDMKIDHIQQQIKTYNKNIEEQRK------KNGENIARKQNKYDELVEEAKTIKAEIE--- 237
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    943 rKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGL----------------DEIIAKLTKEKKALQ---E 1003
Cdd:PHA02562  238 -ELTDELLNLVMDIEDPSAALNKLNTAAAKIKSKIEQFQKVIKMYekggvcptctqqisegPDRITKIKDKLKELQhslE 316
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1004 AHQQALDDLQAEEDKVNTLTKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLK 1083
Cdd:PHA02562  317 KLDTAIDELEEIMDEFNEQSKKLLELKNKISTNKQSLITLVDKAKKVKAAIEELQAEFVDNAEELAKLQDELDKIVKTKS 396

                  ....*.
gi 6754774   1084 KKEFDI 1089
Cdd:PHA02562  397 ELVKEK 402
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1354-1589 3.41e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 51.69  E-value: 3.41e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1354 EAKAELQRVLSKANSEVAQwrtkyetdAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMvd 1433
Cdd:COG4942   20 DAAAEAEAELEQLQQEIAE--------LEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELE-- 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1434 vERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISD 1513
Cdd:COG4942   90 -KEIAELRAELEAQKEELAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAE 168
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6754774  1514 LTEQLGEGGKNVHELEKIRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAK 1589
Cdd:COG4942  169 LEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTP 244
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1508-1731 3.56e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 51.30  E-value: 3.56e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1508 QEEISDLTEQLGEGGKNVHELEKIRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEI---ERKLAEKDEE 1584
Cdd:COG4942   19 ADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELaelEKEIAELRAE 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1585 MEQAKRNHLRMVDSLQTSldaetrSRNEALRVKKKMEgDLNEMEIQLSQANRIASEAQKHLKNSQAHLKDTQLQLDDAVH 1664
Cdd:COG4942   99 LEAQKEELAELLRALYRL------GRQPPLALLLSPE-DFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEA 171
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6754774  1665 ANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKK 1731
Cdd:COG4942  172 ERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAA 238
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1752-1938 4.57e-06

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 51.99  E-value: 4.57e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1752 NAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEqIALKGGKKQLQKLEARVRELE---NEL 1828
Cdd:PRK03918  162 NAYKNLGEVIKEIKRRIERLEKFIKRTENIEELIKEKEKELEEVLREINEIS-SELPELREELEKLEKEVKELEelkEEI 240
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1829 EAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLMRLQDLVDKLQlKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEA 1908
Cdd:PRK03918  241 EELEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKELK-ELKEKAEEYIKLSEFYEEYLDELREIEKRLSRL 319
                         170       180       190
                  ....*....|....*....|....*....|
gi 6754774   1909 EERADIAESQVNKLRAKSRDIGAKKMHDEE 1938
Cdd:PRK03918  320 EEEINGIEERIKELEEKEERLEELKKKLKE 349
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
1393-1898 4.92e-06

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 51.56  E-value: 4.92e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1393 KKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESS 1472
Cdd:TIGR04523  207 KKKIQKNKSLESQISELKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQLSEKQKELEQNNKKIKEL 286
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1473 QKEARSLSTELFKLKNAYEESLehLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKIRKQLEVEKLELQSALEEAEAS 1552
Cdd:TIGR04523  287 EKQLNQLKSEISDLNNQKEQDW--NKELKSELKNQEKKLEEIQNQISQNNKIISQLNEQISQLKKELTNSESENSEKQRE 364
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1553 LEHEEGKILRAQLEFNQIKAEIErKLAEKDEEMEQAKRNHLRMVDSLQTSLDaetrsrnealrvKKKMEGDLNEMEIQLS 1632
Cdd:TIGR04523  365 LEEKQNEIEKLKKENQSYKQEIK-NLESQINDLESKIQNQEKLNQQKDEQIK------------KLQQEKELLEKEIERL 431
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1633 QANRIASEAQ-KHLKNSQAHLKDTQLQLDDAVhanDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIET 1711
Cdd:TIGR04523  432 KETIIKNNSEiKDLTNQDSVKELIIKNLDNTR---ESLETQLKVLSRSINKIKQNLEQKQKELKSKEKELKKLNEEKKEL 508
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1712 SERVQLLHSQNTSLINQKKKMESDLTQLQTEVeeavqecRNAEEKAKKaitdaamMAEELKKEQdtsahLERMKKNMEQT 1791
Cdd:TIGR04523  509 EEKVKDLTKKISSLKEKIEKLESEKKEKESKI-------SDLEDELNK-------DDFELKKEN-----LEKEIDEKNKE 569
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1792 IKDLQHrldeaEQIALKGGKKQLQklearvrELENELEAEQKrnaESVKGMRKSERRIKELTYQTEEDKKNLMRLQDLVD 1871
Cdd:TIGR04523  570 IEELKQ-----TQKSLKKKQEEKQ-------ELIDQKEKEKK---DLIKEIEEKEKKISSLEKELEKAKKENEKLSSIIK 634
                          490       500
                   ....*....|....*....|....*..
gi 6754774    1872 KLQLKVKAYKRQAEEAEEQANTNLSKF 1898
Cdd:TIGR04523  635 NIKSKKNKLKQEVKQIKETIKEIRNKW 661
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
1134-1426 5.03e-06

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 51.66  E-value: 5.03e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1134 VEKLRSDLSRELEEISERLEEAggatsvQIEMNKKREAEFQKMRRDLEEATLQHEAT---AAALRKKHADSVAELGEQID 1210
Cdd:pfam17380  278 VQHQKAVSERQQQEKFEKMEQE------RLRQEKEEKAREVERRRKLEEAEKARQAEmdrQAAIYAEQERMAMERERELE 351
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1211 NLQRVKQKLEKEK---SEFKLELDDVTSNMEQIIKAKANLEKVSRTLEdQANEYRVKLEEAQRSLNDFTTQRAKLQTENg 1287
Cdd:pfam17380  352 RIRQEERKRELERirqEEIAMEISRMRELERLQMERQQKNERVRQELE-AARKVKILEEERQRKIQQQKVEMEQIRAEQ- 429
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1288 ELARQL------EEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSSRHDCDLLREQYEEEMEAKAE--- 1358
Cdd:pfam17380  430 EEARQRevrrleEERAREMERVRLEEQERQQQVERLRQQEEERKRKKLELEKEKRDRKRAEEQRRKILEKELEERKQami 509
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6754774    1359 --------LQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNE 1426
Cdd:pfam17380  510 eeerkrklLEKEMEERQKAIYEEERRREAEEERRKQQEMEERRRIQEQMRKATEERSRLEAMEREREMMRQIVESE 585
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1479-1697 5.40e-06

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 51.56  E-value: 5.40e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1479 LSTELFKLKNAYEESLEHLETFKRENK--NLQEEISDLTEQLGeggknvhELEKIRKQLEVEKLELQSALEEAEASLEHE 1556
Cdd:COG3206  180 LEEQLPELRKELEEAEAALEEFRQKNGlvDLSEEAKLLLQQLS-------ELESQLAEARAELAEAEARLAALRAQLGSG 252
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1557 EGKI--LRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRMVdSLQTSLDA-ETRSRNEALRVKKKMEGDLNEMEIQLSQ 1633
Cdd:COG3206  253 PDALpeLLQSPVIQQLRAQLAELEAELAELSARYTPNHPDVI-ALRAQIAAlRAQLQQEAQRILASLEAELEALQAREAS 331
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6754774  1634 ANRIASEAQKHLKNsqahLKDTQLQLddavhanDDLKENIAIVERRNNLLQAELEELRAVVEQT 1697
Cdd:COG3206  332 LQAQLAQLEARLAE----LPELEAEL-------RRLEREVEVARELYESLLQRLEEARLAEALT 384
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
931-1426 6.66e-06

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 51.31  E-value: 6.66e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   931 EEEMNAELTAKKRKLEDECSELKKDIDDLElTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALqEAHQQALD 1010
Cdd:COG4717   52 EKEADELFKPQGRKPELNLKELKELEEELK-EAEEKEEEYAELQEELEELEEELEELEAELEELREELEKL-EKLLQLLP 129
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1011 DLQAEEDKVNTLTKSKVKLEQqvddlegsLEQEKKVRMDLERAKRKLEGDLKLTQESI-MDLENDKLQLEEKLKKKEFDI 1089
Cdd:COG4717  130 LYQELEALEAELAELPERLEE--------LEERLEELRELEEELEELEAELAELQEELeELLEQLSLATEEELQDLAEEL 201
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1090 SQQNSKIEDEQALALQLQKKLKENQARIEELeeeleaertaraKVEKLRSDLSRELEEISERLeeAGGATSVQIEMNKKR 1169
Cdd:COG4717  202 EELQQRLAELEEELEEAQEELEELEEELEQL------------ENELEAAALEERLKEARLLL--LIAAALLALLGLGGS 267
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1170 EAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVK----QKLEKEKSEFKLELDDVTSNMEQIIKAKA 1245
Cdd:COG4717  268 LLSLILTIAGVLFLVLGLLALLFLLLAREKASLGKEAEELQALPALEeleeEELEELLAALGLPPDLSPEELLELLDRIE 347
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1246 NLEKVSRTLEDQANEYRVKLEEAQRSlNDFTTQRAKLQTENGELARQLEEKEALisqltrgklsyTQQMEDLKRQLEEEG 1325
Cdd:COG4717  348 ELQELLREAEELEEELQLEELEQEIA-ALLAEAGVEDEEELRAALEQAEEYQEL-----------KEELEELEEQLEELL 415
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1326 KAKNALAHAlqssrHDCDLLREQYEEEMEAKAELQRVLSKANSEVAqwRTKYETDAIQRTEELEEAKKKLAQRLQDAEEA 1405
Cdd:COG4717  416 GELEELLEA-----LDEEELEEELEELEEELEELEEELEELREELA--ELEAELEQLEEDGELAELLQELEELKAELREL 488
                        490       500
                 ....*....|....*....|....
gi 6754774  1406 VEAVNAKC---SSLEKTKHRLQNE 1426
Cdd:COG4717  489 AEEWAALKlalELLEEAREEYREE 512
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
1670-1927 6.76e-06

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 51.60  E-value: 6.76e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1670 KENIAIVE--RRNNLLQAELEELRAVVEQ-------TERsRKLAEQELIETSERVQLLHSQNTSLINQKKKMesdltQLQ 1740
Cdd:TIGR02168  135 KRSYSIIEqgKISEIIEAKPEERRAIFEEaagiskyKER-RKETERKLERTRENLDRLEDILNELERQLKSL-----ERQ 208
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1741 TEVEEAVQECRNAEEKAKKAItdAAMMAEELKKEQDTsahLERMKKNMEQTIKDLQHRLDEAEQialkggkkQLQKLEAR 1820
Cdd:TIGR02168  209 AEKAERYKELKAELRELELAL--LVLRLEELREELEE---LQEELKEAEEELEELTAELQELEE--------KLEELRLE 275
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1821 VRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLMRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRK 1900
Cdd:TIGR02168  276 VSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELES 355
                          250       260
                   ....*....|....*....|....*..
gi 6754774    1901 VQHELDEAEERADIAESQVNKLRAKSR 1927
Cdd:TIGR02168  356 LEAELEELEAELEELESRLEELEEQLE 382
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
957-1369 6.91e-06

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 51.38  E-value: 6.91e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     957 DDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDL-------QAEEDKVN-TLTKSKVK 1028
Cdd:pfam12128  600 EELRERLDKAEEALQSAREKQAAAEEQLVQANGELEKASREETFARTALKNARLDLrrlfdekQSEKDKKNkALAERKDS 679
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1029 LEQQVDDLEGsleQEKKVRMDLERAKRKLEGDLKltqESIMDLENDKLQLEEKLKKKEFDISQQnskIEDEQALALQLQK 1108
Cdd:pfam12128  680 ANERLNSLEA---QLKQLDKKHQAWLEEQKEQKR---EARTEKQAYWQVVEGALDAQLALLKAA---IAARRSGAKAELK 750
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1109 KLKENQARieeleeeleaERTARAKVEKLRSDLSRELEEISERLEEAggatsvqiemnKKREAEFQKMRRDLEEATLQHE 1188
Cdd:pfam12128  751 ALETWYKR----------DLASLGVDPDVIAKLKREIRTLERKIERI-----------AVRRQEVLRYFDWYQETWLQRR 809
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1189 ----ATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEqiiKAKANLEKVSRTLEDQ-ANEYRV 1263
Cdd:pfam12128  810 prlaTQLSNIERAISELQQQLARLIADTKLRRAKLEMERKASEKQQVRLSENLR---GLRCEMSKLATLKEDAnSEQAQG 886
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1264 KLEEAQRSLNDFttqRAKLQTENGELARQLEEKEALISQLTRGKLSYTqqMEDLKRQLEEEGKAKNALAHALQSSRHDCD 1343
Cdd:pfam12128  887 SIGERLAQLEDL---KLKRDYLSESVKKYVEHFKNVIADHSGSGLAET--WESLREEDHYQNDKGIRLLDYRKLVPYLEQ 961
                          410       420
                   ....*....|....*....|....*.
gi 6754774    1344 LLREQYEEEMEAKAELQRVLSKANSE 1369
Cdd:pfam12128  962 WFDVRVPQSIMVLREQVSILGVDLTE 987
mukB PRK04863
chromosome partition protein MukB;
1258-1930 7.07e-06

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 51.50  E-value: 7.07e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1258 ANEYRVKLEEA---QRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTrgklsytQQMEDLKRQLEeegKAKNALAHA 1334
Cdd:PRK04863  278 ANERRVHLEEAlelRRELYTSRRQLAAEQYRLVEMARELAELNEAESDLE-------QDYQAASDHLN---LVQTALRQQ 347
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1335 LQSSRHDCDL--LREQYEEEMEA-------KAELQRVLSKANSEVAQWRTKY----------ETDAIQ------------ 1383
Cdd:PRK04863  348 EKIERYQADLeeLEERLEEQNEVveeadeqQEENEARAEAAEEEVDELKSQLadyqqaldvqQTRAIQyqqavqalerak 427
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1384 ----------------------RTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKtkhrlqneiedLMVDVERSNAAA 1441
Cdd:PRK04863  428 qlcglpdltadnaedwleefqaKEQEATEELLSLEQKLSVAQAAHSQFEQAYQLVRK-----------IAGEVSRSEAWD 496
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1442 AALDK-----KQRNFDKILAEWKQKYEESQSELESSqKEARSLSTELFKLKNAYEESLEHLETFKREnknLQEEISDLTE 1516
Cdd:PRK04863  497 VARELlrrlrEQRHLAEQLQQLRMRLSELEQRLRQQ-QRAERLLAEFCKRLGKNLDDEDELEQLQEE---LEARLESLSE 572
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1517 QLGEGGKNVHELEKIRKQL--EVEKLELQS-ALEEAEASLEHeegkiLRAQ-----------LEFNQIKAEIERKLAEKD 1582
Cdd:PRK04863  573 SVSEARERRMALRQQLEQLqaRIQRLAARApAWLAAQDALAR-----LREQsgeefedsqdvTEYMQQLLERERELTVER 647
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1583 EEMEQAKRNHLRMVDSLQTSLDAE-TRSRNEALRVKKKMEGDLNEmEIQLSQANRIA---------------SEAQKHLK 1646
Cdd:PRK04863  648 DELAARKQALDEEIERLSQPGGSEdPRLNALAERFGGVLLSEIYD-DVSLEDAPYFSalygparhaivvpdlSDAAEQLA 726
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1647 NSQAHLKDTQL------QLDDAVHANDDLKENI----------------------AIVERRNNLLQAELEELravveqTE 1698
Cdd:PRK04863  727 GLEDCPEDLYLiegdpdSFDDSVFSVEELEKAVvvkiadrqwrysrfpevplfgrAAREKRIEQLRAEREEL------AE 800
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1699 RSRKLAEQelietSERVQLLHSQNTSLINQKKKM------ESDLTQLQT---EVEEAVQECRNAEEKAKKAITDAAMMAE 1769
Cdd:PRK04863  801 RYATLSFD-----VQKLQRLHQAFSRFIGSHLAVafeadpEAELRQLNRrrvELERALADHESQEQQQRSQLEQAKEGLS 875
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1770 ELKKEQDTSAHLERmkKNMEQTIKDLQHRLDEAEQ----IALKGGK-KQLQKLEARVRELENELEAEQKRNAESVKGMRK 1844
Cdd:PRK04863  876 ALNRLLPRLNLLAD--ETLADRVEEIREQLDEAEEakrfVQQHGNAlAQLEPIVSVLQSDPEQFEQLKQDYQQAQQTQRD 953
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1845 SERRIKELTY--------QTEEDKKNLMRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAE 1916
Cdd:PRK04863  954 AKQQAFALTEvvqrrahfSYEDAAEMLAKNSDLNEKLRQRLEQAEQERTRAREQLRQAQAQLAQYNQVLASLKSSYDAKR 1033
                         810
                  ....*....|....
gi 6754774   1917 SQVNKLRAKSRDIG 1930
Cdd:PRK04863 1034 QMLQELKQELQDLG 1047
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
1341-1911 7.51e-06

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 51.26  E-value: 7.51e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1341 DCDLLREQYEEEMEAKAELQRVLSKANSE---VAQWRTKYETDAIQRTEELEE------AKKKLAQRLQDAEEAV----E 1407
Cdd:pfam05483   58 DCHYQEGLKDSDFENSEGLSRLYSKLYKEaekIKKWKVSIEAELKQKENKLQEnrkiieAQRKAIQELQFENEKVslklE 137
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1408 AVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTEL-FKL 1486
Cdd:pfam05483  138 EEIQENKDLIKENNATRHLCNLLKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMILAFEELRVQAENARLEMhFKL 217
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1487 KNAYEEsLEHLET-FKRENKNLQEEISDLTEQLGEGGKNVHELEKIRKQL--EVEKLELQSALEEAEASLEHEEGKILRA 1563
Cdd:pfam05483  218 KEDHEK-IQHLEEeYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESrdKANQLEEKTKLQDENLKELIEKKDHLTK 296
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1564 QLEfnQIKAEIERKLAEK---DEEMEQAKRNHLRMVDSLQTSLDAETRSRNEALRVkkkmegdLNEMEIQLSQANRIASE 1640
Cdd:pfam05483  297 ELE--DIKMSLQRSMSTQkalEEDLQIATKTICQLTEEKEAQMEELNKAKAAHSFV-------VTEFEATTCSLEELLRT 367
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1641 AQKHLKNSQAHLKDTQLQLDDAvhaNDDLKEniaiVERRNNLLQAELEELRAVVeqTERSRKLAEQELIET-SERVQLLH 1719
Cdd:pfam05483  368 EQQRLEKNEDQLKIITMELQKK---SSELEE----MTKFKNNKEVELEELKKIL--AEDEKLLDEKKQFEKiAEELKGKE 438
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1720 SQNTSLINQKKK----MESDLTQLQT-------EVEEAVQECRNAEEKAKKAITDAAMMAEELKK-EQDTSAHLERMKKN 1787
Cdd:pfam05483  439 QELIFLLQAREKeihdLEIQLTAIKTseehylkEVEDLKTELEKEKLKNIELTAHCDKLLLENKElTQEASDMTLELKKH 518
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1788 MEqtikDLQHRLDEAEQIAlkggkKQLQKLEARVRELENELEA---EQKRNAESVK-GMRKSERRIKELTYQTEEDKKNL 1863
Cdd:pfam05483  519 QE----DIINCKKQEERML-----KQIENLEEKEMNLRDELESvreEFIQKGDEVKcKLDKSEENARSIEYEVLKKEKQM 589
                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6754774    1864 MRLQDL--------------VDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEER 1911
Cdd:pfam05483  590 KILENKcnnlkkqienknknIEELHQENKALKKKGSAENKQLNAYEIKVNKLELELASAKQK 651
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1155-1384 7.73e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 50.53  E-value: 7.73e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1155 AGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAAlRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVT 1234
Cdd:COG4942   11 LALAAAAQADAAAEAEAELEQLQQEIAELEKELAALKKE-EKALLKQLAALERRIAALARRIRALEQELAALEAELAELE 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1235 SNMEQIIKA----KANLEKVSRTLEDQANEYRVKL-------EEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQL 1303
Cdd:COG4942   90 KEIAELRAEleaqKEELAELLRALYRLGRQPPLALllspedfLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAEL 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1304 TRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSSRHDCDLLREQYEEEMEAKAELQRVLSKANSEVAQWRTKYETDAIQ 1383
Cdd:COG4942  170 EAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPAAGFA 249

                 .
gi 6754774  1384 R 1384
Cdd:COG4942  250 A 250
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
1253-1411 8.25e-06

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 49.15  E-value: 8.25e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1253 TLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAK--NA 1330
Cdd:COG1579   14 ELDSELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLGNVRNNKeyEA 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1331 LAHALQSSRHDCDLLREQYEEEMEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVN 1410
Cdd:COG1579   94 LQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELEAEREELAAKIP 173

                 .
gi 6754774  1411 A 1411
Cdd:COG1579  174 P 174
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1474-1934 8.32e-06

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 50.92  E-value: 8.32e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1474 KEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKIRKQLEVEKLELQSALEEAEASL 1553
Cdd:COG4717   53 KEADELFKPQGRKPELNLKELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQLLPLYQ 132
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1554 EheegkilraqlefnqiKAEIERKLAEKDEEMEQAKRNHlrmvdslqtsldaetRSRNEALRVKKKMEGDLNEMEIQLSQ 1633
Cdd:COG4717  133 E----------------LEALEAELAELPERLEELEERL---------------EELRELEEELEELEAELAELQEELEE 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1634 ANRIASEAQKHlknsqaHLKDTQLQLDDAVHANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSE 1713
Cdd:COG4717  182 LLEQLSLATEE------ELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERLKEARLLLLIA 255
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1714 RVQLLHSQNTSLINQKKKMESDLTQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKK--EQDTSAHLERMKKNMEQT 1791
Cdd:COG4717  256 AALLALLGLGGSLLSLILTIAGVLFLVLGLLALLFLLLAREKASLGKEAEELQALPALEEleEEELEELLAALGLPPDLS 335
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1792 IKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAE-QKRNAESVKGMRKS----------ERRIKELTYQTEEDK 1860
Cdd:COG4717  336 PEELLELLDRIEELQELLREAEELEEELQLEELEQEIAALlAEAGVEDEEELRAAleqaeeyqelKEELEELEEQLEELL 415
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1861 KNLMRLQDLVDKLQLKVKA--YKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIA------ESQVNKLRAKSRDIGAK 1932
Cdd:COG4717  416 GELEELLEALDEEELEEELeeLEEELEELEEELEELREELAELEAELEQLEEDGELAellqelEELKAELRELAEEWAAL 495

                 ..
gi 6754774  1933 KM 1934
Cdd:COG4717  496 KL 497
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
1474-1619 1.04e-05

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 48.77  E-value: 1.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1474 KEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDL-------TEQLGEGGKN------VHELEKIRKQ---LEV 1537
Cdd:COG1579   31 AELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVearikkyEEQLGNVRNNkeyealQKEIESLKRRisdLED 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1538 EKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNhlrmVDSLQTSLDAETRSRNEALRVK 1617
Cdd:COG1579  111 EILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELEAE----REELAAKIPPELLALYERIRKR 186

                 ..
gi 6754774  1618 KK 1619
Cdd:COG1579  187 KN 188
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
887-1517 1.41e-05

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 50.44  E-value: 1.41e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     887 NDLQLQVQAEQDNLNDAEERCDQLIKNKIQLEAKVKEMTERLEDEEEMnaELTAKKRKLEDECSELKKDIDDLEltlAKV 966
Cdd:TIGR01612 1486 NELKEHIDKSKGCKDEADKNAKAIEKNKELFEQYKKDVTELLNKYSAL--AIKNKFAKTKKDSEIIIKEIKDAH---KKF 1560
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     967 EKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAhQQALDDLqaeEDKVNTLTKSKVKLEQQVDDLEGSLEQEKKV 1046
Cdd:TIGR01612 1561 ILEAEKSEQKIKEIKKEKFRIEDDAAKNDKSNKAAIDI-QLSLENF---ENKFLKISDIKKKINDCLKETESIEKKISSF 1636
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1047 RMDLERAKRKLEGDLKLT-QESIMDLENDKLQLEEKlkKKEFDisQQNSKIEdeqALALQLQKKLKENQARIEELEEEle 1125
Cdd:TIGR01612 1637 SIDSQDTELKENGDNLNSlQEFLESLKDQKKNIEDK--KKELD--ELDSEIE---KIEIDVDQHKKNYEIGIIEKIKE-- 1707
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1126 aerTARAKVEKLRSdLSRELEEISERLEEAGGATSVQ-IEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAE 1204
Cdd:TIGR01612 1708 ---IAIANKEEIES-IKELIEPTIENLISSFNTNDLEgIDPNEKLEEYNTEIGDIYEEFIELYNIIAGCLETVSKEPITY 1783
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1205 lgEQIDNLQRVKQ----KLEKEKSEFKLELDDVTSN-MEQIIKA-KANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQ 1278
Cdd:TIGR01612 1784 --DEIKNTRINAQneflKIIEIEKKSKSYLDDIEAKeFDRIINHfKKKLDHVNDKFTKEYSKINEGFDDISKSIENVKNS 1861
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1279 raklQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEeegKAKNALAHALQSSRhDCDLLREQYEE-----EM 1353
Cdd:TIGR01612 1862 ----TDENLLFDILNKTKDAYAGIIGKKYYSYKDEAEKIFINIS---KLANSINIQIQNNS-GIDLFDNINIAilsslDS 1933
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1354 EAKAELQRVLSKAN-SEV-AQWRTKYET-----DAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNE 1426
Cdd:TIGR01612 1934 EKEDTLKFIPSPEKePEIyTKIRDSYDTlldifKKSQDLHKKEQDTLNIIFENQQLYEKIQASNELKDTLSDLKYKKEKI 2013
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1427 IEDLMVDVERSNAAAAaLDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKN 1506
Cdd:TIGR01612 2014 LNDVKLLLHKFDELNK-LSCDSQNYDTILELSKQDKIKEKIDNYEKEKEKFGIDFDVKAMEEKFDNDIKDIEKFENNYKH 2092
                          650
                   ....*....|.
gi 6754774    1507 LQEEISDLTEQ 1517
Cdd:TIGR01612 2093 SEKDNHDFSEE 2103
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1474-1679 1.55e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 49.38  E-value: 1.55e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1474 KEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKIRKQLEVEKLELQSALEEAEASL 1553
Cdd:COG4942   20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAEL 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1554 EHEEGKI---LRAQLEFNQ-------IKAEIERKLAEKDEEMEQAKRNHLRMVDSLQTSLDAETRSRNEALRVKKKMEGD 1623
Cdd:COG4942  100 EAQKEELaelLRALYRLGRqpplallLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELEAL 179
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 6754774  1624 LNEMEIQLSQANRIASEAQKHLKNSQAHLKDTQLQLDDAVHANDDLKENIAIVERR 1679
Cdd:COG4942  180 LAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAE 235
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
1505-1938 1.59e-05

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 50.21  E-value: 1.59e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1505 KNLQEEISDLTEQLGEGGKNVHELEKIRKQLEVEKLELQSALE-EAEASLEHEEGKILRAQLEFNQIK-AEIERKLAEKD 1582
Cdd:pfam10174  174 KKSGEEDWERTRRIAEAEMQLGHLEVLLDQKEKENIHLREELHrRNQLQPDPAKTKALQTVIEMKDTKiSSLERNIRDLE 253
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1583 EEmeqakrnhlrmVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSQANRIASEAQKHLKNSQAHLKDTQLQLDDA 1662
Cdd:pfam10174  254 DE-----------VQMLKTNGLLHTEDREEEIKQMEVYKSHSKFMKNKIDQLKQELSKKESELLALQTKLETLTNQNSDC 322
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1663 VHANDDLKENIAIVERRNNLLQAELEELRAVVEQ-----TERSRKLAE---------------QELIETSER-VQLLHSQ 1721
Cdd:pfam10174  323 KQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEkesflNKKTKQLQDlteekstlageirdlKDMLDVKERkINVLQKK 402
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1722 NTSLINQKKKMESDLTQLQTEVEEAVQECRNAEekakkaiTDAAMMAEELKKEQDTsahLERMKknmEQTIKDLQHRLDE 1801
Cdd:pfam10174  403 IENLQEQLRDKDKQLAGLKERVKSLQTDSSNTD-------TALTTLEEALSEKERI---IERLK---EQREREDRERLEE 469
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1802 AEQI--ALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLMRLQDLVDKLQlkvka 1879
Cdd:pfam10174  470 LESLkkENKDLKEKVSALQPELTEKESSLIDLKEHASSLASSGLKKDSKLKSLEIAVEQKKEECSKLENQLKKAH----- 544
                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 6754774    1880 ykrQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDIGAKKmHDEE 1938
Cdd:pfam10174  545 ---NAEEAVRTNPEINDRIRLLEQEVARYKEESGKAQAEVERLLGILREVENEK-NDKD 599
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
1498-1853 1.70e-05

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 49.51  E-value: 1.70e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1498 ETFKRENKNLQEEISDLTEQLGEGGKNVHELEKIRKQLEVEKLELQsalEEAEASLEHEEGKILRAQLEFNQIKAEIERK 1577
Cdd:pfam07888   69 EQWERQRRELESRVAELKEELRQSREKHEELEEKYKELSASSEELS---EEKDALLAQRAAHEARIRELEEDIKTLTQRV 145
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1578 LaEKDEEMEQAKRNHLRMVDSLQtsldaETRSRNEALRVKkkmegdlneMEIQLSQANRIASEAQKhLKNSQAHLKDTQL 1657
Cdd:pfam07888  146 L-ERETELERMKERAKKAGAQRK-----EEEAERKQLQAK---------LQQTEEELRSLSKEFQE-LRNSLAQRDTQVL 209
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1658 QLDDAVHAnddLKENIAIVERRNNLLQAELEELRAVveqtersrklaeQELIETSER-VQLLHSQNTSLINQKKKMESDL 1736
Cdd:pfam07888  210 QLQDTITT---LTQKLTTAHRKEAENEALLEELRSL------------QERLNASERkVEGLGEELSSMAAQRDRTQAEL 274
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1737 TQLQTEVEE----------AVQECRNAEEKAKKAITDAAMMAEElkKEQDTSAHLERMKKNMEQTIKDLQH------RLD 1800
Cdd:pfam07888  275 HQARLQAAQltlqladaslALREGRARWAQERETLQQSAEADKD--RIEKLSAELQRLEERLQEERMEREKlevelgREK 352
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|...
gi 6754774    1801 EAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELT 1853
Cdd:pfam07888  353 DCNRVQLSESRRELQELKASLRVAQKEKEQLQAEKQELLEYIRQLEQRLETVA 405
PRK01156 PRK01156
chromosome segregation protein; Provisional
920-1533 1.73e-05

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 49.90  E-value: 1.73e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    920 KVKEMTERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLT---K 996
Cdd:PRK01156  170 KLKDVIDMLRAEISNIDYLEEKLKSSNLELENIKKQIADDEKSHSITLKEIERLSIEYNNAMDDYNNLKSALNELSsleD 249
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    997 EKKALQEAHQQALDDLQAEEDKVNtltkskvkleqqvdDLEGSLEQEKKVRMDLERAKRklegdlkltqESIMDLENDKL 1076
Cdd:PRK01156  250 MKNRYESEIKTAESDLSMELEKNN--------------YYKELEERHMKIINDPVYKNR----------NYINDYFKYKN 305
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1077 QLEEKLKKKEfDISQQNSKIEDeqalalqLQKKLKENQArieeleeeleaERTARAKVEKLRSDLSRELEEISERLEEAG 1156
Cdd:PRK01156  306 DIENKKQILS-NIDAEINKYHA-------IIKKLSVLQK-----------DYNDYIKKKSRYDDLNNQILELEGYEMDYN 366
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1157 GATSVQIEMNKKREAEFQKMRR---DLEEATLQHEATAAALRKKHadsvAELGEQIDNLQRVKQKLEKEKSEFKLELDDV 1233
Cdd:PRK01156  367 SYLKSIESLKKKIEEYSKNIERmsaFISEILKIQEIDPDAIKKEL----NEINVKLQDISSKVSSLNQRIRALRENLDEL 442
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1234 TSNMEqIIKAKANLEKVSRTLEDQANEYRVKL--EEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYT 1311
Cdd:PRK01156  443 SRNME-MLNGQSVCPVCGTTLGEEKSNHIINHynEKKSRLEEKIREIEIEVKDIDEKIVDLKKRKEYLESEEINKSINEY 521
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1312 QQMEDLKRQLEEEGKAKNALAHALQSSRHDCDLLREQYEEEMEAKAElqrVLSKANSEvaqwRTKYETDAIQ-RTEELEE 1390
Cdd:PRK01156  522 NKIESARADLEDIKIKINELKDKHDKYEEIKNRYKSLKLEDLDSKRT---SWLNALAV----ISLIDIETNRsRSNEIKK 594
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1391 AKKKLAQRLQDAEEAVEAVNakcSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELE 1470
Cdd:PRK01156  595 QLNDLESRLQEIEIGFPDDK---SYIDKSIREIENEANNLNNKYNEIQENKILIEKLRGKIDNYKKQIAEIDSIIPDLKE 671
                         570       580       590       600       610       620
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6754774   1471 SSQKeARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKIRK 1533
Cdd:PRK01156  672 ITSR-INDIEDNLKKSRKALDDAKANRARLESTIEILRTRINELSDRINDINETLESMKKIKK 733
PRK01156 PRK01156
chromosome segregation protein; Provisional
1380-1925 2.01e-05

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 49.90  E-value: 2.01e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1380 DAIQRTEELEEAKKKLaqrlqdaEEAVEAVNAKCSSLEKTKHRLQNEIEDlmvdVERSNAAAAALDKKQRNFDKILAEWK 1459
Cdd:PRK01156  156 DEILEINSLERNYDKL-------KDVIDMLRAEISNIDYLEEKLKSSNLE----LENIKKQIADDEKSHSITLKEIERLS 224
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1460 QKYEESQSELESSQKEARSLSTeLFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGE--GGKNVHELEKIRKQLEV 1537
Cdd:PRK01156  225 IEYNNAMDDYNNLKSALNELSS-LEDMKNRYESEIKTAESDLSMELEKNNYYKELEERHMKiiNDPVYKNRNYINDYFKY 303
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1538 EK--LELQSALEEAEASLEHEEGKILRAQlEFNQIKAEIERKLAEKDE------EMEQAKRNHLRMVDSLQTSLDAETRS 1609
Cdd:PRK01156  304 KNdiENKKQILSNIDAEINKYHAIIKKLS-VLQKDYNDYIKKKSRYDDlnnqilELEGYEMDYNSYLKSIESLKKKIEEY 382
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1610 RNEALRVKKKMEGDLNEMEIQLSQANRIASEAQKHLKNSQAHLKDTQLQLDDAVHANDDLKENIAIVERRN--------- 1680
Cdd:PRK01156  383 SKNIERMSAFISEILKIQEIDPDAIKKELNEINVKLQDISSKVSSLNQRIRALRENLDELSRNMEMLNGQSvcpvcgttl 462
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1681 ---------NLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTS-LINQKKKMESDLTQLqTEVEEAVQEC 1750
Cdd:PRK01156  463 geeksnhiiNHYNEKKSRLEEKIREIEIEVKDIDEKIVDLKKRKEYLESEEINkSINEYNKIESARADL-EDIKIKINEL 541
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1751 RNAEEKAKKAITDAAMMAEELKKEQDTSaHLERMKKNMEQTIKDLQHRLDEAeqialkggKKQLQKLEARVRELENELEA 1830
Cdd:PRK01156  542 KDKHDKYEEIKNRYKSLKLEDLDSKRTS-WLNALAVISLIDIETNRSRSNEI--------KKQLNDLESRLQEIEIGFPD 612
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1831 EQKRNAESVKGMrKSERRIKELTYQTEEDKKNLMrlqdlvDKLQLKVKAYKRQA---EEAEEQANTNLSKFRKVQHELDE 1907
Cdd:PRK01156  613 DKSYIDKSIREI-ENEANNLNNKYNEIQENKILI------EKLRGKIDNYKKQIaeiDSIIPDLKEITSRINDIEDNLKK 685
                         570
                  ....*....|....*...
gi 6754774   1908 AEERADIAESQVNKLRAK 1925
Cdd:PRK01156  686 SRKALDDAKANRARLEST 703
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
1543-1932 2.22e-05

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 49.65  E-value: 2.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1543 QSALEEAEASLEHEEGKILRAQLefnqikAEIERKLAEKDEEMEQAKRNHLRMVDSLQTSLD--AETRSRNEALRVkkkM 1620
Cdd:PRK02224  186 RGSLDQLKAQIEEKEEKDLHERL------NGLESELAELDEEIERYEEQREQARETRDEADEvlEEHEERREELET---L 256
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1621 EGDLNEMEIQLSQANRIASEAQKHLKNSQAHLKDTQLQLDDAVHANDDLKENIAIVERRNNLLQAELEELRAVVEQTERS 1700
Cdd:PRK02224  257 EAEIEDLRETIAETEREREELAEEVRDLRERLEELEEERDDLLAEAGLDDADAEAVEARREELEDRDEELRDRLEECRVA 336
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1701 RKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQTEVE---EAVQECRNAEEKAKKAITDAAmmaEELKKEQDT 1777
Cdd:PRK02224  337 AQAHNEEAESLREDADDLEERAEELREEAAELESELEEAREAVEdrrEEIEELEEEIEELRERFGDAP---VDLGNAEDF 413
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1778 SAHLERMKKNMEQTIKDLqhrldEAEqialkggkkqLQKLEARVRELENELEA-------EQKRNAESVKGMRKSERRIK 1850
Cdd:PRK02224  414 LEELREERDELREREAEL-----EAT----------LRTARERVEEAEALLEAgkcpecgQPVEGSPHVETIEEDRERVE 478
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1851 ELTYQTEEDKKNLMRLQDLVDKLQlkvkaykrQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDIG 1930
Cdd:PRK02224  479 ELEAELEDLEEEVEEVEERLERAE--------DLVEAEDRIERLEERREDLEELIAERRETIEEKRERAEELRERAAELE 550

                  ..
gi 6754774   1931 AK 1932
Cdd:PRK02224  551 AE 552
CagA_N pfam18971
CagA protein; The Helicobacter pylori type IV secretion effector CagA is a major bacterial ...
842-1096 2.39e-05

CagA protein; The Helicobacter pylori type IV secretion effector CagA is a major bacterial virulence determinant and critical for gastric carcinogenesis. X-ray crystallographic analysis of the N-terminal CagA fragment (residues 1-876) revealed that the region has a structure comprised of three discrete domains. Domain I constitutes a mobile CagA N terminus, while Domain II tethers CagA to the plasma membrane by interacting with membrane phosphatidylserine. Domain III interacts intramolecularly with the intrinsically disordered C-terminal region, and this interaction potentiates the pathogenic scaffold/hub function of CagA.


Pssm-ID: 408741 [Multi-domain]  Cd Length: 876  Bit Score: 49.39  E-value: 2.39e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     842 LKSAETEKEMANMKEEFGRVKDALEKSEARR----KELEEKMVSLLQEKNDLQLQVQAeqdnlNDAEERCDQLIKNKIQL 917
Cdd:pfam18971  596 FNKAVAEAKSTGNYDEVKKAQKDLEKSLRKRehleKEVEKKLESKSGNKNKMEAKAQA-----NSQKDEIFALINKEANR 670
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     918 EAKVKEMTERLEDeeeMNAELTAKKRKLEDECSELKKDIDDLE----LTLAKVEKEKHATENKVKNLteemaGLD-EIIA 992
Cdd:pfam18971  671 DARAIAYTQNLKG---IKRELSDKLEKISKDLKDFSKSFDEFKngknKDFSKAEETLKALKGSVKDL-----GINpEWIS 742
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     993 KLTKEKKALQEAHQQALDDL----QAEEDKVNTLtkSKVKLEQQVDDLEGSLEQEKKVrmdlerakRKLEGDLKLTQESI 1068
Cdd:pfam18971  743 KVENLNAALNEFKNGKNKDFskvtQAKSDLENSV--KDVIINQKVTDKVDNLNQAVSV--------AKAMGDFSRVEQVL 812
                          250       260
                   ....*....|....*....|....*....
gi 6754774    1069 MDLEN-DKLQLEEKLKKKEFDISQQNSKI 1096
Cdd:pfam18971  813 ADLKNfSKEQLAQQAQKNEDFNTGKNSEL 841
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1746-1931 2.50e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 48.61  E-value: 2.50e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1746 AVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQiALKGGKKQLQKLEARVRELE 1825
Cdd:COG4942   18 QADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQ-ELAALEAELAELEKEIAELR 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1826 NELEAEQKRNAESVKGMRKSERR---------------IKELTY----------QTEEDKKNLMRLQDLVDKLQLKVKAY 1880
Cdd:COG4942   97 AELEAQKEELAELLRALYRLGRQpplalllspedfldaVRRLQYlkylaparreQAEELRADLAELAALRAELEAERAEL 176
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 6754774  1881 KRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDIGA 1931
Cdd:COG4942  177 EALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEA 227
Crescentin pfam19220
Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament ...
923-1338 2.53e-05

Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament proteins, named crescentin, whose cytoskeletal function is required for the vibrioid and helical shapes of Caulobacter crescentus. Without crescentin, the cells adopt a straight-rod morphology. Crescentin has characteriztic features of IF proteins including the ability to assemble into filaments in vitro without energy or cofactor requirements. In vivo, crescentin forms a helical structure that colocalizes with the inner cell curvatures beneath the cytoplasmic membrane.


Pssm-ID: 437057 [Multi-domain]  Cd Length: 401  Bit Score: 48.91  E-value: 2.53e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     923 EMTERLEDEEEMNAELTAKKRKLEDECSEL---KKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKK 999
Cdd:pfam19220   14 EMADRLEDLRSLKADFSQLIEPIEAILRELpqaKSRLLELEALLAQERAAYGKLRRELAGLTRRLSAAEGELEELVARLA 93
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1000 ALQEAHQQAldDLQAEEDKVNTLTKskvklEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLE 1079
Cdd:pfam19220   94 KLEAALREA--EAAKEELRIELRDK-----TAQAEALERQLAAETEQNRALEEENKALREEAQAAEKALQRAEGELATAR 166
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1080 EKLKKKEFDISQQNSKIEDEQALALQLQKKLKENQARieeleeeleaERTARAKVEKLRSDLSRELEEiSERLEEAggat 1159
Cdd:pfam19220  167 ERLALLEQENRRLQALSEEQAAELAELTRRLAELETQ----------LDATRARLRALEGQLAAEQAE-RERAEAQ---- 231
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1160 svqiemnkkreaefqkmrRDLEEATLQHEATAAALRKKHADSVAELGEQIdnLQRVKQKLeKEKSEfklELDDVTSNMEQ 1239
Cdd:pfam19220  232 ------------------LEEAVEAHRAERASLRMKLEALTARAAATEQL--LAEARNQL-RDRDE---AIRAAERRLKE 287
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1240 IIKAKANLEKVSRTLEDQANEYRVKLEEAQRslndfttQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKR 1319
Cdd:pfam19220  288 ASIERDTLERRLAGLEADLERRTQQFQEMQR-------ARAELEERAEMLTKALAAKDAALERAEERIASLSDRIAELTK 360
                          410
                   ....*....|....*....
gi 6754774    1320 QLEEEGKAKNALAHALQSS 1338
Cdd:pfam19220  361 RFEVERAALEQANRRLKEE 379
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1486-1937 2.58e-05

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 49.38  E-value: 2.58e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1486 LKNAYEESLEHLETFK-RENKNLQEEISDLTEQLGEGGKNVHELEKIRKQLEvEKLELQSALEEAEASLEHEEGKILRAQ 1564
Cdd:COG4717   47 LLERLEKEADELFKPQgRKPELNLKELKELEEELKEAEEKEEEYAELQEELE-ELEEELEELEAELEELREELEKLEKLL 125
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1565 --LEFNQIKAEIERKLAEKDEEMEQAKRNHlrmvdslqtsldaetRSRNEALRVKKKMEGDLNEMEIQLSQANRIASEAQ 1642
Cdd:COG4717  126 qlLPLYQELEALEAELAELPERLEELEERL---------------EELRELEEELEELEAELAELQEELEELLEQLSLAT 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1643 KHlknsqaHLKDTQLQLDDAVHANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQN 1722
Cdd:COG4717  191 EE------ELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERLKEARLLLLIAAALLALLGL 264
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1723 TSLINQKKKMESDLTQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKK--EQDTSAHLERMKKNMEQTIKDLQHRLD 1800
Cdd:COG4717  265 GGSLLSLILTIAGVLFLVLGLLALLFLLLAREKASLGKEAEELQALPALEEleEEELEELLAALGLPPDLSPEELLELLD 344
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1801 EAEQIalkggKKQLQKLEARVRELE-NELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNlmRLQDLVDKLQLKVKA 1879
Cdd:COG4717  345 RIEEL-----QELLREAEELEEELQlEELEQEIAALLAEAGVEDEEELRAALEQAEEYQELKE--ELEELEEQLEELLGE 417
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 6754774  1880 YKRQAEEAEEQANTnlSKFRKVQHELDEAEERADIAESQVNKLRAKSRDIGAKKMHDE 1937
Cdd:COG4717  418 LEELLEALDEEELE--EELEELEEELEELEEELEELREELAELEAELEQLEEDGELAE 473
Crescentin pfam19220
Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament ...
1475-1831 2.67e-05

Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament proteins, named crescentin, whose cytoskeletal function is required for the vibrioid and helical shapes of Caulobacter crescentus. Without crescentin, the cells adopt a straight-rod morphology. Crescentin has characteriztic features of IF proteins including the ability to assemble into filaments in vitro without energy or cofactor requirements. In vivo, crescentin forms a helical structure that colocalizes with the inner cell curvatures beneath the cytoplasmic membrane.


Pssm-ID: 437057 [Multi-domain]  Cd Length: 401  Bit Score: 48.91  E-value: 2.67e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1475 EARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKIRKQLEVEKLELQSALEEAEASLE 1554
Cdd:pfam19220   21 DLRSLKADFSQLIEPIEAILRELPQAKSRLLELEALLAQERAAYGKLRRELAGLTRRLSAAEGELEELVARLAKLEAALR 100
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1555 HEEGKILRAQLEFNQ---IKAEIERKLAEKDEEME------QAKRNHLRMVDSLQTSLDAETRSRNEALRV----KKKME 1621
Cdd:pfam19220  101 EAEAAKEELRIELRDktaQAEALERQLAAETEQNRaleeenKALREEAQAAEKALQRAEGELATARERLALleqeNRRLQ 180
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1622 GDLNEMEIQLSQANRIASEAQKHLKNSQAHLKDTQLQLddaVHANDDLKENIAIVERRNNLLQAE-------LEELRAVV 1694
Cdd:pfam19220  181 ALSEEQAAELAELTRRLAELETQLDATRARLRALEGQL---AAEQAERERAEAQLEEAVEAHRAEraslrmkLEALTARA 257
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1695 EQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQTEVEEAVQEcRNAEEKAKKAITD-AAMMAEELKk 1773
Cdd:pfam19220  258 AATEQLLAEARNQLRDRDEAIRAAERRLKEASIERDTLERRLAGLEADLERRTQQ-FQEMQRARAELEErAEMLTKALA- 335
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 6754774    1774 eqDTSAHLERMkknmEQTIKDLQHRLDEAEQIALKggkkQLQKLEARVRELENELEAE 1831
Cdd:pfam19220  336 --AKDAALERA----EERIASLSDRIAELTKRFEV----ERAALEQANRRLKEELQRE 383
COG5022 COG5022
Myosin heavy chain [General function prediction only];
1286-1625 2.86e-05

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 49.31  E-value: 2.86e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1286 NGELARQLEEKEALISQ--LTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQssrhdcdlLREQYEEEMEAKAE--LQR 1361
Cdd:COG5022  779 HGFRLRRLVDYELKWRLfiKLQPLLSLLGSRKEYRSYLACIIKLQKTIKREKK--------LRETEEVEFSLKAEvlIQK 850
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1362 VLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLaQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIE-DLMVDVERSNAA 1440
Cdd:COG5022  851 FGRSLKAKKRFSLLKKETIYLQSAQRVELAERQL-QELKIDVKSISSLKLVNLELESEIIELKKSLSsDLIENLEFKTEL 929
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1441 AAALDKKQRNFDKILAEWKQKYEESQSELESSQKeaRSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGE 1520
Cdd:COG5022  930 IARLKKLLNNIDLEEGPSIEYVKLPELNKLHEVE--SKLKETSEEYEDLLKKSTILVREGNKANSELKNFKKELAELSKQ 1007
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1521 GGKnVHELEKIRKQLEVEKLELQSAleEAEASLEHEEGKILR--AQLEFNQIKAeiERKLAEKDEEMEQAKRNHLRmvDS 1598
Cdd:COG5022 1008 YGA-LQESTKQLKELPVEVAELQSA--SKIISSESTELSILKplQKLKGLLLLE--NNQLQARYKALKLRRENSLL--DD 1080
                        330       340
                 ....*....|....*....|....*..
gi 6754774  1599 LQTSLDAETRSRNEALRVKKKMEGDLN 1625
Cdd:COG5022 1081 KQLYQLESTENLLKTINVKDLEVTNRN 1107
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
936-1160 2.97e-05

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 48.67  E-value: 2.97e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   936 AELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAE 1015
Cdd:COG3883   19 QAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGERARALYRS 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1016 EDKVNTLT-----KSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDIS 1090
Cdd:COG3883   99 GGSVSYLDvllgsESFSDFLDRLSALSKIADADADLLEELKADKAELEAKKAELEAKLAELEALKAELEAAKAELEAQQA 178
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1091 QQNSKIEDEQALALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATS 1160
Cdd:COG3883  179 EQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAASAAG 248
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
893-1115 3.32e-05

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 48.29  E-value: 3.32e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   893 VQAEqDNLNDAEERCDQLIKNKIQLEAKVKEMTERLEdeeemnaELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHA 972
Cdd:COG3883   12 AFAD-PQIQAKQKELSELQAELEAAQAELDALQAELE-------ELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEE 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   973 TENKVKNLTEEM----------------AGLDEIIAKLTKEKKaLQEAHQQALDDLQAEedkvntltksKVKLEQQVDDL 1036
Cdd:COG3883   84 RREELGERARALyrsggsvsyldvllgsESFSDFLDRLSALSK-IADADADLLEELKAD----------KAELEAKKAEL 152
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6754774  1037 EGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDISQQNSKIEDEQALALQLQKKLKENQA 1115
Cdd:COG3883  153 EAKLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAA 231
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1383-1613 3.51e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 48.22  E-value: 3.51e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1383 QRTEELEEAKKKLAQ---RLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWK 1459
Cdd:COG4942   24 EAEAELEQLQQEIAElekELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQK 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1460 QKYeesQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLgeggknvHELEKIRKQLEVEK 1539
Cdd:COG4942  104 EEL---AELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADL-------AELAALRAELEAER 173
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6754774  1540 LELQSALEEAEAslehEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRMVDSLQtSLDAETRSRNEA 1613
Cdd:COG4942  174 AELEALLAELEE----ERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIA-RLEAEAAAAAER 242
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
873-1225 3.64e-05

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 48.36  E-value: 3.64e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   873 KELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKIQLEAKVKEMTERLEDEEEMNAELTAKKRKLEDECSEL 952
Cdd:COG4372    6 EKVGKARLSLFGLRPKTGILIAALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEEL 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   953 KKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKSKVKLEQQ 1032
Cdd:COG4372   86 NEQLQAAQAELAQAQEELESLQEEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEE 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1033 VDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDISQQNSKIEDEQALALQLQKKLKE 1112
Cdd:COG4372  166 LAALEQELQALSEAEAEQALDELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELE 245
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1113 NQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAA 1192
Cdd:COG4372  246 EDKEELLEEVILKEIEELELAILVEKDTEEEELEIAALELEALEEAALELKLLALLLNLAALSLIGALEDALLAALLELA 325
                        330       340       350
                 ....*....|....*....|....*....|...
gi 6754774  1193 ALRKKHADSVAELGEQIDNLQRVKQKLEKEKSE 1225
Cdd:COG4372  326 KKLELALAILLAELADLLQLLLVGLLDNDVLEL 358
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
1630-1838 3.85e-05

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 48.29  E-value: 3.85e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1630 QLSQANRIASEAQKHLKNSQAHLKDTQLQLDDAVHANDDLKENIAIVERRNNLLQAELEELRA-VVEQTERSRKLAEQEL 1708
Cdd:COG3883   17 QIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAeIEERREELGERARALY 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1709 IE---TSERVQLLHSQNTS-LINQKKKMeSDLTQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEqdtsahLERM 1784
Cdd:COG3883   97 RSggsVSYLDVLLGSESFSdFLDRLSAL-SKIADADADLLEELKADKAELEAKKAELEAKLAELEALKAE------LEAA 169
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 6754774  1785 KKNMEQTIKDLQHRLDEAEQialkggkkQLQKLEARVRELENELEAEQKRNAES 1838
Cdd:COG3883  170 KAELEAQQAEQEALLAQLSA--------EEAAAEAQLAELEAELAAAEAAAAAA 215
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
1280-1649 3.95e-05

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 48.35  E-value: 3.95e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1280 AKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSSRHDCDLLREQYEEEMEAKAEL 1359
Cdd:pfam07888   34 NRLEECLQERAELLQAQEAANRQREKEKERYKRDREQWERQRRELESRVAELKEELRQSREKHEELEEKYKELSASSEEL 113
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1360 qrvlskanSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSna 1439
Cdd:pfam07888  114 --------SEEKDALLAQRAAHEARIRELEEDIKTLTQRVLERETELERMKERAKKAGAQRKEEEAERKQLQAKLQQT-- 183
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1440 aaaaldkkqrnfdkilaewkqkyeesqselessQKEARSLSTELFKLKNAYEESLEHLETfkrenknLQEEISDLTEQLG 1519
Cdd:pfam07888  184 ---------------------------------EEELRSLSKEFQELRNSLAQRDTQVLQ-------LQDTITTLTQKLT 223
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1520 EGGKNVHELEKIRKQL---------------------------------EVEKLELQSA---LEEAEASLEHEEGKILRA 1563
Cdd:pfam07888  224 TAHRKEAENEALLEELrslqerlnaserkveglgeelssmaaqrdrtqaELHQARLQAAqltLQLADASLALREGRARWA 303
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1564 QlefnqiKAEIERKLAEKDEE-MEQAKRNHLRMVDSLQtsldaETRSRNEALRVKKKMEGDLNemEIQLSQANRIASEAQ 1642
Cdd:pfam07888  304 Q------ERETLQQSAEADKDrIEKLSAELQRLEERLQ-----EERMEREKLEVELGREKDCN--RVQLSESRRELQELK 370

                   ....*..
gi 6754774    1643 KHLKNSQ 1649
Cdd:pfam07888  371 ASLRVAQ 377
Mitofilin pfam09731
Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. ...
847-1117 4.56e-05

Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. Mitofilin is enriched in the narrow space between the inner boundary and the outer membranes, where it forms a homotypic interaction and assembles into a large multimeric protein complex. The first 78 amino acids contain a typical amino-terminal-cleavable mitochondrial presequence rich in positive-charged and hydroxylated residues and a membrane anchor domain. In addition, it has three centrally located coiled coil domains.


Pssm-ID: 430783 [Multi-domain]  Cd Length: 618  Bit Score: 48.60  E-value: 4.56e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     847 TEKEMANMKEEFGRVKDALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDN--LNDAEERCDQLIKNKIQLEAKVKEm 924
Cdd:pfam09731  159 VKAHTDSLKEASDTAEISREKATDSALQKAEALAEKLKEVINLAKQSEEEAAPplLDAAPETPPKLPEHLDNVEEKVEK- 237
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     925 TERLEDEEEMNAELTAKKRklEDECSELKKDIDDLELTLAKVEKEKHATENKVknLTEEMAGLDEIIAKLTKEKKALQEA 1004
Cdd:pfam09731  238 AQSLAKLVDQYKELVASER--IVFQQELVSIFPDIIPVLKEDNLLSNDDLNSL--IAHAHREIDQLSKKLAELKKREEKH 313
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1005 HQQALDDLQAEEDKVNTLTKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESImdleNDKLQLEEKLKK 1084
Cdd:pfam09731  314 IERALEKQKEELDKLAEELSARLEEVRAADEAQLRLEFEREREEIRESYEEKLRTELERQAEAH----EEHLKDVLVEQE 389
                          250       260       270
                   ....*....|....*....|....*....|....*.
gi 6754774    1085 KEFDISQQ---NSKIEDEQALalqLQKKLKENQARI 1117
Cdd:pfam09731  390 IELQREFLqdiKEKVEEERAG---RLLKLNELLANL 422
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1434-1836 4.72e-05

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 48.23  E-value: 4.72e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1434 VERSNAAAAALDKKQRNFDKILAEwKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEhLETFKRENKNLQEEISD 1513
Cdd:COG4717   73 LKELEEELKEAEEKEEEYAELQEE-LEELEEELEELEAELEELREELEKLEKLLQLLPLYQE-LEALEAELAELPERLEE 150
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1514 LTEQLGEGGKNVHELEKIRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHL 1593
Cdd:COG4717  151 LEERLEELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELE 230
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1594 RMVDSLQTSLDAETRSRNEAL------------RVKKKMEGDLNEMEIQLSQANRIASEAQKHLKNSQAHLKDTQLQLDD 1661
Cdd:COG4717  231 QLENELEAAALEERLKEARLLlliaaallallgLGGSLLSLILTIAGVLFLVLGLLALLFLLLAREKASLGKEAEELQAL 310
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1662 AVHANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQ--ELIETSERVQLLHSQNTSLINQKKKMESDLTQL 1739
Cdd:COG4717  311 PALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLREaeELEEELQLEELEQEIAALLAEAGVEDEEELRAA 390
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1740 QTEVEEAVQ---ECRNAEEKAKKAITDAAMMAEELKKEQ--DTSAHLERMKKNMEQTIKDLQHRLDEAE-QIALKGGKKQ 1813
Cdd:COG4717  391 LEQAEEYQElkeELEELEEQLEELLGELEELLEALDEEEleEELEELEEELEELEEELEELREELAELEaELEQLEEDGE 470
                        410       420
                 ....*....|....*....|...
gi 6754774  1814 LQKLEARVRELENELEAEQKRNA 1836
Cdd:COG4717  471 LAELLQELEELKAELRELAEEWA 493
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1735-1933 5.29e-05

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 48.37  E-value: 5.29e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1735 DLTQLQTEVEEAvQECRNAEEKAKKAitdaammAEELKKEQDTSAHLERMKK-----NMEQTIKDLQHRLDEAEQiALKG 1809
Cdd:COG4913  236 DLERAHEALEDA-REQIELLEPIREL-------AERYAAARERLAELEYLRAalrlwFAQRRLELLEAELEELRA-ELAR 306
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1810 GKKQLQKLEARVRELENEL-EAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLMRLQDLVDKLQLKV----KAYKRQA 1884
Cdd:COG4913  307 LEAELERLEARLDALREELdELEAQIRGNGGDRLEQLEREIERLERELEERERRRARLEALLAALGLPLpasaEEFAALR 386
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 6754774  1885 EEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDIGAKK 1933
Cdd:COG4913  387 AEAAALLEALEEELEALEEALAEAEAALRDLRRELRELEAEIASLERRK 435
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
1191-1590 5.30e-05

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 48.41  E-value: 5.30e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1191 AAALRKKHADSVAELGEQIDNLQRVKQKL-EKEKSEFKLELDDVTSN--MEQIIKAKANLEKVSRTLEDQAnEYRVKLEE 1267
Cdd:COG3096  287 ALELRRELFGARRQLAEEQYRLVEMARELeELSARESDLEQDYQAASdhLNLVQTALRQQEKIERYQEDLE-ELTERLEE 365
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1268 AQRSLNDFTTQRAKLQTENgELARqlEEKEALISQLTrgklsytqqmeDLKRQLEEegkaknalahalQSSRhdcdllRE 1347
Cdd:COG3096  366 QEEVVEEAAEQLAEAEARL-EAAE--EEVDSLKSQLA-----------DYQQALDV------------QQTR------AI 413
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1348 QYEEEMEAKAELQRVLSKAN---SEVAQWRTKYETDAIQRTEELEEakkkLAQRLQDAEEAveavnakcssleKTKHRLQ 1424
Cdd:COG3096  414 QYQQAVQALEKARALCGLPDltpENAEDYLAAFRAKEQQATEEVLE----LEQKLSVADAA------------RRQFEKA 477
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1425 NEIEDLMVD-VERSNA--AAAALDKKQRNFdKILAE----WKQKYEESQSELESSqKEARSLSTELFKLKNAYEESLEHL 1497
Cdd:COG3096  478 YELVCKIAGeVERSQAwqTARELLRRYRSQ-QALAQrlqqLRAQLAELEQRLRQQ-QNAERLLEEFCQRIGQQLDAAEEL 555
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1498 ETFKREnknLQEEISDLTEQLGEGGKNVHELEKIRKQLEVEKLELQS------ALEEAEASLEHEEGKIL---RAQLEFN 1568
Cdd:COG3096  556 EELLAE---LEAQLEELEEQAAEAVEQRSELRQQLEQLRARIKELAArapawlAAQDALERLREQSGEALadsQEVTAAM 632
                        410       420
                 ....*....|....*....|..
gi 6754774  1569 QIKAEIERKLAEKDEEMEQAKR 1590
Cdd:COG3096  633 QQLLEREREATVERDELAARKQ 654
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
1141-1793 6.59e-05

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 47.89  E-value: 6.59e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1141 LSRELEEISERLEEaggaTSVQIEMNKKR-EAEFQKMRRDLEeaTLQHEATAAALRKKHADSVAELGE---QIDNLQRVK 1216
Cdd:pfam10174  128 QAKELFLLRKTLEE----MELRIETQKQTlGARDESIKKLLE--MLQSKGLPKKSGEEDWERTRRIAEaemQLGHLEVLL 201
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1217 QKLEKEKSEFKLEL---------DDVTSNMEQIIKAK----ANLEKVSRTLEDQAN-------------EYRVKLEEAQR 1270
Cdd:pfam10174  202 DQKEKENIHLREELhrrnqlqpdPAKTKALQTVIEMKdtkiSSLERNIRDLEDEVQmlktngllhtedrEEEIKQMEVYK 281
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1271 SLNDFttqrakLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLE---EEGKAKNALAHALQSsrhDCDLLRE 1347
Cdd:pfam10174  282 SHSKF------MKNKIDQLKQELSKKESELLALQTKLETLTNQNSDCKQHIEvlkESLTAKEQRAAILQT---EVDALRL 352
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1348 QYEEEmeakaelQRVLSKansevaqwrtkyETDAIQRteeLEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEI 1427
Cdd:pfam10174  353 RLEEK-------ESFLNK------------KTKQLQD---LTEEKSTLAGEIRDLKDMLDVKERKINVLQKKIENLQEQL 410
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1428 EDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKyEESQSELESSQKEARSLSTElfklknayeESLEHLETFKRENKNL 1507
Cdd:pfam10174  411 RDKDKQLAGLKERVKSLQTDSSNTDTALTTLEEA-LSEKERIIERLKEQREREDR---------ERLEELESLKKENKDL 480
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1508 QEEISDLTEQLGEGGKNVHELEKIRKQLEVEKLELQSALEEAEASLEH--EEGKILRAQLEFNQIKAEIERK---LAEKD 1582
Cdd:pfam10174  481 KEKVSALQPELTEKESSLIDLKEHASSLASSGLKKDSKLKSLEIAVEQkkEECSKLENQLKKAHNAEEAVRTnpeINDRI 560
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1583 EEMEQAKRNHLRMVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSQANRIASEAQKHLKNSQAHLKDTQLQLDDA 1662
Cdd:pfam10174  561 RLLEQEVARYKEESGKAQAEVERLLGILREVENEKNDKDKKIAELESLTLRQMKEQNKKVANIKHGQQEMKKKGAQLLEE 640
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1663 VHANDDlkeniaivERRNNLLQAELEELRAVVEQTersrklaEQELIETSERV----QLLHSQNTSLIN----QKKKMEs 1734
Cdd:pfam10174  641 ARRRED--------NLADNSQQLQLEELMGALEKT-------RQELDATKARLsstqQSLAEKDGHLTNlraeRRKQLE- 704
                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1735 dltqlqtEVEEAVQECRNAEEKAKKA-ITDAAMMAEELKKEQDTSAHLERMKKNMEQTIK 1793
Cdd:pfam10174  705 -------EILEMKQEALLAAISEKDAnIALLELSSSKKKKTQEEVMALKREKDRLVHQLK 757
HOOK pfam05622
HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from ...
1399-1830 7.38e-05

HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from different eukaryotic organizms. The different members of the human gene family are HOOK1, HOOK2 and HOOK3. Different domains have been identified in the three human HOOK proteins, and it was demonstrated that the highly conserved NH2-domain mediates attachment to microtubules, whereas this central coiled-coil motif mediates homodimerization and the more divergent C-terminal domains are involved in binding to specific organelles (organelle-binding domains). It has been demonstrated that endogenous HOOK3 binds to Golgi membranes, whereas both HOOK1 and HOOK2 are localized to discrete but unidentified cellular structures. In mice the Hook1 gene is predominantly expressed in the testis. Hook1 function is necessary for the correct positioning of microtubular structures within the haploid germ cell. Disruption of Hook1 function in mice causes abnormal sperm head shape and fragile attachment of the flagellum to the sperm head. This entry includes the central coiled-coiled domain and the divergent C-terminal domain.


Pssm-ID: 461694 [Multi-domain]  Cd Length: 528  Bit Score: 47.76  E-value: 7.38e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1399 LQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDkkqrNFDKILAEWKQKYEESQselessqKEARS 1478
Cdd:pfam05622    2 LSEAQEEKDELAQRCHELDQQVSLLQEEKNSLQQENKKLQERLDQLE----SGDDSGTPGGKKYLLLQ-------KQLEQ 70
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1479 LSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLT-------------------------------------EQLGEG 1521
Cdd:pfam05622   71 LQEENFRLETARDDYRIKCEELEKEVLELQHRNEELTslaeeaqalkdemdilressdkvkkleatvetykkklEDLGDL 150
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1522 GKNVHELEK---------------------IRKQLEVEKLELQsaleEAEASLEHEEGKILRAQLEFNQIKA-------E 1573
Cdd:pfam05622  151 RRQVKLLEErnaeymqrtlqleeelkkanaLRGQLETYKRQVQ----ELHGKLSEESKKADKLEFEYKKLEEklealqkE 226
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1574 IERKLAEKD---EEMEQAKRNHLRMVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSQANRIASEAQKhlKNSQA 1650
Cdd:pfam05622  227 KERLIIERDtlrETNEELRCAQLQQAELSQADALLSPSSDPGDNLAAEIMPAEIREKLIRLQHENKMLRLGQE--GSYRE 304
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1651 HLKDTQLQLDDAVHANDDLKENIAIVERRNNLLQAELEELRavveqtersRKLAEQElietservqllhSQNTSLINQKK 1730
Cdd:pfam05622  305 RLTELQQLLEDANRRKNELETQNRLANQRILELQQQVEELQ---------KALQEQG------------SKAEDSSLLKQ 363
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1731 KMESDLTQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEEL-----KKEQDTSAHLERMKKNMEQ---TIKDLQHRLDEA 1802
Cdd:pfam05622  364 KLEEHLEKLHEAQSELQKKKEQIEELEPKQDSNLAQKIDELqealrKKDEDMKAMEERYKKYVEKaksVIKTLDPKQNPA 443
                          490       500
                   ....*....|....*....|....*...
gi 6754774    1803 EQIALKGGKKQLQKLEARVRELENELEA 1830
Cdd:pfam05622  444 SPPEIQALKNQLLEKDKKIEHLERDFEK 471
MutS2 COG1193
dsDNA-specific endonuclease/ATPase MutS2 [Replication, recombination and repair];
1050-1204 7.86e-05

dsDNA-specific endonuclease/ATPase MutS2 [Replication, recombination and repair];


Pssm-ID: 440806 [Multi-domain]  Cd Length: 784  Bit Score: 47.83  E-value: 7.86e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1050 LERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKkefdISQQNSKIEDEQALALQLQKKLKENQARIEELeeeleaert 1129
Cdd:COG1193  502 IERARELLGEESIDVEKLIEELERERRELEEEREE----AERLREELEKLREELEEKLEELEEEKEEILEK--------- 568
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6754774  1130 ARAKVEKLRSDLSRELEEISERLEEAggatsvqiemnKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAE 1204
Cdd:COG1193  569 AREEAEEILREARKEAEELIRELREA-----------QAEEEELKEARKKLEELKQELEEKLEKPKKKAKPAKPP 632
PRK10246 PRK10246
exonuclease subunit SbcC; Provisional
1238-1886 9.37e-05

exonuclease subunit SbcC; Provisional


Pssm-ID: 182330 [Multi-domain]  Cd Length: 1047  Bit Score: 47.49  E-value: 9.37e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1238 EQIIKAKANLEKvsrtLEDQANEYRVKLEEAQRSLNdfTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDL 1317
Cdd:PRK10246  191 EQHKSARTELEK----LQAQASGVALLTPEQVQSLT--ASLQVLTDEEKQLLTAQQQQQQSLNWLTRLDELQQEASRRQQ 264
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1318 KRQLEEEGKAKNALAHALQSSRHDCDLLREQYEEEMEAKAELQRVLSKANS------EVAQWRTKYETDAIQRTEELEEA 1391
Cdd:PRK10246  265 ALQQALAAEEKAQPQLAALSLAQPARQLRPHWERIQEQSAALAHTRQQIEEvntrlqSTMALRARIRHHAAKQSAELQAQ 344
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1392 KKKLAQRLQDAE------EAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNA------------AAAALDK--KQRNF 1451
Cdd:PRK10246  345 QQSLNTWLAEHDrfrqwnNELAGWRAQFSQQTSDREQLRQWQQQLTHAEQKLNAlpaitltltadeVAAALAQhaEQRPL 424
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1452 DKILAEWKQKYEESQSELESSQKEARSLSTELFKLKnayeeslEHLETFKRENKNLQEEISDLteqlgeggKNVHELEKI 1531
Cdd:PRK10246  425 RQRLVALHGQIVPQQKRLAQLQVAIQNVTQEQTQRN-------AALNEMRQRYKEKTQQLADV--------KTICEQEAR 489
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1532 RKQLEVEKLELQS-------------------------------ALEEAEASLEhEEGKILRAQLE--FNQIK------- 1571
Cdd:PRK10246  490 IKDLEAQRAQLQAgqpcplcgstshpaveayqalepgvnqsrldALEKEVKKLG-EEGAALRGQLDalTKQLQrdeseaq 568
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1572 --AEIERKLAEKDEEMEQAKRNHLRMVDSLQTSLDAETRSRNE--ALRVKKKMEGDLNEMEIQLSQANRIASEAQKHLKN 1647
Cdd:PRK10246  569 slRQEEQALTQQWQAVCASLNITLQPQDDIQPWLDAQEEHERQlrLLSQRHELQGQIAAHNQQIIQYQQQIEQRQQQLLT 648
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1648 SQAHLKDTQLQLDDA---VHANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTS 1724
Cdd:PRK10246  649 ALAGYALTLPQEDEEaswLATRQQEAQSWQQRQNELTALQNRIQQLTPLLETLPQSDDLPHSEETVALDNWRQVHEQCLS 728
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1725 LINQKKKMESDLTQLQTEVEEAVQECRNAEEK---AKKAITDAAMMAEElkkeqdTSAHLERMKKNMEQTIKDLQHRLDE 1801
Cdd:PRK10246  729 LHSQLQTLQQQDVLEAQRLQKAQAQFDTALQAsvfDDQQAFLAALLDEE------TLTQLEQLKQNLENQRQQAQTLVTQ 802
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1802 AEQialkggkKQLQKLEARVRELENELEAE--QKRNAESVKGMRKSERRIKELTYQTEEDKKNLMRLQDLVdklqLKVKA 1879
Cdd:PRK10246  803 TAQ-------ALAQHQQHRPDGLDLTVTVEqiQQELAQLAQQLRENTTRQGEIRQQLKQDADNRQQQQALM----QQIAQ 871

                  ....*..
gi 6754774   1880 YKRQAEE 1886
Cdd:PRK10246  872 ATQQVED 878
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
1088-1302 1.05e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 46.75  E-value: 1.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1088 DISQQNSKIEDEQALALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEaggatsvqiemnk 1167
Cdd:COG3883   17 QIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEE------------- 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1168 kREAEFQKMRRDLEEATLQHEATAAALrkkHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANL 1247
Cdd:COG3883   84 -RREELGERARALYRSGGSVSYLDVLL---GSESFSDFLDRLSALSKIADADADLLEELKADKAELEAKKAELEAKLAEL 159
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 6754774  1248 EKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQ 1302
Cdd:COG3883  160 EALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAA 214
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
845-1251 1.12e-04

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 46.81  E-value: 1.12e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     845 AETEKEMANMKEEFGRVKDALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKIQLEAKVKEM 924
Cdd:pfam07888   76 RELESRVAELKEELRQSREKHEELEEKYKELSASSEELSEEKDALLAQRAAHEARIRELEEDIKTLTQRVLERETELERM 155
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     925 TERLEdeeemnaELTAKKRKLEDECSelkkdidDLELTLAKVEKEKHatenkvknlteemagldeiiaKLTKEKKALQEA 1004
Cdd:pfam07888  156 KERAK-------KAGAQRKEEEAERK-------QLQAKLQQTEEELR---------------------SLSKEFQELRNS 200
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1005 HQQALDDLQAEEDKVNTLTKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGdlkLTQE-SIMDLENDKLQLEekLK 1083
Cdd:pfam07888  201 LAQRDTQVLQLQDTITTLTQKLTTAHRKEAENEALLEELRSLQERLNASERKVEG---LGEElSSMAAQRDRTQAE--LH 275
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1084 KKEFDISQQNSKIEDeqaLALQLqkklkenqarieeleeeleaeRTARAKVEKLRSDLSRELEEISERLEeaggatsvqi 1163
Cdd:pfam07888  276 QARLQAAQLTLQLAD---ASLAL---------------------REGRARWAQERETLQQSAEADKDRIE---------- 321
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1164 emnkKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKL---EKEKSEFKLELDDVtsnMEQI 1240
Cdd:pfam07888  322 ----KLSAELQRLEERLQEERMEREKLEVELGREKDCNRVQLSESRRELQELKASLrvaQKEKEQLQAEKQEL---LEYI 394
                          410
                   ....*....|.
gi 6754774    1241 IKAKANLEKVS 1251
Cdd:pfam07888  395 RQLEQRLETVA 405
46 PHA02562
endonuclease subunit; Provisional
1689-1873 1.15e-04

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 46.93  E-value: 1.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1689 ELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQTEVEEAVQECRNAEEKAKK---AITDAA 1765
Cdd:PHA02562  189 KIDHIQQQIKTYNKNIEEQRKKNGENIARKQNKYDELVEEAKTIKAEIEELTDELLNLVMDIEDPSAALNKlntAAAKIK 268
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1766 MMAEELKKE--------------QDTSAHLERMKKNMEQtIKDLQHRLDEAE--QIALKGGKKQLQKLEARVRELENELE 1829
Cdd:PHA02562  269 SKIEQFQKVikmyekggvcptctQQISEGPDRITKIKDK-LKELQHSLEKLDtaIDELEEIMDEFNEQSKKLLELKNKIS 347
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 6754774   1830 AEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLMRLQDLVDKL 1873
Cdd:PHA02562  348 TNKQSLITLVDKAKKVKAAIEELQAEFVDNAEELAKLQDELDKI 391
PLN02939 PLN02939
transferase, transferring glycosyl groups
1599-1934 1.20e-04

transferase, transferring glycosyl groups


Pssm-ID: 215507 [Multi-domain]  Cd Length: 977  Bit Score: 47.20  E-value: 1.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1599 LQTSLDAETRSRNEALR----VKKKMEGDLNEMEIQLSQANR-IASEAQKHLKNSQAHLKDTQLQLDDAVHANDDLKENI 1673
Cdd:PLN02939   65 LQSNTDENGQLENTSLRtvmeLPQKSTSSDDDHNRASMQRDEaIAAIDNEQQTNSKDGEQLSDFQLEDLVGMIQNAEKNI 144
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1674 AIVER--------------RNNLLQAELEELRAVVEQTERSRKLAEQELIetseRVQLLHSQntsLINQKKKMESDLTQL 1739
Cdd:PLN02939  145 LLLNQarlqaledlekiltEKEALQGKINILEMRLSETDARIKLAAQEKI----HVEILEEQ---LEKLRNELLIRGATE 217
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1740 QTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTS---AHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQK 1816
Cdd:PLN02939  218 GLCVHSLSKELDVLKEENMLLKDDIQFLKAELIEVAETEervFKLEKERSLLDASLRELESKFIVAQEDVSKLSPLQYDC 297
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1817 LEARVRELENELEAEQKRNAESV---KGMRKSERRIKELTYQTEEDKKNLMRLQdLVDKLQLKVKAYKRQAEEAEEQANT 1893
Cdd:PLN02939  298 WWEKVENLQDLLDRATNQVEKAAlvlDQNQDLRDKVDKLEASLKEANVSKFSSY-KVELLQQKLKLLEERLQASDHEIHS 376
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 6754774   1894 nlskfrKVQHELDEAEERADIAESQVNKLRAKSRDIGAKKM 1934
Cdd:PLN02939  377 ------YIQLYQESIKEFQDTLSKLKEESKKRSLEHPADDM 411
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
1058-1292 1.21e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 46.75  E-value: 1.21e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1058 EGDLKLTQESIMDLENDKLQLEEKLKKKEFDISQQNSKIEDEQALALQLQKKLKENQARIEEleeeleaertARAKVEKL 1137
Cdd:COG3883   15 DPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAE----------AEAEIEER 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1138 RSDLSRELEEISERLEEAG------GATSV-----QIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKhadsVAELG 1206
Cdd:COG3883   85 REELGERARALYRSGGSVSyldvllGSESFsdfldRLSALSKIADADADLLEELKADKAELEAKKAELEAK----LAELE 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1207 EQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTEN 1286
Cdd:COG3883  161 ALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA 240

                 ....*.
gi 6754774  1287 GELARQ 1292
Cdd:COG3883  241 AAAASA 246
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
845-1016 1.22e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 46.75  E-value: 1.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   845 AETEKEMANMKEEfgrVKDALEKSEARRKELEEKMVSLLQEKNDLQ-LQVQAEQDNLNDAEERCDQLikNKIqleakVKE 923
Cdd:COG3883   61 EALQAEIDKLQAE---IAEAEAEIEERREELGERARALYRSGGSVSyLDVLLGSESFSDFLDRLSAL--SKI-----ADA 130
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   924 MTERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQE 1003
Cdd:COG3883  131 DADLLEELKADKAELEAKKAELEAKLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEA 210
                        170
                 ....*....|...
gi 6754774  1004 AHQQALDDLQAEE 1016
Cdd:COG3883  211 AAAAAAAAAAAAA 223
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1571-1809 1.35e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 46.30  E-value: 1.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1571 KAEIERKLAEKDEEMEQAKRNHlrmvDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSQANRIASEAQKHLKNSQA 1650
Cdd:COG4942   29 LEQLQQEIAELEKELAALKKEE----KALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQKE 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1651 HLKDtQLQLDDAVHANDDLK-----ENIAIVERRNNLLQAELEELRAVVEQTERSRklaeqelietservQLLHSQNTSL 1725
Cdd:COG4942  105 ELAE-LLRALYRLGRQPPLAlllspEDFLDAVRRLQYLKYLAPARREQAEELRADL--------------AELAALRAEL 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1726 INQKKKMESDLTQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQI 1805
Cdd:COG4942  170 EAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPAAGFA 249

                 ....
gi 6754774  1806 ALKG 1809
Cdd:COG4942  250 ALKG 253
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
1573-1902 1.35e-04

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 47.27  E-value: 1.35e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1573 EIERKLAEKDEEMEQAKRNHLRMVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLsqANRIASEAQKHLKNSQAHL 1652
Cdd:pfam02463  169 RKKKEALKKLIEETENLAELIIDLEELKLQELKLKEQAKKALEYYQLKEKLELEEEYLL--YLDYLKLNEERIDLLQELL 246
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1653 KDTQLQLDDAVHANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKM 1732
Cdd:pfam02463  247 RDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKEKKKA 326
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1733 ESDLTQLQT-----EVEEAVQECRNAEEKAKKaitdAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIAL 1807
Cdd:pfam02463  327 EKELKKEKEeieelEKELKELEIKREAEEEEE----EELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELELKSE 402
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1808 KGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLMRLQDLVDKLQLKVKAYKRQAEEA 1887
Cdd:pfam02463  403 EEKEAQLLLELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLLKDELELKKSEDLLKETQLVKL 482
                          330
                   ....*....|....*
gi 6754774    1888 EEQANTNLSKFRKVQ 1902
Cdd:pfam02463  483 QEQLELLLSRQKLEE 497
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
1342-1554 1.37e-04

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 46.84  E-value: 1.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1342 CDLLREQYEEEMEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKH 1421
Cdd:PRK05771   38 EELSNERLRKLRSLLTKLSEALDKLRSYLPKLNPLREEKKKVSVKSLEELIKDVEEELEKIEKEIKELEEEISELENEIK 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1422 RLQNEIEDLM------VDVER----SNAAAAALDKKQRNFDKILAEWKQKYEESQSELESS-------QKEARSLSTELF 1484
Cdd:PRK05771  118 ELEQEIERLEpwgnfdLDLSLllgfKYVSVFVGTVPEDKLEELKLESDVENVEYISTDKGYvyvvvvvLKELSDEVEEEL 197
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6754774   1485 KlKNAYEE-SLEHLETFKRENKNLQEEISDLTEQLGEggkNVHELEKIRKQLEVEKL----ELQSALEEAEASLE 1554
Cdd:PRK05771  198 K-KLGFERlELEEEGTPSELIREIKEELEEIEKERES---LLEELKELAKKYLEELLalyeYLEIELERAEALSK 268
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
891-1061 1.38e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 45.30  E-value: 1.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   891 LQVQAEQDNLNDAEERCDQLIKNKIQLEAKVKEMTERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEK 970
Cdd:COG1579   10 LDLQELDSELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLGNVRNNK 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   971 HatenkVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKSKVKLEQQVDDLEGSLEQE-KKVRMD 1049
Cdd:COG1579   90 E-----YEALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAElEELEAE 164
                        170
                 ....*....|..
gi 6754774  1050 LERAKRKLEGDL 1061
Cdd:COG1579  165 REELAAKIPPEL 176
HEC1 COG5185
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
972-1329 1.42e-04

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 46.87  E-value: 1.42e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   972 ATENKVKNLTEEMAGLDEIIaKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKSKVKLEQQVDDLEGSLEQEKKVRM-DL 1050
Cdd:COG5185  202 GTVNSIKESETGNLGSESTL-LEKAKEIINIEEALKGFQDPESELEDLAQTSDKLEKLVEQNTDLRLEKLGENAESSkRL 280
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1051 ERAKRKLEGDLKLTQESIMDLE------------NDKLQLEEKLKKKEFDISQQNSKIEDEQALALQLQKKLKENQARIE 1118
Cdd:COG5185  281 NENANNLIKQFENTKEKIAEYTksidikkateslEEQLAAAEAEQELEESKRETETGIQNLTAEIEQGQESLTENLEAIK 360
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1119 ELEEELEAERTARAKVEKLRSdLSRELEEISERLEEAGGATSVQIEMNKKREA--------EFQKMRRDLEEATLQHEAT 1190
Cdd:COG5185  361 EEIENIVGEVELSKSSEELDS-FKDTIESTKESLDEIPQNQRGYAQEILATLEdtlkaadrQIEELQRQIEQATSSNEEV 439
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1191 AAALRKKHADSVAELGEQIDNLQ-RVKQKLEKEKSEFKLELDDVTSNMEQIIKA----KANLEKVSRTLEDQANEYRVKL 1265
Cdd:COG5185  440 SKLLNELISELNKVMREADEESQsRLEEAYDEINRSVRSKKEDLNEELTQIESRvstlKATLEKLRAKLERQLEGVRSKL 519
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6754774  1266 EEAQRSLNDFTTQRAKLQTENGELARQLEEK---------EALISQLTRGKLSYTQQMEDLKRQLEEEGKAKN 1329
Cdd:COG5185  520 DQVAESLKDFMRARGYAHILALENLIPASELiqasnaktdGQAANLRTAVIDELTQYLSTIESQQAREDPIPD 592
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
1486-1932 1.46e-04

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 47.02  E-value: 1.46e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1486 LKNAYEESLEHLETFKRENKNLQEEISDLTEQLGeggKNVHELEKIRKQLEVEKLELQSALEEAEASLEHEEgkilraql 1565
Cdd:pfam05483  160 LKETCARSAEKTKKYEYEREETRQVYMDLNNNIE---KMILAFEELRVQAENARLEMHFKLKEDHEKIQHLE-------- 228
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1566 efNQIKAEIERKLAEKDEEMEQAKRNHLRMVDslQTSLDAETRSRNEALRVKKKMEGDlnemeiQLSQANriasEAQKHL 1645
Cdd:pfam05483  229 --EEYKKEINDKEKQVSLLLIQITEKENKMKD--LTFLLEESRDKANQLEEKTKLQDE------NLKELI----EKKDHL 294
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1646 KnsqAHLKDTQLQLDDAVHANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQ-LLHSQNTS 1724
Cdd:pfam05483  295 T---KELEDIKMSLQRSMSTQKALEEDLQIATKTICQLTEEKEAQMEELNKAKAAHSFVVTEFEATTCSLEeLLRTEQQR 371
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1725 LIN---QKKKMESDLTQLQTEVEEAVQECRNAE---EKAKKAITDAAMMAEELKKEQDTSahlERMKKNMEQTIKDLQHR 1798
Cdd:pfam05483  372 LEKnedQLKIITMELQKKSSELEEMTKFKNNKEvelEELKKILAEDEKLLDEKKQFEKIA---EELKGKEQELIFLLQAR 448
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1799 LDEAE--QIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLMRLQDLVDKLQLK 1876
Cdd:pfam05483  449 EKEIHdlEIQLTAIKTSEEHYLKEVEDLKTELEKEKLKNIELTAHCDKLLLENKELTQEASDMTLELKKHQEDIINCKKQ 528
                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6754774    1877 VKAYKRQAE---EAEEQANTNLSKFRK--------VQHELDEAEERADIAESQVNKLRAKSRDIGAK 1932
Cdd:pfam05483  529 EERMLKQIEnleEKEMNLRDELESVREefiqkgdeVKCKLDKSEENARSIEYEVLKKEKQMKILENK 595
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
844-1794 1.60e-04

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 46.97  E-value: 1.60e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     844 SAETEKEMANMKEEFGRVKDALEkseaRRKELEEKMVSLLQEKNDlqlQVQAEQDNLNDAEERCDQLIKNKIqlEAKVKE 923
Cdd:TIGR01612  478 SYDIKKDIDENSKQDNTVKLILM----RMKDFKDIIDFMELYKPD---EVPSKNIIGFDIDQNIKAKLYKEI--EAGLKE 548
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     924 MTERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKE-------KHATENKVKNLTEEmaglDEIIAKLTK 996
Cdd:TIGR01612  549 SYELAKNWKKLIHEIKKELEEENEDSIHLEKEIKDLFDKYLEIDDEiiyinklKLELKEKIKNISDK----NEYIKKAID 624
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     997 EKKALqEAHQQALDDL-QAEEDKVNTLTKSKVKLEQQVDDlegslEQEKKVRMDLERAKRKLEgdlKLTQESIMDLENDK 1075
Cdd:TIGR01612  625 LKKII-ENNNAYIDELaKISPYQVPEHLKNKDKIYSTIKS-----ELSKIYEDDIDALYNELS---SIVKENAIDNTEDK 695
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1076 LQLEEkLKKKefdISQQNSKIEDEQALALQLQKKLKENQarieeleeELEAERTARAKVEKLRSDLSRELEEISERLEEA 1155
Cdd:TIGR01612  696 AKLDD-LKSK---IDKEYDKIQNMETATVELHLSNIENK--------KNELLDIIVEIKKHIHGEINKDLNKILEDFKNK 763
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1156 GGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADS---VAELGEQIDNLQRVKQKLEKEKSEFKLELDD 1232
Cdd:TIGR01612  764 EKELSNKINDYAKEKDELNKYKSKISEIKNHYNDQINIDNIKDEDAkqnYDKSKEYIKTISIKEDEIFKIINEMKFMKDD 843
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1233 VTSNMEQIIKAKANLEKVSRTLEDQANEY--RVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKlSY 1310
Cdd:TIGR01612  844 FLNKVDKFINFENNCKEKIDSEHEQFAELtnKIKAEISDDKLNDYEKKFNDSKSLINEINKSIEEEYQNINTLKKVD-EY 922
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1311 TQQMEDLKRQLEEEGKAKNALAHALQSSR---HDCDLLREQYEEEME-----AKAELQRVLSKA--------NSEVAQW- 1373
Cdd:TIGR01612  923 IKICENTKESIEKFHNKQNILKEILNKNIdtiKESNLIEKSYKDKFDntlidKINELDKAFKDAslndyeakNNELIKYf 1002
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1374 -------RTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVN-AKCSSLEKTKHRLQNEI----EDLMVDV-ERSNAA 1440
Cdd:TIGR01612 1003 ndlkanlGKNKENMLYHQFDEKEKATNDIEQKIEDANKNIPNIEiAIHTSIYNIIDEIEKEIgkniELLNKEIlEEAEIN 1082
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1441 AAALDK-----KQRNFDKILAEWKQKYEesqselessqKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISdlt 1515
Cdd:TIGR01612 1083 ITNFNEikeklKHYNFDDFGKEENIKYA----------DEINKIKDDIKNLDQKIDHHIKALEEIKKKSENYIDEIK--- 1149
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1516 eqlgeggKNVHELEKIrkqleVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEI-ERKLAEKDE-EMEQAKRNHL 1593
Cdd:TIGR01612 1150 -------AQINDLEDV-----ADKAISNDDPEEIEKKIENIVTKIDKKKNIYDEIKKLLnEIAEIEKDKtSLEEVKGINL 1217
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1594 RMVDSLQT----SLDAEtrsrnealrvKKKMEGDLNEMEIQLSQANRIASEAQKhLKNSQAHLKDTQLQLDDAVHANDDL 1669
Cdd:TIGR01612 1218 SYGKNLGKlfleKIDEE----------KKKSEHMIKAMEAYIEDLDEIKEKSPE-IENEMGIEMDIKAEMETFNISHDDD 1286
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1670 KENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEqelIETSERVQLLHSQ-NTSLINQKKKMESDLTQLQT-----EV 1743
Cdd:TIGR01612 1287 KDHHIISKKHDENISDIREKSLKIIEDFSEESDIND---IKKELQKNLLDAQkHNSDINLYLNEIANIYNILKlnkikKI 1363
                          970       980       990      1000      1010
                   ....*....|....*....|....*....|....*....|....*....|.
gi 6754774    1744 EEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKD 1794
Cdd:TIGR01612 1364 IDEVKEYTKEIEENNKNIKDELDKSEKLIKKIKDDINLEECKSKIESTLDD 1414
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
994-1251 1.76e-04

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 46.55  E-value: 1.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   994 LTKEKKALQEAhQQALDDLQAEEDKVNTLTKSKVkLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLEN 1073
Cdd:COG3206  184 LPELRKELEEA-EAALEEFRQKNGLVDLSEEAKL-LLQQLSELESQLAEARAELAEAEARLAALRAQLGSGPDALPELLQ 261
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1074 DklQLEEKLKKKEFDISQQnskiedeqaLAlQLQKKLKENQARIeeleeeleaeRTARAKVEKLRSDLSRELEEISERLE 1153
Cdd:COG3206  262 S--PVIQQLRAQLAELEAE---------LA-ELSARYTPNHPDV----------IALRAQIAALRAQLQQEAQRILASLE 319
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1154 eaggatsVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRkkhadsvaELGEQIDNLQRVKQKLEKEKSEFKLELDDV 1233
Cdd:COG3206  320 -------AELEALQAREASLQAQLAQLEARLAELPELEAELR--------RLEREVEVARELYESLLQRLEEARLAEALT 384
                        250
                 ....*....|....*...
gi 6754774  1234 TSNMEQIIKAKANLEKVS 1251
Cdd:COG3206  385 VGNVRVIDPAVVPLKPVS 402
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
1675-1921 1.98e-04

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 46.36  E-value: 1.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1675 IVERRNNLLQAELEELRAVVEQTERSRKLAEQELIEtserVQLLHSQNTSLinqKKKMESDLTQLQTEVEEAVQEcrnAE 1754
Cdd:PRK00409  503 IIEEAKKLIGEDKEKLNELIASLEELERELEQKAEE----AEALLKEAEKL---KEELEEKKEKLQEEEDKLLEE---AE 572
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1755 EKAKKAItdaammaEELKKEQDtsahlermkknmeQTIKDLQHRLD-EAEQIALKGGKKQLQKLEARVRELENELEAEQK 1833
Cdd:PRK00409  573 KEAQQAI-------KEAKKEAD-------------EIIKELRQLQKgGYASVKAHELIEARKRLNKANEKKEKKKKKQKE 632
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1834 RNAESVKGMrkserRIKELTY-QTEE-----DKKNLMrLQDLVDKLQLK---VKAYKRQAEEAEEQANTNLSKFRKVQHE 1904
Cdd:PRK00409  633 KQEELKVGD-----EVKYLSLgQKGEvlsipDDKEAI-VQAGIMKMKVPlsdLEKIQKPKKKKKKKPKTVKPKPRTVSLE 706
                         250
                  ....*....|....*..
gi 6754774   1905 LDEAEERADIAESQVNK 1921
Cdd:PRK00409  707 LDLRGMRYEEALERLDK 723
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
1003-1187 2.03e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 44.92  E-value: 2.03e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1003 EAHQQALDDLQAEEDKVNTLTKSKVKLEQQVDDLEGSLEQekkvrmdLERAKRKLEGDLKLTQESIMDLENDKLQLEEKL 1082
Cdd:COG1579    3 PEDLRALLDLQELDSELDRLEHRLKELPAELAELEDELAA-------LEARLEAAKTELEDLEKEIKRLELEIEEVEARI 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1083 KKKEfdiSQQNSKIEDEQALALQ-----LQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGG 1157
Cdd:COG1579   76 KKYE---EQLGNVRNNKEYEALQkeiesLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELA 152
                        170       180       190
                 ....*....|....*....|....*....|
gi 6754774  1158 ATSVQIEmnkKREAEFQKMRRDLEEATLQH 1187
Cdd:COG1579  153 ELEAELE---ELEAEREELAAKIPPELLAL 179
HCR pfam07111
Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha ...
869-1336 2.20e-04

Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha helical coiled-coil rod HCR proteins. The function of HCR is unknown but it has been implicated in psoriasis in humans and is thought to affect keratinocyte proliferation.


Pssm-ID: 284517 [Multi-domain]  Cd Length: 749  Bit Score: 46.28  E-value: 2.20e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     869 EARRKELEEKMVSLLQEKNDLQLQVQAEQDNLndaeercdQLIKNKIQLEAkvKEMTERLEDEEEMNAELTAKKRKLede 948
Cdd:pfam07111  241 ELERQELLDTMQHLQEDRADLQATVELLQVRV--------QSLTHMLALQE--EELTRKIQPSDSLEPEFPKKCRSL--- 307
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     949 cseLKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTL------ 1022
Cdd:pfam07111  308 ---LNRWREKVFALMVQLKAQDLEHRDSVKQLRGQVAELQEQVTSQSQEQAILQRALQDKAAEVEVERMSAKGLqmelsr 384
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1023 -TKSKVKLEQQVDDLEgslEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKefdisqqnskiedeQA 1101
Cdd:pfam07111  385 aQEARRRQQQQTASAE---EQLKFVVNAMSSTQIWLETTMTRVEQAVARIPSLSNRLSYAVRKV--------------HT 447
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1102 LALQLQKKLKENQARIEELEEELEaertarakVEKLRSDLSRELEEISE---RL--EEAGGATSVQIEMNKKREaEFQKM 1176
Cdd:pfam07111  448 IKGLMARKVALAQLRQESCPPPPP--------APPVDADLSLELEQLREernRLdaELQLSAHLIQQEVGRARE-QGEAE 518
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1177 RRDLEEATLQHEATAaalrKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELddvtsNMEQIIKAKANLEKVSRT--- 1253
Cdd:pfam07111  519 RQQLSEVAQQLEQEL----QRAQESLASVGQQLEVARQGQQESTEEAASLRQEL-----TQQQEIYGQALQEKVAEVetr 589
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1254 LEDQANEYRVKLEEAQR-------SLNDFTTQRAKLQTENGELARQLEEkealisqltrgklSYTQQMEDLKRQLEEEGK 1326
Cdd:pfam07111  590 LREQLSDTKRRLNEARReqakavvSLRQIQHRATQEKERNQELRRLQDE-------------ARKEEGQRLARRVQELER 656
                          490
                   ....*....|
gi 6754774    1327 AKNALAHALQ 1336
Cdd:pfam07111  657 DKNLMLATLQ 666
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
1131-1430 2.22e-04

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 46.48  E-value: 2.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1131 RAKVEKLRSDLSRELEEISERLEEAggATSVQiemnkkreaEFQKMRRDLEEATLQH---------EATAAALRKKHADS 1201
Cdd:COG3096  780 RAAREKRLEELRAERDELAEQYAKA--SFDVQ---------KLQRLHQAFSQFVGGHlavafapdpEAELAALRQRRSEL 848
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1202 VAELGEQIDNLQRVKQKLEKEKSEFKL------------------ELDDVTSNMEQIIKAKANLEKVSRTLEdqaneyrv 1263
Cdd:COG3096  849 ERELAQHRAQEQQLRQQLDQLKEQLQLlnkllpqanlladetladRLEELREELDAAQEAQAFIQQHGKALA-------- 920
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1264 KLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLT-----RGKLSYtqqmEDLKRQLEEEGKAKNALAHALQSS 1338
Cdd:COG3096  921 QLEPLVAVLQSDPEQFEQLQADYLQAKEQQRRLKQQIFALSevvqrRPHFSY----EDAVGLLGENSDLNEKLRARLEQA 996
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1339 RHDCDLLREQYEEEMEAKAELQRVLSKANSevaQWRTKYET--DAIQRTEELE-----EAKKKLAQRLQDAEEAVEAVNA 1411
Cdd:COG3096  997 EEARREAREQLRQAQAQYSQYNQVLASLKS---SRDAKQQTlqELEQELEELGvqadaEAEERARIRRDELHEELSQNRS 1073
                        330
                 ....*....|....*....
gi 6754774  1412 KCSSLEKTKHRLQNEIEDL 1430
Cdd:COG3096 1074 RRSQLEKQLTRCEAEMDSL 1092
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
971-1336 2.56e-04

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 46.16  E-value: 2.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    971 HATENKVKNLTEEMAGLDEIiakLTKEKKALQEAHQQALDDLQAEEDK---------VNTLTKSKVKLEQQVDDLEGSLE 1041
Cdd:NF033838   36 HAEEVRGGNNPTVTSSGNES---QKEHAKEVESHLEKILSEIQKSLDKrkhtqnvalNKKLSDIKTEYLYELNVLKEKSE 112
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1042 QE--KKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKK---------------------EFDISQQNSKIED 1098
Cdd:NF033838  113 AEltSKTKKELDAAFEQFKKDTLEPGKKVAEATKKVEEAEKKAKDQkeedrrnyptntyktleleiaESDVEVKKAELEL 192
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1099 EQALALQLQKKLKENQARIEELEEELEAERTARAKVEKlrsdlsrelEEISERLEEAGGATSVQIEMNKKREAEFQKMRR 1178
Cdd:NF033838  193 VKEEAKEPRDEEKIKQAKAKVESKKAEATRLEKIKTDR---------EKAEEEAKRRADAKLKEAVEKNVATSEQDKPKR 263
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1179 DLEEATLQHEATAAALRKKHADSVAELGEQidNLQRVKQKLEKEKSEFKLELDDVTSnmeqiiKAKANLEKVSR------ 1252
Cdd:NF033838  264 RAKRGVLGEPATPDKKENDAKSSDSSVGEE--TLPSPSLKPEKKVAEAEKKVEEAKK------KAKDQKEEDRRnyptnt 335
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1253 --TLEDQANEYRVKLEEAQRSLndfTTQRAKlQTENGELARQ----LEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGK 1326
Cdd:NF033838  336 ykTLELEIAESDVKVKEAELEL---VKEEAK-EPRNEEKIKQakakVESKKAEATRLEKIKTDRKKAEEEAKRKAAEEDK 411
                         410
                  ....*....|
gi 6754774   1327 AKNALAHALQ 1336
Cdd:NF033838  412 VKEKPAEQPQ 421
Yuri_gagarin pfam15934
Yuri gagarin; The yuri gagarin protein found in Drosophila, it plays roles in spermatogenesis.
870-1024 2.57e-04

Yuri gagarin; The yuri gagarin protein found in Drosophila, it plays roles in spermatogenesis.


Pssm-ID: 318204 [Multi-domain]  Cd Length: 234  Bit Score: 44.57  E-value: 2.57e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     870 ARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQL---------------IKNKI--------QLEAKVKEMTE 926
Cdd:pfam15934   41 ENKNEQEQQLKEFTVQNQRLACQIDNLHETLKDRDHQIKQLqsmitgysdisennrLKEEIhdlkqkncVQARVVRKMGL 120
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     927 RLEDEEEMNAELTAKKRKL----EDECSELK---KDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLdeiiakltKEKK 999
Cdd:pfam15934  121 ELKGQEEQRVELCDKYESLlgsfEEQCQELKranRRVQSLQTRLSQVEKLQEELRTERKILREEVIAL--------KEKD 192
                          170       180
                   ....*....|....*....|....*....
gi 6754774    1000 ALQEAHQQALDD----LQAEEDKVNTLTK 1024
Cdd:pfam15934  193 AKSNGRERALQDqlkcCQTEIEKSRTLIR 221
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1527-1743 2.64e-04

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 46.16  E-value: 2.64e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1527 ELEKIRKQLEVEKLELQSALEEAEASLEH-----------EEGKILRAQLefnqikAEIERKLAEKDEEMEQAKRNhlrm 1595
Cdd:COG3206  172 EARKALEFLEEQLPELRKELEEAEAALEEfrqknglvdlsEEAKLLLQQL------SELESQLAEARAELAEAEAR---- 241
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1596 VDSLQTSLDAETRSRNEALR--VKKKMEGDLNEMEIQLSQANRIASEAQKHLKNSQAHLKDTQLQLDDAVHAN-DDLKEN 1672
Cdd:COG3206  242 LAALRAQLGSGPDALPELLQspVIQQLRAQLAELEAELAELSARYTPNHPDVIALRAQIAALRAQLQQEAQRIlASLEAE 321
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6754774  1673 IAIVERRNNLLQAELEELRAVVEQTERsrklAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQTEV 1743
Cdd:COG3206  322 LEALQAREASLQAQLAQLEARLAELPE----LEAELRRLEREVEVARELYESLLQRLEEARLAEALTVGNV 388
PRK01156 PRK01156
chromosome segregation protein; Provisional
1050-1588 2.73e-04

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 46.05  E-value: 2.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1050 LERAKRKLEGDLKLTQESIMDLENdklqLEEKLKKKEFDISQQNSKIEDEQALALQLQKKLKENQARIEELEEELEAERT 1129
Cdd:PRK01156  164 LERNYDKLKDVIDMLRAEISNIDY----LEEKLKSSNLELENIKKQIADDEKSHSITLKEIERLSIEYNNAMDDYNNLKS 239
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1130 A--------------RAKVEKLRSDLSRELEE---ISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAA 1192
Cdd:PRK01156  240 AlnelssledmknryESEIKTAESDLSMELEKnnyYKELEERHMKIINDPVYKNRNYINDYFKYKNDIENKKQILSNIDA 319
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1193 ALRKKHADSVAELGEQIDNLQRVKQKleKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSL 1272
Cdd:PRK01156  320 EINKYHAIIKKLSVLQKDYNDYIKKK--SRYDDLNNQILELEGYEMDYNSYLKSIESLKKKIEEYSKNIERMSAFISEIL 397
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1273 NDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEE-EGKAKNALAH---ALQSSRHdcdlLREQ 1348
Cdd:PRK01156  398 KIQEIDPDAIKKELNEINVKLQDISSKVSSLNQRIRALRENLDELSRNMEMlNGQSVCPVCGttlGEEKSNH----IINH 473
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1349 YEEEM----EAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQ-------------RLQDAEEAVEAVNA 1411
Cdd:PRK01156  474 YNEKKsrleEKIREIEIEVKDIDEKIVDLKKRKEYLESEEINKSINEYNKIESaradledikikinELKDKHDKYEEIKN 553
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1412 KCSSLEKTKHRLQNEiEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYE 1491
Cdd:PRK01156  554 RYKSLKLEDLDSKRT-SWLNALAVISLIDIETNRSRSNEIKKQLNDLESRLQEIEIGFPDDKSYIDKSIREIENEANNLN 632
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1492 ESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKIRKQL---EVEKLELQSALEEAEASLEHEEG--KILRAQL- 1565
Cdd:PRK01156  633 NKYNEIQENKILIEKLRGKIDNYKKQIAEIDSIIPDLKEITSRIndiEDNLKKSRKALDDAKANRARLEStiEILRTRIn 712
                         570       580
                  ....*....|....*....|...
gi 6754774   1566 EFNQIKAEIERKLaEKDEEMEQA 1588
Cdd:PRK01156  713 ELSDRINDINETL-ESMKKIKKA 734
PRK12704 PRK12704
phosphodiesterase; Provisional
1350-1461 2.90e-04

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 45.54  E-value: 2.90e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1350 EEEMEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIED 1429
Cdd:PRK12704   46 EAKKEAEAIKKEALLEAKEEIHKLRNEFEKELRERRNELQKLEKRLLQKEENLDRKLELLEKREEELEKKEKELEQKQQE 125
                          90       100       110
                  ....*....|....*....|....*....|..
gi 6754774   1430 lmvdversnaaaaaLDKKQRNFDKILAEWKQK 1461
Cdd:PRK12704  126 --------------LEKKEEELEELIEEQLQE 143
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1687-1911 2.93e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 46.06  E-value: 2.93e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1687 LEELRAVVEQTERSRKlAEQELIETSERVQLLhsqntslinqkkkmeSDLTQLQTEVEEAVQECRNAEE-----KAKKAI 1761
Cdd:COG4913  224 FEAADALVEHFDDLER-AHEALEDAREQIELL---------------EPIRELAERYAAARERLAELEYlraalRLWFAQ 287
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1762 TDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEaEQKRNAESVkg 1841
Cdd:COG4913  288 RRLELLEAELEELRAELARLEAELERLEARLDALREELDELEAQIRGNGGDRLEQLEREIERLERELE-ERERRRARL-- 364
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6754774  1842 mrksERRIKELTYQTEEDKKNLMRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRK----VQHELDEAEER 1911
Cdd:COG4913  365 ----EALLAALGLPLPASAEEFAALRAEAAALLEALEEELEALEEALAEAEAALRDLRRelreLEAEIASLERR 434
WEMBL pfam05701
Weak chloroplast movement under blue light; WEMBL consists of several plant proteins required ...
1386-1921 3.08e-04

Weak chloroplast movement under blue light; WEMBL consists of several plant proteins required for the chloroplast avoidance response under high intensity blue light. This avoidance response consists in the relocation of chloroplasts on the anticlinal side of exposed cells. Acts in association with PMI2 to maintain the velocity of chloroplast photo-relocation movement via the regulation of cp-actin filaments. Thus several member-sequences are described as "myosin heavy chain-like".


Pssm-ID: 461718 [Multi-domain]  Cd Length: 562  Bit Score: 45.79  E-value: 3.08e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1386 EELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKhrlqNEIEDLMVDVERsnaaaAALDKKQRNFDKILAEWKQKyees 1465
Cdd:pfam05701   42 LELEKVQEEIPEYKKQSEAAEAAKAQVLEELESTK----RLIEELKLNLER-----AQTEEAQAKQDSELAKLRVE---- 108
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1466 QSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVH-------ELEKIRKQLEVE 1538
Cdd:pfam05701  109 EMEQGIADEASVAAKAQLEVAKARHAAAVAELKSVKEELESLRKEYASLVSERDIAIKRAEeavsaskEIEKTVEELTIE 188
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1539 KLELQSALEEAEAS-LEHEEGKIlRAQLEFNQIKAEIERKLAEKDEEMEQAkRNHLRMVDSLQTSLDAetrsrNEALRVK 1617
Cdd:pfam05701  189 LIATKESLESAHAAhLEAEEHRI-GAALAREQDKLNWEKELKQAEEELQRL-NQQLLSAKDLKSKLET-----ASALLLD 261
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1618 KK------MEGDLNEMEIQLSQANRIASEAQKHLKNSQAHLKDTQLQLDdavHANDDLKENIAIVERrnnlLQAELEELR 1691
Cdd:pfam05701  262 LKaelaayMESKLKEEADGEGNEKKTSTSIQAALASAKKELEEVKANIE---KAKDEVNCLRVAAAS----LRSELEKEK 334
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1692 AVVEQTERSRKLA-------EQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQTEVEEAVQECRNAEEKAKKAITDa 1764
Cdd:pfam05701  335 AELASLRQREGMAsiavsslEAELNRTKSEIALVQAKEKEAREKMVELPKQLQQAAQEAEEAKSLAQAAREELRKAKEE- 413
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1765 ammAEELKKEQDT-SAHLERMKKNMEQTIkdlqhrldEAEQIALkggkkqlqkleARVRELEnelEAEQKRNAESVKGMR 1843
Cdd:pfam05701  414 ---AEQAKAAASTvESRLEAVLKEIEAAK--------ASEKLAL-----------AAIKALQ---ESESSAESTNQEDSP 468
                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6754774    1844 KSerrikeLTYQTEEDKKNLMRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNK 1921
Cdd:pfam05701  469 RG------VTLSLEEYYELSKRAHEAEELANKRVAEAVSQIEEAKESELRSLEKLEEVNREMEERKEALKIALEKAEK 540
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
863-1068 3.22e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 45.21  E-value: 3.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   863 DALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEErcdqliknkiQLEAKVKEMTERLEDEEEMNAELTAKK 942
Cdd:COG3883   16 PQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQA----------ELEALQAEIDKLQAEIAEAEAEIEERR 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   943 RKLEDECSELKK---DIDDLELTLAkvekEKHATE--NKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEED 1017
Cdd:COG3883   86 EELGERARALYRsggSVSYLDVLLG----SESFSDflDRLSALSKIADADADLLEELKADKAELEAKKAELEAKLAELEA 161
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 6754774  1018 KVNTLTKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESI 1068
Cdd:COG3883  162 LKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAA 212
CCDC22 pfam05667
Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 ...
1551-1864 3.34e-04

Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 (CCDC22) is involved in regulation of NF-kappa-B signalling; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. It is part of the OMMD/CCDC22/CCDC93 (CCC) complex, which interacts with the multisubunit WASH complex required for endosomal deposition of F-actin and cargo trafficking in conjunction with the retromer. This entry also includes CCDC22 homologs from animals and plants.


Pssm-ID: 461708 [Multi-domain]  Cd Length: 600  Bit Score: 45.40  E-value: 3.34e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1551 ASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHL--RMVDSLQTSLDAETRSRNEALRVKkkmeGDLNEMe 1628
Cdd:pfam05667  206 PSLLERNAAELAAAQEWEEEWNSQGLASRLTPEEYRKRKRTKLlkRIAEQLRSAALAGTEATSGASRSA----QDLAEL- 280
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1629 iqLSQANRIASEAQKHLKNSQ-AHLKDTQLQLDDAVHANDDLKENIAIVERRNNLlQAELEELRAVVEQTERSRKLAEQE 1707
Cdd:pfam05667  281 --LSSFSGSSTTDTGLTKGSRfTHTEKLQFTNEAPAATSSPPTKVETEEELQQQR-EEELEELQEQLEDLESSIQELEKE 357
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1708 LietservqllhsqntslinqkKKMESDLTQLQTEVEEavQECRNAEEKAKKAItdAAMMAEELKkeqDTSAHLERMKKN 1787
Cdd:pfam05667  358 I---------------------KKLESSIKQVEEELEE--LKEQNEELEKQYKV--KKKTLDLLP---DAEENIAKLQAL 409
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6754774    1788 MEQTIKDLQH--RLDEAEQIALkggkkqLQKLEaRVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLM 1864
Cdd:pfam05667  410 VDASAQRLVElaGQWEKHRVPL------IEEYR-ALKEAKSNKEDESQRKLEEIKELREKIKEVAEEAKQKEELYKQLV 481
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
913-1182 3.63e-04

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 45.50  E-value: 3.63e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     913 NKIQLEAKVKEM-TERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDeiI 991
Cdd:pfam17380  285 SERQQQEKFEKMeQERLRQEKEEKAREVERRRKLEEAEKARQAEMDRQAAIYAEQERMAMERERELERIRQEERKRE--L 362
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     992 AKLTKEKKALQEAHQQALDDLQAEEDKVN--------TLTKSKVKLEQQVDDLEGSLEQEKKVRMDLERAK----RKLEG 1059
Cdd:pfam17380  363 ERIRQEEIAMEISRMRELERLQMERQQKNervrqeleAARKVKILEEERQRKIQQQKVEMEQIRAEQEEARqrevRRLEE 442
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1060 DLKLTQESIMDLENDKLQLEEKLKKKEFDISQQNSKIEDEQAlalqlQKKLKENQARiEELEEELEAERTARAKVEKLRS 1139
Cdd:pfam17380  443 ERAREMERVRLEEQERQQQVERLRQQEEERKRKKLELEKEKR-----DRKRAEEQRR-KILEKELEERKQAMIEEERKRK 516
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*....
gi 6754774    1140 DLSRELEEIS------ERLEEAGGATSVQIEMNKKREAEfQKMRRDLEE 1182
Cdd:pfam17380  517 LLEKEMEERQkaiyeeERRREAEEERRKQQEMEERRRIQ-EQMRKATEE 564
PRK12704 PRK12704
phosphodiesterase; Provisional
991-1172 3.91e-04

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 45.15  E-value: 3.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    991 IAKLTKEKKaLQEAHQQALDDLQAEEDKVNTLTKSKVkleqqvddlegsLEQEKKVrmdlERAKRKLEGDLKLTQESIMD 1070
Cdd:PRK12704   24 VRKKIAEAK-IKEAEEEAKRILEEAKKEAEAIKKEAL------------LEAKEEI----HKLRNEFEKELRERRNELQK 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1071 LENDKLQLEEKLKKKEFDISQQNSKIEDEQALALQLQKKLKENQARIEELEEEleaertARAKVEKLrSDLSRE------ 1144
Cdd:PRK12704   87 LEKRLLQKEENLDRKLELLEKREEELEKKEKELEQKQQELEKKEEELEELIEE------QLQELERI-SGLTAEeakeil 159
                         170       180
                  ....*....|....*....|....*...
gi 6754774   1145 LEEISERLEEAGGATSVQIEMNKKREAE 1172
Cdd:PRK12704  160 LEKVEEEARHEAAVLIKEIEEEAKEEAD 187
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1029-1285 4.26e-04

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 45.39  E-value: 4.26e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1029 LEQQVDDLEGSL----EQEKKVRMDLERAKRKLEgDLKlTQESIMDLENDKLQLEEKLKkkefdisqqnskiedeqalal 1104
Cdd:COG3206  166 LELRREEARKALefleEQLPELRKELEEAEAALE-EFR-QKNGLVDLSEEAKLLLQQLS--------------------- 222
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1105 QLQKKLKENQARIeeleeeleaeRTARAKVEKLRSDLSRELEEISERLEEAggatsvqiemnkkreaEFQKMRRDLEEAT 1184
Cdd:COG3206  223 ELESQLAEARAEL----------AEAEARLAALRAQLGSGPDALPELLQSP----------------VIQQLRAQLAELE 276
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1185 LQHEATAAALRKKHADsVAELGEQIDNL-QRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRV 1263
Cdd:COG3206  277 AELAELSARYTPNHPD-VIALRAQIAALrAQLQQEAQRILASLEAELEALQAREASLQAQLAQLEARLAELPELEAELRR 355
                        250       260
                 ....*....|....*....|....*
gi 6754774  1264 ---KLEEAQRSLNDFTTQRAKLQTE 1285
Cdd:COG3206  356 lerEVEVARELYESLLQRLEEARLA 380
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
1424-1924 4.36e-04

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 45.12  E-value: 4.36e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1424 QNEIEDLMVDVERSNAAAAALDKKQRNFDKILAewKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLEtfkRE 1503
Cdd:pfam05557   20 QMELEHKRARIELEKKASALKRQLDRESDRNQE--LQKRIRLLEKREAEAEEALREQAELNRLKKKYLEALNKKL---NE 94
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1504 NKNLQEEISDLTEQLGEggknvhELEKIRKQLEVEKLELQSALEEAEASLEHEEGKILRAQlEFNQIKAEIERKLAEKDE 1583
Cdd:pfam05557   95 KESQLADAREVISCLKN------ELSELRRQIQRAELELQSTNSELEELQERLDLLKAKAS-EAEQLRQNLEKQQSSLAE 167
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1584 EMEQAKRNHLRMvdSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSQANRIaSEAQKHLKNSQAHLKDTQLQLDDAv 1663
Cdd:pfam05557  168 AEQRIKELEFEI--QSQEQDSEIVKNSKSELARIPELEKELERLREHNKHLNEN-IENKLLLKEEVEDLKRKLEREEKY- 243
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1664 handdlKENIAIVERRNNLLQAELEELravvEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQTEV 1743
Cdd:pfam05557  244 ------REEAATLELEKEKLEQELQSW----VKLAQDTGLNLRSPEDLSRRIEQLQQREIVLKEENSSLTSSARQLEKAR 313
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1744 EEAVQECRNAEEKakkaITDAAMMAEELK--------------KEQD-TSAHLERMKK--NMEQTIKDLQHRLDEAEQIA 1806
Cdd:pfam05557  314 RELEQELAQYLKK----IEDLNKKLKRHKalvrrlqrrvllltKERDgYRAILESYDKelTMSNYSPQLLERIEEAEDMT 389
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1807 LKgGKKQLQKLEARVRELENELEAeQKRNAESVKGMRKSERRiKELTYQTEEDKKNLMRLQDLVDKLQLKVKAYKRQAEE 1886
Cdd:pfam05557  390 QK-MQAHNEEMEAQLSVAEEELGG-YKQQAQTLERELQALRQ-QESLADPSYSKEEVDSLRRKLETLELERQRLREQKNE 466
                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*
gi 6754774    1887 AEE-------QANTNLSKFRKVQHELDEAEERADIAESQVNKLRA 1924
Cdd:pfam05557  467 LEMelerrclQGDYDPKKTKVLHLSMNPAAEAYQQRKNQLEKLQA 511
DUF4686 pfam15742
Domain of unknown function (DUF4686); This family of proteins is found in eukaryotes. Proteins ...
841-1091 4.37e-04

Domain of unknown function (DUF4686); This family of proteins is found in eukaryotes. Proteins in this family are typically between 498 and 775 amino acids in length. There is a conserved DLK sequence motif.


Pssm-ID: 464838 [Multi-domain]  Cd Length: 384  Bit Score: 44.67  E-value: 4.37e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     841 LLKSAETEKEMANMKEEFGRVKDALEKSEARRKELEEKMVSLLQ---------EKNDLQLQVQAEQDNLNDAEERCDQLI 911
Cdd:pfam15742   99 VLKQAQSIKSQNSLQEKLAQEKSRVADAEEKILELQQKLEHAHKvcltdtcilEKKQLEERIKEASENEAKLKQQYQEEQ 178
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     912 KNKIQLEAKVKEMTERLEDeeemnaeLTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEemagLDEII 991
Cdd:pfam15742  179 QKRKLLDQNVNELQQQVRS-------LQDKEAQLEMTNSQQQLRIQQQEAQLKQLENEKRKSDEHLKSNQE----LSEKL 247
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     992 AKLTKEKKALQEAHQQALDDLQAEEDKVNtltkskvkleqqvddlegslEQEKKVRMDLERAKRKLEGDLKLTQESIMDL 1071
Cdd:pfam15742  248 SSLQQEKEALQEELQQVLKQLDVHVRKYN--------------------EKHHHHKAKLRRAKDRLVHEVEQRDERIKQL 307
                          250       260
                   ....*....|....*....|
gi 6754774    1072 ENDKLQLEEKLKKKEFDISQ 1091
Cdd:pfam15742  308 ENEIGILQQQSEKEKAFQKQ 327
Spc7 smart00787
Spc7 kinetochore protein; This domain is found in cell division proteins which are required ...
904-1079 4.72e-04

Spc7 kinetochore protein; This domain is found in cell division proteins which are required for kinetochore-spindle association.


Pssm-ID: 197874 [Multi-domain]  Cd Length: 312  Bit Score: 44.62  E-value: 4.72e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774      904 EERCDQLIKNKIQLEAKVKEMTErleDEEEMNAELTakkrkledECSELKKDIDDLELTL-AKVEKEKHATENKVKNLTE 982
Cdd:smart00787  136 EWRMKLLEGLKEGLDENLEGLKE---DYKLLMKELE--------LLNSIKPKLRDRKDALeEELRQLKQLEDELEDCDPT 204
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774      983 EMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKSKVKLEQQVDDLEGSLEQEKKV-RMDLERAKRKLEGDL 1061
Cdd:smart00787  205 ELDRAKEKLKKLLQEIMIKVKKLEELEEELQELESKIEDLTNKKSELNTEIAEAEKKLEQCRGFtFKEIEKLKEQLKLLQ 284
                           170
                    ....*....|....*...
gi 6754774     1062 KLTQESIMDLENDKLQLE 1079
Cdd:smart00787  285 SLTGWKITKLSGNTLSMT 302
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
962-1172 4.88e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 44.82  E-value: 4.88e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   962 TLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKSKVKLEQQVDDLEGSLE 1041
Cdd:COG3883   10 TPAFADPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELG 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1042 ------QEKKVRMD--------------LERA---KRKLEGDLKLTQEsimdLENDKLQLEEKLKKKEFDISQQNSKIED 1098
Cdd:COG3883   90 eraralYRSGGSVSyldvllgsesfsdfLDRLsalSKIADADADLLEE----LKADKAELEAKKAELEAKLAELEALKAE 165
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6754774  1099 EQALALQLQKKLKENQARIeelEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAE 1172
Cdd:COG3883  166 LEAAKAELEAQQAEQEALL---AQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAAA 236
ClyA_Cry6Aa-like cd22656
Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes ...
936-1073 4.98e-04

Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes pesticidal Cry6Aa toxin from Bacillus thuringiensis, one of the many parasporal crystal (Cry) toxins produced during the sporulation phase of growth. Many of these proteins are toxic to numerous insect species and have been effectively used as proteinaceous insecticides to directly kill insect pests; some have been used to control insect growth on transgenic agricultural plants. Cry6Aa exists as a protoxin, which is activated by cleavage using trypsin. Structure studies for Cry6Aa support a mechanism of action by pore formation, similar to cytolysin A (ClyA)-type alpha pore-forming toxins (alpha-PFTs) such as HblB, and bioassay and mutation studies show that Cry6Aa is an active pore-forming toxin. Cry6Aa shows atypical features compared to other members of alpha-PFTs, including internal repeat sequences and small loop regions within major alpha helices.


Pssm-ID: 439154 [Multi-domain]  Cd Length: 309  Bit Score: 44.28  E-value: 4.98e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   936 AELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEII-AKLTKEKKALQeahQQALDDLQA 1014
Cdd:cd22656  110 EELEEAKKTIKALLDDLLKEAKKYQDKAAKVVDKLTDFENQTEKDQTALETLEKALkDLLTDEGGAIA---RKEIKDLQK 186
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6754774  1015 EEDKVNTLTKSKVK-----LEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLEN 1073
Cdd:cd22656  187 ELEKLNEEYAAKLKakideLKALIADDEAKLAAALRLIADLTAADTDLDNLLALIGPAIPALEK 250
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
1298-1580 5.31e-04

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 45.00  E-value: 5.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1298 ALISQLTRGKLSYTQQMEDLKRQLEEE--GKAKNALAHALQSSRHDcdlLREQYEEEMEAKAELQRVLSKANSEVAQWRT 1375
Cdd:NF033838   88 ALNKKLSDIKTEYLYELNVLKEKSEAEltSKTKKELDAAFEQFKKD---TLEPGKKVAEATKKVEEAEKKAKDQKEEDRR 164
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1376 KYETDAIqRTEELEEAKKKLaqRLQDAEEAVEAVNAKCSSLEKTkhrlqneIEDLMVDVERSNAAAAALDKKQRnfDKIL 1455
Cdd:NF033838  165 NYPTNTY-KTLELEIAESDV--EVKKAELELVKEEAKEPRDEEK-------IKQAKAKVESKKAEATRLEKIKT--DREK 232
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1456 AEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQL-----------GEGGKN 1524
Cdd:NF033838  233 AEEEAKRRADAKLKEAVEKNVATSEQDKPKRRAKRGVLGEPATPDKKENDAKSSDSSVGEETLpspslkpekkvAEAEKK 312
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6754774   1525 VHELEK----------------IRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAE 1580
Cdd:NF033838  313 VEEAKKkakdqkeedrrnyptnTYKTLELEIAESDVKVKEAELELVKEEAKEPRNEEKIKQAKAKVESKKAE 384
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
861-997 5.34e-04

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 44.85  E-value: 5.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   861 VKDALEKSEARRKELEEKmvsllqeknDLQLQVQAEQDNLNDAEERCDQLIKNKIQLEAKVKEMTERLEDEEEMNAELTA 940
Cdd:COG2433  378 IEEALEELIEKELPEEEP---------EAEREKEHEERELTEEEEEIRRLEEQVERLEAEVEELEAELEEKDERIERLER 448
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6754774   941 KKRKL----------EDECSELKKDIDDLELTLAKVEKEKHATENKVKNLtEEMAGLDE--------IIAKLTKE 997
Cdd:COG2433  449 ELSEArseerreirkDREISRLDREIERLERELEEERERIEELKRKLERL-KELWKLEHsgelvpvkVVEKFTKE 522
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
1133-1396 5.83e-04

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 44.92  E-value: 5.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1133 KVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKmrrDLEEATLQHEataaalrkkhaDSVAELGEQIDNL 1212
Cdd:PRK05771   47 KLRSLLTKLSEALDKLRSYLPKLNPLREEKKKVSVKSLEELIK---DVEEELEKIE-----------KEIKELEEEISEL 112
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1213 QRVKQKLEKEKSE------FKLELDDVTSN-MEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTE 1285
Cdd:PRK05771  113 ENEIKELEQEIERlepwgnFDLDLSLLLGFkYVSVFVGTVPEDKLEELKLESDVENVEYISTDKGYVYVVVVVLKELSDE 192
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1286 NGELARQLEEKEALISqlTRGKLSytQQMEDLKRQLEEEGKAKNALAHALqssrhdCDLLREQYEEEMEAKAELQRVLSK 1365
Cdd:PRK05771  193 VEEELKKLGFERLELE--EEGTPS--ELIREIKEELEEIEKERESLLEEL------KELAKKYLEELLALYEYLEIELER 262
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 6754774   1366 ANSEVAQWRTKYeTDAIQ------RTEELEEAKKKLA 1396
Cdd:PRK05771  263 AEALSKFLKTDK-TFAIEgwvpedRVKKLKELIDKAT 298
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
1704-1891 5.96e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 44.44  E-value: 5.96e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1704 AEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDT-SAHLE 1782
Cdd:COG3883   14 ADPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREElGERAR 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1783 RMKKNMEQT-----------IKDLQHRLDEAEQIAlKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKE 1851
Cdd:COG3883   94 ALYRSGGSVsyldvllgsesFSDFLDRLSALSKIA-DADADLLEELKADKAELEAKKAELEAKLAELEALKAELEAAKAE 172
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 6754774  1852 LTYQTEEDKKNLMRLQDLVDKLQLKVKAYKRQAEEAEEQA 1891
Cdd:COG3883  173 LEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAA 212
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
1235-1449 6.67e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 44.44  E-value: 6.67e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1235 SNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTrgklsytQQM 1314
Cdd:COG3883   16 PQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERR-------EEL 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1315 EDLKRQLEEEGKAKNALAhALQSSRHDCDLLReqyeeemeaKAELQRVLSKANSEVAQwrtkyetDAIQRTEELEEAKKK 1394
Cdd:COG3883   89 GERARALYRSGGSVSYLD-VLLGSESFSDFLD---------RLSALSKIADADADLLE-------ELKADKAELEAKKAE 151
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 6754774  1395 LAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQR 1449
Cdd:COG3883  152 LEAKLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELA 206
CHASE3 COG5278
Extracytoplasmic sensor domain CHASE3 (specificity unknown) [Signal transduction mechanisms];
1495-1933 6.81e-04

Extracytoplasmic sensor domain CHASE3 (specificity unknown) [Signal transduction mechanisms];


Pssm-ID: 444089 [Multi-domain]  Cd Length: 530  Bit Score: 44.51  E-value: 6.81e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1495 EHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKIRKQLEVEKLELQSAL--------EEAEASLEHEEGKILRAQLE 1566
Cdd:COG5278   76 SFLEPYEEARAEIDELLAELRSLTADNPEQQARLDELEALIDQWLAELEQVIalrragglEAALALVRSGEGKALMDEIR 155
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1567 FNQIKAEIERKLAEKDEEMEQAKRNHLRMVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSQANRIASEAQKHLK 1646
Cdd:COG5278  156 ARLLLLALALAALLLAAAALLLLLLALAALLALAELLLLALARALAALLLLLLLEAELAAAAALLAAAAALAALAALELL 235
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1647 NSQAHLKDTQLQLDDAVHANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLI 1726
Cdd:COG5278  236 AALALALALLLAALLLALLAALALAALLAAALLALAALLLALAAAAALAAAAALELAAAEALALAELELELLLAAAAAAA 315
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1727 NQKKKMESDLTQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIA 1806
Cdd:COG5278  316 AAAAAAAAALAALLALALATALAAAAAALALLAALLAEAAAAAAEEAEAAAEAAAAALAGLAEVEAEGAAEAVELEVLAI 395
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1807 LKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLMRLQDLVDKLQLKVKAYKRQAEE 1886
Cdd:COG5278  396 AAAAAAAAAEAAAAAAAAAAASAAEALELAEALAEALALAEEEALALAAASSELAEAGAALALAAAEALAEELAAVAALA 475
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*..
gi 6754774  1887 AEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDIGAKK 1933
Cdd:COG5278  476 ALAAAAAALAEAEAAAALAAAAALSLALALAALLLAAAEAALAAALA 522
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
1170-1332 7.33e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 44.05  E-value: 7.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1170 EAEFQKMRRDLEEATLQHEATAAALRKKHADsVAELGEQIDNLQrvkQKLEKEKSEFK---------------LE----- 1229
Cdd:COG3883   36 QAELDALQAELEELNEEYNELQAELEALQAE-IDKLQAEIAEAE---AEIEERREELGeraralyrsggsvsyLDvllgs 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1230 --LDDVTSNMEQIIK-AKANLEKVSRTLEDQAnEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRG 1306
Cdd:COG3883  112 esFSDFLDRLSALSKiADADADLLEELKADKA-ELEAKKAELEAKLAELEALKAELEAAKAELEAQQAEQEALLAQLSAE 190
                        170       180
                 ....*....|....*....|....*.
gi 6754774  1307 KLSYTQQMEDLKRQLEEEGKAKNALA 1332
Cdd:COG3883  191 EAAAEAQLAELEAELAAAEAAAAAAA 216
PRK12704 PRK12704
phosphodiesterase; Provisional
845-1000 7.95e-04

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 44.38  E-value: 7.95e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    845 AETEKEMANMKEEfgRVKDALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEErcdQLIKNKIQLEAKVKEM 924
Cdd:PRK12704   45 EEAKKEAEAIKKE--ALLEAKEEIHKLRNEFEKELRERRNELQKLEKRLLQKEENLDRKLE---LLEKREEELEKKEKEL 119
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    925 TERLEDEEEMNAELTAKKRKLEDE---CSELKKDiDDLELTLAKVEKE-KHATENKVKNLTEEmagldeiiAKLTKEKKA 1000
Cdd:PRK12704  120 EQKQQELEKKEEELEELIEEQLQElerISGLTAE-EAKEILLEKVEEEaRHEAAVLIKEIEEE--------AKEEADKKA 190
Filament pfam00038
Intermediate filament protein;
1282-1587 8.29e-04

Intermediate filament protein;


Pssm-ID: 459643 [Multi-domain]  Cd Length: 313  Bit Score: 43.76  E-value: 8.29e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1282 LQTENGELARQLEEKEALIS-QLTRGKLSYTQQMEDLKRQLEEEGKAKnalahalqssrhdcdllreqyeeemeAKAELQ 1360
Cdd:pfam00038   23 LEQQNKLLETKISELRQKKGaEPSRLYSLYEKEIEDLRRQLDTLTVER--------------------------ARLQLE 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1361 rvLSKANSEVAQWRTKYETDAIQRTEeLEEAKKKLAQRLQDAEEAVEAVNAKCSSLE------KTKHR-----LQNEIED 1429
Cdd:pfam00038   77 --LDNLRLAAEDFRQKYEDELNLRTS-AENDLVGLRKDLDEATLARVDLEAKIESLKeelaflKKNHEeevreLQAQVSD 153
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1430 LMVDVERSNAaaaaldkKQRNFDKILAEWKQKYEEsqselessqkearslstelfkLKNAYEESLEhlETFKRENKNLQE 1509
Cdd:pfam00038  154 TQVNVEMDAA-------RKLDLTSALAEIRAQYEE---------------------IAAKNREEAE--EWYQSKLEELQQ 203
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6754774    1510 EISDLTEQLGEGGKNVHELEKIRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQ 1587
Cdd:pfam00038  204 AAARNGDALRSAKEEITELRRTIQSLEIELQSLKKQKASLERQLAETEERYELQLADYQELISELEAELQETRQEMAR 281
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
983-1161 8.34e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 42.99  E-value: 8.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   983 EMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKSKVKLEQQVDDLEgslEQEKKVRMDLERAK-----RKL 1057
Cdd:COG1579   18 ELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVE---ARIKKYEEQLGNVRnnkeyEAL 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1058 EGDLKLTQESIMDLENDKLQLEEKLKKKEFDISQQNSKIEDEQALALQLQKKLKENQARIEELEEEleaertARAKVEKL 1137
Cdd:COG1579   95 QKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEE------LEAEREEL 168
                        170       180
                 ....*....|....*....|....
gi 6754774  1138 RSDLSRELEEISERLEEAGGATSV 1161
Cdd:COG1579  169 AAKIPPELLALYERIRKRKNGLAV 192
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
1790-1932 9.64e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 42.99  E-value: 9.64e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1790 QTIKDLQHRLDEAEQIA--LKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLMRLQ 1867
Cdd:COG1579    7 RALLDLQELDSELDRLEhrLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLGNVR 86
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6754774  1868 DL--VDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDIGAK 1932
Cdd:COG1579   87 NNkeYEALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAE 153
Caldesmon pfam02029
Caldesmon;
1605-1888 9.98e-04

Caldesmon;


Pssm-ID: 460421 [Multi-domain]  Cd Length: 495  Bit Score: 44.09  E-value: 9.98e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1605 AETRSRNEALRVKKKMEGDLNEMEIQLSQANRIASEAQKHLKNSQahlkDTQLQLDDAvhaNDDLKENIAIVERRNNLLQ 1684
Cdd:pfam02029   39 NEHNSYEEDSELKPSGQGGLDEEEAFLDRTAKREERRQKRLQEAL----ERQKEFDPT---IADEKESVAERKENNEEEE 111
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1685 AELEELRAVVEQTERSRKLAEQELIETSERVQLLHsQNTSLINQKKKMESDLTQLQTEVE------EAVQECRNAEEKAK 1758
Cdd:pfam02029  112 NSSWEKEEKRDSRLGRYKEEETEIREKEYQENKWS-TEVRQAEEEGEEEEDKSEEAEEVPtenfakEEVKDEKIKKEKKV 190
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1759 KAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDL----QHRLDEAEQIALKGGKKQLQKLEARVRELENElEAEQKR 1834
Cdd:pfam02029  191 KYESKVFLDQKRGHPEVKSQNGEEEVTKLKVTTKRRQgglsQSQEREEEAEVFLEAEQKLEELRRRRQEKESE-EFEKLR 269
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6754774    1835 NA--------ESVKGMRKSERRIKELTYQTEEDKKNLMRLQDLVDKLQLKVKAYKRQAEEAE 1888
Cdd:pfam02029  270 QKqqeaelelEELKKKREERRKLLEEEEQRRKQEEAERKLREEEEKRRMKEEIERRRAEAAE 331
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
1768-1919 1.02e-03

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 44.08  E-value: 1.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1768 AEELKKEQDTSAHLERMKKNMEQTIKDLQhrldeaeqialkggkKQLQKLEARVRELENELEAEQKRNAES---VKGMRK 1844
Cdd:COG2433  391 PEEEPEAEREKEHEERELTEEEEEIRRLE---------------EQVERLEAEVEELEAELEEKDERIERLereLSEARS 455
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1845 SERR-------IKELTYQTEEDKKNLMRLQDLVDKLQLKVKAYKRqAEEAEEQANT----NLSKFRKvqHELDEAEERAD 1913
Cdd:COG2433  456 EERReirkdreISRLDREIERLERELEEERERIEELKRKLERLKE-LWKLEHSGELvpvkVVEKFTK--EAIRRLEEEYG 532

                 ....*.
gi 6754774  1914 IAESQV 1919
Cdd:COG2433  533 LKEGDV 538
PRK12704 PRK12704
phosphodiesterase; Provisional
867-1015 1.08e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 44.00  E-value: 1.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    867 KSEARRKELEEKMVSLLQEKNdlqlqvqaeqdnlNDAEErcdqlIKNKIQLEAK--VKEMTERLEDE-EEMNAELTAKKR 943
Cdd:PRK12704   28 IAEAKIKEAEEEAKRILEEAK-------------KEAEA-----IKKEALLEAKeeIHKLRNEFEKElRERRNELQKLEK 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    944 KLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAK----------LTKEkkalqEAHQQALDDLQ 1013
Cdd:PRK12704   90 RLLQKEENLDRKLELLEKREEELEKKEKELEQKQQELEKKEEELEELIEEqlqelerisgLTAE-----EAKEILLEKVE 164

                  ..
gi 6754774   1014 AE 1015
Cdd:PRK12704  165 EE 166
46 PHA02562
endonuclease subunit; Provisional
976-1223 1.14e-03

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 43.85  E-value: 1.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    976 KVKNLTEEMAGLD----EIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKSKVKLEQQVDDLEgslEQEKKVRMDLE 1051
Cdd:PHA02562  175 KIRELNQQIQTLDmkidHIQQQIKTYNKNIEEQRKKNGENIARKQNKYDELVEEAKTIKAEIEELT---DELLNLVMDIE 251
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1052 rakrKLEGDL-KLTQESI-MDLENDKLQLEEKLKKK-------EFDISQQNSKIEDEQALALQLQKKLKENQARIEELEE 1122
Cdd:PHA02562  252 ----DPSAALnKLNTAAAkIKSKIEQFQKVIKMYEKggvcptcTQQISEGPDRITKIKDKLKELQHSLEKLDTAIDELEE 327
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1123 ELEAERTARAKVEKLRSDLSRELEEISERLEEAggatsvqiemnKKREAEFQKmrrdleeatlqheatAAALRKKHADSV 1202
Cdd:PHA02562  328 IMDEFNEQSKKLLELKNKISTNKQSLITLVDKA-----------KKVKAAIEE---------------LQAEFVDNAEEL 381
                         250       260
                  ....*....|....*....|.
gi 6754774   1203 AELGEQIDNLQRVKQKLEKEK 1223
Cdd:PHA02562  382 AKLQDELDKIVKTKSELVKEK 402
PRK01156 PRK01156
chromosome segregation protein; Provisional
1329-1889 1.19e-03

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 44.12  E-value: 1.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1329 NALAHALQSSRHDCDLLREQYEEEMEAKAELQRVLSKANSEVAQWRTKYE--TDAIQRTEELEEAKKKLAQRLQDAEEAV 1406
Cdd:PRK01156  186 DYLEEKLKSSNLELENIKKQIADDEKSHSITLKEIERLSIEYNNAMDDYNnlKSALNELSSLEDMKNRYESEIKTAESDL 265
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1407 EAVNAKCSSLEKTKHRLqNEIEDLMVDVERSNAAAAALDKKQ-RNFDKILAEWK---QKYEESQSELEssqkEARSLSTE 1482
Cdd:PRK01156  266 SMELEKNNYYKELEERH-MKIINDPVYKNRNYINDYFKYKNDiENKKQILSNIDaeiNKYHAIIKKLS----VLQKDYND 340
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1483 LFKLKNAYEE---SLEHLETFKRENKNLQEEISDLTEQLGEGGKNVH----ELEKIRKQLEVEKLELQSALEEAEASLEH 1555
Cdd:PRK01156  341 YIKKKSRYDDlnnQILELEGYEMDYNSYLKSIESLKKKIEEYSKNIErmsaFISEILKIQEIDPDAIKKELNEINVKLQD 420
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1556 EEGKILraqlEFNQIKAEIERKLAEKDEEMEQAKRNHLRMVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSQAN 1635
Cdd:PRK01156  421 ISSKVS----SLNQRIRALRENLDELSRNMEMLNGQSVCPVCGTTLGEEKSNHIINHYNEKKSRLEEKIREIEIEVKDID 496
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1636 riasEAQKHLKNSQAHLkdtqlqlddavhANDDLKENIAiVERRNNLLQAELEELRaVVEQTERSRKLAEQELIE--TSE 1713
Cdd:PRK01156  497 ----EKIVDLKKRKEYL------------ESEEINKSIN-EYNKIESARADLEDIK-IKINELKDKHDKYEEIKNryKSL 558
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1714 RVQLLHSQNTSLINQKKKMES-DLTQLQTEVEEAVQECRNAEEKakkaitdaamMAEELKKEQDTSAHLERMKKNMEQTI 1792
Cdd:PRK01156  559 KLEDLDSKRTSWLNALAVISLiDIETNRSRSNEIKKQLNDLESR----------LQEIEIGFPDDKSYIDKSIREIENEA 628
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1793 KDLQHRLDEAEqiALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLMRLQDLVDK 1872
Cdd:PRK01156  629 NNLNNKYNEIQ--ENKILIEKLRGKIDNYKKQIAEIDSIIPDLKEITSRINDIEDNLKKSRKALDDAKANRARLESTIEI 706
                         570
                  ....*....|....*..
gi 6754774   1873 LQLKVKAYKRQAEEAEE 1889
Cdd:PRK01156  707 LRTRINELSDRINDINE 723
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
1779-1925 1.21e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 42.60  E-value: 1.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1779 AHLERMKKNMEQTIKDLQHRLDEAEQiALKGGKKQLQKLEARVRELENELEAEQKRNAESVK--GMRKSERRIKELTYQT 1856
Cdd:COG1579   20 DRLEHRLKELPAELAELEDELAALEA-RLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEqlGNVRNNKEYEALQKEI 98
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6754774  1857 EEDKKNLMRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAK 1925
Cdd:COG1579   99 ESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELEAEREE 167
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
1189-1372 1.25e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 43.28  E-value: 1.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1189 ATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELD----DVTSNMEQIIKAKANLEKVSRTLEDQANEYRVK 1264
Cdd:COG3883   12 AFADPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNelqaELEALQAEIDKLQAEIAEAEAEIEERREELGER 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1265 LEEAQR---------------SLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKN 1329
Cdd:COG3883   92 ARALYRsggsvsyldvllgseSFSDFLDRLSALSKIADADADLLEELKADKAELEAKKAELEAKLAELEALKAELEAAKA 171
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 6754774  1330 ALAHALQSSRHDCDLLREQYEEEMEAKAELQRVLSKANSEVAQ 1372
Cdd:COG3883  172 ELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAA 214
HEC1 COG5185
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
1434-1707 1.28e-03

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 43.79  E-value: 1.28e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1434 VERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARslstelFKLKNAYEESLEHLETfkrENKNLQEEISD 1513
Cdd:COG5185  277 SKRLNENANNLIKQFENTKEKIAEYTKSIDIKKATESLEEQLAA------AEAEQELEESKRETET---GIQNLTAEIEQ 347
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1514 LTEQLGEGgknvheLEKIRKqlEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHL 1593
Cdd:COG5185  348 GQESLTEN------LEAIKE--EIENIVGEVELSKSSEELDSFKDTIESTKESLDEIPQNQRGYAQEILATLEDTLKAAD 419
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1594 RMVDSLQTSLDAETRSRNEALRVKKKMEGDLNEM--EIQLSQANRIASEAQKHLKNSQAHLKDTQLQLDDAVHANDDLKE 1671
Cdd:COG5185  420 RQIEELQRQIEQATSSNEEVSKLLNELISELNKVmrEADEESQSRLEEAYDEINRSVRSKKEDLNEELTQIESRVSTLKA 499
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 6754774  1672 NiaiVERRNNLLQAELEELRAVVEQTERSRKLAEQE 1707
Cdd:COG5185  500 T---LEKLRAKLERQLEGVRSKLDQVAESLKDFMRA 532
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
852-1175 1.49e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 42.97  E-value: 1.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   852 ANMKEEFGRVKDALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKIQLEAKVKEMTERLEDE 931
Cdd:COG4372   27 AALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESL 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   932 EEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAH-QQALD 1010
Cdd:COG4372  107 QEEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQELQALSEAEaEQALD 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1011 DLQAEEDKVNTLTKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDIS 1090
Cdd:COG4372  187 ELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKEELLEEVILKEIEELELA 266
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1091 QQNSKIEDEQALALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKRE 1170
Cdd:COG4372  267 ILVEKDTEEEELEIAALELEALEEAALELKLLALLLNLAALSLIGALEDALLAALLELAKKLELALAILLAELADLLQLL 346

                 ....*
gi 6754774  1171 AEFQK 1175
Cdd:COG4372  347 LVGLL 351
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
1006-1870 1.50e-03

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 43.79  E-value: 1.50e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1006 QQALDDLQAEEDKVNTLTKSKVKLEQQVDDLEGSLEQEKKVRMDLERAkrklEGDLKLTQESimdlendkLQLEEKLKKK 1085
Cdd:COG3096  285 ERALELRRELFGARRQLAEEQYRLVEMARELEELSARESDLEQDYQAA----SDHLNLVQTA--------LRQQEKIERY 352
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1086 EFDISQQNSKIEDEQALALQLQKKLKENQARieeleeeleaERTARAKVEKLRSDLSReleeiserLEEAggatsvqIEM 1165
Cdd:COG3096  353 QEDLEELTERLEEQEEVVEEAAEQLAEAEAR----------LEAAEEEVDSLKSQLAD--------YQQA-------LDV 407
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1166 NKKREAEFQKMRRDLEEATLQHEA---TAAALRKKHADSVAELGEQIDNLQRVKQKLekeksefklelDDVTSNMEQIIK 1242
Cdd:COG3096  408 QQTRAIQYQQAVQALEKARALCGLpdlTPENAEDYLAAFRAKEQQATEEVLELEQKL-----------SVADAARRQFEK 476
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1243 AKANLEKVSRTLE-DQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTR------GKLSYTQQME 1315
Cdd:COG3096  477 AYELVCKIAGEVErSQAWQTARELLRRYRSQQALAQRLQQLRAQLAELEQRLRQQQNAERLLEEfcqrigQQLDAAEELE 556
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1316 DLKRQLEEEGKAKNALAHALQSSRHDCDLLREQYEEEMEAKAELQRVLSKANSEVAQWRTkyetdaiQRTEELEEAKKKL 1395
Cdd:COG3096  557 ELLAELEAQLEELEEQAAEAVEQRSELRQQLEQLRARIKELAARAPAWLAAQDALERLRE-------QSGEALADSQEVT 629
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1396 AQRLQDAEEAVEAVNAKcSSLEKTKHRLQNEIEDLmvdversNAAAAALDKKQRNfdkiLAEwkqkyeesqselessqKE 1475
Cdd:COG3096  630 AAMQQLLEREREATVER-DELAARKQALESQIERL-------SQPGGAEDPRLLA----LAE----------------RL 681
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1476 ARSLSTELFK---LKNA-YEESL----------EHLETFKRENKNLQEEISDLteQLGEGGKN--------VHELEK--- 1530
Cdd:COG3096  682 GGVLLSEIYDdvtLEDApYFSALygparhaivvPDLSAVKEQLAGLEDCPEDL--YLIEGDPDsfddsvfdAEELEDavv 759
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1531 -------IR----------------KQLEVEKLELQsALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEME- 1586
Cdd:COG3096  760 vklsdrqWRysrfpevplfgraareKRLEELRAERD-ELAEQYAKASFDVQKLQRLHQAFSQFVGGHLAVAFAPDPEAEl 838
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1587 QAKRNHLRMVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMeiqLSQANRIASEaqkHLknsQAHLKDTQLQLDDAVHAN 1666
Cdd:COG3096  839 AALRQRRSELERELAQHRAQEQQLRQQLDQLKEQLQLLNKL---LPQANLLADE---TL---ADRLEELREELDAAQEAQ 909
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1667 DDLKEN---IAIVERRNNLLQ---AELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLT-QL 1739
Cdd:COG3096  910 AFIQQHgkaLAQLEPLVAVLQsdpEQFEQLQADYLQAKEQQRRLKQQIFALSEVVQRRPHFSYEDAVGLLGENSDLNeKL 989
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1740 QTEVEEAVQECRNAEEKAKKA---ITDAAMMAEELKKEQDTSAhleRMKKNMEQTIKDLQHRLD-EAEQIAlKGGKKQLQ 1815
Cdd:COG3096  990 RARLEQAEEARREAREQLRQAqaqYSQYNQVLASLKSSRDAKQ---QTLQELEQELEELGVQADaEAEERA-RIRRDELH 1065
                        890       900       910       920       930
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 6754774  1816 KLEARVRELENELEAE-QKRNAES---VKGMRKSERRIKELTYQTEEDKKNLMRLQDLV 1870
Cdd:COG3096 1066 EELSQNRSRRSQLEKQlTRCEAEMdslQKRLRKAERDYKQEREQVVQAKAGWCAVLRLA 1124
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
875-1112 1.51e-03

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 43.38  E-value: 1.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    875 LEEKMVSLLQEKNDLQLqVQAEQDNLNDAEERcdqlIKNKIQLEAKVKEMTERLEDEeeMNAELTAKKRKLEDECSELKK 954
Cdd:PRK05771   14 LKSYKDEVLEALHELGV-VHIEDLKEELSNER----LRKLRSLLTKLSEALDKLRSY--LPKLNPLREEKKKVSVKSLEE 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    955 DIDDLELTLAKVEKEkhatenkVKNLTEEMAGLDEIIAKLTKEKKALQ--EAHQQALDDLQAEED---KVNTLTKSKVKL 1029
Cdd:PRK05771   87 LIKDVEEELEKIEKE-------IKELEEEISELENEIKELEQEIERLEpwGNFDLDLSLLLGFKYvsvFVGTVPEDKLEE 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1030 EQQVDDLEGSLEQEKK------VRMDLERAKRKLEGDLKLTQESIMDLENDKLqLEEKLKKKEFDISQQNSKIEDeqala 1103
Cdd:PRK05771  160 LKLESDVENVEYISTDkgyvyvVVVVLKELSDEVEEELKKLGFERLELEEEGT-PSELIREIKEELEEIEKERES----- 233

                  ....*....
gi 6754774   1104 lqLQKKLKE 1112
Cdd:PRK05771  234 --LLEELKE 240
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
1383-1591 1.58e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 42.89  E-value: 1.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1383 QRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAaaaLDKKQRNFDKIL-AEWKQK 1461
Cdd:COG3883   23 KELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAE---IEERREELGERArALYRSG 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1462 YEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEggknvheLEKIRKQLEVEKLE 1541
Cdd:COG3883  100 GSVSYLDVLLGSESFSDFLDRLSALSKIADADADLLEELKADKAELEAKKAELEAKLAE-------LEALKAELEAAKAE 172
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 6754774  1542 LQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRN 1591
Cdd:COG3883  173 LEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAA 222
46 PHA02562
endonuclease subunit; Provisional
889-1161 1.63e-03

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 43.46  E-value: 1.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    889 LQLQVQAEQDNLNDAEER--------CDQLIKNkiqLEAKVKEMTERLEDEEEMNAELTAKKR----KLEDECSELKKDI 956
Cdd:PHA02562  160 LDISVLSEMDKLNKDKIRelnqqiqtLDMKIDH---IQQQIKTYNKNIEEQRKKNGENIARKQnkydELVEEAKTIKAEI 236
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    957 DDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQ-----QALDDlqaEEDKVNTLTKSKVKLEQ 1031
Cdd:PHA02562  237 EELTDELLNLVMDIEDPSAALNKLNTAAAKIKSKIEQFQKVIKMYEKGGVcptctQQISE---GPDRITKIKDKLKELQH 313
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1032 QVDDLEGSLEQEKKVRMDLERAKRKlegdlkltqesIMDLENDklqleeklkkkefdISQQNSKIEDEQALALQLQKKLK 1111
Cdd:PHA02562  314 SLEKLDTAIDELEEIMDEFNEQSKK-----------LLELKNK--------------ISTNKQSLITLVDKAKKVKAAIE 368
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 6754774   1112 ENQARIEELEEELEAERTARAKVEKLRSDLSRELEE---ISERLEEAGGATSV 1161
Cdd:PHA02562  369 ELQAEFVDNAEELAKLQDELDKIVKTKSELVKEKYHrgiVTDLLKDSGIKASI 421
PLN03188 PLN03188
kinesin-12 family protein; Provisional
1684-1925 1.68e-03

kinesin-12 family protein; Provisional


Pssm-ID: 215621 [Multi-domain]  Cd Length: 1320  Bit Score: 43.38  E-value: 1.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1684 QAELEELRAVVEQTERSRKLAE-QELietseRVQLLHSQNTSLINQKKK---------MESDLTQLQTEVEEAVQECrnA 1753
Cdd:PLN03188  973 QDELEHYRNFYDMGEREVLLEEiQDL-----RSQLQYYIDSSLPSARKRnsllkltysCEPSQAPPLNTIPESTDES--P 1045
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1754 EEKAKK-------AITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQK---------- 1816
Cdd:PLN03188 1046 EKKLEQerlrwteAESKWISLAEELRTELDASRALAEKQKHELDTEKRCAEELKEAMQMAMEGHARMLEQyadleekhiq 1125
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1817 LEARVRELENELEAEQKrnAESVKGMRKSERRI-----KELTYQTEEDKKNLMRLQDLVDKLQLKVkaykRQAEEAEEQA 1891
Cdd:PLN03188 1126 LLARHRRIQEGIDDVKK--AAARAGVRGAESKFinalaAEISALKVEREKERRYLRDENKSLQAQL----RDTAEAVQAA 1199
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 6754774   1892 NTNLSKFRKVQHELDEAEERADIAE-------SQVNKLRAK 1925
Cdd:PLN03188 1200 GELLVRLKEAEEALTVAQKRAMDAEqeaaeayKQIDKLKRK 1240
PRK11637 PRK11637
AmiB activator; Provisional
926-1155 1.78e-03

AmiB activator; Provisional


Pssm-ID: 236942 [Multi-domain]  Cd Length: 428  Bit Score: 43.14  E-value: 1.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    926 ERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATEnkvKNLTEEM---------AGLDEIIAKLTK 996
Cdd:PRK11637   75 AQLKKQEEAISQASRKLRETQNTLNQLNKQIDELNASIAKLEQQQAAQE---RLLAAQLdaafrqgehTGLQLILSGEES 151
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    997 EKKALQEAHQQALDdlQAEEDKVNTLTKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENdkl 1076
Cdd:PRK11637  152 QRGERILAYFGYLN--QARQETIAELKQTREELAAQKAELEEKQSQQKTLLYEQQAQQQKLEQARNERKKTLTGLES--- 226
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6754774   1077 qleeKLKKkefdisqqnskieDEQALAlqlqkKLKENQARIEELEEELEAERTARAKVEklrsdlSRELEEISERLEEA 1155
Cdd:PRK11637  227 ----SLQK-------------DQQQLS-----ELRANESRLRDSIARAEREAKARAERE------AREAARVRDKQKQA 277
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
1022-1429 1.93e-03

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 43.19  E-value: 1.93e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1022 LTKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDISQQ-----NSKI 1096
Cdd:pfam05557    4 LIESKARLSQLQNEKKQMELEHKRARIELEKKASALKRQLDRESDRNQELQKRIRLLEKREAEAEEALREQaelnrLKKK 83
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1097 EDEQALALQLQKKLKENQARiEELEEELEAERTARAKVEKLRSDLSR---ELEEISERLEE----AGGATSVQIEMNKKR 1169
Cdd:pfam05557   84 YLEALNKKLNEKESQLADAR-EVISCLKNELSELRRQIQRAELELQStnsELEELQERLDLlkakASEAEQLRQNLEKQQ 162
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1170 E--AEFQKMRRDLEEATLQHEATAAALRKKHAD--SVAEL----------GEQIDNLQRVKQKLEKEKSEFKLELDDVTS 1235
Cdd:pfam05557  163 SslAEAEQRIKELEFEIQSQEQDSEIVKNSKSElaRIPELekelerlrehNKHLNENIENKLLLKEEVEDLKRKLEREEK 242
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1236 NMEQIIKAKANLEKVSRTLE-----DQANEYRVKLEEAQRSLNDFTTQRAK-LQTENGELARQLEEKEALISQLTRGKLS 1309
Cdd:pfam05557  243 YREEAATLELEKEKLEQELQswvklAQDTGLNLRSPEDLSRRIEQLQQREIvLKEENSSLTSSARQLEKARRELEQELAQ 322
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1310 YTQQMEDLKRQLEEEGKAKNALAHALQSSRHDCDLLR---EQYEEEMeakaelqrvlskANSEVAQWRTKYETDAIQRTE 1386
Cdd:pfam05557  323 YLKKIEDLNKKLKRHKALVRRLQRRVLLLTKERDGYRailESYDKEL------------TMSNYSPQLLERIEEAEDMTQ 390
                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*
gi 6754774    1387 ELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEK--TKHRLQNEIED 1429
Cdd:pfam05557  391 KMQAHNEEMEAQLSVAEEELGGYKQQAQTLERelQALRQQESLAD 435
ClpA COG0542
ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein ...
955-1085 1.96e-03

ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440308 [Multi-domain]  Cd Length: 836  Bit Score: 43.15  E-value: 1.96e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   955 DIDDLELTLAKVEKEKHATENkvknltEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKSKVKLEQQVD 1034
Cdd:COG0542  412 ELDELERRLEQLEIEKEALKK------EQDEASFERLAELRDELAELEEELEALKARWEAEKELIEEIQELKEELEQRYG 485
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1035 DLEGSLEQEKKVRMDLERAKRKLEGDL------------------KLTQEsimdlENDKL-QLEEKLKKK 1085
Cdd:COG0542  486 KIPELEKELAELEEELAELAPLLREEVteediaevvsrwtgipvgKLLEG-----EREKLlNLEEELHER 550
CCDC73 pfam15818
Coiled-coil domain-containing protein 73 family; CCDC73 is a family of eukaryotic coiled-coil ...
767-1112 2.12e-03

Coiled-coil domain-containing protein 73 family; CCDC73 is a family of eukaryotic coiled-coil containing proteins. The function is not known. The alternative name is sarcoma antigen NY-SAR-79.


Pssm-ID: 464893 [Multi-domain]  Cd Length: 1048  Bit Score: 43.01  E-value: 2.12e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     767 FKAGLLGLLEEMR---------DERLSRIITRIQaqargqlmRIEFKKIVERRDALLVIQWNIRAFMGVKNWPWMKLYF- 836
Cdd:pfam15818    5 FKTSLLEALEELRmrreaetqyEEQIGKIIVETQ--------ELKWQKETLQNQKETLAKQHKEAMAVFKKQLQMKMCAl 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     837 ---KIKPLLKSAETEKEMANMKEEFgrvkDALEKSearrKELEEKMVSLLQEKndLQLQVQAEQD---NLNDAEeRCDQL 910
Cdd:pfam15818   77 eeeKGKYQLATEIKEKEIEGLKETL----KALQVS----KYSLQKKVSEMEQK--LQLHLLAKEDhhkQLNEIE-KYYAT 145
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     911 IKNKIQLeakVKEMTERLE----DEEEMNAELTAKKRKLEDECSELKKDIDDL--ELTLAKVE-KEKHATEN-------- 975
Cdd:pfam15818  146 ITGQFGL---VKENHGKLEqnvqEAIQLNKRLSALNKKQESEICSLKKELKKVtsDLIKSKVTcQYKMGEENinltikeq 222
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     976 KVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKSKVKLEQQVDDLEgslEQEKKVRMDLERAKR 1055
Cdd:pfam15818  223 KFQELQERLNMELELNKKINEEITHIQEEKQDIIISFQHMQQLLQQQTQANTEMEAELKALK---ENNQTLERDNELQRE 299
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 6754774    1056 KLegdlKLTQESIMDLENDKLQLEEKLKKKEFDISQQNSKIEDEQALALQLQKKLKE 1112
Cdd:pfam15818  300 KV----KENEEKFLNLQNEHEKALGTWKKHVEELNGEINEIKNELSSLKETHIKLQE 352
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
1270-1797 2.23e-03

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 43.02  E-value: 2.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1270 RSLNDFttqrakLQTENGELARQLEEKEALI--SQLTRGKLSYTQQMEDLKRQLEEEgkAKNALAHALQSSRHDCDLLRE 1347
Cdd:COG3096  214 RSLRDY------LLPENSGVRKAFQDMEAALreNRMTLEAIRVTQSDRDLFKHLITE--ATNYVAADYMRHANERRELSE 285
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1348 QyeeEMEAKAELQRVLSKANSEvaQWRTKYETDAIqrtEELEEAKKKLAQRLQDAEEAVEAVnakcssleKTKHRLQNEI 1427
Cdd:COG3096  286 R---ALELRRELFGARRQLAEE--QYRLVEMAREL---EELSARESDLEQDYQAASDHLNLV--------QTALRQQEKI 349
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1428 EDLMVDVErsnAAAAALDKKQrnfdKILAEWKQKYEESQSELESSQKEARSLSTELFKlknaYEESLEHLETfkrenKNL 1507
Cdd:COG3096  350 ERYQEDLE---ELTERLEEQE----EVVEEAAEQLAEAEARLEAAEEEVDSLKSQLAD----YQQALDVQQT-----RAI 413
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1508 QEEisdlteqlgeggKNVHELEKIRKQLEVEKLELQSALEEAEASLEHEEgkilraqlEFNQIKAEIERKLAekdeeMEQ 1587
Cdd:COG3096  414 QYQ------------QAVQALEKARALCGLPDLTPENAEDYLAAFRAKEQ--------QATEEVLELEQKLS-----VAD 468
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1588 AKRNHLRMVDSLQTSLDAETrSRNEALRVKKKMEGDLNEMEIQLSQANRIA---SEAQKHL---KNSQAHLKDTQLQLDD 1661
Cdd:COG3096  469 AARRQFEKAYELVCKIAGEV-ERSQAWQTARELLRRYRSQQALAQRLQQLRaqlAELEQRLrqqQNAERLLEEFCQRIGQ 547
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1662 AVHANDDLKENIAiverrnnLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLInqkkKMESDLTQLQT 1741
Cdd:COG3096  548 QLDAAEELEELLA-------ELEAQLEELEEQAAEAVEQRSELRQQLEQLRARIKELAARAPAWL----AAQDALERLRE 616
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 6754774  1742 EVEEAVQECRnaeekakkAITDAamMAEELKKEQDTSA---HLERMKKNMEQTIKDLQH 1797
Cdd:COG3096  617 QSGEALADSQ--------EVTAA--MQQLLEREREATVerdELAARKQALESQIERLSQ 665
PLN03188 PLN03188
kinesin-12 family protein; Provisional
865-1036 2.49e-03

kinesin-12 family protein; Provisional


Pssm-ID: 215621 [Multi-domain]  Cd Length: 1320  Bit Score: 43.00  E-value: 2.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    865 LEKSEARRKELEEKMVSLLQEkndLQLQVQAEQDNLN------DAEERCDQLIKNKIQLEAK-VKEMTERLEDEEEMNAE 937
Cdd:PLN03188 1049 LEQERLRWTEAESKWISLAEE---LRTELDASRALAEkqkhelDTEKRCAEELKEAMQMAMEgHARMLEQYADLEEKHIQ 1125
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    938 LTAKKRKLEDECSELKKD-------------IDDL--ELTLAKVEKEKHAT----ENK-----VKNLTEEMAGLDEIIAK 993
Cdd:PLN03188 1126 LLARHRRIQEGIDDVKKAaaragvrgaeskfINALaaEISALKVEREKERRylrdENKslqaqLRDTAEAVQAAGELLVR 1205
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 6754774    994 LTKEKKALQEAHQQALDDLQAEEDKVNTLTKSKVKLEQQVDDL 1036
Cdd:PLN03188 1206 LKEAEEALTVAQKRAMDAEQEAAEAYKQIDKLKRKHENEISTL 1248
PRK10929 PRK10929
putative mechanosensitive channel protein; Provisional
1564-1838 2.72e-03

putative mechanosensitive channel protein; Provisional


Pssm-ID: 236798 [Multi-domain]  Cd Length: 1109  Bit Score: 42.73  E-value: 2.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1564 QLEFNQIKAEIERklAEKDEEMEQAKrnhlrMVDSLQTSLDAetrsrnealrvkkkmegdLNEMEIQLSQANriasEAQK 1643
Cdd:PRK10929   22 APDEKQITQELEQ--AKAAKTPAQAE-----IVEALQSALNW------------------LEERKGSLERAK----QYQQ 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1644 HLKNSQAHLKDTQLQLDDAVHANDDLKENIAIVERRNNLLQAE---LEELRAVVEQTERSRKLAE-------------QE 1707
Cdd:PRK10929   73 VIDNFPKLSAELRQQLNNERDEPRSVPPNMSTDALEQEILQVSsqlLEKSRQAQQEQDRAREISDslsqlpqqqtearRQ 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1708 LIETSERVQLLHSQNTSLinqkkkMESDLTQLQteveeavqecrnAEEKAKKAITDaammaeELKkeqdtsahLERMKKN 1787
Cdd:PRK10929  153 LNEIERRLQTLGTPNTPL------AQAQLTALQ------------AESAALKALVD------ELE--------LAQLSAN 200
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 6754774   1788 MEQTIKDLQHRLdeaeqialkgGKKQLQKLEARVRELENELEAEQKRNAES 1838
Cdd:PRK10929  201 NRQELARLRSEL----------AKKRSQQLDAYLQALRNQLNSQRQREAER 241
HMMR_N pfam15905
Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of ...
1607-1861 2.90e-03

Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of eukaryotic hyaluronan-mediated motility receptor proteins. The protein is functionally associated with BRCA1 and thus predicted to be a common, low-penetrance breast cancer candidate.


Pssm-ID: 464932 [Multi-domain]  Cd Length: 329  Bit Score: 42.11  E-value: 2.90e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1607 TRSRNEALRVKKKMEGDLNEMEIQLSQANRIAS------EAQKHLKNSQAHLKDTQLQLDDAVHANDDLKENIAIVERRN 1680
Cdd:pfam15905   52 TARKVKSLELKKKSQKNLKESKDQKELEKEIRAlvqergEQDKRLQALEEELEKVEAKLNAAVREKTSLSASVASLEKQL 131
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1681 NLLQAELEELRAVVEQTERSRKLA--EQELIETSERvqlLHSQNTSLINQKKKMESDLTQLQTEVEEAVQECRNAEEKAK 1758
Cdd:pfam15905  132 LELTRVNELLKAKFSEDGTQKKMSslSMELMKLRNK---LEAKMKEVMAKQEGMEGKLQVTQKNLEHSKGKVAQLEEKLV 208
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1759 -----------------KAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIAlkggKKQLQKLEARV 1821
Cdd:pfam15905  209 stekekieeksetekllEYITELSCVSEQVEKYKLDIAQLEELLKEKNDEIESLKQSLEEKEQEL----SKQIKDLNEKC 284
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|.
gi 6754774    1822 RELENELEAEQKRNAESVKGMRKSERRIKE-LTYQTEEDKK 1861
Cdd:pfam15905  285 KLLESEKEELLREYEEKEQTLNAELEELKEkLTLEEQEHQK 325
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
898-1756 2.95e-03

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 42.63  E-value: 2.95e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   898 DNLNDAEERcDQLIKNKIQLEAKVKEMTERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATEnKV 977
Cdd:COG3096  272 DYMRHANER-RELSERALELRRELFGARRQLAEEQYRLVEMARELEELSARESDLEQDYQAASDHLNLVQTALRQQE-KI 349
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   978 KNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKL 1057
Cdd:COG3096  350 ERYQEDLEELTERLEEQEEVVEEAAEQLAEAEARLEAAEEEVDSLKSQLADYQQALDVQQTRAIQYQQAVQALEKARALC 429
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1058 EGDlKLTQESIMDLENDKLQLEEKLKKKEFDISQQNSKIED---EQALALQLQKKLKENQARIEELEEELEAERTARAKV 1134
Cdd:COG3096  430 GLP-DLTPENAEDYLAAFRAKEQQATEEVLELEQKLSVADAarrQFEKAYELVCKIAGEVERSQAWQTARELLRRYRSQQ 508
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1135 EKL--RSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKmRRDLEEatlqHEATAAALRKKHADSVAELGEQIDNL 1212
Cdd:COG3096  509 ALAqrLQQLRAQLAELEQRLRQQQNAERLLEEFCQRIGQQLDA-AEELEE----LLAELEAQLEELEEQAAEAVEQRSEL 583
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1213 QRvkqklekeksefklELDDVTsnmeQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKL-------QTE 1285
Cdd:COG3096  584 RQ--------------QLEQLR----ARIKELAARAPAWLAAQDALERLREQSGEALADSQEVTAAMQQLlerereaTVE 645
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1286 NGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEE---------------------GKAKNAL--------AHALQ 1336
Cdd:COG3096  646 RDELAARKQALESQIERLSQPGGAEDPRLLALAERLGGVllseiyddvtledapyfsalyGPARHAIvvpdlsavKEQLA 725
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1337 SsRHDC--DLLREQYEEE------MEAKAELQRVLSKanSEVAQWR-TKYETDAI-------QRTEELEEAKKKLAQRLQ 1400
Cdd:COG3096  726 G-LEDCpeDLYLIEGDPDsfddsvFDAEELEDAVVVK--LSDRQWRySRFPEVPLfgraareKRLEELRAERDELAEQYA 802
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1401 DAEEAVEavnaKCSSLEKTKHRLQNE------IEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESqselessqK 1474
Cdd:COG3096  803 KASFDVQ----KLQRLHQAFSQFVGGhlavafAPDPEAELAALRQRRSELERELAQHRAQEQQLRQQLDQL--------K 870
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1475 EARSLsteLFKLknayeesLEHLETFKRENknLQEEISDLTEQLGEGGKNVHELEKIRKQLEveKLE-LQSALEEAEASL 1553
Cdd:COG3096  871 EQLQL---LNKL-------LPQANLLADET--LADRLEELREELDAAQEAQAFIQQHGKALA--QLEpLVAVLQSDPEQF 936
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1554 EHEEGKILRAQLEFNQIKAEIErklaekdeEMEQ--AKRNHLRMVDSLQtsLDAETRSRNEALRVKkkmegdLNEMEIQL 1631
Cdd:COG3096  937 EQLQADYLQAKEQQRRLKQQIF--------ALSEvvQRRPHFSYEDAVG--LLGENSDLNEKLRAR------LEQAEEAR 1000
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1632 SQANRIASEAQKHLknSQAHlkDTQLQLDDAVHA-NDDLKEniaiverrnnlLQAELEEL--RAVVEQTERSRklaeqel 1708
Cdd:COG3096 1001 REAREQLRQAQAQY--SQYN--QVLASLKSSRDAkQQTLQE-----------LEQELEELgvQADAEAEERAR------- 1058
                        890       900       910       920
                 ....*....|....*....|....*....|....*....|....*...
gi 6754774  1709 ietsERVQLLHSQNTSLINQKKKMESDLTQLQTEVEEAVQECRNAEEK 1756
Cdd:COG3096 1059 ----IRRDELHEELSQNRSRRSQLEKQLTRCEAEMDSLQKRLRKAERD 1102
ycf1 CHL00204
Ycf1; Provisional
827-999 2.96e-03

Ycf1; Provisional


Pssm-ID: 214395 [Multi-domain]  Cd Length: 1832  Bit Score: 42.78  E-value: 2.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    827 KNWPWMKLYFKIKPLLKSAETEKE------MANMKEE--FGRVKDALEKSEARRKELEEKMVSLlQEKNDLQLQVQAEQD 898
Cdd:CHL00204  866 KPWHRSKLRSSHKDRMKKKKKKKNdfcfltVWGMETElpFGSPRKRPSFFEPIFKELKKKIRKF-KKKYFLVLKILKERT 944
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    899 N--LNDAEERCDQLIKNKIQLEAKVKEMTERledeeemNAELTAKKRKLeDECSELKKDIDDL-------ELTLAKVEKE 969
Cdd:CHL00204  945 KlfLKVSKETKKWIIKSFLFLKRIIKELSKR-------NPILLFGLREI-YELNETKKEKDSIisnqmihESSVQIRSME 1016
                         170       180       190
                  ....*....|....*....|....*....|...
gi 6754774    970 ---KHATENKVKNLTEEMAGLDEIIAKLTKEKK 999
Cdd:CHL00204 1017 wtnSSLTEKKIKDLTDRTKTIRNQIEKITKEKK 1049
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
837-1058 3.56e-03

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 42.33  E-value: 3.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    837 KIKPLLKSAETEKEMANMKEEFGRVKDALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKIQ 916
Cdd:PRK02224  497 RLERAEDLVEAEDRIERLEERREDLEELIAERRETIEEKRERAEELRERAAELEAEAEEKREAAAEAEEEAEEAREEVAE 576
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    917 LEAKVKEMTERLEDEEEMnAELTAKKRKLEDECSELKKDIDDleltLAKVEKEKHATenkvknLTEEMAGLDEIIAKLTK 996
Cdd:PRK02224  577 LNSKLAELKERIESLERI-RTLLAAIADAEDEIERLREKREA----LAELNDERRER------LAEKRERKRELEAEFDE 645
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6754774    997 EK-KALQEAHQQALDDLQAEEDKVNTLTKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLE 1058
Cdd:PRK02224  646 ARiEEAREDKERAEEYLEQVEEKLDELREERDDLQAEIGAVENELEELEELRERREALENRVE 708
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
1229-1448 3.89e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 41.74  E-value: 3.89e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1229 ELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTrgkl 1308
Cdd:COG3883   17 QIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGERA---- 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1309 sytqqmedlkRQLEEEGKAKNALAhALQSSRHDCDLLR--EQYEEEMEAKAELQRVLSKANSEVAQwrtkYETDAIQRTE 1386
Cdd:COG3883   93 ----------RALYRSGGSVSYLD-VLLGSESFSDFLDrlSALSKIADADADLLEELKADKAELEA----KKAELEAKLA 157
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6754774  1387 ELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQ 1448
Cdd:COG3883  158 ELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAA 219
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
1538-1911 3.99e-03

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 42.25  E-value: 3.99e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1538 EKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERK-LAEKDEEME-QAKRNHLRMVdslqtsldaetrsrNEALR 1615
Cdd:COG3096  279 ERRELSERALELRRELFGARRQLAEEQYRLVEMARELEELsARESDLEQDyQAASDHLNLV--------------QTALR 344
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1616 VKKKME---GDLNEMEIQLSQANRIASEAQKHLKNSQAHLKDTQLQLDDavhanddLKENIAIVERRNNLLQaeleelra 1692
Cdd:COG3096  345 QQEKIEryqEDLEELTERLEEQEEVVEEAAEQLAEAEARLEAAEEEVDS-------LKSQLADYQQALDVQQ-------- 409
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1693 vveqterSRKLAEQELIETSERVQ-LLHSQNTSLINqkkkMESDLTQLQTEVEEAVQECRNAEEK-----AKKAITDAAM 1766
Cdd:COG3096  410 -------TRAIQYQQAVQALEKARaLCGLPDLTPEN----AEDYLAAFRAKEQQATEEVLELEQKlsvadAARRQFEKAY 478
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1767 MA-EELKKEQDTSAHLERMKKNMEQTiKDLQHRLDeaeqialkggkkQLQKLEARVRELENELEAEQKrnaesvkgmrkS 1845
Cdd:COG3096  479 ELvCKIAGEVERSQAWQTARELLRRY-RSQQALAQ------------RLQQLRAQLAELEQRLRQQQN-----------A 534
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6754774  1846 ERRIKELTYQTEEDKKNLMRLQDLVDKLQLkvkaykrQAEEAEEQANTNLSKFRKVQHELDEAEER 1911
Cdd:COG3096  535 ERLLEEFCQRIGQQLDAAEELEELLAELEA-------QLEELEEQAAEAVEQRSELRQQLEQLRAR 593
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
1599-1924 4.09e-03

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 41.80  E-value: 4.09e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1599 LQTSLDAETRSRNEALR----VKKKMEGDLNEMEIQLSQANRIASEAQKHLKNSQAHLKDTQLQLDDAVHANDDLKENIA 1674
Cdd:pfam07888   32 LQNRLEECLQERAELLQaqeaANRQREKEKERYKRDREQWERQRRELESRVAELKEELRQSREKHEELEEKYKELSASSE 111
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1675 IVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQTEVEEAVQECRNae 1754
Cdd:pfam07888  112 ELSEEKDALLAQRAAHEARIRELEEDIKTLTQRVLERETELERMKERAKKAGAQRKEEEAERKQLQAKLQQTEEELRS-- 189
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1755 ekakkaitdaamMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQ--IALKGGKKQLQKLEARVRELENELEAeQ 1832
Cdd:pfam07888  190 ------------LSKEFQELRNSLAQRDTQVLQLQDTITTLTQKLTTAHRkeAENEALLEELRSLQERLNASERKVEG-L 256
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1833 KRNAESVKGMRksERRIKELTYQTEEDKKNLMRLQDLvdKLQLKVKAYKRQAEEAEEQANTNLSKFR--KVQHELDEAEE 1910
Cdd:pfam07888  257 GEELSSMAAQR--DRTQAELHQARLQAAQLTLQLADA--SLALREGRARWAQERETLQQSAEADKDRieKLSAELQRLEE 332
                          330
                   ....*....|....
gi 6754774    1911 RADIAESQVNKLRA 1924
Cdd:pfam07888  333 RLQEERMEREKLEV 346
PLN03229 PLN03229
acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Provisional
915-1222 4.24e-03

acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Provisional


Pssm-ID: 178768 [Multi-domain]  Cd Length: 762  Bit Score: 42.15  E-value: 4.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    915 IQLEAKVKEMTERLEDEEEMNAELTakKRKLEDECSELKKDIDdLELTLAKvekEKHATENKVKNLTEEMA--------- 985
Cdd:PLN03229  432 RELEGEVEKLKEQILKAKESSSKPS--ELALNEMIEKLKKEID-LEYTEAV---IAMGLQERLENLREEFSkansqdqlm 505
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    986 --GLDEIIAKLTKE-KKALQEAhqQALDDLQAEEDKVNTLTKSKVKLEQQVDDLEGSLEQEKKVR--MDLERAKRKLEGD 1060
Cdd:PLN03229  506 hpVLMEKIEKLKDEfNKRLSRA--PNYLSLKYKLDMLNEFSRAKALSEKKSKAEKLKAEINKKFKevMDRPEIKEKMEAL 583
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1061 LKLTQESIMDLENDklqLEEKLKKKefdISQQNSKIEDEQA-----LALQLQKKLKENQARIEELEEELEaertaRAKVE 1135
Cdd:PLN03229  584 KAEVASSGASSGDE---LDDDLKEK---VEKMKKEIELELAgvlksMGLEVIGVTKKNKDTAEQTPPPNL-----QEKIE 652
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1136 KLRSDLSRELEEISE-----------RLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATlqheaTAAALRKKHADSVAE 1204
Cdd:PLN03229  653 SLNEEINKKIERVIRssdlkskiellKLEVAKASKTPDVTEKEKIEALEQQIKQKIAEAL-----NSSELKEKFEELEAE 727
                         330
                  ....*....|....*...
gi 6754774   1205 LGEQIDNLQRVKQKLEKE 1222
Cdd:PLN03229  728 LAAARETAAESNGSLKND 745
Filament pfam00038
Intermediate filament protein;
1130-1363 4.35e-03

Intermediate filament protein;


Pssm-ID: 459643 [Multi-domain]  Cd Length: 313  Bit Score: 41.44  E-value: 4.35e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1130 ARAKVEKLRSDLSRELEEISERLEEaggatsvqiEMNKKR--EAEFQKMRRDLEEATLQH---EATA-------AALRKK 1197
Cdd:pfam00038   69 ERARLQLELDNLRLAAEDFRQKYED---------ELNLRTsaENDLVGLRKDLDEATLARvdlEAKIeslkeelAFLKKN 139
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1198 HADSVAELGEQIDNLQRVkqklekeksefkLELDDVTS-NMEQIIK-AKANLEKVSRTLEDQANE-YRVKLEEAQRSLND 1274
Cdd:pfam00038  140 HEEEVRELQAQVSDTQVN------------VEMDAARKlDLTSALAeIRAQYEEIAAKNREEAEEwYQSKLEELQQAAAR 207
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1275 FTTQRAKLQTENGELARQLEEKEALISQLTRgklsytqQMEDLKRQLEEegkAKNALAHALQSSRhdcDLLREQYEEEME 1354
Cdd:pfam00038  208 NGDALRSAKEEITELRRTIQSLEIELQSLKK-------QKASLERQLAE---TEERYELQLADYQ---ELISELEAELQE 274

                   ....*....
gi 6754774    1355 AKAELQRVL 1363
Cdd:pfam00038  275 TRQEMARQL 283
Tropomyosin pfam00261
Tropomyosin; Tropomyosin is an alpha-helical protein that forms a coiled-coil structure of 2 ...
1736-1922 4.52e-03

Tropomyosin; Tropomyosin is an alpha-helical protein that forms a coiled-coil structure of 2 parallel helices containing 2 sets of 7 alternating actin binding sites. The protein is best known for its role in regulating the interaction between actin and myosin in muscle contraction, but is also involved in the organization and dynamics of the cytoskeleton in non-muscle cells. There are multiple cell-specific isoforms, expressed by alternative promoters and alternative RNA processing of at least four genes. Muscle isoforms of tropomyosin are characterized by having 284 amino acid residues and a highly conserved N-terminal region, whereas non-muscle forms are generally smaller and are heterogeneous in their N-terminal region.


Pssm-ID: 459736 [Multi-domain]  Cd Length: 235  Bit Score: 40.78  E-value: 4.52e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1736 LTQLQTEVEEAVQECRNAEEK---AKKAITDAAMMAEELKKE-QDTSAHLERMKKNMEQTikdlQHRLDEAEQIA----- 1806
Cdd:pfam00261    3 MQQIKEELDEAEERLKEAMKKleeAEKRAEKAEAEVAALNRRiQLLEEELERTEERLAEA----LEKLEEAEKAAdeser 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1807 -LKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTE--EDK--KNLMRLQDLVDKLQL---KVK 1878
Cdd:pfam00261   79 gRKVLENRALKDEEKMEILEAQLKEAKEIAEEADRKYEEVARKLVVVEGDLEraEERaeLAESKIVELEEELKVvgnNLK 158
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....
gi 6754774    1879 AYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKL 1922
Cdd:pfam00261  159 SLEASEEKASEREDKYEEQIRFLTEKLKEAETRAEFAERSVQKL 202
Macoilin pfam09726
Macoilin family; The Macoilin proteins has an N-terminal portion that is composed of 5 ...
1247-1448 4.85e-03

Macoilin family; The Macoilin proteins has an N-terminal portion that is composed of 5 trasnmembrane helices, followed by a C-terminal coiled-coil region. Macoilin is a highly conserved protein present in eukaryotes. Macoilin appears to be found in the ER and be involved in the function of neurons.


Pssm-ID: 462859 [Multi-domain]  Cd Length: 670  Bit Score: 41.76  E-value: 4.85e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1247 LEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGK 1326
Cdd:pfam09726  400 LEQDIKKLKAELQASRQTEQELRSQISSLTSLERSLKSELGQLRQENDLLQTKLHNAVSAKQKDKQTVQQLEKRLKAEQE 479
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1327 AKNALAHALQSSRHdcdllREQYEEEMEAKAELQRVLSKANSevaqwrtkyeTDAI-QRTEELEEAKKKLAQRLQDAEEA 1405
Cdd:pfam09726  480 ARASAEKQLAEEKK-----RKKEEEATAARAVALAAASRGEC----------TESLkQRKRELESEIKKLTHDIKLKEEQ 544
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 6754774    1406 VEAVNAKCSSLEKTKHRlQNEIEDLMvdversNAAAAALDKKQ 1448
Cdd:pfam09726  545 IRELEIKVQELRKYKES-EKDTEVLM------SALSAMQDKNQ 580
Tropomyosin pfam00261
Tropomyosin; Tropomyosin is an alpha-helical protein that forms a coiled-coil structure of 2 ...
1684-1835 5.13e-03

Tropomyosin; Tropomyosin is an alpha-helical protein that forms a coiled-coil structure of 2 parallel helices containing 2 sets of 7 alternating actin binding sites. The protein is best known for its role in regulating the interaction between actin and myosin in muscle contraction, but is also involved in the organization and dynamics of the cytoskeleton in non-muscle cells. There are multiple cell-specific isoforms, expressed by alternative promoters and alternative RNA processing of at least four genes. Muscle isoforms of tropomyosin are characterized by having 284 amino acid residues and a highly conserved N-terminal region, whereas non-muscle forms are generally smaller and are heterogeneous in their N-terminal region.


Pssm-ID: 459736 [Multi-domain]  Cd Length: 235  Bit Score: 40.78  E-value: 5.13e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1684 QAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQTEVEEAVQECRNAEEKAKKAITD 1763
Cdd:pfam00261   63 LEKLEEAEKAADESERGRKVLENRALKDEEKMEILEAQLKEAKEIAEEADRKYEEVARKLVVVEGDLERAEERAELAESK 142
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6754774    1764 AAMMAEELKKEQDTSAHLE-------RMKKNMEQTIKDLQHRLDEAEQIALKGgKKQLQKLEARVRELENELEAEQKRN 1835
Cdd:pfam00261  143 IVELEEELKVVGNNLKSLEaseekasEREDKYEEQIRFLTEKLKEAETRAEFA-ERSVQKLEKEVDRLEDELEAEKEKY 220
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1774-1938 5.35e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 41.82  E-value: 5.35e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1774 EQDTSAHLERMKKNMEQtikdlqhrLDEAEQIALKGgKKQLQKLEaRVRELENELEAEQKRNAESVKGMRK-----SERR 1848
Cdd:COG4913  220 EPDTFEAADALVEHFDD--------LERAHEALEDA-REQIELLE-PIRELAERYAAARERLAELEYLRAAlrlwfAQRR 289
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1849 IKELTYQTEEDKKNLMRLQDLVDKLQLKVKAYKRQAEEAEEQANTN-LSKFRKVQHELDEAEERADIAESQVNKLRAKSR 1927
Cdd:COG4913  290 LELLEAELEELRAELARLEAELERLEARLDALREELDELEAQIRGNgGDRLEQLEREIERLERELEERERRRARLEALLA 369
                        170
                 ....*....|.
gi 6754774  1928 DIGAKKMHDEE 1938
Cdd:COG4913  370 ALGLPLPASAE 380
PRK12704 PRK12704
phosphodiesterase; Provisional
1530-1647 5.57e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 41.69  E-value: 5.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1530 KIRKQLEVEKLELQSALEEAEASLE-HEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRMVDSLQTSLDAETR 1608
Cdd:PRK12704   28 IAEAKIKEAEEEAKRILEEAKKEAEaIKKEALLEAKEEIHKLRNEFEKELRERRNELQKLEKRLLQKEENLDRKLELLEK 107
                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 6754774   1609 SRNEALRVKKKMEGDLNEMEIQLSQANRIASEAQKHLKN 1647
Cdd:PRK12704  108 REEELEKKEKELEQKQQELEKKEEELEELIEEQLQELER 146
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
1780-1901 5.98e-03

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 41.64  E-value: 5.98e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1780 HLERMKKNMEQTIKDLQHRLDEAEQIAlkggKKQLQKLEARVRELENELEaEQKRNAESVKGMRKSERrikeltyQTEED 1859
Cdd:pfam15921   75 HIERVLEEYSHQVKDLQRRLNESNELH----EKQKFYLRQSVIDLQTKLQ-EMQMERDAMADIRRRES-------QSQED 142
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 6754774    1860 KKNlmRLQDLVDKLQlkvkAYKRQAEEAEEQANTNLSKFRKV 1901
Cdd:pfam15921  143 LRN--QLQNTVHELE----AAKCLKEDMLEDSNTQIEQLRKM 178
Spc7 smart00787
Spc7 kinetochore protein; This domain is found in cell division proteins which are required ...
832-991 6.44e-03

Spc7 kinetochore protein; This domain is found in cell division proteins which are required for kinetochore-spindle association.


Pssm-ID: 197874 [Multi-domain]  Cd Length: 312  Bit Score: 40.77  E-value: 6.44e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774      832 MKLYFKIKPLL--KSAETEKEMANMKEEFGRVKDALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQ 909
Cdd:smart00787  139 MKLLEGLKEGLdeNLEGLKEDYKLLMKELELLNSIKPKLRDRKDALEEELRQLKQLEDELEDCDPTELDRAKEKLKKLLQ 218
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774      910 LIKNKIQleaKVKEMTERLEDEEEMNAELTAKKRKLEDECSELKK-----------DIDDLELTLAKVEKEKHATENKVK 978
Cdd:smart00787  219 EIMIKVK---KLEELEEELQELESKIEDLTNKKSELNTEIAEAEKkleqcrgftfkEIEKLKEQLKLLQSLTGWKITKLS 295
                           170
                    ....*....|...
gi 6754774      979 NLTEEMAGLDEII 991
Cdd:smart00787  296 GNTLSMTYDREIN 308
PLN03229 PLN03229
acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Provisional
848-1082 6.47e-03

acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Provisional


Pssm-ID: 178768 [Multi-domain]  Cd Length: 762  Bit Score: 41.38  E-value: 6.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    848 EKEMANMKEEFGRvkdALEKSEARRKELEEKMVSLLQEKN------------DLQLQVQAEQDNLNDAEERCDQLIKNKI 915
Cdd:PLN03229  485 QERLENLREEFSK---ANSQDQLMHPVLMEKIEKLKDEFNkrlsrapnylslKYKLDMLNEFSRAKALSEKKSKAEKLKA 561
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    916 QLEAKVKEMTERLEDEEEMNAeltakkRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMaGLDEIIAKlt 995
Cdd:PLN03229  562 EINKKFKEVMDRPEIKEKMEA------LKAEVASSGASSGDELDDDLKEKVEKMKKEIELELAGVLKSM-GLEVIGVT-- 632
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    996 keKKALQEAHQQALDDLQAEEDKVNTLTKSKVKLEQQVDDLEGSLEQEKkvrmdLERAKRKLEGDLKlTQESIMDLENdk 1075
Cdd:PLN03229  633 --KKNKDTAEQTPPPNLQEKIESLNEEINKKIERVIRSSDLKSKIELLK-----LEVAKASKTPDVT-EKEKIEALEQ-- 702

                  ....*..
gi 6754774   1076 lQLEEKL 1082
Cdd:PLN03229  703 -QIKQKI 708
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
1491-1630 6.50e-03

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 41.38  E-value: 6.50e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1491 EESLEHLeTFKRENKNLQEEISDLTEQLGEGGKNVHELEKIRKQ---LEVEKLELQSALEEAEASLEHEEGKILRAQLEf 1567
Cdd:COG2433  379 EEALEEL-IEKELPEEEPEAEREKEHEERELTEEEEEIRRLEEQverLEAEVEELEAELEEKDERIERLERELSEARSE- 456
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6754774  1568 nqikaeiERKLAEKDEEMEQAKrnhlRMVDSLQTSLDaETRSRNEALRVKKKMEGDLNEMEIQ 1630
Cdd:COG2433  457 -------ERREIRKDREISRLD----REIERLERELE-EERERIEELKRKLERLKELWKLEHS 507
PRK11281 PRK11281
mechanosensitive channel MscK;
1682-1838 6.94e-03

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 41.44  E-value: 6.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1682 LLQAELEELRAVVEQTERSRK----------LAEQELIETSERVQLLHSQNTSLINQKKKMESdLTQLQTEVEEAVQECR 1751
Cdd:PRK11281   60 LVQQDLEQTLALLDKIDRQKEeteqlkqqlaQAPAKLRQAQAELEALKDDNDEETRETLSTLS-LRQLESRLAQTLDQLQ 138
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1752 NAE-----------------EKAKKAITDAAMMAEE----LKKEQDTSAHL---ERMKKNMEQTIKDLQHRLdeaEQIAL 1807
Cdd:PRK11281  139 NAQndlaeynsqlvslqtqpERAQAALYANSQRLQQirnlLKGGKVGGKALrpsQRVLLQAEQALLNAQNDL---QRKSL 215
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 6754774   1808 KG-------GKKQLQKLEARVRELENELEAEQ-----KRNAES 1838
Cdd:PRK11281  216 EGntqlqdlLQKQRDYLTARIQRLEHQLQLLQeainsKRLTLS 258
Tektin pfam03148
Tektin family; Tektins are cytoskeletal proteins. They have been demonstrated in such cellular ...
1174-1349 7.03e-03

Tektin family; Tektins are cytoskeletal proteins. They have been demonstrated in such cellular sites as centrioles, basal bodies, and along ciliary and flagellar doublet microtubules. Tektins form unique protofilaments, organized as longitudinal polymers of tektin heterodimers with axial periodicity matching tubulin. Tektin polypeptides consist of several alpha-helical regions that are predicted to form coiled coils. Indeed, tektins share considerable structural similarities with intermediate filament proteins. Possible functional roles for tektins are: stabilization of tubulin protofilaments; attachment of A and B-tubules in ciliary/flagellar microtubule doublets and C-tubules in centrioles; binding of axonemal components.


Pssm-ID: 460827 [Multi-domain]  Cd Length: 383  Bit Score: 40.99  E-value: 7.03e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1174 QKMRRDLEEatlQHEATAAALRKKhadsvaelgeqIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLE---KV 1250
Cdd:pfam03148  232 EQTANDLRA---QADAVNFALRKR-----------IEETEDAKNKLEWQLKKTLQEIAELEKNIEALEKAIRDKEaplKL 297
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1251 SRT-LEDQAneYRVKLE----EAQRSLNDfttqraklqtengELARQLEEKEALISQLTRGKLSYtQQMEDLKRQLEEEG 1325
Cdd:pfam03148  298 AQTrLENRT--YRPNVElcrdEAQYGLVD-------------EVKELEETIEALKQKLAEAEASL-QALERTRLRLEEDI 361
                          170       180
                   ....*....|....*....|....
gi 6754774    1326 KAKNalaHALQSSRHDCDLLREQY 1349
Cdd:pfam03148  362 AVKA---NSLFIDREKCMGLRKRL 382
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
951-1907 7.05e-03

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 41.58  E-value: 7.05e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     951 ELKKDIDdleltlakvekEKHATENKVKNLTEEMAGLDEII--------AKLTKEKKALQEAHQQALDDLQAE-EDKVNT 1021
Cdd:TIGR01612  480 DIKKDID-----------ENSKQDNTVKLILMRMKDFKDIIdfmelykpDEVPSKNIIGFDIDQNIKAKLYKEiEAGLKE 548
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1022 LTKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKkkefDISQQNSKIEDeqa 1101
Cdd:TIGR01612  549 SYELAKNWKKLIHEIKKELEEENEDSIHLEKEIKDLFDKYLEIDDEIIYINKLKLELKEKIK----NISDKNEYIKK--- 621
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1102 lALQLQKKLKENQARIEELEEELEAERTARAK-VEKLRSDLSRELEEISE-RLEEAGGATSVQIEMN------------- 1166
Cdd:TIGR01612  622 -AIDLKKIIENNNAYIDELAKISPYQVPEHLKnKDKIYSTIKSELSKIYEdDIDALYNELSSIVKENaidntedkakldd 700
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1167 --KKREAEFQKMRrDLEEATLQ-HEATAAALRKKHADSVAEL-----GEQIDNLQRVKQKLEKEKSEFKLELDDVTSNME 1238
Cdd:TIGR01612  701 lkSKIDKEYDKIQ-NMETATVElHLSNIENKKNELLDIIVEIkkhihGEINKDLNKILEDFKNKEKELSNKINDYAKEKD 779
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1239 QIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLK 1318
Cdd:TIGR01612  780 ELNKYKSKISEIKNHYNDQINIDNIKDEDAKQNYDKSKEYIKTISIKEDEIFKIINEMKFMKDDFLNKVDKFINFENNCK 859
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1319 RQLEEEGKAKNALAHALQSSRHDCDLlrEQYEEEM-EAKAELQRVLSKANSEVAQWRTKYETDA-IQRTEELEEAKKKLA 1396
Cdd:TIGR01612  860 EKIDSEHEQFAELTNKIKAEISDDKL--NDYEKKFnDSKSLINEINKSIEEEYQNINTLKKVDEyIKICENTKESIEKFH 937
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1397 QRLQDAEEAVEA---VNAKCSSLEKT-KHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKIlaewkqKYEESQSELESS 1472
Cdd:TIGR01612  938 NKQNILKEILNKnidTIKESNLIEKSyKDKFDNTLIDKINELDKAFKDASLNDYEAKNNELI------KYFNDLKANLGK 1011
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1473 QKEArslstelfKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNV-HELEK-IRKQLEVEKLELqsaLEEAE 1550
Cdd:TIGR01612 1012 NKEN--------MLYHQFDEKEKATNDIEQKIEDANKNIPNIEIAIHTSIYNIiDEIEKeIGKNIELLNKEI---LEEAE 1080
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1551 ASLEHeegkilraqleFNQIKAEIERKLAE---KDEEMEQAKRNHlRMVDSLQTSLDAETRSRNEALRVKKKMEGDLNEM 1627
Cdd:TIGR01612 1081 INITN-----------FNEIKEKLKHYNFDdfgKEENIKYADEIN-KIKDDIKNLDQKIDHHIKALEEIKKKSENYIDEI 1148
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1628 EIQLSQANRIAseaqkhlknsqahlkdtqlqldDAVHANDDLKEniaiVERRnnllqaeleelravveqtersrklaEQE 1707
Cdd:TIGR01612 1149 KAQINDLEDVA----------------------DKAISNDDPEE----IEKK-------------------------IEN 1177
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1708 LIETSERVQLLHSQNTSLINQKKKMESDLTQLqteveeavQECRNAEEKAKKAItdAAMMAEELKKEQDTSAHlerMKKN 1787
Cdd:TIGR01612 1178 IVTKIDKKKNIYDEIKKLLNEIAEIEKDKTSL--------EEVKGINLSYGKNL--GKLFLEKIDEEKKKSEH---MIKA 1244
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1788 MEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAE----QKRNAESVKGMRKSERRI-------------- 1849
Cdd:TIGR01612 1245 MEAYIEDLDEIKEKSPEIENEMGIEMDIKAEMETFNISHDDDKDhhiiSKKHDENISDIREKSLKIiedfseesdindik 1324
                          970       980       990      1000      1010      1020      1030
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6754774    1850 KEL-TYQTEEDKKN------LMRLQDLVDKLQL--------KVKAYKRQAEEAEEQANTNLSKFRKVQHELDE 1907
Cdd:TIGR01612 1325 KELqKNLLDAQKHNsdinlyLNEIANIYNILKLnkikkiidEVKEYTKEIEENNKNIKDELDKSEKLIKKIKD 1397
CAGE1 pfam15066
Cancer-associated gene protein 1 family; CAGE-1 is a family of proteins overexpressed in ...
1035-1249 7.07e-03

Cancer-associated gene protein 1 family; CAGE-1 is a family of proteins overexpressed in tumour tissues compared with surrounding tissues. CAGE-1 gene showed testis-specific expression among normal tissues and displayed wide expression in a variety of cancer cell lines and cancer tissues. CAGE-1 is predominantly expressed during post-meiotic stages. It localizes to the acrosomal matrix and acrosomal granule showing it to be a component of the acrosome of mammalian spermatids and spermatozoa.


Pssm-ID: 464481  Cd Length: 528  Bit Score: 41.36  E-value: 7.07e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1035 DLEGSLE--QEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDISQQN--------------SKIED 1098
Cdd:pfam15066  299 DTEQSFEslQPLEEDMALNEVLQKLKHTNRKQQMQIQDLQCSNLYLEKKVKELQMKITKQQvfvdiinklkenveELIED 378
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1099 EQALALQ----------LQKKLKENQARIEELEEELEaerTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNK- 1167
Cdd:pfam15066  379 KYNVILEkndinktlqnLQEILANTQKHLQESRKEKE---TLQLELKKIKVNYVHLQERYITEMQQKNKSVSQCLEMDKt 455
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1168 --KREAE---FQKMRRDLEEATlqheATAAALRKKHADSvaeLGEQIDNLQRVKQKLEKEksefklelddvtsNMEQIIK 1242
Cdd:pfam15066  456 lsKKEEEverLQQLKGELEKAT----TSALDLLKREKET---REQEFLSLQEEFQKHEKE-------------NLEERQK 515

                   ....*..
gi 6754774    1243 AKANLEK 1249
Cdd:pfam15066  516 LKSRLEK 522
PRK12704 PRK12704
phosphodiesterase; Provisional
1751-1916 7.08e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 41.30  E-value: 7.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1751 RNAEEKAKKAITDAAMMAEELKKEqdtsahLERMKKNMEQTIKDLQHRLdeaeqialkggkkqLQKLEARVRELENELEA 1830
Cdd:PRK12704   27 KIAEAKIKEAEEEAKRILEEAKKE------AEAIKKEALLEAKEEIHKL--------------RNEFEKELRERRNELQK 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1831 EQKRNAESVKGMRKSERRIKELTYQTEEDKKNLMRLQDLVDKLQLKVKAYKRQAEEAEEQAnTNLSKFRKVQHELDEAEE 1910
Cdd:PRK12704   87 LEKRLLQKEENLDRKLELLEKREEELEKKEKELEQKQQELEKKEEELEELIEEQLQELERI-SGLTAEEAKEILLEKVEE 165

                  ....*...
gi 6754774   1911 --RADIAE 1916
Cdd:PRK12704  166 eaRHEAAV 173
Tropomyosin pfam00261
Tropomyosin; Tropomyosin is an alpha-helical protein that forms a coiled-coil structure of 2 ...
849-1045 7.10e-03

Tropomyosin; Tropomyosin is an alpha-helical protein that forms a coiled-coil structure of 2 parallel helices containing 2 sets of 7 alternating actin binding sites. The protein is best known for its role in regulating the interaction between actin and myosin in muscle contraction, but is also involved in the organization and dynamics of the cytoskeleton in non-muscle cells. There are multiple cell-specific isoforms, expressed by alternative promoters and alternative RNA processing of at least four genes. Muscle isoforms of tropomyosin are characterized by having 284 amino acid residues and a highly conserved N-terminal region, whereas non-muscle forms are generally smaller and are heterogeneous in their N-terminal region.


Pssm-ID: 459736 [Multi-domain]  Cd Length: 235  Bit Score: 40.40  E-value: 7.10e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     849 KEMANMKEEFGRVKDALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKIQLEAKVKEM---- 924
Cdd:pfam00261    1 KKMQQIKEELDEAEERLKEAMKKLEEAEKRAEKAEAEVAALNRRIQLLEEELERTEERLAEALEKLEEAEKAADESergr 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774     925 ----TERLEDEEEMN---AELTAKKRKLED---ECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKL 994
Cdd:pfam00261   81 kvleNRALKDEEKMEileAQLKEAKEIAEEadrKYEEVARKLVVVEGDLERAEERAELAESKIVELEEELKVVGNNLKSL 160
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 6754774     995 -TKEKKALQ------EAHQQALDDLQAEEDKVNTLTKSKVKLEQQVDDLEGSLEQEKK 1045
Cdd:pfam00261  161 eASEEKASEredkyeEQIRFLTEKLKEAETRAEFAERSVQKLEKEVDRLEDELEAEKE 218
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
1676-1921 7.25e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 41.26  E-value: 7.25e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1676 VERRNNL------LQAELEELRAVVEQTERSRKLAEQEL--IETSERVQLLHSQNTSLINQKKKMESDLTQLQTEVEEAV 1747
Cdd:pfam17380  312 VERRRKLeeaekaRQAEMDRQAAIYAEQERMAMERERELerIRQEERKRELERIRQEEIAMEISRMRELERLQMERQQKN 391
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1748 QECRNAEEKAKKAitdaaMMAEElkkeqdtsahlERMKKNMEQTIKDLQHRLDEAEqialkGGKKQLQKLEA-RVRELEN 1826
Cdd:pfam17380  392 ERVRQELEAARKV-----KILEE-----------ERQRKIQQQKVEMEQIRAEQEE-----ARQREVRRLEEeRAREMER 450
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1827 ELEAEQKRNaESVKGMRKSERRIKELTYQTEEDKKNLMRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELD 1906
Cdd:pfam17380  451 VRLEEQERQ-QQVERLRQQEEERKRKKLELEKEKRDRKRAEEQRRKILEKELEERKQAMIEEERKRKLLEKEMEERQKAI 529
                          250
                   ....*....|....*
gi 6754774    1907 EAEERADIAESQVNK 1921
Cdd:pfam17380  530 YEEERRREAEEERRK 544
growth_prot_Scy NF041483
polarized growth protein Scy;
972-1937 7.30e-03

polarized growth protein Scy;


Pssm-ID: 469371 [Multi-domain]  Cd Length: 1293  Bit Score: 41.35  E-value: 7.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    972 ATENKVKNLTEEMAGLdeiIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKSKVKLEQQvddlEGSLEQEKKVRMDLE 1051
Cdd:NF041483  302 ANEQRTRTAKEEIARL---VGEATKEAEALKAEAEQALADARAEAEKLVAEAAEKARTVAA----EDTAAQLAKAARTAE 374
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1052 RAKRKLEGDLKLTQESIMDlENDKLQLE-----EKLKKKEFDISQQnskiedeqaLALQLQKKLKENQARieeLEEELEA 1126
Cdd:NF041483  375 EVLTKASEDAKATTRAAAE-EAERIRREaeaeaDRLRGEAADQAEQ---------LKGAAKDDTKEYRAK---TVELQEE 441
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1127 ERTARAKVEKLRSDLSRELEEIseRLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELG 1206
Cdd:NF041483  442 ARRLRGEAEQLRAEAVAEGERI--RGEARREAVQQIEEAARTAEELLTKAKADADELRSTATAESERVRTEAIERATTLR 519
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1207 EQIDN-LQRVKQKLEKEKSEFKLELDDVTSNMEQiiKAKANLEKVSRTLEDQA-----------NEYRVKLEEAQRSLND 1274
Cdd:NF041483  520 RQAEEtLERTRAEAERLRAEAEEQAEEVRAAAER--AARELREETERAIAARQaeaaeeltrlhTEAEERLTAAEEALAD 597
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1275 FTTQRAKLQTENGelarqlEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHAlQSSRHDCDLLREQYEEEME 1354
Cdd:NF041483  598 ARAEAERIRREAA------EETERLRTEAAERIRTLQAQAEQEAERLRTEAAADASAARA-EGENVAVRLRSEAAAEAER 670
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1355 AKAELQRVLSKANSEVAQWRTKYETDAiqrTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSlEKTKHRLQNEiedlmvdv 1434
Cdd:NF041483  671 LKSEAQESADRVRAEAAAAAERVGTEA---AEALAAAQEEAARRRREAEETLGSARAEADQ-ERERAREQSE-------- 738
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1435 ersnaaaaaldkkqrnfdKILAEWKQKYEESQSELESSQKEARSLSTELfkLKNAYEESLEHLETFKRENKNLQEEISDL 1514
Cdd:NF041483  739 ------------------ELLASARKRVEEAQAEAQRLVEEADRRATEL--VSAAEQTAQQVRDSVAGLQEQAEEEIAGL 798
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1515 TEQLGeggknvHELEKIRKQLEVEKLELQS-ALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEE--------M 1585
Cdd:NF041483  799 RSAAE------HAAERTRTEAQEEADRVRSdAYAERERASEDANRLRREAQEETEAAKALAERTVSEAIAEaerlrsdaS 872
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1586 EQAKRNHLRMVDSLQTSLDAETRSRNEALRVKKKMEGDlnemeiQLSQANRIASEAQKHLKNSQAHLKDTQLQLDDAVHA 1665
Cdd:NF041483  873 EYAQRVRTEASDTLASAEQDAARTRADAREDANRIRSD------AAAQADRLIGEATSEAERLTAEARAEAERLRDEARA 946
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1666 NDDLK--ENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTqLQTEV 1743
Cdd:NF041483  947 EAERVraDAAAQAEQLIAEATGEAERLRAEAAETVGSAQQHAERIRTEAERVKAEAAAEAERLRTEAREEADRT-LDEAR 1025
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1744 EEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAhLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEaRVRE 1823
Cdd:NF041483 1026 KDANKRRSEAAEQADTLITEAAAEADQLTAKAQEEA-LRTTTEAEAQADTMVGAARKEAERIVAEATVEGNSLVE-KART 1103
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1824 LENELEAEQKRNAESVKGmRKSERR------IKELTYQTEEDKKNLMRLQ-DLVDKLqlkVKAYKRQAEEAEEQ------ 1890
Cdd:NF041483 1104 DADELLVGARRDATAIRE-RAEELRdritgeIEELHERARRESAEQMKSAgERCDAL---VKAAEEQLAEAEAKakelvs 1179
                         970       980       990      1000      1010
                  ....*....|....*....|....*....|....*....|....*....|...
gi 6754774   1891 -ANTNLSKFR-----KVQHELDEAEERADIAESQVNKLRAKSrDIGAKKMHDE 1937
Cdd:NF041483 1180 dANSEASKVRiaavkKAEGLLKEAEQKKAELVREAEKIKAEA-EAEAKRTVEE 1231
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
1773-1925 7.32e-03

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 41.26  E-value: 7.32e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1773 KEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGK------KQLQKLEARVRELENELEAEQKRNAESVKGMRKSE 1846
Cdd:pfam05557    3 ELIESKARLSQLQNEKKQMELEHKRARIELEKKASALKRqldresDRNQELQKRIRLLEKREAEAEEALREQAELNRLKK 82
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6754774    1847 RRIKELTYQTEEDKKNLMRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAK 1925
Cdd:pfam05557   83 KYLEALNKKLNEKESQLADAREVISCLKNELSELRRQIQRAELELQSTNSELEELQERLDLLKAKASEAEQLRQNLEKQ 161
Spc7 smart00787
Spc7 kinetochore protein; This domain is found in cell division proteins which are required ...
909-1114 7.60e-03

Spc7 kinetochore protein; This domain is found in cell division proteins which are required for kinetochore-spindle association.


Pssm-ID: 197874 [Multi-domain]  Cd Length: 312  Bit Score: 40.77  E-value: 7.60e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774      909 QLIKNKIQLeakVKEMterledeeemnAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKhatenkvKNLTEEMAGLD 988
Cdd:smart00787  113 LLMDKQFQL---VKTF-----------ARLEAKKMWYEWRMKLLEGLKEGLDENLEGLKEDY-------KLLMKELELLN 171
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774      989 EIIAKLTKEKKALQEAHQQalddlqaeedkvntltkskvkLEQQVDDLEgsleqeKKVRMDLERAKRKLegdlKLTQESI 1068
Cdd:smart00787  172 SIKPKLRDRKDALEEELRQ---------------------LKQLEDELE------DCDPTELDRAKEKL----KKLLQEI 220
                           170       180       190       200
                    ....*....|....*....|....*....|....*....|....*.
gi 6754774     1069 MDLENDKLQLEEKLKKKEFDISQQNSKIEDEQALALQLQKKLKENQ 1114
Cdd:smart00787  221 MIKVKKLEELEEELQELESKIEDLTNKKSELNTEIAEAEKKLEQCR 266
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
1698-1912 7.70e-03

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


Pssm-ID: 464815 [Multi-domain]  Cd Length: 522  Bit Score: 41.09  E-value: 7.70e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1698 ERSRKLAEQELIETSERVQllhSQNTSLINQKKKMEsdltqlQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDT 1777
Cdd:pfam15709  314 ERSEEDPSKALLEKREQEK---ASRDRLRAERAEMR------RLEVERKRREQEEQRRLQQEQLERAEKMREELELEQQR 384
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1778 SAHLERMKKnmeQTIKDLQHRLDEAEqialKGGKKQLQKLEARVRELENE-----LEAEQKRNAESVKGMRKSERRIKEL 1852
Cdd:pfam15709  385 RFEEIRLRK---QRLEEERQRQEEEE----RKQRLQLQAAQERARQQQEEfrrklQELQRKKQQEEAERAEAEKQRQKEL 457
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6754774    1853 TYQTEEDKKNLMRL--QDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHE-LDEAEERA 1912
Cdd:pfam15709  458 EMQLAEEQKRLMEMaeEERLEYQRQKQEAEEKARLEAEERRQKEEEAARLALEEaMKQAQEQA 520
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
918-1066 7.70e-03

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 41.35  E-value: 7.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    918 EAKvKEMTERLEDEEEMNAELTAKKRKLEDEcselkkdiddleltLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLtke 997
Cdd:PRK00409  506 EAK-KLIGEDKEKLNELIASLEELERELEQK--------------AEEAEALLKEAEKLKEELEEKKEKLQEEEDKL--- 567
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6754774    998 KKALQEAHQQALDDLQAEEDKVntltkskVKLEQQVDDLEGSLEQEKkvrmDLERAKRKLEGDLKLTQE 1066
Cdd:PRK00409  568 LEEAEKEAQQAIKEAKKEADEI-------IKELRQLQKGGYASVKAH----ELIEARKRLNKANEKKEK 625
PRK10361 PRK10361
DNA recombination protein RmuC; Provisional
1764-1928 8.35e-03

DNA recombination protein RmuC; Provisional


Pssm-ID: 182409 [Multi-domain]  Cd Length: 475  Bit Score: 40.74  E-value: 8.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1764 AAMMAEELKKEQDTSAHLERMKKNMEQTikdlQHRLDEAEQI--ALKGGKKQLQKLEARVRELENELEAEQKRNAESVKG 1841
Cdd:PRK10361   28 AQQKAEQLAEREEMVAELSAAKQQITQS----EHWRAECELLnnEVRSLQSINTSLEADLREVTTRMEAAQQHADDKIRQ 103
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   1842 MRKSERRIKE----LTYQTEE------DKKNLMRLQDLVDKLQLKVKAYKRQAEEA---EEQANTNLSkfrkvqHELDEA 1908
Cdd:PRK10361  104 MINSEQRLSEqfenLANRIFEhsnrrvDEQNRQSLNSLLSPLREQLDGFRRQVQDSfgkEAQERHTLA------HEIRNL 177
                         170       180
                  ....*....|....*....|.
gi 6754774   1909 EE-RADIAESQVNKLRAKSRD 1928
Cdd:PRK10361  178 QQlNAQMAQEAINLTRALKGD 198
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
846-1154 8.41e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 40.66  E-value: 8.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   846 ETEKEMANMKEEFGRVKDALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKIQLEAKVKEMT 925
Cdd:COG4372   56 QAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEEAEELQEELEELQKERQDLEQQRKQLE 135
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774   926 ERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLE-----LTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKA 1000
Cdd:COG4372  136 AQIAELQSEIAEREEELKELEEQLESLQEELAALEqelqaLSEAEAEQALDELLKEANRNAEKEEELAEAEKLIESLPRE 215
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774  1001 LQEAHQQALDDLQAEEDKVNTLTKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEE 1080
Cdd:COG4372  216 LAEELLEAKDSLEAKLGLALSALLDALELEEDKEELLEEVILKEIEELELAILVEKDTEEEELEIAALELEALEEAALEL 295
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6754774  1081 KLKKKEFDISQQNSKIEDEQALALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEE 1154
Cdd:COG4372  296 KLLALLLNLAALSLIGALEDALLAALLELAKKLELALAILLAELADLLQLLLVGLLDNDVLELLSKGAEAGVAD 369
CusB_dom_1 pfam00529
Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli ...
1524-1708 8.48e-03

Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli can be divided into four different domains, the first three domains of the protein are mostly beta-strands and the fourth forms an all alpha-helical domain. This entry represents the first beta-domain (domain 1) of CusB and it is formed by the N and C-terminal ends of the polypeptide (residues 89-102 and 324-385). CusB is part of the copper-transporting efflux system CusCFBA. This domain can also be found in other membrane-fusion proteins, such as HlyD, MdtN, MdtE and AaeA. HlyD is a component of the prototypical alpha-haemolysin (HlyA) bacterial type I secretion system, along with the other components HlyB and TolC. HlyD is anchored in the cytoplasmic membrane by a single transmembrane domain and has a large periplasmic domain within the carboxy-terminal 100 amino acids, HlyB and HlyD form a stable complex that binds the recombinant protein bearing a C-terminal HlyA signal sequence and ATP in the cytoplasm. HlyD, HlyB and TolC combine to form the three-component ABC transporter complex that forms a trans-membrane channel or pore through which HlyA can be transferred directly to the extracellular medium. Cutinase has been shown to be transported effectively through this pore.


Pssm-ID: 425733 [Multi-domain]  Cd Length: 322  Bit Score: 40.48  E-value: 8.48e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1524 NVHELEKIRKQ---LEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKdeemeqakrnhlRMVDSLQ 1600
Cdd:pfam00529   35 LVKEGDRVKAGdvlFQLDPTDYQAALDSAEAQLAKAQAQVARLQAELDRLQALESELAISR------------QDYDGAT 102
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754774    1601 TSLDAETRSRNEALRVKKKMEGDLNEMEIQLSQANRIAS---EAQKHLKNSQAHLKDTQLQLdDAVHANDDLKENIAIVE 1677
Cdd:pfam00529  103 AQLRAAQAAVKAAQAQLAQAQIDLARRRVLAPIGGISREslvTAGALVAQAQANLLATVAQL-DQIYVQITQSAAENQAE 181
                          170       180       190
                   ....*....|....*....|....*....|.
gi 6754774    1678 RRNNLLQAELEelravVEQTERSRKLAEQEL 1708
Cdd:pfam00529  182 VRSELSGAQLQ-----IAEAEAELKLAKLDL 207
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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