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Conserved domains on  [gi|78126169|ref|NP_035505|]
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lactosylceramide alpha-2,3-sialyltransferase isoform b [Mus musculus]

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 10466376)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.-.-
Gene Ontology:  GO:0006486|GO:0008373
PubMed:  9334165

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 164-373 7.70e-148

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


:

Pssm-ID: 467711  Cd Length: 211  Bit Score: 416.83  E-value: 7.70e-148
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169 164 CKRCVVVGNGGILHGLELGHALNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPLSDVEYYANDLFVTVLFKSVDF 243
Cdd:cd23983   2 CRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMTYPEGAPKSEQEYDPTSLFVAVLFKSVDF 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169 244 KWLQAMVKNESLPFWVRLFFWKQVAEKVPLQPKHFRILNPVIIKETAFDILQYSEPQSRFWGHDKNIPTIGVIAVVLATH 323
Cdd:cd23983  82 AWLKAMVKKEPLSFWSRLFFWKEVADSIPLKPSQFRILNPLIIKETALDILQYPEPQSRLWGWDKNVPTLGVTAVVLATH 161

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 78126169 324 LCDEVSLAGFGYDLSQPRTPLHYFDSQCMGAMHWQVMHNVTTETKFLLKL 373
Cdd:cd23983 162 LCDEVSLAGFGYDLSQPHAPLHYYDSVCMAAMNTQTMHNVTKETKFLKKL 211
 
Name Accession Description Interval E-value
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 164-373 7.70e-148

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 416.83  E-value: 7.70e-148
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169 164 CKRCVVVGNGGILHGLELGHALNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPLSDVEYYANDLFVTVLFKSVDF 243
Cdd:cd23983   2 CRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMTYPEGAPKSEQEYDPTSLFVAVLFKSVDF 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169 244 KWLQAMVKNESLPFWVRLFFWKQVAEKVPLQPKHFRILNPVIIKETAFDILQYSEPQSRFWGHDKNIPTIGVIAVVLATH 323
Cdd:cd23983  82 AWLKAMVKKEPLSFWSRLFFWKEVADSIPLKPSQFRILNPLIIKETALDILQYPEPQSRLWGWDKNVPTLGVTAVVLATH 161

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 78126169 324 LCDEVSLAGFGYDLSQPRTPLHYFDSQCMGAMHWQVMHNVTTETKFLLKL 373
Cdd:cd23983 162 LCDEVSLAGFGYDLSQPHAPLHYYDSVCMAAMNTQTMHNVTKETKFLKKL 211
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 129-378 1.34e-90

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 273.33  E-value: 1.34e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169   129 KYDPPFgfrkfsSKVQSLLDMLPEhdfPEHLRAKACKRCVVVGNGGILHGLELGHALNQFDVVIRLNSAPVEGYSEHVGN 208
Cdd:pfam00777  17 EWWLPF------TVTEELLELLPK---VSPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGS 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169   209 KTTIRMTYPEGAPLSDV-------EYYANDLFVTVLFKSVDFKWLQAMVKNESLPF-WVRLFFWKQVaeKVPLQPKHFRI 280
Cdd:pfam00777  88 KTTLRTMNPESAIDSKYgnlgfshPRDPFVEFVLVPFKGRDLLWLPAFLTKGNVSRsLRVLYTLKEV--KIPVDPDKVLF 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169   281 LNPVIIKETAFDILQYSEPQSRfwghdknIPTIGVIAVVLATHLCDEVSLAGFGYDLSQPRTPLHYFDSQCMGAMHWQVM 360
Cdd:pfam00777 166 LHPDFLRYVANFWLRSHGLKGR-------RPSTGLLMLSLALHLCDEVSLYGFGPFLDSRGNSHHYYDNVLMKKGGFYGV 238

                         250
                  ....*....|....*...
gi 78126169   361 HNVTTETKFLLKLLKEGV 378
Cdd:pfam00777 239 HDMPFEFKLLQKLHKEGV 256
 
Name Accession Description Interval E-value
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 164-373 7.70e-148

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 416.83  E-value: 7.70e-148
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169 164 CKRCVVVGNGGILHGLELGHALNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPLSDVEYYANDLFVTVLFKSVDF 243
Cdd:cd23983   2 CRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMTYPEGAPKSEQEYDPTSLFVAVLFKSVDF 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169 244 KWLQAMVKNESLPFWVRLFFWKQVAEKVPLQPKHFRILNPVIIKETAFDILQYSEPQSRFWGHDKNIPTIGVIAVVLATH 323
Cdd:cd23983  82 AWLKAMVKKEPLSFWSRLFFWKEVADSIPLKPSQFRILNPLIIKETALDILQYPEPQSRLWGWDKNVPTLGVTAVVLATH 161

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 78126169 324 LCDEVSLAGFGYDLSQPRTPLHYFDSQCMGAMHWQVMHNVTTETKFLLKL 373
Cdd:cd23983 162 LCDEVSLAGFGYDLSQPHAPLHYYDSVCMAAMNTQTMHNVTKETKFLKKL 211
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 164-373 1.07e-115

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 335.03  E-value: 1.07e-115
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169 164 CKRCVVVGNGGILHGLELGHALNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPLSDVEYYANDLFVTVLFKSVDF 243
Cdd:cd23967   2 CRRCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKGYEKDVGSKTTFRMFYPESAFRDPEEYDSDWLLVLVPFKSMDL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169 244 KWLQAMVKNESLPFWVrlFFWKQVAEKVPLQPKHFRILNPVIIKETAFDILQYSEPQSRfwghDKNIPTIGVIAVVLATH 323
Cdd:cd23967  82 LWLQAVIKGKKPNGKG--GFWKKIATSVPKPPKKIRILNPYILQEAAFDLIGLPMNGKQ----GKNVPTTGIIAIVMALH 155

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 78126169 324 LCDEVSLAGFGYDLSQPRTPLHYFDSQCMGAMHWQVMHNVTTETKFLLKL 373
Cdd:cd23967 156 YCDEVDIAGFGYDPSDPNAPLHYYDSLTMKAIKRSWTHNVTKEKKYLKKL 205
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 129-378 1.34e-90

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 273.33  E-value: 1.34e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169   129 KYDPPFgfrkfsSKVQSLLDMLPEhdfPEHLRAKACKRCVVVGNGGILHGLELGHALNQFDVVIRLNSAPVEGYSEHVGN 208
Cdd:pfam00777  17 EWWLPF------TVTEELLELLPK---VSPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGS 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169   209 KTTIRMTYPEGAPLSDV-------EYYANDLFVTVLFKSVDFKWLQAMVKNESLPF-WVRLFFWKQVaeKVPLQPKHFRI 280
Cdd:pfam00777  88 KTTLRTMNPESAIDSKYgnlgfshPRDPFVEFVLVPFKGRDLLWLPAFLTKGNVSRsLRVLYTLKEV--KIPVDPDKVLF 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169   281 LNPVIIKETAFDILQYSEPQSRfwghdknIPTIGVIAVVLATHLCDEVSLAGFGYDLSQPRTPLHYFDSQCMGAMHWQVM 360
Cdd:pfam00777 166 LHPDFLRYVANFWLRSHGLKGR-------RPSTGLLMLSLALHLCDEVSLYGFGPFLDSRGNSHHYYDNVLMKKGGFYGV 238

                         250
                  ....*....|....*...
gi 78126169   361 HNVTTETKFLLKLLKEGV 378
Cdd:pfam00777 239 HDMPFEFKLLQKLHKEGV 256
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 163-373 2.07e-70

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 219.79  E-value: 2.07e-70
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169 163 ACKRCVVVGNGGILHGLELGHALNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPLSDVEYYANDLFVTVLFKSVD 242
Cdd:cd23981   1 SCRRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRITYPEGAIQKPEQYEKDSLFVLAGFKWQD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169 243 FKWLQAMVKNESlpfwVRLF--FWKQVAEKVPLQPKHFRILNPVIIKETAFDILQYsePQSRFWGHDKNIPTIGVIAVVL 320
Cdd:cd23981  81 FKWLKYIVYKEK----VSASdgFWKSVATRVPREPHEIRILNPYFIQEAAFSFIGL--PFNNGLMGRGNIPTLGSVAITM 154

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 78126169 321 ATHLCDEVSLAGFGYDLSQPRTPLHYFDSQCMGAMHWQVMHNVTTETKFLLKL 373
Cdd:cd23981 155 ALHNCDEVAVAGFGYDMNTPNAPLHYYETIKMSAIKESWTHNIQREKEFLRKL 207
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 164-373 3.92e-66

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 208.75  E-value: 3.92e-66
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169 164 CKRCVVVGNGGILHGLELGHALNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPLSDVEYYAND-LFVTVLFKSVD 242
Cdd:cd23982   2 CRRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLFYPESAQFDPGIENDPDtLLVLVPFKPLD 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169 243 FKWLQAMVKNESLpfwVRLFFWKQVAEKVPLQPKHFRILNPVIIKETAFDILQYSEPQSrfwghDKNIPTIGVIAVVLAT 322
Cdd:cd23982  82 FYWLYEILSNEKR---VRKGFWKQPPRIWDANPKQIRILNPYYTYVAATKLLQVPGQRK-----KKQKPTTGLLAITLAL 153

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 78126169 323 HLCDEVSLAGFGY-DLSQPRTPLHYFDSQCMGAMHwQVMHNVTTETKFLLKL 373
Cdd:cd23982 154 HLCDEVHIAGFGYpDNGNSNQPIHYYNQITLKSMA-NSGHNLNAEAQAIQRL 204
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 163-373 3.39e-60

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 193.42  E-value: 3.39e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169 163 ACKRCVVVGNGGILHGLELGHALNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPLSDVEYYANDLFVTVLFKSVD 242
Cdd:cd23984   1 SCKKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFRLCYPESIFSDPSHYDPNTTVVLIPFKPHD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169 243 FKWLQAMVKNESlpfwVRLF-FWKQVAEKVPLQPKHFRILNPVIIKETAFDILQYSEpqsRFWGHDKNI-PTIGVIAVVL 320
Cdd:cd23984  81 LRWLLDLLMGKK----VSAKgFWKKPALNLIYKPNQIRILNPFILRIAAYELLHFPK---RFPKEKKPKhPTTGIIAITL 153

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 78126169 321 ATHLCDEVSLAGFGYDLSQPRTPLHYFDSQCMGAMHWQVMHNVTTETKFLLKL 373
Cdd:cd23984 154 ALHICNEVHIAGFKYDFSNLNSTLHYYGNETMSVMTKNEYHNISAEQKFLKDL 206
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 129-379 7.49e-39

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 140.47  E-value: 7.49e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169 129 KYDPPFGFRKFS-SKVQSLLDML--PEHDFPEHLRA--KACKRCVVVGNGGILHGLELGHALNQFDVVIRLNSAPVEGYS 203
Cdd:cd23964  42 HYKLPFGWGGLNrEVVERLLRNLnlTSSRYMFVLRGgrPRCIRCAVVGNGGILNGSGKGKEIDAHDYVFRVNHALTKGFE 121

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169 204 EHVGNKTTIRMTYPEGAPLSDVEYYAND---LFVTVLFKSVDFKWLQAMVKNESLPFWVRLFFWKQVAEKVPLQPKHFRI 280
Cdd:cd23964 122 KDVGTKTSFYTFFPESLHNSLLKHVPQDkdtKYLFIPFKIRDYDYLDAVLSGKPVPDGCDKGKRPPPLFGPKLNATNVRL 201

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169 281 LNPviiketafDILQYSepqsrFWGH----DKNIPTIGVIAVVLATHLCDEVSLAGFGYDlsqPRTPLHYFDSQcmgamh 356
Cdd:cd23964 202 LHP--------DFIRYL-----FNRWlnssTSYRPTTGALMLLTALHTCDQVSVYGFGYD---PRFSLHYYDKT------ 259

                       250       260
                ....*....|....*....|....*....
gi 78126169 357 WQVM------HNVTTETKFLLKLLKEGVV 379
Cdd:cd23964 260 FVKFtvfyanHDFTNERKLWRKLHEEGII 288
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 92-377 5.10e-34

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 127.40  E-value: 5.10e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169  92 CRPRYAKTAMALLFEDRYSINLEPfvqkVPTASEAELKYD--------PPFGFRKFSSKVQSLLDMLPEHDFPEHLRAKA 163
Cdd:cd23966   1 CRRCVQEGGDSDWFDERFNPSIEP----LLTRKNKELPPDvlkwwlslQSSKNSDLREVLEKLFQVVPGENPYRTRDPNR 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169 164 CKRCVVVGNGGILHGLELGHALNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAplsdVEYYANDLFVTVLFKSVDF 243
Cdd:cd23966  77 CRRCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKGFEKDVGSKTTHHFMYPESA----VDLDPGVHLVLVPFKVLDL 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169 244 KWLQAMVKNESLpfwvrLFFWKQVAEKVPLQPKHFRILNPVIIKETAFDILQysepqsrfwGHDKnIPTIGVIAVVLATH 323
Cdd:cd23966 153 QWLISALTTGEI-----TRTYTPVKRFIKADKDKVLVINPAFIKYVHDNWTE---------HHGR-YPSTGFLALIFALH 217

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 78126169 324 LCDEVSLAGFGYDlSQPRTPlHYFD-SQCMGAMHWQVMHNVTTETKFLLKLLKEG 377
Cdd:cd23966 218 ICDEVSVFGFGAD-SKGNWH-HYWEkNRSAGAFRKTGVHDADFESDIIKKLAKEG 270
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 167-373 1.25e-31

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 118.62  E-value: 1.25e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169 167 CVVVGNGGILHGLELGHALNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPlsdvEYYANDLFVTVLFKSvdfKWL 246
Cdd:cd19952   1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTKGFEKDVGSKTTFRVLNSKWAG----FYLRGPRCGCHPLPL---EEE 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169 247 QAMVKnesLPFWVRLFFWkqVAEKVPLQPKhfrilNPVIIKETAFDILQY---SEPQSR-FWGHDKNIPTIGVIAVVLAT 322
Cdd:cd19952  74 VVLIL---SRAAAADFKR--LKRRKKRHDN-----AVLLLTDPAPDLLSYvrkRLEKLGlKSFFGGNAPSSGLLAVLLAL 143

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 78126169 323 HLCDEVSLAGFGYD-LSQPRTPLHYFDSQCMGAMHWQvmHNVTTETKFLLKL 373
Cdd:cd19952 144 QLCDSVDLYGFGVDsGHAPKVPYHYYDLVEAEEGTAV--HSFDLEAELLRAL 193
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 165-379 7.61e-23

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 96.95  E-value: 7.61e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169 165 KRCVVVGNGGILHGLELGHALNQFDVVIRLNSAPVEGYSEHVGNKT--------TIRMTYPEGAPLSDVEYYANDLfvtv 236
Cdd:cd23963  64 KTCAVVGNSGILLGSGCGKEIDSHDFVIRCNLPPIKGFEKDVGRKTnlttlnpsILKRRYNSLKKNRDRDKFLNRL---- 139

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169 237 lfksvdfKWLQAMVkneslpFWVRLFFWKQVAEKVPLQPKHFRILNPVIikETAFDILQYSEPQSRFWG--HDKNIPTIG 314
Cdd:cd23963 140 -------KEYNGSI------LWYPKFSFKSSTNLLLKAARALKKNGLNL--TVVYSNPEHFLAVQKFWKrrGLEKRPSTG 204

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 78126169 315 VIAVVLATHLCDEVSLAGF---GYDlSQPRT-PLHYFDSqcMGAMHWQVMHNVTTETKFLLKLLKEGVV 379
Cdd:cd23963 205 LYLVSLALTFCDEIHLYGFwpfPTD-PNGRPvPYHYYDD--LSPSTKNKVHNMPEEFKLLRELHKKGVL 270
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 143-336 1.34e-22

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 96.10  E-value: 1.34e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169 143 VQSLLDMLP-EHDFPEHLRAKACKRCVVVGNGGILHGLELGHALNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEgap 221
Cdd:cd23980  59 IRELFQVVPgNVDPLLEKRLVSCRRCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAPTEGFEADVGSKTTHHFVYPE--- 135

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169 222 lSDVEYYANDLFVTVLFKSVDFKWLQAMVKNESLPfwvrlFFWKQVAEKVPLQPKHFRILNPVIIKETAFDILQysepqs 301
Cdd:cd23980 136 -SFRELAQNVSMILVPFKTLDLEWVISATTTGTIS-----HTYVPVPRKIKVKKEKILIYHPAFIKYVFDRWLQ------ 203

                       170       180       190
                ....*....|....*....|....*....|....*
gi 78126169 302 rfwGHDKnIPTIGVIAVVLATHLCDEVSLAGFGYD 336
Cdd:cd23980 204 ---GHGR-YPSTGILSVIFSLHVCDEVDLYGFGAD 234
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 92-380 2.29e-22

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 95.71  E-value: 2.29e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169  92 CRPRYAKTAMALLFEDRYSINLEPFVQKVPTASEAELKY-----DPPFGFRKFSSKVQSLLDMLPEHDFPEHLRAKACKR 166
Cdd:cd23979   3 CRRCVGDPGVSDWFDEHYDPDISPVWTKENMELPPDVQYwwmmlQPQFKPHNTKEVLSKLFQIIPGENPYRSWDPSRCRR 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169 167 CVVVGNGGILHGLELGHALNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPlsdvEYYANDLFVTVLFKSVDFKWL 246
Cdd:cd23979  83 CAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTVGFEADVGSRTTHHFMYPESAK----NLPANVSFVLVPFKTLDLLWI 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169 247 QAMVKNESLPfwvrlFFWKQVAEKVPLQPKHFRILNPVIIKETafdilqysepQSRFWGHDKNIPTIGVIAVVLATHLCD 326
Cdd:cd23979 159 TSALSTGQIR-----FTYAPVKQFLRVDKDKVQIYNPAFFKYI----------HDRWTEHHGRYPSTGMLVLFFALHVCD 223

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 78126169 327 EVSLAGFGYDlsqPRTPLHYF--DSQCMGAMHWQVMHNVTTETKFLLKLLKEGVVE 380
Cdd:cd23979 224 EVNVYGFGAD---SRGNWHHYweNNRYAGEFRKTGVHDADFEAHIIDMLAKAGKIK 276
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 145-379 1.80e-20

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 90.53  E-value: 1.80e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169 145 SLLDMLPEHdfpEHLRAKACKRCVVVGNGGILHGLELGHALNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPegaplSD 224
Cdd:cd23970  52 NLRSLLPEV---SPFQNKHYNTCAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPTEGFEKDVGRKTNLTTFNP-----SI 123

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169 225 VEYYANDLFvTVLFKSVDFKWLQAMvknESLPFWVRLFFWKQVAEKvplqpkhFRILNPVIIK-------ETAF--DILQ 295
Cdd:cd23970 124 LEKYYNNLL-TIQDRNNFFLSLKKL---DGAILWIPAFFFHTSATV-------TRTLVDFFVEhrgqlkvQLAWpgNIMQ 192

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169 296 YSepqSRFW----GHDKNIPTiGVIAVVLATHLCDEVSLAGF---GYDLSQPRTPLHYFDSQ-CMGAMHWQVMHNVTTET 367
Cdd:cd23970 193 HV---NRYWktkhLSPKRLST-GILMYTLASAICEEIHLYGFwpfGFDPTGTPLPYHYYDKKgTKFTTKWQESHQLPAEF 268

                       250
                ....*....|..
gi 78126169 368 KFLLKLLKEGVV 379
Cdd:cd23970 269 VLLYKMHGAGVL 280
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 148-382 1.69e-19

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 87.07  E-value: 1.69e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169 148 DMLPEHDFPEHLRAkaCKRCVVVGNGGILHGLELGHALNQFDVVIRLNSAPVEGYSEHVGNKTTIR------MTYPEGAP 221
Cdd:cd23985  31 GYLPKKSLREEVGP--LGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPTAGFQQDVGTKTTIRlinsqlVTTEKHKF 108

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169 222 LSDVEYYANDLFVtvlfksvdfkWLQAmVKNESLPFWVRL----FF--WKQVAEKVPLQPkhFRILNPVIIKETaFDILQ 295
Cdd:cd23985 109 LKDSLYNEGILIV----------WDPA-PYHSDIPEWYKNpdynFFenYKTYRRLNPNQP--FYILHPQMQWEL-WDIIQ 174

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169 296 YSEPQSRfwghDKNIPTIGVIAVVLATHLCDEVSLAGFgydL-SQPRTPL-----HYFDSQC-MGAMHwQVMHNvttetK 368
Cdd:cd23985 175 ENSPEEI----QPNPPSSGMLGIILMMTLCDQVDVYEF---LpSKRKTDVchyyqKFFDRACtMGAYH-PLLYE-----K 241

                       250
                ....*....|....
gi 78126169 369 FLLKLLKEGVVEDL 382
Cdd:cd23985 242 NLVKHLNQGTDEDI 255
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 165-382 2.63e-19

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 86.56  E-value: 2.63e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169 165 KRCVVVGNGGILHGLELGHALNQFDVVIRLNSAPVEGYSEHVGNKTTIR------MTYPEGAPLSDVEYYANDLFV--TV 236
Cdd:cd23968  46 NTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPTKGFEKDVGSKTTLRlinsqiLSKPEFNFLTDPLYRNVTLLVwdPS 125

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169 237 LFKSVDFKWLqamvKNESLPFWVRLFFWKQVAEKvplqpKHFRILNPVIIKEtAFDILQYSEPQSRFwghdKNIPTIGVI 316
Cdd:cd23968 126 SYNVNLEKWY----KKPDFDFFPNYIKYRRRHPE-----EPFYLIDPRFLWR-LWDILQEYTPEKIK----PNPPSSGFI 191

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 78126169 317 AVVLATHLCDEVSLagFGYDLSQPRTPL-HYFDSQC-----MGAmhWqvmHNVTTEtKFLLKLLKEGVVEDL 382
Cdd:cd23968 192 GIVLMLHLCDWVDV--YEYVPSVRQTDRcHYYDVEKdlactLGA--W---HPLAAE-KLLVRHLNVGSDDDI 255
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 130-348 1.66e-18

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 85.19  E-value: 1.66e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169 130 YDPPFGFRKFS----SKVQSLLDMLPEHDFPEHLRAKA--CKRCVVVGNGGILHGLELGHALNQFDVVIRLNSAPVEGYS 203
Cdd:cd23973  43 FNPPFGFMGLNytlvKEVVELIPKPKEQQLLALSPPGGdgCIRCAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVIKGYE 122

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169 204 EHVGNKTTI-----------RMTYPE----GAPL-SDVEYyandlfVTVLFKSVDFKWLQAMVKNESLPfwvRLFFWKQV 267
Cdd:cd23973 123 EDVGTRTSFyvhtahsitssLMILQKrgfkNIPQdKDIKY------ILFPEGPRDYQWLEALLKNKTIP---SGAYYGRR 193

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169 268 AEKV---PLQPKHFRILNPVIIKETAFDILQYSEPQSRFWGHDKniPTIGVIAVVLATHLCDEVSLAGF---GYDlsqpR 341
Cdd:cd23973 194 PRSYfsgDFTEDKYLVLHPDFLRYVKNRFLRSKTLKGKYWAIYR--PTTGAFLLLTALHLCDTVSAYGFiteDYR----K 267


                ....*..
gi 78126169 342 TPLHYFD 348
Cdd:cd23973 268 YPDHYYD 274
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 144-380 9.64e-18

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 82.68  E-value: 9.64e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169 144 QSLLDMLPEhdfPEHLRAKACKRCVVVGNGGILHGLELGHALNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPegaplS 223
Cdd:cd23987  47 QNLYELLPR---TSPLKNKHFKTCAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEEYAKDVGTKTDLVTMNP-----S 118

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169 224 DVEYYANDLfvtvlfksVDFKWLQAMVK-----NESLpFWVRLFFWKQVAEKVplqpkhfRILNPVIIK-----ETAFDI 293
Cdd:cd23987 119 VVQRAFEDL--------VNETWKEKFLQrlqslNGSI-LWIPAFMAKGGEERV-------EWVNDLILKhhinvRTAYPS 182

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169 294 LQYSEPQSRFWGHDK---NIPTIGVIAVVLATHLCDEVSLAG---FGYDLSQPRTPLHYFDSQCMGAMHWQVMHNVTTET 367
Cdd:cd23987 183 LRLLHAVRGYWLTNKvhiKRPTTGLLMYTLATRFCNRIHLYGfwpFPRDQNQNPVKYHYYDSLKYGYTSQASPHTMPLEF 262

                       250
                ....*....|...
gi 78126169 368 KFLLKLLKEGVVE 380
Cdd:cd23987 263 KALKNLHQQGALK 275
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 144-378 3.92e-15

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 74.76  E-value: 3.92e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169 144 QSLLDMLPEHDfPehLRAKACKRCVVVGNGGILHGLELGHALNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPls 223
Cdd:cd23969  47 QDLYQLLPEVS-P--LKGKHFRTCAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPVEGYEKDVGTKSNLTTMNPSVIP-- 121

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169 224 dvEYYANDLFVTVLFKSVDfkwlqamvkneslpfwvRLffwKQVAEKVPLQP--------KHFRILNPVIIKE-----TA 290
Cdd:cd23969 122 --HAYGDLVNATDKEKFVE-----------------RL---RQLGDSILWIPafvskggeEHVQWTNEIILKHklnvkTA 179

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169 291 FDILQYSEPQSRFWGHDK---NIPTIGVIAVVLATHLCDEVSLAG---FGYDLSQPRTPLHYFDSQCMGAMHWQvmHNVT 364
Cdd:cd23969 180 YPPLRLNHAIRGYWLTTKfriKRPSTGLLMYTLATRFCDEIHLYGfypFSEDGNGRAVKYHYYDNRKYLTTARP--HKMP 257

                       250
                ....*....|....
gi 78126169 365 TETKFLLKLLKEGV 378
Cdd:cd23969 258 EEFRALRSLHQRGA 271
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 137-348 6.10e-15

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 74.22  E-value: 6.10e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169 137 RKFSSKVQSLLDMLPEhdfPEHLRAKACKRCVVVGNGGILHGLELGHALNQFDVVIRLNSAPVEGYSEHVG--------N 208
Cdd:cd23988  40 RRTLNISQNLHSLLPE---VSPMKNRRFKTCAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPVVEFAADVGtksdfitmN 116

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169 209 KTTIRMTYPEGAPLSDVEYYANDLfvTVLFKSVdfKWLQA-MVKNESlpfwvrlffwkqvaekvplqpKHFRILNPVIIK 287
Cdd:cd23988 117 PSVVQRAFGGFRNESDREKFVHRL--SMLNDSV--LWIPAfMVKGGE---------------------KHVEWVNALILK 171

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 78126169 288 -----ETAFDILQYSEPQSRFWGHDK-NI--PTIGVIAVVLATHLCDEVSLAG---FGYDLSQPRTPLHYFD 348
Cdd:cd23988 172 nklkvRTAYPSLRLIHAVRGYWLTNKvNIkrPSTGLLMYTLATRFCDEIHLYGfwpFPKDANGNPVKYHYYD 243
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 127-379 1.00e-14

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 73.45  E-value: 1.00e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169 127 ELKYDppfGFRKFSSKV-QSLLDMLPEhDFPehLRAKACKRCVVVGNGGILHGLELGHALNQFDVVIRLNSAPVEgYSEH 205
Cdd:cd23971  32 KIHYE---GERKKTITVnEKLFSMLPK-ESP--FSNKPLKTCAVVGNGGILKNSSCGREIDSADFVIRCNLPPLN-DSKD 104

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169 206 VGNKT----------TIRMTYPEGAPLS---DVEYYANDLFVTVLFksvdfkwlqAMVKNESLPFwvRLFFwkqVAEKVP 272
Cdd:cd23971 105 VGSKTnlvtanpsilREKFHNLKKRRRPfveRMKVYGNALLLLPAF---------SYTSNTEPSL--RALY---TLEDFG 170

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169 273 LQPKHFrILNPviiketafdilQYSEPQSRFWgHDKNIPTI----GVIAVVLATHLCDEVSLAGF---GYDLSQPRTPLH 345
Cdd:cd23971 171 SPQKVL-FFNP-----------EYLRNLSRYW-KSKGLKARrlstGLMLVSAALELCENVHLYGFwpfSTDLDGNPISHH 237

                       250       260       270
                ....*....|....*....|....*....|....
gi 78126169 346 YFDSQCMGamhwQVMHNVTTETKFLLKLLKEGVV 379
Cdd:cd23971 238 YYDNVLPK----KGVHAMPEEFLRYLKLHSQGVL 267
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 129-380 1.48e-14

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 73.70  E-value: 1.48e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169 129 KYDPPFGFRKFSSK-VQSLLDMLPEHD----FPEHLRAKACKRCVVVGNGGILHGLELGHALNQFDVVIRLNSAPVEGYS 203
Cdd:cd23972  42 QRKVPYGWKGLSHQvVASTLSLLNDSAnaklFFPRDTPGKCIRCAVVGNGGILNGSRQGRAIDAHDYVFRLNGAVIKGFE 121

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169 204 EHVGNKTTIRMTYPEGAPLSDVEYYA---------NDL-FVTVLFKSVDFKWLQAMVKNESLPF-------WVRLFFWKQ 266
Cdd:cd23972 122 EDVGTKTSFYGFTVNTMKNSLISYWNlgftrtpqgQDLqYIFIPSDIRDYVMLRSAILGVPVPEgldkgdrPHKYFGPEA 201

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169 267 VAEKvplqpkhFRILNPVIIKETAFDILQySEPQSRFWGHdKNIPTIGVIAVVLATHLCDEVSLAGFGYDlSQPRTPLHY 346
Cdd:cd23972 202 SAKK-------FKLLHPDFISYLTDRFLK-SKLLNTHYGH-LYMPSTGALMLLTALHTCDQVSAYGFITS-NYWKFSDHY 271

                       250       260       270
                ....*....|....*....|....*....|....
gi 78126169 347 FDSQcMGAMHWQVMHNVTTETKFLLKLLKEGVVE 380
Cdd:cd23972 272 YERK-KKPLVFYANHDMLLEAALWRRLHKAGILQ 304
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 131-382 1.65e-14

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 72.95  E-value: 1.65e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169 131 DPPF---GFRKFSSKVQslLDMLPEHDFpehlrakacKRCVVVGNGGILHGLELGHALNQFDVVIRLNSAPVEGYSEHVG 207
Cdd:cd23986  24 EAPFsalGWEKYVPKIP--LSKLHLRGF---------RSCAVVTSAGAILNSSLGKEIDSHDAVLRFNSAPTRGYEKDVG 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169 208 NKTTIRMTYPEgaPLSDVEYYANDlfvTVLFKSVdfkwlqAMVKNESLPFWVRLFFW------------KQVAEKVPLQP 275
Cdd:cd23986  93 NKTTIRIINSQ--ILTNPNHHFID---SSLYKDV------ILVAWDPAPYSANLHKWykkpdynlftpyVQYRKRNPNQP 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169 276 khFRILNPVIIKETaFDILQYSEPQSRfwghDKNIPTIGVIAVVLATHLCDEVSLagFGYDLSQPRTPL-----HYFDSQ 350
Cdd:cd23986 162 --FYILHPKFIWQL-WDIIQENTQEKI----QPNPPSSGFIGILIMMSMCREVHV--YEYIPSVRQTDLchyheRYYDAA 232

                       250       260       270
                ....*....|....*....|....*....|...
gi 78126169 351 C-MGAMHwQVMHNvttetKFLLKLLKEGVVEDL 382
Cdd:cd23986 233 CtLGAYH-PLLYE-----KLLIQRMNKGTEDDL 259
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 164-349 1.43e-12

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 66.50  E-value: 1.43e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169 164 CKRCVVVGNGGILHGLELGHALNQFDVVIRLNSAPVEGYSEHVGNKTTIRMtypegaplsdveyyandlfvtVLFKSVDF 243
Cdd:cd23965   1 CDTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRGYEKDVGRRTTIRV---------------------VSHSSLPR 59

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169 244 KWLQAMVKNESLPFWVRLFFW-------KQVAEKVP----LQPKH----FRILNPVIIKETAFDILQY---SEPQSRFWg 305
Cdd:cd23965  60 LLRNAILLLAGTRAPTVVVFWgpetkmnKDGAGKYNllrsLSKKYpdveFYSLTPEKMDYADELFEKEtgkSRIKSGTW- 138

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 78126169 306 hdknIPTiGVIAVVLATHLCDEVSLAGFGYD-----LSQPRTPLHYFDS 349
Cdd:cd23965 139 ----LST-GWFTMLLALDVCDEIKVYGMVPEnycreHPNSKVPYHYYEP 182
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 164-379 2.48e-12

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 67.08  E-value: 2.48e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169 164 CKRCVVVGNGGILHGLELGHALNQFDVVIRLNSAPVEGYSEHVGNKTTIrMTYPEGAPLSDVEYYANDLFvTVLFKSVDF 243
Cdd:cd23974  84 CIRCAVVGNGGILNGSRMGAEIDGHDYVFRVNGAITKGFEKDVGRRTSF-YTFSTNTLMNSLRAYAGVGF-NGPPQSKET 161

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169 244 KWLqamvkneSLPFWVRLFFWKQVA------EKVP-------------LQPKHFRILNPviiketafDILQYSepQSRFW 304
Cdd:cd23974 162 RYI-------FLPDHDRDYLLVKAAlthtpiDRGRdkskrpskyfgkdVTAEKFKIYHP--------DFIRYL--RNRFL 224

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169 305 GH------DKNI--PTIGVIAVVLATHLCDEVSLAGF---GYDLSQPrtplHYFDSQcMGAMHWQVMHNVTTETKFLLKL 373
Cdd:cd23974 225 WSpilntkQRDIyrPSTGAVMLLAALHTCDQVSAYGFmtpDYGKYSD----HYYDKT-YHKVVFYANHDLRLEMQLWQKL 299


                ....*.
gi 78126169 374 LKEGVV 379
Cdd:cd23974 300 HKAGLI 305
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 116-361 3.86e-11

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 62.93  E-value: 3.86e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169 116 FVQKVPTASEAELKYD-PPFGFRKFSSKVqslLDMLPEhDFPEHlRAKAcKRCVVVGNGGILHGLELGHALNQFDVVIRL 194
Cdd:cd23990  21 FTTQKNTPLGTKLKYEvDTSGIYHINSEI---FKMFPK-DMPYS-RSQF-KKCAVVGNGGILKNSKCGREIDSADFVFRC 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169 195 NSAPV-EGYSEHVGNKTTIRMTYPEgaplsdveyyandlFVTVLFKSVDfKWLQamvkneslPFWVRLffwkQVAEKVP- 272
Cdd:cd23990  95 NLPPIsEKYVRDVGVKTDVVTINPS--------------IITERFHKLE-KWRR--------PFYEVL----QVYENASv 147

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169 273 LQPKHFRILNPVIIKETAFDILQYSEPQ-------------SRFWG----HDKNIPTiGVIAVVLATHLCDEVSLAGFG- 334
Cdd:cd23990 148 VLPAFYNTRNTDVSIRVKYVLDDFESQQavyyfhpqyllnvSRFWLrqgvRAKRISS-GLMLVTAALELCEEVHLYGFWa 226

                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 78126169 335 --------------YDLSQPRTPLHYFDSQCMGAMHwqvMH 361
Cdd:cd23990 227 fpmnpsgifithhyYDNVKPRPGFHAMPSEIFNFLH---MH 264
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 116-379 2.82e-09

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 57.46  E-value: 2.82e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169 116 FVQKVPTASEAELKYDPPFGfRKFSSKvQSLLDMLPEHdfpEHLRAKACKRCVVVGNGGILHGLELGHALNQFDVVIRLN 195
Cdd:cd23991  21 IVSQNNTPLGTNLTYEVEPK-KKILIT-ENIFRMFPKS---QPFRGYPYKQCAVVGNGGILKNSSCGAEIDQADFVFRCN 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169 196 SAPVEG-YSEHVGNKTT--------IRMTYPE----GAP-LSDVEYYANDLFvtvLFKSVDFKwlqamvKNESLPFWVRL 261
Cdd:cd23991  96 LPPTGGnISKDVGSKTNlvtanpsiISIKYAKlnerRKPfLETVSVYGDAFL---LLPAFSYR------SNTALSFKVYY 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169 262 FFWKQVAEKVPLqpkhfrILNPVIIKETAfdilqysepqsRFWG----HDKNIPTiGVIAVVLATHLCDEVSLAG---FG 334
Cdd:cd23991 167 TLEDFKAKQKVI------FFHPIYLKHLA-----------QFWRskgvQVYRLST-GLMITSAALELCEEVKLYGfwpFS 228

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 78126169 335 YDLSQPRTPLHYFDSQcmgaMHWQVMHNVTTETKFLLKLLKEGVV 379
Cdd:cd23991 229 KNTEGKPISHHYYDNQ----LPKPGFHSMPKEFYQLLQLHSKGIL 269
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 164-348 3.33e-09

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 56.80  E-value: 3.33e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169 164 CKRCVVVGNGGILHGLELGHALNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTypegaplsdveyyANDLFVTVLFKSVDf 243
Cdd:cd23976  15 CKSCALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSLRVI-------------AHSSIQRILRNRNE- 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169 244 kwLQAMVKNESLPFWVRLFFWKQVAEKvpLQPKHFRILNPVIIKETAFDI-----LQYSEPQSRFWGHDKNIP----TIG 314
Cdd:cd23976  81 --LLNVSQGTVFIFWGPSNYMRRDGKG--LVYNNLQLMNQILPKLKVYTItrhkmLQFDELFKRETGKDRKISntwlSTG 156

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 78126169 315 VIAVVLATHLCDEVSLAG-----FGYDLSQPRTPLHYFD 348
Cdd:cd23976 157 WFTMIIALELCDRINVYGmvppdFCRDPNHPSVPYHYYE 195
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 164-222 3.38e-09

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 56.79  E-value: 3.38e-09
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 78126169 164 CKRCVVVGNGGILHGLELGHALNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPL 222
Cdd:cd23977   1 CRRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSSLRVVSHTSVPL 59
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 164-214 3.60e-09

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 56.79  E-value: 3.60e-09
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 78126169 164 CKRCVVVGNGGILHGLELGHALNQFDVVIRLNSAPVEGYSEHVGNKTTIRM 214
Cdd:cd23978   1 CHQCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTLRV 51
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 164-228 4.29e-08

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 53.40  E-value: 4.29e-08
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 78126169 164 CKRCVVVGNGGILHGLELGHALNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPL--SDVEYY 228
Cdd:cd23975   1 CDLCAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTIRVVSHTSVPLllKNPDYF 67
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 165-379 1.91e-06

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 49.06  E-value: 1.91e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169 165 KRCVVVGNGGILHGLELGHALNQFDVVIRLNSAPV-EGYSEHVGNKTTIrmtypegaplsdveYYANDLFVTVLFKSVDF 243
Cdd:cd23989  64 KKCSVVGNGGILKNSGCGQQIDRADFVMRCNLPPLsREYTDDVGTKTQL--------------VTANPSIIDKRFQNLLW 129

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78126169 244 KwLQAMVknESLPFWVRLFFW-KQVAEKVPLQPKhFRILNPVIIKETAFDILqYSEPQ-----SRFWG----HDKNIPTi 313
Cdd:cd23989 130 S-RKSFV--ESMKVYGRSYIYmPAFSMKTGTDPS-LRVYYTLADVGANQTVL-FANPNflrnvGKFWKskgvHAKRLST- 203

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 78126169 314 GVIAVVLATHLCDEVSLAG---FGYDLSQPRTPLHYFDSQcmgaMHWQVMHNVTTETKFLLKLLKEGVV 379
Cdd:cd23989 204 GLFLVSAALGLCEEVTIYGfwpFSVDLDERTISHHYYDNV----LPDSGFHAMPEEFLQLWHLHKSGVL 268
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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