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Conserved domains on  [gi|6755702|ref|NP_035644|]
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histone-lysine N-methyltransferase SUV39H1 isoform 1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SET_SUV39H1 cd10525
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 158-412 0e+00

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 1 (SUV39H1) and similar proteins; SUV39H1 (EC 2.1.1.43; also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A (KMT1A), position-effect variegation 3-9 homolog (SUV39H), or Su(var)3-9 homolog 1) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. It mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions.


:

Pssm-ID: 380923 [Multi-domain]  Cd Length: 255  Bit Score: 518.29  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  158 RSFVYINEYRVGEGITLNQVAVGCECQDCLLAPTGGCCPGASLHKFAYNDQGQVRLKAGQPIYECNSRCCCGYDCPNRVV 237
Cdd:cd10525   1 RDFVYINEYKVGEGVTLNQVAVGCECQDCLSQPVGGCCPGASKHRFAYNEQGQVKVRPGLPIYECNSRCRCGPDCPNRVV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  238 QKGIRYDLCIFRTNDGRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGATYLFDLDYVEDVYTVDAAYYGN 317
Cdd:cd10525  81 QKGIQYDLCIFRTDNGRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGATYLFDLDYVEDVYTVDAAYYGN 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  318 ISHFVNHSCDPNLQVYNVFIDNLDERLPRIAFFATRTIWAGEELTFDYNMQVDPVDMESTRMDSNFGLAGLPGSPKKRVR 397
Cdd:cd10525 161 ISHFVNHSCDPNLQVYNVFIDNLDERLPRIALFATRTIRAGEELTFDYNMQVDPVDAESTKMDSNFGLAGLPGSPKKRVR 240

                       250
                ....*....|....*
gi 6755702  398 IECKCGTTACRKYLF 412
Cdd:cd10525 241 IECKCGVRSCRKYLF 255
CD_SUV39H1_like cd18639
chromodomain of histone methyltransferase SUV39H1, and similar proteins; CHRomatin ...
 43-91 2.13e-29

chromodomain of histone methyltransferase SUV39H1, and similar proteins; CHRomatin Organization Modifier (chromo) domain of human SUV39H1, a histone lysine methyltransferase (HMT) which catalyzes di- and tri-methylation of lysine 9 of histone H3 (H3K9me2/3), leading to heterochromatin formation and gene silencing. H3K9me2/3 represents a specific mark for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3, and/or CBX5) proteins to methylated histones. SUV39H1 mainly functions in heterochromatin regions. The human SUV39H1/2, histone H3K9 methyltransferases, are the mammalian homologs of Drosophila Su(var)3-9 and Schizosaccharomyces pombe Clr4. SUV39H1 contains a chromodomain at its N-terminus and a SET domain at its C-terminus. Although the SET domain performs the catalytic activity, the chromodomain of SUV39H1 is essential for the catalytic activity of SUV39H1. A chromodomain is a conserved region of about 50 amino acids, found in a variety of chromosomal proteins, and which appears to play a role in the functional organization of the eukaryotic nucleus. The chromodomain is implicated in the binding, of the proteins in which it is found, to methylated histone tails and maybe RNA. A chromodomain may occur as a single instance, in a tandem arrangement, or followed by a related chromo shadow domain.


:

Pssm-ID: 349289  Cd Length: 49  Bit Score: 108.37  E-value: 2.13e-29
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 6755702   43 FEVEYLCDYKKIREQEYYLVKWRGYPDSENTWEPRQNLKCIRVLKQFHK 91
Cdd:cd18639   1 YEVEYLCDYKKIREQEYYLVKWKGYPDSENTWEPRQNLKCSRLLKQFHK 49
 
Name Accession Description Interval E-value
SET_SUV39H1 cd10525
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 158-412 0e+00

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 1 (SUV39H1) and similar proteins; SUV39H1 (EC 2.1.1.43; also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A (KMT1A), position-effect variegation 3-9 homolog (SUV39H), or Su(var)3-9 homolog 1) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. It mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions.


Pssm-ID: 380923 [Multi-domain]  Cd Length: 255  Bit Score: 518.29  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  158 RSFVYINEYRVGEGITLNQVAVGCECQDCLLAPTGGCCPGASLHKFAYNDQGQVRLKAGQPIYECNSRCCCGYDCPNRVV 237
Cdd:cd10525   1 RDFVYINEYKVGEGVTLNQVAVGCECQDCLSQPVGGCCPGASKHRFAYNEQGQVKVRPGLPIYECNSRCRCGPDCPNRVV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  238 QKGIRYDLCIFRTNDGRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGATYLFDLDYVEDVYTVDAAYYGN 317
Cdd:cd10525  81 QKGIQYDLCIFRTDNGRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGATYLFDLDYVEDVYTVDAAYYGN 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  318 ISHFVNHSCDPNLQVYNVFIDNLDERLPRIAFFATRTIWAGEELTFDYNMQVDPVDMESTRMDSNFGLAGLPGSPKKRVR 397
Cdd:cd10525 161 ISHFVNHSCDPNLQVYNVFIDNLDERLPRIALFATRTIRAGEELTFDYNMQVDPVDAESTKMDSNFGLAGLPGSPKKRVR 240

                       250
                ....*....|....*
gi 6755702  398 IECKCGTTACRKYLF 412
Cdd:cd10525 241 IECKCGVRSCRKYLF 255
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 243-366 9.66e-42

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 143.24  E-value: 9.66e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702     243 YDLCIFRTnDGRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGA--TYLFDLDyveDVYTVDAAYYGNISH 320
Cdd:smart00317   1 NKLEVFKS-PGKGWGVRATEDIPKGEFIGEYVGEIITSEEAEERPKAYDTDGAkaFYLFDID---SDLCIDARRKGNLAR 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 6755702     321 FVNHSCDPNLQVYNVFIDNLDerlpRIAFFATRTIWAGEELTFDYN 366
Cdd:smart00317  77 FINHSCEPNCELLFVEVNGDD----RIVIFALRDIKPGEELTIDYG 118
CD_SUV39H1_like cd18639
chromodomain of histone methyltransferase SUV39H1, and similar proteins; CHRomatin ...
 43-91 2.13e-29

chromodomain of histone methyltransferase SUV39H1, and similar proteins; CHRomatin Organization Modifier (chromo) domain of human SUV39H1, a histone lysine methyltransferase (HMT) which catalyzes di- and tri-methylation of lysine 9 of histone H3 (H3K9me2/3), leading to heterochromatin formation and gene silencing. H3K9me2/3 represents a specific mark for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3, and/or CBX5) proteins to methylated histones. SUV39H1 mainly functions in heterochromatin regions. The human SUV39H1/2, histone H3K9 methyltransferases, are the mammalian homologs of Drosophila Su(var)3-9 and Schizosaccharomyces pombe Clr4. SUV39H1 contains a chromodomain at its N-terminus and a SET domain at its C-terminus. Although the SET domain performs the catalytic activity, the chromodomain of SUV39H1 is essential for the catalytic activity of SUV39H1. A chromodomain is a conserved region of about 50 amino acids, found in a variety of chromosomal proteins, and which appears to play a role in the functional organization of the eukaryotic nucleus. The chromodomain is implicated in the binding, of the proteins in which it is found, to methylated histone tails and maybe RNA. A chromodomain may occur as a single instance, in a tandem arrangement, or followed by a related chromo shadow domain.


Pssm-ID: 349289  Cd Length: 49  Bit Score: 108.37  E-value: 2.13e-29
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 6755702   43 FEVEYLCDYKKIREQEYYLVKWRGYPDSENTWEPRQNLKCIRVLKQFHK 91
Cdd:cd18639   1 YEVEYLCDYKKIREQEYYLVKWKGYPDSENTWEPRQNLKCSRLLKQFHK 49
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 255-366 2.53e-29

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 110.31  E-value: 2.53e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702    255 GWGVRTLEKIRKNSFVMEYVGE-IITSEEAERRGQIY-----DRQGATYLFDLDyVEDVYTVD--AAYYGNISHFVNHSC 326
Cdd:pfam00856   1 GRGLFATEDIPKGEFIGEYVEVlLITKEEADKRELLYydkleLRLWGPYLFTLD-EDSEYCIDarALYYGNWARFINHSC 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 6755702    327 DPNLQVYNVFIDnldeRLPRIAFFATRTIWAGEELTFDYN 366
Cdd:pfam00856  80 DPNCEVRVVYVN----GGPRIVIFALRDIKPGEELTIDYG 115
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
249-375 2.47e-27

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 105.43  E-value: 2.47e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  249 RTNDGRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIyDRQGATYLFDLDyveDVYTVDAAYYGNISHFVNHSCDP 328
Cdd:COG2940  11 RPSPIHGRGVFATRDIPKGTLIGEYPGEVITWAEAERREPH-KEPLHTYLFELD---DDGVIDGALGGNPARFINHSCDP 86

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 6755702  329 NLQvynvfidnLDERLPRIAFFATRTIWAGEELTFDYNMQVDPVDME 375
Cdd:COG2940  87 NCE--------ADEEDGRIFIVALRDIAAGEELTYDYGLDYDEEEYP 125
Chromo pfam00385
Chromo (CHRromatin organization MOdifier) domain;
43-91 8.86e-14

Chromo (CHRromatin organization MOdifier) domain;


Pssm-ID: 459793 [Multi-domain]  Cd Length: 52  Bit Score: 65.29  E-value: 8.86e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 6755702     43 FEVEYLCDYKKIREQ-EYYLVKWRGYPDSENTWEPRQNL-KCIRVLKQFHK 91
Cdd:pfam00385   1 YEVERILDHRKDKGGkEEYLVKWKGYPYDENTWEPEENLsKCPELIEEFKD 51
CHROMO smart00298
Chromatin organization modifier domain;
42-92 6.16e-11

Chromatin organization modifier domain;


Pssm-ID: 214605 [Multi-domain]  Cd Length: 55  Bit Score: 57.22  E-value: 6.16e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 6755702      42 DFEVEYLCDYKKIREQEY-YLVKWRGYPDSENTWEPRQNLK-CIRVLKQFHKD 92
Cdd:smart00298   1 EYEVEKILDHRWKKKGELeYLVKWKGYSYSEDTWEPEENLLnCSKKLDNYKKK 53
 
Name Accession Description Interval E-value
SET_SUV39H1 cd10525
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 158-412 0e+00

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 1 (SUV39H1) and similar proteins; SUV39H1 (EC 2.1.1.43; also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A (KMT1A), position-effect variegation 3-9 homolog (SUV39H), or Su(var)3-9 homolog 1) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. It mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions.


Pssm-ID: 380923 [Multi-domain]  Cd Length: 255  Bit Score: 518.29  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  158 RSFVYINEYRVGEGITLNQVAVGCECQDCLLAPTGGCCPGASLHKFAYNDQGQVRLKAGQPIYECNSRCCCGYDCPNRVV 237
Cdd:cd10525   1 RDFVYINEYKVGEGVTLNQVAVGCECQDCLSQPVGGCCPGASKHRFAYNEQGQVKVRPGLPIYECNSRCRCGPDCPNRVV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  238 QKGIRYDLCIFRTNDGRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGATYLFDLDYVEDVYTVDAAYYGN 317
Cdd:cd10525  81 QKGIQYDLCIFRTDNGRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGATYLFDLDYVEDVYTVDAAYYGN 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  318 ISHFVNHSCDPNLQVYNVFIDNLDERLPRIAFFATRTIWAGEELTFDYNMQVDPVDMESTRMDSNFGLAGLPGSPKKRVR 397
Cdd:cd10525 161 ISHFVNHSCDPNLQVYNVFIDNLDERLPRIALFATRTIRAGEELTFDYNMQVDPVDAESTKMDSNFGLAGLPGSPKKRVR 240

                       250
                ....*....|....*
gi 6755702  398 IECKCGTTACRKYLF 412
Cdd:cd10525 241 IECKCGVRSCRKYLF 255
SET_SUV39H cd10542
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 160-411 3.65e-141

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homologs, SUV39H1, SUV39H2 and similar proteins; This family includes SUV39H1 (also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A, KMT1A, position-effect variegation 3-9 homolog, SUV39H, or Su(var)3-9 homolog 1) and SUV39H2 (also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B, KMT1B, or Su(var)3-9 homolog 2), both act as histone-lysine N-methyltransferases that specifically trimethylate 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. They mainly function in heterochromatin regions, thereby playing central roles in the establishment of constitutive heterochromatin at pericentric and telomere regions. Also included are Schizosaccharomyces pombe H3K9 methyltransferase Clr4 (SUV39H homolog) and Neurospora crassa DIM-5, both of which also methylate 'Lys-9' of histone H3.


Pssm-ID: 380940 [Multi-domain]  Cd Length: 245  Bit Score: 402.44  E-value: 3.65e-141
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  160 FVYINEYRVGEGITLNQ-VAVGCECQ-DCLLAPTGgCCPGASLHKFAYNDQGQVRLKAGQPIYECNSRCCCGYDCPNRVV 237
Cdd:cd10542   3 FQYINDYIPGDGVKIPEdFLVGCECTeDCHNNNPT-CCPAESGVKFAYDKQGRLRLPPGTPIYECNSRCKCGPDCPNRVV 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  238 QKGIRYDLCIFRTNDGRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGATYLFDLDYVED--VYTVDAAYY 315
Cdd:cd10542  82 QRGRKVPLCIFRTSNGRGWGVKTLEDIKKGTFVMEYVGEIITSEEAERRGKIYDANGRTYLFDLDYNDDdcEYTVDAAYY 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  316 GNISHFVNHSCDPNLQVYNVFIDNLDERLPRIAFFATRTIWAGEELTFDYNMQVDPVDMESTrmdsnfglaglpGSPKKR 395
Cdd:cd10542 162 GNISHFINHSCDPNLAVYAVWINHLDPRLPRIAFFAKRDIKAGEELTFDYLMTGTGGSSEST------------IPKPKD 229

                       250
                ....*....|....*.
gi 6755702  396 VRIECKCGTTACRKYL 411
Cdd:cd10542 230 VRVPCLCGSKNCRKYL 245
SET_SUV39H2 cd10532
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 160-411 6.38e-129

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 2 (SUV39H2) and similar proteins; SUV39H2 (EC 2.1.1.43; also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B (KMT1B), or Su(var)3-9 homolog 2) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. It mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions.


Pssm-ID: 380930 [Multi-domain]  Cd Length: 243  Bit Score: 371.15  E-value: 6.38e-129
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  160 FVYINEYRVGEGITL-NQVAVGCECQDCllaPTGGCCPGASLHKFAYNDQGQVRLKAGQPIYECNSRCCCGYDCPNRVVQ 238
Cdd:cd10532   3 FYYINEYKPAPGINLdNEATVGCDCSDC---FFGKCCPAEAGVLFAYNEHGQLKIPPGTPIYECNSRCKCGPDCPNRVVQ 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  239 KGIRYDLCIFRTNDGRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGATYLFDLDYVEDVYTVDAAYYGNI 318
Cdd:cd10532  80 KGTQYSLCIFRTSNGRGWGVKTLQKIKKNSFVMEYVGEVITSEEAERRGQFYDSKGITYLFDLDYESDEFTVDAARYGNV 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  319 SHFVNHSCDPNLQVYNVFIDNLDERLPRIAFFATRTIWAGEELTFDYNMQvDPVDMESTRMDSnfglaglpGSPKKRVRI 398
Cdd:cd10532 160 SHFVNHSCDPNLQVFNVFIDNLDTRLPRIALFSTRTIKAGEELTFDYQMK-GSGDLSSDSIDN--------SPAKKRVRT 230

                       250
                ....*....|...
gi 6755702  399 ECKCGTTACRKYL 411
Cdd:cd10532 231 VCKCGAVTCRGYL 243
SET_SETDB-like cd10538
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) ...
 159-366 1.87e-83

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2, and similar proteins; The family includes SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2. SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis. SUV39H1 (also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A, KMT1A, position-effect variegation 3-9 homolog, SUV39H, or Su(var)3-9 homolog 1) and SUV39H2 (also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B, KMT1B, or Su(var)3-9 homolog 2), both act as histone-lysine N-methyltransferases that specifically trimethylate 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. They mainly function in heterochromatin regions, thereby playing central roles in the establishment of constitutive heterochromatin at pericentric and telomere regions. EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, lysine N-methyltransferase 1D, or KMT1D) and EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C, KMT1C, or protein G9a), both act as histone-lysine N-methyltransferases that specifically mono- and dimethylate 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. This family also includes the pre-SET domain, which is found in a number of histone methyltransferases (HMTase), N-terminal to the SET domain. Pre-SET domain is a zinc binding motif which contains 9 conserved cysteines that coordinate three zinc ions. It is thought that this region plays a structural role in stabilizing SET domains. Most family members, except for Arabidopsis thaliana SUVH9, contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380936 [Multi-domain]  Cd Length: 217  Bit Score: 254.22  E-value: 1.87e-83
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  159 SFVYINEYRVGEGITLNQ---VAVGCECQD-CLLAPtggC-CPGASLHKFAYNDQGQVRL-KAGQPIYECNSRCCCGYDC 232
Cdd:cd10538   2 SFTYIKDNIVGKNVQPFSniiDSVGCKCKDdCLDSK---CaCAAESDGIFAYTKNGLLRLnNSPPPIFECNSKCSCDDDC 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  233 PNRVVQKGIRYDLCIFRTNDgRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGATYLFDLDYVEDV----- 307
Cdd:cd10538  79 KNRVVQRGLQARLQVFRTSK-KGWGVRSLEFIPKGSFVCEYVGEVITTSEADRRGKIYDKSGGSYLFDLDEFSDSdgdge 157

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  308 -YTVDAAYYGNISHFVNHSCDPNLQVYNVFIDNLDERLPRIAFFATRTIWAGEELTFDYN 366
Cdd:cd10538 158 eLCVDATFCGNVSRFINHSCDPNLFPFNVVIDHDDLRYPRIALFATRDILPGEELTFDYG 217
SET_SUV39H_Clr4-like cd20073
SET domain (including pre-SET and post-SET domains) found in of Schizosaccharomyces pombe H3K9 ...
 160-412 3.19e-70

SET domain (including pre-SET and post-SET domains) found in of Schizosaccharomyces pombe H3K9 methyltransferase Clr4, and similar proteins; This subfamily contains fission yeast Schizosaccharomyces pombe H3K9 methyltransferase Clr4 (also known as Suv39h), the sole homolog of the mammalian SUV39H1 and SUV39H2 enzymes, that has a critical role in preventing aberrant heterochromatin formation. It is known to di- and tri-methylate Lys-9 of histone H3, a central heterochromatic histone modification, with its specificity profile most similar to that of the human SUV39H2 homolog.


Pssm-ID: 380999 [Multi-domain]  Cd Length: 259  Bit Score: 222.06  E-value: 3.19e-70
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  160 FVYINEYRVGEGITLNQ--VAVGCECQD---CLLAPTGGC-CPGASLHK-FAYNDQGQVRLKAGQPIYECNSRCCCGYDC 232
Cdd:cd20073   3 FEFITSYRYGLGIEPPDplFISGCSCSKlggCDLNNPGSCqCLEDSNEKsFAYDEYGRVRANTGSIIYECNENCDCGINC 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  233 PNRVVQKGIRYDLCIFRTNDgRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGATYLFDLDYVED----VY 308
Cdd:cd20073  83 PNRVVQRGRKLPLEIFKTKH-KGWGLRCPRFIKAGTFIGVYLGEVITQSEAEIRGKKYDNVGVTYLFDLDLFEDqvdeYY 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  309 TVDAAYYGNISHFVNHSCDPNLQVYNVFIDNLDERLPRIAFFATRTIWAGEELTFDYNMQVDPVDMESTRMDSNFGLAGL 388
Cdd:cd20073 162 TVDAQYCGDVTRFINHSCDPNLAIYSVLRDKSDSKIYDLAFFAIKDIPALEELTFDYSGRNNFDQLGFIGNRSNSKYINL 241

                       250       260
                ....*....|....*....|....
gi 6755702  389 pgspkkRVRIECKCGTTACRKYLF 412
Cdd:cd20073 242 ------KNKRPCYCGSANCRGWLF 259
SET_SUV39H_DIM5-like cd19473
SET domain (including pre-SET domain) found in Neurospora crassa (DIM-5) and similar proteins; ...
 159-411 6.06e-65

SET domain (including pre-SET domain) found in Neurospora crassa (DIM-5) and similar proteins; This subfamily contains Neurospora crassa DIM-5 (also termed H3-K9-HMTase dim-5, or HKMT) which functions as histone-lysine N-methyltransferase that specifically trimethylates histone H3 to form H3K9me3.


Pssm-ID: 380996 [Multi-domain]  Cd Length: 274  Bit Score: 208.71  E-value: 6.06e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  159 SFVYINEYRVGEGITLNQVA--VGCECQDCLLAPTGGC-C---------PGASLHKFAYNDQGQVR-------LKAGQPI 219
Cdd:cd19473   2 DFRFIEKSILGEGVELADEEfrSGCECTDDEDCMYSGClClqdvdpdddRDPGKKKNAYHSSGAKKgclrghmLNSRLPI 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  220 YECNSRCCCGYDCPNRVVQKGIRYDLCIFRTNDGRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRgqiydRQGAT--- 296
Cdd:cd19473  82 YECHEGCACSDDCPNRVVERGRKVPLQIFRTSDGRGWGVRSTVDIKRGQFVDCYVGEIITPEEAQRR-----RDAATiaq 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  297 ----YLFDLDYVEDV-----------YTVDAAYYGNISHFVNHSCDPNLQVYNVFIDNLDERLPRIAFFATRTIWAGEEL 361
Cdd:cd19473 157 rkdvYLFALDKFSDPdsldprlrgdpYEIDGEFMSGPTRFINHSCDPNLRIFARVGDHADKHIHDLAFFAIKDIPRGTEL 236

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 6755702  362 TFDYNMQVDPVDMESTRMDSNFGLAglpgspkkrvriECKCGTTACRKYL 411
Cdd:cd19473 237 TFDYVDGVTGLDDDAGDEEKEKEMT------------KCLCGSPKCRGYL 274
SET_SETDB1 cd10517
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) ...
 145-411 8.40e-63

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and similar proteins; SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes.


Pssm-ID: 380915 [Multi-domain]  Cd Length: 288  Bit Score: 203.67  E-value: 8.40e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  145 ITVENEVDLDGPPrSFVYINEYRVGEGITLN---QVAVGCECQD---------C--LLAPTGGCCPGASLHKFAYNDQGq 210
Cdd:cd10517  18 IPCVNEIDNSSPP-YVEYSKERIPGKGVNINldpDFLVGCDCTDgcrdkskcaCqqLTIEATAATPGGQINPSAGYQYR- 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  211 vRLKAGQP--IYECNSRCCCGYDCPNRVVQKGIRYDLCIFRTNDgRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQ 288
Cdd:cd10517  96 -RLMEKLPtgVYECNSRCKCDKRCYNRVVQNGLQVRLQVFKTEK-KGWGIRCLDDIPKGSFVCIYAGQILTEDEANEEGL 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  289 IYDRQgatYLFDLDYVEDV---------------YTVDAAYYGNISHFVNHSCDPNLQVYNVFIDNLDERLPRIAFFATR 353
Cdd:cd10517 174 QYGDE---YFAELDYIEVVeklkegyesdveehcYIIDAKSEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASR 250

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 6755702  354 TIWAGEELTFDYNMQVDPVdmestrmdsnfglaglPGSPKKrvrieCKCGTTACRKYL 411
Cdd:cd10517 251 YIRAGTELTWDYNYEVGSV----------------PGKVLY-----CYCGSSNCRGRL 287
SET_EHMT cd10543
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 160-408 1.98e-59

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase EHMT1, EHMT2 and similar proteins; This family includes EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, lysine N-methyltransferase 1D, or KMT1D) and EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C, KMT1C, or protein G9a), both act as histone-lysine N-methyltransferases that specifically mono- and dimethylate 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380941 [Multi-domain]  Cd Length: 231  Bit Score: 193.32  E-value: 1.98e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  160 FVYINEYRVGEGITLNQVA---VGCECQD-CLlapTGGCCPGASLHKFAYNDQGqvRLKAG----QP--IYECNSRCCCG 229
Cdd:cd10543   3 FLYVTENCETSPLNIDRNItslQTCSCRDdCS---SDNCVCGRLSVRCWYDKEG--RLLPDfnklDPplIFECNRACSCW 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  230 YDCPNRVVQKGIRYDLCIFRTNdGRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRgqiydrQGATYLFDLDYVE-DVY 308
Cdd:cd10543  78 RNCRNRVVQNGIRYRLQLFRTR-GMGWGVRALQDIPKGTFVCEYIGELISDSEADSR------EDDSYLFDLDNKDgETY 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  309 TVDAAYYGNISHFVNHSCDPNLQVYNVFIDNLDERLPRIAFFATRTIWAGEELTFDYNMQVDPVdmestrmdsnfglagl 388
Cdd:cd10543 151 CIDARRYGNISRFINHLCEPNLIPVRVFVEHQDLRFPRIAFFASRDIKAGEELGFDYGEKFWRI---------------- 214

                       250       260
                ....*....|....*....|
gi 6755702  389 pgspkKRVRIECKCGTTACR 408
Cdd:cd10543 215 -----KGKYFTCRCGSPKCK 229
SET_SETMAR cd10544
SET domain (including pre-SET and post-SET domains) found in SET domain and mariner ...
 180-411 6.78e-54

SET domain (including pre-SET and post-SET domains) found in SET domain and mariner transposase fusion protein (SETMAR) and similar proteins; SETMAR (also termed metnase) is a DNA-binding protein that is indirectly recruited to sites of DNA damage through protein-protein interactions. It has a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity. SETMAR also acts as a histone-lysine N-methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3. It specifically mediates dimethylation of H3 'Lys-36' at sites of DNA double-strand break and may recruit proteins required for efficient DSB repair through non-homologous end-joining.


Pssm-ID: 380942 [Multi-domain]  Cd Length: 254  Bit Score: 179.42  E-value: 6.78e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  180 GCECQDCLLAPTGGCCpgasLHKF--AYNDQGQVRL---KAGQPIYECNSRCCCGYDCPNRVVQKGIRYDLCIFRTnDGR 254
Cdd:cd10544  26 GCDCKTSSCEPETCSC----LRKYgpNYDDDGCLLDfdgKYSGPVFECNSMCKCSESCQNRVVQNGLQFKLQVFKT-PKK 100

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  255 GWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGATYLFDLDyvEDVYT-------VDAAYYGNISHFVNHSCD 327
Cdd:cd10544 101 GWGLRTLEFIPKGRFVCEYAGEVIGFEEARRRTKSQTKGDMNYIIVLR--EHLSSgkvletfVDPTYIGNIGRFLNHSCE 178

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  328 PNLQVYNVFIDNLderLPRIAFFATRTIWAGEELTFDYNMQVDPVDMESTrmdsnfglAGLPGSPKKRVriECKCGTTAC 407
Cdd:cd10544 179 PNLFMVPVRVDSM---VPKLALFAARDIVAGEELSFDYSGEFSNSVESVT--------LARQDESKSRK--PCLCGAENC 245


                ....
gi 6755702  408 RKYL 411
Cdd:cd10544 246 RGFL 249
SET_AtSUVH-like cd10545
SET domain found in Arabidopsis thaliana histone H3-K9 methyltransferases (SUVHs) and similar ...
 159-366 3.35e-52

SET domain found in Arabidopsis thaliana histone H3-K9 methyltransferases (SUVHs) and similar proteins; Arabidopsis thaliana SUVH protein (also termed suppressor of variegation 3-9 homolog protein) is a histone-lysine N-methyltransferase that methylates 'Lys-9' of histone H3. H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression. Some family members contain a post-SET domain which binds a Zn2+ ion. Most family members, except for Arabidopsis thaliana SUVH9, contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380943 [Multi-domain]  Cd Length: 232  Bit Score: 174.51  E-value: 3.35e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  159 SFVYINEYRVGEGITLNQVAVGCECQD-CLLAPTGGCCPGASLHKFAYNDQGqvRLKAGQP-IYECNSRCCCGYDCPNRV 236
Cdd:cd10545   2 GFTYTVKLIIPPGVSLPVPSTGCDCKNrCTDGASDCACVKKNGGEIPYNFNG--RLIRAKPaIYECGPLCKCPPSCYNRV 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  237 VQKGIRYDLCIFRTNDgRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDrqgatYLFDLDYVEDV--------- 307
Cdd:cd10545  80 TQKGLRYRLEVFKTAE-RGWGVRSWDSIPAGSFICEYVGELLDTSEADTRSGNDD-----YLFDIDNRQTNrgwdggqrl 153

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6755702  308 -------------------YTVDAAYYGNISHFVNHSCDPNLQVYNVFIDNLDERLPRIAFFATRTIWAGEELTFDYN 366
Cdd:cd10545 154 dvgmsdgerssaedeesseFTIDAGSFGNVARFINHSCSPNLFVQCVLYDHNDLRLPRVMLFAADNIPPLQELTYDYG 231
SET_EHMT1 cd10535
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 219-365 6.54e-47

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins; EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, or lysine N-methyltransferase 1D (KMT1D)) acts as a histone-lysine N-methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380933 [Multi-domain]  Cd Length: 231  Bit Score: 160.48  E-value: 6.54e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  219 IYECNSRCCCGYDCPNRVVQKGIRYDLCIFRTNDgRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRgqiydrQGATYL 298
Cdd:cd10535  67 IFECNHACSCWRNCRNRVVQNGLRARLQLYRTRD-MGWGVRSLQDIPPGTFVCEYVGELISDSEADVR------EEDSYL 139

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6755702  299 FDLDYVE-DVYTVDAAYYGNISHFVNHSCDPNLQVYNVFIDNLDERLPRIAFFATRTIWAGEELTFDY 365
Cdd:cd10535 140 FDLDNKDgEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDY 207
SET_EHMT2 cd10533
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 219-365 1.43e-43

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 2 (EHMT2) and similar proteins; EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C (KMT1C), or protein G9a) acts as a histone-lysine N-methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380931 [Multi-domain]  Cd Length: 239  Bit Score: 152.09  E-value: 1.43e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  219 IYECNSRCCCGYDCPNRVVQKGIRYDLCIFRTNDgRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRgqiydrQGATYL 298
Cdd:cd10533  67 IFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAK-MGWGVRALQTIPQGTFICEYVGELISDAEADVR------EDDSYL 139

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6755702  299 FDLDYVE-DVYTVDAAYYGNISHFVNHSCDPNLQVYNVFIDNLDERLPRIAFFATRTIWAGEELTFDY 365
Cdd:cd10533 140 FDLDNKDgEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDY 207
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 243-366 9.66e-42

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 143.24  E-value: 9.66e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702     243 YDLCIFRTnDGRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGA--TYLFDLDyveDVYTVDAAYYGNISH 320
Cdd:smart00317   1 NKLEVFKS-PGKGWGVRATEDIPKGEFIGEYVGEIITSEEAEERPKAYDTDGAkaFYLFDID---SDLCIDARRKGNLAR 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 6755702     321 FVNHSCDPNLQVYNVFIDNLDerlpRIAFFATRTIWAGEELTFDYN 366
Cdd:smart00317  77 FINHSCEPNCELLFVEVNGDD----RIVIFALRDIKPGEELTIDYG 118
SET_SETDB cd10541
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1), ...
 172-411 8.86e-41

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1), SET domain bifurcated 2 (SETDB2), and similar proteins; SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis.


Pssm-ID: 380939 [Multi-domain]  Cd Length: 236  Bit Score: 144.61  E-value: 8.86e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  172 ITLNQVAVGCECQD---------C--LLAPTGGCCPGASLHKFAYNDQGQVRLKAGQPIYECNSRCCCGYD-CPNRVVQK 239
Cdd:cd10541   9 ISYGKFLVGCDCTDgcrdkskcaChqLTIQATACTPGGQDNPTAGYQYKRLEECLPTGVYECNKLCKCDPNmCQNRLVQH 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  240 GIRYDLCIFRTNDgRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIydrQGATYLFDLDYVED-VYTVDAAYYGNI 318
Cdd:cd10541  89 GLQVRLQLFKTQN-KGWGIRCLDDIAKGTFVCIYAGKILTDDFADKEGLE---MGDEYFANLDHIEEsCYIIDAKLEGNL 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  319 SHFVNHSCDPNLQVYNVFIDNLDERLPRIAFFATRTIWAGEELTFDYNMQVDPVdmestrmdsnfglaglpgsPKKrvRI 398
Cdd:cd10541 165 GRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASKRIKAGTELTWDYNYEVGSV-------------------EGK--EL 223

                       250
                ....*....|...
gi 6755702  399 ECKCGTTACRKYL 411
Cdd:cd10541 224 LCCCGSNECRGRL 236
SET_EZH cd10519
SET domain found in enhancer of zeste homolog 1 (EZH1), zeste homolog 2 (EZH2) and similar ...
 255-365 1.06e-35

SET domain found in enhancer of zeste homolog 1 (EZH1), zeste homolog 2 (EZH2) and similar proteins; The family includes EZH1 and EZH2. EZH1 (EC 2.1.1.43; also termed ENX-2, or histone-lysine N-methyltransferase EZH1) is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. EZH2 (EC 2.1.1.43; also termed lysine N-methyltransferase 6, ENX-1, or histone-lysine N-methyltransferase EZH2) is a catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Both, EZH1 and EZH2, can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively.


Pssm-ID: 380917  Cd Length: 117  Bit Score: 127.36  E-value: 1.06e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  255 GWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGATYLFDLDyveDVYTVDAAYYGNISHFVNHSCDPNLQVyN 334
Cdd:cd10519  12 GWGLFLKEPIKKDEFIGEYTGELISQDEADRRGKIYDKYNSSYLFNLN---DQFVVDATRKGNKIRFANHSSNPNCYA-K 87

                        90       100       110
                ....*....|....*....|....*....|.
gi 6755702  335 VFIDNLDErlpRIAFFATRTIWAGEELTFDY 365
Cdd:cd10519  88 VMMVNGDH---RIGIFAKRDIEAGEELFFDY 115
SET_SETD2 cd19172
SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and ...
 247-411 1.38e-34

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and similar proteins; SETD2 (also termed HIF-1, huntingtin yeast partner B, huntingtin-interacting protein 1 (HIP-1), huntingtin-interacting protein B, lysine N-methyltransferase 3A or protein-lysine N-methyltransferase SETD2) acts as histone-lysine N-methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. It has been shown that methylation is a posttranslational modification of dynamic microtubules and that SETD2 methylates alpha-tubulin at lysine 40, the same lysine that is marked by acetylation on microtubules. Methylation of microtubules occurs during mitosis and cytokinesis and can be ablated by SETD2 deletion, which causes mitotic spindle and cytokinesis defects, micronuclei, and polyploidy.


Pssm-ID: 380949 [Multi-domain]  Cd Length: 142  Bit Score: 125.00  E-value: 1.38e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  247 IFRTnDGRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGAT--YLFDLDYVEdvyTVDAAYYGNISHFVNH 324
Cdd:cd19172   6 VFRT-EKKGWGLRAAEDLPKGTFVIEYVGEVLDEKEFKRRMKEYAREGNRhyYFMALKSDE---IIDATKKGNLSRFINH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  325 SCDPN--LQVYNVfidnldERLPRIAFFATRTIWAGEELTFDYNMQVdpvdmestrmdsnFGlaglpGSPKKrvrieCKC 402
Cdd:cd19172  82 SCEPNceTQKWTV------NGELRVGFFAKRDIPAGEELTFDYQFER-------------YG-----KEAQK-----CYC 132


                ....*....
gi 6755702  403 GTTACRKYL 411
Cdd:cd19172 133 GSPNCRGYI 141
SET_SETD2-like cd10531
SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), ...
 244-408 4.64e-34

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2), ASH1-like protein (ASH1L) and similar proteins; This family includes SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2) and ASH1-like protein (ASH1L), which function as histone-lysine N-methyltransferases. SETD2 specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. NSD2 shows histone H3 'Lys-27' (H3K27me) methyltransferase activity. ASH1L specifically methylates 'Lys-36' of histone H3 (H3K36me). The family also includes Arabidopsis thaliana ASH1-related protein 3 (ASHR3) and similar proteins.


Pssm-ID: 380929  Cd Length: 136  Bit Score: 123.52  E-value: 4.64e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  244 DLCIFRTNDgRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRgQIYDRQGATYLFDLDYVEDVYTVDAAYYGNISHFVN 323
Cdd:cd10531   1 KLELFRTEK-KGWGVKAKEDIQKGEFIIEYVGEVIDKKEFKER-LDEYEELGKSNFYILSLSDDVVIDATRKGNLSRFIN 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  324 HSCDPNL--QVYNVFIDnlderlPRIAFFATRTIWAGEELTFDYNMQvdpvdmestrmdsNFGLAGlpgspkkrvrIECK 401
Cdd:cd10531  79 HSCEPNCetQKWIVNGE------YRIGIFALRDIPAGEELTFDYNFV-------------NYNEAK----------QVCL 129


                ....*..
gi 6755702  402 CGTTACR 408
Cdd:cd10531 130 CGAQNCR 136
SET_ASH1L cd19174
SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ...
 248-411 5.08e-33

SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ASH1L (EC 2.1.1.43; also termed absent small and homeotic disks protein 1 homolog, KMT2H, or lysine N-methyltransferase 2H) acts as histone-lysine N-methyltransferase that specifically methylates 'Lys-36' of histone H3 (H3K36me). It plays important roles in development; heterozygous mutation of ASH1L is associated with severe intellectual disability (ID) and multiple congenital anomaly (MCA).


Pssm-ID: 380951 [Multi-domain]  Cd Length: 141  Bit Score: 120.86  E-value: 5.08e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  248 FRTNDgRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRG-QIYDRQGATYLFDLDYVEdvyTVDAAYYGNISHFVNHSC 326
Cdd:cd19174   5 FRTED-KGWGVRTKEPIKAGQFIIEYVGEVVSEQEFRRRMiEQYHNHSHHYCLNLDSGM---VIDGYRMGNEARFVNHSC 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  327 DPN--LQVYNVfidnldERLPRIAFFATRTIWAGEELTFDYNMqvDPVDMESTRmdsnfglaglpgspkkrvriECKCGT 404
Cdd:cd19174  81 DPNceMQKWSV------NGVYRIGLFALKDIPAGEELTYDYNF--HSFNVEKQQ--------------------PCKCGS 132


                ....*..
gi 6755702  405 TACRKYL 411
Cdd:cd19174 133 PNCRGVI 139
SET_SETD1-like cd10518
SET domain (including post-SET domain) found in SET domain-containing proteins (SETD1A/SETD1B), ...
 255-408 4.26e-32

SET domain (including post-SET domain) found in SET domain-containing proteins (SETD1A/SETD1B), histone-lysine N-methyltransferases (KMT2A/KMT2B/KMT2C/KMT2D) and similar proteins; This family includes SET domain-containing protein 1A (SETD1A), 1B (SETD1B), as well as histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B), 2C (KMT2C), 2D (KMT2D). These proteins are histone-lysine N-methyltransferases (EC 2.1.1.43) that specifically methylate 'Lys-4' of histone H3 (H3K4me).


Pssm-ID: 380916  Cd Length: 150  Bit Score: 118.85  E-value: 4.26e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  255 GWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGA--TYLFDLDyveDVYTVDAAYYGNISHFVNHSCDPNLQV 332
Cdd:cd10518  25 GWGLFAKRPIAAGEMVIEYVGEVIRPIVADKREKRYDEEGGggTYMFRID---EDLVIDATKKGNIARFINHSCDPNCYA 101

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6755702  333 YNVFIDNLDerlpRIAFFATRTIWAGEELTFDYNMQVDPVDmestrmdsnfglaglpgspkkrvRIECKCGTTACR 408
Cdd:cd10518 102 KIITVDGEK----HIVIFAKRDIAPGEELTYDYKFPIEDEE-----------------------KIPCLCGAPNCR 150
SET_SETDB2 cd10523
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 2 (SETDB2) ...
 219-411 1.42e-31

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 2 (SETDB2) and similar proteins; SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis.


Pssm-ID: 380921 [Multi-domain]  Cd Length: 266  Bit Score: 121.09  E-value: 1.42e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  219 IYECNSRCCCGYD-CPNRVVQKGIRYDLCIFRTNDgRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQG--- 294
Cdd:cd10523  83 LYECNVSCKCNRMlCQNRVVQHGLQVRLQVFKTEK-KGWGVRCLDDIDKGTFVCIYAGRVLSRARSPTEPLPPKLELpse 161

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  295 --------ATYLFDLDYVED-VYTVDAAYYGNISHFVNHSCDPNLQVYNVFIDNLDERLPRIAFFATRTIWAGEELTFDY 365
Cdd:cd10523 162 nevevvtsWLILSKKRKLREnVCFLDASKEGNVGRFLNHSCCPNLFVQNVFVDTHDKNFPWVAFFTNRVVKAGTELTWDY 241

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 6755702  366 NMQvdpvdmestrmdsnfglaglPGS-PKKrvRIECKCGTTACRKYL 411
Cdd:cd10523 242 SYD--------------------AGTsPEQ--EIPCLCGVNKCQKKI 266
CD_SUV39H1_like cd18639
chromodomain of histone methyltransferase SUV39H1, and similar proteins; CHRomatin ...
 43-91 2.13e-29

chromodomain of histone methyltransferase SUV39H1, and similar proteins; CHRomatin Organization Modifier (chromo) domain of human SUV39H1, a histone lysine methyltransferase (HMT) which catalyzes di- and tri-methylation of lysine 9 of histone H3 (H3K9me2/3), leading to heterochromatin formation and gene silencing. H3K9me2/3 represents a specific mark for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3, and/or CBX5) proteins to methylated histones. SUV39H1 mainly functions in heterochromatin regions. The human SUV39H1/2, histone H3K9 methyltransferases, are the mammalian homologs of Drosophila Su(var)3-9 and Schizosaccharomyces pombe Clr4. SUV39H1 contains a chromodomain at its N-terminus and a SET domain at its C-terminus. Although the SET domain performs the catalytic activity, the chromodomain of SUV39H1 is essential for the catalytic activity of SUV39H1. A chromodomain is a conserved region of about 50 amino acids, found in a variety of chromosomal proteins, and which appears to play a role in the functional organization of the eukaryotic nucleus. The chromodomain is implicated in the binding, of the proteins in which it is found, to methylated histone tails and maybe RNA. A chromodomain may occur as a single instance, in a tandem arrangement, or followed by a related chromo shadow domain.


Pssm-ID: 349289  Cd Length: 49  Bit Score: 108.37  E-value: 2.13e-29
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 6755702   43 FEVEYLCDYKKIREQEYYLVKWRGYPDSENTWEPRQNLKCIRVLKQFHK 91
Cdd:cd18639   1 YEVEYLCDYKKIREQEYYLVKWKGYPDSENTWEPRQNLKCSRLLKQFHK 49
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 255-366 2.53e-29

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 110.31  E-value: 2.53e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702    255 GWGVRTLEKIRKNSFVMEYVGE-IITSEEAERRGQIY-----DRQGATYLFDLDyVEDVYTVD--AAYYGNISHFVNHSC 326
Cdd:pfam00856   1 GRGLFATEDIPKGEFIGEYVEVlLITKEEADKRELLYydkleLRLWGPYLFTLD-EDSEYCIDarALYYGNWARFINHSC 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 6755702    327 DPNLQVYNVFIDnldeRLPRIAFFATRTIWAGEELTFDYN 366
Cdd:pfam00856  80 DPNCEVRVVYVN----GGPRIVIFALRDIKPGEELTIDYG 115
SET_NSD cd19173
SET domain (including post-SET domain) found in nuclear SET domain-containing proteins, NSD1, ...
 247-367 8.25e-28

SET domain (including post-SET domain) found in nuclear SET domain-containing proteins, NSD1, NSD2, NSD3 and similar proteins; The nuclear receptor-binding SET Domain (NSD) family of histone H3 lysine 36 methyltransferases is comprised of NSD1, NSD2, and NSD3, which are primarily known to be involved in chromatin integrity and gene expression through mono-, di-, or tri-methylating lysine 36 of histone H3 (H3K36), respectively. NSD1 (EC 2.1.1.43; also termed histone-lysine N-methyltransferase H3 lysine-36 and H4 lysine-20 specific, androgen receptor coactivator 267 kDa protein (ARA267), androgen receptor-associated protein of 267 kDa, H3-K36-HMTase, H4-K20-HMTase, lysine N-methyltransferase 3B (KMT3B) or NR-binding SET domain-containing protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4. NSD2 (EC 2.1.1.43; also termed multiple myeloma SET domain-containing protein (MMSET), protein trithorax-5 (TRX5), or wolf-Hirschhorn syndrome candidate 1 protein (WHSC1)) acts as histone-lysine N-methyltransferase with histone H3 'Lys-27' (H3K27me) methyltransferase activity. NSD3 (EC 2.1.1.43; also termed protein whistle, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, Wolf-Hirschhorn syndrome candidate 1-like protein 1 (WHSC1L1), or WHSC1-like protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-4' and 'Lys-27' of histone H3.


Pssm-ID: 380950 [Multi-domain]  Cd Length: 142  Bit Score: 107.02  E-value: 8.25e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  247 IFRTNDgRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGAT--YLFDLDyvEDVYtVDAAYYGNISHFVNH 324
Cdd:cd19173   6 PFKTGD-RGWGLRTKRDIKKGDFVIEYVGELIDEEECRRRLKKAHENNITnfYMLTLD--KDRI-IDAGPKGNLSRFMNH 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 6755702  325 SCDPNL--QVYNVFIDnlderlPRIAFFATRTIWAGEELTFDYNM 367
Cdd:cd19173  82 SCQPNCetQKWTVNGD------TRVGLFAVRDIPAGEELTFNYNL 120
SET_ASHR3-like cd19175
SET domain (including post-SET domain) found in Arabidopsis thaliana ASH1-related protein 3 ...
 255-411 2.10e-27

SET domain (including post-SET domain) found in Arabidopsis thaliana ASH1-related protein 3 (ASHR3) and similar proteins; This family includes Arabidopsis thaliana ASH1-related protein 3 (ASHR3, also termed protein SET DOMAIN GROUP 4 or protein stamen loss), ASH1 homolog 3 (ASHH3, also termed protein SET DOMAIN GROUP 7) and homolog 4 (ASHH4, also termed protein SET DOMAIN GROUP 24). They all function as histone-lysine N-methyltransferases (EC 2.1.1.43).


Pssm-ID: 380952 [Multi-domain]  Cd Length: 139  Bit Score: 105.96  E-value: 2.10e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  255 GWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGATYLFDLDYVEDVyTVDAAYYGNISHFVNHSCDPNLQVYN 334
Cdd:cd19175  11 GWGLVADEDINAGEFIIEYVGEVIDDKTCEERLWDMKHKGEKNFYMCEIDKDM-VIDATFKGNLSRFINHSCDPNCELQK 89

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6755702  335 VFIDNLDerlpRIAFFATRTIWAGEELTFDYNMqvdpvdmestrmdSNFGLAglpgspkkrvrIECKCGTTACRKYL 411
Cdd:cd19175  90 WQVDGET----RIGVFAIRDIKKGEELTYDYQF-------------VQFGAD-----------QDCHCGSKNCRGKL 138
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
249-375 2.47e-27

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 105.43  E-value: 2.47e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  249 RTNDGRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIyDRQGATYLFDLDyveDVYTVDAAYYGNISHFVNHSCDP 328
Cdd:COG2940  11 RPSPIHGRGVFATRDIPKGTLIGEYPGEVITWAEAERREPH-KEPLHTYLFELD---DDGVIDGALGGNPARFINHSCDP 86

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 6755702  329 NLQvynvfidnLDERLPRIAFFATRTIWAGEELTFDYNMQVDPVDME 375
Cdd:COG2940  87 NCE--------ADEEDGRIFIVALRDIAAGEELTYDYGLDYDEEEYP 125
SET_EZH2 cd19218
SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins; EZH2 (EC 2.1.1.43) ...
 251-365 2.19e-25

SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins; EZH2 (EC 2.1.1.43), also termed lysine N-methyltransferase 6, or ENX-1, or histone-lysine N-methyltransferase EZH2, is a catalytic subunit of the polycomb repressive complex 2 (PRC2)/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. It can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. PRC2 is involved in several cancers; EZH2 is overexpressed in breast, liver and prostate cancer, while point mutations in EZH2 alter the substrate preference and product specificity of PRC2 in Non-Hodgkin lymphomas (NHLs). Thus, PRC2 is a popular target for cancer therapeutics.


Pssm-ID: 380995  Cd Length: 120  Bit Score: 99.60  E-value: 2.19e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  251 NDGRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGATYLFDLDyveDVYTVDAAYYGNISHFVNHSCDPNL 330
Cdd:cd19218  11 SDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLN---NDFVVDATRKGNKIRFANHSVNPNC 87

                        90       100       110
                ....*....|....*....|....*....|....*
gi 6755702  331 QVyNVFIDNLDErlpRIAFFATRTIWAGEELTFDY 365
Cdd:cd19218  88 YA-KVMMVNGDH---RIGIFAKRAIQTGEELFFDY 118
PreSET smart00468
N-terminal to some SET domains; A Cys-rich putative Zn2+-binding domain that occurs N-terminal ...
 132-227 2.81e-24

N-terminal to some SET domains; A Cys-rich putative Zn2+-binding domain that occurs N-terminal to some SET domains. Function is unknown. Unpublished.


Pssm-ID: 128744 [Multi-domain]  Cd Length: 98  Bit Score: 95.95  E-value: 2.81e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702     132 EQELNAKRSHLGRITVeNEVDLDGPPRSFVYINEYRVGEGIT---LNQVAVGCECQ-DCLLAPTGgCCPGASLHKFAYND 207
Cdd:smart00468   1 CLDISNGKENVPVPLV-NEVDEDPPPPDFEYISEYIYGQGVPidrSPSPLVGCSCSgDCSSSNKC-ECARKNGGEFAYEL 78

                           90       100
                   ....*....|....*....|
gi 6755702     208 QGQVRLKAGQPIYECNSRCC 227
Cdd:smart00468  79 NGGLRLKRKPLIYECNSRCS 98
SET_LegAS4-like cd10522
SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and ...
 255-366 3.68e-24

SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and similar proteins; LegAS4 is a type IV secretion system effector of Legionella pneumophila. It contains a SET domain that is involved in the modification of Lys4 of histone H3 (H3K4) in the nucleolus of the host cell, thereby enhancing heterochromatic rDNA transcription. It also contains an ankyrin repeat domain of unknown function at its C-terminal region.


Pssm-ID: 380920 [Multi-domain]  Cd Length: 122  Bit Score: 96.64  E-value: 3.68e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  255 GWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQiyDRQGATYLFDLDYveDVYTVDAAYYGNISHFVNHSCDPNLQVYN 334
Cdd:cd10522  14 GLGLFAAETIAKGEFVGEYTGEVLDRWEEDRDSV--YHYDPLYPFDLNG--DILVIDAGKKGNLTRFINHSDQPNLELIV 89

                        90       100       110
                ....*....|....*....|....*....|..
gi 6755702  335 VFidnlDERLPRIAFFATRTIWAGEELTFDYN 366
Cdd:cd10522  90 RT----LKGEQHIGFVAIRDIKPGEELFISYG 117
SET_EZH1 cd19217
SET domain found in enhancer of zeste homolog 1 (EZH1) and similar proteins; EZH1 (EC 2.1.1.43) ...
 238-365 3.87e-24

SET domain found in enhancer of zeste homolog 1 (EZH1) and similar proteins; EZH1 (EC 2.1.1.43), also termed ENX-2, or histone-lysine N-methyltransferase EZH1, is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. It can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively.


Pssm-ID: 380994  Cd Length: 136  Bit Score: 97.06  E-value: 3.87e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  238 QKGIRYDLcIFRTNDGRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGATYLFDLDyveDVYTVDAAYYGN 317
Cdd:cd19217   1 QRGLKKHL-LLAPSDVAGWGTFIKESVQKNEFISEYCGELISQDEADRRGKVYDKYMSSFLFNLN---NDFVVDATRKGN 76

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 6755702  318 ISHFVNHSCDPNLQVYNVFIdNLDErlpRIAFFATRTIWAGEELTFDY 365
Cdd:cd19217  77 KIRFANHSVNPNCYAKVVMV-NGDH---RIGIFAKRAIQQGEELFFDY 120
SET_KMT2A_2B cd19170
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), ...
 255-411 4.15e-24

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B) and similar proteins; This family includes KMT2A and KMT2B. Both KMT2A (also termed ALL-1 or CXXC7 or MLL or MLL1 or TRX1 or HRX) and KMT2B (also termed MLL4 or TRX2) act as histone methyltransferases that methylate 'Lys-4' of histone H3 (H3K4me).


Pssm-ID: 380947 [Multi-domain]  Cd Length: 152  Bit Score: 97.46  E-value: 4.15e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  255 GWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQG-ATYLFDLDyveDVYTVDAAYYGNISHFVNHSCDPNLQVY 333
Cdd:cd19170  25 GRGLFCKRNIDAGEMVIEYAGEVIRSVLTDKREKYYESKGiGCYMFRID---DDEVVDATMHGNAARFINHSCEPNCYSR 101

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6755702  334 NVFIDNLDerlpRIAFFATRTIWAGEELTFDYNMqvdpvdmestrmdsnfglaglpgsPKKRVRIECKCGTTACRKYL 411
Cdd:cd19170 102 VVNIDGKK----HIVIFALRRILRGEELTYDYKF------------------------PIEDVKIPCTCGSKKCRKYL 151
SET_SET1 cd20072
SET domain (including post-SET domain) found in catalytic component of the Saccharomyces ...
 256-408 9.83e-24

SET domain (including post-SET domain) found in catalytic component of the Saccharomyces cerevisiae COMPASS complex and similar proteins; The family contains mostly fungal SET domains, including SET1 found in the catalytic component of the Saccharomyces cerevisiae COMPASS (complex of proteins associated with Set1). SET1 is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me), when part of the SET1 histone methyltransferase (HMT) complex. The activity of this catalytic domain is established through forming a complex with a set of core proteins; it is extensively contacted by Cps60 (Bre2), Cps50 (Swd1), and Cps30 (Swd3).


Pssm-ID: 380998  Cd Length: 148  Bit Score: 96.34  E-value: 9.83e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  256 WGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQG--ATYLFDLDyveDVYTVDAAYYGNISHFVNHSCDPNLQVY 333
Cdd:cd20072  25 WGLYAMENISAKDMVIEYVGEVIRQQVADEREKRYLRQGigSSYLFRID---DDTVVDATKKGNIARFINHCCDPNCTAK 101

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6755702  334 NVFIDNldERlpRIAFFATRTIWAGEELTFDYNMQVDpvdmestrmdsnfglaglpgspkkRVRIECKCGTTACR 408
Cdd:cd20072 102 IIKVEG--EK--RIVIYAKRDIAAGEELTYDYKFPRE------------------------EDKIPCLCGAPNCR 148
SET_KMT2C_2D cd19171
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), ...
 255-411 2.32e-23

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins; This family includes KMT2C and KMT2D. Both, KMT2C (also termed HALR or MLL3) and KMT2D (also termed ALR or MLL2), act as histone methyltransferases that methylate 'Lys-4' of histone H3 (H3K4me). They are subunits of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation.


Pssm-ID: 380948 [Multi-domain]  Cd Length: 153  Bit Score: 95.19  E-value: 2.32e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  255 GWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQG-ATYLFDLDyveDVYTVDAAYYGNISHFVNHSCDPNL--Q 331
Cdd:cd19171  25 GLGLYAARDIEKHTMVIEYIGEIIRNEVANRREKIYESQNrGIYMFRID---NDWVIDATMTGGPARYINHSCNPNCvaE 101

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  332 VYNVfidnldERLPRIAFFATRTIWAGEELTFDYNMqvdpvDMEStrmDSNfglaglpgspkkrvRIECKCGTTACRKYL 411
Cdd:cd19171 102 VVTF------DKEKKIIIISNRRIAKGEELTYDYKF-----DFED---DQH--------------KIPCLCGAPNCRKWM 153
SET_SETD1 cd19169
SET domain (including post-SET domain) found in SET domain-containing protein 1 (SETD1) and ...
 255-408 4.30e-23

SET domain (including post-SET domain) found in SET domain-containing protein 1 (SETD1) and similar proteins; This family includes SET domain-containing protein 1A (SETD1A) and SET domain-containing protein 1B (SETD1B). These proteins are histone-lysine N-methyltransferases that specifically methylate 'Lys-4' of histone H3 (H3K4me) when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated.


Pssm-ID: 380946  Cd Length: 148  Bit Score: 94.33  E-value: 4.30e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  255 GWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQ--GATYLFDLDyveDVYTVDAAYYGNISHFVNHSCDPNL-- 330
Cdd:cd19169  24 DWGLFALEPIAADEMVIEYVGQVIRQSVADEREKRYEAIgiGSSYLFRVD---DDTIIDATKCGNLARFINHSCNPNCya 100

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6755702  331 QVYNVfidnldERLPRIAFFATRTIWAGEELTFDYNMqvdpvdmestrmdsnfglaglpgsPKKRVRIECKCGTTACR 408
Cdd:cd19169 101 KIITV------ESQKKIVIYSKRPIAVNEEITYDYKF------------------------PIEDEKIPCLCGAPQCR 148
Pre-SET pfam05033
Pre-SET motif; This protein motif is a zinc binding motif. It contains 9 conserved cysteines ...
 136-235 1.20e-22

Pre-SET motif; This protein motif is a zinc binding motif. It contains 9 conserved cysteines that coordinate three zinc ions. It is thought that this region plays a structural role in stabilising SET domains.


Pssm-ID: 461530 [Multi-domain]  Cd Length: 99  Bit Score: 91.71  E-value: 1.20e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702    136 NAKRSHLGRITVENEVDLDGPPRSFVYINEYRVGEGITLNQvAVGCECQDCLlaPTGGCCPGASLH--KFAYNDQGQVRL 213
Cdd:pfam05033   1 ISKGKENVPIPVVNEVDDEPPPPDFTYITSYIYPKEFLLII-PQGCDCGDCS--SEKCSCAQLNGGefRFPYDKDGLLVP 77

                          90       100
                  ....*....|....*....|..
gi 6755702    214 KAGQPIYECNSRCCCGYDCPNR 235
Cdd:pfam05033  78 ESKPPIYECNPLCGCPPSCPNR 99
SET_EZH-like cd19168
SET domain found in enhancer of zeste homolog 1 (EZH1) and zeste homolog 2 (EZH2) of polycomb ...
 255-365 1.79e-21

SET domain found in enhancer of zeste homolog 1 (EZH1) and zeste homolog 2 (EZH2) of polycomb repressive complex 2 (PRC2), and similar proteins; The family includes EZH1 and EZH2. EZH1 (EC 2.1.1.43; also termed ENX-2, or histone-lysine N-methyltransferase EZH1) is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. EZH2 (EC 2.1.1.43; also termed lysine N-methyltransferase 6, ENX-1, or histone-lysine N-methyltransferase EZH2) is a catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Both EZH1 and EZH2 can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. PRC2 is involved in several cancers; EZH2 is overexpressed in breast, liver and prostate cancer, while point mutations in EZH2 alter the substrate preference and product specificity of PRC2 in Non-Hodgkin lymphomas (NHLs). Thus, PRC2 is a popular target for cancer therapeutics.


Pssm-ID: 380945  Cd Length: 124  Bit Score: 89.17  E-value: 1.79e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  255 GWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGATYLFDLDyveDVYTVDAAYYGNISHFVNHSCDP----NL 330
Cdd:cd19168  13 GLGLFAAEDIKEGEFVIEYTGELISHDEGVRREHRRGDVSYLYLFEEQ---EGIWVDAAIYGNLSRYINHATDKvktgNC 89

                        90       100       110
                ....*....|....*....|....*....|....*
gi 6755702  331 QVYNVFidnlDERLPRIAFFATRTIWAGEELTFDY 365
Cdd:cd19168  90 MPKIMY----VNHEWRIKFTAIKDIKIGEELFFNY 120
SET_NSD3 cd19212
SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing ...
 247-411 3.55e-21

SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 3 (NSD3) and similar proteins; NSD3 (EC 2.1.1.43; also termed protein whistle, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, Wolf-Hirschhorn syndrome candidate 1-like protein 1 (WHSC1L1), or WHSC1-like protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. NSD3 is amplified and overexpressed in multiple cancer types, including acute myeloid leukemia (AML), breast, lung, pancreatic and bladder cancers, as well as squamous cell carcinoma of the head and neck (SCCHN). NSD3 contributes to tumorigenesis by interacting with bromodomain-containing protein 4 (BRD4), the bromodomain and extraterminal (BET) protein, which is a potential therapeutic target in acute myeloid leukemia (AML). NSD3 is amplified in primary tumors and cell lines from breast carcinoma, and can promote the cell viability of small-cell lung cancer and pancreatic ductal adenocarcinoma. High NSD3 expression is implicated in poor grade and heavy smoking history in SCCHN. Thus, NSD3 may serve as a potential druggable target for selective cancer therapy.


Pssm-ID: 380989 [Multi-domain]  Cd Length: 142  Bit Score: 88.83  E-value: 3.55e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  247 IFRTnDGRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGATYLFDLDYVEDvYTVDAAYYGNISHFVNHSC 326
Cdd:cd19212   6 IIKT-ERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKD-RIIDAGPKGNYSRFMNHSC 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  327 DPN--LQVYNVFIDNlderlpRIAFFATRTIWAGEELTFDYNMQVdpvdmestrmdsnFGLAglpgspkkrvRIECKCGT 404
Cdd:cd19212  84 NPNceTQKWTVNGDV------RVGLFALCDIPAGMELTFNYNLDC-------------LGNG----------RTECHCGA 134


                ....*..
gi 6755702  405 TACRKYL 411
Cdd:cd19212 135 DNCSGFL 141
SET_NSD2 cd19211
SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) ...
 247-411 4.17e-20

SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins; NSD2 (EC 2.1.1.43; also termed multiple myeloma SET domain-containing protein (MMSET), protein trithorax-5 (TRX5), or wolf-Hirschhorn syndrome candidate 1 protein (WHSC1)) acts as histone-lysine N-methyltransferase with histone H3 'Lys-36' (H3K36me) methyltransferase activity. NSD2 has been shown to mediate di- and trimethylation of H3K36 and dimethylation of H4K20 in different systems, and has been characterized as a transcriptional repressor interacting with histone deacetylase HDAC1 and histone demethylase LSD1. NSD2 mediates constitutive NF-kappaB signaling for cancer cell proliferation, survival and tumor growth. It is highly overexpressed in several types of human cancers, including small-cell lung cancers, neuroblastoma, carcinomas of stomach and colon, and bladder cancers, and its overexpression tends to be associated with tumor aggressiveness. WHSC1 is frequently deleted in Wolf-Hirschhorn syndrome (WHS).


Pssm-ID: 380988 [Multi-domain]  Cd Length: 142  Bit Score: 85.81  E-value: 4.17e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  247 IFRTnDGRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGATYLFDLDYVEDvYTVDAAYYGNISHFVNHSC 326
Cdd:cd19211   6 IIKT-EGKGWGLIAKRDIKKGEFVNEYVGELIDEEECMARIKHAHENDITHFYMLTIDKD-RIIDAGPKGNYSRFMNHSC 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  327 DPN--LQVYNVFIDNlderlpRIAFFATRTIWAGEELTFDYNMqvDPVDMESTRmdsnfglaglpgspkkrvrieCKCGT 404
Cdd:cd19211  84 QPNceTQKWTVNGDT------RVGLFAVCDIPAGTELTFNYNL--DCLGNEKTV---------------------CRCGA 134


                ....*..
gi 6755702  405 TACRKYL 411
Cdd:cd19211 135 PNCSGFL 141
SET_SETD8 cd10528
SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins; SETD8 (EC 2. ...
 252-365 7.93e-20

SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins; SETD8 (EC 2.1.1.43; also termed N-lysine methyltransferase KMT5A, H4-K20-HMTase KMT5A, lysine N-methyltransferase 5A, lysine-specific methylase 5A, PR/SET domain-containing protein 07, PR-Set7 or PR/SET07) is a nucleosomal histone-lysine N-methyltransferase that specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). It plays a central role in the silencing of euchromatic genes.


Pssm-ID: 380926 [Multi-domain]  Cd Length: 141  Bit Score: 84.94  E-value: 7.93e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  252 DGRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIY--DRQGATYLFDLDYVEDVYTVDAA----YYGNIshfVNHS 325
Cdd:cd10528  25 DGKGRGVIATRPFEKGDFVVEYHGDLITITEAKKREALYakDPSTGCYMYYFQYKGKTYCVDATkesgRLGRL---INHS 101

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 6755702  326 C-DPNLQVYNVFIDNlderLPRIAFFATRTIWAGEELTFDY 365
Cdd:cd10528 102 KkKPNLKTKLLVIDG----VPHLILVAKRDIKPGEELLYDY 138
SET_NSD1 cd19210
SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing ...
 247-411 5.39e-19

SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins; NSD1 (EC 2.1.1.43; also termed Histone-lysine N-methyltransferase H3 lysine-36 and H4 lysine-20 specific, androgen receptor coactivator 267 kDa protein (ARA267), androgen receptor-associated protein of 267 kDa, H3-K36-HMTase, H4-K20-HMTase, lysine N-methyltransferase 3B (KMT3B), or NR-binding SET domain-containing protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4. NSD1 is altered in approximately 10% of head and neck cancer patients with 55% decrease in risk of death in NSD1-mutated versus non-mutated patients; its disruption promotes favorable chemotherapeutic responses linked to hypomethylation.


Pssm-ID: 380987 [Multi-domain]  Cd Length: 142  Bit Score: 83.05  E-value: 5.39e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  247 IFRTNdGRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGATYLFDLDYVEDvYTVDAAYYGNISHFVNHSC 326
Cdd:cd19210   6 IFRTL-GRGWGLRCKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTLDKD-RIIDAGPKGNYARFMNHCC 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  327 DPN--LQVYNVFIDNlderlpRIAFFATRTIWAGEELTFDYNMQVdpvdmestrmdsnfglaglPGSPKKrvriECKCGT 404
Cdd:cd19210  84 QPNceTQKWTVNGDT------RVGLFALCDIKAGTELTFNYNLEC-------------------LGNGKT----VCKCGA 134


                ....*..
gi 6755702  405 TACRKYL 411
Cdd:cd19210 135 PNCSGFL 141
SET_KMT2A cd19206
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A) ...
 235-411 5.66e-19

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A) and similar proteins; KMT2A (EC2.1.1.43; also termed lysine N-methyltransferase 2A, ALL-1, CXXC-type zinc finger protein 7 (CXXC7), myeloid/lymphoid or mixed-lineage leukemia (MLL), myeloid/lymphoid or mixed-lineage leukemia protein 1 (MLL1), trithorax-like protein (TRX1), or zinc finger protein HRX) acts as a histone methyltransferase that plays an essential role in early development and hematopoiesis. It is a catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac).


Pssm-ID: 380983 [Multi-domain]  Cd Length: 154  Bit Score: 83.15  E-value: 5.66e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  235 RVVQKGIRYDLCIFRTN-DGRGWGVRtlEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQG-ATYLFDLDyveDVYTVDA 312
Cdd:cd19206   6 RHLKKTSKEAVGVYRSPiHGRGLFCK--RNIDAGEMVIEYSGNVIRSILTDKREKYYDSKGiGCYMFRID---DSEVVDA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  313 AYYGNISHFVNHSCDPNLQVYNVFIDNLDErlprIAFFATRTIWAGEELTFDYNMqvdPVDMESTRMdsnfglaglpgsp 392
Cdd:cd19206  81 TMHGNAARFINHSCEPNCYSRVINIDGQKH----IVIFAMRKIYRGEELTYDYKF---PIEDASNKL------------- 140

                       170
                ....*....|....*....
gi 6755702  393 kkrvriECKCGTTACRKYL 411
Cdd:cd19206 141 ------PCNCGAKKCRKFL 153
SET_SETD5-like cd10529
SET domain found in SET domain-containing protein 5 (SETD5), inactive histone-lysine ...
 257-367 1.43e-15

SET domain found in SET domain-containing protein 5 (SETD5), inactive histone-lysine N-methyltransferase 2E (KMT2E) and similar proteins; SETD5 is a probable transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. KMT2E (also termed inactive lysine N-methyltransferase 2E or myeloid/lymphoid or mixed-lineage leukemia protein 5 (MLL5)) associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription. The family also includes Saccharomyces cerevisiae SET domain-containing proteins, SET3 and SET4, and Schizosaccharomyces pombe SET3. Most of these family members contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380927  Cd Length: 127  Bit Score: 72.69  E-value: 1.43e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  257 GVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDR-QGATYLFDLDYVEDVYtVDAAYYGNISHFVNHSCDPNLQVYNV 335
Cdd:cd10529  18 GLVATEDISPGEPILEYKGEVSLRSEFKEDNGFFKRpSPFVFFYDGFEGLPLC-VDARKYGNEARFIRRSCRPNAELRHV 96

                        90       100       110
                ....*....|....*....|....*....|....
gi 6755702  336 FIDNldERLpRIAFFATRTIWAGEELT--FDYNM 367
Cdd:cd10529  97 VVSN--GEL-RLFIFALKDIRKGTEITipFDYDY 127
SET_KMT2D cd19209
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) ...
 254-411 3.47e-15

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins; KMT2D (EC2.1.1.43; also termed lysine N-methyltransferase 2D, ALL1-related protein (ALR), or myeloid/lymphoid or mixed-lineage leukemia protein 2 (MLL2)), acts as histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me). It is a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription. KMT2D is a subunit of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation.


Pssm-ID: 380986 [Multi-domain]  Cd Length: 155  Bit Score: 72.42  E-value: 3.47e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  254 RGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQG-ATYLFDLDyveDVYTVDAAYYGNISHFVNHSCDPNLQV 332
Cdd:cd19209  26 QGLGLYAAKDLEKHTMVIEYIGTIIRNEVANRREKIYEEQNrGIYMFRIN---NEHVIDATLTGGPARYINHSCAPNCVA 102

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6755702  333 YNVFIDNLDerlpRIAFFATRTIWAGEELTFDYNMqvdpvDMESTRMDsnfglaglpgspkkrvrIECKCGTTACRKYL 411
Cdd:cd19209 103 EVVTFDKED----KIIIISSRRIPKGEELTYDYQF-----DFEDDQHK-----------------IPCHCGAWNCRKWM 155
CD_CSD cd00024
CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains; Members of this ...
 43-91 4.34e-15

CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains; Members of this group are chromodomains or chromo shadow domains; these are SH3-fold-beta-barrel domains of the chromo-like superfamily. Chromodomains lack the first strand of the SH3-fold-beta-barrel, this first strand is altered by insertion in the chromo shadow domains. The chromodomain is a conserved region of about 50 amino acids, found in a variety of chromosomal proteins, and which appears to play a role in the functional organization of the eukaryotic nucleus. The chromodomain is implicated in the binding, of the proteins in which it is found, to methylated histone tails and maybe RNA. Chromodomain-containing proteins include: i) those having an N-terminal chromodomain followed by a related chromo shadow domain, such as Drosophila and human heterochromatin protein Su(var)205 (HP1), and mammalian modifier 1 and 2; ii) those having a single chromodomain, such as Drosophila protein Polycomb (Pc), mammalian modifier 3, human Mi-2 autoantigen, and several yeast and Caenorhabditis elegans proteins of unknown function; iii) those having paired tandem chromodomains, such as mammalian DNA-binding/helicase proteins CHD-1 to CHD-4 and yeast protein CHD1; (iv) and elongation factor eEF3, a member of the ATP-binding cassette (ABC) family of proteins, that serves an essential function in the translation cycle of fungi. eEF3 is a soluble factor lacking a transmembrane domain and having two ABC domains arranged in tandem, with a unique chromodomain inserted within the ABC2 domain.


Pssm-ID: 349274 [Multi-domain]  Cd Length: 50  Bit Score: 69.04  E-value: 4.34e-15
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 6755702   43 FEVEYLCDYKKIREQEYYLVKWRGYPDSENTWEPRQNLK-CIRVLKQFHK 91
Cdd:cd00024   1 YEVEKILDHRVRKGKLEYLVKWKGYPPEENTWEPEENLTnAPELIKEYEK 50
SET_KMT2C cd19208
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C) ...
 254-411 6.64e-15

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C) and similar proteins; KMT2C (EC2.1.1.43; also termed lysine N-methyltransferase 2C, homologous to ALR protein (HALR) myeloid/lymphoid, or mixed-lineage leukemia protein 3 (MLL3)), acts as a histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me) and may be involved in leukemogenesis and developmental disorder. KMT2C is a catalytic subunit of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. Overexpression of KMT2C is associated with estrogen receptor-positive breast cancer; KMT2C mediates the estrogen dependence of breast cancer through regulation of estrogen receptor alpha (ERalpha) enhancer function. KMT2C is frequently mutated in certain populations with diffuse-type gastric adenocarcinomas (DGA); its loss promotes epithelial-to-mesenchymal transition (EMT) and is associated with worse overall survival.


Pssm-ID: 380985 [Multi-domain]  Cd Length: 154  Bit Score: 71.58  E-value: 6.64e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  254 RGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQG-ATYLFDLDyveDVYTVDAAYYGNISHFVNHSCDPNLQV 332
Cdd:cd19208  25 QGLGLYAARDIEKHTMVIEYIGTIIRNEVANRKEKLYESQNrGVYMFRID---NDHVIDATLTGGPARYINHSCAPNCVA 101

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6755702  333 YNVFIdnldERLPRIAFFATRTIWAGEELTFDYNMqvdpvDMESTRMdsnfglaglpgspkkrvRIECKCGTTACRKYL 411
Cdd:cd19208 102 EVVTF----EKGHKIIISSSRRIQKGEELCYDYKF-----DFEDDQH-----------------KIPCHCGAVNCRKWM 154
SET_SETD1A cd19204
SET domain (including post-SET domain) found in SET domain-containing protein 1A (SETD1A) and ...
 256-411 1.03e-14

SET domain (including post-SET domain) found in SET domain-containing protein 1A (SETD1A) and similar proteins; SETD1A (EC2.1.1.43), also termed lysine N-methyltransferase 2F, or Set1/Ash2 histone methyltransferase complex subunit SET1, is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me), when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. Human SET domain containing protein 1A (hSETD1A) expression occurs at a high rate in hepatocellular carcinoma patients and controls tumor metastasis in breast cancer by activating MMP expression.


Pssm-ID: 380981 [Multi-domain]  Cd Length: 153  Bit Score: 71.21  E-value: 1.03e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  256 WGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQ--GATYLFDLDYVEdvyTVDAAYYGNISHFVNHSCDPNLQVY 333
Cdd:cd19204  26 WGLFAMEPIAADEMVIEYVGQNIRQVVADMREKRYVQEgiGSSYLFRVDHDT---IIDATKCGNLARFINHCCTPNCYAK 102

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6755702  334 NVFIdnldERLPRIAFFATRTIWAGEELTFDYNMqvdpvdmestrmdsnfglaglpgsPKKRVRIECKCGTTACRKYL 411
Cdd:cd19204 103 VITI----ESQKKIVIYSKQPIGVNEEITYDYKF------------------------PIEDNKIPCLCGTENCRGTL 152
SET_KMT2B cd19207
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2B (KMT2B) ...
 255-411 6.94e-14

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2B (KMT2B) and similar proteins; KMT2B (EC2.1.1.43; also termed lysine N-methyltransferase 2B, myeloid/lymphoid or mixed-lineage leukemia protein 4 (MLL2/MLL4), trithorax homolog 2 (TRX2), or WW domain-binding protein 7 (WBP-7)), acts as a histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me). It is required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that precedes resumption of meiosis, oocyte survival and normal zygotic genome activation.


Pssm-ID: 380984 [Multi-domain]  Cd Length: 154  Bit Score: 68.90  E-value: 6.94e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  255 GWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQG-ATYLFDLDyveDVYTVDAAYYGNISHFVNHSCDPNLQVY 333
Cdd:cd19207  25 GRGLFCKRNIDAGEMVIEYSGIVIRSVLTDKREKFYDSKGiGCYMFRID---DFDVVDATMHGNAARFINHSCEPNCYSR 101

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6755702  334 NVFIdnldERLPRIAFFATRTIWAGEELTFDYNMqvdPVDMESTRMdsnfglaglpgspkkrvriECKCGTTACRKYL 411
Cdd:cd19207 102 VIHV----EGQKHIVIFALRKIYRGEELTYDYKF---PIEDASNKL-------------------PCNCGAKRCRRFL 153
Chromo pfam00385
Chromo (CHRromatin organization MOdifier) domain;
43-91 8.86e-14

Chromo (CHRromatin organization MOdifier) domain;


Pssm-ID: 459793 [Multi-domain]  Cd Length: 52  Bit Score: 65.29  E-value: 8.86e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 6755702     43 FEVEYLCDYKKIREQ-EYYLVKWRGYPDSENTWEPRQNL-KCIRVLKQFHK 91
Cdd:pfam00385   1 YEVERILDHRKDKGGkEEYLVKWKGYPYDENTWEPEENLsKCPELIEEFKD 51
SET cd08161
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, ...
 318-366 1.05e-12

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, Enhancer-of-zeste, Trithorax (SET) domain superfamily corresponds to SET domain-containing lysine methyltransferases, which catalyze site and state-specific methylation of lysine residues in histones that are fundamental in epigenetic regulation of gene activation and silencing in eukaryotic organisms. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains has been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as N-SET and C-SET. C-SET forms an unusual and conserved knot-like structure of probable functional importance. In addition to N-SET and C-SET, an insert region (I-SET) and flanking regions of high structural variability form part of the overall structure. Some family members contain a pre-SET domain, which is found in a number of histone methyltransferases (HMTase), and a post-SET domain, which harbors a zinc-binding site.


Pssm-ID: 380914 [Multi-domain]  Cd Length: 72  Bit Score: 63.04  E-value: 1.05e-12
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 6755702  318 ISHFVNHSCDPNLQVYNVFIDnldeRLPRIAFFATRTIWAGEELTFDYN 366
Cdd:cd08161  28 LARFINHSCEPNCEFEEVYVG----GKPRVFIVALRDIKAGEELTVDYG 72
SET_SETD1B cd19205
SET domain (including post-SET domain) found in SET domain-containing protein 1B (SETD1B) and ...
 256-411 3.20e-12

SET domain (including post-SET domain) found in SET domain-containing protein 1B (SETD1B) and similar proteins; SETD1B (EC2.1.1.43), also termed lysine N-methyltransferase 2G, is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me) when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. Loss of SETD1B occurs in up to half the gastric and colorectal cancers, most commonly via SETD1B mutations, while de novo variants in SETD1B are associated with intellectual disability, epilepsy and autism.


Pssm-ID: 380982 [Multi-domain]  Cd Length: 153  Bit Score: 63.92  E-value: 3.20e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  256 WGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQG--ATYLFDLDYVEdvyTVDAAYYGNISHFVNHSCDPNLQVY 333
Cdd:cd19205  26 WGLFAMEPIAADEMVIEYVGQNIRQVIADMREKRYEDEGigSSYMFRVDHDT---IIDATKCGNFARFINHSCNPNCYAK 102

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6755702  334 NVFIdnldERLPRIAFFATRTIWAGEELTFDYNMqvdPVDMEstrmdsnfglaglpgspkkrvRIECKCGTTACRKYL 411
Cdd:cd19205 103 VITV----ESQKKIVIYSKQHINVNEEITYDYKF---PIEDV---------------------KIPCLCGSENCRGTL 152
chromodomain cd18968
CHROMO (CHRromatin Organization Modifier) domain; uncharacterized subgroup; The chromodomain ...
 42-89 1.22e-11

CHROMO (CHRromatin Organization Modifier) domain; uncharacterized subgroup; The chromodomain is a conserved region of about 50 amino acids, found in a variety of chromosomal proteins. The chromodomain is implicated in the binding, of the proteins in which it is found, to methylated histone tails and maybe RNA. A chromodomain may occur as a single instance, in a tandem arrangement, or followed by a related chromo shadow domain. Chromodomains belong to the chromo-like superfamily of SH3-fold-beta-barrel domains which includes chromo shadow domains and chromo barrel domains. Chromodomains differ from these in that they lack the first strand of the SH3-fold-beta-barrel. This first strand is altered by insertion in the chromo shadow domains, and chromo barrel domains are typical SH3-fold-beta-barrel domains with sequence similarity to the canonical chromo domain.


Pssm-ID: 349324  Cd Length: 57  Bit Score: 59.28  E-value: 1.22e-11
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 6755702   42 DFEVEYLC-----DYKKIREQEY-YLVKWRGYPDSENTWEPRQNLK-CIRVLKQF 89
Cdd:cd18968   1 EYEVEVILaarvvKDAESRKKGWkYLVKWAGYPDEENTWEPEESFDgCDDLLERF 55
CD_MarY1_POL_like cd18975
chromodomain of Tricholoma matsutake polyprotein, and similar proteins; This subgroup includes ...
 43-91 3.85e-11

chromodomain of Tricholoma matsutake polyprotein, and similar proteins; This subgroup includes the CHROMO (CHRromatin Organization Modifier) domain found in the polyprotein from the MarY1 Ty3/Gypsy long terminal repeat (LTR) retroelement from the from the Ectomycorrhizal Basidiomycete Tricholoma matsutake. The pol gene in TY3/gypsy elements generally encodes domains in the following order: prt-reverse transcriptase-RNase H-integrase, in marY1 POL the chromodomain is found at the C-terminus of the integrase domain. The chromodomain, is a conserved region of about 50 amino acids, found in a variety of chromosomal proteins, and implicated in the binding, of the proteins in which it is found, to methylated histone tails and maybe RNA. A chromodomain may occur as a single instance, in a tandem arrangement, or followed by a related chromo shadow domain.


Pssm-ID: 349331  Cd Length: 49  Bit Score: 57.94  E-value: 3.85e-11
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 6755702   43 FEVEYLCDYKKIREQEYYLVKWRGYPDSENTWEPRQNLKCIRVLKQFHK 91
Cdd:cd18975   1 YEVESILNSRLHRGKLQYLIQWKGYPLEEASWELEDNIKNPRLIEEFHK 49
CHROMO smart00298
Chromatin organization modifier domain;
42-92 6.16e-11

Chromatin organization modifier domain;


Pssm-ID: 214605 [Multi-domain]  Cd Length: 55  Bit Score: 57.22  E-value: 6.16e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 6755702      42 DFEVEYLCDYKKIREQEY-YLVKWRGYPDSENTWEPRQNLK-CIRVLKQFHKD 92
Cdd:smart00298   1 EYEVEKILDHRWKKKGELeYLVKWKGYSYSEDTWEPEENLLnCSKKLDNYKKK 53
CD_HP1a_insect cd18653
chromodomain of insect HP1a; CHRomatin Organization Modifier (chromo) domain of insect HP1a. ...
 42-89 1.04e-10

chromodomain of insect HP1a; CHRomatin Organization Modifier (chromo) domain of insect HP1a. HP1a is a member of the heterochromatin protein family, and is enriched in the heterochromatin and associated with centromeres. HP1 has diverse functions in heterochromatin formation and impacts both gene expression and gene silencing. HP1 has two conserved protein-protein interaction domains, a single N-terminal chromodomain (CD) which can bind to histone proteins via methylated lysine residues, and a related C-terminal chromo shadow domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated non-histone proteins; a flexible hinge region separates the CD and CSD and may bind nucleic acid. HP1 is a highly conserved non-histone chromosomal protein that is evolutionarily conserved from fission yeast to plants and animals. In Drosophila, there are at least five HP1 family proteins, this subgroup includes the CD of Drosophila melanogaster HP1a.


Pssm-ID: 349300  Cd Length: 50  Bit Score: 56.58  E-value: 1.04e-10
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 6755702   42 DFEVEYLCDyKKIREQ--EYYLvKWRGYPDSENTWEPRQNLKCIRVLKQF 89
Cdd:cd18653   1 EYAVEKICD-RRVRKGkvEYYL-KWKGYPETENTWEPEENLDCQDLIQQY 48
CD_POL_like cd18974
chromodomain of Penicillium solitum protein PENSOL_c198G03123; This subgroup includes the ...
 43-91 1.70e-10

chromodomain of Penicillium solitum protein PENSOL_c198G03123; This subgroup includes the CHROMO (CHRromatin Organization Modifier) domain found in Penicillium solitum protein PENSOL_c198G03123 a putative polyprotein from a Ty3/Gypsy long terminal repeat (LTR) retroelement. The pol gene in TY3/gypsy elements generally encodes domains in the following order: an aspartyl protease, a reverse transcriptase, RNase H, and an integrase, here the chromodomain is found at the C-terminus of the integrase domain. The chromodomain, is a conserved region of about 50 amino acids, found in a variety of chromosomal proteins, and implicated in the binding, of the proteins in which it is found, to methylated histone tails and maybe RNA. A chromodomain may occur as a single instance, in a tandem arrangement, or followed by a related chromo shadow domain.


Pssm-ID: 349330  Cd Length: 50  Bit Score: 55.95  E-value: 1.70e-10
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 6755702   43 FEVEYLCDYKKIREQEYYLVKWRGYPDSENTWEPRQNLK-CIRVLKQFHK 91
Cdd:cd18974   1 WEVEEIVDEKMIDDELHYLVKWKGWPAEYNQWEPEDDMEnAPKAIQSYEK 50
CD_HP1_like cd18960
chromodomain of heterochromatin protein 1 proteins, including HP1alpha, HP1beta, and HP1gamma; ...
 43-91 3.76e-10

chromodomain of heterochromatin protein 1 proteins, including HP1alpha, HP1beta, and HP1gamma; uncharacterized subgroup; CHRomatin Organization Modifier (chromo) domain of mammalian HP1alpha (Cbx5), HP1beta (Cbx1), HP1gamma (Cbx5), and similar proteins. HP1 has diverse functions in heterochromatin formation and impacts both gene expression and gene silencing. HP1 has two conserved protein-protein interaction domains, a single N-terminal chromodomain (CD) which can bind to histone proteins via methylated lysine residues, and a related C-terminal chromo shadow domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated non-histone proteins; a flexible hinge region separates the CD and CSD and may bind nucleic acid. HP1 is a highly conserved non-histone chromosomal protein that is evolutionarily conserved from fission yeast to plants and animals. There are three human homologs of HP1 proteins: HP1alpha (also known as Cbx5), HP1beta (also known as Cbx1), and HP1gamma (also known as Cbx3).


Pssm-ID: 349316  Cd Length: 51  Bit Score: 55.26  E-value: 3.76e-10
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 6755702   43 FEVEYLCDYKKIRE-QEYYLVKWRGYPDSENTWEPRQNLKCIRVLKQFHK 91
Cdd:cd18960   2 FVVERILDKRLGRNgGEEFLIKWQGFPESDSSWEPRENLQCDEMLEEFEK 51
CD_Tf2-1_POL_like cd18973
chromodomain of Rhizoctonia solani AG-1 IB retrotransposable element Tf2 155 kDa protein type ...
 43-91 4.37e-10

chromodomain of Rhizoctonia solani AG-1 IB retrotransposable element Tf2 155 kDa protein type 1, and similar proteins; This subgroup includes the CHROMO (CHRromatin Organization Modifier) domain found in Rhizoctonia solani AG-1 IB retrotransposable element Tf2 155 kDa protein type 1 (Tf2-1), and similar proteins. It belongs to the Ty3/gypsy family of long terminal repeat (LTR) retrotransposons. The pol gene in TY3/gypsy elements generally encodes domains in the following order: an aspartyl protease, a reverse transcriptase, RNase H, and an integrase, here the chromodomain is found at the C-terminus of the integrase domain. The chromodomain, is a conserved region of about 50 amino acids, found in a variety of chromosomal proteins, and implicated in the binding, of the proteins in which it is found, to methylated histone tails and maybe RNA. A chromodomain may occur as a single instance, in a tandem arrangement, or followed by a related chromo shadow domain.


Pssm-ID: 349329  Cd Length: 50  Bit Score: 54.95  E-value: 4.37e-10
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 6755702   43 FEVEYLCDYKKIREQEYYLVKWRGYPDSENTWEPRQNLK-CIRVLKQFHK 91
Cdd:cd18973   1 YVVEAILDNKRRKGKWLYLVKWKGYGPEHNTWEPRENLEhAQKLLKKYYQ 50
CD_HP1_like cd18631
chromodomain of heterochromatin protein 1 proteins, including HP1alpha, HP1beta, and HP1gamma; ...
 42-91 6.45e-10

chromodomain of heterochromatin protein 1 proteins, including HP1alpha, HP1beta, and HP1gamma; CHRomatin Organization Modifier (chromo) domain of mammalian HP1alpha (Cbx5), HP1beta (Cbx1), HP1gamma (Cbx5), and similar proteins. HP1 has diverse functions in heterochromatin formation and impacts both gene expression and gene silencing. HP1 has two conserved protein-protein interaction domains, a single N-terminal chromodomain (CD) which can bind to histone proteins via methylated lysine residues, and a related C-terminal chromo shadow domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated non-histone proteins; a flexible hinge region separates the CD and CSD and may bind nucleic acid. HP1 is a highly conserved non-histone chromosomal protein that is evolutionarily conserved from fission yeast to plants and animals. There are three human homologs of HP1 proteins: HP1alpha (also known as Cbx5), HP1beta (also known as Cbx1), and HP1gamma (also known as Cbx3).


Pssm-ID: 349281  Cd Length: 50  Bit Score: 54.37  E-value: 6.45e-10
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 6755702   42 DFEVEYLCDYKKIREQEYYLVKWRGYPDSENTWEPRQNLKCIRVLKQFHK 91
Cdd:cd18631   1 EYVVEKVLDRRVVKGKVEYLLKWKGYPDEDNTWEPEENLDCPDLIAEFEE 50
CD_POL_like cd18976
chromodomain of uncharacterized putative retroelement polyprotein proteins; This subgroup ...
 45-89 1.95e-09

chromodomain of uncharacterized putative retroelement polyprotein proteins; This subgroup includes the CHROMO (CHRromatin Organization Modifier) domain found in uncharacterized putative retrotransposon proteins, and similar proteins. The chromodomain, is a conserved region of about 50 amino acids, found in a variety of chromosomal proteins, and implicated in the binding, of the proteins in which it is found, to methylated histone tails and maybe RNA. A chromodomain may occur as a single instance, in a tandem arrangement, or followed by a related chromo shadow domain.


Pssm-ID: 349332  Cd Length: 51  Bit Score: 52.95  E-value: 1.95e-09
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 6755702   45 VEYLCDYKKIREQEYYLVKWRGYPDSENTWEPRQNL--KCIRVLKQF 89
Cdd:cd18976   3 VESLLDRRKVRGQVQYLVKWRGFPRSEATWEPREELmrRCAELVAAY 49
chromodomain cd18966
CHROMO (CHRromatin Organization Modifier) domain; uncharacterized subgroup; The chromodomain ...
 43-80 2.68e-09

CHROMO (CHRromatin Organization Modifier) domain; uncharacterized subgroup; The chromodomain is a conserved region of about 50 amino acids, found in a variety of chromosomal proteins. The chromodomain is implicated in the binding, of the proteins in which it is found, to methylated histone tails and maybe RNA. A chromodomain may occur as a single instance, in a tandem arrangement, or followed by a related chromo shadow domain. Chromodomains belong to the chromo-like superfamily of SH3-fold-beta-barrel domains which includes chromo shadow domains and chromo barrel domains. Chromodomains differ from these in that they lack the first strand of the SH3-fold-beta-barrel. This first strand is altered by insertion in the chromo shadow domains, and chromo barrel domains are typical SH3-fold-beta-barrel domains with sequence similarity to the canonical chromo domain.


Pssm-ID: 349322  Cd Length: 49  Bit Score: 52.67  E-value: 2.68e-09
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 6755702   43 FEVEYLCDYKKIREQEYYLVKWRGYPDSENTWEPRQNL 80
Cdd:cd18966   1 YEVERILAERRDDGGKRYLVKWEGYPLEEATWEPEENI 38
SET_SpSet7-like cd10540
SET domain found in Schizossacharomyces pombe Set7 and similar proteins; Schizosaccharomyces ...
 247-366 4.02e-09

SET domain found in Schizossacharomyces pombe Set7 and similar proteins; Schizosaccharomyces pombe Set7 is a novel histone-lysine N-methyltransferase. The family also includes a viral histone H3 lysine 27 methyltransferase from Paramecium bursaria Chlorella virus 1 (PBCV-1).


Pssm-ID: 380938  Cd Length: 112  Bit Score: 53.80  E-value: 4.02e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  247 IFRTNDGRGWGVRTLEKIRKNSFVmEYVGEIITSEEaERRGQIYdrqgaTYLFDLDYV-EDVYTVDAAYYGniSHFvNHS 325
Cdd:cd10540   3 EVKPSTLKGRGVFATRPIKKGEVI-EEAPVIVLPKE-EYQHLCK-----TVLDHYVFSwGDGCLALALGYG--SMF-NHS 72

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 6755702  326 CDPNLQVYnvfidnLDERLPRIAFFATRTIWAGEELTFDYN 366
Cdd:cd10540  73 YTPNAEYE------IDFENQTIVFYALRDIEAGEELTINYG 107
CD_HP1alpha_Cbx5 cd18651
chromodomain of heterochromatin protein 1 homolog alpha; CHRomatin Organization Modifier ...
 42-91 4.33e-09

chromodomain of heterochromatin protein 1 homolog alpha; CHRomatin Organization Modifier (chromo) domain of heterochromatin protein 1 homolog alpha (also known as HP1alpha, Cbx5, and Chromobox 5), and related proteins. HP1alpha has diverse functions in heterochromatin formation, gene regulation, and mitotic progression, and forms complex networks of gene, RNA, and protein interactions. HP1 has two conserved protein-protein interaction domains, a single N-terminal chromodomain (CD) which can bind to histone proteins via methylated lysine residues, and a related C-terminal chromo shadow domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated non-histone proteins; a flexible hinge region separates the CD and CSD and may bind nucleic acid. HP1 is a highly conserved non-histone chromosomal protein that is evolutionarily conserved from fission yeast to plants and animals. There are three human homologs of HP1 proteins: HP1alpha, HP1beta (also known as Cbx1), and HP1gamma (also known as Cbx3).


Pssm-ID: 349298  Cd Length: 50  Bit Score: 51.92  E-value: 4.33e-09
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 6755702   42 DFEVEYLCDYKKIREQEYYLVKWRGYPDSENTWEPRQNLKCIRVLKQFHK 91
Cdd:cd18651   1 EYVVEKVLDRRVVKGQVEYLLKWKGFSEEHNTWEPEKNLDCPELISEFMK 50
chromodomain cd18965
CHROMO (CHRromatin Organization Modifier) domain; uncharacterized subgroup; The chromodomain ...
 45-95 7.28e-09

CHROMO (CHRromatin Organization Modifier) domain; uncharacterized subgroup; The chromodomain is a conserved region of about 50 amino acids, found in a variety of chromosomal proteins. The chromodomain is implicated in the binding, of the proteins in which it is found, to methylated histone tails and maybe RNA. A chromodomain may occur as a single instance, in a tandem arrangement, or followed by a related chromo shadow domain. Chromodomains belong to the chromo-like superfamily of SH3-fold-beta-barrel domains which includes chromo shadow domains and chromo barrel domains. Chromodomains differ from these in that they lack the first strand of the SH3-fold-beta-barrel. This first strand is altered by insertion in the chromo shadow domains, and chromo barrel domains are typical SH3-fold-beta-barrel domains with sequence similarity to the canonical chromo domain.


Pssm-ID: 349321  Cd Length: 53  Bit Score: 51.32  E-value: 7.28e-09
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 6755702   45 VEYLCDYKKIREQEYYLVKWRGYPDSENTWEPRQNLKCIRVLKQFHKDLER 95
Cdd:cd18965   3 IEALLKKRQFNRKLEYLVKWHGLPESENTWEREKDIKHVSHWKQLLKDLRA 53
CD_HP1gamma_Cbx3 cd18652
chromodomain of heterochromatin protein 1 homolog gamma; CHRomatin Organization Modifier ...
 42-89 1.10e-08

chromodomain of heterochromatin protein 1 homolog gamma; CHRomatin Organization Modifier (chromo) domain of heterochromatin protein 1 homolog gamma (also known as HP1gamma, Cbx3, and Chromobox 3), and related proteins. HP1gamma is a highly conserved non-histone protein, which is a member of the heterochromatin protein family, and is enriched in the heterochromatin and associated with centromeres. HP1 has two conserved protein-protein interaction domains, a single N-terminal chromodomain (CD) which can bind to histone proteins via methylated lysine residues, and a related C-terminal chromo shadow domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated non-histone proteins; a flexible hinge region separates the CD and CSD and may bind nucleic acid. In addition to being involved in transcriptional silencing in heterochromatin-like complexes, HP1gamma also binds lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the protein may explain the association of heterochromatin with the inner nuclear membrane. HP1gamma is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. HP1 is a highly conserved non-histone chromosomal protein that is evolutionarily conserved from fission yeast to plants and animals. There are three human homologs of HP1 proteins: HP1alpha (also known as Cbx5), HP1beta (also known as Cbx1), and HP1gamma.


Pssm-ID: 349299  Cd Length: 50  Bit Score: 50.78  E-value: 1.10e-08
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 6755702   42 DFEVEYLCDYKKIREQEYYLVKWRGYPDSENTWEPRQNLKCIRVLKQF 89
Cdd:cd18652   1 EFVVEKVLDRRVVNGKVEYFLKWKGFTDADNTWEPEENLDCPELIEAF 48
CD_HP1beta_Cbx1 cd18650
chromodomain of heterochromatin protein 1 homolog beta; CHRomatin Organization Modifier ...
 42-89 1.60e-08

chromodomain of heterochromatin protein 1 homolog beta; CHRomatin Organization Modifier (chromo) domain of heterochromatin protein 1 homolog beta (also known as HP1beta, CBX1, and chromobox 1), and related proteins. HP1beta is a highly conserved non-histone protein, which is a member of the heterochromatin protein family, and is enriched in the heterochromatin and associated with centromeres. HP1 has two conserved protein-protein interaction domains, a single N-terminal chromodomain (CD) which can bind to histone proteins via methylated lysine residues, and a related C-terminal chromo shadow domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated non-histone proteins; a flexible hinge region separates the CD and CSD and may bind nucleic acid. HP1 is a highly conserved non-histone chromosomal protein that is evolutionarily conserved from fission yeast to plants and animals. There are three human homologs of HP1 proteins: HP1alpha (also known as Cbx5), HP1beta, and HP1gamma (also known as Cbx3).


Pssm-ID: 349297  Cd Length: 50  Bit Score: 50.33  E-value: 1.60e-08
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 6755702   42 DFEVEYLCDYKKIREQEYYLVKWRGYPDSENTWEPRQNLKCIRVLKQF 89
Cdd:cd18650   1 EYVVEKVLDRRVVKGKVEYLLKWKGFSDEDNTWEPEENLDCPDLIAEF 48
CD_NC-like cd18980
chromodomain of a Tasahii var. asahii CBS 8904 retrotransposon nucleocapsid protein, and ...
 42-90 2.78e-08

chromodomain of a Tasahii var. asahii CBS 8904 retrotransposon nucleocapsid protein, and similar proteins; This subgroup includes the CHROMO (CHRromatin Organization Modifier) domain found in Trichosporon asahii var. asahii CBS 8904 retrotransposon nucleocapsid protein, and similar proteins. The chromodomain is implicated in the binding, of the proteins in which it is found, to methylated histone tails and maybe RNA. A chromodomain may occur as a single instance, in a tandem arrangement, or followed by a related chromo shadow domain.


Pssm-ID: 349336  Cd Length: 56  Bit Score: 49.88  E-value: 2.78e-08
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 6755702   42 DFEVEYLCDYK---KIREQEYYLVKWRGYPDSENTWEPRQNLK-CIRVLKQFH 90
Cdd:cd18980   3 EYEVEAILDHKvdrRYRDPNFYLVRWRGYGPSHDSWEPTSALEnAQDLLREFW 55
CD_POL_like cd18972
chromodomain of a Moniliophthora perniciosa FA553 putative retrotransposon polyprotein, and ...
 43-91 3.56e-08

chromodomain of a Moniliophthora perniciosa FA553 putative retrotransposon polyprotein, and similar proteins; This subgroup includes the CHROMO (CHRromatin Organization Modifier) domain found in a Moniliophthora perniciosa FA553 putative retrotelement polyprotein, which includes domains in the following order: a reverse transcriptase, RNase H, and an integrase, here the chromodomain is found at the C-terminus of the integrase domain. The chromodomain, is a conserved region of about 50 amino acids, found in a variety of chromosomal proteins, and implicated in the binding, of the proteins in which it is found, to methylated histone tails and maybe RNA. A chromodomain may occur as a single instance, in a tandem arrangement, or followed by a related "chromo shadow" domain


Pssm-ID: 349328  Cd Length: 50  Bit Score: 49.43  E-value: 3.56e-08
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 6755702   43 FEVEYLCDYKKIREQEYYLVKWRGYPDSENTWEPRQNLK-CIRVLKQFHK 91
Cdd:cd18972   1 YEVEAIVGHKPKKKPRQFLVSWLGYDSSHNEWKQKEELEnARELLQDYLK 50
CD_DDE_transposase_like cd18978
chromodomain of Rhizopus microsporus putative DDE transposases, and similar proteins; This ...
 42-91 6.79e-08

chromodomain of Rhizopus microsporus putative DDE transposases, and similar proteins; This subgroup includes the CHROMO (CHRromatin Organization Modifier) domain found in Rhizopus microsporus putative DDE transposases, and similar proteins. The chromodomain, is a conserved region of about 50 amino acids, found in a variety of chromosomal proteins, and implicated in the binding, of the proteins in which it is found, to methylated histone tails and maybe RNA. A chromodomain may occur as a single instance, in a tandem arrangement, or followed by a related chromo shadow domain.


Pssm-ID: 349334  Cd Length: 52  Bit Score: 48.85  E-value: 6.79e-08
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 6755702   42 DFEVEYLCDYKKIREQEYYLVKWRGYPDSENTWEPRQNLKCIRVLKQFHK 91
Cdd:cd18978   3 SYEVEKIINHRGEKNRRKYLVKWKGYDDTDNSWVTQEDFNDKDMIDEYEN 52
CD_EhHp1_like cd18638
chromodomain of Entamoeba histolytica heterochromatin protein 1, and similar proteins; This ...
 43-91 9.84e-08

chromodomain of Entamoeba histolytica heterochromatin protein 1, and similar proteins; This subgroup includes the N-terminal CHRomatin Organization Modifier (chromo) domain of heterochromatin protein 1 (HP1)-like protein from Entamoeba histolytica, and similar proteins. A chromodomain is a conserved region of about 50 amino acids, found in a variety of chromosomal proteins, and which appears to play a role in the functional organization of the eukaryotic nucleus. The chromodomain is implicated in the binding, of the proteins in which it is found, to methylated histone tails and maybe RNA. A chromodomain may occur as a single instance, in a tandem arrangement, or followed by a related chromo shadow domain.


Pssm-ID: 349288  Cd Length: 52  Bit Score: 48.41  E-value: 9.84e-08
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 6755702   43 FEVEYLCDYKKIREQEYYLVKWRGYPDSENTWEPRQNLK--CIRVLKQFHK 91
Cdd:cd18638   2 FEVEKIVKKKTVKGGTEYFVKWKGYSAKENTWETEDNLEksYKEMIDEFEK 52
SET_SpSET3-like cd19183
SET domain (including post-SET domain) found in Schizosaccharomyces pombe SET ...
 264-365 1.20e-07

SET domain (including post-SET domain) found in Schizosaccharomyces pombe SET domain-containing protein 3 (SETD3) and similar proteins; Schizosaccharomyces pombe SETD3 functions as a transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. It is required for both, gene activation and repression.


Pssm-ID: 380960  Cd Length: 173  Bit Score: 51.25  E-value: 1.20e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  264 IRKNSFVMEYVGEIITSEE--AERRGQiYDRQGATYLFDLDYVEDVYTVDAAYYGNISHFVNHSCDPNLQVYNVFIDNLd 341
Cdd:cd19183  22 IPAGDPIQELLGEIGLQSEyiADPENQ-YQILGAPKPHVFFHPQSPLYIDTRRSGSVARFIRRSCRPNAELVTVASDSG- 99

                        90       100
                ....*....|....*....|....
gi 6755702  342 eRLPRIAFFATRTIWAGEELTFDY 365
Cdd:cd19183 100 -SVLKFVLYASRDISPGEEITIGW 122
SET_SETD5 cd19181
SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and ...
 258-370 1.11e-06

SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins; SETD5 is a probable transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. SETD5 loss-of-function mutations are a likely cause of a familial syndromic intellectual disability with variable phenotypic expression.


Pssm-ID: 380958  Cd Length: 150  Bit Score: 48.08  E-value: 1.11e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  258 VRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGATYLFDLDYVEDVYTVDAAYYGNISHFVNHSCDPNLQVYNVFI 337
Cdd:cd19181  21 LRAARDLALDTLIIEYRGKVMLRQQFEVNGHFFKRPYPFVLFYSKFNGVEMCVDARTFGNDARFIRRSCTPNAEVRHMIA 100

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 6755702  338 DNlderLPRIAFFATRTIWAGEELT--FDY-----NMQVD 370
Cdd:cd19181 101 DG----MIHLCIYAVAAIAKDAEVTiaFDYeysncNYKVD 136
CD_Rhino cd18630
chromodomain of Drosophila melanogaster Rhino, and similar proteins; N-terminal CHRomatin ...
 60-89 1.26e-06

chromodomain of Drosophila melanogaster Rhino, and similar proteins; N-terminal CHRomatin Organization Modifier (chromo) domain of Drosophila melanogaster Rhino (also known as heterochromatin protein 1-like), and similar proteins. Rhino is a female-specific protein that affects chromosome structure and egg polarity that is required for germline PIWI-interacting RNA (piRNA) production. In Drosophila the RDC (rhino, deadlock, and cutoff) complex, composed of rhino, the protein deadlock (Del) and the Rai1-like transcription termination cofactor cutoff (Cuff) binds to chromatin of dual-strand piRNA clusters, special genomic regions, which encode piRNA precursors. The RDC complex is anchored to H3K9me3-marked chromatin in part via the H3K9me3-binding activity of Rhino, and is required for transcription of piRNA precursors. A chromodomain is a conserved region of about 50 amino acids, found in a variety of chromosomal proteins, and which appears to play a role in the functional organization of the eukaryotic nucleus. The chromodomain is implicated in the binding, of the proteins in which it is found, to methylated histone tails and maybe RNA. A chromodomain may occur as a single instance, in a tandem arrangement, or followed by a related chromo shadow domain.


Pssm-ID: 349280  Cd Length: 51  Bit Score: 45.20  E-value: 1.26e-06
                        10        20        30
                ....*....|....*....|....*....|.
gi 6755702   60 YLVKWRGYPDSENTWEPRQNL-KCIRVLKQF 89
Cdd:cd18630  19 VLVKWSGFPNENNTWEPLENLgNCMKLVADY 49
CD_MMP8 cd18633
chromodomain of M-phase phosphoprotein 8; The chromodomain of M-phase phosphoprotein 8 (MPP8), ...
 43-91 1.77e-06

chromodomain of M-phase phosphoprotein 8; The chromodomain of M-phase phosphoprotein 8 (MPP8), a component of the RanBPM-containing large protein complex, binds methylated H3K9. This may in turn recruit the H3K9 methyltransferases GLP and ESET, and DNA methyltransferase 3A to the promoter of the E-cadherin gene, mediating the E-cadherin gene silencing and promoting tumor cell motility and invasion. A chromodomain is a conserved region of about 50 amino acids, found in a variety of chromosomal proteins, and which appears to play a role in the functional organization of the eukaryotic nucleus. The chromodomain is implicated in the binding, of the proteins in which it is found, to methylated histone tails and maybe RNA. A chromodomain may occur as a single instance, in a tandem arrangement, or followed by a related chromo shadow domain.


Pssm-ID: 349283  Cd Length: 51  Bit Score: 44.58  E-value: 1.77e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 6755702   43 FEVEYLCDYKKIREQEYYLVKWRGYPDSENTWEPRQNLK-CIRVLKQFHK 91
Cdd:cd18633   2 FEVEKILDMKTEGGKVLYKVRWKGYTSDDDTWEPEVHLEdCKEVLLEFRK 51
SET_KMT2E cd19182
SET domain found in inactive histone-lysine N-methyltransferase 2E (KMT2E) and similar ...
 267-366 2.39e-06

SET domain found in inactive histone-lysine N-methyltransferase 2E (KMT2E) and similar proteins; KMT2E (also termed inactive lysine N-methyltransferase 2E, myeloid/lymphoid or mixed-lineage leukemia protein 5 (MLL5)) plays a key role in hematopoiesis, spermatogenesis and cell cycle progression. It associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription. Lack of key residues in the SET domain as well as the presence of an unusually large loop in the SET-I subdomain preclude the interaction of MLL5 SET with its cofactor and substrate thus making MLL5 devoid of any in vitro methyltransferase activity on full-length histones and histone H3 peptide.


Pssm-ID: 380959  Cd Length: 129  Bit Score: 46.42  E-value: 2.39e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  267 NSFVMEYVGEIITSEEAERRGQIYDRQGATYLFDLDYVEDVYTVDAAYYGNISHFVNHSCDPNLQVYNVfidnLDERLPR 346
Cdd:cd19182  30 DTLIIEYRGKFMLREQFEANGYFFKRPYPFVLFYSKFHGLEMCVDARTFGNEARFIRRSCTPNAEVRHV----IEDGTIH 105

                        90       100
                ....*....|....*....|..
gi 6755702  347 IAFFATRTIWAGEELT--FDYN 366
Cdd:cd19182 106 LYIYSIRSIPKGTEITiaFDFD 127
CD_Clr4_like cd18632
N-terminal chromodomain of the fission yeast histone methyltransferase Clr4, and similar ...
 42-89 2.66e-06

N-terminal chromodomain of the fission yeast histone methyltransferase Clr4, and similar proteins; N-terminal CHRomatin Organization Modifier (chromo) domain of cryptic loci regulator 4 (Clr4), a histone H3 lysine methyltransferase which targets H3K9. Clr4 regulates silencing and switching at the mating-type loci and affects chromatin structure at centromeres. Clr4 is a catalytic component of the rik1-associated E3 ubiquitin ligase complex that shows ubiquitin ligase activity and is required for histone H3K9 methylation. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting swi6/HP1 to methylated histones which leads to transcriptional silencing within centromeric heterochromatin, telomeric regions and at the silent mating-type loci. A chromodomain is a conserved region of about 50 amino acids, found in a variety of chromosomal proteins, and which appears to play a role in the functional organization of the eukaryotic nucleus. The chromodomain is implicated in the binding, of the proteins in which it is found, to methylated histone tails and maybe RNA. A chromodomain may occur as a single instance, in a tandem arrangement, or followed by a related chromo shadow domain.


Pssm-ID: 349282  Cd Length: 55  Bit Score: 44.42  E-value: 2.66e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 6755702   42 DFEVEYLCDYKKIRE--QEYYLVKWRGYPDSENTWEPRQNLK-CIRVLKQF 89
Cdd:cd18632   1 EYEVEKIVDEKTDRNtaEPLYLVRWKNYSKNHDTWEPAENLSgCQAVLEKW 51
CD_Cbx2 cd18647
chromodomain of chromobox homolog 2; CHRomatin Organization Modifier (chromo) domain of ...
 43-91 2.93e-06

chromodomain of chromobox homolog 2; CHRomatin Organization Modifier (chromo) domain of chromobox homolog 2 (CBX2), a component of the PcG repressive complex PRC1, one of the two classes of PRCs. PcG proteins form large multiprotein complexes (PcG bodies) which are involved in the stable repression of genes involved in development, signaling or cancer via chromatin-based epigenetic modifications. Mammalian PRC1 includes canonical (cPRC1) and non-canonical complexes; cPRC1, contains four core subunits including one CBX protein (CBX2, CBX4, and CBX6-CBX8) that binds H3K27me3. CBX family members have different affinity for H3K27me3, with CBX7 having the highest binding capability. The human CBX proteins show distinct nuclear localizations and contribute differently to transcriptional repression. Some CBX proteins of the PRC1 complex have been implicated in transcriptional activation as well as in PRC1-independent roles in embryonic stem cells and in somatic cells.


Pssm-ID: 349294  Cd Length: 53  Bit Score: 44.28  E-value: 2.93e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 6755702   43 FEVEYLCDYKKIREQEYYLVKWRGYPDSENTWEPRQNLKCIRVLKQFHK 91
Cdd:cd18647   4 FAAECILSKRLRKGKLEYLVKWRGWSSKHNSWEPEENILDPRLLLAFQK 52
SET_SMYD cd20071
SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing ...
 247-371 3.17e-06

SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing protein, and similar proteins; The family includes SET and MYND domain-containing proteins, SMYD1-SYMD5. SMYD1 (EC 2.1.1.43; also termed BOP) is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD2 (also termed HSKM-B, or lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. SMYD5 (also termed protein NN8-4AG, or retinoic acid-induced protein 15) functions as histone lysine methyltransferase that mediates H4K20me3 at heterochromatin regions.


Pssm-ID: 380997 [Multi-domain]  Cd Length: 122  Bit Score: 45.83  E-value: 3.17e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  247 IFRTNDGRGWGVRTLEKIRKnsfvmeyvGEIITSEEAErrgqIYDRQGATYLFDLDYVEDVytvdaAYYGNISHFvNHSC 326
Cdd:cd20071   2 VRESEGSKGRGLVATRDIEP--------GELILVEKPL----VSVPSNSFSLTDGLNEIGV-----GLFPLASLL-NHSC 63

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 6755702  327 DPNLQVynVFIDNlderlPRIAFFATRTIWAGEELTFDYNMQVDP 371
Cdd:cd20071  64 DPNAVV--VFDGN-----GTLRVRALRDIKAGEELTISYIDPLLP 101
CD_polycomb_like cd18627
chromodomain of polycomb and chromobox family proteins; CHRomatin Organization Modifier ...
 52-91 3.48e-06

chromodomain of polycomb and chromobox family proteins; CHRomatin Organization Modifier (chromo) domain of Polycomb and Polycomb-group (PcG) chromobox (CBX) family proteins such as CBX2, CBX4, CBX6, CBX7, and CBX8. These CBX proteins are components of the PcG repressive complex PRC1, one of the two classes of PRCs. PcG proteins form large multiprotein complexes (PcG bodies) which are involved in the stable repression of genes involved in development, signaling or cancer via chromatin-based epigenetic modifications. Mammalian PRC1 includes canonical (cPRC1) and non-canonical complexes; cPRC1, contains four core subunits including one CBX protein (CBX2, CBX4, and CBX6-CBX8) that binds H3K27me3. CBX family members have different affinity for H3K27me3, with CBX7 having the highest binding capability. The human CBX proteins show distinct nuclear localizations and contribute differently to transcriptional repression. Some CBX proteins of the PRC1 complex have been implicated in transcriptional activation as well as in PRC1-independent roles in embryonic stem cells and in somatic cells.


Pssm-ID: 349277  Cd Length: 49  Bit Score: 43.92  E-value: 3.48e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 6755702   52 KKIRE-QEYYLVKWRGYPDSENTWEPRQNLKCIRVLKQFHK 91
Cdd:cd18627   9 KRIRKgKVEYLVKWKGWSQKYNTWEPEENILDPRLLAAFES 49
CD_CDY cd18634
chromodomain of the Chromodomain Y-like protein family; This group includes the chromodomain ...
 43-91 6.11e-06

chromodomain of the Chromodomain Y-like protein family; This group includes the chromodomain found in the mammalian chromodomain Y-like (CDY) protein family, and similar proteins. The human CDY family includes 6 proteins: the genes encoding four of these: two copies of CDY1 (CDY1a, CDY1a) and two copies of CDY2(CDY2a and CDY2b), are located on chromosome Y, and the genes encoding the other two members (CDYL and CDYL2) are located on autosomes. The chromosomal genes are only present in primates, whereas the CDYL and CDYL2 genes exist in most mammalian species. The CDY family proteins contain two functional domains: a chromodomain involved in chromatin binding and a catalytic domain found in many coenzyme A (CoA)- dependent acylation enzymes. CDYL is ubiquitously expressed, whereas CDYL2 shows selective expression in tissues of testis, prostate, spleen, and leukocyte. The CDYL genes are ubiquitously expressed, the CDY genes are only expressed in the testis. Deletion of the CDY1b gene has been shown to be a risk factor for male infertility. Impairments in CDY2 expression could be implicated in the pathogenesis of maturation arrest (a failure of germ cell development).


Pssm-ID: 349284  Cd Length: 52  Bit Score: 43.20  E-value: 6.11e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 6755702   43 FEVEYLCDYKKIREQEY-YLVKWRGYPDSENTWEPRQNLK-CIRVLKQFHK 91
Cdd:cd18634   2 YEVERIVDKRKNKKGKTeYLVRWKGYDSEDDTWEPEQHLLnCEEFIHDFNR 52
CD_CMT3_like cd18635
chromodomain of chromomethylase 3, and similar proteins; CHRomatin Organization Modifier ...
 43-89 6.60e-06

chromodomain of chromomethylase 3, and similar proteins; CHRomatin Organization Modifier (chromo) domain of DNA (cytosine-5)-methyltransferase chromomethylase 3 (CMT3, EC:2.1.1.37), and similar proteins. CMT3 is primarily a CHG (where H is either A, T or C) methyltransferase and is predominantly expressed in actively replicating cells. The protein is involved in preferentially methylating transposon-related sequences, reducing their mobility. Studies suggest that in order to target DNA methylation, CMT3 associates with H3K9me2-containing nucleosomes through binding of its BAH- and chromo-domains to H3K9me2. A chromodomain is a conserved region of about 50 amino acids, found in a variety of chromosomal proteins, and which appears to play a role in the functional organization of the eukaryotic nucleus. The chromodomain is implicated in the binding, of the proteins in which it is found, to methylated histone tails and maybe RNA. A chromodomain may occur as a single instance, in a tandem arrangement, or followed by a related chromo shadow domain.


Pssm-ID: 349285  Cd Length: 57  Bit Score: 43.07  E-value: 6.60e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 6755702   43 FEVEYLCDYKKIREQE------YYLVKWRGYPDSENTWEPRQNL-KCIRVLKQF 89
Cdd:cd18635   2 FEVEKLVGICYGDPKKtgerglYFKVRWKGYGPEEDTWEPIEGLsNCPEKIKEF 55
CD_polycomb cd18644
chromodomain of polycomb; CHRomatin Organization Modifier (chromo) domain of the PcG ...
 43-91 1.13e-05

chromodomain of polycomb; CHRomatin Organization Modifier (chromo) domain of the PcG (polycomb-group) chromodomain protein Polycomb (Pc) from Drosophila melanogaster, anthropod, worm, and sea cucumber, and similar proteins. Pc is a component of the Polycomb-group (PcG) multiprotein PRC1 complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. The core subunits of PRC1 are polycomb (Pc), polyhomeotic (Ph), posterior sex combs (Psc), and sex comb extra (Sce, also known as dRing). Polycomb (Pc) plays a role in modulating life span in flies, it negatively regulates longevity.


Pssm-ID: 349291  Cd Length: 54  Bit Score: 42.45  E-value: 1.13e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 6755702   43 FEVEYLCDYKKIREQEYYLVKWRGYPDSENTWEPRQNLKCIRVLKQFHK 91
Cdd:cd18644   4 YAAEKILKKRVRKGKVEYLVKWKGWSNKHNTWEPEENILDRRLIEIFER 52
CD_POL_like cd18971
chromodomain of a Magnaporthe grisea putative retrotransposon polyprotein, and similar ...
 43-89 1.87e-05

chromodomain of a Magnaporthe grisea putative retrotransposon polyprotein, and similar proteins; This subgroup includes the CHROMO (CHRromatin Organization Modifier) domain found in a Magnaporthe grisea putative retrotransposon polyprotein which includes domains in the following order: an aspartyl protease, a reverse transcriptase, RNase H, and an integrase, here the chromodomain is found at the C-terminus of the integrase domain. The chromodomain, is a conserved region of about 50 amino acids, found in a variety of chromosomal proteins, and implicated in the binding, of the proteins in which it is found, to methylated histone tails and maybe RNA. A chromodomain may occur as a single instance, in a tandem arrangement, or followed by a related chromo shadow domain.


Pssm-ID: 349327  Cd Length: 50  Bit Score: 41.61  E-value: 1.87e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 6755702   43 FEVEYLCDYKKIREQEY---YLVKWRGYpdSENTWEPRQNLKCIRVLKQF 89
Cdd:cd18971   1 YEVEEILAARRRRIRGKgreVLVKWVGY--AEPTWEPLDNLADTAALDRF 48
chromodomain cd18964
CHROMO (CHRromatin Organization Modifier) domain; uncharacterized subgroup; The chromodomain ...
 51-91 2.72e-05

CHROMO (CHRromatin Organization Modifier) domain; uncharacterized subgroup; The chromodomain is a conserved region of about 50 amino acids, found in a variety of chromosomal proteins. The chromodomain is implicated in the binding, of the proteins in which it is found, to methylated histone tails and maybe RNA. A chromodomain may occur as a single instance, in a tandem arrangement, or followed by a related chromo shadow domain. Chromodomains belong to the chromo-like superfamily of SH3-fold-beta-barrel domains which includes chromo shadow domains and chromo barrel domains. Chromodomains differ from these in that they lack the first strand of the SH3-fold-beta-barrel. This first strand is altered by insertion in the chromo shadow domains, and chromo barrel domains are typical SH3-fold-beta-barrel domains with sequence similarity to the canonical chromo domain.


Pssm-ID: 349320  Cd Length: 54  Bit Score: 41.55  E-value: 2.72e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 6755702   51 YKKIREQEY-YLVKWRGYPDSENTWEPRQNL-KCIRVLKQFHK 91
Cdd:cd18964  12 SARDGPGKFlWLVKWDGYPIEDATWEPPENLgEHAKLIEDFEK 54
CD_MT_like cd18962
chromodomain of a putative Coemansia reversa NRRL 1564 methyltransferase, and similar proteins; ...
 45-91 5.18e-05

chromodomain of a putative Coemansia reversa NRRL 1564 methyltransferase, and similar proteins; This subgroup includes the CHROMO (CHRromatin Organization Modifier) domain found in a Coemansia reversa NRRL 1564 SET (Su(var)3-9, enhancer-of-zeste, trithorax) domain-containing protein, and similar proteins. The SU(VAR)3-9 protein is the main chromocenter-specific histone H3-K9 methyltransferase (HMTase) in Drosophila where it plays a role in heterochromatic gene silencing. A chromodomain is a conserved region of about 50 amino acids, found in a variety of chromosomal proteins, and which appears to play a role in the functional organization of the eukaryotic nucleus. The chromodomain is implicated in the binding, of the proteins in which it is found, to methylated histone tails and maybe RNA. A chromodomain may occur as a single instance, in a tandem arrangement, or followed by a related chromo shadow domain.


Pssm-ID: 349318  Cd Length: 52  Bit Score: 40.63  E-value: 5.18e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 6755702   45 VEYLCDYKKIREQEYYLVKWRGYPDSENTWEPRQNLKCIRVLKQFHK 91
Cdd:cd18962   6 VEAIVNDVLIDGKHMYEVKWEGYPSDHNNWVAEWDLNDKEILRKYNK 52
chromodomain cd18969
CHROMO (CHRromatin Organization Modifier) domain; uncharacterized subgroup; for most members ...
 42-74 6.11e-05

CHROMO (CHRromatin Organization Modifier) domain; uncharacterized subgroup; for most members of this subgroup, the chromodomain is followed by a chromo shadow domain; The chromodomain is a conserved region of about 50 amino acids, found in a variety of chromosomal proteins. The chromodomain is implicated in the binding, of the proteins in which it is found, to methylated histone tails and maybe RNA. A chromodomain may occur as a single instance, in a tandem arrangement, or followed by a related chromo shadow domain. Chromodomains belong to the chromo-like superfamily of SH3-fold-beta-barrel domains which includes chromo shadow domains and chromo barrel domains. Chromodomains differ from these in that they lack the first strand of the SH3-fold-beta-barrel. This first strand is altered by insertion in the chromo shadow domains, and chromo barrel domains are typical SH3-fold-beta-barrel domains with sequence similarity to the canonical chromo domain. For the majority of members of this subgroup, the chromodomain is followed by a chromo shadow domain (CSD).


Pssm-ID: 349325  Cd Length: 56  Bit Score: 40.58  E-value: 6.11e-05
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 6755702   42 DFEVEYL--CDYKKIREQEY-YLVKWRGYPDSENTW 74
Cdd:cd18969   3 EYEIEEIldVKKGGFEDGKLaYFVKWKGYPSSENSW 38
CD_Cbx4 cd18645
chromodomain of chromobox homolog 4; CHRomatin Organization Modifier (chromo) domain of ...
 43-90 7.86e-05

chromodomain of chromobox homolog 4; CHRomatin Organization Modifier (chromo) domain of chromobox homolog 4 (CBX4), a component of the PcG repressive complex PRC1, one of the two classes of PRCs. PcG proteins form large multiprotein complexes (PcG bodies) which are involved in the stable repression of genes involved in development, signaling or cancer via chromatin-based epigenetic modifications. Mammalian PRC1 includes canonical (cPRC1) and non-canonical complexes; cPRC1, contains four core subunits including one CBX protein (CBX2, CBX4, and CBX6-CBX8) that binds H3K27me3. CBX family members have different affinity for H3K27me3, with CBX7 having the highest binding capability. The human CBX proteins show distinct nuclear localizations and contribute differently to transcriptional repression. Some CBX proteins of the PRC1 complex have been implicated in transcriptional activation as well as in PRC1-independent roles in embryonic stem cells and in somatic cells. In addition to a chromodomain with H3K27me3-binding activity, Cbx4 contains two SUMO-interacting motifs responsible for its small ubiquitin-related modifier (SUMO) E3 ligase activity. CBX proteins may act as an oncogene or tumor suppressor in a cell-type-dependent manner, for example CBX8 promotes proliferation while suppressing metastasis, in colorectal carcinoma progression. CBX4 may serve as a tumor suppressor in colorectal carcinoma, and has been shown to be an oncogene in osteosarcoma and breast cancer.


Pssm-ID: 349292  Cd Length: 55  Bit Score: 40.04  E-value: 7.86e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 6755702   43 FEVEYLcDYKKIREQEY-YLVKWRGYPDSENTWEPRQNLKCIRVLKQFH 90
Cdd:cd18645   4 FAVESI-EKKRIRKGRVeYLVKWRGWSPKYNTWEPEENILDPRLLIAFQ 51
CD_Chro-like cd18640
chromodomain of Drosophila melanogaster chromator chromodomain protein, and similar proteins; ...
 60-91 9.94e-05

chromodomain of Drosophila melanogaster chromator chromodomain protein, and similar proteins; This subgroup includes the CHROMO (CHRromatin Organization Modifier) domain found in chromodomain of Drosophila melanogaster chromator (also known as Chriz/Chro) chromodomain protein, and similar proteins. Chromator is a nuclear protein that plays a role in proper spindle dynamics during mitosis. The chromodomain is implicated in the binding, of the proteins in which it is found, to methylated histone tails and maybe RNA. A chromodomain may occur as a single instance, in a tandem arrangement, or followed by a related chromo shadow domain.


Pssm-ID: 349290  Cd Length: 52  Bit Score: 39.97  E-value: 9.94e-05
                        10        20        30
                ....*....|....*....|....*....|...
gi 6755702   60 YLVKWRGYPDSENTWEPRQNL-KCIRVLKQFHK 91
Cdd:cd18640  20 YLVKWENRSHHENTWEPMANLeRCKYLLQMFEK 52
SET_SMYD4 cd10536
SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing ...
 312-365 2.44e-04

SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing protein 4 (SMYD4) and similar proteins; SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. In zebrafish, SMYD4 is ubiquitously expressed in early embryos and becomes enriched in the developing heart; mutants show a strong defect in cardiomyocyte proliferation, which lead to a severe cardiac malformation.


Pssm-ID: 380934 [Multi-domain]  Cd Length: 218  Bit Score: 42.29  E-value: 2.44e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 6755702  312 AAYYGNIShFVNHSCDPNlqVYNVFIDNLderlprIAFFATRTIWAGEELTFDY 365
Cdd:cd10536 145 TAIYPTLS-LLNHSCDPN--TIRSFYGNT------IVVRATRPIKKGEEITICY 189
CD_Cbx8 cd18649
chromodomain of chromobox homolog 8; CHRomatin Organization Modifier (chromo) domain of ...
 43-89 5.61e-04

chromodomain of chromobox homolog 8; CHRomatin Organization Modifier (chromo) domain of chromobox homolog 8 (CBX8), a component of the PcG repressive complex PRC1, one of the two classes of PRCs. PcG proteins form large multiprotein complexes (PcG bodies) which are involved in the stable repression of genes involved in development, signaling or cancer via chromatin-based epigenetic modifications. Mammalian PRC1 includes canonical (cPRC1) and non-canonical complexes; cPRC1, contains four core subunits including one CBX protein (CBX2, CBX4, and CBX6-CBX8) that binds H3K27me3. CBX family members have different affinity for H3K27me3, with CBX7 having the highest binding capability. The human CBX proteins show distinct nuclear localizations and contribute differently to transcriptional repression. Some CBX proteins of the PRC1 complex have been implicated in transcriptional activation as well as in PRC1-independent roles in embryonic stem cells and in somatic cells. CBX proteins may act as an oncogene or tumor suppressor in a cell-type-dependent manner, CBX8 for example promotes proliferation while suppressing metastasis, in colorectal carcinoma progression.


Pssm-ID: 349296  Cd Length: 55  Bit Score: 37.78  E-value: 5.61e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 6755702   43 FEVEYLCDYKKIREQEYYLVKWRGYPDSENTWEPRQNLKCIRVLKQF 89
Cdd:cd18649   5 FAAEALLKRRIRKGRMEYLVKWKGWSQKYSTWEPEENILDARLLAAF 51
CD_Cbx6 cd18648
chromodomain of chromobox homolog 6; CHRomatin Organization Modifier (chromo) domain of ...
 60-96 7.60e-04

chromodomain of chromobox homolog 6; CHRomatin Organization Modifier (chromo) domain of chromobox homolog 6 (CBX6), a component of the PcG repressive complex PRC1, one of the two classes of PRCs. PcG proteins form large multiprotein complexes (PcG bodies) which are involved in the stable repression of genes involved in development, signaling or cancer via chromatin-based epigenetic modifications. Mammalian PRC1 includes canonical (cPRC1) and non-canonical complexes; cPRC1, contains four core subunits including one CBX protein (CBX2, CBX4, and CBX6-CBX8) that binds H3K27me3. CBX family members have different affinity for H3K27me3, with CBX7 having the highest binding capability. The human CBX proteins show distinct nuclear localizations and contribute differently to transcriptional repression. Some CBX proteins of the PRC1 complex have been implicated in transcriptional activation as well as in PRC1-independent roles in embryonic stem cells and in somatic cells.


Pssm-ID: 349295  Cd Length: 58  Bit Score: 37.34  E-value: 7.60e-04
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 6755702   60 YLVKWRGYPDSENTWEPRQNLKCIRVLKQF-HKDLERE 96
Cdd:cd18648  21 YLVKWKGWAIKYSTWEPEENILDSRLIAAFeQKERERE 58
CD_POL_like cd18970
chromodomain of Hypsizygus marmoreus TY3B-I_0 protein, and similar proteins; This subgroup ...
 43-80 1.16e-03

chromodomain of Hypsizygus marmoreus TY3B-I_0 protein, and similar proteins; This subgroup includes the CHROMO (CHRromatin Organization Modifier) domain found in Hypsizygus marmoreus TY3B-I_0 protein, a putative TY3/gypsy retrotransposon polyprotein, and similar proteins. The pol gene in TY3/gypsy elements generally encodes domains in the following order: an aspartyl protease, a reverse transcriptase, RNase H, and an integrase, here the chromodomain is found at the C-terminus of the integrase domain. The chromodomain, is a conserved region of about 50 amino acids, found in a variety of chromosomal proteins, and implicated in the binding, of the proteins in which it is found, to methylated histone tails and maybe RNA. A chromodomain may occur as a single instance, in a tandem arrangement, or followed by a related chromo shadow domain.


Pssm-ID: 349326  Cd Length: 49  Bit Score: 36.65  E-value: 1.16e-03
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 6755702   43 FEVEYLCDYKKIREQEYYLVKWRGYPDSENTWEPRQNL 80
Cdd:cd18970   1 FFVERILDERRRGRGWQYLVRWLGYGPSDDSWLPRREL 38
chromodomain cd18967
CHROMO (CHRromatin Organization Modifier) domain; uncharacterized subgroup; The chromodomain ...
 60-91 1.54e-03

CHROMO (CHRromatin Organization Modifier) domain; uncharacterized subgroup; The chromodomain is a conserved region of about 50 amino acids, found in a variety of chromosomal proteins. The chromodomain is implicated in the binding, of the proteins in which it is found, to methylated histone tails and maybe RNA. A chromodomain may occur as a single instance, in a tandem arrangement, or followed by a related chromo shadow domain. Chromodomains belong to the chromo-like superfamily of SH3-fold-beta-barrel domains which includes chromo shadow domains and chromo barrel domains. Chromodomains differ from these in that they lack the first strand of the SH3-fold-beta-barrel. This first strand is altered by insertion in the chromo shadow domains, and chromo barrel domains are typical SH3-fold-beta-barrel domains with sequence similarity to the canonical chromo domain.


Pssm-ID: 349323  Cd Length: 55  Bit Score: 36.46  E-value: 1.54e-03
                        10        20        30
                ....*....|....*....|....*....|..
gi 6755702   60 YLVKWRGYPDSenTWEPRQNLKCIRVLKQFHK 91
Cdd:cd18967  26 YLTKWEGFPDE--TWEPAESFDDRKILHDYRR 55
CD2_tandem_CHD5-9_like cd18663
repeat 2 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 5-9, ...
 58-91 1.65e-03

repeat 2 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 5-9, and similar proteins; Repeat 2 of tandem CHRomatin Organization Modifier (chromo) domains, found in CHD (chromodomain helicase DNA-binding) proteins such as mammalian helicase DNA-binding proteins CHD5, CHD6, CHD7, CHD8, and CHD9. The CHD proteins belong to the SNF2 superfamily of ATP-dependent chromatin remodelers and contain two signature motifs: a pair of chromodomains located in the N-terminal region, and the SNF2-like ATPase domain located in the central region of the protein. CHD chromatin remodelers are important regulators of transcription and play critical roles during developmental processes. The N-terminal chromodomains of CHD1 have been shown to guard against sliding hexasomes. Mutations in the chromodomains of mouse CHD1 result in nuclear redistribution, suggesting that the chromodomain is essential for proper association with chromatin; also, deletion of the chromodomains in the Drosophila melanogaster CHD3-4 homolog impaired nucleosome binding, mobilization, and ATPase functions. CHD6, CHD7, and CHD8 enzymes have been demonstrated to have different substrate specificities and remodeling activities. A chromodomain is a conserved region of about 50 amino acids, found in a variety of chromosomal proteins, and which appears to play a role in the functional organization of the eukaryotic nucleus. The chromodomain is implicated in the binding, of the proteins in which it is found, to methylated histone tails and maybe RNA. A chromodomain may occur as a single instance, in a tandem arrangement, or followed by a related chromo shadow domain.


Pssm-ID: 349310 [Multi-domain]  Cd Length: 59  Bit Score: 36.50  E-value: 1.65e-03
                        10        20        30
                ....*....|....*....|....*....|....
gi 6755702   58 EYYLVKWRGYPDSENTWEPRQNLKCIRVlKQFHK 91
Cdd:cd18663  25 THYLVKWCSLPYEDSTWELEEDVDPAKI-EEFEK 57
SET_SETD7 cd10530
SET domain found in SET domain-containing protein 7 (SETD7) and similar proteins; SETD7 (EC 2. ...
 273-365 1.73e-03

SET domain found in SET domain-containing protein 7 (SETD7) and similar proteins; SETD7 (EC 2.1.1.43; also termed histone H3-K4 methyltransferase SETD7, H3-K4-HMTase SETD7, lysine N-methyltransferase 7 (KMT7) or SET7/9) is a histone-lysine N-methyltransferase that specifically monomethylates 'Lys-4' of histone H3. It plays a central role in the transcriptional activation of genes such as collagenase or insulin. Set7/9 also methylates non-histone proteins, including estrogen receptor alpha (ERa), suggesting it has a role in diverse biological processes. ERa methylation by Set7/9 stabilizes ERa and activates its transcriptional activities, which are involved in the carcinogenesis of breast cancer. In a high-throughput screen, treatment of human breast cancer cells (MCF7 cells) with cyproheptadine, a Set7/9 inhibitor, decreased the expression and transcriptional activity of ERa, thereby inhibiting estrogen-dependent cell growth.


Pssm-ID: 380928  Cd Length: 130  Bit Score: 38.43  E-value: 1.73e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755702  273 YVGEIITSEEAERRGqiYDRQGATYLFDLDYVEDV---YTVDAAYYGNISHFVNHSCDPNLQvYNVFIDnlderlPRIAF 349
Cdd:cd10530  38 YNGVRITHQEVDSRD--WSLNGNTISLDEETVIDVpepYNSVSKYCASLGHKANHSFTPNCI-YDPFVH------PRFGP 108

                        90       100
                ....*....|....*....|
gi 6755702  350 F----ATRTIWAGEELTFDY 365
Cdd:cd10530 109 IkcirTLRAVEAGEELTVAY 128
CD_Chp1_like cd18636
chromodomain of chromodomain-containing protein 1, and similar proteins; CHRomatin ...
 43-80 1.74e-03

chromodomain of chromodomain-containing protein 1, and similar proteins; CHRomatin Organization Modifier (chromo) domain of chromodomain-containing protein 1 (CHp1), and similar proteins. Chp1 is needed for RNA interference-dependent heterochromatin formation in fission yeast. Chp1 is a member of the RNA-induced transcriptional silencing (RITS) complex which maintains the heterochromatin regions. The chromodomain of the Chp1 component binds the histone H3 lysine 9 methylated tail (H3K9me) and the core of the nucleosome. A chromodomain is a conserved region of about 50 amino acids, found in a variety of chromosomal proteins, and which appears to play a role in the functional organization of the eukaryotic nucleus. The chromodomain is implicated in the binding, of the proteins in which it is found, to methylated histone tails and maybe RNA. A chromodomain may occur as a single instance, in a tandem arrangement, or followed by a related chromo shadow domain.


Pssm-ID: 349286  Cd Length: 52  Bit Score: 36.27  E-value: 1.74e-03
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 6755702   43 FEVE-YLCDYKKIREQEYYLVKWRGYPDSENTWEPRQNL 80
Cdd:cd18636   2 YEVEdILADRVNKNGINEYYIKWAGYDWYDNTWEPEQNL 40
CD_Cbx7 cd18646
chromodomain of chromobox homolog 7; CHRomatin Organization Modifier (chromo) domain of ...
 43-80 3.63e-03

chromodomain of chromobox homolog 7; CHRomatin Organization Modifier (chromo) domain of chromobox homolog 7 (CBX7), a component of the PcG repressive complex PRC1, one of the two classes of PRCs. PcG proteins form large multiprotein complexes (PcG bodies) which are involved in the stable repression of genes involved in development, signaling or cancer via chromatin-based epigenetic modifications. Mammalian PRC1 includes canonical (cPRC1) and non-canonical complexes; cPRC1, contains four core subunits including one CBX protein (CBX2, CBX4, and CBX6-CBX8) that binds H3K27me3. CBX family members have different affinity for H3K27me3, with CBX7 having the highest binding capability. The human CBX proteins show distinct nuclear localizations and contribute differently to transcriptional repression. Some CBX proteins of the PRC1 complex have been implicated in transcriptional activation as well as in PRC1-independent roles in embryonic stem cells and in somatic cells. CBX proteins may act as an oncogene or tumor suppressor in a cell-type-dependent manner, for example CBX8 promotes proliferation while suppressing metastasis, in colorectal carcinoma progression. CBX7 has been shown to function as a tumor suppressor in lung carcinoma and an oncogene in gastric cancer and lymphoma.


Pssm-ID: 349293  Cd Length: 56  Bit Score: 35.45  E-value: 3.63e-03
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 6755702   43 FEVEYLCDYKKIREQEYYLVKWRGYPDSENTWEPRQNL 80
Cdd:cd18646   5 FAVESIRKKRVRKGKVEYLVKWKGWPPKYSTWEPEEHI 42
CD1_tandem_CHD1_yeast_like cd18665
repeat 1 of the paired tandem chromodomains of yeast chromodomain helicase DNA-binding protein ...
 53-87 4.24e-03

repeat 1 of the paired tandem chromodomains of yeast chromodomain helicase DNA-binding protein 1, and similar proteins; Repeat 1 of tandem CHRomatin Organization Modifier (chromo) domains, found in CHD (chromodomain helicase DNA-binding) proteins such as yeast protein CHD1. The CHD proteins belong to the SNF2 superfamily of ATP-dependent chromatin remodelers and contain two signature motifs: a pair of chromodomains located in the N-terminal region, and the SNF2-like ATPase domain located in the central region of the protein. CHD chromatin remodelers are important regulators of transcription and play critical roles during developmental processes. The N-terminal chromodomains of CHD1 have been shown to guard against sliding hexasomes. Mutations in the chromodomains of mouse CHD1 result in nuclear redistribution, suggesting that the chromodomain is essential for proper association with chromatin; also, deletion of the chromodomains in the Drosophila melanogaster CHD3-4 homolog impaired nucleosome binding, mobilization, and ATPase functions. A chromodomain is a conserved region of about 50 amino acids, found in a variety of chromosomal proteins, and which appears to play a role in the functional organization of the eukaryotic nucleus. The chromodomain is implicated in the binding, of the proteins in which it is found, to methylated histone tails and maybe RNA. A chromodomain may occur as a single instance, in a tandem arrangement, or followed by a related chromo shadow domain.


Pssm-ID: 349312  Cd Length: 65  Bit Score: 35.44  E-value: 4.24e-03
                        10        20        30
                ....*....|....*....|....*....|....*
gi 6755702   53 KIREQEYYLVKWRGYPDSENTWEPRQNLKCIRVLK 87
Cdd:cd18665  24 DPKENYEFLIKWTDESHLHNTWETYESLKQVRGLK 58
CD2_tandem cd18659
repeat 2 of paired tandem chromodomains; Repeat 2 of tandem CHRomatin Organization Modifier ...
 56-81 5.16e-03

repeat 2 of paired tandem chromodomains; Repeat 2 of tandem CHRomatin Organization Modifier (chromo) domains, found in CHD (chromodomain helicase DNA-binding) proteins such as mammalian helicase DNA-binding proteins CHD1 to CHD9, and yeast protein CHD1. The CHD proteins belong to the SNF2 superfamily of ATP-dependent chromatin remodelers and contain two signature motifs: a pair of chromodomains located in the N-terminal region, and the SNF2-like ATPase domain located in the central region of the protein. CHD chromatin remodelers are important regulators of transcription and play critical roles during developmental processes. The N-terminal chromodomains of CHD1 have been shown to guard against sliding hexasomes. Mutations in the chromodomains of mouse CHD1 result in nuclear redistribution, suggesting that the chromodomain is essential for proper association with chromatin; also, deletion of the chromodomains in the Drosophila melanogaster CHD3-4 homolog impaired nucleosome binding, mobilization, and ATPase functions. A chromodomain is a conserved region of about 50 amino acids, found in a variety of chromosomal proteins, and which appears to play a role in the functional organization of the eukaryotic nucleus. The chromodomain is implicated in the binding, of the proteins in which it is found, to methylated histone tails and maybe RNA. A chromodomain may occur as a single instance, in a tandem arrangement, or followed by a related chromo shadow domain.


Pssm-ID: 349306 [Multi-domain]  Cd Length: 54  Bit Score: 34.86  E-value: 5.16e-03
                        10        20
                ....*....|....*....|....*.
gi 6755702   56 EQEYYLVKWRGYPDSENTWEPRQNLK 81
Cdd:cd18659  17 GVTEYLVKWKGLPYDECTWESEEDIS 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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