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Conserved domains on  [gi|170763506|ref|NP_036219|]
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general transcription factor 3C polypeptide 5 isoform 2 [Homo sapiens]

Protein Classification

TFIIIC subunit 5 family protein( domain architecture ID 16049258)

TFIIIC subunit 5 family protein similar to Homo sapiens general transcription factor 3C polypeptide 5 (GTF3C5) involved in RNA polymerase III-mediated transcription

Gene Ontology:  GO:0003677|GO:0000127|GO:0006383

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tau95 pfam09734
RNA polymerase III transcription factor (TF)IIIC subunit HTH domain; TFIIIC1 is a multisubunit ...
 168-322 9.55e-57

RNA polymerase III transcription factor (TF)IIIC subunit HTH domain; TFIIIC1 is a multisubunit DNA binding factor that serves as a dynamic platform for assembly of pre-initiation complexes on class III genes. This entry represents the tau 95 subunit which holds a key position in TFIIIC, exerting both upstream and downstream influence on the TFIIIC-DNA complex by rendering the complex more stable. Once bound to tDNA-intragenic promoter elements, TFIIIC directs the assembly of TFIIIB on the DNA, which in turn recruits the RNA polymerase III (pol III) and activates multiple rounds of transcription.


:

Pssm-ID: 462865  Cd Length: 151  Bit Score: 186.34  E-value: 9.55e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170763506  168 IPPPIFSRLDAPVDYFYRPETQHREGynnpPISGENLIGLSRARRPHNAIFVNFEDEE-VPKQPLEAAAQTWRRvctNPV 246
Cdd:pfam09734   2 LPPPLFSRIDLPFNYNYRQNPAVKVV----KESGELRLVNTRKSRKLHTIFVNFDDEEpVPTEPPPELLKELKS---KPI 74

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 170763506  247 DRKVEEELRKLFDIRPIWSRNAVKANISVHPDK-LKVLLPFIAYYMITGPWRSLWIRFGYDPRKNPDAKIYQVLDFR 322
Cdd:pfam09734  75 LQRAIEELKKLFEERPIWTRRALLNRLPKKGRHlLKQALPYVAYYFKSGPWRDTWVRFGYDPRKDPEYRIYQTLDFR 151
Tau95_N pfam17682
Tau95 Triple barrel domain; TFIIIC1 is a multisubunit DNA binding factor that serves as a ...
 25-132 1.34e-38

Tau95 Triple barrel domain; TFIIIC1 is a multisubunit DNA binding factor that serves as a dynamic platform for assembly of pre-initiation complexes on class III genes. This entry represents the tau 95 subunit which holds a key position in TFIIIC, exerting both upstream and downstream influence on the TFIIIC-DNA complex by rendering the complex more stable. Once bound to tDNA-intragenic promoter elements, TFIIIC directs the assembly of TFIIIB on the DNA, which in turn recruits the RNA polymerase III (pol III) and activates multiple rounds of transcription.


:

Pssm-ID: 465457  Cd Length: 115  Bit Score: 136.58  E-value: 1.34e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170763506   25 VCVEYPGVVRDVAKMLPTLGGEEGVSRIYADPTKR-LELYFRPKDPYCHPVCANRFSTSSLLLRIRKRTRRQK------G 97
Cdd:pfam17682   1 VSVEYPGIVKNVDRAIETLGGIEKISKALKSSSPRpLELRLRPEDPFSHPIQGDNAPTNNLLLKVTVPKRTGRkrkdprA 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 170763506   98 VLGTEAHSEVTFDMEILGIISTIYKFQGMSDFQYL 132
Cdd:pfam17682  81 LLRKLRDNAGKYSVEPVGIINKTHRFRGMADFQYS 115
 
Name Accession Description Interval E-value
Tau95 pfam09734
RNA polymerase III transcription factor (TF)IIIC subunit HTH domain; TFIIIC1 is a multisubunit ...
 168-322 9.55e-57

RNA polymerase III transcription factor (TF)IIIC subunit HTH domain; TFIIIC1 is a multisubunit DNA binding factor that serves as a dynamic platform for assembly of pre-initiation complexes on class III genes. This entry represents the tau 95 subunit which holds a key position in TFIIIC, exerting both upstream and downstream influence on the TFIIIC-DNA complex by rendering the complex more stable. Once bound to tDNA-intragenic promoter elements, TFIIIC directs the assembly of TFIIIB on the DNA, which in turn recruits the RNA polymerase III (pol III) and activates multiple rounds of transcription.


Pssm-ID: 462865  Cd Length: 151  Bit Score: 186.34  E-value: 9.55e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170763506  168 IPPPIFSRLDAPVDYFYRPETQHREGynnpPISGENLIGLSRARRPHNAIFVNFEDEE-VPKQPLEAAAQTWRRvctNPV 246
Cdd:pfam09734   2 LPPPLFSRIDLPFNYNYRQNPAVKVV----KESGELRLVNTRKSRKLHTIFVNFDDEEpVPTEPPPELLKELKS---KPI 74

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 170763506  247 DRKVEEELRKLFDIRPIWSRNAVKANISVHPDK-LKVLLPFIAYYMITGPWRSLWIRFGYDPRKNPDAKIYQVLDFR 322
Cdd:pfam09734  75 LQRAIEELKKLFEERPIWTRRALLNRLPKKGRHlLKQALPYVAYYFKSGPWRDTWVRFGYDPRKDPEYRIYQTLDFR 151
Tau95_N pfam17682
Tau95 Triple barrel domain; TFIIIC1 is a multisubunit DNA binding factor that serves as a ...
 25-132 1.34e-38

Tau95 Triple barrel domain; TFIIIC1 is a multisubunit DNA binding factor that serves as a dynamic platform for assembly of pre-initiation complexes on class III genes. This entry represents the tau 95 subunit which holds a key position in TFIIIC, exerting both upstream and downstream influence on the TFIIIC-DNA complex by rendering the complex more stable. Once bound to tDNA-intragenic promoter elements, TFIIIC directs the assembly of TFIIIB on the DNA, which in turn recruits the RNA polymerase III (pol III) and activates multiple rounds of transcription.


Pssm-ID: 465457  Cd Length: 115  Bit Score: 136.58  E-value: 1.34e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170763506   25 VCVEYPGVVRDVAKMLPTLGGEEGVSRIYADPTKR-LELYFRPKDPYCHPVCANRFSTSSLLLRIRKRTRRQK------G 97
Cdd:pfam17682   1 VSVEYPGIVKNVDRAIETLGGIEKISKALKSSSPRpLELRLRPEDPFSHPIQGDNAPTNNLLLKVTVPKRTGRkrkdprA 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 170763506   98 VLGTEAHSEVTFDMEILGIISTIYKFQGMSDFQYL 132
Cdd:pfam17682  81 LLRKLRDNAGKYSVEPVGIINKTHRFRGMADFQYS 115
 
Name Accession Description Interval E-value
Tau95 pfam09734
RNA polymerase III transcription factor (TF)IIIC subunit HTH domain; TFIIIC1 is a multisubunit ...
 168-322 9.55e-57

RNA polymerase III transcription factor (TF)IIIC subunit HTH domain; TFIIIC1 is a multisubunit DNA binding factor that serves as a dynamic platform for assembly of pre-initiation complexes on class III genes. This entry represents the tau 95 subunit which holds a key position in TFIIIC, exerting both upstream and downstream influence on the TFIIIC-DNA complex by rendering the complex more stable. Once bound to tDNA-intragenic promoter elements, TFIIIC directs the assembly of TFIIIB on the DNA, which in turn recruits the RNA polymerase III (pol III) and activates multiple rounds of transcription.


Pssm-ID: 462865  Cd Length: 151  Bit Score: 186.34  E-value: 9.55e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170763506  168 IPPPIFSRLDAPVDYFYRPETQHREGynnpPISGENLIGLSRARRPHNAIFVNFEDEE-VPKQPLEAAAQTWRRvctNPV 246
Cdd:pfam09734   2 LPPPLFSRIDLPFNYNYRQNPAVKVV----KESGELRLVNTRKSRKLHTIFVNFDDEEpVPTEPPPELLKELKS---KPI 74

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 170763506  247 DRKVEEELRKLFDIRPIWSRNAVKANISVHPDK-LKVLLPFIAYYMITGPWRSLWIRFGYDPRKNPDAKIYQVLDFR 322
Cdd:pfam09734  75 LQRAIEELKKLFEERPIWTRRALLNRLPKKGRHlLKQALPYVAYYFKSGPWRDTWVRFGYDPRKDPEYRIYQTLDFR 151
Tau95_N pfam17682
Tau95 Triple barrel domain; TFIIIC1 is a multisubunit DNA binding factor that serves as a ...
 25-132 1.34e-38

Tau95 Triple barrel domain; TFIIIC1 is a multisubunit DNA binding factor that serves as a dynamic platform for assembly of pre-initiation complexes on class III genes. This entry represents the tau 95 subunit which holds a key position in TFIIIC, exerting both upstream and downstream influence on the TFIIIC-DNA complex by rendering the complex more stable. Once bound to tDNA-intragenic promoter elements, TFIIIC directs the assembly of TFIIIB on the DNA, which in turn recruits the RNA polymerase III (pol III) and activates multiple rounds of transcription.


Pssm-ID: 465457  Cd Length: 115  Bit Score: 136.58  E-value: 1.34e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170763506   25 VCVEYPGVVRDVAKMLPTLGGEEGVSRIYADPTKR-LELYFRPKDPYCHPVCANRFSTSSLLLRIRKRTRRQK------G 97
Cdd:pfam17682   1 VSVEYPGIVKNVDRAIETLGGIEKISKALKSSSPRpLELRLRPEDPFSHPIQGDNAPTNNLLLKVTVPKRTGRkrkdprA 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 170763506   98 VLGTEAHSEVTFDMEILGIISTIYKFQGMSDFQYL 132
Cdd:pfam17682  81 LLRKLRDNAGKYSVEPVGIINKTHRFRGMADFQYS 115
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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