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Conserved domains on  [gi|6912586|ref|NP_036220|]
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6-phosphogluconolactonase [Homo sapiens]

Protein Classification

6-phosphogluconolactonase( domain architecture ID 10796786)

6-phosphogluconolactonase catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate, which is the the second step of the oxidative phase of the pentose phosphate pathway

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
pgl TIGR01198
6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a ...
 11-248 8.95e-103

6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a part of a multifunctional protein with [Energy metabolism, Pentose phosphate pathway]


:

Pssm-ID: 273494 [Multi-domain]  Cd Length: 233  Bit Score: 298.13  E-value: 8.95e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912586     11 VFSSSQELGAALAQLVAQRAACCLAgARARFALGLSGGSLVSMLARELPAAVApagpaSLARWTLGFCDERLVPFDHAES 90
Cdd:TIGR01198   1 VFSNSAELAEALAERIATKLQTALA-ERGQFSLALSGGRSPIALLEALAAQPL-----DWSRIHLFLGDERYVPLDHADS 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912586     91 TYGLYRTHLLSRLPIPESQVITINPELP-VEEAAEDYAKKLRQAFQGDSIPVFDLLILGVGPDGHTCSLFPDHPLLQERE 169
Cdd:TIGR01198  75 NTGLAREALLDRVAIPASNIHPMPTELSdIEEAAELYEQELAAAFQPIVFPVFDLLLLGMGPDGHTASLFPHTPALQETE 154

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6912586    170 KIVAPISDSPKPPPQRVTLTLPVLNAARTVIFVATGEGKAAVLKRILEDQEENPLPAALVQPHTGKLCWFLDEAAARLL 248
Cdd:TIGR01198 155 RLVTVLTKSPKPPHERITLTLPAINAARKVFLLIAGEEKRNALAEALAVEAEPYPLPAAGVLHSGKTLWLLDYAAARKL 233
 
Name Accession Description Interval E-value
pgl TIGR01198
6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a ...
 11-248 8.95e-103

6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a part of a multifunctional protein with [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273494 [Multi-domain]  Cd Length: 233  Bit Score: 298.13  E-value: 8.95e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912586     11 VFSSSQELGAALAQLVAQRAACCLAgARARFALGLSGGSLVSMLARELPAAVApagpaSLARWTLGFCDERLVPFDHAES 90
Cdd:TIGR01198   1 VFSNSAELAEALAERIATKLQTALA-ERGQFSLALSGGRSPIALLEALAAQPL-----DWSRIHLFLGDERYVPLDHADS 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912586     91 TYGLYRTHLLSRLPIPESQVITINPELP-VEEAAEDYAKKLRQAFQGDSIPVFDLLILGVGPDGHTCSLFPDHPLLQERE 169
Cdd:TIGR01198  75 NTGLAREALLDRVAIPASNIHPMPTELSdIEEAAELYEQELAAAFQPIVFPVFDLLLLGMGPDGHTASLFPHTPALQETE 154

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6912586    170 KIVAPISDSPKPPPQRVTLTLPVLNAARTVIFVATGEGKAAVLKRILEDQEENPLPAALVQPHTGKLCWFLDEAAARLL 248
Cdd:TIGR01198 155 RLVTVLTKSPKPPHERITLTLPAINAARKVFLLIAGEEKRNALAEALAVEAEPYPLPAAGVLHSGKTLWLLDYAAARKL 233
6PGL cd01400
6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the ...
 16-240 4.53e-96

6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard against the accumulation of the delta form of the lactone, which may be toxic through its reaction with endogenous cellular nucleophiles.


Pssm-ID: 238694 [Multi-domain]  Cd Length: 219  Bit Score: 280.60  E-value: 4.53e-96
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912586   16 QELGAALAQLVAQRAACCLAgARARFALGLSGGSLVSMLARELPAAVAPAGpaslARWTLGFCDERLVPFDHAESTYGLY 95
Cdd:cd01400   1 EALAEALADRIAEALAAAIA-KRGRFSLALSGGSTPKPLYELLAAAPALDW----SKVHVFLGDERCVPPDDPDSNYRLA 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912586   96 RTHLLSRLPIPESQVITINPELPVEEAAEDYAKKLRQAFqgDSIPVFDLLILGVGPDGHTCSLFPDHP-LLQEREKIVAP 174
Cdd:cd01400  76 REALLSHVAIPAANIHPIPTELGPEDAAAAYEKELRALF--GGVPPFDLVLLGMGPDGHTASLFPGHPaLLEETDRLVVA 153

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6912586  175 ISDSPKPPPQRVTLTLPVLNAARTVIFVATGEGKAAVLKRILEDQEENPLPAALVQPHTGKLCWFL 240
Cdd:cd01400 154 VTDSPKPPPERITLTLPVLNNARRVVFLVTGAEKAEALKRALAGPDPEELPAARVLPRPGEVLWFL 219
Glucosamine_iso pfam01182
Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;
13-238 2.75e-93

Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;


Pssm-ID: 460101 [Multi-domain]  Cd Length: 222  Bit Score: 273.73  E-value: 2.75e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912586     13 SSSQELGAALAQLVAQRAACCLAgARARFALGLSGGSLVSMLARELPAAVAPAgpaSLARWTLGFCDERLVPFDHAESTY 92
Cdd:pfam01182   1 PDAEALAQALAERLAEALEAALA-ERGRFTLALSGGSTPKPLYELLAAAPARL---DWSRVHVFWGDERCVPPDDPDSNY 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912586     93 GLYRTHLLSRLPIPESQVITIN-PELPVEEAAEDYAKKLRQAFQGDSIPVFDLLILGVGPDGHTCSLFPDHPLLQEREKI 171
Cdd:pfam01182  77 GMAREALLSHVPIPASNVHPIPaSAADPEEAAAAYEAELRELLPDLELPVFDLVLLGMGPDGHTASLFPGSPALEETDRL 156

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6912586    172 VAPISDSPKPPPQRVTLTLPVLNAARTVIFVATGEGKAAVLKRILEDqEENPLPAALVQPHTGKLCW 238
Cdd:pfam01182 157 VVAVTDSPKPPPERITLTLPVLNAARRVWFLVTGAGKADALRRALAG-DPDPLPAALVRPGAGETVW 222
PLN02360 PLN02360
probable 6-phosphogluconolactonase
 7-248 9.82e-70

probable 6-phosphogluconolactonase


Pssm-ID: 166001 [Multi-domain]  Cd Length: 268  Bit Score: 215.49  E-value: 9.82e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912586     7 GLISVFSSSQELGAALAQLVAQRAACCLAgARARFALGLSGGSLVSMLARelPAAVAPAGPASLARWTLGFCDERLVPFD 86
Cdd:PLN02360  11 GEIRVHENLDELSTDLAEYIAELSEASVK-ERGVFAIALSGGSLISFMGK--LCEAPYNKTVDWAKWYIFWADERVVAKN 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912586    87 HAESTYGLYRTHLLSRLPIPESQVITINPELPVEEAAEDYAKKLRQAFQGDSI--------PVFDLLILGVGPDGHTCSL 158
Cdd:PLN02360  88 HADSNYKLAKDGLLSKVPVVPSHVYSINDTVTAEEAATDYEFAIRQLVKTRTIgvsdisdcPKFDLILLGMGSDGHVASL 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912586   159 FPDHPLLQEREKIVAPISDSPKPPPQRVTLTLPVLNAARTVIFVATGEGKAAVLKRILEDQEENP----LPAALVQPHTG 234
Cdd:PLN02360 168 FPNHPALEEKDDWVTFITDSPKPPPERITFTLPVINSASNVAVVATGESKANAVHLAIDDVTEGPdapsLPARMVQPTKG 247

                        250
                 ....*....|....
gi 6912586   235 KLCWFLDEAAARLL 248
Cdd:PLN02360 248 KLVWFLDKPAASKL 261
NagB COG0363
6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport ...
 9-249 3.76e-69

6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440132 [Multi-domain]  Cd Length: 248  Bit Score: 213.48  E-value: 3.76e-69
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912586    9 ISVFSSSQELGAALAQLVAQRAACCLAgARARFALGLSGGS--------LVSMLARElpaavapagPASLARWTLGFCDE 80
Cdd:COG0363   4 VIIFPDAEELAAAAAERAAERIAEAIA-EKGRAVLGLAGGStplglyeeLARLHKEG---------GLDWSRVHVFNLDE 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912586   81 RL-VPFDHAESTYGLYRTHLLSRLPIPESQVITINPELP-VEEAAEDYAKKLRQAfqgdsiPVFDLLILGVGPDGHTCSL 158
Cdd:COG0363  74 YVgLPPDHPQSNRRFMREALLDHVDIPPENIHIPDGEAEdPEAAAARYEALIAEA------GGIDLQLLGIGEDGHIAFN 147

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912586  159 FPDHPLLQEREKIVAP-----------ISDSPKPPPQRVTLTLPVLNAARTVIFVATGEGKAAVLKRILEDQEENPLPAA 227
Cdd:COG0363 148 FPGSPFLSETDRVVTLdestrqanarfFGSIPKVPPQAITLGIPTIMKAREILLLATGENKAEAVAAALEGPVTEEVPAS 227

                       250       260
                ....*....|....*....|..
gi 6912586  228 LVQPHtGKLCWFLDEAAARLLT 249
Cdd:COG0363 228 ILQGH-PNVTWFLDEAAASLLT 248
 
Name Accession Description Interval E-value
pgl TIGR01198
6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a ...
 11-248 8.95e-103

6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a part of a multifunctional protein with [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273494 [Multi-domain]  Cd Length: 233  Bit Score: 298.13  E-value: 8.95e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912586     11 VFSSSQELGAALAQLVAQRAACCLAgARARFALGLSGGSLVSMLARELPAAVApagpaSLARWTLGFCDERLVPFDHAES 90
Cdd:TIGR01198   1 VFSNSAELAEALAERIATKLQTALA-ERGQFSLALSGGRSPIALLEALAAQPL-----DWSRIHLFLGDERYVPLDHADS 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912586     91 TYGLYRTHLLSRLPIPESQVITINPELP-VEEAAEDYAKKLRQAFQGDSIPVFDLLILGVGPDGHTCSLFPDHPLLQERE 169
Cdd:TIGR01198  75 NTGLAREALLDRVAIPASNIHPMPTELSdIEEAAELYEQELAAAFQPIVFPVFDLLLLGMGPDGHTASLFPHTPALQETE 154

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6912586    170 KIVAPISDSPKPPPQRVTLTLPVLNAARTVIFVATGEGKAAVLKRILEDQEENPLPAALVQPHTGKLCWFLDEAAARLL 248
Cdd:TIGR01198 155 RLVTVLTKSPKPPHERITLTLPAINAARKVFLLIAGEEKRNALAEALAVEAEPYPLPAAGVLHSGKTLWLLDYAAARKL 233
6PGL cd01400
6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the ...
 16-240 4.53e-96

6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard against the accumulation of the delta form of the lactone, which may be toxic through its reaction with endogenous cellular nucleophiles.


Pssm-ID: 238694 [Multi-domain]  Cd Length: 219  Bit Score: 280.60  E-value: 4.53e-96
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912586   16 QELGAALAQLVAQRAACCLAgARARFALGLSGGSLVSMLARELPAAVAPAGpaslARWTLGFCDERLVPFDHAESTYGLY 95
Cdd:cd01400   1 EALAEALADRIAEALAAAIA-KRGRFSLALSGGSTPKPLYELLAAAPALDW----SKVHVFLGDERCVPPDDPDSNYRLA 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912586   96 RTHLLSRLPIPESQVITINPELPVEEAAEDYAKKLRQAFqgDSIPVFDLLILGVGPDGHTCSLFPDHP-LLQEREKIVAP 174
Cdd:cd01400  76 REALLSHVAIPAANIHPIPTELGPEDAAAAYEKELRALF--GGVPPFDLVLLGMGPDGHTASLFPGHPaLLEETDRLVVA 153

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6912586  175 ISDSPKPPPQRVTLTLPVLNAARTVIFVATGEGKAAVLKRILEDQEENPLPAALVQPHTGKLCWFL 240
Cdd:cd01400 154 VTDSPKPPPERITLTLPVLNNARRVVFLVTGAEKAEALKRALAGPDPEELPAARVLPRPGEVLWFL 219
Glucosamine_iso pfam01182
Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;
13-238 2.75e-93

Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;


Pssm-ID: 460101 [Multi-domain]  Cd Length: 222  Bit Score: 273.73  E-value: 2.75e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912586     13 SSSQELGAALAQLVAQRAACCLAgARARFALGLSGGSLVSMLARELPAAVAPAgpaSLARWTLGFCDERLVPFDHAESTY 92
Cdd:pfam01182   1 PDAEALAQALAERLAEALEAALA-ERGRFTLALSGGSTPKPLYELLAAAPARL---DWSRVHVFWGDERCVPPDDPDSNY 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912586     93 GLYRTHLLSRLPIPESQVITIN-PELPVEEAAEDYAKKLRQAFQGDSIPVFDLLILGVGPDGHTCSLFPDHPLLQEREKI 171
Cdd:pfam01182  77 GMAREALLSHVPIPASNVHPIPaSAADPEEAAAAYEAELRELLPDLELPVFDLVLLGMGPDGHTASLFPGSPALEETDRL 156

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6912586    172 VAPISDSPKPPPQRVTLTLPVLNAARTVIFVATGEGKAAVLKRILEDqEENPLPAALVQPHTGKLCW 238
Cdd:pfam01182 157 VVAVTDSPKPPPERITLTLPVLNAARRVWFLVTGAGKADALRRALAG-DPDPLPAALVRPGAGETVW 222
PLN02360 PLN02360
probable 6-phosphogluconolactonase
 7-248 9.82e-70

probable 6-phosphogluconolactonase


Pssm-ID: 166001 [Multi-domain]  Cd Length: 268  Bit Score: 215.49  E-value: 9.82e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912586     7 GLISVFSSSQELGAALAQLVAQRAACCLAgARARFALGLSGGSLVSMLARelPAAVAPAGPASLARWTLGFCDERLVPFD 86
Cdd:PLN02360  11 GEIRVHENLDELSTDLAEYIAELSEASVK-ERGVFAIALSGGSLISFMGK--LCEAPYNKTVDWAKWYIFWADERVVAKN 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912586    87 HAESTYGLYRTHLLSRLPIPESQVITINPELPVEEAAEDYAKKLRQAFQGDSI--------PVFDLLILGVGPDGHTCSL 158
Cdd:PLN02360  88 HADSNYKLAKDGLLSKVPVVPSHVYSINDTVTAEEAATDYEFAIRQLVKTRTIgvsdisdcPKFDLILLGMGSDGHVASL 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912586   159 FPDHPLLQEREKIVAPISDSPKPPPQRVTLTLPVLNAARTVIFVATGEGKAAVLKRILEDQEENP----LPAALVQPHTG 234
Cdd:PLN02360 168 FPNHPALEEKDDWVTFITDSPKPPPERITFTLPVINSASNVAVVATGESKANAVHLAIDDVTEGPdapsLPARMVQPTKG 247

                        250
                 ....*....|....
gi 6912586   235 KLCWFLDEAAARLL 248
Cdd:PLN02360 248 KLVWFLDKPAASKL 261
NagB COG0363
6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport ...
 9-249 3.76e-69

6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440132 [Multi-domain]  Cd Length: 248  Bit Score: 213.48  E-value: 3.76e-69
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912586    9 ISVFSSSQELGAALAQLVAQRAACCLAgARARFALGLSGGS--------LVSMLARElpaavapagPASLARWTLGFCDE 80
Cdd:COG0363   4 VIIFPDAEELAAAAAERAAERIAEAIA-EKGRAVLGLAGGStplglyeeLARLHKEG---------GLDWSRVHVFNLDE 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912586   81 RL-VPFDHAESTYGLYRTHLLSRLPIPESQVITINPELP-VEEAAEDYAKKLRQAfqgdsiPVFDLLILGVGPDGHTCSL 158
Cdd:COG0363  74 YVgLPPDHPQSNRRFMREALLDHVDIPPENIHIPDGEAEdPEAAAARYEALIAEA------GGIDLQLLGIGEDGHIAFN 147

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912586  159 FPDHPLLQEREKIVAP-----------ISDSPKPPPQRVTLTLPVLNAARTVIFVATGEGKAAVLKRILEDQEENPLPAA 227
Cdd:COG0363 148 FPGSPFLSETDRVVTLdestrqanarfFGSIPKVPPQAITLGIPTIMKAREILLLATGENKAEAVAAALEGPVTEEVPAS 227

                       250       260
                ....*....|....*....|..
gi 6912586  228 LVQPHtGKLCWFLDEAAARLLT 249
Cdd:COG0363 228 ILQGH-PNVTWFLDEAAASLLT 248
GlcN6P_deaminase cd01399
GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase ...
 16-248 3.22e-22

GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or deamination. It is the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate (GlcNAc6P). GlcN6P deaminase is a hexameric enzyme that is allosterically activated by GlcNAc6P.


Pssm-ID: 238693 [Multi-domain]  Cd Length: 232  Bit Score: 91.39  E-value: 3.22e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912586   16 QELGAALAQLVAQRAAcclagARARFALGLSGGS--------LVSMLARElpaavapagPASLARWTLGFCDERL-VPFD 86
Cdd:cd01399   1 EEMSEAAAELIAELIR-----EKPPAVLGLATGStplgvyeeLIELHKEG---------GLSFSNVTTFNLDEYVgLPPD 66

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912586   87 HAESTYGLYRTHLLSRLPIPESQVITINPELP-VEEAAEDYAKKLRQAfqgDSIpvfDLLILGVGPDGHTCslF--PDHP 163
Cdd:cd01399  67 HPQSYHYFMRENLFDHIDIKPENIHIPDGNAAdLEAECRRYEALIAEA---GGI---DLQLLGIGENGHIG--FnePGSS 138

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912586  164 L--------LQEREKIV-APISDSP-KPPPQRVTLTLPVLNAARTVIFVATGEGKAAVLKRILEDQEENPLPAALVQPHT 233
Cdd:cd01399 139 LdsrtrvvtLDESTRQAnARFFDGDeDVPTQAITMGIGTIMKAKEILLLATGEGKAEAVKKALEGPVTEECPASILQLHP 218

                       250
                ....*....|....*
gi 6912586  234 gKLCWFLDEAAARLL 248
Cdd:cd01399 219 -NVTVILDEAAASEL 232
nagB PRK00443
glucosamine-6-phosphate deaminase; Provisional
 9-250 1.50e-16

glucosamine-6-phosphate deaminase; Provisional


Pssm-ID: 179028 [Multi-domain]  Cd Length: 261  Bit Score: 76.79  E-value: 1.50e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912586     9 ISVFSSSQELGAALAQLVAQRAACCLAGARARFALGL-SGGSLVSMLArELPAAVAPAGPaSLARWTLGFCDERL-VPFD 86
Cdd:PRK00443   3 LIILKTAEEVGKWAARHIANRINAFLPTKERPFVLGLaTGSSPLETYK-ALIELHKAGKV-DFSRVTTFNLDEYVgLPAD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912586    87 HAESTYGLYRTHLLSRLPIPESQVITINPELP-VEEAAEDYAKKLRQAFqgdsiPVfDLLILGVGPDGH------TCSLf 159
Cdd:PRK00443  81 HPESYRYFMRENFFDHVDIPPENINLLNGNAPdPEAECRRYEEKIKSAG-----GI-DLQILGIGENGHiafnepGSSF- 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912586   160 pDHP----LLQEREKIV------APISDSPKpppQRVTLTLPVLNAARTVIFVATGEGKAAVLKRILEDQEENPLPAALV 229
Cdd:PRK00443 154 -ASRtrikTLTEDTRIAnsrffdGDIEQVPK---YALTVGVGTILDAKEIMLLAPGHNKAEAVKAAVEGPVNHMWPASIL 229

                        250       260
                 ....*....|....*....|.
gi 6912586   230 QPHTgKLCWFLDEAAARLLTV 250
Cdd:PRK00443 230 QLHP-KATLVLDEAAASELKV 249
PRK12358 PRK12358
glucosamine-6-phosphate deaminase;
79-248 1.96e-12

glucosamine-6-phosphate deaminase;


Pssm-ID: 183470  Cd Length: 239  Bit Score: 64.77  E-value: 1.96e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912586    79 DErlVPFDHAES---TYGLYRTHLLSRLPIPESQVitinPELPVEEAAEdYAKKLRQAfqGDsipvFDLLILGVGPDGHT 155
Cdd:PRK12358  66 DE--IPFRGKEGegvTITNLRNLFFTPAGIKEENI----HKLTIDNYRE-HDQKLARD--GG----LDLVVLGLGADGHF 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912586   156 CSLFPDH----------PLLQEREKIVAPI---SDSPKPPPQRVTLTLPVLNAARTVIFVATGEGKAAVLKRILEDQEEN 222
Cdd:PRK12358 133 CGNLPGTthfhdetvevPIQGEMVDIVAHGelgGDFSLVPDSYVTMGPKSIMAAKNLLLIVNGKGKAQILKKVLQGPVTE 212

                        170       180
                 ....*....|....*....|....*.
gi 6912586   223 PLPAALVQPHTgKLCWFLDEAAARLL 248
Cdd:PRK12358 213 DVPASILQLHP-NLTVILDEAAAAEL 237
PTZ00285 PTZ00285
glucosamine-6-phosphate isomerase; Provisional
 84-250 2.39e-12

glucosamine-6-phosphate isomerase; Provisional


Pssm-ID: 140308  Cd Length: 253  Bit Score: 64.78  E-value: 2.39e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912586    84 PFDHAESTYGLYRTHLLSRLPIPESQVITINPELP-VEEAAEDYAKKLRqafqgdSIPVFDLLILGVGPDGHTCSLFPDH 162
Cdd:PTZ00285  78 PRDHPQSYHYFMKENFFDHVDIKEENRHILNGTAPdLEEECRRYEEKIR------AVGGIDLFLAGIGTDGHIAFNEPGS 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912586   163 PLLQE-------REKIVAPI----SDSPKPPPQRVTLTLPVLNAARTVIFVATGEGKAAVLKRILEDQEENPLPAALVQP 231
Cdd:PTZ00285 152 SLDSRtrvkslnQETIDANArffgNDISKVPTMALTVGIRTIMEAREVLLLATGASKAIAVARCVEGGVTHMCPASALQM 231

                        170
                 ....*....|....*....
gi 6912586   232 HTgKLCWFLDEAAARLLTV 250
Cdd:PTZ00285 232 HP-AAVLCLDEDATLELKV 249
PRK09762 PRK09762
galactosamine-6-phosphate isomerase; Provisional
 83-237 6.36e-10

galactosamine-6-phosphate isomerase; Provisional


Pssm-ID: 182064  Cd Length: 232  Bit Score: 57.53  E-value: 6.36e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912586    83 VPFDHAESTYGLYRTHLLSRLPIPESQVITINPElpveeaAEDYAKKLRQAFQGDSIPVFDLLILGVGPDGHTCSLFPDH 162
Cdd:PRK09762  72 LPLTMPGTCETFLQQHIVQPLGLREDQLISFRSE------EINETECERVTNLIARKGGLDLCVLGLGKNGHLGLNEPGE 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912586   163 PL--------LQEREKIVAPISDSPKPPPQRVTLTLPVLNAARTVIFVATGEGKAAVLKRILEDQEENPLPAALVQPHTG 234
Cdd:PRK09762 146 SLqpachisqLDARTQQHEMLKTAGRPVTRGITLGLKDILNAREVLLLVTGEGKQDATERFLTAKVSTAIPASFLWLHSN 225


                 ...
gi 6912586   235 KLC 237
Cdd:PRK09762 226 FIC 228
PRK02122 PRK02122
glucosamine-6-phosphate deaminase-like protein; Validated
 86-249 2.02e-09

glucosamine-6-phosphate deaminase-like protein; Validated


Pssm-ID: 235005 [Multi-domain]  Cd Length: 652  Bit Score: 57.35  E-value: 2.02e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912586    86 DHAESTYGLYRTHLLSRLPIPESQVITINPELPVEEAAE---DYAKKLRQAfqGDsipvFDLLILGVGPDGH-------- 154
Cdd:PRK02122 106 DSLQSYHRFMKENLFDHVDIPPENIHIPDGTIPKEEIDEycrDYEEKIEAA--GG----IDFQLLGIGRTGHigfnepgs 179

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912586   155 -----TCSLFPDHPllqEREKIVAPISDSPKPPPQRVTLTLPVLNAARTVIFVATGEGKAAVLKRILEDQEENPLPAALV 229
Cdd:PRK02122 180 grnsrTRLVTLDHI---TRRDAASDFFGEENVPRKAITMGVGTILKARRIVLLAWGEHKAPIIKRAVEGEISDEVPASYL 256

                        170       180
                 ....*....|....*....|
gi 6912586   230 QPHTgKLCWFLDEAAARLLT 249
Cdd:PRK02122 257 QEHP-NATFVLDLAAASELT 275
SugarP_isomerase cd00458
SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate ...
 79-173 2.67e-06

SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium, the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate. 6PGL converts 6-phosphoglucono-1,5-lactone to 6-phosphogluconate, the second step of the oxidative phase of the pentose phosphate pathway.


Pssm-ID: 238258  Cd Length: 169  Bit Score: 46.58  E-value: 2.67e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912586   79 DERLVPFDHAESTYGLYRTHLLSRLPIPESQVITINPELPVEEAAEDYAKKLRqafqgDSIPVFDLLILGVGPDGHTCSL 158
Cdd:cd00458  57 DERYVPLDSDQSNFRQAKLLAFEHDIIPASNVHYVDTSLPIEKACEKYEREIL-----DQVDAIDLAVDGAGYRAGTVIV 131

                        90
                ....*....|....*
gi 6912586  159 fpdhpLLQEREKIVA 173
Cdd:cd00458 132 -----LVDGRKKVDY 141
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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