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Conserved domains on  [gi|66932902|ref|NP_036367|]
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sterol regulatory element-binding protein cleavage-activating protein isoform 1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Sterol-sensing pfam12349
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins ...
 308-452 7.30e-57

Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.


:

Pssm-ID: 463544 [Multi-domain]  Cd Length: 153  Bit Score: 193.57  E-value: 7.30e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932902    308 MVKSKWGLALAAVVTVLSSLLMSVGLCTLFGLTPTLNGGEIFPYLVVVIGLENVLVLTKSVVSTPVDLEVKLRIAQGLSS 387
Cdd:pfam12349    1 MVKSKFGLGLAGVIIVLASVASSLGLCAYFGLPLTLIISEVIPFLVLAIGVDNIFLLVKAVVRTPRSLDVSERIAEALGE 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 66932902    388 ESWSIMKNMATELGIILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMLFFTTVLSIDIRRMELADL 452
Cdd:pfam12349   81 VGPSITLTSLTEILAFLLGALTDMPAVQEFCLFAAVAVLFDFLLQMTFFVAVLSLDIRRLESNRL 145
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1078-1235 2.22e-25

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 107.81  E-value: 2.22e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932902 1078 HQKPITALKAAA--GRLVTGSQDHTLRVFRLEDSCCLFTLQGHSGAITTV-YIDQTMVLASGGQDGAICLWDVLTGSRVS 1154
Cdd:cd00200    8 HTGGVTCVAFSPdgKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVaASADGTYLASGSSDKTIRLWDLETGECVR 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932902 1155 HVFAHRGDVTSLTCTTSC--VISSGLDDLISIWDRSTGIKFYSIQQDLGCGASLGVISDNLLVTGGQ--GCVSFWDLNYG 1230
Cdd:cd00200   88 TLTGHTSYVSSVAFSPDGriLSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSqdGTIKLWDLRTG 167


                 ....*
gi 66932902 1231 DLLQT 1235
Cdd:cd00200  168 KCVAT 172
WD40 COG2319
WD40 repeat [General function prediction only];
893-1235 1.64e-23

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.61  E-value: 1.64e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932902  893 PEPRHRAVCGRSRDSPGYDFSCLVQRVYQEEGLAAVCTPALRPPSPGPVLSQAPEDEGGSPEKGSPSLAWAPSAEGSIWS 972
Cdd:COG2319    4 ADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932902  973 LELQ--GNLIVVGRSSGRLEVWDAIEGVLCCSSEEVSSGITALVFLD--KRIVAARLNGSLDFFSLETHTALSPLqfRGT 1048
Cdd:COG2319   84 VAFSpdGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPdgKTLASGSADGTVRLWDLATGKLLRTL--TGH 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932902 1049 PGRGSSPA-SP----VYSSS--------DTVACHLTHTVPcAHQKPITALK-AAAGR-LVTGSQDHTLRVFRLEDSCCLF 1113
Cdd:COG2319  162 SGAVTSVAfSPdgklLASGSddgtvrlwDLATGKLLRTLT-GHTGAVRSVAfSPDGKlLASGSADGTVRLWDLATGKLLR 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932902 1114 TLQGHSGAITTVYI--DQTMvLASGGQDGAICLWDVLTGSRVSHVFAHRGDVTSLTCTT--SCVISSGLDDLISIWDRST 1189
Cdd:COG2319  241 TLTGHSGSVRSVAFspDGRL-LASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPdgKLLASGSDDGTVRLWDLAT 319

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 66932902 1190 GIKFYSIQQDLGCGASLGVISD-NLLVTGGQ-GCVSFWDLNYGDLLQT 1235
Cdd:COG2319  320 GKLLRTLTGHTGAVRSVAFSPDgKTLASGSDdGTVRLWDLATGELLRT 367
2A060601 super family cl36767
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ...
 11-466 5.56e-22

Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]


The actual alignment was detected with superfamily member TIGR00917:

Pssm-ID: 273337 [Multi-domain]  Cd Length: 1205  Bit Score: 103.45  E-value: 5.56e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932902     11 ISRAFYNHGLLCASYPIPIILFTGFCILACCYPLLKLPLPgtgpvefTTPVKDYSPPpvdsDRKQGEPTEQPEWYVGaPV 90
Cdd:TIGR00917  309 LARFFGKYGIWVARHPTLVICLSVSVVLLLCVGLIRFKVE-------TRPVKLWVAP----GSRAALEKQYFDTHFG-PF 376

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932902     91 AYVQQIFVKSSVFPWHK---NLLAVDVfrspLSRAFQLVEEIRNHVLRDSSGIRSLEELCLQVTDllPGlrklrnllpeh 167
Cdd:TIGR00917  377 YRIEQLIIATVQTSSHEkapEILTDDN----LKLLFDIQKKVSQLFANYEGELITLDSPCFKPNH--PY----------- 439

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932902    168 GCLLLSPGNFWQNDWERF---HADPDIIGTIHQH-EPKTLQTSATLKDllFGVP-------GKYSGVSLYTRKRMVsytI 236
Cdd:TIGR00917  440 NCFIYSTCKKLQNMYSKLkpeNYDDYGGVDYVKYcFEHFTSPESCLSA--FGGPvdpttvlGGFSGNNFSEASAFV---V 514

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932902    237 TLVFQHYHAK-------------FLGSLRARLmLLHPSPNCSLRAESLVHVHFKEEiGVAELIPLVTTYIILFAYIY--- 300
Cdd:TIGR00917  515 TFPVNNFVNKtnktekavawekaFIQLAKDEL-LPMVQATISFSAERSIEDELKRE-STADVITIAISYLVMFAYISltl 592

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932902    301 -FSTR-KIDMVKSKWGLALAAVVTVLSSLLMSVGLCTLFGLTPTLNGGEIFPYLVVVIGLENVLVLTKSV---------- 368
Cdd:TIGR00917  593 gDSPRlKSLYVTSKVLLGLSGILIVMLSVLGSVGVFSAVGLKSTLIIMEVIPFLVLAVGVDNIFILVFFYfyleyfyrqv 672

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932902    369 -VSTPVDLEVKLRIAQGLSSESWSIMKNMATELGIILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMLFFTTVLSIDIRRM 447
Cdd:TIGR00917  673 gVDNEQELTLERRLSRALMEVGPSITLASLSEILAFALGALIKMPAVRVFSMFAVLAVFLDFLLQITAFVALLVLDFKRT 752

                          490
                   ....*....|....*....
gi 66932902    448 EladlNKRLPPEACLPSAK 466
Cdd:TIGR00917  753 E----DKRVDCFPCIKTSK 767
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 771-802 1.98e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


:

Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 1.98e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 66932902     771 VLRGHLMDIECLA--SDGMLLVSCCLAGHVCVWD 802
Cdd:smart00320    7 TLKGHTGPVTSVAfsPDGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
Sterol-sensing pfam12349
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins ...
 308-452 7.30e-57

Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.


Pssm-ID: 463544 [Multi-domain]  Cd Length: 153  Bit Score: 193.57  E-value: 7.30e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932902    308 MVKSKWGLALAAVVTVLSSLLMSVGLCTLFGLTPTLNGGEIFPYLVVVIGLENVLVLTKSVVSTPVDLEVKLRIAQGLSS 387
Cdd:pfam12349    1 MVKSKFGLGLAGVIIVLASVASSLGLCAYFGLPLTLIISEVIPFLVLAIGVDNIFLLVKAVVRTPRSLDVSERIAEALGE 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 66932902    388 ESWSIMKNMATELGIILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMLFFTTVLSIDIRRMELADL 452
Cdd:pfam12349   81 VGPSITLTSLTEILAFLLGALTDMPAVQEFCLFAAVAVLFDFLLQMTFFVAVLSLDIRRLESNRL 145
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1078-1235 2.22e-25

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 107.81  E-value: 2.22e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932902 1078 HQKPITALKAAA--GRLVTGSQDHTLRVFRLEDSCCLFTLQGHSGAITTV-YIDQTMVLASGGQDGAICLWDVLTGSRVS 1154
Cdd:cd00200    8 HTGGVTCVAFSPdgKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVaASADGTYLASGSSDKTIRLWDLETGECVR 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932902 1155 HVFAHRGDVTSLTCTTSC--VISSGLDDLISIWDRSTGIKFYSIQQDLGCGASLGVISDNLLVTGGQ--GCVSFWDLNYG 1230
Cdd:cd00200   88 TLTGHTSYVSSVAFSPDGriLSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSqdGTIKLWDLRTG 167


                 ....*
gi 66932902 1231 DLLQT 1235
Cdd:cd00200  168 KCVAT 172
WD40 COG2319
WD40 repeat [General function prediction only];
893-1235 1.64e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.61  E-value: 1.64e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932902  893 PEPRHRAVCGRSRDSPGYDFSCLVQRVYQEEGLAAVCTPALRPPSPGPVLSQAPEDEGGSPEKGSPSLAWAPSAEGSIWS 972
Cdd:COG2319    4 ADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932902  973 LELQ--GNLIVVGRSSGRLEVWDAIEGVLCCSSEEVSSGITALVFLD--KRIVAARLNGSLDFFSLETHTALSPLqfRGT 1048
Cdd:COG2319   84 VAFSpdGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPdgKTLASGSADGTVRLWDLATGKLLRTL--TGH 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932902 1049 PGRGSSPA-SP----VYSSS--------DTVACHLTHTVPcAHQKPITALK-AAAGR-LVTGSQDHTLRVFRLEDSCCLF 1113
Cdd:COG2319  162 SGAVTSVAfSPdgklLASGSddgtvrlwDLATGKLLRTLT-GHTGAVRSVAfSPDGKlLASGSADGTVRLWDLATGKLLR 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932902 1114 TLQGHSGAITTVYI--DQTMvLASGGQDGAICLWDVLTGSRVSHVFAHRGDVTSLTCTT--SCVISSGLDDLISIWDRST 1189
Cdd:COG2319  241 TLTGHSGSVRSVAFspDGRL-LASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPdgKLLASGSDDGTVRLWDLAT 319

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 66932902 1190 GIKFYSIQQDLGCGASLGVISD-NLLVTGGQ-GCVSFWDLNYGDLLQT 1235
Cdd:COG2319  320 GKLLRTLTGHTGAVRSVAFSPDgKTLASGSDdGTVRLWDLATGELLRT 367
2A060601 TIGR00917
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ...
 11-466 5.56e-22

Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]


Pssm-ID: 273337 [Multi-domain]  Cd Length: 1205  Bit Score: 103.45  E-value: 5.56e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932902     11 ISRAFYNHGLLCASYPIPIILFTGFCILACCYPLLKLPLPgtgpvefTTPVKDYSPPpvdsDRKQGEPTEQPEWYVGaPV 90
Cdd:TIGR00917  309 LARFFGKYGIWVARHPTLVICLSVSVVLLLCVGLIRFKVE-------TRPVKLWVAP----GSRAALEKQYFDTHFG-PF 376

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932902     91 AYVQQIFVKSSVFPWHK---NLLAVDVfrspLSRAFQLVEEIRNHVLRDSSGIRSLEELCLQVTDllPGlrklrnllpeh 167
Cdd:TIGR00917  377 YRIEQLIIATVQTSSHEkapEILTDDN----LKLLFDIQKKVSQLFANYEGELITLDSPCFKPNH--PY----------- 439

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932902    168 GCLLLSPGNFWQNDWERF---HADPDIIGTIHQH-EPKTLQTSATLKDllFGVP-------GKYSGVSLYTRKRMVsytI 236
Cdd:TIGR00917  440 NCFIYSTCKKLQNMYSKLkpeNYDDYGGVDYVKYcFEHFTSPESCLSA--FGGPvdpttvlGGFSGNNFSEASAFV---V 514

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932902    237 TLVFQHYHAK-------------FLGSLRARLmLLHPSPNCSLRAESLVHVHFKEEiGVAELIPLVTTYIILFAYIY--- 300
Cdd:TIGR00917  515 TFPVNNFVNKtnktekavawekaFIQLAKDEL-LPMVQATISFSAERSIEDELKRE-STADVITIAISYLVMFAYISltl 592

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932902    301 -FSTR-KIDMVKSKWGLALAAVVTVLSSLLMSVGLCTLFGLTPTLNGGEIFPYLVVVIGLENVLVLTKSV---------- 368
Cdd:TIGR00917  593 gDSPRlKSLYVTSKVLLGLSGILIVMLSVLGSVGVFSAVGLKSTLIIMEVIPFLVLAVGVDNIFILVFFYfyleyfyrqv 672

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932902    369 -VSTPVDLEVKLRIAQGLSSESWSIMKNMATELGIILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMLFFTTVLSIDIRRM 447
Cdd:TIGR00917  673 gVDNEQELTLERRLSRALMEVGPSITLASLSEILAFALGALIKMPAVRVFSMFAVLAVFLDFLLQITAFVALLVLDFKRT 752

                          490
                   ....*....|....*....
gi 66932902    448 EladlNKRLPPEACLPSAK 466
Cdd:TIGR00917  753 E----DKRVDCFPCIKTSK 767
WD40 COG2319
WD40 repeat [General function prediction only];
972-1235 1.31e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 92.67  E-value: 1.31e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932902  972 SLELQGNLIVVGRSSGRLEVWDAIEGVLCCSSEEVSSGITALVFLDKRIVAARLNGSLDFFSLETHTALSPLQFRGTPGR 1051
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932902 1052 G-----SSPASPVYSSSD-------TVACHLTHTVPCAHQKPITALKAAA--GRLVTGSQDHTLRVFRLEDSCCLFTLQG 1117
Cdd:COG2319   81 VlsvafSPDGRLLASASAdgtvrlwDLATGLLLRTLTGHTGAVRSVAFSPdgKTLASGSADGTVRLWDLATGKLLRTLTG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932902 1118 HSGAITTVYI--DQTMvLASGGQDGAICLWDVLTGSRVSHVFAHRGDVTSLTCTT--SCVISSGLDDLISIWDRSTGIKF 1193
Cdd:COG2319  161 HSGAVTSVAFspDGKL-LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPdgKLLASGSADGTVRLWDLATGKLL 239

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 66932902 1194 YSIQQDLGCGASLGVISDN-LLVTGGQ-GCVSFWDLNYGDLLQT 1235
Cdd:COG2319  240 RTLTGHSGSVRSVAFSPDGrLLASGSAdGTVRLWDLATGELLRT 283
2A060605 TIGR00920
3-hydroxy-3-methylglutaryl-coenzyme A reductase; [Transport and binding proteins, ...
 276-442 8.26e-14

3-hydroxy-3-methylglutaryl-coenzyme A reductase; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273339 [Multi-domain]  Cd Length: 886  Bit Score: 76.43  E-value: 8.26e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932902    276 FKEEIGVAELIPLVTTYIILFAYIYFSTRKIDMVKSKWGLALAAVVTVLSSLLMSVGLCTLFGLTPT-LNggEIFPYLVV 354
Cdd:TIGR00920   53 FEEEYLSSDVIVMTITRCIAVLYIYYQFCNLRQLGSKYILGIAGLFTIFSSFVFSTAVIHFLGSELTgLN--EALPFFLL 130

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932902    355 VIGLENVLVLTKSVVSTPVDLEVKLRIAQGLSSESWSIMKNMATELGIILIGYFTLVPAIQEFCLFAVVGLVSDFFLQML 434
Cdd:TIGR00920  131 LIDLSKASALAKFALSSNSQDEVRDNIARGMAILGPTITLDTVVETLVIGVGTMSGVRRLEVLCCFGCMSVLANYFVFMT 210


                   ....*...
gi 66932902    435 FFTTVLSI 442
Cdd:TIGR00920  211 FFPACLSL 218
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 1108-1146 1.57e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 1.57e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 66932902    1108 DSCCLFTLQGHSGAITTVYIDQT-MVLASGGQDGAICLWD 1146
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDgKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
1111-1146 7.13e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 7.13e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 66932902   1111 CLFTLQGHSGAITTVYIDQT-MVLASGGQDGAICLWD 1146
Cdd:pfam00400    3 LLKTLEGHTGSVTSLAFSPDgKLLASGSDDGTVKVWD 39
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
285-442 9.57e-04

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 43.70  E-value: 9.57e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932902  285 LIPLVTTYIILFAYIYFstrkidmvKSKWGLALAaVVTVLSSLLMSVGLCTLFG--LTPTLNggeIFPYLVVVIGLENVL 362
Cdd:COG1033  223 FFPLALLLILLLLFLFF--------RSLRGVLLP-LLVVLLAVIWTLGLMGLLGipLSPLTI---LVPPLLLAIGIDYGI 290

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932902  363 -VLTKsvvstpvdleVKLRIAQGLSSESwsIMKNMATELGI-IL-------IGYFTL----VPAIQEFCLFAVVGLVSDF 429
Cdd:COG1033  291 hLLNR----------YREERRKGLDKRE--ALREALRKLGPpVLltslttaIGFLSLlfsdIPPIRDFGIVAAIGVLLAF 358

                        170
                 ....*....|...
gi 66932902  430 FLQMLFFTTVLSI 442
Cdd:COG1033  359 LTSLTLLPALLSL 371
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 771-802 1.98e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 1.98e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 66932902     771 VLRGHLMDIECLA--SDGMLLVSCCLAGHVCVWD 802
Cdd:smart00320    7 TLKGHTGPVTSVAfsPDGKYLASGSDDGTIKLWD 40
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 771-813 3.62e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 40.78  E-value: 3.62e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 66932902  771 VLRGHLMDIECLA--SDGMLLVSCCLAGHVCVWDAQTGDCLTRIP 813
Cdd:cd00200  214 TLRGHENGVNSVAfsPDGYLLASGSEDGTIRVWDLRTGECVQTLS 258
 
Name Accession Description Interval E-value
Sterol-sensing pfam12349
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins ...
 308-452 7.30e-57

Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.


Pssm-ID: 463544 [Multi-domain]  Cd Length: 153  Bit Score: 193.57  E-value: 7.30e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932902    308 MVKSKWGLALAAVVTVLSSLLMSVGLCTLFGLTPTLNGGEIFPYLVVVIGLENVLVLTKSVVSTPVDLEVKLRIAQGLSS 387
Cdd:pfam12349    1 MVKSKFGLGLAGVIIVLASVASSLGLCAYFGLPLTLIISEVIPFLVLAIGVDNIFLLVKAVVRTPRSLDVSERIAEALGE 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 66932902    388 ESWSIMKNMATELGIILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMLFFTTVLSIDIRRMELADL 452
Cdd:pfam12349   81 VGPSITLTSLTEILAFLLGALTDMPAVQEFCLFAAVAVLFDFLLQMTFFVAVLSLDIRRLESNRL 145
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1078-1235 2.22e-25

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 107.81  E-value: 2.22e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932902 1078 HQKPITALKAAA--GRLVTGSQDHTLRVFRLEDSCCLFTLQGHSGAITTV-YIDQTMVLASGGQDGAICLWDVLTGSRVS 1154
Cdd:cd00200    8 HTGGVTCVAFSPdgKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVaASADGTYLASGSSDKTIRLWDLETGECVR 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932902 1155 HVFAHRGDVTSLTCTTSC--VISSGLDDLISIWDRSTGIKFYSIQQDLGCGASLGVISDNLLVTGGQ--GCVSFWDLNYG 1230
Cdd:cd00200   88 TLTGHTSYVSSVAFSPDGriLSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSqdGTIKLWDLRTG 167


                 ....*
gi 66932902 1231 DLLQT 1235
Cdd:cd00200  168 KCVAT 172
WD40 COG2319
WD40 repeat [General function prediction only];
893-1235 1.64e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.61  E-value: 1.64e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932902  893 PEPRHRAVCGRSRDSPGYDFSCLVQRVYQEEGLAAVCTPALRPPSPGPVLSQAPEDEGGSPEKGSPSLAWAPSAEGSIWS 972
Cdd:COG2319    4 ADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932902  973 LELQ--GNLIVVGRSSGRLEVWDAIEGVLCCSSEEVSSGITALVFLD--KRIVAARLNGSLDFFSLETHTALSPLqfRGT 1048
Cdd:COG2319   84 VAFSpdGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPdgKTLASGSADGTVRLWDLATGKLLRTL--TGH 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932902 1049 PGRGSSPA-SP----VYSSS--------DTVACHLTHTVPcAHQKPITALK-AAAGR-LVTGSQDHTLRVFRLEDSCCLF 1113
Cdd:COG2319  162 SGAVTSVAfSPdgklLASGSddgtvrlwDLATGKLLRTLT-GHTGAVRSVAfSPDGKlLASGSADGTVRLWDLATGKLLR 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932902 1114 TLQGHSGAITTVYI--DQTMvLASGGQDGAICLWDVLTGSRVSHVFAHRGDVTSLTCTT--SCVISSGLDDLISIWDRST 1189
Cdd:COG2319  241 TLTGHSGSVRSVAFspDGRL-LASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPdgKLLASGSDDGTVRLWDLAT 319

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 66932902 1190 GIKFYSIQQDLGCGASLGVISD-NLLVTGGQ-GCVSFWDLNYGDLLQT 1235
Cdd:COG2319  320 GKLLRTLTGHTGAVRSVAFSPDgKTLASGSDdGTVRLWDLATGELLRT 367
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 967-1235 3.64e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 101.26  E-value: 3.64e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932902  967 EGSIWSLEL--QGNLIVVGRSSGRLEVWDAIEGVLCCSSEEVSSGITALVFL--DKRIVAARLNGSLDFFSLEThtalsp 1042
Cdd:cd00200    9 TGGVTCVAFspDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASadGTYLASGSSDKTIRLWDLET------ 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932902 1043 lqfrgtpgrgsspaspvysssdtvaCHLTHTVPCaHQKPITALKAAAGR--LVTGSQDHTLRVFRLEDSCCLFTLQGHSG 1120
Cdd:cd00200   83 -------------------------GECVRTLTG-HTSYVSSVAFSPDGriLSSSSRDKTIKVWDVETGKCLTTLRGHTD 136

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932902 1121 AITTVYIDQT-MVLASGGQDGAICLWDVLTGSRVsHVF-AHRGDVTSLTC--TTSCVISSGLDDLISIWDRSTGIKFYSI 1196
Cdd:cd00200  137 WVNSVAFSPDgTFVASSSQDGTIKLWDLRTGKCV-ATLtGHTGEVNSVAFspDGEKLLSSSSDGTIKLWDLSTGKCLGTL 215

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 66932902 1197 QQDLGCGASLGVISDNLLVTGG--QGCVSFWDLNYGDLLQT 1235
Cdd:cd00200  216 RGHENGVNSVAFSPDGYLLASGseDGTIRVWDLRTGECVQT 256
2A060601 TIGR00917
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ...
 11-466 5.56e-22

Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]


Pssm-ID: 273337 [Multi-domain]  Cd Length: 1205  Bit Score: 103.45  E-value: 5.56e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932902     11 ISRAFYNHGLLCASYPIPIILFTGFCILACCYPLLKLPLPgtgpvefTTPVKDYSPPpvdsDRKQGEPTEQPEWYVGaPV 90
Cdd:TIGR00917  309 LARFFGKYGIWVARHPTLVICLSVSVVLLLCVGLIRFKVE-------TRPVKLWVAP----GSRAALEKQYFDTHFG-PF 376

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932902     91 AYVQQIFVKSSVFPWHK---NLLAVDVfrspLSRAFQLVEEIRNHVLRDSSGIRSLEELCLQVTDllPGlrklrnllpeh 167
Cdd:TIGR00917  377 YRIEQLIIATVQTSSHEkapEILTDDN----LKLLFDIQKKVSQLFANYEGELITLDSPCFKPNH--PY----------- 439

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932902    168 GCLLLSPGNFWQNDWERF---HADPDIIGTIHQH-EPKTLQTSATLKDllFGVP-------GKYSGVSLYTRKRMVsytI 236
Cdd:TIGR00917  440 NCFIYSTCKKLQNMYSKLkpeNYDDYGGVDYVKYcFEHFTSPESCLSA--FGGPvdpttvlGGFSGNNFSEASAFV---V 514

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932902    237 TLVFQHYHAK-------------FLGSLRARLmLLHPSPNCSLRAESLVHVHFKEEiGVAELIPLVTTYIILFAYIY--- 300
Cdd:TIGR00917  515 TFPVNNFVNKtnktekavawekaFIQLAKDEL-LPMVQATISFSAERSIEDELKRE-STADVITIAISYLVMFAYISltl 592

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932902    301 -FSTR-KIDMVKSKWGLALAAVVTVLSSLLMSVGLCTLFGLTPTLNGGEIFPYLVVVIGLENVLVLTKSV---------- 368
Cdd:TIGR00917  593 gDSPRlKSLYVTSKVLLGLSGILIVMLSVLGSVGVFSAVGLKSTLIIMEVIPFLVLAVGVDNIFILVFFYfyleyfyrqv 672

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932902    369 -VSTPVDLEVKLRIAQGLSSESWSIMKNMATELGIILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMLFFTTVLSIDIRRM 447
Cdd:TIGR00917  673 gVDNEQELTLERRLSRALMEVGPSITLASLSEILAFALGALIKMPAVRVFSMFAVLAVFLDFLLQITAFVALLVLDFKRT 752

                          490
                   ....*....|....*....
gi 66932902    448 EladlNKRLPPEACLPSAK 466
Cdd:TIGR00917  753 E----DKRVDCFPCIKTSK 767
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 976-1186 1.89e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 93.17  E-value: 1.89e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932902  976 QGNLIVVGRSSGRLEVWDAIEGVLCCSSEEVSSGITALVFLDKR--IVAARLNGSLDFFSLETHTALSPLQFRGTPGRG- 1052
Cdd:cd00200   62 DGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGriLSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSv 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932902 1053 -SSPASPVYSSS---------DTVACHLTHTVPcAHQKPITALKAAA--GRLVTGSQDHTLRVFRLEDSCCLFTLQGHSG 1120
Cdd:cd00200  142 aFSPDGTFVASSsqdgtiklwDLRTGKCVATLT-GHTGEVNSVAFSPdgEKLLSSSSDGTIKLWDLSTGKCLGTLRGHEN 220

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 66932902 1121 AITTV-YIDQTMVLASGGQDGAICLWDVLTGSRVSHVFAHRGDVTSLTC--TTSCVISSGLDDLISIWD 1186
Cdd:cd00200  221 GVNSVaFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWspDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
972-1235 1.31e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 92.67  E-value: 1.31e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932902  972 SLELQGNLIVVGRSSGRLEVWDAIEGVLCCSSEEVSSGITALVFLDKRIVAARLNGSLDFFSLETHTALSPLQFRGTPGR 1051
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932902 1052 G-----SSPASPVYSSSD-------TVACHLTHTVPCAHQKPITALKAAA--GRLVTGSQDHTLRVFRLEDSCCLFTLQG 1117
Cdd:COG2319   81 VlsvafSPDGRLLASASAdgtvrlwDLATGLLLRTLTGHTGAVRSVAFSPdgKTLASGSADGTVRLWDLATGKLLRTLTG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932902 1118 HSGAITTVYI--DQTMvLASGGQDGAICLWDVLTGSRVSHVFAHRGDVTSLTCTT--SCVISSGLDDLISIWDRSTGIKF 1193
Cdd:COG2319  161 HSGAVTSVAFspDGKL-LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPdgKLLASGSADGTVRLWDLATGKLL 239

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 66932902 1194 YSIQQDLGCGASLGVISDN-LLVTGGQ-GCVSFWDLNYGDLLQT 1235
Cdd:COG2319  240 RTLTGHSGSVRSVAFSPDGrLLASGSAdGTVRLWDLATGELLRT 283
WD40 COG2319
WD40 repeat [General function prediction only];
967-1189 8.08e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 90.36  E-value: 8.08e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932902  967 EGSIWSLEL--QGNLIVVGRSSGRLEVWDAIEGVLCCSSEEVSSGITALVFL--DKRIVAARLNGSLDFFSLETHTALSP 1042
Cdd:COG2319  162 SGAVTSVAFspDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSpdGKLLASGSADGTVRLWDLATGKLLRT 241

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932902 1043 LqfRGTPGRGSSPA-SP-----VYSSSDTVAC-------HLTHTVPcAHQKPITALKAAA-GR-LVTGSQDHTLRVFRLE 1107
Cdd:COG2319  242 L--TGHSGSVRSVAfSPdgrllASGSADGTVRlwdlatgELLRTLT-GHSGGVNSVAFSPdGKlLASGSDDGTVRLWDLA 318

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932902 1108 DSCCLFTLQGHSGAITTVYI---DQTmvLASGGQDGAICLWDVLTGSRVSHVFAHRGDVTSLTCTT--SCVISSGLDDLI 1182
Cdd:COG2319  319 TGKLLRTLTGHTGAVRSVAFspdGKT--LASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPdgRTLASGSADGTV 396


                 ....*..
gi 66932902 1183 SIWDRST 1189
Cdd:COG2319  397 RLWDLAT 403
Patched pfam02460
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ...
 284-533 1.27e-17

Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.


Pssm-ID: 308203 [Multi-domain]  Cd Length: 793  Bit Score: 88.57  E-value: 1.27e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932902    284 ELIP-LVTTYIILFAY-----IYFSTRKIDMVKSKWGLALAAVVTVLSSLLMSVGLCTLFGLtPTLNGGEIFPYLVVVIG 357
Cdd:pfam02460  214 TLTPfFVIGFFLLLTFsiivsVTLSSYTIDWVRSKPILAALGLLSPVMAIVSSFGLLFWMGF-PFNSIVCVTPFLVLAIG 292

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932902    358 LENVLVLTKSVVSTPVDLEVKLRIAQGLSSESWSIMKNMATELGIILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMLFFT 437
Cdd:pfam02460  293 VDDMFLMVAAWQRTTATLSVKKRMGEALSEAGVSITITSLTDVLSFGIGTYTPTPAIQLFCAYTAVAIFFDFIYQITFFA 372

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932902    438 TVLSIdirrMELADLNKRLPPEACLPSakpvgQPTRYERQLAVRPSTPHTITLQPSSFRNLRLPkrlrvvyFLARTRLaq 517
Cdd:pfam02460  373 AIMAI----CAKPEAEGRHCLFVWATS-----SPQRIDSEGSEPDKSHNIEQLKSRFFLDIYCP-------FLLNPSV-- 434

                          250
                   ....*....|....*..
gi 66932902    518 RLIMAGT-VVWIGILVY 533
Cdd:pfam02460  435 RVCMLVLfVVYIAIAIY 451
WD40 COG2319
WD40 repeat [General function prediction only];
959-1147 5.53e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 81.88  E-value: 5.53e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932902  959 SLAWAPsaegsiwslelQGNLIVVGRSSGRLEVWDAIEGVLCCSSEEVSSGITALVFL--DKRIVAARLNGSLDFFSLET 1036
Cdd:COG2319  209 SVAFSP-----------DGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSpdGRLLASGSADGTVRLWDLAT 277

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932902 1037 HTALSPLqfRGTPGRGSSPA-SP-----VYSSSDTVAC-------HLTHTVPcAHQKPITALKAAA--GRLVTGSQDHTL 1101
Cdd:COG2319  278 GELLRTL--TGHSGGVNSVAfSPdgkllASGSDDGTVRlwdlatgKLLRTLT-GHTGAVRSVAFSPdgKTLASGSDDGTV 354

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 66932902 1102 RVFRLEDSCCLFTLQGHSGAITTVYI--DQTMvLASGGQDGAICLWDV 1147
Cdd:COG2319  355 RLWDLATGELLRTLTGHTGAVTSVAFspDGRT-LASGSADGTVRLWDL 401
2A060605 TIGR00920
3-hydroxy-3-methylglutaryl-coenzyme A reductase; [Transport and binding proteins, ...
 276-442 8.26e-14

3-hydroxy-3-methylglutaryl-coenzyme A reductase; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273339 [Multi-domain]  Cd Length: 886  Bit Score: 76.43  E-value: 8.26e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932902    276 FKEEIGVAELIPLVTTYIILFAYIYFSTRKIDMVKSKWGLALAAVVTVLSSLLMSVGLCTLFGLTPT-LNggEIFPYLVV 354
Cdd:TIGR00920   53 FEEEYLSSDVIVMTITRCIAVLYIYYQFCNLRQLGSKYILGIAGLFTIFSSFVFSTAVIHFLGSELTgLN--EALPFFLL 130

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932902    355 VIGLENVLVLTKSVVSTPVDLEVKLRIAQGLSSESWSIMKNMATELGIILIGYFTLVPAIQEFCLFAVVGLVSDFFLQML 434
Cdd:TIGR00920  131 LIDLSKASALAKFALSSNSQDEVRDNIARGMAILGPTITLDTVVETLVIGVGTMSGVRRLEVLCCFGCMSVLANYFVFMT 210


                   ....*...
gi 66932902    435 FFTTVLSI 442
Cdd:TIGR00920  211 FFPACLSL 218
2A060602 TIGR00918
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
286-491 1.27e-13

The Eukaryotic (Putative) Sterol Transporter (EST) Family;


Pssm-ID: 273338 [Multi-domain]  Cd Length: 1145  Bit Score: 76.07  E-value: 1.27e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932902    286 IPLVTTYIILFAYIYFSTRKIDMVKSKWGLALAAVVTVLSSLLMSVGLCTLFGLTPTLNGGEIFPYLVVVIGLENVLVLT 365
Cdd:TIGR00918  400 IRIVSGYLLMLAYACLTMLRWDCAKSQGSVGLAGVLLVALSVAAGLGLCALLGISFNAATTQVLPFLALGVGVDDVFLLA 479

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932902    366 KSVVSTPVDLEVKLRIAQGLSSESWSIMKNMATELGIILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMLFFTTVLSIDIR 445
Cdd:TIGR00918  480 HAFSETGQNIPFEERTGECLKRTGASVVLTSISNVTAFFMAALIPIPALRAFSLQAAIVVVFNFAAVLLVFPAILSLDLR 559

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 66932902    446 RMEladlNKRLPPEACL--PSAKPVGQ--PTRYERQLAVRPSTPH-TITLQ 491
Cdd:TIGR00918  560 RRE----DRRLDIFCCFfsPCSARVIQiePQAYADGSAPPVYSSHmQSTVQ 606
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1111-1235 5.62e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 70.83  E-value: 5.62e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932902 1111 CLFTLQGHSGAITTV-YIDQTMVLASGGQDGAICLWDVLTGSRVSHVFAHRGDVTSLTCT--TSCVISSGLDDLISIWDR 1187
Cdd:cd00200    1 LRRTLKGHTGGVTCVaFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASadGTYLASGSSDKTIRLWDL 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 66932902 1188 STGIKFYSIQQDLGCGASLGVISDNLLVTGG--QGCVSFWDLNYGDLLQT 1235
Cdd:cd00200   81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSsrDKTIKVWDVETGKCLTT 130
WD40 COG2319
WD40 repeat [General function prediction only];
1069-1236 1.48e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 68.01  E-value: 1.48e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932902 1069 HLTHTVPCAHQKPITALKAAAGRLVTGSQDHTLRVFRLEDSCCLFTLQGHSGAITTV-YIDQTMVLASGGQDGAICLWDV 1147
Cdd:COG2319   28 LLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVaFSPDGRLLASASADGTVRLWDL 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932902 1148 LTGSRVSHVFAHRGDVTSLTCT--TSCVISSGLDDLISIWDRSTGIKFYSIQQDLGCGASLGVISD-NLLVTGGQ-GCVS 1223
Cdd:COG2319  108 ATGLLLRTLTGHTGAVRSVAFSpdGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDgKLLASGSDdGTVR 187

                        170
                 ....*....|...
gi 66932902 1224 FWDLNYGDLLQTV 1236
Cdd:COG2319  188 LWDLATGKLLRTL 200
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 1108-1146 1.57e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 1.57e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 66932902    1108 DSCCLFTLQGHSGAITTVYIDQT-MVLASGGQDGAICLWD 1146
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDgKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
1111-1146 7.13e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 7.13e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 66932902   1111 CLFTLQGHSGAITTVYIDQT-MVLASGGQDGAICLWD 1146
Cdd:pfam00400    3 LLKTLEGHTGSVTSLAFSPDgKLLASGSDDGTVKVWD 39
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
285-442 9.57e-04

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 43.70  E-value: 9.57e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932902  285 LIPLVTTYIILFAYIYFstrkidmvKSKWGLALAaVVTVLSSLLMSVGLCTLFG--LTPTLNggeIFPYLVVVIGLENVL 362
Cdd:COG1033  223 FFPLALLLILLLLFLFF--------RSLRGVLLP-LLVVLLAVIWTLGLMGLLGipLSPLTI---LVPPLLLAIGIDYGI 290

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932902  363 -VLTKsvvstpvdleVKLRIAQGLSSESwsIMKNMATELGI-IL-------IGYFTL----VPAIQEFCLFAVVGLVSDF 429
Cdd:COG1033  291 hLLNR----------YREERRKGLDKRE--ALREALRKLGPpVLltslttaIGFLSLlfsdIPPIRDFGIVAAIGVLLAF 358

                        170
                 ....*....|...
gi 66932902  430 FLQMLFFTTVLSI 442
Cdd:COG1033  359 LTSLTLLPALLSL 371
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 771-802 1.98e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 1.98e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 66932902     771 VLRGHLMDIECLA--SDGMLLVSCCLAGHVCVWD 802
Cdd:smart00320    7 TLKGHTGPVTSVAfsPDGKYLASGSDDGTIKLWD 40
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 771-813 3.62e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 40.78  E-value: 3.62e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 66932902  771 VLRGHLMDIECLA--SDGMLLVSCCLAGHVCVWDAQTGDCLTRIP 813
Cdd:cd00200  214 TLRGHENGVNSVAfsPDGYLLASGSEDGTIRVWDLRTGECVQTLS 258
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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