|
Name |
Accession |
Description |
Interval |
E-value |
| PRK09259 |
PRK09259 |
putative oxalyl-CoA decarboxylase; Validated |
7-563 |
0e+00 |
|
putative oxalyl-CoA decarboxylase; Validated
Pssm-ID: 236433 [Multi-domain] Cd Length: 569 Bit Score: 573.47 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 7 AERSEEQVSGAKVIAQALKTQDVEYIFGIVGIPVTEIAIAAQQLGIKYIGMRNEQAACYAASAIGYLTSRPGVCLVVSGP 86
Cdd:PRK09259 3 MSDQLQLTDGFHLVIDALKLNGIDTIYGVVGIPITDLARLAQAEGIRYIGFRHEQSAGNAAAAAGFLTQKPGVCLTVSAP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 87 GLIHALGGMANANMNCWPLLVIGGSSERN----QEtmGAFQEFPQVEACRLYTKFSARPSSIEAIPFVIEKAVRSSIYGR 162
Cdd:PRK09259 83 GFLNGLTALANATTNCFPMIMISGSSEREivdlQQ--GDYEELDQLNAAKPFCKAAFRVNRAEDIGIGVARAIRTAVSGR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 163 PGACYVDIPADFVNLQVNVN-SIKYMERCMSP-PISMAETSAVCTAASVIRNAKQPLLIIGKGAAYAHAEESIKKLVEQY 240
Cdd:PRK09259 161 PGGVYLDLPAKVLAQTMDADeALTSLVKVVDPaPAQLPAPEAVDRALDLLKKAKRPLIILGKGAAYAQADEQIREFVEKT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 241 KLPFLPTPMGKGVVPDNHPYCVGAARSRALQFADVIVLFGARLNWILHFGLPPRYQPDVKFIQVDICAEELGNNVKPAVT 320
Cdd:PRK09259 241 GIPFLPMSMAKGLLPDTHPQSAAAARSLALANADVVLLVGARLNWLLSHGKGKTWGADKKFIQIDIEPQEIDSNRPIAAP 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 321 LLGNIHAVTKQLLEELDKTPWQYPPEskWWKTLREKMKSNEAASKELASKKSLPMNYYTVFYHVQEQLP--RDCFVVSEG 398
Cdd:PRK09259 321 VVGDIGSVMQALLAGLKQNTFKAPAE--WLDALAERKEKNAAKMAEKLSTDTQPMNFYNALGAIRDVLKenPDIYLVNEG 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 399 ANTMDIGRTVLQNYLPRHRLDAGTFGTMGVGLGFAIAAAVVAkdrspGQWIICVEGDSAFGFSGMEVETICRYNLPIILL 478
Cdd:PRK09259 399 ANTLDLARNIIDMYKPRHRLDCGTWGVMGIGMGYAIAAAVET-----GKPVVAIEGDSAFGFSGMEVETICRYNLPVTVV 473
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 479 VVNNNGIYQGFDTDTwkemlkfqDATAVVPPMCLLPNSHYEQVMTAFGGKGYFVQTPEELQKSLRQSLAdTTKPSLINIM 558
Cdd:PRK09259 474 IFNNGGIYRGDDVNL--------SGAGDPSPTVLVHHARYDKMMEAFGGVGYNVTTPDELRHALTEAIA-SGKPTLINVV 544
|
....*
gi 93004078 559 IEPQA 563
Cdd:PRK09259 545 IDPAA 549
|
|
| oxalate_oxc |
TIGR03254 |
oxalyl-CoA decarboxylase; In a number of bacteria, including Oxalobacter formigenes from the ... |
12-563 |
0e+00 |
|
oxalyl-CoA decarboxylase; In a number of bacteria, including Oxalobacter formigenes from the human gut, a two-gene operon of oxc (oxalyl-CoA decarboxylase) and frc (formyl-CoA transferase) encodes a system for degrading and therefore detoxifying oxalate. Members of this family are the thiamine pyrophosphate (TPP)-containing enzyme oxalyl-CoA decarboxylase. [Cellular processes, Detoxification]
Pssm-ID: 132298 [Multi-domain] Cd Length: 554 Bit Score: 534.02 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 12 EQVSGAKVIAQALKTQDVEYIFGIVGIPVTEIAIAAQQLGIKYIGMRNEQAACYAASAIGYLTSRPGVCLVVSGPGLIHA 91
Cdd:TIGR03254 1 ALTDGFHLVIDALKLNGINTIYGVVGIPVTDLARLAQAKGMRYIGFRHEQSAGYAAAAAGFLTQKPGVCLTVSAPGFLNG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 92 LGGMANANMNCWPLLVIGGSSERNQETM--GAFQEFPQVEACRLYTKFSARPSSIEAIPFVIEKAVRSSIYGRPGACYVD 169
Cdd:TIGR03254 81 LTALANATTNCFPMIMISGSSERHIVDLqqGDYEEMDQLAAAKPFAKAAYRVLRAEDIGIGIARAIRTAVSGRPGGVYLD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 170 IPADFVNLQVNVN-SIKYMERCMSP-PISMAETSAVCTAASVIRNAKQPLLIIGKGAAYAHAEESIKKLVEQYKLPFLPT 247
Cdd:TIGR03254 161 LPAAVLGQTMEAEkAKKTLVKVVDPaPKQLPSPDSVDRAVELLKDAKRPLILLGKGAAYAQADEEIREFVEKTGIPFLPM 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 248 PMGKGVVPDNHPYCVGAARSRALQFADVIVLFGARLNWILHFGLPPRYQPDVKFIQVDICAEELGNNVKPAVTLLGNIHA 327
Cdd:TIGR03254 241 SMAKGLLPDTHPQSAAAARSFALAEADVVMLVGARLNWLLSHGKGKLWGEDAKFIQVDIEPTEMDSNRPIAAPVVGDIGS 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 328 VTKQLLEELdKTPWQYPPeSKWWKTLREKMKSNEAASKELASKKSLPMNYYTVFYHVQEQLPR--DCFVVSEGANTMDIG 405
Cdd:TIGR03254 321 VVQALLSAA-KNGGVKPP-ADWRNAIKTKSEKNVAKMAERLSASESPMNYHGALEAIRDVLKDnpDIYLVNEGANTLDLA 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 406 RTVLQNYLPRHRLDAGTFGTMGVGLGFAIAAAVvakdrSPGQWIICVEGDSAFGFSGMEVETICRYNLPIILLVVNNNGI 485
Cdd:TIGR03254 399 RNVIDMYKPRHRLDVGTWGVMGIGMGYAIAAAV-----ETGKPVVALEGDSAFGFSGMEVETICRYNLPVCVVIFNNGGI 473
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 93004078 486 YQGFDTDTwkemlkfqdATAVVPPMCLLPNSHYEQVMTAFGGKGYFVQTPEELQKSLRQSLAdTTKPSLINIMIEPQA 563
Cdd:TIGR03254 474 YRGDDVNV---------VGADPAPTVLVHGARYDKMMKAFGGVGYNVTTPDELKAALNEALA-SGKPTLINAVIDPSA 541
|
|
| IlvB |
COG0028 |
Acetolactate synthase large subunit or other thiamine pyrophosphate-requiring enzyme [Amino ... |
12-563 |
4.34e-148 |
|
Acetolactate synthase large subunit or other thiamine pyrophosphate-requiring enzyme [Amino acid transport and metabolism, Coenzyme transport and metabolism]; Acetolactate synthase large subunit or other thiamine pyrophosphate-requiring enzyme is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis
Pssm-ID: 439799 [Multi-domain] Cd Length: 548 Bit Score: 437.67 E-value: 4.34e-148
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 12 EQVSGAKVIAQALKTQDVEYIFGIVGIPVTEI--AIAAQQlGIKYIGMRNEQAACYAASAIGYLTSRPGVCLVVSGPGLI 89
Cdd:COG0028 1 MKMTGADALVEALEAEGVETVFGVPGGAILPLydALRRQS-GIRHILVRHEQGAAFMADGYARATGKPGVCLVTSGPGAT 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 90 HALGGMANANMNCWPLLVIGGSSERNQETMGAFQEFPQVEACRLYTKFSARPSSIEAIPFVIEKAVRSSIYGRPGACYVD 169
Cdd:COG0028 80 NLVTGLADAYMDSVPVLAITGQVPTSLIGRGAFQEVDQVGLFRPITKWSYLVTDPEDLPEVLRRAFRIATSGRPGPVVLD 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 170 IPADFVNLQVNVNSIKYMERCMSPPISmAETSAVCTAASVIRNAKQPLLIIGKGAAYAHAEESIKKLVEQYKLPFLPTPM 249
Cdd:COG0028 160 IPKDVQAAEAEEEPAPPELRGYRPRPA-PDPEAIEEAAELLAAAKRPVILAGGGARRAGAAEELRALAERLGAPVVTTLM 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 250 GKGVVPDNHPYCVG-------AARSRALQFADVIVLFGARLNWILHFGLPPrYQPDVKFIQVDICAEELGNNVKPAVTLL 322
Cdd:COG0028 239 GKGAFPEDHPLYLGmlgmhgtPAANEALAEADLVLAVGARFDDRVTGNWDE-FAPDAKIIHIDIDPAEIGKNYPVDLPIV 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 323 GNIHAVTKQLLEELDKTPWQYPPeskWWKTLREKMKSNEAASKELASkkslPMNYYTVFYHVQEQLPRDCFVVSEGANTM 402
Cdd:COG0028 318 GDAKAVLAALLEALEPRADDRAA---WLARIAAWRAEYLAAYAADDG----PIKPQRVIAALREALPDDAIVVTDVGQHQ 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 403 DIGRTVLQNYLPRHRLDAGTFGTMGVGLGFAIAAAVVAKDRSpgqwIICVEGDSAFGFSGMEVETICRYNLPIILLVVNN 482
Cdd:COG0028 391 MWAARYLRFRRPRRFLTSGGLGTMGYGLPAAIGAKLARPDRP----VVAITGDGGFQMNLQELATAVRYGLPVKVVVLNN 466
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 483 NgiyqGFDTDTWKEMLKFQDAtavvPPMCLLPNSHYEQVMTAFGGKGYFVQTPEELQKSLRQSLAdTTKPSLINIMIEPQ 562
Cdd:COG0028 467 G----GLGMVRQWQELFYGGR----YSGTDLPNPDFAKLAEAFGAKGERVETPEELEAALEEALA-SDGPALIDVRVDPE 537
|
.
gi 93004078 563 A 563
Cdd:COG0028 538 E 538
|
|
| TPP_BZL_OCoD_HPCL |
cd02004 |
Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of ... |
377-560 |
1.65e-89 |
|
Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL cleaves the acyloin linkage of benzoin producing 2 molecules of benzaldehyde and enabling the Pseudomonas to grow on benzoin as the sole carbon and energy source. OCoD has a role in the detoxification of oxalate, catalyzing the decarboxylation of oxalyl-CoA to formate. 2-HPCL is a peroxisomal enzyme which plays a role in the alpha-oxidation of 3-methyl-branched fatty acids, catalyzing the cleavage of 2-hydroxy-3-methylacyl-CoA into formyl-CoA and a 2-methyl-branched fatty aldehyde. All these enzymes depend on Mg2+ and TPP for activity.
Pssm-ID: 238962 [Multi-domain] Cd Length: 172 Bit Score: 273.64 E-value: 1.65e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 377 YYTVFYHVQEQLPRDCFVVSEGANTMDIGRTVLQNYLPRHRLDAGTFGTMGVGLGFAIAAAVVAkdrsPGQWIICVEGDS 456
Cdd:cd02004 1 PYRVLHELQEALPDDAIIVSDGGNTMDWARYILRPRKPRHRLDAGTFGTLGVGLGYAIAAALAR----PDKRVVLVEGDG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 457 AFGFSGMEVETICRYNLPIILLVVNNNGIYQGFDTDTWkemlkfqDATAVVPPMCLLPNSHYEQVMTAFGGKGYFVQTPE 536
Cdd:cd02004 77 AFGFSGMELETAVRYNLPIVVVVGNNGGWYQGLDGQQL-------SYGLGLPVTTLLPDTRYDLVAEAFGGKGELVTTPE 149
|
170 180
....*....|....*....|....
gi 93004078 537 ELQKSLRQSLAdTTKPSLINIMIE 560
Cdd:cd02004 150 ELKPALKRALA-SGKPALINVIID 172
|
|
| PRK05858 |
PRK05858 |
acetolactate synthase; |
16-564 |
6.91e-87 |
|
acetolactate synthase;
Pssm-ID: 235629 [Multi-domain] Cd Length: 542 Bit Score: 279.68 E-value: 6.91e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 16 GAKVIAQALKTQDVEYIFGIVGIPVTEIAIAAQQLGIKYIGMRNEQAACYAASAIGYLTSRPGVCLVVSGPGLIHALGGM 95
Cdd:PRK05858 7 AGRLAARRLKAHGVDTMFTLSGGHLFPLYDGAREEGIRLIDVRHEQTAAFAAEAWAKLTRVPGVAVLTAGPGVTNGMSAM 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 96 ANANMNCWPLLVIGGSSERNQETMGAFQEFPQVEACRLYTKFSARPSSIEAIPFVIEKAVRSSIYGRPGACYVDIPADFV 175
Cdd:PRK05858 87 AAAQFNQSPLVVLGGRAPALRWGMGSLQEIDHVPFVAPVTKFAATAQSAENAGRLVDQALQAAVTPHRGPVFVDFPMDHA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 176 NLQVNVNSIKymERCMSPPISM-AETSAVCTAASVIRNAKQPLLIIGKGAAYAHAEESIKKLVEQYKLPFLPTPMGKGVV 254
Cdd:PRK05858 167 FSMADDDGRP--GALTELPAGPtPDPDALARAAGLLAEAQRPVIMAGTDVWWGHAEAALLRLAEELGIPVLMNGMGRGVV 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 255 PDNHPYCVGAARSRALQFADVIVLFGARLNWILHFGLpprYQPDVKFIQVDICAEELGNNVKPAVTLLGNIHAVTKQLLE 334
Cdd:PRK05858 245 PADHPLAFSRARGKALGEADVVLVVGVPMDFRLGFGV---FGGTAQLVHVDDAPPQRAHHRPVAAGLYGDLSAILSALAG 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 335 eldktPWQYPPE-SKWWKTLREKMKSNEAASKELASKKSLPMNYYTVFYHVQEQLPRDCFVVSEGANTMDIGRTVLQNYL 413
Cdd:PRK05858 322 -----AGGDRTDhQGWIEELRTAETAARARDAAELADDRDPIHPMRVYGELAPLLDRDAIVIGDGGDFVSYAGRYIDPYR 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 414 PRHRLDAGTFGTMGVGLGFAIAAAVVAKDRSpgqwIICVEGDSAFGFSGMEVETICRYNLPIIlLVVNNNGIYqGFDTDT 493
Cdd:PRK05858 397 PGCWLDPGPFGCLGTGPGYALAARLARPSRQ----VVLLQGDGAFGFSLMDVDTLVRHNLPVV-SVIGNNGIW-GLEKHP 470
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 93004078 494 wKEMLKFQDATAVvppmcLLPNSHYEQVMTAFGGKGYFVQTPEELQKSLRQSLaDTTKPSLINIMIEPQAT 564
Cdd:PRK05858 471 -MEALYGYDVAAD-----LRPGTRYDEVVRALGGHGELVTVPAELGPALERAF-ASGVPYLVNVLTDPSVA 534
|
|
| PRK08617 |
PRK08617 |
acetolactate synthase AlsS; |
10-557 |
3.94e-74 |
|
acetolactate synthase AlsS;
Pssm-ID: 236312 [Multi-domain] Cd Length: 552 Bit Score: 246.30 E-value: 3.94e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 10 SEEQVSGAKVIAQALKTQDVEYIFGIVGIPVTEIAIAAQQLGIKYIGMRNEQAACYAASAIGYLTSRPGVCLVVSGPGLI 89
Cdd:PRK08617 1 TDKKKYGADLVVDSLINQGVKYVFGIPGAKIDRVFDALEDSGPELIVTRHEQNAAFMAAAIGRLTGKPGVVLVTSGPGVS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 90 HALGGMANANMNCWPLLVIGGSSERNQETMGAFQEFPQVEACRLYTKFSARPSSIEAIPFVIEKAVRSSIYGRPGACYVD 169
Cdd:PRK08617 81 NLATGLVTATAEGDPVVAIGGQVKRADRLKRTHQSMDNVALFRPITKYSAEVQDPDNLSEVLANAFRAAESGRPGAAFVS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 170 IPADFVNLQVNVNSIKYMErcmSPPISMAETSAVCTAASVIRNAKQPLLIIGKGAAYAHAEESIKKLVEQYKLPFLPTPM 249
Cdd:PRK08617 161 LPQDVVDAPVTSKAIAPLS---KPKLGPASPEDINYLAELIKNAKLPVLLLGMRASSPEVTAAIRRLLERTNLPVVETFQ 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 250 GKGVVPDNHPYC----VGAARSRA----LQFADVIVLFG-------ARlNWILHfglppryqPDVKFIQVDICAEELGNN 314
Cdd:PRK08617 238 AAGVISRELEDHffgrVGLFRNQPgdelLKKADLVITIGydpieyePR-NWNSE--------GDATIIHIDVLPAEIDNY 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 315 VKPAVTLLGNIHAVTKQLLEELDktPWQYPPESKwwKTLREKMKSNEAASKELASKKSLPMNYYTVFYHVQEQLPRDCFV 394
Cdd:PRK08617 309 YQPERELIGDIAATLDLLAEKLD--GLSLSPQSL--EILEELRAQLEELAERPARLEEGAVHPLRIIRALQDIVTDDTTV 384
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 395 vseganTMDIG-------RTvLQNYLPRHRLDAGTFGTMGVGLGFAIAAAVVakdrSPGQWIICVEGDSAFGFSGMEVET 467
Cdd:PRK08617 385 ------TVDVGshyiwmaRY-FRSYEPRHLLFSNGMQTLGVALPWAIAAALV----RPGKKVVSVSGDGGFLFSAMELET 453
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 468 ICRYNLPIILLVVNNNgiyqGFDTDTWKEMLKFQDATAV-------VppmcllpnsHYEQvmtAFGGKGYFVQTPEELQK 540
Cdd:PRK08617 454 AVRLKLNIVHIIWNDG----HYNMVEFQEEMKYGRSSGVdfgpvdfV---------KYAE---SFGAKGLRVTSPDELEP 517
|
570
....*....|....*..
gi 93004078 541 SLRQSLaDTTKPSLINI 557
Cdd:PRK08617 518 VLREAL-ATDGPVVIDI 533
|
|
| PRK08322 |
PRK08322 |
acetolactate synthase large subunit; |
16-559 |
8.51e-67 |
|
acetolactate synthase large subunit;
Pssm-ID: 236239 [Multi-domain] Cd Length: 547 Bit Score: 226.63 E-value: 8.51e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 16 GAKVIAQALKTQDVEYIFGIVG---IPVTEiaiAAQQLGIKYIGMRNEQAACYAASAIGYLTSRPGVCLVVSGPGLIHAL 92
Cdd:PRK08322 3 AADLFVKCLENEGVEYIFGIPGeenLDLLE---ALRDSSIKLILTRHEQGAAFMAATYGRLTGKAGVCLSTLGPGATNLV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 93 GGMANANMNCWPLLVIGGSSERNQETMGAFQefpQVEACRLY---TKFSARPSSIEAIPFVIEKAVRSSIYGRPGACYVD 169
Cdd:PRK08322 80 TGVAYAQLGGMPMVAITGQKPIKRSKQGSFQ---IVDVVAMMaplTKWTRQIVSPDNIPEVVREAFRLAEEERPGAVHLE 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 170 IPADFVNLQVnvnSIKYMERCMSPPiSMAETSAVCTAASVIRNAKQPLLIIGKGAAYAHAEESIKKLVEQYKLPFLPTPM 249
Cdd:PRK08322 157 LPEDIAAEET---DGKPLPRSYSRR-PYASPKAIERAAEAIQAAKNPLILIGAGANRKTASKALTEFVDKTGIPFFTTQM 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 250 GKGVVPDNHPYCVGAAR-------SRALQFADVIVLFGARLnwiLHFglPP-RYQP--DVKFIQVDICAEELGNNVKPAV 319
Cdd:PRK08322 233 GKGVIPETHPLSLGTAGlsqgdyvHCAIEHADLIINVGHDV---IEK--PPfFMNPngDKKVIHINFLPAEVDPVYFPQV 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 320 TLLGNIHAVTKQLLEELDKTPWQYPPeskWWKTLREKMKSNEAaskELASKKSLPMNYYTVFYHVQEQLPRDCFVVSE-G 398
Cdd:PRK08322 308 EVVGDIANSLWQLKERLADQPHWDFP---RFLKIREAIEAHLE---EGADDDRFPMKPQRIVADLRKVMPDDDIVILDnG 381
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 399 ANTMDIGRtvlqNYLPRHR----LDAGtFGTMGVGLGFAIAAAVVAKDRSpgqwIICVEGDSAFGFSGMEVETICRYNLP 474
Cdd:PRK08322 382 AYKIWFAR----NYRAYEPntclLDNA-LATMGAGLPSAIAAKLVHPDRK----VLAVCGDGGFMMNSQELETAVRLGLP 452
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 475 IILLVVNNNgiyqGFDTDTWKEMLKFQDATAVVppmclLPNSHYEQVMTAFGGKGYFVQTPEELQKSLRQSLAdTTKPSL 554
Cdd:PRK08322 453 LVVLILNDN----AYGMIRWKQENMGFEDFGLD-----FGNPDFVKYAESYGAKGYRVESADDLLPTLEEALA-QPGVHV 522
|
....*
gi 93004078 555 INIMI 559
Cdd:PRK08322 523 IDCPV 527
|
|
| PRK08611 |
PRK08611 |
pyruvate oxidase; Provisional |
13-563 |
4.83e-63 |
|
pyruvate oxidase; Provisional
Pssm-ID: 181502 [Multi-domain] Cd Length: 576 Bit Score: 217.18 E-value: 4.83e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 13 QVSGAKVIAQALKTQDVEYIFGIVGIPVTEI--AIAAQQLGIKYIGMRNEQAACYAASAIGYLTSRPGVCLVVSGPGLIH 90
Cdd:PRK08611 3 KIKAGEALVKLLQDWGIDHVYGIPGDSIDAVvdALRKEQDKIKFIQVRHEEVAALAAAAYAKLTGKIGVCLSIGGPGAIH 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 91 ALGGMANANMNCWPLLVIGGSSERNQETMGAFQEfpqVEACRLYTK---FSARPSSIEAIPFVIEKAVRSSiYGRPGACY 167
Cdd:PRK08611 83 LLNGLYDAKMDHVPVLALAGQVTSDLLGTDFFQE---VNLEKMFEDvavYNHQIMSAENLPEIVNQAIRTA-YEKKGVAV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 168 VDIPADFVNLQVNvNSIKYMERCMSPPISMAETSAVCTAASVIRNAKQPLLIIGKGAayAHAEESIKKLVEQYKLPFLPT 247
Cdd:PRK08611 159 LTIPDDLPAQKIK-DTTNKTVDTFRPTVPSPKPKDIKKAAKLINKAKKPVILAGLGA--KHAKEELLAFAEKAKIPIIHT 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 248 PMGKGVVPDNHPYCVG-------AARSRALQFADVIVLFGArlnwilhfGLPPR-YQPD-VKFIQVDICAEELGNNVKPA 318
Cdd:PRK08611 236 LPAKGIIPDDHPYSLGnlgkigtKPAYEAMQEADLLIMVGT--------NYPYVdYLPKkAKAIQIDTDPANIGKRYPVN 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 319 VTLLGNIHAVTKQLLEELDKTPWQYPPES------KWWKTLREKMksneaaskelaSKKSLPMNYYTVFYHVQEQLPRDC 392
Cdd:PRK08611 308 VGLVGDAKKALHQLTENIKHVEDRRFLEAcqenmaKWWKWMEEDE-----------NNASTPIKPERVMAAIQKIADDDA 376
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 393 fVVSegantMDIGR-TVlqnYLPRHrLDAGT---------FGTMGVGLGFAIAAAVVAKDRSpgqwIICVEGDSAFGFSG 462
Cdd:PRK08611 377 -VLS-----VDVGTvTV---WSARY-LNLGTnqkfiisswLGTMGCGLPGAIAAKIAFPDRQ----AIAICGDGGFSMVM 442
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 463 MEVETICRYNLPIILLVVNNNGIyqgfdtdtwkEMLKF-QDATAVVPPMCLLPNSHYEQVMTAFGGKGYFVQTPEELQKS 541
Cdd:PRK08611 443 QDFVTAVKYKLPIVVVVLNNQQL----------AFIKYeQQAAGELEYAIDLSDMDYAKFAEACGGKGYRVEKAEELDPA 512
|
570 580
....*....|....*....|..
gi 93004078 542 LRQSLAdTTKPSLINIMIEPQA 563
Cdd:PRK08611 513 FEEALA-QDKPVIIDVYVDPNA 533
|
|
| PRK06276 |
PRK06276 |
acetolactate synthase large subunit; |
16-561 |
1.58e-60 |
|
acetolactate synthase large subunit;
Pssm-ID: 235766 [Multi-domain] Cd Length: 586 Bit Score: 210.77 E-value: 1.58e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 16 GAKVIAQALKTQDVEYIFGIVGIPVTEIAIAAQQLGIKYIGMRNEQAACYAASAIGYLTSRPGVCLVVSGPGLIHALGGM 95
Cdd:PRK06276 3 GAEAIIKALEAEGVKIIFGYPGGALLPFYDALYDSDLIHILTRHEQAAAHAADGYARASGKVGVCVATSGPGATNLVTGI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 96 ANANMNCWPLLVIGGSSERNQETMGAFQEfpqVEACRLY---TKFSARPSSIEAIPFVIEKAVRSSIYGRPGACYVDIPA 172
Cdd:PRK06276 83 ATAYADSSPVIALTGQVPTKLIGNDAFQE---IDALGIFmpiTKHNFQIKKPEEIPEIFRAAFEIAKTGRPGPVHIDLPK 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 173 DFVNLQVNVNSIKYMERCMSP---PISMAETSAVCTAASVIRNAKQPLLIIGKGAAYAHAEESIKKLVEQYKLPFLPTPM 249
Cdd:PRK06276 160 DVQEGELDLEKYPIPAKIDLPgykPTTFGHPLQIKKAAELIAEAERPVILAGGGVIISGASEELIELSELVKIPVCTTLM 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 250 GKGVVPDNHPYCVG-------AARSRALQFADVIVLFGARlnwilhF-----GLPPRYQPDVKFIQVDICAEELGNNVKP 317
Cdd:PRK06276 240 GKGAFPEDHPLALGmvgmhgtKAANYSVTESDVLIAIGCR------FsdrttGDISSFAPNAKIIHIDIDPAEIGKNVRV 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 318 AVTLLGNIHAVTKQLLEELDKTpwQYPPESKWWKTLREKMKSneaaSKELASKKSLPMNYYTVFYHVQEQLpRDCFVVSE 397
Cdd:PRK06276 314 DVPIVGDAKNVLRDLLAELMKK--EIKNKSEWLERVKKLKKE----SIPRMDFDDKPIKPQRVIKELMEVL-REIDPSKN 386
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 398 GANTMDIGRT------VLQNYLPRHRLDAGTFGTMGVGLGFAIAAAVVAkdrsPGQWIICVEGDSAFGFSGMEVETICRY 471
Cdd:PRK06276 387 TIITTDVGQNqmwmahFFKTSAPRSFISSGGLGTMGFGFPAAIGAKVAK----PDANVIAITGDGGFLMNSQELATIAEY 462
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 472 NLPIILLVVNNNG---IYQgfdtdtWKEMLKFQDATAV----VPPMCLLPNShyeqvmtaFGGKGYFVQTPEELQKSLRQ 544
Cdd:PRK06276 463 DIPVVICIFDNRTlgmVYQ------WQNLYYGKRQSEVhlgeTPDFVKLAES--------YGVKADRVEKPDEIKEALKE 528
|
570
....*....|....*..
gi 93004078 545 SLADtTKPSLINIMIEP 561
Cdd:PRK06276 529 AIKS-GEPYLLDIIIDP 544
|
|
| PRK06048 |
PRK06048 |
acetolactate synthase large subunit; |
10-563 |
1.16e-58 |
|
acetolactate synthase large subunit;
Pssm-ID: 180368 [Multi-domain] Cd Length: 561 Bit Score: 205.01 E-value: 1.16e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 10 SEEQVSGAKVIAQALKTQDVEYIFGIVGIPVTEIAIAAQQLGIKYIGMRNEQAACYAASAIGYLTSRPGVCLVVSGPGLI 89
Cdd:PRK06048 4 STEKMTGARAIIKCLEKEGVEVIFGYPGGAIIPVYDELYDSDLRHILVRHEQAAAHAADGYARATGKVGVCVATSGPGAT 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 90 HALGGMANANMNCWPLLVIGGSSERNQETMGAFQEFPQVEACRLYTKFSARPSSIEAIPFVIEKAVRSSIYGRPGACYVD 169
Cdd:PRK06048 84 NLVTGIATAYMDSVPIVALTGQVPRSMIGNDAFQEADITGITMPITKHNYLVQDAKDLPRIIKEAFHIASTGRPGPVLID 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 170 IPADFVNLQVNVNSIKYMERCMSPPISMAETSAVCTAASVIRNAKQPLLIIGKGAAYAHAEESIKKLVEQYKLPFLPTPM 249
Cdd:PRK06048 164 LPKDVTTAEIDFDYPDKVELRGYKPTYKGNPQQIKRAAELIMKAERPIIYAGGGVISSNASEELVELAETIPAPVTTTLM 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 250 GKGVVPDNHPYCVGAA-------RSRALQFADVIVLFGARLNWILHfGLPPRYQPDVKFIQVDICAEELGNNVKPAVTLL 322
Cdd:PRK06048 244 GIGAIPTEHPLSLGMLgmhgtkyANYAIQESDLIIAVGARFDDRVT-GKLASFAPNAKIIHIDIDPAEISKNVKVDVPIV 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 323 GNihavTKQLLEELDKTpwqypPESKWWKTLREKMKSneaaskelaSKKSLPMNYYT---------VFYHVQEQLPrDCF 393
Cdd:PRK06048 323 GD----AKQVLKSLIKY-----VQYCDRKEWLDKINQ---------WKKEYPLKYKEredvikpqyVIEQIYELCP-DAI 383
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 394 VVSE-GANTMDIGRTVLQNYlPRHRLDAGTFGTMGVGLGFAIAAAVVAKDRSpgqwIICVEGDSAFGFSGMEVETICRYN 472
Cdd:PRK06048 384 IVTEvGQHQMWAAQYFKYKY-PRTFITSGGLGTMGYGFPAAIGAKVGKPDKT----VIDIAGDGSFQMNSQELATAVQND 458
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 473 LPIILLVVNNNgiYQGFdTDTWKEMLKFQDATAVvppmCLLPNSHYEQVMTAFGGKGYFVQTPEELQKSLRQSLaDTTKP 552
Cdd:PRK06048 459 IPVIVAILNNG--YLGM-VRQWQELFYDKRYSHT----CIKGSVDFVKLAEAYGALGLRVEKPSEVRPAIEEAV-ASDRP 530
|
570
....*....|.
gi 93004078 553 SLINIMIEPQA 563
Cdd:PRK06048 531 VVIDFIVECEE 541
|
|
| ilvB |
CHL00099 |
acetohydroxyacid synthase large subunit |
13-562 |
1.99e-58 |
|
acetohydroxyacid synthase large subunit
Pssm-ID: 214363 [Multi-domain] Cd Length: 585 Bit Score: 204.93 E-value: 1.99e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 13 QVSGAKVIAQALKTQDVEYIFGIVG---IPVTEIAIAAQQLG-IKYIGMRNEQAACYAASAIGYLTSRPGVCLVVSGPGL 88
Cdd:CHL00099 9 EKTGAFALIDSLVRHGVKHIFGYPGgaiLPIYDELYAWEKKGlIKHILVRHEQGAAHAADGYARSTGKVGVCFATSGPGA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 89 IHALGGMANANMNCWPLLVIGGSSERNQETMGAFQE-------FPQVEACrlYTKFSARP-SSIEAIPFVIEKavrssiY 160
Cdd:CHL00099 89 TNLVTGIATAQMDSVPLLVITGQVGRAFIGTDAFQEvdifgitLPIVKHS--YVVRDARDiSRIVAEAFYIAK------H 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 161 GRPGACYVDIPADfVNLQ-------VNVNSIKYMERCmsPPISMAETSAVCTAASVIRNAKQPLLIIGKGAAYAHAEESI 233
Cdd:CHL00099 161 GRPGPVLIDIPKD-VGLEkfdyyppEPGNTIIKILGC--RPIYKPTIKRIEQAAKLILQSSQPLLYVGGGAIISDAHQEI 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 234 KKLVEQYKLPFLPTPMGKGVVPDNHPYCVG-------AARSRALQFADVIVLFGARlnwilhF-----GLPPRYQPDVKF 301
Cdd:CHL00099 238 TELAELYKIPVTTTLMGKGIFDEDHPLCLGmlgmhgtAYANFAVSECDLLIALGAR------FddrvtGKLDEFACNAQV 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 302 IQVDICAEELGNNVKPAVTLLGNIHAVTKQLLEELDKTPWQYPPES--KWwktlREKMKSNEAASKELASKKSLPMNYYT 379
Cdd:CHL00099 312 IHIDIDPAEIGKNRIPQVAIVGDVKKVLQELLELLKNSPNLLESEQtqAW----RERINRWRKEYPLLIPKPSTSLSPQE 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 380 VFYHVQEQLPRDCFvvseganTMDIGRTVL--QNYL---PRHRLDAGTFGTMGVGLGFAIAAAVVakdrSPGQWIICVEG 454
Cdd:CHL00099 388 VINEISQLAPDAYF-------TTDVGQHQMwaAQFLkckPRKWLSSAGLGTMGYGLPAAIGAQIA----HPNELVICISG 456
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 455 DSAFGFSGMEVETICRYNLPIILLVVNNNgiYQGFdTDTWKE-----------MLKFQdatavvppmcllPNshYEQVMT 523
Cdd:CHL00099 457 DASFQMNLQELGTIAQYNLPIKIIIINNK--WQGM-VRQWQQafygeryshsnMEEGA------------PD--FVKLAE 519
|
570 580 590
....*....|....*....|....*....|....*....
gi 93004078 524 AFGGKGYFVQTPEELQKSLRQSLaDTTKPSLINIMIEPQ 562
Cdd:CHL00099 520 AYGIKGLRIKSRKDLKSSLKEAL-DYDGPVLIDCQVIED 557
|
|
| PRK08979 |
PRK08979 |
acetolactate synthase 3 large subunit; |
12-576 |
2.13e-58 |
|
acetolactate synthase 3 large subunit;
Pssm-ID: 181602 [Multi-domain] Cd Length: 572 Bit Score: 204.67 E-value: 2.13e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 12 EQVSGAKVIAQALKTQDVEYIFGIVGIPVTEIAIAAQQL-GIKYIGMRNEQAACYAASAIGYLTSRPGVCLVVSGPGLIH 90
Cdd:PRK08979 2 EMLSGASMIVRSLIDEGVKHIFGYPGGSVLDIYDALHEKsGIEHILVRHEQAAVHMADGYARATGKVGVVLVTSGPGATN 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 91 ALGGMANANMNCWPLLVIGGSSERNQETMGAFQEFPQVEACRLYTKFSARPSSIEAIPFVIEKAVRSSIYGRPGACYVDI 170
Cdd:PRK08979 82 TITGIATAYMDSIPMVVLSGQVPSNLIGNDAFQECDMIGISRPVVKHSFLVKDAEDIPEIIKKAFYIASTGRPGPVVIDL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 171 PADFVNLQVnVNSIKYME----RCMSPPISmAETSAVCTAASVIRNAKQPLLIIGKGAAYAHAEESIKKLVEQYKLPFLP 246
Cdd:PRK08979 162 PKDCLNPAI-LHPYEYPEsikmRSYNPTTS-GHKGQIKRGLQALLAAKKPVLYVGGGAIISGADKQILQLAEKLNLPVVS 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 247 TPMGKGVVPDNHPYCVGA-------ARSRALQFADVIVLFGARLNWILHFGLpPRYQPDVKFIQVDICAEELGNNVKPAV 319
Cdd:PRK08979 240 TLMGLGAFPGTHKNSLGMlgmhgryEANMAMHNADLIFGIGVRFDDRTTNNL-EKYCPNATILHIDIDPSSISKTVRVDI 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 320 TLLGNIHAVTKQLLEELDKTPWQYPPES--KWWKTLrEKMKSNEAASKELASKKSLPMNYYTVFYHVQEQlprDCFVVSe 397
Cdd:PRK08979 319 PIVGSADKVLDSMLALLDESGETNDEAAiaSWWNEI-EVWRSRNCLAYDKSSERIKPQQVIETLYKLTNG---DAYVAS- 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 398 gantmDIGRTVLQNYL------PRHRLDAGTFGTMGVGLgfaiAAAVVAKDRSPGQWIICVEGDSAFGFSGMEVETICRY 471
Cdd:PRK08979 394 -----DVGQHQMFAALyypfdkPRRWINSGGLGTMGFGL----PAAMGVKFAMPDETVVCVTGDGSIQMNIQELSTALQY 464
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 472 NLPIILLVVNN----------NGIYQGFDTDTWkemlkfqdatavvppMCLLPNshYEQVMTAFGGKGYFVQTPEELQKS 541
Cdd:PRK08979 465 DIPVKIINLNNrflgmvkqwqDMIYQGRHSHSY---------------MDSVPD--FAKIAEAYGHVGIRISDPDELESG 527
|
570 580 590 600
....*....|....*....|....*....|....*....|..
gi 93004078 542 LRQSLADTTKPSLINIMIE------PQATR-KAQDFHWLTRS 576
Cdd:PRK08979 528 LEKALAMKDRLVFVDINVDetehvyPMQIRgGAMNEMWLSKT 569
|
|
| PRK08527 |
PRK08527 |
acetolactate synthase large subunit; |
13-560 |
1.93e-57 |
|
acetolactate synthase large subunit;
Pssm-ID: 181458 [Multi-domain] Cd Length: 563 Bit Score: 201.87 E-value: 1.93e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 13 QVSGAKVIAQALKTQDVEYIFGIVGIPVT----EIAiaaQQLGIKYIGMRNEQAACYAASAIGYLTSRPGVCLVVSGPGL 88
Cdd:PRK08527 2 KLSGSQMVCEALKEEGVKVVFGYPGGAILniydEIY---KQNYFKHILTRHEQAAVHAADGYARASGKVGVAIVTSGPGF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 89 IHALGGMANANMNCWPLLVIGGSSERNQETMGAFQEFPQVEACRLYTKFSARPSSIEAIPFVIEKAVRSSIYGRPGACYV 168
Cdd:PRK08527 79 TNAVTGLATAYMDSIPLVLISGQVPNSLIGTDAFQEIDAVGISRPCVKHNYLVKSIEELPRILKEAFYIARSGRPGPVHI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 169 DIPADfvnLQVNVNSIKYMERCMSP---PISMAETSAVCTAASVIRNAKQPLLIIGKGAAYAHAEESIKKLVEQYKLPFL 245
Cdd:PRK08527 159 DIPKD---VTATLGEFEYPKEISLKtykPTYKGNSRQIKKAAEAIKEAKKPLFYLGGGAILSNASEEIRELVKKTGIPAV 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 246 PTPMGKGVVPDNHPYCVGA-------ARSRALQFADVIVLFGARlnwilhF-----GLPPRYQPDVKFIQVDICAEELGN 313
Cdd:PRK08527 236 ETLMARGVLRSDDPLLLGMlgmhgsyAANMAMSECDLLISLGAR------FddrvtGKLSEFAKHAKIIHVDIDPSSISK 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 314 NVKPAVTLLGNIHAVTKQLLEEL-DKTPWQYPPeskWWKTLREKMKSNEAASKElaSKKSLPMNYytVFYHVQEQLPRDC 392
Cdd:PRK08527 310 IVNADYPIVGDLKNVLKEMLEELkEENPTTYKE---WREILKRYNELHPLSYED--SDEVLKPQW--VIERVGELLGDDA 382
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 393 FVvseganTMDIGRT---VLQNY---LPRHRLDAGTFGTMGVGLGFAIAAAVVAKDRSpgqwIICVEGDSAFGFSGMEVE 466
Cdd:PRK08527 383 II------STDVGQHqmwVAQFYpfnYPRQLATSGGLGTMGYGLPAALGAKLAVPDKV----VINFTGDGSILMNIQELM 452
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 467 TICRYNLPIILLVVNNN--GIYQGFDTDTWKEMLKFQDATavvppmcLLPNshYEQVMTAFGGKGYFVQTPEELQKSLRQ 544
Cdd:PRK08527 453 TAVEYKIPVINIILNNNflGMVRQWQTFFYEERYSETDLS-------TQPD--FVKLAESFGGIGFRVTTKEEFDKALKE 523
|
570
....*....|....*.
gi 93004078 545 SLaDTTKPSLINIMIE 560
Cdd:PRK08527 524 AL-ESDKVALIDVKID 538
|
|
| PRK07979 |
PRK07979 |
acetolactate synthase 3 large subunit; |
12-555 |
3.78e-57 |
|
acetolactate synthase 3 large subunit;
Pssm-ID: 181185 [Multi-domain] Cd Length: 574 Bit Score: 201.23 E-value: 3.78e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 12 EQVSGAKVIAQALKTQDVEYIFGIVGIPVTEIAIAAQQLG-IKYIGMRNEQAACYAASAIGYLTSRPGVCLVVSGPGLIH 90
Cdd:PRK07979 2 EMLSGAEMVVRSLIDQGVKQVFGYPGGAVLDIYDALHTVGgIDHVLVRHEQAAVHMADGLARATGEVGVVLVTSGPGATN 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 91 ALGGMANANMNCWPLLVIGGSSERNQETMGAFQEFPQVEACRLYTKFSARPSSIEAIPFVIEKAVRSSIYGRPGACYVDI 170
Cdd:PRK07979 82 AITGIATAYMDSIPLVVLSGQVATSLIGYDAFQECDMVGISRPVVKHSFLVKQTEDIPQVLKKAFWLAASGRPGPVVVDL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 171 PADFVNLQVNVNSI---KYMERCMSPPISmAETSAVCTAASVIRNAKQPLLIIGKGAAYAHAEESIKKLVEQYKLPFLPT 247
Cdd:PRK07979 162 PKDILNPANKLPYVwpeSVSMRSYNPTTQ-GHKGQIKRALQTLVAAKKPVVYVGGGAINAACHQQLKELVEKLNLPVVSS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 248 PMGKGVVPDNHPYCVGA-------ARSRALQFADVIVLFGARLNWILHFGLpPRYQPDVKFIQVDICAEELGNNVKPAVT 320
Cdd:PRK07979 241 LMGLGAFPATHRQSLGMlgmhgtyEANMTMHNADVIFAVGVRFDDRTTNNL-AKYCPNATVLHIDIDPTSISKTVTADIP 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 321 LLGNIHAVTKQLLEELDKTPWQYPPES--KWWKTLrEKMKSNEAASKELASKKSLPMNYYTVFYHVQEQlprDCFVVSeg 398
Cdd:PRK07979 320 IVGDARQVLEQMLELLSQESAHQPLDEirDWWQQI-EQWRARQCLKYDTHSEKIKPQAVIETLWRLTKG---DAYVTS-- 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 399 antmDIGRTVLQNYL------PRHRLDAGTFGTMGVGLgfaiAAAVVAKDRSPGQWIICVEGDSAFGFSGMEVETICRYN 472
Cdd:PRK07979 394 ----DVGQHQMFAALyypfdkPRRWINSGGLGTMGFGL----PAALGVKMALPEETVVCVTGDGSIQMNIQELSTALQYE 465
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 473 LPIilLVVNNNGIYQGFdTDTWKEMLKFQDATAVVppMCLLPNshYEQVMTAFGGKGYFVQTPEELQKSLRQSLADTTKP 552
Cdd:PRK07979 466 LPV--LVLNLNNRYLGM-VKQWQDMIYSGRHSQSY--MQSLPD--FVRLAEAYGHVGIQISHPDELESKLSEALEQVRNN 538
|
...
gi 93004078 553 SLI 555
Cdd:PRK07979 539 RLV 541
|
|
| PRK06456 |
PRK06456 |
acetolactate synthase large subunit; |
15-563 |
2.63e-56 |
|
acetolactate synthase large subunit;
Pssm-ID: 180569 [Multi-domain] Cd Length: 572 Bit Score: 198.91 E-value: 2.63e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 15 SGAKVIAQALKTQDVEYIFGIVGIPVTEIAIA----AQQLGIKYIGMRNEQAACYAASAIGYLTSRPGVCLVVSGPGLIH 90
Cdd:PRK06456 3 TGARILVDSLKREGVKVIFGIPGLSNMQIYDAfvedLANGELRHVLMRHEQAAAHAADGYARASGVPGVCTATSGPGTTN 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 91 ALGGMANANMNCWPLLVIGGSSERNQETMGAFQEFPQVEACRLYTKFSARPSSIEAIPFVIEKAVRSSIYGRPGACYVDI 170
Cdd:PRK06456 83 LVTGLITAYWDSSPVIAITGQVPRSVMGKMAFQEADAMGVFENVTKYVIGIKRIDEIPQWIKNAFYIATTGRPGPVVIDI 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 171 PADFVNLQvnVNSIKYMERCMSPPI----SMAETSAVCTAASVIRNAKQPLLIIGKGAAYAHAEESIKKLVEQYKLPFLP 246
Cdd:PRK06456 163 PRDIFYEK--MEEIKWPEKPLVKGYrdfpTRIDRLALKKAAEILINAERPIILVGTGVVWSNATPEVLELAELLHIPIVS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 247 TPMGKGVVPDNHPYCVG-------AARSRALQFADVIVLFGARLNWILHFGLPPRYQPDVKFIQVDICAEELGNNVKPAV 319
Cdd:PRK06456 241 TFPGKTAIPHDHPLYFGpmgyygrAEASMAALESDAMLVVGARFSDRTFTSYDEMVETRKKFIMVNIDPTDGEKAIKVDV 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 320 TLLGNihavTKQLLEELDKTPWQYPPE---SKWWKTLREkmksneaaSKElaskkslpmnYYTVFYHVQEQ--------- 387
Cdd:PRK06456 321 GIYGN----AKIILRELIKAITELGQKrdrSAWLKRVKE--------YKE----------YYSQFYYTEENgklkpwkim 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 388 ------LPRDCfVVSEGANTMDIGRTVLQNYL-PRHRLDAGTFGTMGVGLgfaiAAAVVAKDRSPGQWIICVEGDSAFGF 460
Cdd:PRK06456 379 ktirqaLPRDA-IVTTGVGQHQMWAEVFWEVLePRTFLTSSGMGTMGFGL----PAAMGAKLARPDKVVVDLDGDGSFLM 453
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 461 SGMEVETICRYNLPIILLVvnnngiyqgFDTDTWKEMLKFQDA--TAVVPPMCLLPNSHYEQVMTAFGGKGYFVQTPEEL 538
Cdd:PRK06456 454 TGTNLATAVDEHIPVISVI---------FDNRTLGLVRQVQDLffGKRIVGVDYGPSPDFVKLAEAFGALGFNVTTYEDI 524
|
570 580
....*....|....*....|....*
gi 93004078 539 QKSLRQSLADTTkPSLINIMIEPQA 563
Cdd:PRK06456 525 EKSLKSAIKEDI-PAVIRVPVDKEE 548
|
|
| PRK08266 |
PRK08266 |
hypothetical protein; Provisional |
12-560 |
3.68e-56 |
|
hypothetical protein; Provisional
Pssm-ID: 181337 [Multi-domain] Cd Length: 542 Bit Score: 197.93 E-value: 3.68e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 12 EQVSGAKVIAQALKTQDVEYIFGIVGIPVTEI--AIAAQQLGIKYIGMRNEQAACYAASAIGYLTSRPGVCLVVSGPGLI 89
Cdd:PRK08266 2 TTMTGGEAIVAGLVAHGVDTVFGLPGAQLYWLfdALYKAGDRIRVIHTRHEQAAGYMAFGYARSTGRPGVCSVVPGPGVL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 90 HALGGMANANMNCWPLLVIGGS--SERNQETMGAFQEFP-QVEACRLYTKFSARPSSIEAIPFVIEKAVRSSIYGRPGAC 166
Cdd:PRK08266 82 NAGAALLTAYGCNSPVLCLTGQipSALIGKGRGHLHEMPdQLATLRSFTKWAERIEHPSEAPALVAEAFQQMLSGRPRPV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 167 YVDIPADFVNLQVNVNSIKYMERCMSPPIsmaETSAVCTAASVIRNAKQPLLIIGKGAAYAHAEesIKKLVEQYKLPFLP 246
Cdd:PRK08266 162 ALEMPWDVFGQRAPVAAAPPLRPAPPPAP---DPDAIAAAAALIAAAKNPMIFVGGGAAGAGEE--IRELAEMLQAPVVA 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 247 TPMGKGVVPDNHP-YCVGAARSRALQFADVIVLFGARLnwILHFGLPPrYQPD-VKFIQVDICAEELGnNVKPAVTLLGN 324
Cdd:PRK08266 237 FRSGRGIVSDRHPlGLNFAAAYELWPQTDVVIGIGSRL--ELPTFRWP-WRPDgLKVIRIDIDPTEMR-RLKPDVAIVAD 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 325 IHAVTKQLLEELDKTPWQYPPEskwwktlREKMKSNEAASKELASKKSLPMNYYTVfyhVQEQLPRDCFVVSEGANTMDI 404
Cdd:PRK08266 313 AKAGTAALLDALSKAGSKRPSR-------RAELRELKAAARQRIQAVQPQASYLRA---IREALPDDGIFVDELSQVGFA 382
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 405 GRTVLQNYLPRHRLDAGTFGTMGVGLGFAIAAAVVAKDRSpgqwIICVEGDSAFGFSGMEVETICRYNLPIILLVVNNNG 484
Cdd:PRK08266 383 SWFAFPVYAPRTFVTCGYQGTLGYGFPTALGAKVANPDRP----VVSITGDGGFMFGVQELATAVQHNIGVVTVVFNNNA 458
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 485 ----------IYQG--FDTDtwkemlkfqdatavvppmclLPNSHYEQVMTAFGGKGYFVQTPEELQKSLRQSLAdTTKP 552
Cdd:PRK08266 459 ygnvrrdqkrRFGGrvVASD--------------------LVNPDFVKLAESFGVAAFRVDSPEELRAALEAALA-HGGP 517
|
....*...
gi 93004078 553 SLINIMIE 560
Cdd:PRK08266 518 VLIEVPVP 525
|
|
| PRK07418 |
PRK07418 |
acetolactate synthase large subunit; |
12-557 |
5.51e-56 |
|
acetolactate synthase large subunit;
Pssm-ID: 236014 [Multi-domain] Cd Length: 616 Bit Score: 199.12 E-value: 5.51e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 12 EQVSGAKVIAQALKTQDVEYIFGIVG---IPV-TEIAIAAQQLGIKYIGMRNEQAACYAASAIGYLTSRPGVCLVVSGPG 87
Cdd:PRK07418 17 QRATGAYALMDSLKRHGVKHIFGYPGgaiLPIyDELYKAEAEGWLKHILVRHEQGAAHAADGYARATGKVGVCFGTSGPG 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 88 LIHALGGMANANMNCWPLLVIGGSSERNQETMGAFQE-------FPQVeacrlytKFS------ARPSSIEAIPFVIEka 154
Cdd:PRK07418 97 ATNLVTGIATAQMDSVPMVVITGQVPRPAIGTDAFQEtdifgitLPIV-------KHSyvvrdpSDMARIVAEAFHIA-- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 155 vrSSiyGRPGACYVDIPADfVNLQ------VNVNSIKYmeRCMSPPISmAETSAVCTAASVIRNAKQPLLIIGKGAAYAH 228
Cdd:PRK07418 168 --SS--GRPGPVLIDIPKD-VGQEefdyvpVEPGSVKP--PGYRPTVK-GNPRQINAALKLIEEAERPLLYVGGGAISAG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 229 AEESIKKLVEQYKLPFLPTPMGKGVVPDNHPYCVG-------AARSRALQFADVIVLFGARlnwilhF-----GLPPRYQ 296
Cdd:PRK07418 240 AHAELKELAERFQIPVTTTLMGKGAFDEHHPLSVGmlgmhgtAYANFAVTECDLLIAVGAR------FddrvtGKLDEFA 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 297 PDVKFIQVDICAEELGNNVKPAVTLLGNIHAVTKQLLEELDKTPWQyPPESKW------WKT---LREKMKSNEAASKEl 367
Cdd:PRK07418 314 SRAKVIHIDIDPAEVGKNRRPDVPIVGDVRKVLVKLLERSLEPTTP-PRTQAWlerinrWKQdypLVVPPYEGEIYPQE- 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 368 askkslpmnyytVFYHVQEQLPrDCFVvseganTMDIGRTVL--QNYL---PRHRLDAGTFGTMGVGLGFAIAAAVVAKD 442
Cdd:PRK07418 392 ------------VLLAVRDLAP-DAYY------TTDVGQHQMwaAQFLrngPRRWISSAGLGTMGFGMPAAMGVKVALPD 452
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 443 RSpgqwIICVEGDSAFGFSGMEVETICRYNLPIILLVVNNNgiYQGFdTDTWKEmlKFQD----ATAVVPPMcllPNshY 518
Cdd:PRK07418 453 EE----VICIAGDASFLMNIQELGTLAQYGINVKTVIINNG--WQGM-VRQWQE--SFYGerysASNMEPGM---PD--F 518
|
570 580 590
....*....|....*....|....*....|....*....
gi 93004078 519 EQVMTAFGGKGYFVQTPEELQKSLRQSLAdTTKPSLINI 557
Cdd:PRK07418 519 VKLAEAFGVKGMVISERDQLKDAIAEALA-HDGPVLIDV 556
|
|
| TPP_PYR_POX_like |
cd07035 |
Pyrimidine (PYR) binding domain of POX and related proteins; Thiamine pyrophosphate (TPP ... |
19-172 |
7.53e-55 |
|
Pyrimidine (PYR) binding domain of POX and related proteins; Thiamine pyrophosphate (TPP family), pyrimidine (PYR) binding domain of pyruvate oxidase (POX) and related protiens subfamily. The PYR domain is found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. TPP binds in the cleft formed by a PYR domain and a PP domain. The PYR domain, binds the aminopyrimidine ring of TPP, the PP domain binds the diphosphate residue. A polar interaction between the conserved glutamate of the PYR domain and the N1' of the TPP aminopyrimidine ring is shared by most TPP-dependent enzymes, and participates in the activation of TPP. For glyoxylate carboligase, which belongs to this subfamily, but lacks this conserved glutamate, the rate of the initial TPP activation step is reduced but the ensuing steps of the enzymic reaction proceed efficiently. The PYR and PP domains have a common fold, but do not share strong sequence conservation. The PP domain is not included in this sub-family. Most TPP-dependent enzymes have the PYR and PP domains on the same subunit although these domains can be alternatively arranged in the primary structure. TPP-dependent enzymes are multisubunit proteins, the smallest catalytic unit being a dimer-of-active sites, for many the active sites lie between PP and PYR domains on different subunits. POX decarboxylates pyruvate, producing hydrogen peroxide and the energy-storage metabolite acetylphosphate. This subfamily includes pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC catalyzes the conversion of pyruvate to acetaldehyde and CO2 in alcoholic fermentation. IPDC plays a role in the indole-3-pyruvic acid (IPA) pathway in plants and various plant-associated bacteria, it catalyzes the decarboxylation of IPA to IAA. This subfamily also includes the large catalytic subunit of acetohydroxyacid synthase (AHAS). AHAS catalyzes the condensation of two molecules of pyruvate to give the acetohydroxyacid, 2-acetolactate, a precursor of the branched chain amino acids, valine and leucine. AHAS also catalyzes the condensation of pyruvate and 2-ketobutyrate to form 2-aceto-2-hydroxybutyrate in isoleucine biosynthesis. Methanococcus jannaschii sulfopyruvate decarboxylase (MjComDE) and phosphonopyruvate decarboxylase (PpyrDc) also belong to this subfamily. PpyrDc is a homotrimeric enzyme having the PP and PYR domains tandemly arranged on the same subunit. It functions in the biosynthesis of C-P compounds such as bialaphos tripeptide in Streptomyces hygroscopicus. MjComDE is a dodecamer having the PYR and PP domains on different subunits, it has six alpha (PYR/ComD) subunits and six beta (PP/ComE) subunits. MjComDE catalyzes the decarboxylation of sulfopyruvic acid to sulfoacetaldehyde in the coenzyme M pathway.
Pssm-ID: 132918 [Multi-domain] Cd Length: 155 Bit Score: 182.73 E-value: 7.53e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 19 VIAQALKTQDVEYIFGIVGIPVTEIAIAAQQLGIKYIGMRNEQAACYAASAIGYLTSRPGVCLVVSGPGLIHALGGMANA 98
Cdd:cd07035 2 ALVEALKAEGVDHVFGVPGGAILPLLDALARSGIRYILVRHEQGAVGMADGYARATGKPGVVLVTSGPGLTNAVTGLANA 81
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 93004078 99 NMNCWPLLVIGGSSERNQETMGAFQEFPQVEACRLYTKFSARPSSIEAIPFVIEKAVRSSIYGRPGACYVDIPA 172
Cdd:cd07035 82 YLDSIPLLVITGQRPTAGEGRGAFQEIDQVALFRPITKWAYRVTSPEEIPEALRRAFRIALSGRPGPVALDLPK 155
|
|
| PRK06154 |
PRK06154 |
thiamine pyrophosphate-requiring protein; |
15-558 |
3.52e-54 |
|
thiamine pyrophosphate-requiring protein;
Pssm-ID: 235718 [Multi-domain] Cd Length: 565 Bit Score: 193.10 E-value: 3.52e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 15 SGAKVIAQALKTQDVEYIFGIvgiPVTEIAIAAQQLGIKYIGMRNEQAACYAASAIGYLTS--RPGVCLVVSGPGLIHAL 92
Cdd:PRK06154 21 KVAEAVAEILKEEGVELLFGF---PVNELFDAAAAAGIRPVIARTERVAVHMADGYARATSgeRVGVFAVQYGPGAENAF 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 93 GGMANANMNCWPLLVIGGSSERNQETMGAfqEFPQVEACRLYTKFSARPSSIEAIPFVIEKAVRSSIYGRPGACYVDIPA 172
Cdd:PRK06154 98 GGVAQAYGDSVPVLFLPTGYPRGSTDVAP--NFESLRNYRHITKWCEQVTLPDEVPELMRRAFTRLRNGRPGPVVLELPV 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 173 DFVNLQVNVNSIKYmercmSPP---ISMAETSAVCTAASVIRNAKQPLLIIGKGAAYAHAEESIKKLVEQYKLPFLPTPM 249
Cdd:PRK06154 176 DVLAEELDELPLDH-----RPSrrsRPGADPVEVVEAAALLLAAERPVIYAGQGVLYAQATPELKELAELLEIPVMTTLN 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 250 GKGVVPDNHPYCVGAArSRA--------LQFADVIVLFGARLNWIlHFGLP-PRyqpDVKFIQVDICAEELGNNVKPAVT 320
Cdd:PRK06154 251 GKSAFPEDHPLALGSG-GRArpatvahfLREADVLFGIGCSLTRS-YYGLPmPE---GKTIIHSTLDDADLNKDYPIDHG 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 321 LLGNIHAVTKQLLEELDKTPWQYPPESKwwKTLREKMKSNEAASKELASK---KSLPMNYYTVFYHVQEQL-PRDCFVVS 396
Cdd:PRK06154 326 LVGDAALVLKQMIEELRRRVGPDRGRAQ--QVAAEIEAVRAAWLAKWMPKltsDSTPINPYRVVWELQHAVdIKTVIITH 403
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 397 EGANTMDIGRTVLQNYLPRHRLDAGTFGTMGVGLGFAIAAAVVakdrSPGQWIICVEGDSAFGFSGMEVETICRYNLPIi 476
Cdd:PRK06154 404 DAGSPRDQLSPFYVASRPGSYLGWGKTTQLGYGLGLAMGAKLA----RPDALVINLWGDAAFGMTGMDFETAVRERIPI- 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 477 LLVVNNNGIYQGFDTDTWKEMLKFQdATAVvppmcllpNSHYEQVMTAFGGKGYFVQTPEELQKSLRQSL--ADTTKPSL 554
Cdd:PRK06154 479 LTILLNNFSMGGYDKVMPVSTTKYR-ATDI--------SGDYAAIARALGGYGERVEDPEMLVPALLRALrkVKEGTPAL 549
|
....
gi 93004078 555 INIM 558
Cdd:PRK06154 550 LEVI 553
|
|
| PRK06725 |
PRK06725 |
acetolactate synthase large subunit; |
12-547 |
3.33e-53 |
|
acetolactate synthase large subunit;
Pssm-ID: 180672 [Multi-domain] Cd Length: 570 Bit Score: 190.56 E-value: 3.33e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 12 EQVSGAKVIAQALKTQDVEYIFGIVGIPVTEIAIAAQQLGIKYIGMRNEQAACYAASAIGYLTSRPGVCLVVSGPGLIHA 91
Cdd:PRK06725 13 EEVTGAGHVIQCLKKLGVTTVFGYPGGAILPVYDALYESGLKHILTRHEQAAIHAAEGYARASGKVGVVFATSGPGATNL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 92 LGGMANANMNCWPLLVIGGSSERNQETMGAFQEFPQVEACRLYTKFSARPSSIEAIPFVIEKAVRSSIYGRPGACYVDIP 171
Cdd:PRK06725 93 VTGLADAYMDSIPLVVITGQVATPLIGKDGFQEADVVGITVPVTKHNYQVRDVNQLSRIVQEAFYIAESGRPGPVLIDIP 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 172 ADFVNLQVnvnSIKYMERCMSP---PISMAETSAVCTAASVIRNAKQPLLIIGKGAAYAHAEESIKKLVEQYKLPFLPTP 248
Cdd:PRK06725 173 KDVQNEKV---TSFYNEVVEIPgykPEPRPDSMKLREVAKAISKAKRPLLYIGGGVIHSGGSEELIEFARENRIPVVSTL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 249 MGKGVVPDNHPYCVGA-------ARSRALQFADVIVLFGARLNWILHfGLPPRYQPDVKFIQVDICAEELGNNVKPAVTL 321
Cdd:PRK06725 250 MGLGAYPPGDPLFLGMlgmhgtyAANMAVTECDLLLALGVRFDDRVT-GKLELFSPHSKKVHIDIDPSEFHKNVAVEYPV 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 322 LGNIHAVTKQLLEELDKTPW-QYPPESKWWKtlREKMKSNEAASKELASKKSLPMnyytvfyhVQEQLPRDCFVVSEGAN 400
Cdd:PRK06725 329 VGDVKKALHMLLHMSIHTQTdEWLQKVKTWK--EEYPLSYKQKESELKPQHVINL--------VSELTNGEAIVTTEVGQ 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 401 TMDIGRTVLQNYLPRHRLDAGTFGTMGVGLGFAIAAAvVAKdrsPGQWIICVEGDSAFGFSGMEVETICRYNLPIILLVV 480
Cdd:PRK06725 399 HQMWAAHFYKAKNPRTFLTSGGLGTMGFGFPAAIGAQ-LAK---EEELVICIAGDASFQMNIQELQTIAENNIPVKVFII 474
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 481 NNNgiYQGFdTDTWKEML---KFQDATAVVPpmcllpnsHYEQVMTAFGGKGYFVQTPEELQKSLRQSLA 547
Cdd:PRK06725 475 NNK--FLGM-VRQWQEMFyenRLSESKIGSP--------DFVKVAEAYGVKGLRATNSTEAKQVMLEAFA 533
|
|
| PRK06882 |
PRK06882 |
acetolactate synthase 3 large subunit; |
12-560 |
3.35e-53 |
|
acetolactate synthase 3 large subunit;
Pssm-ID: 168717 [Multi-domain] Cd Length: 574 Bit Score: 190.51 E-value: 3.35e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 12 EQVSGAKVIAQALKTQDVEYIFGIVGIPVTEIAIAAQQLG-IKYIGMRNEQAACYAASAIGYLTSRPGVCLVVSGPGLIH 90
Cdd:PRK06882 2 KKLSGAEMVVQSLRDEGVEYVFGYPGGSVLDIYDAIHTLGgIEHVLVRHEQAAVHMADGYARSTGKVGCVLVTSGPGATN 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 91 ALGGMANANMNCWPLLVIGGSSERNQETMGAFQEFPQVEACRLYTKFSARPSSIEAIPFVIEKAVRSSIYGRPGACYVDI 170
Cdd:PRK06882 82 AITGIATAYTDSVPLVILSGQVPSNLIGTDAFQECDMLGISRPVVKHSFIVKNAEDIPSTIKKAFYIASTGRPGPVVIDI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 171 PADFVNlQVNVNSIKYME----RCMSPPISmAETSAVCTAASVIRNAKQPLLIIGKGAAYAHAEESIKKLVEQYKLPFLP 246
Cdd:PRK06882 162 PKDMVN-PANKFTYEYPEevslRSYNPTVQ-GHKGQIKKALKALLVAKKPVLFVGGGVITAECSEQLTQFAQKLNLPVTS 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 247 TPMGKGVVPDNHPYCVGA-------ARSRALQFADVIVLFGARLNWILHFGLpPRYQPDVKFIQVDICAEELGNNVKPAV 319
Cdd:PRK06882 240 SLMGLGAYPSTDKQFLGMlgmhgtyEANNAMHESDLILGIGVRFDDRTTNNL-AKYCPNAKVIHIDIDPTSISKNVPAYI 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 320 TLLGNIHAVTKQ---LLEELDKTPWQYPPESkWWKTLREkMKSNEAASKELASKKSLPMNYYTVFYHVQEQlprDCFVVS 396
Cdd:PRK06882 319 PIVGSAKNVLEEflsLLEEENLAKSQTDLTA-WWQQINE-WKAKKCLEFDRTSDVIKPQQVVEAIYRLTNG---DAYVAS 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 397 egantmDIGRTVLQNYL------PRHRLDAGTFGTMGVGLgfaiAAAVVAKDRSPGQWIICVEGDSAFGFSGMEVETICR 470
Cdd:PRK06882 394 ------DVGQHQMFAALhypfdkPRRWINSGGAGTMGFGL----PAAIGVKFAHPEATVVCVTGDGSIQMNIQELSTAKQ 463
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 471 YNLPIILLVVNNNgiYQGFdTDTWKEMLKFQDATAVVppMCLLPNshYEQVMTAFGGKGYFVQTPEELQKSLRQSLADTT 550
Cdd:PRK06882 464 YDIPVVIVSLNNR--FLGM-VKQWQDLIYSGRHSQVY--MNSLPD--FAKLAEAYGHVGIQIDTPDELEEKLTQAFSIKD 536
|
570
....*....|
gi 93004078 551 KPSLINIMIE 560
Cdd:PRK06882 537 KLVFVDVNVD 546
|
|
| PRK07525 |
PRK07525 |
sulfoacetaldehyde acetyltransferase; Validated |
29-559 |
3.75e-53 |
|
sulfoacetaldehyde acetyltransferase; Validated
Pssm-ID: 236042 [Multi-domain] Cd Length: 588 Bit Score: 190.59 E-value: 3.75e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 29 VEYIFGIVG---IPVTEIAIAAqqlGIKYIGMRNEQAACYAASAIGYLTSRPGVCLVVSGPGLIHALGGMANANMNCWPL 105
Cdd:PRK07525 21 ITHAFGIIGsafMDASDLFPPA---GIRFIDVAHEQNAGHMADGYTRVTGRMGMVIGQNGPGITNFVTAVATAYWAHTPV 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 106 LVIggSSERNQETMG--AFQEFPQVEACRLYTKFSAR---PSSI-EAIPFVIEKAVRSSiygrpGACYVDIPADFVNLQV 179
Cdd:PRK07525 98 VLV--TPQAGTKTIGqgGFQEAEQMPMFEDMTKYQEEvrdPSRMaEVLNRVFDKAKRES-----GPAQINIPRDYFYGVI 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 180 NVN--SIKYMERCMSPPISMAEtsavctAASVIRNAKQPLLIIGKGAAYAHAEESIKKLVEQYKLPFLPTPMGKGVVPDN 257
Cdd:PRK07525 171 DVEipQPVRLERGAGGEQSLAE------AAELLSEAKFPVILSGAGVVLSDAIEECKALAERLDAPVACGYLHNDAFPGS 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 258 HP-------YCVGAARSRALQFADVIVLFGARLNwilHFGLPPRYQ----P-DVKFIQVDICAEELGNNVKPAVTLLGNI 325
Cdd:PRK07525 245 HPlwvgplgYNGSKAAMELIAKADVVLALGTRLN---PFGTLPQYGidywPkDAKIIQVDINPDRIGLTKKVSVGICGDA 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 326 HAVTKQLLEEL-DKTPWQYPPE----------SKWWKTLREKMKSNEAAS----KELASKKSLPMNYYTVFYHVQEQLPR 390
Cdd:PRK07525 322 KAVARELLARLaERLAGDAGREerkaliaaekSAWEQELSSWDHEDDDPGtdwnEEARARKPDYMHPRQALREIQKALPE 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 391 DCFVVSEGANTMDIGRTVLQNYLPRHRLDAGTFGTMGVGLGFAIAAAVVAKDRSpgqwIICVEGDSAFGFSGMEVETICR 470
Cdd:PRK07525 402 DAIVSTDIGNNCSIANSYLRFEKGRKYLAPGSFGNCGYAFPAIIGAKIACPDRP----VVGFAGDGAWGISMNEVMTAVR 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 471 YNLPIILLVVNNngiYQgfdtdtW----KEMLKFQDATAVVPPmcLLPNSHYEQVMTAFGGKGYFVQTPEELQKSLRQSL 546
Cdd:PRK07525 478 HNWPVTAVVFRN---YQ------WgaekKNQVDFYNNRFVGTE--LDNNVSYAGIAEAMGAEGVVVDTQEELGPALKRAI 546
|
570
....*....|....*
gi 93004078 547 ADTT--KPSLINIMI 559
Cdd:PRK07525 547 DAQNegKTTVIEIMC 561
|
|
| PRK06466 |
PRK06466 |
acetolactate synthase 3 large subunit; |
12-561 |
4.39e-53 |
|
acetolactate synthase 3 large subunit;
Pssm-ID: 180578 [Multi-domain] Cd Length: 574 Bit Score: 190.34 E-value: 4.39e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 12 EQVSGAKVIAQALKTQDVEYIFGIVGIPVTEIAIAA-QQLGIKYIGMRNEQAACYAASAIGYLTSRPGVCLVVSGPGLIH 90
Cdd:PRK06466 2 ELLSGAEMLVRALRDEGVEYIYGYPGGAVLHIYDALfKQDKVEHILVRHEQAATHMADGYARATGKTGVVLVTSGPGATN 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 91 ALGGMANANMNCWPLLVIGGSSERNQETMGAFQEFPQVEACRLYTKFSARPSSIEAIPFVIEKAVRSSIYGRPGACYVDI 170
Cdd:PRK06466 82 AITGIATAYMDSIPMVVLSGQVPSTLIGEDAFQETDMVGISRPIVKHSFMVKHASEIPEIIKKAFYIAQSGRPGPVVVDI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 171 PADFVNLQVNVNSI---KYMERCMSPPiSMAETSAVCTAASVIRNAKQPLLIIGKGAAYAHAEESIKKLVEQYKLPFLPT 247
Cdd:PRK06466 162 PKDMTNPAEKFEYEypkKVKLRSYSPA-VRGHSGQIRKAVEMLLAAKRPVIYSGGGVVLGNASALLTELAHLLNLPVTNT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 248 PMGKGVVPDNHPYCVGA-------ARSRALQFADVIVLFGARLNWILHFGlPPRYQPDVKFIQVDICAEELGNNVKPAVT 320
Cdd:PRK06466 241 LMGLGGFPGTDRQFLGMlgmhgtyEANMAMHHADVILAVGARFDDRVTNG-PAKFCPNAKIIHIDIDPASISKTIKADIP 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 321 LLGNIHAVTKQLLE---ELDKTPWQyPPESKWWKTLREKMKSNEAASKELASKKSL-PMNYYTVFYHVQEQlprDCFVVS 396
Cdd:PRK06466 320 IVGPVESVLTEMLAilkEIGEKPDK-EALAAWWKQIDEWRGRHGLFPYDKGDGGIIkPQQVVETLYEVTNG---DAYVTS 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 397 egantmDIGRTVL---QNYL---PRHRLDAGTFGTMGVGLGFAIAAAVVAKDRSpgqwIICVEGDSAFGFSGMEVETICR 470
Cdd:PRK06466 396 ------DVGQHQMfaaQYYKfnkPNRWINSGGLGTMGFGLPAAMGVKLAFPDQD----VACVTGEGSIQMNIQELSTCLQ 465
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 471 YNLPIILLVVNNNGIyqGFdTDTWKEMLkfQDATAVVPPMCLLPNshYEQVMTAFGGKGYFVQTPEELQKSLRQSLADTT 550
Cdd:PRK06466 466 YGLPVKIINLNNGAL--GM-VRQWQDMQ--YEGRHSHSYMESLPD--FVKLAEAYGHVGIRITDLKDLKPKLEEAFAMKD 538
|
570
....*....|.
gi 93004078 551 KPSLINIMIEP 561
Cdd:PRK06466 539 RLVFIDIYVDR 549
|
|
| PRK06112 |
PRK06112 |
acetolactate synthase catalytic subunit; Validated |
2-563 |
6.09e-53 |
|
acetolactate synthase catalytic subunit; Validated
Pssm-ID: 235700 [Multi-domain] Cd Length: 578 Bit Score: 189.97 E-value: 6.09e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 2 PDSNFAERSEEQVsgAKVIAQALKTQDVEYIFGiVGIPvTEIAIAAQQLGIKYIGMRNEQAACYAASAIGYLTSRPGVCL 81
Cdd:PRK06112 4 PLSAPGFTLNGTV--AHAIARALKRHGVEQIFG-QSLP-SALFLAAEAIGIRQIAYRTENAGGAMADGYARVSGKVAVVT 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 82 VVSGPGLIHALGGMANANMNCWPLLVIGGSSERNQETMGAFQEFPQVEACRLYTKFSARPSSIEAIPFVIEKAVRSSIYG 161
Cdd:PRK06112 80 AQNGPAATLLVAPLAEALKASVPIVALVQDVNRDQTDRNAFQELDHIALFQSCTKWVRRVTVAERIDDYVDQAFTAATSG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 162 RPGACYVDIPADFVNlqvnvnsikymERCMSP-----------PI--SMAETSAVCTAASVIRNAKQPLLIIGKGAAYAH 228
Cdd:PRK06112 160 RPGPVVLLLPADLLT-----------AAAAAPaaprsnslghfPLdrTVPAPQRLAEAASLLAQAQRPVVVAGGGVHISG 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 229 AEESIKKLVEQYKLPFLPTPMGKGVVPDNHPYCVG------AARSRALQF------ADVIVLFGARLN------WILhfg 290
Cdd:PRK06112 229 ASAALAALQSLAGLPVATTNMGKGAVDETHPLSLGvvgslmGPRSPGRHLrdlvreADVVLLVGTRTNqngtdsWSL--- 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 291 lpprYQPDVKFIQVDICAEELGNNVKpAVTLLGNIHAVTKQLLEELDKT--PWQYPPESKWWKTLREKMKSNEAASKELA 368
Cdd:PRK06112 306 ----YPEQAQYIHIDVDGEEVGRNYE-ALRLVGDARLTLAALTDALRGRdlAARAGRRAALEPAIAAGREAHREDSAPVA 380
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 369 SKKSLPMNYYTVFYHVQEQLPRDCFVVSEGA-NTMDIgrtvlQNYLPRHRldAGT-FGT-MGV-GLGFAIAAAVVAKDRS 444
Cdd:PRK06112 381 LSDASPIRPERIMAELQAVLTGDTIVVADASySSIWV-----ANFLTARR--AGMrFLTpRGLaGLGWGVPMAIGAKVAR 453
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 445 PGQWIICVEGDSAFGFSGMEVETICRYNLPIILLVVnNNGIYqGFDTDTwkEMLKFQDATAVVppmcllpnsHYEQV--- 521
Cdd:PRK06112 454 PGAPVICLVGDGGFAHVWAELETARRMGVPVTIVVL-NNGIL-GFQKHA--ETVKFGTHTDAC---------HFAAVdha 520
|
570 580 590 600
....*....|....*....|....*....|....*....|....
gi 93004078 522 --MTAFGGKGYFVQTPEELQKSLRQSLADTTkPSLINIMIEPQA 563
Cdd:PRK06112 521 aiARACGCDGVRVEDPAELAQALAAAMAAPG-PTLIEVITDPSA 563
|
|
| PRK07524 |
PRK07524 |
5-guanidino-2-oxopentanoate decarboxylase; |
17-557 |
3.10e-52 |
|
5-guanidino-2-oxopentanoate decarboxylase;
Pssm-ID: 236041 [Multi-domain] Cd Length: 535 Bit Score: 187.10 E-value: 3.10e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 17 AKVIAQALKTQDVEYIFGIVGIPVTEI--AIAAQqlGIKYIGMRNEQAACYAASaiGY--LTSRPGVCLVVSGPGLIHAL 92
Cdd:PRK07524 5 GEALVRLLEAYGVETVFGIPGVHTVELyrGLAGS--GIRHVTPRHEQGAGFMAD--GYarVSGKPGVCFIITGPGMTNIA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 93 GGMANANMNCWPLLVIGGSSERNQ--ETMGAFQEFP-QVEACRLYTKFSARPSSIEAIPFVIEKAVRSSIYGRPGACYVD 169
Cdd:PRK07524 81 TAMGQAYADSIPMLVISSVNRRASlgKGRGKLHELPdQRAMVAGVAAFSHTLMSAEDLPEVLARAFAVFDSARPRPVHIE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 170 IPADFVNLQVNVNSIKYMERCMSPPismAETSAVCTAASVIRNAKQPLLIIGKGAayAHAEESIKKLVEQYKLPFLPTPM 249
Cdd:PRK07524 161 IPLDVLAAPADHLLPAPPTRPARPG---PAPAALAQAAERLAAARRPLILAGGGA--LAAAAALRALAERLDAPVALTIN 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 250 GKGVVPDNHPYCVGAARS----RAL-QFADVIVLFGARLN-------WILHFGLPPRyqpdvkFIQVDICAEELGNNVKP 317
Cdd:PRK07524 236 AKGLLPAGHPLLLGASQSlpavRALiAEADVVLAVGTELGetdydvyFDGGFPLPGE------LIRIDIDPDQLARNYPP 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 318 AVTLLGNIHAVTKQLLEELdktpwQYPPESKWWKTLREkmksnEAASKELASKKSLPMNYYTVFYH-VQEQLPRDCFV-- 394
Cdd:PRK07524 310 ALALVGDARAALEALLARL-----PGQAAAADWGAARV-----AALRQALRAEWDPLTAAQVALLDtILAALPDAIFVgd 379
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 395 ----VSEGANTMDIGRtvlqnylPRHRLDAGT-FGTMGVGLGFAIAAAVVAKDRsPGqwiICVEGDSAFGFSGMEVETIC 469
Cdd:PRK07524 380 stqpVYAGNLYFDADA-------PRRWFNASTgYGTLGYGLPAAIGAALGAPER-PV---VCLVGDGGLQFTLPELASAV 448
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 470 RYNLPIILLVVNNNGiyqgfdtdtWKEMLKFQDATAVVPPMCLLPNSHYEQVMTAFGGKGYFVQTPEELQKSLRqSLADT 549
Cdd:PRK07524 449 EADLPLIVLLWNNDG---------YGEIRRYMVARDIEPVGVDPYTPDFIALARAFGCAAERVADLEQLQAALR-AAFAR 518
|
....*...
gi 93004078 550 TKPSLINI 557
Cdd:PRK07524 519 PGPTLIEV 526
|
|
| sulphoacet_xsc |
TIGR03457 |
sulfoacetaldehyde acetyltransferase; Members of this protein family are sulfoacetaldehyde ... |
22-559 |
1.74e-51 |
|
sulfoacetaldehyde acetyltransferase; Members of this protein family are sulfoacetaldehyde acetyltransferase, an enzyme of taurine utilization. Taurine, or 2-aminoethanesulfonate, can be used by bacteria as a source of carbon, nitrogen, and sulfur. [Central intermediary metabolism, Other]
Pssm-ID: 132497 [Multi-domain] Cd Length: 579 Bit Score: 185.84 E-value: 1.74e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 22 QALKTQDVEYIFGIVG---IPVTEIAIAAqqlGIKYIGMRNEQAACYAASAIGYLTSRPGVCLVVSGPGLIHALGGMANA 98
Cdd:TIGR03457 10 EVLVANGVTHAFGIMGsafMDAMDLFPPA---GIRFIPVVHEQGAGHMADGFARVTGRMSMVIGQNGPGVTNCVTAIAAA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 99 NMNCWPLLVIGGSSERNQETMGAFQEFPQVEACRLYTKFSARPSSIEAIPFVIEKAVRSSIYGRpGACYVDIPADFV--N 176
Cdd:TIGR03457 87 YWAHTPVVIVTPEAGTKTIGLGGFQEADQLPMFQEFTKYQGHVRHPSRMAEVLNRCFERAWREM-GPAQLNIPRDYFygE 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 177 LQVNVNSIKYMERCMSPPISMAEtsavctAASVIRNAKQPLLIIGKGAAYAHAEESIKKLVEQYKLPFLPTPMGKGVVPD 256
Cdd:TIGR03457 166 IDVEIPRPVRLDRGAGGATSLAQ------AARLLAEAKFPVIISGGGVVMGDAVEECKALAERLGAPVVNSYLHNDSFPA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 257 NHPYCVG-------AARSRALQFADVIVLFGARLNwilHFGLPPRYQPD-----VKFIQVDICAEELGNNVKPAVTLLGN 324
Cdd:TIGR03457 240 SHPLWVGplgyqgsKAAMKLISDADVVLALGTRLG---PFGTLPQYGIDywpknAKIIQVDANAKMIGLVKKVTVGICGD 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 325 IHAVTKQLLEELDKTPWQYPPESK----------WWKTLREKMKSNEAASKELASKKSL----PMNYYTVFYHVQEQLPR 390
Cdd:TIGR03457 317 AKAAAAEILQRLAGKAGDANRAERkakiqaersaWEQELSEMTHERDPFSLDMIVEQRQeegnWLHPRQVLRELEKAMPE 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 391 DCFVVSEGANTMDIGRTVLQNYLPRHRLDAGTFGTMGVGLGFAIAAAVVAKDRSpgqwIICVEGDSAFGFSGMEVETICR 470
Cdd:TIGR03457 397 DAIVSTDIGNINSVANSYLRFEKPRKFLAPMSFGNCGYAFPTIIGAKIAAPDRP----VVAYAGDGAWGMSMNEIMTAVR 472
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 471 YNLPIILLVVNNngiYQgfdtdtW----KEMLKFQDATAVVPPmcLLPNSHYEQVMTAFGGKGYFVQTPEELQKSLRQSL 546
Cdd:TIGR03457 473 HDIPVTAVVFRN---RQ------WgaekKNQVDFYNNRFVGTE--LESELSFAGIADAMGAKGVVVDKPEDVGPALKKAI 541
|
570
....*....|....*
gi 93004078 547 ADTT--KPSLINIMI 559
Cdd:TIGR03457 542 AAQAegKTTVIEIVC 556
|
|
| PRK08199 |
PRK08199 |
thiamine pyrophosphate protein; Validated |
16-563 |
1.29e-49 |
|
thiamine pyrophosphate protein; Validated
Pssm-ID: 181285 [Multi-domain] Cd Length: 557 Bit Score: 180.46 E-value: 1.29e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 16 GAKVIAQALKTQDVEYIFGIVG---IPVTEiAIAAQQlGIKYIGMRNEQAACYAASAIGYLTSRPGVCLVVSGPGLIHAL 92
Cdd:PRK08199 10 GGQILVDALRANGVERVFCVPGesyLAVLD-ALHDET-DIRVIVCRQEGGAAMMAEAYGKLTGRPGICFVTRGPGATNAS 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 93 GGMANANMNCWPLLVIGGSSERNQETMGAFQEFPQVEACRLYTKFSARPSSIEAIPFVIEKAVRSSIYGRPGACYVDIPA 172
Cdd:PRK08199 88 IGVHTAFQDSTPMILFVGQVARDFREREAFQEIDYRRMFGPMAKWVAEIDDAARIPELVSRAFHVATSGRPGPVVLALPE 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 173 DFVNLQVNVNSIKYMERCMSPPiSMAETSAVctaASVIRNAKQPLLIIGKGAAYAHAEESIKKLVEQYKLPFLPTPMGKG 252
Cdd:PRK08199 168 DVLSETAEVPDAPPYRRVAAAP-GAADLARL---AELLARAERPLVILGGSGWTEAAVADLRAFAERWGLPVACAFRRQD 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 253 VVPDNHPYCVG----------AARSRAlqfADVIVLFGARLNWILHFGL----PPRyqPDVKFIQVDICAEELGNNVKPA 318
Cdd:PRK08199 244 LFDNRHPNYAGdlglginpalAARIRE---ADLVLAVGTRLGEVTTQGYtlldIPV--PRQTLVHVHPDAEELGRVYRPD 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 319 VTllgnIHAVTKQLLEELDKtpWQYPPESKWWKTLREKMKSNEAASKELASKKSLPMNyyTVFYHVQEQLPRDcFVVSEG 398
Cdd:PRK08199 319 LA----IVADPAAFAAALAA--LEPPASPAWAEWTAAAHADYLAWSAPLPGPGAVQLG--EVMAWLRERLPAD-AIITNG 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 399 AntmdiGR--TVLQNYLPRHRLD---AGTFGTMGVGLgfaiAAAVVAKDRSPGQWIICVEGDSAFGFSGMEVETICRYNL 473
Cdd:PRK08199 390 A-----GNyaTWLHRFFRFRRYRtqlAPTSGSMGYGL----PAAIAAKLLFPERTVVAFAGDGCFLMNGQELATAVQYGL 460
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 474 PIILLVVnNNGIYQGFDTDTWKEMLKFQDATAvvppmclLPNSHYEQVMTAFGGKGYFVQTPEELQKSLRQSLAdTTKPS 553
Cdd:PRK08199 461 PIIVIVV-NNGMYGTIRMHQEREYPGRVSGTD-------LTNPDFAALARAYGGHGETVERTEDFAPAFERALA-SGKPA 531
|
570
....*....|
gi 93004078 554 LINIMIEPQA 563
Cdd:PRK08199 532 LIEIRIDPEA 541
|
|
| PRK07282 |
PRK07282 |
acetolactate synthase large subunit; |
11-559 |
1.37e-49 |
|
acetolactate synthase large subunit;
Pssm-ID: 180919 [Multi-domain] Cd Length: 566 Bit Score: 180.40 E-value: 1.37e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 11 EEQVSGAKVIAQALKTQDVEYIFGIVGIPVTEI--AIAAQQlGIKYIGMRNEQAACYAASAIGYLTSRPGVCLVVSGPGL 88
Cdd:PRK07282 7 ESPKSGSDLVLETLRDLGVDTIFGYPGGAVLPLydAIYNFE-GIRHILARHEQGALHEAEGYAKSTGKLGVAVVTSGPGA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 89 IHALGGMANANMNCWPLLVIGGSSERNQETMGAFQEFPQVEACRLYTKFSARPSSIEAIPFVIEKAVRSSIYGRPGACYV 168
Cdd:PRK07282 86 TNAITGIADAMSDSVPLLVFTGQVARAGIGKDAFQEADIVGITMPITKYNYQIRETADIPRIITEAVHIATTGRPGPVVI 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 169 DIPADFVNLQVN-VNSIKYMERCMSPPISmAETSAVCTAASVIRNAKQPLLIIGKGAAYAHAEESIKKLVEQYKLPFLPT 247
Cdd:PRK07282 166 DLPKDVSALETDfIYDPEVNLPSYQPTLE-PNDMQIKKILKQLSKAKKPVILAGGGINYAEAATELNAFAERYQIPVVTT 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 248 PMGKGVVPDNHPYCVGA-------ARSRALQFADVIVLFGARLNWILhFGLPPRYQPDVKFIQVDICAEELGNNVKPAVT 320
Cdd:PRK07282 245 LLGQGTIATSHPLFLGMggmhgsyAANIAMTEADFMINIGSRFDDRL-TGNPKTFAKNAKVAHIDIDPAEIGKIIKTDIP 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 321 LLGNIHAVTKQLLEElDKTPWQYppeSKWWKTL---REKMKSNEAASKELASKKSLPMnyytvfyhVQEQLPRDCFVVSe 397
Cdd:PRK07282 324 VVGDAKKALQMLLAE-PTVHNNT---EKWIEKVtkdKNRVRSYDKKERVVQPQAVIER--------IGELTNGDAIVVT- 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 398 gantmDIGRTVL--QNYLP----RHRLDAGTFGTMgvglGFAIAAAVVAKDRSPGQWIICVEGDSAFGFSGMEVETICRY 471
Cdd:PRK07282 391 -----DVGQHQMwaAQYYPyqneRQLVTSGGLGTM----GFGIPAAIGAKIANPDKEVILFVGDGGFQMTNQELAILNIY 461
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 472 NLPIILLVVNNNGIyqGFdTDTWKEmlKFQDATAVVPPMCLLPNshYEQVMTAFGGKGYFVQTPEELQKSLRQSLADttK 551
Cdd:PRK07282 462 KVPIKVVMLNNHSL--GM-VRQWQE--SFYEGRTSESVFDTLPD--FQLMAQAYGIKHYKFDNPETLAQDLEVITED--V 532
|
....*...
gi 93004078 552 PSLINIMI 559
Cdd:PRK07282 533 PMLIEVDI 540
|
|
| PRK08155 |
PRK08155 |
acetolactate synthase large subunit; |
12-483 |
2.51e-49 |
|
acetolactate synthase large subunit;
Pssm-ID: 181257 [Multi-domain] Cd Length: 564 Bit Score: 179.52 E-value: 2.51e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 12 EQVSGAKVIAQALKTQDVEYIFGIVGIPVTEIAIA-AQQLGIKYIGMRNEQAACYAASAIGYLTSRPGVCLVVSGPGLIH 90
Cdd:PRK08155 11 KRFTGAELIVRLLERQGIRIVTGIPGGAILPLYDAlSQSTQIRHILARHEQGAGFIAQGMARTTGKPAVCMACSGPGATN 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 91 ALGGMANANMNCWPLLVIGGSSERNQETMGAFQEFPQVEACRLYTKFSARPSSIEAIPFVIEKAVRSSIYGRPGACYVDI 170
Cdd:PRK08155 91 LVTAIADARLDSIPLVCITGQVPASMIGTDAFQEVDTYGISIPITKHNYLVRDIEELPQVISDAFRIAQSGRPGPVWIDI 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 171 PADFVNLQVNVNSIKYMERCMSPPisMAETSAVCTAASVIRNAKQPLLIIGKGAAYAHAEESIKKLVEQYKLPFLPTPMG 250
Cdd:PRK08155 171 PKDVQTAVIELEALPAPAEKDAAP--AFDEESIRDAAAMINAAKRPVLYLGGGVINSGAPARARELAEKAQLPTTMTLMA 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 251 KGVVPDNHPYCVG-----AARSR--ALQFADVIVLFGARlnwilhF-----GLPPRYQPDVKFIQVDICAEELGNNVKPA 318
Cdd:PRK08155 249 LGMLPKAHPLSLGmlgmhGARSTnyILQEADLLIVLGAR------FddraiGKTEQFCPNAKIIHVDIDRAELGKIKQPH 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 319 VTLLGNIHAVTKQLLeeldktPWQYPPESKWWKTLREKMKSNEAASKELASKkslPMNYYTVFYHVQEQLPRDCFVvseg 398
Cdd:PRK08155 323 VAIQADVDDVLAQLL------PLVEAQPRAEWHQLVADLQREFPCPIPKADD---PLSHYGLINAVAACVDDNAII---- 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 399 anTMDIGRT---VLQNY---LPRHRLDAGTFGTMGVGLGFAIAAAVVAKDRSpgqwIICVEGDSAFGFSGMEVETICRYN 472
Cdd:PRK08155 390 --TTDVGQHqmwTAQAYplnRPRQWLTSGGLGTMGFGLPAAIGAALANPERK----VLCFSGDGSLMMNIQEMATAAENQ 463
|
490
....*....|.
gi 93004078 473 LPIILLVVNNN 483
Cdd:PRK08155 464 LDVKIILMNNE 474
|
|
| TPP_enzyme_N |
pfam02776 |
Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; |
16-180 |
2.51e-47 |
|
Thiamine pyrophosphate enzyme, N-terminal TPP binding domain;
Pssm-ID: 460690 [Multi-domain] Cd Length: 169 Bit Score: 163.17 E-value: 2.51e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 16 GAKVIAQALKTQDVEYIFGIVGIPVTEIAIAAQ-QLGIKYIGMRNEQAACYAASAIGYLTSRPGVCLVVSGPGLIHALGG 94
Cdd:pfam02776 1 GAEALADVLKALGVDTVFGVPGGHILPLLDALAkSPGIRYVLTRHEQGAAFAADGYARATGKPGVVLVTSGPGATNALTG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 95 MANANMNCWPLLVIGGSSERNQETMGAFQ-EFPQVEACRLYTKFSARPSSIEAIPFVIEKAVRSSIYGRPGACYVDIPAD 173
Cdd:pfam02776 81 LANAYVDSVPLLVISGQRPRSLVGRGALQqELDQLALFRPVTKWAVRVTSADEIPEVLRRAFRAALSGRPGPVYLEIPLD 160
|
....*..
gi 93004078 174 FVNLQVN 180
Cdd:pfam02776 161 VLLEEVD 167
|
|
| PRK07789 |
PRK07789 |
acetolactate synthase 1 catalytic subunit; Validated |
12-482 |
7.24e-47 |
|
acetolactate synthase 1 catalytic subunit; Validated
Pssm-ID: 236098 [Multi-domain] Cd Length: 612 Bit Score: 173.63 E-value: 7.24e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 12 EQVSGAKVIAQALKTQDVEYIFGIVG---IPVTEIAIAAQQLgiKYIGMRNEQAACYAASAIGYLTSRPGVCLVVSGPG- 87
Cdd:PRK07789 29 ERMTGAQAVVRSLEELGVDVVFGIPGgaiLPVYDPLFDSTKV--RHVLVRHEQGAGHAAEGYAQATGRVGVCMATSGPGa 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 88 --LIHALggmANANMNCWPLLVIGGSSERNQETMGAFQEFPQVEACRLYTKFSARPSSIEAIPFVIEKAVRSSIYGRPGA 165
Cdd:PRK07789 107 tnLVTPI---ADANMDSVPVVAITGQVGRGLIGTDAFQEADIVGITMPITKHNFLVTDADDIPRVIAEAFHIASTGRPGP 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 166 CYVDIPADFVNLQVNVNSIKYMERCMSPPISMAETSAVCTAASVIRNAKQPLLIIGKGAAYAHAEESIKKLVEQYKLPFL 245
Cdd:PRK07789 184 VLVDIPKDALQAQTTFSWPPRMDLPGYRPVTKPHGKQIREAAKLIAAARRPVLYVGGGVIRAEASAELRELAELTGIPVV 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 246 PTPMGKGVVPDNHPYCVG-------AARSRALQFADVIVLFGARlnwilhF-----GLPPRYQPDVKFIQVDICAEELGN 313
Cdd:PRK07789 264 TTLMARGAFPDSHPQHLGmpgmhgtVAAVAALQRSDLLIALGAR------FddrvtGKLDSFAPDAKVIHADIDPAEIGK 337
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 314 NVKPAVTLLGNIHAVTKQLLEEL--DKTPWQYPPESKWWKTLReKMKSNEAASKELASKKSL-PMnyytvfyHVQEQL-- 388
Cdd:PRK07789 338 NRHADVPIVGDVKEVIAELIAALraEHAAGGKPDLTAWWAYLD-GWRETYPLGYDEPSDGSLaPQ-------YVIERLge 409
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 389 ---PRDCFVVSEGANTMDIGRTVlqNY-LPRHRLDAGTFGTMgvglGFAIAAAVVAKDRSPGQWIICVEGDSAFGFSGME 464
Cdd:PRK07789 410 iagPDAIYVAGVGQHQMWAAQFI--DYeKPRTWLNSGGLGTM----GYAVPAAMGAKVGRPDKEVWAIDGDGCFQMTNQE 483
|
490
....*....|....*...
gi 93004078 465 VETICRYNLPIILLVVNN 482
Cdd:PRK07789 484 LATCAIEGIPIKVALINN 501
|
|
| PRK08978 |
PRK08978 |
acetolactate synthase 2 catalytic subunit; Reviewed |
16-482 |
8.28e-47 |
|
acetolactate synthase 2 catalytic subunit; Reviewed
Pssm-ID: 181601 [Multi-domain] Cd Length: 548 Bit Score: 172.37 E-value: 8.28e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 16 GAKVIAQALKTQDVEYIFGIVGIPVTEIAIAAQQLGIKYIGMRNEQAAcyAASAIGY--LTSRPGVCLVVSGPGLIHALG 93
Cdd:PRK08978 3 GAQWVVHALRAQGVDTVFGYPGGAIMPVYDALYDGGVEHLLCRHEQGA--AMAAIGYarATGKVGVCIATSGPGATNLIT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 94 GMANANMNCWPLLVIGGssERNQETMG--AFQE---FPQVEACrlyTKFSARPSSIEAIPFVIEKAVRSSIYGRPGACYV 168
Cdd:PRK08978 81 GLADALLDSVPVVAITG--QVSSPLIGtdAFQEidvLGLSLAC---TKHSFLVQSLEELPEIMAEAFEIASSGRPGPVLV 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 169 DIPADfvnLQVNVNSIK-YMERCMSPPisMAETSAVCTAASVIRNAKQPLLIIGKGAAYAHAEESIKKLVEQYKLPFLPT 247
Cdd:PRK08978 156 DIPKD---IQLAEGELEpHLTTVENEP--AFPAAELEQARALLAQAKKPVLYVGGGVGMAGAVPALREFLAATGMPAVAT 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 248 PMGKGVVPDNHPYCVG-------AARSRALQFADVIVLFGARlnwilhF-----GLPPRYQPDVKFIQVDICAEELGNNV 315
Cdd:PRK08978 231 LKGLGAVEADHPYYLGmlgmhgtKAANLAVQECDLLIAVGAR------FddrvtGKLNTFAPHAKVIHLDIDPAEINKLR 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 316 KPAVTLLGNIHAVTKQLLEELDKTPWQyppesKWWKTLREKMKSNEAASKELASKKSLpmnyytvFYHVQEQLPRDCFVv 395
Cdd:PRK08978 305 QAHVALQGDLNALLPALQQPLNIDAWR-----QHCAQLRAEHAWRYDHPGEAIYAPAL-------LKQLSDRKPADTVV- 371
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 396 seganTMDIGRT---VLQNYL---PRHRLDAGTFGTMGVGLGFAIAAAVVakdrSPGQWIICVEGDSAFGFSGMEVETIC 469
Cdd:PRK08978 372 -----TTDVGQHqmwVAQHMRftrPENFITSSGLGTMGFGLPAAIGAQVA----RPDDTVICVSGDGSFMMNVQELGTIK 442
|
490
....*....|...
gi 93004078 470 RYNLPIILLVVNN 482
Cdd:PRK08978 443 RKQLPVKIVLLDN 455
|
|
| PRK06965 |
PRK06965 |
acetolactate synthase 3 catalytic subunit; Validated |
10-550 |
5.50e-46 |
|
acetolactate synthase 3 catalytic subunit; Validated
Pssm-ID: 180780 [Multi-domain] Cd Length: 587 Bit Score: 170.75 E-value: 5.50e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 10 SEEQVSGAKVIAQALKTQDVEYIFGIVGIPVTEIAIAA-QQLGIKYIGMRNEQAACYAASAIGYLTSRPGVCLVVSGPGL 88
Cdd:PRK06965 17 PAADSIGAEILMKALAAEGVEFIWGYPGGAVLYIYDELyKQDKIQHVLVRHEQAAVHAADGYARATGKVGVALVTSGPGV 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 89 IHALGGMANANMNCWPLLVIGGSSERNQETMGAFQEFPQVEACRLYTKFSARPSSIEAIPFVIEKAVRSSIYGRPGACYV 168
Cdd:PRK06965 97 TNAVTGIATAYMDSIPMVVISGQVPTAAIGQDAFQECDTVGITRPIVKHNFLVKDVRDLAETVKKAFYIARTGRPGPVVV 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 169 DIPADfvnlqVNVNSIKY-----MERCMSPPISMAETSAVCTAASVIRNAKQPLLIIGKGAAYAHAEESIKKLVEQYKLP 243
Cdd:PRK06965 177 DIPKD-----VSKTPCEYeypksVEMRSYNPVTKGHSGQIRKAVSLLLSAKRPYIYTGGGVILANASRELRQLADLLGYP 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 244 FLPTPMGKGVVPDNHPYCVGA-------ARSRALQFADVIVLFGARLNWIL-----HFGLPPRyqpdvKFIQVDICAEEL 311
Cdd:PRK06965 252 VTNTLMGLGAYPASDKKFLGMlgmhgtyEANMAMQHCDVLIAIGARFDDRVignpaHFASRPR-----KIIHIDIDPSSI 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 312 GNNVKPAVTLLGNIHAVTKQLLEELDKTPWQYPPE--SKWWKTLrEKMKSNEAASKELASKKSLPMnyytvfyHVQEQL- 388
Cdd:PRK06965 327 SKRVKVDIPIVGDVKEVLKELIEQLQTAEHGPDADalAQWWKQI-EGWRSRDCLKYDRESEIIKPQ-------YVVEKLw 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 389 ---PRDCFVVSegantmDIGRTVL---QNYL---PRHRLDAGTFGTMGVGLGFAIAaavvAKDRSPGQWIICVEGDSAFG 459
Cdd:PRK06965 399 eltDGDAFVCS------DVGQHQMwaaQFYRfnePRRWINSGGLGTMGVGLPYAMG----IKMAHPDDDVVCITGEGSIQ 468
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 460 FSGMEVETICRYNLPIILLVVNNNgiYQGFdTDTWKEM-------LKFQDAtavvppmclLPNshYEQVMTAFGGKGYFV 532
Cdd:PRK06965 469 MCIQELSTCLQYDTPVKIISLNNR--YLGM-VRQWQEIeyskrysHSYMDA---------LPD--FVKLAEAYGHVGMRI 534
|
570 580
....*....|....*....|
gi 93004078 533 QTPEELQKSLRQS--LADTT 550
Cdd:PRK06965 535 EKTSDVEPALREAlrLKDRT 554
|
|
| PRK06457 |
PRK06457 |
pyruvate dehydrogenase; Provisional |
15-564 |
1.13e-45 |
|
pyruvate dehydrogenase; Provisional
Pssm-ID: 180570 [Multi-domain] Cd Length: 549 Bit Score: 169.24 E-value: 1.13e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 15 SGAKVIAQALKTQDVEYIFGIVGIPVTEIAIAAQQLGIKYIGMRNEQAACYAASAIGYLTSRPGVCLVVSGPGLIHALGG 94
Cdd:PRK06457 3 SVAEVIIRVLEDNGIQRIYGIPGDSIDPLVDAIRKSKVKYVQVRHEEGAALAASVEAKITGKPSACMGTSGPGSIHLLNG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 95 MANANMNCWPLLVIGGSSERNQETMGAFQEfpqVEACRLY---TKFSARPSSIEAIPFVIEKAVRSSIYGRpGACYVDIP 171
Cdd:PRK06457 83 LYDAKMDHAPVIALTGQVESDMIGHDYFQE---VNLTKLFddvAVFNQILINPENAEYIIRRAIREAISKR-GVAHINLP 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 172 ADFVNLQVNVNSIKYMERC---MSPPISMAEtsavctaaSVIRNAKQPLLIIGKGAAyAHAEEsIKKLVEQYKLPFLPTP 248
Cdd:PRK06457 159 VDILRKSSEYKGSKNTEVGkvkYSIDFSRAK--------ELIKESEKPVLLIGGGTR-GLGKE-INRFAEKIGAPIIYTL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 249 MGKGVVPDNHPYCVGA-------ARSRALQFADVIVLFGARLNWILHFglppryQPDVKFIQVDICAEELGNNVKPAVTL 321
Cdd:PRK06457 229 NGKGILPDLDPKVMGGigllgtkPSIEAMDKADLLIMLGTSFPYVNFL------NKSAKVIQVDIDNSNIGKRLDVDLSY 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 322 LGNihaVTKQLLEELDKTPWQYPPESKwwktlREKMKSNEAASKeLASKKSLPMNYYTVFYHVQEQLPRDCFVVSEGAN- 400
Cdd:PRK06457 303 PIP---VAEFLNIDIEEKSDKFYEELK-----GKKEDWLDSISK-QENSLDKPMKPQRVAYIVSQKCKKDAVIVTDTGNv 373
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 401 TMdigrtvlqnYLPRHRLDAG--TF------GTMGVGLGFAIAAAVVAKDRspgQWIICVEGDSAFGFSGMEVETICRYN 472
Cdd:PRK06457 374 TM---------WTARHFRASGeqTFifsawlGSMGIGVPGSVGASFAVENK---RQVISFVGDGGFTMTMMELITAKKYD 441
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 473 LPIILLVVNNNGIyqgfdtdtwkEMLKFQDATAVVPPMCL-LPNSHYEQVMTAFGGKGYFVQTPEELQKSLRQSLaDTTK 551
Cdd:PRK06457 442 LPVKIIIYNNSKL----------GMIKFEQEVMGYPEWGVdLYNPDFTKIAESIGFKGFRLEEPKEAEEIIEEFL-NTKG 510
|
570
....*....|...
gi 93004078 552 PSLINIMIEPQAT 564
Cdd:PRK06457 511 PAVLDAIVDPNER 523
|
|
| PRK07710 |
PRK07710 |
acetolactate synthase large subunit; |
9-561 |
2.90e-45 |
|
acetolactate synthase large subunit;
Pssm-ID: 236076 [Multi-domain] Cd Length: 571 Bit Score: 168.40 E-value: 2.90e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 9 RSEEQVSGAKVIAQALKTQDVEYIFGIVGIPVTEIAIAAQQLGIKYIGMRNEQAACYAASAIGYLTSRPGVCLVVSGPGL 88
Cdd:PRK07710 11 TEEKLMTGAQMLIEALEKEGVEVIFGYPGGAVLPLYDALYDCGIPHILTRHEQGAIHAAEGYARISGKPGVVIATSGPGA 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 89 IHALGGMANANMNCWPLLVIGGSSERNQETMGAFQEFPQVEACRLYTKFSARPSSIEAIPFVIEKAVRSSIYGRPGACYV 168
Cdd:PRK07710 91 TNVVTGLADAMIDSLPLVVFTGQVATSVIGSDAFQEADIMGITMPVTKHNYQVRKASDLPRIIKEAFHIATTGRPGPVLI 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 169 DIPADFVNLQVNVNSIKYMERCMSPPISMAETSAVCTAASVIRNAKQPLLIIGKGAAYAHAEESIKKLVEQYKLPFLPTP 248
Cdd:PRK07710 171 DIPKDMVVEEGEFCYDVQMDLPGYQPNYEPNLLQIRKLVQAVSVAKKPVILAGAGVLHAKASKELTSYAEQQEIPVVHTL 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 249 MGKGVVPDNHPYCVGAA-------RSRALQFADVIVLFGARLNWILHFGLpPRYQPDVKFIQVDICAEELGNNVKPAVTL 321
Cdd:PRK07710 251 LGLGGFPADHPLFLGMAgmhgtytANMALYECDLLINIGARFDDRVTGNL-AYFAKEATVAHIDIDPAEIGKNVPTEIPI 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 322 LGNIHAVTKQLLEELDKtpwqyPPESKWWKTLREKMKSNEAASKELASKKSLPMNYYTVFYHvqeqlprdcFVVSEGANT 401
Cdd:PRK07710 330 VADAKQALQVLLQQEGK-----KENHHEWLSLLKNWKEKYPLSYKRNSESIKPQKAIEMLYE---------ITKGEAIVT 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 402 MDIGRTVL--QNYLPRHRLD----AGTFGTMGVGLGFAIAAAVVAKDRSpgqwIICVEGDSAFGFSGMEVETICRYNLPI 475
Cdd:PRK07710 396 TDVGQHQMwaAQYYPFKTPDkwvtSGGLGTMGFGLPAAIGAQLAKPDET----VVAIVGDGGFQMTLQELSVIKELSLPV 471
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 476 ILLVVNNNGIYQgfdTDTWKEMLKFQDATAvvppmCLLPNS-HYEQVMTAFGGKGYFVQTPEELQKSLRQSLAdTTKPSL 554
Cdd:PRK07710 472 KVVILNNEALGM---VRQWQEEFYNQRYSH-----SLLSCQpDFVKLAEAYGIKGVRIDDELEAKEQLQHAIE-LQEPVV 542
|
....*..
gi 93004078 555 INIMIEP 561
Cdd:PRK07710 543 IDCRVLQ 549
|
|
| TPP_enzyme_M |
pfam00205 |
Thiamine pyrophosphate enzyme, central domain; The central domain of TPP enzymes contains a ... |
206-332 |
5.53e-45 |
|
Thiamine pyrophosphate enzyme, central domain; The central domain of TPP enzymes contains a 2-fold Rossman fold.
Pssm-ID: 425523 [Multi-domain] Cd Length: 137 Bit Score: 155.80 E-value: 5.53e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 206 AASVIRNAKQPLLIIGKGAAYAHAEESIKKLVEQYKLPFLPTPMGKGVVPDNHPYCVG-------AARSRALQFADVIVL 278
Cdd:pfam00205 4 AAELLKKAKRPVILAGGGVRRSGASEELRELAEKLGIPVVTTLMGKGAFPEDHPLYLGmlgmhgtPAANEALEEADLVLA 83
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 93004078 279 FGARLNWILHFGLPPRYQPDVKFIQVDICAEELGNNVKPAVTLLGNIHAVTKQL 332
Cdd:pfam00205 84 VGARFDDIRTTGKLPEFAPDAKIIHIDIDPAEIGKNYPVDVPIVGDAKETLEAL 137
|
|
| PLN02470 |
PLN02470 |
acetolactate synthase |
2-482 |
2.05e-44 |
|
acetolactate synthase
Pssm-ID: 215261 [Multi-domain] Cd Length: 585 Bit Score: 166.45 E-value: 2.05e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 2 PDSNFAErsEEQVSGAKVIAQALKTQDVEYIFGIVGIPVTEIAIA-AQQLGIKYIGMRNEQAACYAASAIGYLTSRPGVC 80
Cdd:PLN02470 3 FQSRFAP--DEPRKGADILVEALEREGVDTVFAYPGGASMEIHQAlTRSNCIRNVLCRHEQGEVFAAEGYAKASGKVGVC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 81 LVVSGPGLIHALGGMANANMNCWPLLVIGGSSERNQETMGAFQEFPQVEACRLYTKFSARPSSIEAIPFVIEKAVRSSIY 160
Cdd:PLN02470 81 IATSGPGATNLVTGLADALLDSVPLVAITGQVPRRMIGTDAFQETPIVEVTRSITKHNYLVMDVEDIPRVIREAFFLASS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 161 GRPGACYVDIPADfVNLQVNV----NSIK---YMERCMSPPismaETSAVCTAASVIRNAKQPLLIIGKGAayAHAEESI 233
Cdd:PLN02470 161 GRPGPVLVDIPKD-IQQQLAVpnwnQPMKlpgYLSRLPKPP----EKSQLEQIVRLISESKRPVVYVGGGC--LNSSEEL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 234 KKLVEQYKLPFLPTPMGKGVVPDNHPYCV------GAARSR-ALQFADVIVLFGARLNWILHfGLPPRYQPDVKFIQVDI 306
Cdd:PLN02470 234 REFVELTGIPVASTLMGLGAFPASDELSLqmlgmhGTVYANyAVDSADLLLAFGVRFDDRVT-GKLEAFASRASIVHIDI 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 307 CAEELGNNVKPAVTLLGNIHAVTKQLLEELDKTPWQYPPESKWWKTLREKmksneaaskelasKKSLPMNYYTVF----- 381
Cdd:PLN02470 313 DPAEIGKNKQPHVSVCADVKLALQGLNKLLEERKAKRPDFSAWRAELDEQ-------------KEKFPLSYPTFGdaipp 379
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 382 -YHVQ--EQLPRDCFVVSEGANTMDIGRTVLQNY-LPRHRLDAGTFGTMGVGLGFAIAAAVVakdrSPGQWIICVEGDSA 457
Cdd:PLN02470 380 qYAIQvlDELTDGNAIISTGVGQHQMWAAQWYKYkEPRRWLTSGGLGAMGFGLPAAIGAAAA----NPDAIVVDIDGDGS 455
|
490 500
....*....|....*....|....*
gi 93004078 458 FGFSGMEVETICRYNLPIILLVVNN 482
Cdd:PLN02470 456 FIMNIQELATIHVENLPVKIMVLNN 480
|
|
| PRK09107 |
PRK09107 |
acetolactate synthase 3 catalytic subunit; Validated |
12-560 |
2.36e-41 |
|
acetolactate synthase 3 catalytic subunit; Validated
Pssm-ID: 236380 [Multi-domain] Cd Length: 595 Bit Score: 157.95 E-value: 2.36e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 12 EQVSGAKVIAQALKTQDVEYIFGIVGIPVTEIAIAA-QQLGIKYIGMRNEQAACYAASAIGYLTSRPGVCLVVSGPGLIH 90
Cdd:PRK09107 9 RQMTGAEMVVQALKDQGVEHIFGYPGGAVLPIYDEIfQQDDIQHILVRHEQGAGHAAEGYARSTGKPGVVLVTSGPGATN 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 91 ALGGMANANMNCWPLLVIGGSSERNQETMGAFQEFPQVEACRLYTKFSARPSSIEAIPFVIEKAVRSSIYGRPGACYVDI 170
Cdd:PRK09107 89 AVTPLQDALMDSIPLVCITGQVPTHLIGSDAFQECDTVGITRPCTKHNWLVKDVNDLARVIHEAFHVATSGRPGPVVVDI 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 171 PAD-------FVNLQVNVNSIKYmercmsPPISMAETSAVCTAASVIRNAKQPLLIIGKGA--AYAHAEESIKKLVEQYK 241
Cdd:PRK09107 169 PKDvqfatgtYTPPQKAPVHVSY------QPKVKGDAEAITEAVELLANAKRPVIYSGGGVinSGPEASRLLRELVELTG 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 242 LPFLPTPMGKGVVPDNHPYCVGA-------ARSRALQFADVIVLFGARlnwilhF-----GLPPRYQPDVKFIQVDICAE 309
Cdd:PRK09107 243 FPITSTLMGLGAYPASGKNWLGMlgmhgtyEANMAMHDCDVMLCVGAR------FddritGRLDAFSPNSKKIHIDIDPS 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 310 ELGNNVKPAVTLLGNIHAVTKQLLEELDKTPWQYPPE--SKWWKTLREKMKSNEAASKElasKKSLPMNYYTVfyhvqEQ 387
Cdd:PRK09107 317 SINKNVRVDVPIIGDVGHVLEDMLRLWKARGKKPDKEalADWWGQIARWRARNSLAYTP---SDDVIMPQYAI-----QR 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 388 L-----PRDCFVVSE-GANTMdigrTVLQNY---LPRHRLDAGTFGTMGVGLGFAIAAAVVakdrSPGQWIICVEGDSAF 458
Cdd:PRK09107 389 LyeltkGRDTYITTEvGQHQM----WAAQFFgfeEPNRWMTSGGLGTMGYGLPAALGVQIA----HPDALVIDIAGDASI 460
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 459 GFSGMEVETICRYNLPIILLVVNNNgiYQGFdTDTWKEML-------KFQDAtavvppmclLPNshYEQVMTAFGGKGYF 531
Cdd:PRK09107 461 QMCIQEMSTAVQYNLPVKIFILNNQ--YMGM-VRQWQQLLhgnrlshSYTEA---------MPD--FVKLAEAYGAVGIR 526
|
570 580
....*....|....*....|....*....
gi 93004078 532 VQTPEELQKSLRQSLaDTTKPSLINIMIE 560
Cdd:PRK09107 527 CEKPGDLDDAIQEMI-DVDKPVIFDCRVA 554
|
|
| PRK07064 |
PRK07064 |
thiamine pyrophosphate-binding protein; |
12-484 |
2.50e-35 |
|
thiamine pyrophosphate-binding protein;
Pssm-ID: 180820 [Multi-domain] Cd Length: 544 Bit Score: 139.74 E-value: 2.50e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 12 EQVSGAKVIAQALKTQDVEYIFGIVGIPVTEIAIA-AQQLGIKYIGMRNEQAACYAASAIGYLTSRPGVCLVVSGPGLIH 90
Cdd:PRK07064 1 EKVTVGELIAAFLEQCGVKTAFGVISIHNMPILDAiGRRGKIRFVPARGEAGAVNMADAHARVSGGLGVALTSTGTGAGN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 91 ALGGMANANMNCWPLLVIGGSSERN--QETMGAFQEFP-QVEACRLYTKFSARPSSIEAIPFVIEKAVRSSIYGRPGACY 167
Cdd:PRK07064 81 AAGALVEALTAGTPLLHITGQIETPylDQDLGYIHEAPdQLTMLRAVSKAAFRVRSAETALATIREAVRVALTAPTGPVS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 168 VDIPADfvnlqvnvnsIKYMERCMS-------PPISMAETSAVCTAASVIRNAKQPLLIIGKGAayAHAEESIKKLVEqY 240
Cdd:PRK07064 161 VEIPID----------IQAAEIELPddlapvhVAVPEPDAAAVAELAERLAAARRPLLWLGGGA--RHAGAEVKRLVD-L 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 241 KLPFLPTPMGKGVVPDNHPYCVGA----ARSRAL-QFADVIVLFGARL--NWILHFGLP-PRyqpdvKFIQVDICAEELG 312
Cdd:PRK07064 228 GFGVVTSTQGRGVVPEDHPASLGAfnnsAAVEALyKTCDLLLVVGSRLrgNETLKYSLAlPR-----PLIRVDADAAADG 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 313 NNVKPAVTLLGNIHAVTKQLLEELDKTPWQYPpesKWWKTLREKMKSNEAA-SKELASKKSLPmnyytvfYHVQEQLPRD 391
Cdd:PRK07064 303 RGYPNDLFVHGDAARVLARLADRLEGRLSVDP---AFAADLRAAREAAVADlRKGLGPYAKLV-------DALRAALPRD 372
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 392 CFVVSegantmDI---GRTVLQNYLPRHRLDAGTF---GTMGVGLGFAIAAAVVakdrSPGQWIICVEGDSAFGFSGMEV 465
Cdd:PRK07064 373 GNWVR------DVtisNSTWGNRLLPIFEPRANVHalgGGIGQGLAMAIGAALA----GPGRKTVGLVGDGGLMLNLGEL 442
|
490
....*....|....*....
gi 93004078 466 ETICRYNLPIILLVVNNNG 484
Cdd:PRK07064 443 ATAVQENANMVIVLMNDGG 461
|
|
| PDC1 |
COG3961 |
TPP-dependent 2-oxoacid decarboxylase, includes indolepyruvate decarboxylase [Carbohydrate ... |
20-562 |
1.72e-33 |
|
TPP-dependent 2-oxoacid decarboxylase, includes indolepyruvate decarboxylase [Carbohydrate transport and metabolism, Coenzyme transport and metabolism, General function prediction only]; TPP-dependent 2-oxoacid decarboxylase, includes indolepyruvate decarboxylase is part of the Pathway/BioSystem: Pyruvate oxidation
Pssm-ID: 443161 [Multi-domain] Cd Length: 545 Bit Score: 134.52 E-value: 1.72e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 20 IAQALKTQDVEYIFGIVGIPVTEI--AIAAQQlGIKYIGMRNEQAACYAASaiGYLTSRPGVCLVVS-GPGLIHALGGMA 96
Cdd:COG3961 11 LLDRLAELGIRHIFGVPGDYNLPFldAIEAHP-GIRWVGCCNELNAGYAAD--GYARVNGLGALVTTyGVGELSAINGIA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 97 NANMNCWPLLVIGG---SSERNQETM-------GAFQEFpqveaCRLYTKFSARPSSIEA------IPFVIEKAVRssiY 160
Cdd:COG3961 88 GAYAERVPVVHIVGapgTRAQRRGPLlhhtlgdGDFDHF-----LRMFEEVTVAQAVLTPenaaaeIDRVLAAALR---E 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 161 GRPGacYVDIPADFVNLQVNVNSIKYMercMSPPISMAET--SAVCTAASVIRNAKQPLLIIGKGAAYAHAEESIKKLVE 238
Cdd:COG3961 160 KRPV--YIELPRDVADAPIEPPEAPLP---LPPPASDPAAlaAAVAAAAERLAKAKRPVILAGVEVHRFGLQEELLALAE 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 239 QYKLPFLPTPMGKGVVPDNHPYCVG-----AARSRALQF---ADVIVLFGARLN----WILHFGLPPRyqpdvKFIQVDI 306
Cdd:COG3961 235 KTGIPVATTLLGKSVLDESHPQFIGtyagaASSPEVREYvenADCVLCLGVVFTdtntGGFTAQLDPE-----RTIDIQP 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 307 CAEELGNNVKPAVTLlgniHAVTKQLLEELDKTPWQYPPESKwwktlreKMKSNEAASKElaskkslPMNYYTVFYHVQE 386
Cdd:COG3961 310 DSVRVGGHIYPGVSL----ADFLEALAELLKKRSAPLPAPAP-------PPPPPPAAPDA-------PLTQDRLWQRLQA 371
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 387 QLPRDCFVVSE------GANTMDI--GRTVL-QNYlprhrldagtFGTMGVGLGFAIAAAVVAKDRSPgqwIICVeGDSA 457
Cdd:COG3961 372 FLDPGDIVVADtgtslfGAADLRLpeGATFIaQPL----------WGSIGYTLPAALGAALAAPDRRV---ILLV-GDGA 437
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 458 FGFSGMEVETICRYNLPIILLVVNNNG-----IYQGFDTDtwkemlkFQDatavvppmclLPNSHYEQVMTAFGGKGYF- 531
Cdd:COG3961 438 FQLTAQELSTMLRYGLKPIIFVLNNDGytierAIHGPDGP-------YND----------IANWDYAKLPEAFGGGNALg 500
|
570 580 590
....*....|....*....|....*....|...
gi 93004078 532 --VQTPEELQKSLRQSLADTTKPSLINIMIEPQ 562
Cdd:COG3961 501 frVTTEGELEEALAAAEANTDRLTLIEVVLDKM 533
|
|
| PRK06546 |
PRK06546 |
pyruvate dehydrogenase; Provisional |
17-563 |
1.86e-32 |
|
pyruvate dehydrogenase; Provisional
Pssm-ID: 180614 [Multi-domain] Cd Length: 578 Bit Score: 131.65 E-value: 1.86e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 17 AKVIAQALKTQDVEYIFGIVGIPVTEIAIAAQQ-LGIKYIGMRNEQAACYAASAIGYLTSRPGVCLVVSGPGLIHALGGM 95
Cdd:PRK06546 6 AEQLVEQLVAAGVKRIYGIVGDSLNPIVDAVRRtGGIEWVHVRHEEAAAFAAAAEAQLTGKLAVCAGSCGPGNLHLINGL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 96 ANANMNCWPLLVIGGSSERNQETMGAFQE-FPQveacRLYTK---FSARPSSIEAIPFVIEKAVRSSIyGRPGACYVDIP 171
Cdd:PRK06546 86 YDAHRSGAPVLAIASHIPSAQIGSGFFQEtHPD----RLFVEcsgYCEMVSSAEQAPRVLHSAIQHAV-AGGGVSVVTLP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 172 ADFVNLQVNVNSIKYMERCmSPPISMAETSAVCTAASVIRNAKQPLLIIGKGAAYAHAEesIKKLVEQYKLPFLPTPMGK 251
Cdd:PRK06546 161 GDIADEPAPEGFAPSVISP-RRPTVVPDPAEVRALADAINEAKKVTLFAGAGVRGAHAE--VLALAEKIKAPVGHSLRGK 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 252 GVVPDNHPYCVG-------AARSRALQFADVIVLFGARLnwilhfglpPRYQ--PDVKFIQVDICAEELGNNVKPAVTLL 322
Cdd:PRK06546 238 EWIQYDNPFDVGmsgllgyGAAHEAMHEADLLILLGTDF---------PYDQflPDVRTAQVDIDPEHLGRRTRVDLAVH 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 323 GNIHAVTKQLLEELD-KTPWQYPPeskwwKTLREKMKSNEAASKELASK--KSLPMNYYTVFYHVQEQLPRDC-FVVSEG 398
Cdd:PRK06546 309 GDVAETIRALLPLVKeKTDRRFLD-----RMLKKHARKLEKVVGAYTRKveKHTPIHPEYVASILDELAADDAvFTVDTG 383
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 399 ANTMDIGRTVLQNylPRHRLdAGTF--GTMGVGLGFAIAAAVVakdrSPGQWIICVEGDSAFGFSGMEVETICRYNLPII 476
Cdd:PRK06546 384 MCNVWAARYITPN--GRRRV-IGSFrhGSMANALPHAIGAQLA----DPGRQVISMSGDGGLSMLLGELLTVKLYDLPVK 456
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 477 LLVVNNNGIyqgfdtdtwkEMLKFQDATAVVPPMCL-LPNSHYEQVMTAFGGKGYFVQTPEELQKSLRQSLAdTTKPSLI 555
Cdd:PRK06546 457 VVVFNNSTL----------GMVKLEMLVDGLPDFGTdHPPVDYAAIAAALGIHAVRVEDPKDVRGALREAFA-HPGPALV 525
|
....*...
gi 93004078 556 NIMIEPQA 563
Cdd:PRK06546 526 DVVTDPNA 533
|
|
| PRK09124 |
PRK09124 |
ubiquinone-dependent pyruvate dehydrogenase; |
17-562 |
5.51e-31 |
|
ubiquinone-dependent pyruvate dehydrogenase;
Pssm-ID: 181661 [Multi-domain] Cd Length: 574 Bit Score: 127.41 E-value: 5.51e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 17 AKVIAQALKTQDVEYIFGIVGIPVTEIAIAAQQLG-IKYIGMRNEQAACYAASAIGYLTSRPGVCLVVSGPGLIHALGGM 95
Cdd:PRK09124 6 ADYIAKTLEQAGVKRIWGVTGDSLNGLSDSLRRMGtIEWMHTRHEEVAAFAAGAEAQLTGELAVCAGSCGPGNLHLINGL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 96 ANANMNCWPLLVIGG---SSERNqetMGAFQE-FPQ--VEACRLYTKFSARPssiEAIPFVIEKAVRSSIyGRPGACYVD 169
Cdd:PRK09124 86 FDCHRNHVPVLAIAAhipSSEIG---SGYFQEtHPQelFRECSHYCELVSNP---EQLPRVLAIAMRKAI-LNRGVAVVV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 170 IPADfVNLQVNVNSIKYMERCMSPPISMAETSAVCTAASVIRNAKQPLLIIGKGAAYAHAEesIKKLVEQYKLPFLPTPM 249
Cdd:PRK09124 159 LPGD-VALKPAPERATPHWYHAPQPVVTPAEEELRKLAALLNGSSNITLLCGSGCAGAHDE--LVALAETLKAPIVHALR 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 250 GKGVVPDNHPYCVG-------AARSRALQFADVIVLFGARlnwilhFGLPPRYQPDVKFIQVDICAEELGNNVKPAVTLL 322
Cdd:PRK09124 236 GKEHVEYDNPYDVGmtgligfSSGYHAMMNCDTLLMLGTD------FPYRQFYPTDAKIIQIDINPGSLGRRSPVDLGLV 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 323 GNIHAVTKQLLEELD-KTPWQYppeskwwktLREKMKSNEAASKEL-----ASKKSLPMnyytvfyHVQeQLPRdcfVVS 396
Cdd:PRK09124 310 GDVKATLAALLPLLEeKTDRKF---------LDKALEHYRKARKGLddlavPSDGGKPI-------HPQ-YLAR---QIS 369
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 397 EGAN-----TMDIGRTVL--QNYLP---RHRLdAGTF--GTMGVGLGFAIAAAVVAKDRSpgqwIICVEGDSafGFSGM- 463
Cdd:PRK09124 370 EFAAddaifTCDVGTPTVwaARYLKmngKRRL-LGSFnhGSMANAMPQALGAQAAHPGRQ----VVALSGDG--GFSMLm 442
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 464 -EVETICRYNLPIILLVVNNNGIyqGFdtdTWKEMlkfqDATAVVPPMCLLPNSHYEQVMTAFGGKGYFVQTPEELQKSL 542
Cdd:PRK09124 443 gDFLSLVQLKLPVKIVVFNNSVL--GF---VAMEM----KAGGYLTDGTDLHNPDFAAIAEACGITGIRVEKASELDGAL 513
|
570 580
....*....|....*....|
gi 93004078 543 RQSLAdTTKPSLINIMIEPQ 562
Cdd:PRK09124 514 QRAFA-HDGPALVDVVTAKQ 532
|
|
| PRK08327 |
PRK08327 |
thiamine pyrophosphate-requiring protein; |
14-551 |
1.41e-30 |
|
thiamine pyrophosphate-requiring protein;
Pssm-ID: 236243 [Multi-domain] Cd Length: 569 Bit Score: 125.88 E-value: 1.41e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 14 VSGAKVIAQALKTQDVEYIFGIVG---IPVTEIAIAAQQLGIK---YIGMRNEQAAcyAASAIGY--LTSRPGVCLVVSG 85
Cdd:PRK08327 7 YTAAELFLELLKELGVDYIFINSGtdyPPIIEAKARARAAGRPlpeFVICPHEIVA--ISMAHGYalVTGKPQAVMVHVD 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 86 PGLIHALGGMANANMNCWPLLVIGGSSERNQEtmGAF----------QE-FPQVEACRLYTKFSARPSSIEAIPFVIEKA 154
Cdd:PRK08327 85 VGTANALGGVHNAARSRIPVLVFAGRSPYTEE--GELgsrntrihwtQEmRDQGGLVREYVKWDYEIRRGDQIGEVVARA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 155 VRSSIYGRPGACYVDIPADFVNLQVNVNSIkYMERCMSPPISMAETSAVCTAASVIRNAKQPLLIIGKGAAYAHAEESIK 234
Cdd:PRK08327 163 IQIAMSEPKGPVYLTLPREVLAEEVPEVKA-DAGRQMAPAPPAPDPEDIARAAEMLAAAERPVIITWRAGRTAEGFASLR 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 235 KLVEQYKLP---FLPTPMgkgVVPDNHPYCVGAARSRALQFADVIVLFGARLNWILHFGLPPryqPDVKFIQVDIcaeel 311
Cdd:PRK08327 242 RLAEELAIPvveYAGEVV---NYPSDHPLHLGPDPRADLAEADLVLVVDSDVPWIPKKIRPD---ADARVIQIDV----- 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 312 gNNVKPAVTLLG-----NIHAVTK---QLLEELDKTPWQYPPESKWWKTLREKMKSNEAASKELASKKSL----PMNYYT 379
Cdd:PRK08327 311 -DPLKSRIPLWGfpcdlCIQADTStalDQLEERLKSLASAERRRARRRRAAVRELRIRQEAAKRAEIERLkdrgPITPAY 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 380 VFYHVQEQLPRDCFVVSEgantmdigRTVLQNYLPRHRldAGTFGTMGV--GLGFAIAAAVVAKDRSPGQWIICVEGDSA 457
Cdd:PRK08327 390 LSYCLGEVADEYDAIVTE--------YPFVPRQARLNK--PGSYFGDGSagGLGWALGAALGAKLATPDRLVIATVGDGS 459
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 458 FGFSgmeVETIC-----RYNLPIiLLVVNNNGIYQGFDTDTwKEMlkFQDATAV----VPPMCLLPNSHYEQVMTAFGGK 528
Cdd:PRK08327 460 FIFG---VPEAAhwvaeRYGLPV-LVVVFNNGGWLAVKEAV-LEV--YPEGYAArkgtFPGTDFDPRPDFAKIAEAFGGY 532
|
570 580
....*....|....*....|...
gi 93004078 529 GYFVQTPEELQKSLRQSLADTTK 551
Cdd:PRK08327 533 GERVEDPEELKGALRRALAAVRK 555
|
|
| TPP_enzymes |
cd00568 |
Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic ... |
384-559 |
1.67e-30 |
|
Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and the branched chain alpha-keto acid dehydrogenase complexes.
Pssm-ID: 238318 [Multi-domain] Cd Length: 168 Bit Score: 116.97 E-value: 1.67e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 384 VQEQLPRDCFVVSEGANTMDIGRTVLQNYLPRHRLDAGTFGTMGVGLGFAIAAAVVAKDRSpgqwIICVEGDSAFGFSGM 463
Cdd:cd00568 6 LRAALPEDAIVVNDAGNSAYWAYRYLPLRRGRRFLTSTGFGAMGYGLPAAIGAALAAPDRP----VVCIAGDGGFMMTGQ 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 464 EVETICRYNLPIILlVVNNNGIYQgfdtDTWKEMLKFQDATavvPPMCLLPNSHYEQVMTAFGGKGYFVQTPEELQKSLR 543
Cdd:cd00568 82 ELATAVRYGLPVIV-VVFNNGGYG----TIRMHQEAFYGGR---VSGTDLSNPDFAALAEAYGAKGVRVEDPEDLEAALA 153
|
170
....*....|....*.
gi 93004078 544 QSLAdTTKPSLINIMI 559
Cdd:cd00568 154 EALA-AGGPALIEVKT 168
|
|
| PRK11269 |
PRK11269 |
glyoxylate carboligase; Provisional |
24-560 |
6.80e-30 |
|
glyoxylate carboligase; Provisional
Pssm-ID: 183066 [Multi-domain] Cd Length: 591 Bit Score: 124.32 E-value: 6.80e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 24 LKTQDVEYIFGIVGIPVTEIAIAAQQLG-IKYIGMRNEQAACYAASaiGYLTSRPG---VCLVVSGPGLIHALGGMANAN 99
Cdd:PRK11269 14 LEKEGVTTAFGVPGAAINPFYSAMRKHGgIRHILARHVEGASHMAE--GYTRATAGnigVCIGTSGPAGTDMITGLYSAS 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 100 MNCWPLLVIGGSSERNQETMGAFQEFPQVEACRLYTKFSARPSSIEAIPFVIEKAVRSSIYGRPGACYVDIPADfvnlqV 179
Cdd:PRK11269 92 ADSIPILCITGQAPRARLHKEDFQAVDIESIAKPVTKWAVTVREPALVPRVFQQAFHLMRSGRPGPVLIDLPFD-----V 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 180 NVNSIKYMERCMSP-PISMAETS--AVCTAASVIRNAKQPLLIIGKGAAYAHAEESIKKLVEQYKLPFLPTPMGKGVVPD 256
Cdd:PRK11269 167 QVAEIEFDPDTYEPlPVYKPAATraQIEKALEMLNAAERPLIVAGGGVINADASDLLVEFAELTGVPVIPTLMGWGAIPD 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 257 NHPYCVGAArsrALQFA-----------DVIVLFGARlnWI-LHFGLPPRYQPDVKFIQVDICAEELGNNVKPAVTLLGN 324
Cdd:PRK11269 247 DHPLMAGMV---GLQTShrygnatllasDFVLGIGNR--WAnRHTGSVEVYTKGRKFVHVDIEPTQIGRVFGPDLGIVSD 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 325 IHAVTKQLLEELD--KTPWQYPPESKWWKTLREKmksneaasKELASKKS----LPMNYYTVFYHVQEQLPRD-CFVVSE 397
Cdd:PRK11269 322 AKAALELLVEVARewKAAGRLPDRSAWVADCQER--------KRTLLRKThfdnVPIKPQRVYEEMNKAFGRDtCYVSTI 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 398 GANTMdIGRTVLQNYLPRHRLDAGTFGTmgvgLGFAIAAAVVAKDRSPGQWIICVEGDSAFGFSGMEVETICRYNLPIIL 477
Cdd:PRK11269 394 GLSQI-AAAQFLHVYKPRHWINCGQAGP----LGWTIPAALGVRAADPDRNVVALSGDYDFQFLIEELAVGAQFNLPYIH 468
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 478 LVVNNN--G-IYQ---GFDTDtWKEMLKFQDATAvvPPMCLLPNSHYeQVMTAFGGKGYFVQTPEELQKSLRQS---LAD 548
Cdd:PRK11269 469 VLVNNAylGlIRQaqrAFDMD-YCVQLAFENINS--PELNGYGVDHV-KVAEGLGCKAIRVFKPEDIAPALEQAkalMAE 544
|
570
....*....|..
gi 93004078 549 TTKPSLINIMIE 560
Cdd:PRK11269 545 FRVPVVVEVILE 556
|
|
| TPP_enzyme_C |
pfam02775 |
Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; |
398-557 |
7.12e-30 |
|
Thiamine pyrophosphate enzyme, C-terminal TPP binding domain;
Pssm-ID: 460689 [Multi-domain] Cd Length: 151 Bit Score: 114.60 E-value: 7.12e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 398 GANTMDIGRtVLQNYLPRHRLDAGTFGTMGVGLGFAIAAAVVAKDRSpgqwIICVEGDSAFGFSGMEVETICRYNLPIIL 477
Cdd:pfam02775 3 GCHQMWAAQ-YYRFRPPRRYLTSGGLGTMGYGLPAAIGAKLARPDRP----VVAIAGDGGFQMNLQELATAVRYNLPITV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 478 LVVNNNGiyQGFdTDTWKEMlkFQDATAVVPPMCLLPNSHYEQVMTAFGGKGYFVQTPEELQKSLRQSLaDTTKPSLINI 557
Cdd:pfam02775 78 VVLNNGG--YGM-TRGQQTP--FGGGRYSGPSGKILPPVDFAKLAEAYGAKGARVESPEELEEALKEAL-EHDGPALIDV 151
|
|
| TPP_PYR_POX |
cd07039 |
Pyrimidine (PYR) binding domain of POX; Thiamine pyrophosphate (TPP family), pyrimidine (PYR) ... |
17-174 |
8.49e-30 |
|
Pyrimidine (PYR) binding domain of POX; Thiamine pyrophosphate (TPP family), pyrimidine (PYR) binding domain of pyruvate oxidase (POX) subfamily. The PYR domain is found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. TPP binds in the cleft formed by a PYR domain and a PP domain. The PYR domain, binds the aminopyrimidine ring of TPP, the PP domain binds the diphosphate residue. The PYR and PP domains have a common fold, but do not share strong sequence conservation. The PP domain is not included in this sub-family. Most TPP-dependent enzymes have the PYR and PP domains on the same subunit although these domains can be alternatively arranged in the primary structure. TPP-dependent enzymes are multisubunit proteins, the smallest catalytic unit being a dimer-of-active sites. Lactobacillus plantarum POX is a homotetramer (dimer-of-homodimers), having two active sites per homodimer lying between PYR and PP domains of different subunits. POX decarboxylates pyruvate, producing hydrogen peroxide and the energy-storage metabolite acetylphosphate.
Pssm-ID: 132922 [Multi-domain] Cd Length: 164 Bit Score: 114.96 E-value: 8.49e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 17 AKVIAQALKTQDVEYIFGIVGIPVTEIAIAAQ-QLGIKYIGMRNEQAACYAASAIGYLTSRPGVCLVVSGPGLIHALGGM 95
Cdd:cd07039 3 ADVIVETLENWGVKRVYGIPGDSINGLMDALRrEGKIEFIQVRHEEAAAFAASAEAKLTGKLGVCLGSSGPGAIHLLNGL 82
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 93004078 96 ANANMNCWPLLVIGGSSERNQETMGAFQEFPQVEACRLYTKFSARPSSIEAIPFVIEKAVRSSIyGRPGACYVDIPADF 174
Cdd:cd07039 83 YDAKRDRAPVLAIAGQVPTDELGTDYFQEVDLLALFKDVAVYNETVTSPEQLPELLDRAIRTAI-AKRGVAVLILPGDV 160
|
|
| PRK08273 |
PRK08273 |
thiamine pyrophosphate protein; Provisional |
20-561 |
5.08e-28 |
|
thiamine pyrophosphate protein; Provisional
Pssm-ID: 181344 [Multi-domain] Cd Length: 597 Bit Score: 118.47 E-value: 5.08e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 20 IAQALKTQDVEYIF-----GIVGIPVteiAIAAQQLGIKYIGMRNEQAACYAASAIGYLTSRPGVCLVVSGPGLIHALGG 94
Cdd:PRK08273 9 ILERLREWGVRRVFgypgdGINGLLG---ALGRADDKPEFVQARHEEMAAFMAVAHAKFTGEVGVCLATSGPGAIHLLNG 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 95 MANANMNCWPLLVIGGSSERNqeTMGA-FQEfpQVEACRLY----TKFSARPSSIEAIPFVIEKAVRSSIYGRPGACyVD 169
Cdd:PRK08273 86 LYDAKLDHVPVVAIVGQQARA--ALGGhYQQ--EVDLQSLFkdvaGAFVQMVTVPEQLRHLVDRAVRTALAERTVTA-VI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 170 IPADFVNLQVN---------VNSIKYmercmSPPISMAETSAVCTAASVIRNAKQPLLIIGKGAAYAHAEesIKKLVEQY 240
Cdd:PRK08273 161 LPNDVQELEYEppphahgtvHSGVGY-----TRPRVVPYDEDLRRAAEVLNAGRKVAILVGAGALGATDE--VIAVAERL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 241 KLPFLPTPMGKGVVPDNHPYCVGAarsralqfadvIVLFGARLNW--------ILHFG--------LPPRYQpdVKFIQV 304
Cdd:PRK08273 234 GAGVAKALLGKAALPDDLPWVTGS-----------IGLLGTKPSYelmrecdtLLMVGssfpysefLPKEGQ--ARGVQI 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 305 DICAEELGNNVKPAVTLLGNIHAVTKQLLEELDKTP---WQYPPES---KWWKTLREkmKSNEAASkelaskkslPMNYY 378
Cdd:PRK08273 301 DIDGRMLGLRYPMEVNLVGDAAETLRALLPLLERKKdrsWRERIEKwvaRWWETLEA--RAMVPAD---------PVNPQ 369
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 379 TVFYHVQEQLPRDCFVvseganTMDIGRTVlqNYLPRH-RLD-------AGTFGTMGVGLGFAIAAAVVAKDRSpgqwII 450
Cdd:PRK08273 370 RVFWELSPRLPDNAIL------TADSGSCA--NWYARDlRMRrgmmaslSGTLATMGPAVPYAIAAKFAHPDRP----VI 437
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 451 CVEGDSAFGFSGM-EVETICRY-----NLPIILLVVNNNGIYQgfdtDTW--KEML---KFQDATAvvppmclLPNSHYE 519
Cdd:PRK08273 438 ALVGDGAMQMNGMaELITVAKYwrqwsDPRLIVLVLNNRDLNQ----VTWeqRVMEgdpKFEASQD-------LPDVPYA 506
|
570 580 590 600
....*....|....*....|....*....|....*....|..
gi 93004078 520 QVMTAFGGKGYFVQTPEELQKSLRQSLAdTTKPSLINIMIEP 561
Cdd:PRK08273 507 RFAELLGLKGIRVDDPEQLGAAWDEALA-ADRPVVLEVKTDP 547
|
|
| PRK07092 |
PRK07092 |
benzoylformate decarboxylase; Reviewed |
69-560 |
4.70e-26 |
|
benzoylformate decarboxylase; Reviewed
Pssm-ID: 235931 [Multi-domain] Cd Length: 530 Bit Score: 111.97 E-value: 4.70e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 69 AIGY--LTSRPGVCLVVSGPGLIHALGGMANANMNCWPLLVIGGSSERN---QETM-GAFQ--EFPqveacRLYTKFSAR 140
Cdd:PRK07092 64 ADGYaqATGNAAFVNLHSAAGVGNAMGNLFTAFKNHTPLVITAGQQARSilpFEPFlAAVQaaELP-----KPYVKWSIE 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 141 PSSIEAIPFVIEKAVRSSIYGRPGACYVDIPADfvnlqvnvnsiKYMERCmsPPISMAETSAVC--------TAASVIRN 212
Cdd:PRK07092 139 PARAEDVPAAIARAYHIAMQPPRGPVFVSIPYD-----------DWDQPA--EPLPARTVSSAVrpdpaalaRLGDALDA 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 213 AKQPLLIIGKGAAYAHAEESIKKLVEQYKLPFLPTPM-GKGVVPDNHPYCVG---AAR---SRALQFADVIVLFGARLNw 285
Cdd:PRK07092 206 ARRPALVVGPAVDRAGAWDDAVRLAERHRAPVWVAPMsGRCSFPEDHPLFAGflpASRekiSALLDGHDLVLVIGAPVF- 284
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 286 ILHFGLPPRYQPD-VKFIQVDICAEELGnnVKPAVT-LLGNIHAVTKQLLEELDKTPWQYPPEskwwktlREKMKSNEAA 363
Cdd:PRK07092 285 TYHVEGPGPHLPEgAELVQLTDDPGEAA--WAPMGDaIVGDIRLALRDLLALLPPSARPAPPA-------RPMPPPAPAP 355
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 364 SKelaskkslPMNYYTVFYHVQEQLPRDCFVVSEGANTmdigRTVLQNYLPRHRldAGTFGTMGVG-LGFAIAAAVVAKD 442
Cdd:PRK07092 356 GE--------PLSVAFVLQTLAALRPADAIVVEEAPST----RPAMQEHLPMRR--QGSFYTMASGgLGYGLPAAVGVAL 421
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 443 RSPGQWIICVEGDSAFGFSGMEVETICRYNLPIILLVVNNN--GIYQGFDTdtwkeMLKFQDAtavvpPMCLLPNSHYEQ 520
Cdd:PRK07092 422 AQPGRRVIGLIGDGSAMYSIQALWSAAQLKLPVTFVILNNGryGALRWFAP-----VFGVRDV-----PGLDLPGLDFVA 491
|
490 500 510 520
....*....|....*....|....*....|....*....|
gi 93004078 521 VMTAFGGKGYFVQTPEELQKSLRQSLADtTKPSLINIMIE 560
Cdd:PRK07092 492 LARGYGCEAVRVSDAAELADALARALAA-DGPVLVEVEVA 530
|
|
| TPP_Xsc_like |
cd02013 |
Thiamine pyrophosphate (TPP) family, Xsc-like subfamily, TPP-binding module; composed of ... |
373-563 |
5.45e-21 |
|
Thiamine pyrophosphate (TPP) family, Xsc-like subfamily, TPP-binding module; composed of proteins similar to Alcaligenes defragrans sulfoacetaldehyde acetyltransferase (Xsc). Xsc plays a key role in the degradation of taurine, catalyzing the desulfonation of 2-sulfoacetaldehyde into sulfite and acetyl phosphate. This enzyme requires TPP and divalent metal ions for activity.
Pssm-ID: 238971 [Multi-domain] Cd Length: 196 Bit Score: 91.03 E-value: 5.45e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 373 LPMNYYTVFYHVQEQLPRDCFVVSEGANTMDIGRTVLQNYLPRHRLDAGTFGTmgvgLGFAIAAAVVAKDRSPGQWIICV 452
Cdd:cd02013 2 NPMHPRQVLRELEKAMPEDAIVSTDIGNICSVANSYLRFEKPRSFIAPLSFGN----CGYALPAIIGAKAAAPDRPVVAI 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 453 EGDSAFGFSGMEVETICRYNLPIILLVvnnngiyqgFDTDTW----KEMLKFQDATAVVPPmclLPNSHYEQVMTAFGGK 528
Cdd:cd02013 78 AGDGAWGMSMMEIMTAVRHKLPVTAVV---------FRNRQWgaekKNQVDFYNNRFVGTE---LESESFAKIAEACGAK 145
|
170 180 190
....*....|....*....|....*....|....*..
gi 93004078 529 GYFVQTPEELQKSLRQSLADTT--KPSLINIMIEPQA 563
Cdd:cd02013 146 GITVDKPEDVGPALQKAIAMMAegKTTVIEIVCDQEL 182
|
|
| TPP_POX |
cd02014 |
Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; ... |
374-563 |
9.09e-21 |
|
Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates pyruvate, producing hydrogen peroxide and the energy-storage metabolite acetylphosphate. It requires FAD in addition to TPP and a divalent cation as cofactors.
Pssm-ID: 238972 [Multi-domain] Cd Length: 178 Bit Score: 89.90 E-value: 9.09e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 374 PMNYYTVFYHVQEQLPRDC-FVVSEGANTMDIGRtvlqnYLPRHR----LDAGTFGTMGVGLGFAIAAAVVAKDRSpgqw 448
Cdd:cd02014 1 PIHPERVAAELNKRAPDDAiFTIDVGNVTVWAAR-----HLRMNGkqrfILSGLLATMGNGLPGAIAAKLAYPDRQ---- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 449 IICVEGDSAFGFSGMEVETICRYNLPIILLVVNNNGIyqGFdtDTWKEMLKFQDATAVVppmclLPNSHYEQVMTAFGGK 528
Cdd:cd02014 72 VIALSGDGGFAMLMGDLITAVKYNLPVIVVVFNNSDL--GF--IKWEQEVMGQPEFGVD-----LPNPDFAKIAEAMGIK 142
|
170 180 190
....*....|....*....|....*....|....*
gi 93004078 529 GYFVQTPEELQKSLRQSLAdTTKPSLINIMIEPQA 563
Cdd:cd02014 143 GIRVEDPDELEAALDEALA-ADGPVVIDVVTDPNE 176
|
|
| TPP_AHAS |
cd02015 |
Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding ... |
384-563 |
2.33e-19 |
|
Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the acetohydroxyacid, 2-acetolactate. 2-Acetolactate is the precursor of the branched chain amino acids, valine and leucine. AHAS also catalyzes the condensation of pyruvate and 2-ketobutyrate to form 2-aceto-2-hydroxybutyrate in isoleucine biosynthesis. In addition to requiring TPP and a divalent metal ion as cofactors, AHAS requires FAD.
Pssm-ID: 238973 [Multi-domain] Cd Length: 186 Bit Score: 86.01 E-value: 2.33e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 384 VQEQLPRDCFVVSE-GANTMDIGRTvLQNYLPRHRLDAGTFGTMGVGLGFAIAAAVVAKDRSpgqwIICVEGDSAFGFSG 462
Cdd:cd02015 10 LSELTPGDAIVTTDvGQHQMWAAQY-YRFKKPRSWLTSGGLGTMGFGLPAAIGAKVARPDKT----VICIDGDGSFQMNI 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 463 MEVETICRYNLPIILLVVNNNgiYQGfdtdtwkeMLK-FQDA------TAVVPPMCllPNshYEQVMTAFGGKGYFVQTP 535
Cdd:cd02015 85 QELATAAQYNLPVKIVILNNG--SLG--------MVRqWQELfyegrySHTTLDSN--PD--FVKLAEAYGIKGLRVEKP 150
|
170 180
....*....|....*....|....*...
gi 93004078 536 EELQKSLRQSLaDTTKPSLINIMIEPQA 563
Cdd:cd02015 151 EELEAALKEAL-ASDGPVLLDVLVDPEE 177
|
|
| TPP_ALS |
cd02010 |
Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; ... |
380-560 |
7.49e-18 |
|
Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2 molecules of pyruvate to acetolactate and carbon dioxide. ALS does not contain FAD, and requires TPP and a divalent metal cation for activity.
Pssm-ID: 238968 [Multi-domain] Cd Length: 177 Bit Score: 81.57 E-value: 7.49e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 380 VFYHVQEQLPRDCFVVSE-GANTMDIGRtVLQNYLPRHRLDAGTFGTMGVGLGFAIAAAVVakdrSPGQWIICVEGDSAF 458
Cdd:cd02010 4 IVHDLRAVMGDDDIVLLDvGAHKIWMAR-YYRTYAPNTCLISNGLATMGVALPGAIGAKLV----YPDRKVVAVSGDGGF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 459 GFSGMEVETICRYNLPIILLVVNNNgiyqGFDTDTWKEMLKFQDATAVVppmclLPNSHYEQVMTAFGGKGYFVQTPEEL 538
Cdd:cd02010 79 MMNSQELETAVRLKIPLVVLIWNDN----GYGLIKWKQEKEYGRDSGVD-----FGNPDFVKYAESFGAKGYRIESADDL 149
|
170 180
....*....|....*....|..
gi 93004078 539 QKSLRQSLADtTKPSLINIMIE 560
Cdd:cd02010 150 LPVLERALAA-DGVHVIDCPVD 170
|
|
| TPP_PDC_IPDC |
cd02005 |
Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of ... |
421-561 |
2.53e-15 |
|
Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of pyruvate to acetaldehyde and CO2. It is able to utilize other 2-oxo acids as substrates. In plants and various plant-associated bacteria, IPDC plays a role in the indole-3-pyruvic acid (IPA) pathway, a tryptophan-dependent biosynthetic route to indole-3-acetaldehyde (IAA). IPDC catalyzes the decarboxylation of IPA to IAA. Both PDC and IPDC depend on TPP and Mg2+ as cofactors.
Pssm-ID: 238963 [Multi-domain] Cd Length: 183 Bit Score: 74.11 E-value: 2.53e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 421 GTFGTMGVGLGFAIAAAVVAKDRSPgqwiICVEGDSAFGFSGMEVETICRYNLPIILLVVNNNGiYqgfdtdtwkEMLK- 499
Cdd:cd02005 47 PLWGSIGYSVPAALGAALAAPDRRV----ILLVGDGSFQMTVQELSTMIRYGLNPIIFLINNDG-Y---------TIERa 112
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 93004078 500 FQDATA---VVPPMcllpnsHYEQVMTAFG----GKGYFVQTPEELQKSLRQSLADTTKPSLINIMIEP 561
Cdd:cd02005 113 IHGPEAsynDIANW------NYTKLPEVFGggggGLSFRVKTEGELDEALKDALFNRDKLSLIEVILPK 175
|
|
| TPP_BFDC |
cd02002 |
Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins ... |
375-559 |
3.52e-15 |
|
Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of benzoylformate to benzaldehyde and carbon dioxide. This enzyme is dependent on TPP and a divalent metal cation as cofactors.
Pssm-ID: 238960 [Multi-domain] Cd Length: 178 Bit Score: 73.78 E-value: 3.52e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 375 MNYYTVFYHVQEQLPRDCFVVSEGANTMDigrtVLQNYLPRHRLDaGTFGTMGVGLGFAIAAAVVAKDRSPGQWIICVEG 454
Cdd:cd02002 1 LTPEYLAAALAAALPEDAIIVDEAVTNGL----PLRDQLPLTRPG-SYFTLRGGGLGWGLPAAVGAALANPDRKVVAIIG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 455 DSAFGFSGMEVETICRYNLPIILLVVNNNG--IYQGFDTDTWKEMLKFQdatAVVPPMCLLPNSHYEQVMTAFGGKGYFV 532
Cdd:cd02002 76 DGSFMYTIQALWTAARYGLPVTVVILNNRGygALRSFLKRVGPEGPGEN---APDGLDLLDPGIDFAAIAKAFGVEAERV 152
|
170 180
....*....|....*....|....*..
gi 93004078 533 QTPEELQKSLRQSLADtTKPSLINIMI 559
Cdd:cd02002 153 ETPEELDEALREALAE-GGPALIEVVV 178
|
|
| TPP_enzyme_PYR |
cd06586 |
Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Thiamine ... |
18-172 |
2.93e-14 |
|
Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Thiamine pyrophosphate (TPP) family, pyrimidine (PYR) binding domain; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. TPP binds in the cleft formed by a PYR domain and a PP domain. The PYR domain, binds the aminopyrimidine ring of TPP, the PP domain binds the diphosphate residue. A polar interaction between the conserved glutamate of the PYR domain and the N1' of the TPP aminopyrimidine ring is shared by most TPP-dependent enzymes, and participates in the activation of TPP. The PYR and PP domains have a common fold, but do not share strong sequence conservation. The PP domain is not included in this group. Most TPP-dependent enzymes have the PYR and PP domains on the same subunit although these domains can be alternatively arranged in the primary structure. In the case of 2-oxoisovalerate dehydrogenase (2OXO), sulfopyruvate decarboxylase (ComDE), and the E1 component of human pyruvate dehydrogenase complex (E1- PDHc) the PYR and PP domains appear on different subunits. TPP-dependent enzymes are multisubunit proteins, the smallest catalytic unit being a dimer-of-active sites. For many of these enzymes the active sites lie between PP and PYR domains on different subunits. However, for the homodimeric enzymes 1-deoxy-D-xylulose 5-phosphate synthase (DXS) and Desulfovibrio africanus pyruvate:ferredoxin oxidoreductase (PFOR), each active site lies at the interface of the PYR and PP domains from the same subunit.
Pssm-ID: 132915 [Multi-domain] Cd Length: 154 Bit Score: 70.45 E-value: 2.93e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 18 KVIAQALKTQDVEYIFGIVGIPVTEI--AIAAQQlGIKYIGMRNEQAACYAASAIGYLTSRPgVCLVVSGPGLIHALGGM 95
Cdd:cd06586 1 AAFAEVLTAWGVRHVFGYPGDEISSLldALREGD-KRIIDTVIHELGAAGAAAGYARAGGPP-VVIVTSGTGLLNAINGL 78
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 93004078 96 ANANMNCWPLLVIGGSSERNQETMGAFQEFPQVEACRLYTKFSARPSSIEAIPFVIEKAVRSSiYGRPGACYVDIPA 172
Cdd:cd06586 79 ADAAAEHLPVVFLIGARGISAQAKQTFQSMFDLGMYRSIPEANISSPSPAELPAGIDHAIRTA-YASQGPVVVRLPR 154
|
|
| PLN02573 |
PLN02573 |
pyruvate decarboxylase |
51-484 |
1.54e-12 |
|
pyruvate decarboxylase
Pssm-ID: 215311 [Multi-domain] Cd Length: 578 Bit Score: 70.11 E-value: 1.54e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 51 GIKYIGMRNEQAACYAASaiGYLTSRP-GVCLV---VSGPGLIHALGGMANANMncwPLLVIGGSSERN--------QET 118
Cdd:PLN02573 54 GLNLIGCCNELNAGYAAD--GYARARGvGACVVtftVGGLSVLNAIAGAYSENL---PVICIVGGPNSNdygtnrilHHT 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 119 MGAfQEFPQVEAC-RLYTKFSARPSSIEAIPFVIEKAVrSSIYGRPGACYVDIPADFVNLQVNVNSIKYMERCMSPPIS- 196
Cdd:PLN02573 129 IGL-PDFSQELRCfQTVTCYQAVINNLEDAHELIDTAI-STALKESKPVYISVSCNLAAIPHPTFSREPVPFFLTPRLSn 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 197 -MAETSAVCTAASVIRNAKQPLLIIGKGAAYAHAEESIKKLVEQYKLPFLPTPMGKGVVPDNHPYCVG---AARSRA--- 269
Cdd:PLN02573 207 kMSLEAAVEAAAEFLNKAVKPVLVGGPKLRVAKACKAFVELADASGYPVAVMPSAKGLVPEHHPHFIGtywGAVSTPfca 286
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 270 --LQFADVIVLFGARLNWILHFGLPPRYQPDvKFIQVDICAEELGNnvKPAvtlLGNIhaVTKQLLEELDKtpwqyppes 347
Cdd:PLN02573 287 eiVESADAYLFAGPIFNDYSSVGYSLLLKKE-KAIIVQPDRVTIGN--GPA---FGCV--LMKDFLEALAK--------- 349
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 348 kwwktlreKMKSNEAA-----------SKELASKKSLPMNYYTVFYHVQEQLPRDCFVVSEganTMDIGRTVLQNYLPR- 415
Cdd:PLN02573 350 --------RVKKNTTAyenykrifvpeGEPLKSEPGEPLRVNVLFKHIQKMLSGDTAVIAE---TGDSWFNCQKLKLPEg 418
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 93004078 416 ----HRLDAGTFG-TMGVGLGFAIAAavvakdrsPGQWIICVEGDSAFGFSGMEVETICRYNLPIILLVVNNNG 484
Cdd:PLN02573 419 cgyeFQMQYGSIGwSVGATLGYAQAA--------PDKRVIACIGDGSFQVTAQDVSTMIRCGQKSIIFLINNGG 484
|
|
| PRK12474 |
PRK12474 |
hypothetical protein; Provisional |
14-559 |
6.66e-08 |
|
hypothetical protein; Provisional
Pssm-ID: 139002 [Multi-domain] Cd Length: 518 Bit Score: 55.26 E-value: 6.66e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 14 VSGAKVIAQALKTQDVEYIFGIVGipVTEIAIAA---QQLGIKYIGMRNEQAACYAASAIGYLTSRPGVCLVVSGPGLIH 90
Cdd:PRK12474 5 MNGADSVVDTLLNCGVEVCFANPG--TSEMHFVAaldRVPRMRPVLCLFEGVVTGAADGYGRIAGKPAVTLLHLGPGLAN 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 91 ALGGMANANMNCWPLLVIGGSSERNQETMGAFQEFPQVEACRLYTKFSARPSSIEAIPFVIEKAVRSSIYGRPGACYVDI 170
Cdd:PRK12474 83 GLANLHNARRAASPIVNIVGDHAVEHLQYDAPLTSDIDGFARPVSRWVHRSASAGAVDSDVARAVQAAQSAPGGIATLIM 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 171 PADfvnlqVNVNSIKYM-ERCMSPPISMAETSAVCTAASVIRNAKQPLLIIGKGAAYAHAEESIKKL-----VEQYKLPF 244
Cdd:PRK12474 163 PAD-----VAWNEAAYAaQPLRGIGPAPVAAETVERIAALLRNGKKSALLLRGSALRGAPLEAAGRIqaktgVRLYCDTF 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 245 LP-TPMGKGVVP-DNHPYcVGAARSRALQFADVIVLFGAR--LNWILHFGLPPRYQPD-VKFIQVDICAEELGNNVKpav 319
Cdd:PRK12474 238 APrIERGAGRVPiERIPY-FHEQITAFLKDVEQLVLVGAKppVSFFAYPGKPSWGAPPgCEIVYLAQPDEDLAQALQ--- 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 320 tllgnihavtkQLLEELDKTpwqyppeskwwktlREKMKSNEAASKELASKKslpMNYYTVFYHVQEQLPrDCFVVSEGA 399
Cdd:PRK12474 314 -----------DLADAVDAP--------------AEPAARTPLALPALPKGA---LNSLGVAQLIAHRTP-DQAIYADEA 364
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 400 NT------MDIGRTVLQNYLPRhrldagTFGTMGVGLGFAIAAAVVAKDRSpgqwIICVEGDSAFGFSGMEVETICRYNL 473
Cdd:PRK12474 365 LTsglffdMSYDRARPHTHLPL------TGGSIGQGLPLAAGAAVAAPDRK----VVCPQGDGGAAYTMQALWTMARENL 434
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 474 PIILLVVNNNGIyqgfdTDTWKEMLKFQDATAVVPPMCLL----PNSHYEQVMTAFGGKGYFVQTPEELQKSLRQSLADt 549
Cdd:PRK12474 435 DVTVVIFANRSY-----AILNGELQRVGAQGAGRNALSMLdlhnPELNWMKIAEGLGVEASRATTAEEFSAQYAAAMAQ- 508
|
570
....*....|
gi 93004078 550 TKPSLINIMI 559
Cdd:PRK12474 509 RGPRLIEAMI 518
|
|
| TPP_Gcl |
cd02006 |
Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins ... |
373-560 |
7.62e-08 |
|
Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the condensation of two molecules of glyoxylate to give tartronic semialdehyde and carbon dioxide. This enzyme requires TPP, magnesium ion and FAD as cofactors.
Pssm-ID: 238964 [Multi-domain] Cd Length: 202 Bit Score: 53.05 E-value: 7.62e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 373 LPMNYYTVFYHVQEQLPRD-CFVVSEGANTMdIGRTVLQNYLPRHRLDAGTFGTmgvgLGFAIAAAVVAKDRSPGQWIIC 451
Cdd:cd02006 6 VPIKPQRVYEEMNKAFGRDvRYVTTIGLSQI-AGAQMLHVYKPRHWINCGQAGP----LGWTVPAALGVAAADPDRQVVA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 452 VEGDSAFGFSGMEVETICRYNLPIILLVVNNNGI------YQGFDTDtWKEMLKFQDATAvvPPMCLLPNSHYeQVMTAF 525
Cdd:cd02006 81 LSGDYDFQFMIEELAVGAQHRIPYIHVLVNNAYLglirqaQRAFDMD-YQVNLAFENINS--SELGGYGVDHV-KVAEGL 156
|
170 180 190
....*....|....*....|....*....|....*...
gi 93004078 526 GGKGYFVQTPEELQKSLRQS---LADTTKPSLINIMIE 560
Cdd:cd02006 157 GCKAIRVTKPEELAAAFEQAkklMAEHRVPVVVEAILE 194
|
|
| TPP_PYR_PDC_IPDC_like |
cd07038 |
Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase ... |
20-172 |
6.32e-06 |
|
Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Thiamine pyrophosphate (TPP family), pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC) subfamily. The PYR domain is found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. TPP binds in the cleft formed by a PYR domain and a PP domain. The PYR domain, binds the aminopyrimidine ring of TPP, the PP domain binds the diphosphate residue. The PYR and PP domains have a common fold, but do not share strong sequence conservation. The PP domain is not included in this sub-family. Most TPP-dependent enzymes have the PYR and PP domains on the same subunit although these domains can be alternatively arranged in the primary structure. TPP-dependent enzymes are multisubunit proteins, the smallest catalytic unit being a dimer-of-active sites, for many the active sites lie between PP and PYR domains on different subunits. PDC catalyzes the conversion of pyruvate to acetaldehyde and CO2 in alcoholic fermentation. IPDC plays a role in the indole-3-pyruvic acid (IPA) pathway in plants and various plant-associated bacteria, it catalyzes the decarboxylation of IPA to IAA. Also belonging to this group is Mycobacterium tuberculosis alpha-keto acid decarboxylase (MtKDC) which participates in amino acid degradation via the Ehrlich pathway, and Lactococcus lactis branched-chain keto acid decarboxylase (KdcA) an enzyme identified as being involved in cheese ripening, which exhibits a very broad substrate range in the decarboxylation and carboligation reactions.
Pssm-ID: 132921 [Multi-domain] Cd Length: 162 Bit Score: 46.33 E-value: 6.32e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 20 IAQALKTQDVEYIFGIVG---IPVTEIAIAAQqlGIKYIGMRNEQAACYAASaiGYL-TSRPGVCLVVSGPGLIHALGGM 95
Cdd:cd07038 3 LLERLKQLGVKHVFGVPGdynLPLLDAIEENP--GLRWVGNCNELNAGYAAD--GYArVKGLGALVTTYGVGELSALNGI 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 96 ANANMNCWPLLVI-GGSSERNQET---------MGAFQEFpqVEACRLYTKFSARPSSIEAIPFVIEKAVRSSI-YGRPG 164
Cdd:cd07038 79 AGAYAEHVPVVHIvGAPSTKAQASglllhhtlgDGDFDVF--LKMFEEITCAAARLTDPENAAEEIDRVLRTALrESRPV 156
|
....*...
gi 93004078 165 acYVDIPA 172
Cdd:cd07038 157 --YIEIPR 162
|
|
| TPP_IolD |
cd02003 |
Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins ... |
416-561 |
2.80e-05 |
|
Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism.
Pssm-ID: 238961 [Multi-domain] Cd Length: 205 Bit Score: 45.37 E-value: 2.80e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 416 HRL-DAGTFGTMGVGLGFA-----IAAAVVAKDRSPGQWIICVEGDSAFGFSGMEVETICRYNLPIILLVVNNNGI---- 485
Cdd:cd02003 30 HKLwRARTPGGYHLEYGYScmgyeIAAGLGAKLAKPDREVYVLVGDGSYLMLHSEIVTAVQEGLKIIIVLFDNHGFgcin 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 486 -------YQGFDTDtwkemLKFQDATAVVPPMCLLPnSHYEQVMTAFGGKGYFVQTPEELQKSLRQSlADTTKPSLINIM 558
Cdd:cd02003 110 nlqestgSGSFGTE-----FRDRDQESGQLDGALLP-VDFAANARSLGARVEKVKTIEELKAALAKA-KASDRTTVIVIK 182
|
...
gi 93004078 559 IEP 561
Cdd:cd02003 183 TDP 185
|
|
| PRK07586 |
PRK07586 |
acetolactate synthase large subunit; |
193-559 |
2.17e-04 |
|
acetolactate synthase large subunit;
Pssm-ID: 236063 [Multi-domain] Cd Length: 514 Bit Score: 44.06 E-value: 2.17e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 193 PPISMAETSAVCTAASVIRNAKQPLLIIGKGAAYAHAEES---------IKKLVEQYklpflPTPM--GKGVVP-DNHPY 260
Cdd:PRK07586 177 PAPAAVDPAAVEAAAAALRSGEPTVLLLGGRALRERGLAAaariaaatgARLLAETF-----PARMerGAGRPAvERLPY 251
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90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 261 CVGAARsRALQFADVIVLFGAR--LNWILHFGLPPRYQPDvkfiqvdicaeelGNNVkpaVTLLG---NIHAVTKQLLEE 335
Cdd:PRK07586 252 FAEQAL-AQLAGVRHLVLVGAKapVAFFAYPGKPSRLVPE-------------GCEV---HTLAGpgeDAAAALEALADA 314
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170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 336 LDKTPwQYPPeskwwktlrekmksneAASKELASKKSLPMNYYTVFYHVQEQLPRDCFVVSEGANTmdiGR---TVLQNy 412
Cdd:PRK07586 315 LGAKP-AAPP----------------LAAPARPPLPTGALTPEAIAQVIAALLPENAIVVDESITS---GRgffPATAG- 373
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250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 413 LPRHRLDAGTFGTMGVGLGFAIAAAVVAKDRSpgqwIICVEGDSAFGFSGMEVETICRYNLPIIlLVVNNNGIYQ----- 487
Cdd:PRK07586 374 AAPHDWLTLTGGAIGQGLPLATGAAVACPDRK----VLALQGDGSAMYTIQALWTQARENLDVT-TVIFANRAYAilrge 448
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 93004078 488 ------GFDTDTWKEMLKFQDatavvppmcllPNSHYEQVMTAFGGKGYFVQTPEELQKSLRQSLADtTKPSLINIMI 559
Cdd:PRK07586 449 larvgaGNPGPRALDMLDLDD-----------PDLDWVALAEGMGVPARRVTTAEEFADALAAALAE-PGPHLIEAVV 514
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| TPP_SHCHC_synthase |
cd02009 |
Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of ... |
424-557 |
1.09e-03 |
|
Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key role in the menaquinone biosynthetic pathway, converting isochorismate and 2-oxoglutarate to SHCHC, pyruvate and carbon dioxide. The enzyme requires TPP and a divalent metal cation for activity.
Pssm-ID: 238967 [Multi-domain] Cd Length: 175 Bit Score: 40.27 E-value: 1.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 424 GTMGVGLGFAIAAavvakdrspGQWIICVEGDSAF-----GFSGMEVETicrynLPIILLVVNNNG--IyqgFDTdtwKE 496
Cdd:cd02009 55 GTLSTALGIALAT---------DKPTVLLTGDLSFlhdlnGLLLGKQEP-----LNLTIVVINNNGggI---FSL---LP 114
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 93004078 497 MLKFQDATAVVPPMCLlpNSHYEQVMTAFGGKGYFVQTPEELQKSLRQSLaDTTKPSLINI 557
Cdd:cd02009 115 QASFEDEFERLFGTPQ--GLDFEHLAKAYGLEYRRVSSLDELEQALESAL-AQDGPHVIEV 172
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|
| TPP_PYR_PFOR_IOR-alpha_like |
cd07034 |
Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ... |
16-108 |
6.46e-03 |
|
Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Thiamine pyrophosphate (TPP family), pyrimidine (PYR) binding domain, of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit (IOR-alpha), and related proteins, subfamily. The PYR domain is found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. TPP binds in the cleft formed by a PYR domain and a PP domain. The PYR domain, binds the aminopyrimidine ring of TPP, the PP domain binds the diphosphate residue. A polar interaction between the conserved glutamate of the PYR domain and the N1' of the TPP aminopyrimidine ring is shared by most TPP-dependent enzymes, and participates in the activation of TPP. The PYR and PP domains have a common fold, but do not share strong sequence conservation. The PP domain is not included in this sub-family. Most TPP-dependent enzymes have the PYR and PP domains on the same subunit although these domains can be alternatively arranged in the primary structure. TPP-dependent enzymes are multisubunit proteins, the smallest catalytic unit being a dimer-of-active sites. For many of these enzymes the active sites lie between PP and PYR domains on different subunits. However, for the homodimeric enzyme Desulfovibrio africanus pyruvate:ferredoxin oxidoreductase (PFOR), each active site lies at the interface of the PYR and PP domains from the same subunit. This subfamily includes proteins characterized as pyruvate NADP+ oxidoreductase (PNO). PFOR and PNO catalyze the oxidative decarboxylation of pyruvate to form acetyl-CoA, a crucial step in many metabolic pathways. The facultative anaerobic mitochondrion of the photosynthetic protist Euglena gracilis oxidizes pyruvate with PNO. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as indolepyruvate or phenylpyruvate.
Pssm-ID: 132917 [Multi-domain] Cd Length: 160 Bit Score: 37.48 E-value: 6.46e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 16 GAKVIAQALKTQDVEYIFGIVGIPVTEIA-----IAAQQLGIKYIGMRNEQAA---CYAASAIGYLtsrpgVCLVVSGPG 87
Cdd:cd07034 1 GNEAVARGALAAGVDVVAAYPITPSTEIAetlakAVLGELGGVVVQAESEHAAaeaAIGASAAGAR-----AMTATSGPG 75
|
90 100
....*....|....*....|.
gi 93004078 88 LIHALGGMANANMNCWPLLVI 108
Cdd:cd07034 76 LNLMAEALYLAAGAELPLVIV 96
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|
| TPP_IOR_alpha |
cd02008 |
Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of ... |
403-483 |
6.84e-03 |
|
Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as indolepyruvate or phenylpyruvate, which are generated by the transamination of aromatic amino acids, to the corresponding aryl acetyl-CoA.
Pssm-ID: 238966 [Multi-domain] Cd Length: 178 Bit Score: 38.03 E-value: 6.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93004078 403 DIGRTVLQNYLPRHRLDagTFGTMGVGLGFAIAAAVVakdrSPGQWIICVEGDSAFGFSGME--VETIcrYN-LPIILLV 479
Cdd:cd02008 32 DIGCYTLGALPPLNAID--TCTCMGASIGVAIGMAKA----SEDKKVVAVIGDSTFFHSGILglINAV--YNkANITVVI 103
|
....
gi 93004078 480 VNNN 483
Cdd:cd02008 104 LDNR 107
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