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Conserved domains on  [gi|6912478|ref|NP_036448|]
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importin subunit alpha-7 [Homo sapiens]

Protein Classification

armadillo/beta-catenin-like repeat-containing protein( domain architecture ID 1000979)

armadillo/beta-catenin-like repeat-containing protein similar to Saccharomyces cerevisiae vacuolar protein 8 that functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SRP1 super family cl34886
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
36-525 0e+00

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5064:

Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 621.53  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912478   36 IQLRKQKREQQLFKRRNVELINEEAamfdsllMDSYVSSTTGESVITREMVEMLFSDDSDLQLATTQKFRKLLSKEPSPP 115
Cdd:COG5064  34 VELRKQKREELLNKRRNLADVSEEA-------ESSFIPMEQQFYSELPQLTQQLFSDDIEQQLQAVYKFRKLLSKETSPP 106

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912478  116 IDEVINTPrVVDRFVEFLKRNENCTLQFEAAWALTNIASGTSQQTKIVIEAGAVPIFIELLNSDFEDVQEQAVWALGNIA 195
Cdd:COG5064 107 IQPVIDAG-VVPRFVEFMDEIQRDMLQFEAAWALTNIASGTTQQTKVVVDAGAVPLFIQLLSSTEDDVREQAVWALGNIA 185

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912478  196 GDSSVCRDYVLNCSILNPLLTLLTKSTR-LTMTRNAVWALSNLCRGKNPPPEFAKVSPCLPVLSRLLFSSDSDLLADACW 274
Cdd:COG5064 186 GDSEGCRDYVLQCGALEPLLGLLLSSAIhISMLRNATWTLSNLCRGKNPPPDWSNISQALPILAKLIYSRDPEVLVDACW 265

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912478  275 ALSYLSDGPNEKIQAVIDSGVCRRLVELLMHNDYKVASPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRK 354
Cdd:COG5064 266 AISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSVGNIVTGSDDQTQVIINCGALKAFRSLLSSPKENIRK 345

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912478  355 EACWTISNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGT--PEQIRYLVSLGCIKPLCDLLTV 432
Cdd:COG5064 346 EACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEACWAISNATSGGLnrPDIIRYLVSQGFIKPLCDLLDV 425

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912478  433 MDSKIVQVALNGLENILRLGEQEGKRSGSGVNPYCGLIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGVEDDDSSLA 512
Cdd:COG5064 426 VDNKIIEVALDAIENILKVGEQDRLRYGKNINIYAVYVEKAGGMDAIHGLQDSVNRTIYDKAYSIIEKFFGEEDAVDELA 505

                       490       500
                ....*....|....*....|.
gi 6912478  513 PQV--------DETQQQFIFQ 525
Cdd:COG5064 506 PETagntftfgSNVNQQGNFN 526
 
Name Accession Description Interval E-value
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
36-525 0e+00

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 621.53  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912478   36 IQLRKQKREQQLFKRRNVELINEEAamfdsllMDSYVSSTTGESVITREMVEMLFSDDSDLQLATTQKFRKLLSKEPSPP 115
Cdd:COG5064  34 VELRKQKREELLNKRRNLADVSEEA-------ESSFIPMEQQFYSELPQLTQQLFSDDIEQQLQAVYKFRKLLSKETSPP 106

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912478  116 IDEVINTPrVVDRFVEFLKRNENCTLQFEAAWALTNIASGTSQQTKIVIEAGAVPIFIELLNSDFEDVQEQAVWALGNIA 195
Cdd:COG5064 107 IQPVIDAG-VVPRFVEFMDEIQRDMLQFEAAWALTNIASGTTQQTKVVVDAGAVPLFIQLLSSTEDDVREQAVWALGNIA 185

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912478  196 GDSSVCRDYVLNCSILNPLLTLLTKSTR-LTMTRNAVWALSNLCRGKNPPPEFAKVSPCLPVLSRLLFSSDSDLLADACW 274
Cdd:COG5064 186 GDSEGCRDYVLQCGALEPLLGLLLSSAIhISMLRNATWTLSNLCRGKNPPPDWSNISQALPILAKLIYSRDPEVLVDACW 265

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912478  275 ALSYLSDGPNEKIQAVIDSGVCRRLVELLMHNDYKVASPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRK 354
Cdd:COG5064 266 AISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSVGNIVTGSDDQTQVIINCGALKAFRSLLSSPKENIRK 345

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912478  355 EACWTISNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGT--PEQIRYLVSLGCIKPLCDLLTV 432
Cdd:COG5064 346 EACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEACWAISNATSGGLnrPDIIRYLVSQGFIKPLCDLLDV 425

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912478  433 MDSKIVQVALNGLENILRLGEQEGKRSGSGVNPYCGLIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGVEDDDSSLA 512
Cdd:COG5064 426 VDNKIIEVALDAIENILKVGEQDRLRYGKNINIYAVYVEKAGGMDAIHGLQDSVNRTIYDKAYSIIEKFFGEEDAVDELA 505

                       490       500
                ....*....|....*....|.
gi 6912478  513 PQV--------DETQQQFIFQ 525
Cdd:COG5064 506 PETagntftfgSNVNQQGNFN 526
Arm_3 pfam16186
Atypical Arm repeat; This atypical Arm repeat appears at the very C-terminus of eukaryotic ...
 469-514 2.54e-19

Atypical Arm repeat; This atypical Arm repeat appears at the very C-terminus of eukaryotic proteins such as importin subunit alpha-2, as the last of the repeating units.


Pssm-ID: 465050 [Multi-domain]  Cd Length: 49  Bit Score: 81.48  E-value: 2.54e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 6912478    469 LIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGVED--DDSSLAPQ 514
Cdd:pfam16186   2 LIEEAGGLDKIEALQNHENEEIYKKAYKIIEKYFSDEEeeDDENLAPE 49
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 156-195 6.41e-10

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 54.36  E-value: 6.41e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 6912478     156 TSQQTKIVIEAGAVPIFIELLNSDFEDVQEQAVWALGNIA 195
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 83-237 4.91e-03

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 40.09  E-value: 4.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912478     83 REMVEMLFSDDSDLQ------LATTQKFRKLLSKepSPPIDEVINTprvvdrfVEFLKRNENCTLQFEAAWALTNIASGT 156
Cdd:PLN03200  612 RTLIQLLSSSKEETQekaasvLADIFSSRQDLCE--SLATDEIINP-------CIKLLTNNTEAVATQSARALAALSRSI 682

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912478    157 SQQTKI-VIEAGAVPIFIELLNSDFEDVQEQAVWALGNIAGDSSVCRDyVLNCSILNPLLTLLTKSTrLTMTRNAVWALS 235
Cdd:PLN03200  683 KENRKVsYAAEDAIKPLIKLAKSSSIEVAEQAVCALANLLSDPEVAAE-ALAEDIILPLTRVLREGT-LEGKRNAARALA 760


                  ..
gi 6912478    236 NL 237
Cdd:PLN03200  761 QL 762
 
Name Accession Description Interval E-value
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
36-525 0e+00

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 621.53  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912478   36 IQLRKQKREQQLFKRRNVELINEEAamfdsllMDSYVSSTTGESVITREMVEMLFSDDSDLQLATTQKFRKLLSKEPSPP 115
Cdd:COG5064  34 VELRKQKREELLNKRRNLADVSEEA-------ESSFIPMEQQFYSELPQLTQQLFSDDIEQQLQAVYKFRKLLSKETSPP 106

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912478  116 IDEVINTPrVVDRFVEFLKRNENCTLQFEAAWALTNIASGTSQQTKIVIEAGAVPIFIELLNSDFEDVQEQAVWALGNIA 195
Cdd:COG5064 107 IQPVIDAG-VVPRFVEFMDEIQRDMLQFEAAWALTNIASGTTQQTKVVVDAGAVPLFIQLLSSTEDDVREQAVWALGNIA 185

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912478  196 GDSSVCRDYVLNCSILNPLLTLLTKSTR-LTMTRNAVWALSNLCRGKNPPPEFAKVSPCLPVLSRLLFSSDSDLLADACW 274
Cdd:COG5064 186 GDSEGCRDYVLQCGALEPLLGLLLSSAIhISMLRNATWTLSNLCRGKNPPPDWSNISQALPILAKLIYSRDPEVLVDACW 265

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912478  275 ALSYLSDGPNEKIQAVIDSGVCRRLVELLMHNDYKVASPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRK 354
Cdd:COG5064 266 AISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSVGNIVTGSDDQTQVIINCGALKAFRSLLSSPKENIRK 345

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912478  355 EACWTISNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGT--PEQIRYLVSLGCIKPLCDLLTV 432
Cdd:COG5064 346 EACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEACWAISNATSGGLnrPDIIRYLVSQGFIKPLCDLLDV 425

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912478  433 MDSKIVQVALNGLENILRLGEQEGKRSGSGVNPYCGLIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGVEDDDSSLA 512
Cdd:COG5064 426 VDNKIIEVALDAIENILKVGEQDRLRYGKNINIYAVYVEKAGGMDAIHGLQDSVNRTIYDKAYSIIEKFFGEEDAVDELA 505

                       490       500
                ....*....|....*....|.
gi 6912478  513 PQV--------DETQQQFIFQ 525
Cdd:COG5064 506 PETagntftfgSNVNQQGNFN 526
Arm_3 pfam16186
Atypical Arm repeat; This atypical Arm repeat appears at the very C-terminus of eukaryotic ...
 469-514 2.54e-19

Atypical Arm repeat; This atypical Arm repeat appears at the very C-terminus of eukaryotic proteins such as importin subunit alpha-2, as the last of the repeating units.


Pssm-ID: 465050 [Multi-domain]  Cd Length: 49  Bit Score: 81.48  E-value: 2.54e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 6912478    469 LIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGVED--DDSSLAPQ 514
Cdd:pfam16186   2 LIEEAGGLDKIEALQNHENEEIYKKAYKIIEKYFSDEEeeDDENLAPE 49
IBB pfam01749
Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), ...
 13-102 4.26e-18

Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), importin beta (karyopherin beta) binding domain. The domain mediates formation of the importin alpha beta complex; required for classical NLS import of proteins into the nucleus, through the nuclear pore complex and across the nuclear envelope. Also in the alignment is the NLS of importin alpha which overlaps with the IBB domain.


Pssm-ID: 460311 [Multi-domain]  Cd Length: 79  Bit Score: 78.73  E-value: 4.26e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912478     13 RMKSYKNNALNPEEMRRRREEEGIQLRKQKREQQLFKRRNVELINEEAAMFDSLLmdsyvssttgeSVITREMVEMLFSD 92
Cdd:pfam01749   1 RRKSFKNKGKDADELRRRREEVQVELRKQKREEQLLKRRNVGAPSSSSSSAESQL-----------LESLPEMVQGVNSD 69

                          90
                  ....*....|
gi 6912478     93 DSDLQLATTQ 102
Cdd:pfam01749  70 DPELQLEATQ 79
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 156-195 1.08e-11

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 59.39  E-value: 1.08e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 6912478    156 TSQQTKIVIEAGAVPIFIELLNSDFEDVQEQAVWALGNIA 195
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
HEAT COG1413
HEAT repeat [General function prediction only];
228-402 2.41e-11

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 61.57  E-value: 2.41e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912478  228 RNAVWALSNLcrgknpppefaKVSPCLPVLSRLLFSSDSDLLADACWALSYLSDgpnekIQAVidsgvcRRLVELLMHND 307
Cdd:COG1413   3 RAAARALGRL-----------GDPAAVPALIAALADEDPDVRAAAARALGRLGD-----PRAV------PALLEALKDPD 60

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912478  308 YKVASPALRAVGNIvtGDDiqtqvilncSALPCLLHLLSSPKESIRKEACWTISNITagnraqiqaviDANIFPVLIEIL 387
Cdd:COG1413  61 PEVRAAAAEALGRI--GDP---------EAVPALIAALKDEDPEVRRAAAEALGRLG-----------DPAAVPALLEAL 118

                       170
                ....*....|....*
gi 6912478  388 QKAEFRTRKEAAWAI 402
Cdd:COG1413 119 KDPDWEVRRAAARAL 133
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 328-365 3.50e-10

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 55.15  E-value: 3.50e-10
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 6912478    328 QTQVILNCSALPCLLHLLSSPKESIRKEACWTISNITA 365
Cdd:pfam00514   4 NKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 156-195 6.41e-10

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 54.36  E-value: 6.41e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 6912478     156 TSQQTKIVIEAGAVPIFIELLNSDFEDVQEQAVWALGNIA 195
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
HEAT COG1413
HEAT repeat [General function prediction only];
145-321 1.09e-09

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 56.56  E-value: 1.09e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912478  145 AAWALTNIASgtsqqtkivieAGAVPIFIELLNSDFEDVQEQAVWALGNIAGDSSVcrdyvlncsilNPLLTLLtKSTRL 224
Cdd:COG1413   5 AARALGRLGD-----------PAAVPALIAALADEDPDVRAAAARALGRLGDPRAV-----------PALLEAL-KDPDP 61

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912478  225 TMTRNAVWALSNLcrgKNPPPefakvspcLPVLSRLLFSSDSDLLADACWALSYLSDgpnekiQAVIDsgvcrRLVELLM 304
Cdd:COG1413  62 EVRAAAAEALGRI---GDPEA--------VPALIAALKDEDPEVRRAAAEALGRLGD------PAAVP-----ALLEALK 119

                       170
                ....*....|....*..
gi 6912478  305 HNDYKVASPALRAVGNI 321
Cdd:COG1413 120 DPDWEVRRAAARALGRL 136
HEAT COG1413
HEAT repeat [General function prediction only];
183-363 8.23e-09

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 54.25  E-value: 8.23e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912478  183 VQEQAVWALGNIAGDSSVcrdyvlncsilnPLLTLLTKSTRLTMTRNAVWALSNLcrgknpppefaKVSPCLPVLSRLLF 262
Cdd:COG1413   1 VRRAAARALGRLGDPAAV------------PALIAALADEDPDVRAAAARALGRL-----------GDPRAVPALLEALK 57

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912478  263 SSDSDLLADACWALSYLSDgpnekiQAVIDsgvcrRLVELLMHNDYKVASPALRAVGNIvtGDDiqtqvilncSALPCLL 342
Cdd:COG1413  58 DPDPEVRAAAAEALGRIGD------PEAVP-----ALIAALKDEDPEVRRAAAEALGRL--GDP---------AAVPALL 115

                       170       180
                ....*....|....*....|.
gi 6912478  343 HLLSSPKESIRKEACWTISNI 363
Cdd:COG1413 116 EALKDPDWEVRRAAARALGRL 136
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 325-365 3.41e-08

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 49.35  E-value: 3.41e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 6912478     325 DDIQTQVILNCSALPCLLHLLSSPKESIRKEACWTISNITA 365
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 141-194 4.42e-08

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 49.67  E-value: 4.42e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 6912478    141 LQFEAAWALTNIASGTSQQTKIVIEAgAVPIFIELLNSDFEDVQEQAVWALGNI 194
Cdd:pfam13513   3 VREAAALALGSLAEGGPDLLAPAVPE-LLPALLPLLNDDSDLVREAAAWALGRL 55
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 367-407 1.03e-07

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 48.22  E-value: 1.03e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 6912478    367 NRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATS 407
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 283-323 5.46e-07

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 45.91  E-value: 5.46e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 6912478    283 PNEKIQAVIDSGVCRRLVELLMHNDYKVASPALRAVGNIVT 323
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 410-450 7.93e-07

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 45.52  E-value: 7.93e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 6912478    410 TPEQIRYLVSLGCIKPLCDLLTVMDSKIVQVALNGLENILR 450
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 198-239 9.10e-07

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 45.52  E-value: 9.10e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 6912478    198 SSVCRDYVLNCSILNPLLTLLtKSTRLTMTRNAVWALSNLCR 239
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLL-SSPDEEVQEEAAWALSNLAA 41
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 126-235 4.11e-06

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 45.02  E-value: 4.11e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912478    126 VDRFVEFLKRNENCTLQFEAAWALTNIASgtsqqtkivieAGAVPIFIELLNSDFEDVQEQAVWALGNIaGDSSVcrdyv 205
Cdd:pfam13646   1 LPALLQALLRDPDPEVRAAAIRALGRIGD-----------PEAVPALLELLKDEDPAVRRAAAEALGKI-GDPEA----- 63

                          90       100       110
                  ....*....|....*....|....*....|
gi 6912478    206 lncsiLNPLLTLLTKSTRLTMTRNAVWALS 235
Cdd:pfam13646  64 -----LPALLELLRDDDDDVVRAAAAEALA 88
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 283-322 6.52e-06

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 43.19  E-value: 6.52e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 6912478     283 PNEKIQAVIDSGVCRRLVELLMHNDYKVASPALRAVGNIV 322
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 367-407 1.72e-05

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 42.03  E-value: 1.72e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 6912478     367 NRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATS 407
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 242-281 1.83e-05

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 41.67  E-value: 1.83e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 6912478    242 NPPPEFAKVSPCLPVLSRLLFSSDSDLLADACWALSYLSD 281
Cdd:pfam00514   2 PENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
HEAT COG1413
HEAT repeat [General function prediction only];
120-195 2.50e-05

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 44.23  E-value: 2.50e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6912478  120 INTPRVVDRFVEFLKrNENCTLQFEAAWALTNIASgtsqqtkivieAGAVPIFIELLNSDFEDVQEQAVWALGNIA 195
Cdd:COG1413  74 IGDPEAVPALIAALK-DEDPEVRRAAAEALGRLGD-----------PAAVPALLEALKDPDWEVRRAAARALGRLG 137
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 314-363 7.08e-05

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 40.43  E-value: 7.08e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 6912478    314 ALRAVGNI--VTGDDIQTQVIlncSALPCLLHLLSSPKESIRKEACWTISNI 363
Cdd:pfam13513   7 AALALGSLaeGGPDLLAPAVP---ELLPALLPLLNDDSDLVREAAAWALGRL 55
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 410-448 1.29e-04

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 39.33  E-value: 1.29e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 6912478     410 TPEQIRYLVSLGCIKPLCDLLTVMDSKIVQVALNGLENI 448
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNL 39
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 112-154 2.12e-04

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 38.97  E-value: 2.12e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 6912478    112 PSPPIDEVINtPRVVDRFVEFLKrNENCTLQFEAAWALTNIAS 154
Cdd:pfam00514   1 SPENKQAVIE-AGAVPPLVRLLS-SPDEEVQEEAAWALSNLAA 41
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 183-237 1.81e-03

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 36.58  E-value: 1.81e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 6912478    183 VQEQAVWALGNIA-GDSSVCRDYVLNcsILNPLLTLLTKSTRLTMtRNAVWALSNL 237
Cdd:pfam13513   3 VREAAALALGSLAeGGPDLLAPAVPE--LLPALLPLLNDDSDLVR-EAAAWALGRL 55
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 299-399 2.17e-03

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 37.32  E-value: 2.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912478    299 LVELLM-HNDYKVASPALRAVGNIvtGDDiqtqvilncSALPCLLHLLSSPKESIRKEACWTISNItaGNRAQIqavida 377
Cdd:pfam13646   4 LLQALLrDPDPEVRAAAIRALGRI--GDP---------EAVPALLELLKDEDPAVRRAAAEALGKI--GDPEAL------ 64

                          90       100
                  ....*....|....*....|..
gi 6912478    378 nifPVLIEILQKAEFRTRKEAA 399
Cdd:pfam13646  65 ---PALLELLRDDDDDVVRAAA 83
HEAT COG1413
HEAT repeat [General function prediction only];
310-448 4.80e-03

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 37.69  E-value: 4.80e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912478  310 VASPALRAVGNIvtGDDiqtqvilncSALPCLLHLLSSPKESIRKEACWTISNITagnraqiqaviDANIFPVLIEILQK 389
Cdd:COG1413   1 VRRAAARALGRL--GDP---------AAVPALIAALADEDPDVRAAAARALGRLG-----------DPRAVPALLEALKD 58

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 6912478  390 AEFRTRKEAAWAITNAtsgGTPEQirylvslgcIKPLCDLLTVMDSKIVQVALNGLENI 448
Cdd:COG1413  59 PDPEVRAAAAEALGRI---GDPEA---------VPALIAALKDEDPEVRRAAAEALGRL 105
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 83-237 4.91e-03

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 40.09  E-value: 4.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912478     83 REMVEMLFSDDSDLQ------LATTQKFRKLLSKepSPPIDEVINTprvvdrfVEFLKRNENCTLQFEAAWALTNIASGT 156
Cdd:PLN03200  612 RTLIQLLSSSKEETQekaasvLADIFSSRQDLCE--SLATDEIINP-------CIKLLTNNTEAVATQSARALAALSRSI 682

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912478    157 SQQTKI-VIEAGAVPIFIELLNSDFEDVQEQAVWALGNIAGDSSVCRDyVLNCSILNPLLTLLTKSTrLTMTRNAVWALS 235
Cdd:PLN03200  683 KENRKVsYAAEDAIKPLIKLAKSSSIEVAEQAVCALANLLSDPEVAAE-ALAEDIILPLTRVLREGT-LEGKRNAARALA 760


                  ..
gi 6912478    236 NL 237
Cdd:PLN03200  761 QL 762
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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