stromelysin-3 precursor [Rattus norvegicus]
M10A family metallopeptidase( domain architecture ID 11995186)
M10A family metallopeptidase similar to matrix metalloproteinases with a C-terminal hemopexin repeat-containing domain that may be endopeptidases that degrade various components of the extracellular matrix
List of domain hits
Name | Accession | Description | Interval | E-value | ||||
Peptidase_M10 | pfam00413 | Matrixin; The members of this family are enzymes that cleave peptides. These proteases require ... |
108-261 | 3.66e-79 | ||||
Matrixin; The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. : Pssm-ID: 425668 [Multi-domain] Cd Length: 159 Bit Score: 243.68 E-value: 3.66e-79
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HX | cd00094 | Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ... |
294-483 | 1.85e-66 | ||||
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat. : Pssm-ID: 238046 [Multi-domain] Cd Length: 194 Bit Score: 212.17 E-value: 1.85e-66
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Name | Accession | Description | Interval | E-value | ||||
Peptidase_M10 | pfam00413 | Matrixin; The members of this family are enzymes that cleave peptides. These proteases require ... |
108-261 | 3.66e-79 | ||||
Matrixin; The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Pssm-ID: 425668 [Multi-domain] Cd Length: 159 Bit Score: 243.68 E-value: 3.66e-79
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ZnMc_MMP | cd04278 | Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are ... |
108-261 | 1.29e-76 | ||||
Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate specification, cell migration, tissue repair, tumorigenesis, gain or loss of tissue-specific functions, and apoptosis. In many instances, they are anchored to cell membranes via trans-membrane domains, and their activity is controlled via TIMPs (tissue inhibitors of metalloproteinases). Pssm-ID: 239805 [Multi-domain] Cd Length: 157 Bit Score: 237.10 E-value: 1.29e-76
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HX | cd00094 | Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ... |
294-483 | 1.85e-66 | ||||
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat. Pssm-ID: 238046 [Multi-domain] Cd Length: 194 Bit Score: 212.17 E-value: 1.85e-66
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ZnMc | smart00235 | Zinc-dependent metalloprotease; Neutral zinc metallopeptidases. This alignment represents a ... |
108-261 | 6.38e-32 | ||||
Zinc-dependent metalloprotease; Neutral zinc metallopeptidases. This alignment represents a subset of known subfamilies. Highest similarity occurs in the HExxH zinc-binding site/ active site. Pssm-ID: 214576 [Multi-domain] Cd Length: 139 Bit Score: 118.99 E-value: 6.38e-32
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HX | smart00120 | Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ... |
301-344 | 1.91e-08 | ||||
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). Pssm-ID: 214524 [Multi-domain] Cd Length: 45 Bit Score: 50.32 E-value: 1.91e-08
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Hemopexin | pfam00045 | Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ... |
301-344 | 7.54e-08 | ||||
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs). Pssm-ID: 395000 [Multi-domain] Cd Length: 44 Bit Score: 48.33 E-value: 7.54e-08
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COG1913 | COG1913 | Predicted Zn-dependent protease [General function prediction only]; |
212-255 | 5.19e-03 | ||||
Predicted Zn-dependent protease [General function prediction only]; Pssm-ID: 441517 Cd Length: 175 Bit Score: 38.01 E-value: 5.19e-03
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Name | Accession | Description | Interval | E-value | ||||
Peptidase_M10 | pfam00413 | Matrixin; The members of this family are enzymes that cleave peptides. These proteases require ... |
108-261 | 3.66e-79 | ||||
Matrixin; The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Pssm-ID: 425668 [Multi-domain] Cd Length: 159 Bit Score: 243.68 E-value: 3.66e-79
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ZnMc_MMP | cd04278 | Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are ... |
108-261 | 1.29e-76 | ||||
Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate specification, cell migration, tissue repair, tumorigenesis, gain or loss of tissue-specific functions, and apoptosis. In many instances, they are anchored to cell membranes via trans-membrane domains, and their activity is controlled via TIMPs (tissue inhibitors of metalloproteinases). Pssm-ID: 239805 [Multi-domain] Cd Length: 157 Bit Score: 237.10 E-value: 1.29e-76
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HX | cd00094 | Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ... |
294-483 | 1.85e-66 | ||||
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat. Pssm-ID: 238046 [Multi-domain] Cd Length: 194 Bit Score: 212.17 E-value: 1.85e-66
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ZnMc | smart00235 | Zinc-dependent metalloprotease; Neutral zinc metallopeptidases. This alignment represents a ... |
108-261 | 6.38e-32 | ||||
Zinc-dependent metalloprotease; Neutral zinc metallopeptidases. This alignment represents a subset of known subfamilies. Highest similarity occurs in the HExxH zinc-binding site/ active site. Pssm-ID: 214576 [Multi-domain] Cd Length: 139 Bit Score: 118.99 E-value: 6.38e-32
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ZnMc_MMP_like_1 | cd04279 | Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and ... |
129-261 | 3.54e-16 | ||||
Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin. Pssm-ID: 239806 [Multi-domain] Cd Length: 156 Bit Score: 75.57 E-value: 3.54e-16
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ZnMc_serralysin_like | cd04277 | Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases ... |
121-261 | 3.57e-14 | ||||
Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not require n-terminal signal sequences which are cleaved after the transmembrane translocation. A calcium-binding domain c-terminal to the metalloprotease domain, which contains multiple tandem repeats of a nine-residue motif including the pattern GGxGxD, and which forms a parallel beta roll may be involved in the translocation mechanism and/or substrate binding. Serralysin family members may have a broad spectrum of substrates each, including host immunoglobulins, complement proteins, cell matrix and cytoskeletal proteins, as well as antimicrobial peptides. Pssm-ID: 239804 [Multi-domain] Cd Length: 186 Bit Score: 70.91 E-value: 3.57e-14
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ZnMc | cd00203 | Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major ... |
127-260 | 1.39e-13 | ||||
Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which are involved in vertebrate development and disease. Pssm-ID: 238124 [Multi-domain] Cd Length: 167 Bit Score: 68.70 E-value: 1.39e-13
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ZnMc_MMP_like | cd04268 | Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix ... |
111-260 | 1.96e-10 | ||||
Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases. Pssm-ID: 239796 [Multi-domain] Cd Length: 165 Bit Score: 59.43 E-value: 1.96e-10
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HX | smart00120 | Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ... |
301-344 | 1.91e-08 | ||||
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). Pssm-ID: 214524 [Multi-domain] Cd Length: 45 Bit Score: 50.32 E-value: 1.91e-08
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Hemopexin | pfam00045 | Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ... |
301-344 | 7.54e-08 | ||||
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs). Pssm-ID: 395000 [Multi-domain] Cd Length: 44 Bit Score: 48.33 E-value: 7.54e-08
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Hemopexin | pfam00045 | Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ... |
390-437 | 2.57e-07 | ||||
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs). Pssm-ID: 395000 [Multi-domain] Cd Length: 44 Bit Score: 47.18 E-value: 2.57e-07
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Hemopexin | pfam00045 | Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ... |
346-383 | 1.02e-06 | ||||
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs). Pssm-ID: 395000 [Multi-domain] Cd Length: 44 Bit Score: 45.25 E-value: 1.02e-06
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HX | smart00120 | Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ... |
439-481 | 1.77e-06 | ||||
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). Pssm-ID: 214524 [Multi-domain] Cd Length: 45 Bit Score: 44.54 E-value: 1.77e-06
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HX | smart00120 | Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ... |
390-437 | 4.08e-06 | ||||
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). Pssm-ID: 214524 [Multi-domain] Cd Length: 45 Bit Score: 43.77 E-value: 4.08e-06
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HX | smart00120 | Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ... |
346-383 | 2.30e-05 | ||||
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). Pssm-ID: 214524 [Multi-domain] Cd Length: 45 Bit Score: 41.46 E-value: 2.30e-05
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Hemopexin | pfam00045 | Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ... |
439-476 | 2.77e-05 | ||||
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs). Pssm-ID: 395000 [Multi-domain] Cd Length: 44 Bit Score: 41.40 E-value: 2.77e-05
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COG1913 | COG1913 | Predicted Zn-dependent protease [General function prediction only]; |
212-255 | 5.19e-03 | ||||
Predicted Zn-dependent protease [General function prediction only]; Pssm-ID: 441517 Cd Length: 175 Bit Score: 38.01 E-value: 5.19e-03
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ZnMc_MMP_like_2 | cd04276 | Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase ... |
212-241 | 8.68e-03 | ||||
Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin. Pssm-ID: 239803 Cd Length: 197 Bit Score: 37.69 E-value: 8.68e-03
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Blast search parameters | ||||
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