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Conserved domains on  [gi|7019381|ref|NP_037363|]
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leucine-rich repeat transmembrane protein FLRT2 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
50-310 1.02e-25

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 110.02  E-value: 1.02e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019381   50 NERSLTSVPLGIPEGVTVLYLHNNQINNAGFPAELHNVQSVHTVYLYGNQLDEFPMNLP--KNVRVLHLQENNIQTISrA 127
Cdd:COG4886  75 LLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEELAnlTNLKELDLSNNQLTDLP-E 153

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019381  128 ALAQLLKLEELHLDDNSISTVGVEdgaFREAISLKLLFLSKNHLSSVPVGL--PVDLQELRVDENRIAVISDmAFQNLTS 205
Cdd:COG4886 154 PLGNLTNLKSLDLSNNQLTDLPEE---LGNLTNLKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLTDLPE-PLANLTN 229

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019381  206 LERLIVDGNLLTNkgIAEgtFSHLTKLKEFSIVRNSLSHPPPDLPGTHLIRLYLQDNQINHIPLTAFSNLRKLERLDISN 285
Cdd:COG4886 230 LETLDLSNNQLTD--LPE--LGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLL 305

                       250       260
                ....*....|....*....|....*
gi 7019381  286 NQLRMLTQGVFDNLSNLKQLTARNN 310
Cdd:COG4886 306 LLLNLLELLILLLLLTTLLLLLLLL 330
PCC super family cl28216
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 282-359 1.13e-08

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


The actual alignment was detected with superfamily member TIGR00864:

Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 58.56  E-value: 1.13e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019381     282 DISNNQLRMLTQGVFDNLSNLKQLTARNNPWFCDCSIKWVTEWLKyiPSSLNVR---GFMCQGPEQVRGMAVreLNMNLL 358
Cdd:TIGR00864    1 DISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAE--EKGVKVRqpeAALCAGPGALAGQPL--LGIPLL 76


                   .
gi 7019381     359 S 359
Cdd:TIGR00864   77 D 77
fn3 pfam00041
Fibronectin type III domain;
426-494 1.29e-06

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 46.64  E-value: 1.29e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 7019381    426 QLSIHFVNDTSIQVSWLSLFT----VMAYKLTWVKMGHslvGGIVQERIVSGEKQHLSLVNLEPRSTYRICLV 494
Cdd:pfam00041   5 NLTVTDVTSTSLTVSWTPPPDgngpITGYEVEYRPKNS---GEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQ 74
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 35-62 3.95e-04

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


:

Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 37.99  E-value: 3.95e-04
                          10        20
                  ....*....|....*....|....*...
gi 7019381     35 ACPSVCRCDRNFVYCNERSLTSVPLGIP 62
Cdd:pfam01462   1 ACPVPCHCSATVVNCSDRGLTAVPRDLP 28
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
50-310 1.02e-25

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 110.02  E-value: 1.02e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019381   50 NERSLTSVPLGIPEGVTVLYLHNNQINNAGFPAELHNVQSVHTVYLYGNQLDEFPMNLP--KNVRVLHLQENNIQTISrA 127
Cdd:COG4886  75 LLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEELAnlTNLKELDLSNNQLTDLP-E 153

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019381  128 ALAQLLKLEELHLDDNSISTVGVEdgaFREAISLKLLFLSKNHLSSVPVGL--PVDLQELRVDENRIAVISDmAFQNLTS 205
Cdd:COG4886 154 PLGNLTNLKSLDLSNNQLTDLPEE---LGNLTNLKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLTDLPE-PLANLTN 229

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019381  206 LERLIVDGNLLTNkgIAEgtFSHLTKLKEFSIVRNSLSHPPPDLPGTHLIRLYLQDNQINHIPLTAFSNLRKLERLDISN 285
Cdd:COG4886 230 LETLDLSNNQLTD--LPE--LGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLL 305

                       250       260
                ....*....|....*....|....*
gi 7019381  286 NQLRMLTQGVFDNLSNLKQLTARNN 310
Cdd:COG4886 306 LLLNLLELLILLLLLTTLLLLLLLL 330
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
54-265 7.05e-16

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 81.67  E-value: 7.05e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019381    54 LTSVPLGIPEGVTVLYLHNNQINNagFPAELHNvqSVHTVYLYGNQLDEFPMNLPKNVRVLHLQENNIQTISR---AALA 130
Cdd:PRK15370 190 LTTIPACIPEQITTLILDNNELKS--LPENLQG--NIKTLYANSNQLTSIPATLPDTIQEMELSINRITELPErlpSALQ 265

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019381   131 QLL---------------KLEELHLDDNSISTVG-------VEDGAFREAIS---------LKLLFLSKNHLSSVPVGLP 179
Cdd:PRK15370 266 SLDlfhnkisclpenlpeELRYLSVYDNSIRTLPahlpsgiTHLNVQSNSLTalpetlppgLKTLEAGENALTSLPASLP 345

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019381   180 VDLQELRVDENRIAVISDMAFQNLTSLErliVDGNLLTNkgIAEGTFSHLtKLKEFSivRNSLSHPPPDLP-----GTHL 254
Cdd:PRK15370 346 PELQVLDVSKNQITVLPETLPPTITTLD---VSRNALTN--LPENLPAAL-QIMQAS--RNNLVRLPESLPhfrgeGPQP 417

                        250
                 ....*....|.
gi 7019381   255 IRLYLQDNQIN 265
Cdd:PRK15370 418 TRIIVEYNPFS 428
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 89-311 2.35e-15

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 75.59  E-value: 2.35e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019381   89 SVHTVYLYGNQLDEFP-MNLPKNVRVLHLQENNIQTISraALAQLLKLEELHLDDNSISTVGVEDGafreAISLKLLFLS 167
Cdd:cd21340   3 RITHLYLNDKNITKIDnLSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKIENLEN----LVNLKKLYLG 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019381  168 KNHLSSVpVGL--PVDLQELRVDEnriavisdmafQNLTSLERLIVDGNLLTNkgiaegtfshltklkefsiVRNSLSHp 245
Cdd:cd21340  77 GNRISVV-EGLenLTNLEELHIEN-----------QRLPPGEKLTFDPRSLAA-------------------LSNSLRV- 124

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 7019381  246 ppdlpgthlirLYLQDNQINHipLTAFSNLRKLERLDISNNQLRMLTQ--GVFDNLSNLKQLTARNNP 311
Cdd:cd21340 125 -----------LNISGNNIDS--LEPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNP 179
LRR_8 pfam13855
Leucine rich repeat;
252-311 2.60e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 56.38  E-value: 2.60e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019381    252 THLIRLYLQDNQINHIPLTAFSNLRKLERLDISNNQLRMLTQGVFDNLSNLKQLTARNNP 311
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 282-359 1.13e-08

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 58.56  E-value: 1.13e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019381     282 DISNNQLRMLTQGVFDNLSNLKQLTARNNPWFCDCSIKWVTEWLKyiPSSLNVR---GFMCQGPEQVRGMAVreLNMNLL 358
Cdd:TIGR00864    1 DISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAE--EKGVKVRqpeAALCAGPGALAGQPL--LGIPLL 76


                   .
gi 7019381     359 S 359
Cdd:TIGR00864   77 D 77
LRRCT smart00082
Leucine rich repeat C-terminal domain;
310-361 1.07e-06

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 45.88  E-value: 1.07e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 7019381     310 NPWFCDCSIKWVTEWL---KYIPSSLNVRgfmCQGPEQVRGmAVRELNMNLLSCP 361
Cdd:smart00082   1 NPFICDCELRWLLRWLqanEHLQDPVDLR---CASPSSLRG-PLLELLHSEFKCP 51
fn3 pfam00041
Fibronectin type III domain;
426-494 1.29e-06

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 46.64  E-value: 1.29e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 7019381    426 QLSIHFVNDTSIQVSWLSLFT----VMAYKLTWVKMGHslvGGIVQERIVSGEKQHLSLVNLEPRSTYRICLV 494
Cdd:pfam00041   5 NLTVTDVTSTSLTVSWTPPPDgngpITGYEVEYRPKNS---GEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQ 74
LRRNT smart00013
Leucine rich repeat N-terminal domain;
35-66 2.95e-04

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 38.45  E-value: 2.95e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 7019381      35 ACPSVCRCDRNFVYCNERSLTSVPLGIPEGVT 66
Cdd:smart00013   1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 35-62 3.95e-04

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 37.99  E-value: 3.95e-04
                          10        20
                  ....*....|....*....|....*...
gi 7019381     35 ACPSVCRCDRNFVYCNERSLTSVPLGIP 62
Cdd:pfam01462   1 ACPVPCHCSATVVNCSDRGLTAVPRDLP 28
LRRCT pfam01463
Leucine rich repeat C-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 336-361 9.20e-03

Leucine rich repeat C-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the C-terminus of tandem leucine rich repeats.


Pssm-ID: 279765  Cd Length: 26  Bit Score: 33.95  E-value: 9.20e-03
                          10        20
                  ....*....|....*....|....*.
gi 7019381    336 GFMCQGPEQVRGMAVRELNMNLLSCP 361
Cdd:pfam01463   1 NARCASPPRLRGQPLLDLLPSDFSCS 26
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
50-310 1.02e-25

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 110.02  E-value: 1.02e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019381   50 NERSLTSVPLGIPEGVTVLYLHNNQINNAGFPAELHNVQSVHTVYLYGNQLDEFPMNLP--KNVRVLHLQENNIQTISrA 127
Cdd:COG4886  75 LLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEELAnlTNLKELDLSNNQLTDLP-E 153

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019381  128 ALAQLLKLEELHLDDNSISTVGVEdgaFREAISLKLLFLSKNHLSSVPVGL--PVDLQELRVDENRIAVISDmAFQNLTS 205
Cdd:COG4886 154 PLGNLTNLKSLDLSNNQLTDLPEE---LGNLTNLKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLTDLPE-PLANLTN 229

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019381  206 LERLIVDGNLLTNkgIAEgtFSHLTKLKEFSIVRNSLSHPPPDLPGTHLIRLYLQDNQINHIPLTAFSNLRKLERLDISN 285
Cdd:COG4886 230 LETLDLSNNQLTD--LPE--LGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLL 305

                       250       260
                ....*....|....*....|....*
gi 7019381  286 NQLRMLTQGVFDNLSNLKQLTARNN 310
Cdd:COG4886 306 LLLNLLELLILLLLLTTLLLLLLLL 330
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
48-313 1.96e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.90  E-value: 1.96e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019381   48 YCNERSLTSVPLGIPE--GVTVLYLHNNQINNagFPAELHNVQSVHTVYLYGNQLDEFPMNL--PKNVRVLHLQENNIQT 123
Cdd:COG4886 142 DLSNNQLTDLPEPLGNltNLKSLDLSNNQLTD--LPEELGNLTNLKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLTD 219

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019381  124 ISrAALAQLLKLEELHLDDNSISTVGvedgAFREAISLKLLFLSKNHLSSVPVGLPVD-LQELRVDENRIAVISDMAFQN 202
Cdd:COG4886 220 LP-EPLANLTNLETLDLSNNQLTDLP----ELGNLTNLEELDLSNNQLTDLPPLANLTnLKTLDLSNNQLTDLKLKELEL 294

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019381  203 LTSLERLIVDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSLSHPPPDLPGTHLIRLYLQDNQINHIPLTAFSNLRKLERLD 282
Cdd:COG4886 295 LLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGL 374

                       250       260       270
                ....*....|....*....|....*....|.
gi 7019381  283 ISNNQLRMLTQGVFDNLSNLKQLTARNNPWF 313
Cdd:COG4886 375 LEATLLTLALLLLTLLLLLLTTTAGVLLLTL 405
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
54-265 7.05e-16

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 81.67  E-value: 7.05e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019381    54 LTSVPLGIPEGVTVLYLHNNQINNagFPAELHNvqSVHTVYLYGNQLDEFPMNLPKNVRVLHLQENNIQTISR---AALA 130
Cdd:PRK15370 190 LTTIPACIPEQITTLILDNNELKS--LPENLQG--NIKTLYANSNQLTSIPATLPDTIQEMELSINRITELPErlpSALQ 265

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019381   131 QLL---------------KLEELHLDDNSISTVG-------VEDGAFREAIS---------LKLLFLSKNHLSSVPVGLP 179
Cdd:PRK15370 266 SLDlfhnkisclpenlpeELRYLSVYDNSIRTLPahlpsgiTHLNVQSNSLTalpetlppgLKTLEAGENALTSLPASLP 345

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019381   180 VDLQELRVDENRIAVISDMAFQNLTSLErliVDGNLLTNkgIAEGTFSHLtKLKEFSivRNSLSHPPPDLP-----GTHL 254
Cdd:PRK15370 346 PELQVLDVSKNQITVLPETLPPTITTLD---VSRNALTN--LPENLPAAL-QIMQAS--RNNLVRLPESLPhfrgeGPQP 417

                        250
                 ....*....|.
gi 7019381   255 IRLYLQDNQIN 265
Cdd:PRK15370 418 TRIIVEYNPFS 428
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 89-311 2.35e-15

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 75.59  E-value: 2.35e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019381   89 SVHTVYLYGNQLDEFP-MNLPKNVRVLHLQENNIQTISraALAQLLKLEELHLDDNSISTVGVEDGafreAISLKLLFLS 167
Cdd:cd21340   3 RITHLYLNDKNITKIDnLSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKIENLEN----LVNLKKLYLG 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019381  168 KNHLSSVpVGL--PVDLQELRVDEnriavisdmafQNLTSLERLIVDGNLLTNkgiaegtfshltklkefsiVRNSLSHp 245
Cdd:cd21340  77 GNRISVV-EGLenLTNLEELHIEN-----------QRLPPGEKLTFDPRSLAA-------------------LSNSLRV- 124

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 7019381  246 ppdlpgthlirLYLQDNQINHipLTAFSNLRKLERLDISNNQLRMLTQ--GVFDNLSNLKQLTARNNP 311
Cdd:cd21340 125 -----------LNISGNNIDS--LEPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNP 179
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
105-310 9.52e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 76.90  E-value: 9.52e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019381  105 MNLPKNVRVLHLQENNIQTISRAALAQLLKLEELHLDDNSISTVGVEDGAFREAISLKLLFLSKNHLSSVPVGLPVDLQE 184
Cdd:COG4886  15 LLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGD 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019381  185 LRVDEnRIAVISDMAFQNLTSLERLIVDGNLLTNKGIAegtFSHLTKLKEFSIVRNSLSHPPPDLPG-THLIRLYLQDNQ 263
Cdd:COG4886  95 LTNLT-ELDLSGNEELSNLTNLESLDLSGNQLTDLPEE---LANLTNLKELDLSNNQLTDLPEPLGNlTNLKSLDLSNNQ 170

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 7019381  264 INHIPlTAFSNLRKLERLDISNNQLRMLTQgVFDNLSNLKQLTARNN 310
Cdd:COG4886 171 LTDLP-EELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGN 215
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 47-246 3.16e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 69.43  E-value: 3.16e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019381   47 VYCNERSLTSVP-LGIPEGVTVLYLHNNQINNAgfpAELHNVQSVHTVYLYGNQLDEFPM--NLpKNVRVLHLQENNIQT 123
Cdd:cd21340   7 LYLNDKNITKIDnLSLCKNLKVLYLYDNKITKI---ENLEFLTNLTHLYLQNNQIEKIENleNL-VNLKKLYLGGNRISV 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019381  124 ISraALAQLLKLEELHL-------------DDNSISTVgvedgafreAISLKLLFLSKNHLSsvpvglpvDLQELrvden 190
Cdd:cd21340  83 VE--GLENLTNLEELHIenqrlppgekltfDPRSLAAL---------SNSLRVLNISGNNID--------SLEPL----- 138

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 7019381  191 riavisdmafQNLTSLERLIVDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSLSHPP 246
Cdd:cd21340 139 ----------APLRNLEQLDASNNQISDLEELLDLLSSWPSLRELDLTGNPVCKKP 184
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
200-311 4.12e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.42  E-value: 4.12e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019381  200 FQNLTSLERLIVDGNLltnkgiaegTFSHLTKLKEFSIVRNSLSHPPPDLPG-THLIRLYLQDNQINHIPlTAFSNLRKL 278
Cdd:COG4886  92 LGDLTNLTELDLSGNE---------ELSNLTNLESLDLSGNQLTDLPEELANlTNLKELDLSNNQLTDLP-EPLGNLTNL 161

                        90       100       110
                ....*....|....*....|....*....|...
gi 7019381  279 ERLDISNNQLRMLTQgVFDNLSNLKQLTARNNP 311
Cdd:COG4886 162 KSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQ 193
LRR_8 pfam13855
Leucine rich repeat;
252-311 2.60e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 56.38  E-value: 2.60e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019381    252 THLIRLYLQDNQINHIPLTAFSNLRKLERLDISNNQLRMLTQGVFDNLSNLKQLTARNNP 311
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 65-223 2.86e-10

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 62.89  E-value: 2.86e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019381   65 VTVLYLHNNQINNAGFPA---ELHNVQSVHTVYLYGNQLDEFPMNL-------PKNVRVLHLQENNIQTISRAALAQLLK 134
Cdd:COG5238 238 LTTLDLSNNQIGDEGVIAlaeALKNNTTVETLYLSGNQIGAEGAIAlakalqgNTTLTSLDLSVNRIGDEGAIALAEGLQ 317

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019381  135 ----LEELHLDDNSISTVGVEdgAFREAI----SLKLLFLSKNHLSsvpvglpvdlqelrvDENRIAVISdmAFQNLTSL 206
Cdd:COG5238 318 gnktLHTLNLAYNGIGAQGAI--ALAKALqentTLHSLDLSDNQIG---------------DEGAIALAK--YLEGNTTL 378

                       170
                ....*....|....*..
gi 7019381  207 ERLIVDGNLLTNKGIAE 223
Cdd:COG5238 379 RELNLGKNNIGKQGAEA 395
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 110-289 5.22e-09

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 58.14  E-value: 5.22e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019381  110 NVRVLHLQENNIQTISRAALAQLLK----LEELHLDDN----SISTVGVEDGAFREAISLKLLFLSKNHLSSVPVGL--- 178
Cdd:cd00116  24 CLQVLRLEGNTLGEEAAKALASALRpqpsLKELCLSLNetgrIPRGLQSLLQGLTKGCGLQELDLSDNALGPDGCGVles 103

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019381  179 ---PVDLQELRVDENRIAvisDMAFQNLT--------SLERLIVDGNLLTNKGIAE--GTFSHLTKLKEFSIVRNSLSHP 245
Cdd:cd00116 104 llrSSSLQELKLNNNGLG---DRGLRLLAkglkdlppALEKLVLGRNRLEGASCEAlaKALRANRDLKELNLANNGIGDA 180

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 7019381  246 -----PPDLPG-THLIRLYLQDNQINHIPLTA----FSNLRKLERLDISNNQLR 289
Cdd:cd00116 181 giralAEGLKAnCNLEVLDLNNNGLTDEGASAlaetLASLKSLEVLNLGDNNLT 234
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 282-359 1.13e-08

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 58.56  E-value: 1.13e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019381     282 DISNNQLRMLTQGVFDNLSNLKQLTARNNPWFCDCSIKWVTEWLKyiPSSLNVR---GFMCQGPEQVRGMAVreLNMNLL 358
Cdd:TIGR00864    1 DISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAE--EKGVKVRqpeAALCAGPGALAGQPL--LGIPLL 76


                   .
gi 7019381     359 S 359
Cdd:TIGR00864   77 D 77
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
23-268 5.67e-08

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 55.94  E-value: 5.67e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019381    23 SLGLYSQVSKLLACPSVCRCDRNfvyCNERSLTSVPLGIPEGVTVLYLHNNQINN-AGFPAELHnvqsvhTVYLYGNQLD 101
Cdd:PRK15387 185 SRGRAAVVQKMRACLNNGNAVLN---VGESGLTTLPDCLPAHITTLVIPDNNLTSlPALPPELR------TLEVSGNQLT 255

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019381   102 EFPMnLPKNVRVLHLQENNIQTISR--AALAQLL--------------KLEELHLDDNSISTVgvedgafrEAISLKL-- 163
Cdd:PRK15387 256 SLPV-LPPGLLELSIFSNPLTHLPAlpSGLCKLWifgnqltslpvlppGLQELSVSDNQLASL--------PALPSELck 326

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019381   164 LFLSKNHLSSVPVgLPVDLQELRVDENRIAVISDM--------AFQN-LTS-------LERLIVDGNLLTNKGIAEgtfs 227
Cdd:PRK15387 327 LWAYNNQLTSLPT-LPSGLQELSVSDNQLASLPTLpselyklwAYNNrLTSlpalpsgLKELIVSGNRLTSLPVLP---- 401

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 7019381   228 hlTKLKEFSIVRNSLSHPPPdLPgTHLIRLYLQDNQINHIP 268
Cdd:PRK15387 402 --SELKELMVSGNRLTSLPM-LP-SGLLSLSVYRNQLTRLP 438
LRR_8 pfam13855
Leucine rich repeat;
204-288 1.31e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.67  E-value: 1.31e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019381    204 TSLERLIVDGNLLTNkgIAEGTFSHLTKLKEfsivrnslshpppdlpgthlirLYLQDNQINHIPLTAFSNLRKLERLDI 283
Cdd:pfam13855   1 PNLRSLDLSNNRLTS--LDDGAFKGLSNLKV----------------------LDLSNNLLTTLSPGAFSGLPSLRYLDL 56


                  ....*
gi 7019381    284 SNNQL 288
Cdd:pfam13855  57 SGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
182-242 4.30e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.13  E-value: 4.30e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 7019381    182 LQELRVDENRIAVISDMAFQNLTSLERLIVDGNLLTnkGIAEGTFSHLTKLKEFSIVRNSL 242
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLT--TLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
110-171 9.24e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.36  E-value: 9.24e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 7019381    110 NVRVLHLQENNIQTISRAALAQLLKLEELHLDDNSISTvgVEDGAFREAISLKLLFLSKNHL 171
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT--LSPGAFSGLPSLRYLDLSGNRL 61
LRRCT smart00082
Leucine rich repeat C-terminal domain;
310-361 1.07e-06

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 45.88  E-value: 1.07e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 7019381     310 NPWFCDCSIKWVTEWL---KYIPSSLNVRgfmCQGPEQVRGmAVRELNMNLLSCP 361
Cdd:smart00082   1 NPFICDCELRWLLRWLqanEHLQDPVDLR---CASPSSLRG-PLLELLHSEFKCP 51
fn3 pfam00041
Fibronectin type III domain;
426-494 1.29e-06

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 46.64  E-value: 1.29e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 7019381    426 QLSIHFVNDTSIQVSWLSLFT----VMAYKLTWVKMGHslvGGIVQERIVSGEKQHLSLVNLEPRSTYRICLV 494
Cdd:pfam00041   5 NLTVTDVTSTSLTVSWTPPPDgngpITGYEVEYRPKNS---GEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQ 74
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 52-192 2.24e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 50.05  E-value: 2.24e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019381   52 RSLTSVPlgipEGVTVLYLHNNQINNAGFPA---ELHNVQSVHTVYLYGNQLDE---------FPMNlpKNVRVLHLQEN 119
Cdd:cd00116 130 KGLKDLP----PALEKLVLGRNRLEGASCEAlakALRANRDLKELNLANNGIGDagiralaegLKAN--CNLEVLDLNNN 203

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019381  120 -----NIQTISrAALAQLLKLEELHLDDNSISTVGVE---DGAFREAISLKLLFLSKNHLSSVPV-----GLP--VDLQE 184
Cdd:cd00116 204 gltdeGASALA-ETLASLKSLEVLNLGDNNLTDAGAAalaSALLSPNISLLTLSLSCNDITDDGAkdlaeVLAekESLLE 282


                ....*...
gi 7019381  185 LRVDENRI 192
Cdd:cd00116 283 LDLRGNKF 290
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 129-310 2.68e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 49.66  E-value: 2.68e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019381  129 LAQLLKLEELHLDDNSISTVGVEdgAFREAI----SLKLLFLSKNHLSSVPVGL---------PVDLQELRVDENRIAVI 195
Cdd:cd00116  19 LPKLLCLQVLRLEGNTLGEEAAK--ALASALrpqpSLKELCLSLNETGRIPRGLqsllqgltkGCGLQELDLSDNALGPD 96

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019381  196 SDMAFQNLTSLERLivdGNL-LTNKGIAEGTFSHLTKlkefsivrnSLSHPPPDLPgthliRLYLQDNQINHIPLT---- 270
Cdd:cd00116  97 GCGVLESLLRSSSL---QELkLNNNGLGDRGLRLLAK---------GLKDLPPALE-----KLVLGRNRLEGASCEalak 159

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 7019381  271 AFSNLRKLERLDISNNQL-----RMLTQGVFDNlSNLKQLTARNN 310
Cdd:cd00116 160 ALRANRDLKELNLANNGIgdagiRALAEGLKAN-CNLEVLDLNNN 203
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 53-288 4.13e-06

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 49.79  E-value: 4.13e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019381   53 SLTSVPLGIPEGVTVLYLHNNQINNAGFPAELHNVQSVHTVYLYGNQLDEFP-------MNLPKNVRVLHLQENNIQTIS 125
Cdd:COG5238 145 QVLKDPLGGNAVHLLGLAARLGLLAAISMAKALQNNSVETVYLGCNQIGDEGieelaeaLTQNTTVTTLWLKRNPIGDEG 224

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019381  126 RAALAQLLK----LEELHLDDNSISTVGVEdgAFREAI----SLKLLFLSKNHLSsvpvglpvdlqelrvDENRIAVISd 197
Cdd:COG5238 225 AEILAEALKgnksLTTLDLSNNQIGDEGVI--ALAEALknntTVETLYLSGNQIG---------------AEGAIALAK- 286

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019381  198 mAFQNLTSLERLIVDGNLLTNKG---IAEGtfshltklkefsivrnslshpppdLPGTHLIR-LYLQDNQINH---IPL- 269
Cdd:COG5238 287 -ALQGNTTLTSLDLSVNRIGDEGaiaLAEG------------------------LQGNKTLHtLNLAYNGIGAqgaIALa 341

                       250
                ....*....|....*....
gi 7019381  270 TAFSNLRKLERLDISNNQL 288
Cdd:COG5238 342 KALQENTTLHSLDLSDNQI 360
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 81-288 5.20e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 49.85  E-value: 5.20e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019381    81 PAELHNVQSVHTVYLYGNQL-DEFPMNL--PKNVRVLHLQENNIQTISRAALAQLLKLEELHLDDNSIStvGVEDGAFRE 157
Cdd:PLN00113 253 PSSLGNLKNLQYLFLYQNKLsGPIPPSIfsLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFT--GKIPVALTS 330

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019381   158 AISLKLLFLSKNHLSSvpvGLPVDLQElrvdENRIAVIsDMAFQNLTSlerLIVDGnlLTNKGiaegtfsHLTKLKEFSi 237
Cdd:PLN00113 331 LPRLQVLQLWSNKFSG---EIPKNLGK----HNNLTVL-DLSTNNLTG---EIPEG--LCSSG-------NLFKLILFS- 389

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 7019381   238 vrNSL-SHPPPDLPGTH-LIRLYLQDNQINHIPLTAFSNLRKLERLDISNNQL 288
Cdd:PLN00113 390 --NSLeGEIPKSLGACRsLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNL 440
LRR_8 pfam13855
Leucine rich repeat;
134-216 8.49e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.67  E-value: 8.49e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019381    134 KLEELHLDDNSIStvGVEDGAFREAISLKLLFLSKNHLSSvpvglpvdlqelrvdenriavISDMAFQNLTSLERLIVDG 213
Cdd:pfam13855   2 NLRSLDLSNNRLT--SLDDGAFKGLSNLKVLDLSNNLLTT---------------------LSPGAFSGLPSLRYLDLSG 58


                  ...
gi 7019381    214 NLL 216
Cdd:pfam13855  59 NRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
47-206 1.83e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 48.15  E-value: 1.83e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019381    47 VYCNerSLTSVPLGIPEGVTVLYLHNNQINnaGFPAELHnvQSVHTVYLYGNQLDEFPMNLPKNVRVLHLQENNIqtisr 126
Cdd:PRK15370 290 VYDN--SIRTLPAHLPSGITHLNVQSNSLT--ALPETLP--PGLKTLEAGENALTSLPASLPPELQVLDVSKNQI----- 358

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019381   127 AALAQLL--KLEELHLDDNSISTVGVEDGAfreaiSLKLLFLSKNHLSSVPVGLPVDLQElRVDENRIAV----ISDMAF 200
Cdd:PRK15370 359 TVLPETLppTITTLDVSRNALTNLPENLPA-----ALQIMQASRNNLVRLPESLPHFRGE-GPQPTRIIVeynpFSERTI 432


                 ....*.
gi 7019381   201 QNLTSL 206
Cdd:PRK15370 433 QNMQRL 438
LRR_8 pfam13855
Leucine rich repeat;
88-145 1.23e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.20  E-value: 1.23e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 7019381     88 QSVHTVYLYGNQL----DEFPMNLPkNVRVLHLQENNIQTISRAALAQLLKLEELHLDDNSI 145
Cdd:pfam13855   1 PNLRSLDLSNNRLtsldDGAFKGLS-NLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 59-309 1.68e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.84  E-value: 1.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019381    59 LGIPEGVTVLYLHNNQINNAgFPAELHNVQSVHTVYLYGNQLD-EFPMNLP--KNVRVLHLQENNIQTISRAALAQLLKL 135
Cdd:PLN00113 352 LGKHNNLTVLDLSTNNLTGE-IPEGLCSSGNLFKLILFSNSLEgEIPKSLGacRSLRRVRLQDNSFSGELPSEFTKLPLV 430

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019381   136 EELHLDDNSIStvGVEDGAFREAISLKLLFLSKNHLSSvpvGLP-----VDLQELRVDENRIAVISDMAFQNLTSLERLI 210
Cdd:PLN00113 431 YFLDISNNNLQ--GRINSRKWDMPSLQMLSLARNKFFG---GLPdsfgsKRLENLDLSRNQFSGAVPRKLGSLSELMQLK 505

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019381   211 VDGNLLTNKgIAEgtfshltklkEFSIVRNslshpppdlpgthLIRLYLQDNQIN-HIPLTaFSNLRKLERLDISNNQlr 289
Cdd:PLN00113 506 LSENKLSGE-IPD----------ELSSCKK-------------LVSLDLSHNQLSgQIPAS-FSEMPVLSQLDLSQNQ-- 558

                        250       260
                 ....*....|....*....|
gi 7019381   290 mLTQGVFDNLSNLKQLTARN 309
Cdd:PLN00113 559 -LSGEIPKNLGNVESLVQVN 577
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 112-242 2.77e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.50  E-value: 2.77e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019381  112 RVLHLQENNI-----QTISRAALAQLLKLEELHLDDNSISTVGVED--GAFREAISLKLLFLSKNHLS-----SVPVGLP 179
Cdd:cd00116 111 QELKLNNNGLgdrglRLLAKGLKDLPPALEKLVLGRNRLEGASCEAlaKALRANRDLKELNLANNGIGdagirALAEGLK 190

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 7019381  180 VD--LQELRVDENRI----AVISDMAFQNLTSLERLIVDGNLLTNKGIAE---GTFSHLTKLKEFSIVRNSL 242
Cdd:cd00116 191 ANcnLEVLDLNNNGLtdegASALAETLASLKSLEVLNLGDNNLTDAGAAAlasALLSPNISLLTLSLSCNDI 262
LRRNT smart00013
Leucine rich repeat N-terminal domain;
35-66 2.95e-04

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 38.45  E-value: 2.95e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 7019381      35 ACPSVCRCDRNFVYCNERSLTSVPLGIPEGVT 66
Cdd:smart00013   1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 35-62 3.95e-04

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 37.99  E-value: 3.95e-04
                          10        20
                  ....*....|....*....|....*...
gi 7019381     35 ACPSVCRCDRNFVYCNERSLTSVPLGIP 62
Cdd:pfam01462   1 ACPVPCHCSATVVNCSDRGLTAVPRDLP 28
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 111-288 7.42e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.91  E-value: 7.42e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019381   111 VRVLHLQENNIQTISRAALAQLLKLEELHLDDNSISTvGVEDGAFREAISLKLLFLSKNHLS-SVPVGLPVDLQELRVDE 189
Cdd:PLN00113  71 VVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSG-PIPDDIFTTSSSLRYLNLSNNNFTgSIPRGSIPNLETLDLSN 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019381   190 N--------RIAVISDMAF----------------QNLTSLERLIVDGNLLTN------------KGIAEG--------- 224
Cdd:PLN00113 150 NmlsgeipnDIGSFSSLKVldlggnvlvgkipnslTNLTSLEFLTLASNQLVGqiprelgqmkslKWIYLGynnlsgeip 229

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 7019381   225 -TFSHLTKLKEFSIVRNSLSHPPP----DLPGTHLIRLYlQDNQINHIPLTAFSnLRKLERLDISNNQL 288
Cdd:PLN00113 230 yEIGGLTSLNHLDLVYNNLTGPIPsslgNLKNLQYLFLY-QNKLSGPIPPSIFS-LQKLISLDLSDNSL 296
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 195-306 9.92e-04

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 39.45  E-value: 9.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019381    195 ISDMAFQNlTSLERLIVDGNLLTnkgIAEGTFSHLTKLKEFSIvrnslshpPPDLP--------GTHLIRLYLQDNqINH 266
Cdd:pfam13306   3 IGSYAFYN-CSLTSITIPSSLTS---IGEYAFSNCTSLKSITL--------PSSLTsigsyafyNCSLTSITIPSS-LTS 69

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 7019381    267 IPLTAFSNLRKLERLDISNNqLRMLTQGVFDNlSNLKQLT 306
Cdd:pfam13306  70 IGEYAFSNCSNLKSITLPSN-LTSIGSYAFSN-CSLKSIT 107
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 65-145 1.43e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 41.70  E-value: 1.43e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019381   65 VTVLYLHNNQINNAGFPAELHNVQ---SVHTVYLYGNQLD--------EFPMNLPkNVRVLHLQENNIQTISRAALAQLL 133
Cdd:COG5238 322 LHTLNLAYNGIGAQGAIALAKALQentTLHSLDLSDNQIGdegaialaKYLEGNT-TLRELNLGKNNIGKQGAEALIDAL 400

                        90
                ....*....|....*
gi 7019381  134 KLEELH---LDDNSI 145
Cdd:COG5238 401 QTNRLHtliLDGNLI 415
LRRCT pfam01463
Leucine rich repeat C-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 336-361 9.20e-03

Leucine rich repeat C-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the C-terminus of tandem leucine rich repeats.


Pssm-ID: 279765  Cd Length: 26  Bit Score: 33.95  E-value: 9.20e-03
                          10        20
                  ....*....|....*....|....*.
gi 7019381    336 GFMCQGPEQVRGMAVRELNMNLLSCP 361
Cdd:pfam01463   1 NARCASPPRLRGQPLLDLLPSDFSCS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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