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Conserved domains on  [gi|19557645|ref|NP_037375|]
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secretogranin-3 isoform 1 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
SGIII super family cl21284
Secretogranin-3; Secretogranin_3 is a family of vertebrate proteins that is one of the granin ...
17-468 0e+00

Secretogranin-3; Secretogranin_3 is a family of vertebrate proteins that is one of the granin family. Granins are rich in acidic amino acids, exhibit aggregation at low pH, and possess a high capacity for calcium binding. Because granins are restricted in their localization to secretory granules of neuroendocrine cells, two interesting characteriztics of their sorting mechanisms have been observed. These are, first, that they aggregate on low pH/high calcium concentrations and second that two of them carry an N-terminal disulfide loop, mutations in which lead to mis-sorting. Thus, granins are thought to be essential for the sorting of secretory proteins at the trans-Golgi network. Chromogranin A (CgA) binds to SGIII in secretory granules of endocrine cells. SGIII directly binds to cholesterol components of the secretory granule membrane and targets CgA to secretory granules in pituitary and pancreatic endocrine cells. Mutations in the SGIII gene may influence the risk of obesity through possible regulation of hypothalamic neuropeptide secretion.


The actual alignment was detected with superfamily member pfam15467:

Pssm-ID: 464732  Cd Length: 449  Bit Score: 696.91  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19557645    17 IQAFPKPGGSQDKSLHNRELSAERPLNEQIAEAeeDKIKKTYPPENKPGQSNYSFVDNLNLLKAITEKEKiEKERQSIRS 96
Cdd:pfam15467   1 VSAFPTPGGSDDKAVYNRELSEERPLQEQIAEA--DSVKKSASKENPAASKNYSDADDLTLLKSLAEKQK-EKESASVRS 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19557645    97 SPLDNKLNVEDVDSTKNRKLIDDYDSTKSGLDHKFQDDPDGLHQLDGTPLTAEDIVHKIAARIYEENDRAVFDKIVSKLL 176
Cdd:pfam15467  78 KSGDDQYVPDDSDSTKNRRLADDYDSTKNGMDYKYQDDPDGLRQLDGTPLTAEDIVQKIATRIYEEDDRGVFDRIVSKLL 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19557645   177 NLGLITESQAHTLEDEVAEVLQKLISKEANNYE---EDPNKPTSWTE-NQAGKIPEKVTPMAAIQDGLAKGEN-DETVSN 251
Cdd:pfam15467 158 KLGLITESQADTLEYEVAEALQDLITKNAKNNEiedEDLDYPASRTEqDDAGKDEEKMEPPKPRQDEEDEEENeDDTVDN 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19557645   252 TLTLTNGLERRTKTYSEDNFEELQYFPNFYALLKSIDSEKEAKEKETLITIMKTLIDFVKMMVKYGTISPEEGVSYLENL 331
Cdd:pfam15467 238 TWDLPNGLERRNELSPEDGLQDLQYFPNFYRLLKSLNSEQDAKEKETLITIMKTLIDFVKMMVKYGTITPEEGVSYLENL 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19557645   332 DEMIALQTKNKLEKNATDNISKlfpAPSEKSHEETDSTKEEAAKMEKEYGSLKDSTKDDNSNPgGKTDEPkGKTEAYLEA 411
Cdd:pfam15467 318 DAMIALQTKNKLGKSLGTPDIK---APTGKNLEEDDNTKAEAAKMEKEYENLKDSTKEEQQNT-EETDQP-GKSETYLEA 392
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 19557645   412 IRKNIEWLKKHDKKGNKEDYDLSKMRDFINKQADAYVEKGILDKEEAEAIKRIYSSL 468
Cdd:pfam15467 393 IRKNIEWLKKHNKEGNKEDYDLSKLRDFMDQQVDSYIEKGILAKEEGDVIKRIYSSL 449
 
Name Accession Description Interval E-value
SGIII pfam15467
Secretogranin-3; Secretogranin_3 is a family of vertebrate proteins that is one of the granin ...
17-468 0e+00

Secretogranin-3; Secretogranin_3 is a family of vertebrate proteins that is one of the granin family. Granins are rich in acidic amino acids, exhibit aggregation at low pH, and possess a high capacity for calcium binding. Because granins are restricted in their localization to secretory granules of neuroendocrine cells, two interesting characteriztics of their sorting mechanisms have been observed. These are, first, that they aggregate on low pH/high calcium concentrations and second that two of them carry an N-terminal disulfide loop, mutations in which lead to mis-sorting. Thus, granins are thought to be essential for the sorting of secretory proteins at the trans-Golgi network. Chromogranin A (CgA) binds to SGIII in secretory granules of endocrine cells. SGIII directly binds to cholesterol components of the secretory granule membrane and targets CgA to secretory granules in pituitary and pancreatic endocrine cells. Mutations in the SGIII gene may influence the risk of obesity through possible regulation of hypothalamic neuropeptide secretion.


Pssm-ID: 464732  Cd Length: 449  Bit Score: 696.91  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19557645    17 IQAFPKPGGSQDKSLHNRELSAERPLNEQIAEAeeDKIKKTYPPENKPGQSNYSFVDNLNLLKAITEKEKiEKERQSIRS 96
Cdd:pfam15467   1 VSAFPTPGGSDDKAVYNRELSEERPLQEQIAEA--DSVKKSASKENPAASKNYSDADDLTLLKSLAEKQK-EKESASVRS 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19557645    97 SPLDNKLNVEDVDSTKNRKLIDDYDSTKSGLDHKFQDDPDGLHQLDGTPLTAEDIVHKIAARIYEENDRAVFDKIVSKLL 176
Cdd:pfam15467  78 KSGDDQYVPDDSDSTKNRRLADDYDSTKNGMDYKYQDDPDGLRQLDGTPLTAEDIVQKIATRIYEEDDRGVFDRIVSKLL 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19557645   177 NLGLITESQAHTLEDEVAEVLQKLISKEANNYE---EDPNKPTSWTE-NQAGKIPEKVTPMAAIQDGLAKGEN-DETVSN 251
Cdd:pfam15467 158 KLGLITESQADTLEYEVAEALQDLITKNAKNNEiedEDLDYPASRTEqDDAGKDEEKMEPPKPRQDEEDEEENeDDTVDN 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19557645   252 TLTLTNGLERRTKTYSEDNFEELQYFPNFYALLKSIDSEKEAKEKETLITIMKTLIDFVKMMVKYGTISPEEGVSYLENL 331
Cdd:pfam15467 238 TWDLPNGLERRNELSPEDGLQDLQYFPNFYRLLKSLNSEQDAKEKETLITIMKTLIDFVKMMVKYGTITPEEGVSYLENL 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19557645   332 DEMIALQTKNKLEKNATDNISKlfpAPSEKSHEETDSTKEEAAKMEKEYGSLKDSTKDDNSNPgGKTDEPkGKTEAYLEA 411
Cdd:pfam15467 318 DAMIALQTKNKLGKSLGTPDIK---APTGKNLEEDDNTKAEAAKMEKEYENLKDSTKEEQQNT-EETDQP-GKSETYLEA 392
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 19557645   412 IRKNIEWLKKHDKKGNKEDYDLSKMRDFINKQADAYVEKGILDKEEAEAIKRIYSSL 468
Cdd:pfam15467 393 IRKNIEWLKKHNKEGNKEDYDLSKLRDFMDQQVDSYIEKGILAKEEGDVIKRIYSSL 449
 
Name Accession Description Interval E-value
SGIII pfam15467
Secretogranin-3; Secretogranin_3 is a family of vertebrate proteins that is one of the granin ...
17-468 0e+00

Secretogranin-3; Secretogranin_3 is a family of vertebrate proteins that is one of the granin family. Granins are rich in acidic amino acids, exhibit aggregation at low pH, and possess a high capacity for calcium binding. Because granins are restricted in their localization to secretory granules of neuroendocrine cells, two interesting characteriztics of their sorting mechanisms have been observed. These are, first, that they aggregate on low pH/high calcium concentrations and second that two of them carry an N-terminal disulfide loop, mutations in which lead to mis-sorting. Thus, granins are thought to be essential for the sorting of secretory proteins at the trans-Golgi network. Chromogranin A (CgA) binds to SGIII in secretory granules of endocrine cells. SGIII directly binds to cholesterol components of the secretory granule membrane and targets CgA to secretory granules in pituitary and pancreatic endocrine cells. Mutations in the SGIII gene may influence the risk of obesity through possible regulation of hypothalamic neuropeptide secretion.


Pssm-ID: 464732  Cd Length: 449  Bit Score: 696.91  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19557645    17 IQAFPKPGGSQDKSLHNRELSAERPLNEQIAEAeeDKIKKTYPPENKPGQSNYSFVDNLNLLKAITEKEKiEKERQSIRS 96
Cdd:pfam15467   1 VSAFPTPGGSDDKAVYNRELSEERPLQEQIAEA--DSVKKSASKENPAASKNYSDADDLTLLKSLAEKQK-EKESASVRS 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19557645    97 SPLDNKLNVEDVDSTKNRKLIDDYDSTKSGLDHKFQDDPDGLHQLDGTPLTAEDIVHKIAARIYEENDRAVFDKIVSKLL 176
Cdd:pfam15467  78 KSGDDQYVPDDSDSTKNRRLADDYDSTKNGMDYKYQDDPDGLRQLDGTPLTAEDIVQKIATRIYEEDDRGVFDRIVSKLL 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19557645   177 NLGLITESQAHTLEDEVAEVLQKLISKEANNYE---EDPNKPTSWTE-NQAGKIPEKVTPMAAIQDGLAKGEN-DETVSN 251
Cdd:pfam15467 158 KLGLITESQADTLEYEVAEALQDLITKNAKNNEiedEDLDYPASRTEqDDAGKDEEKMEPPKPRQDEEDEEENeDDTVDN 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19557645   252 TLTLTNGLERRTKTYSEDNFEELQYFPNFYALLKSIDSEKEAKEKETLITIMKTLIDFVKMMVKYGTISPEEGVSYLENL 331
Cdd:pfam15467 238 TWDLPNGLERRNELSPEDGLQDLQYFPNFYRLLKSLNSEQDAKEKETLITIMKTLIDFVKMMVKYGTITPEEGVSYLENL 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19557645   332 DEMIALQTKNKLEKNATDNISKlfpAPSEKSHEETDSTKEEAAKMEKEYGSLKDSTKDDNSNPgGKTDEPkGKTEAYLEA 411
Cdd:pfam15467 318 DAMIALQTKNKLGKSLGTPDIK---APTGKNLEEDDNTKAEAAKMEKEYENLKDSTKEEQQNT-EETDQP-GKSETYLEA 392
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 19557645   412 IRKNIEWLKKHDKKGNKEDYDLSKMRDFINKQADAYVEKGILDKEEAEAIKRIYSSL 468
Cdd:pfam15467 393 IRKNIEWLKKHNKEGNKEDYDLSKLRDFMDQQVDSYIEKGILAKEEGDVIKRIYSSL 449
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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