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Conserved domains on  [gi|7019405|ref|NP_037452|]
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host cell factor 2 [Homo sapiens]

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 13286889)

fibronectin type III (FN3) domain-containing protein may be involved in specific interactions with other molecules through its FN3 domain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
14-332 4.85e-20

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 90.99  E-value: 4.85e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019405   14 SFTGPVPRARHGHRAVAIRELMIIFGGGNEG-IADELHVYNTATNQWflpaVRGDIPPGCAAHGFVC--DGTRILVFGGM 90
Cdd:COG3055   4 SSLPDLPTPRSEAAAALLDGKVYVAGGLSGGsASNSFEVYDPATNTW----SELAPLPGPPRHHAAAvaQDGKLYVFGGF 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019405   91 VEYGRYSN-----ELYELQASRWlwkkvkphpPPSGLPPCPRLGHSFSLYGNKCYLFGGlanesedsnNNVPRYLNDFYE 165
Cdd:COG3055  80 TGANPSSTplndvYVYDPATNTW---------TKLAPMPTPRGGATALLLDGKIYVVGG---------WDDGGNVAWVEV 141

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019405  166 LELQHGSgvvgWSipvTKGVVPSPRESHTAVIyckkdSGSPKMYVFGGMCGARLDDLWqldletmswskpETKGTVPLPR 245
Cdd:COG3055 142 YDPATGT----WT---QLAPLPTPRDHLAAAV-----LPDGKILVIGGRNGSGFSNTW------------TTLAPLPTAR 197

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019405  246 SLHTASVIGNKMYIFGGwvphkgentETSPHDCEWRctssfsyLNLDTTEWTTLvsdsqedkkNSRPRPRAGHCAVAIGT 325
Cdd:COG3055 198 AGHAAAVLGGKILVFGG---------ESGFSDEVEA-------YDPATNTWTAL---------GELPTPRHGHAAVLTDG 252


                ....*..
gi 7019405  326 RLYFWSG 332
Cdd:COG3055 253 KVYVIGG 259
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 618-672 3.25e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 43.25  E-value: 3.25e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 7019405  618 PKGKQSISKVGNADVPDYSLlKKQDLVPGTGYRFRVAAINGCGIGPFSKISEFKT 672
Cdd:cd00063  40 EKGSGDWKEVEVTPGSETSY-TLTGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 678-778 6.32e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 39.40  E-value: 6.32e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019405  678 PGAPSAVRISKNVEG-IHLSWEPPTSPSGNILEYSaylaIRTAQIQDNPSQLVfmRIYCGLKTSCIVTagQLaNAHIDYT 756
Cdd:cd00063   1 PSPPTNLRVTDVTSTsVTLSWTPPEDDGGPITGYV----VEYREKGSGDWKEV--EVTPGSETSYTLT--GL-KPGTEYE 71

                        90       100
                ....*....|....*....|..
gi 7019405  757 srpaivFRISAKNEKGYGPATQ 778
Cdd:cd00063  72 ------FRVRAVNGGGESPPSE 87
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 312-355 1.35e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


:

Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 37.16  E-value: 1.35e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 7019405    312 PRPRAGHCAVAIGTRLYFWSGRDGYkkalNSQVcCKDLWYLDTE 355
Cdd:pfam13854   1 PVPRYGHCAVTVGDYIYLYGGYTGG----EGQP-SDDVYVLSLP 39
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
535-704 6.92e-03

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 39.99  E-value: 6.92e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019405  535 STNGAVVKDETSLTTFSTKSEVDETY--ALPATKISRVETHATATPFSKETPSNPVATVKAGERQWCDVGIFKNNTALVS 612
Cdd:COG3401  82 VAVAAAPPTATGLTTLTGSGSVGGATntGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTAS 161

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019405  613 Q-------FYLLPKGKQSISKVGNADVPDYSLLKKQDLVPGTGYRFRVAAINGCGIGPFSKISEFKTcIPGFPGAPSAVR 685
Cdd:COG3401 162 SvagagvvVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTT-PTTPPSAPTGLT 240

                       170       180
                ....*....|....*....|
gi 7019405  686 ISKNVEG-IHLSWEPPTSPS 704
Cdd:COG3401 241 ATADTPGsVTLSWDPVTESD 260
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
14-332 4.85e-20

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 90.99  E-value: 4.85e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019405   14 SFTGPVPRARHGHRAVAIRELMIIFGGGNEG-IADELHVYNTATNQWflpaVRGDIPPGCAAHGFVC--DGTRILVFGGM 90
Cdd:COG3055   4 SSLPDLPTPRSEAAAALLDGKVYVAGGLSGGsASNSFEVYDPATNTW----SELAPLPGPPRHHAAAvaQDGKLYVFGGF 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019405   91 VEYGRYSN-----ELYELQASRWlwkkvkphpPPSGLPPCPRLGHSFSLYGNKCYLFGGlanesedsnNNVPRYLNDFYE 165
Cdd:COG3055  80 TGANPSSTplndvYVYDPATNTW---------TKLAPMPTPRGGATALLLDGKIYVVGG---------WDDGGNVAWVEV 141

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019405  166 LELQHGSgvvgWSipvTKGVVPSPRESHTAVIyckkdSGSPKMYVFGGMCGARLDDLWqldletmswskpETKGTVPLPR 245
Cdd:COG3055 142 YDPATGT----WT---QLAPLPTPRDHLAAAV-----LPDGKILVIGGRNGSGFSNTW------------TTLAPLPTAR 197

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019405  246 SLHTASVIGNKMYIFGGwvphkgentETSPHDCEWRctssfsyLNLDTTEWTTLvsdsqedkkNSRPRPRAGHCAVAIGT 325
Cdd:COG3055 198 AGHAAAVLGGKILVFGG---------ESGFSDEVEA-------YDPATNTWTAL---------GELPTPRHGHAAVLTDG 252


                ....*..
gi 7019405  326 RLYFWSG 332
Cdd:COG3055 253 KVYVIGG 259
PLN02193 PLN02193
nitrile-specifier protein
 2-262 5.94e-12

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 68.83  E-value: 5.94e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019405     2 AAPSLL-NWRRV-SSFTGPVPRARHGHRAVAIRelMIIFGGG---NEGIADELHVYNTATNQWFLPAVRGDIPP-GCAAH 75
Cdd:PLN02193 145 STPKLLgKWIKVeQKGEGPGLRCSHGIAQVGNK--IYSFGGEftpNQPIDKHLYVFDLETRTWSISPATGDVPHlSCLGV 222

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019405    76 GFVCDGTRILVFGGMvEYGRYSNELYELQASRWLWKKVkphpPPSGLPPCPRLGHSFSLYGNKCYLFGGLANESE----D 151
Cdd:PLN02193 223 RMVSIGSTLYVFGGR-DASRQYNGFYSFDTTTNEWKLL----TPVEEGPTPRSFHSMAADEENVYVFGGVSATARlktlD 297

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019405   152 SNNNVPRylndfyelELQHGSgvvgwsipvtkgvvpSPRESHTAVIYCKKDSGSPKMYVFGGMCGARLDDLWQLDLETMS 231
Cdd:PLN02193 298 SYNIVDK--------KWFHCS---------------TPGDSFSIRGGAGLEVVQGKVWVVYGFNGCEVDDVHYYDPVQDK 354

                        250       260       270
                 ....*....|....*....|....*....|.
gi 7019405   232 WSKPETKGTVPLPRSLHTASVIGNKMYIFGG 262
Cdd:PLN02193 355 WTQVETFGVRPSERSVFASAAVGKHIVIFGG 385
Kelch_3 pfam13415
Galactose oxidase, central domain;
207-253 1.85e-06

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 45.36  E-value: 1.85e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 7019405    207 KMYVFGGMC---GARLDDLWQLDLETMSWSKPetkGTVPLPRSLHTASVI 253
Cdd:pfam13415   3 KLYIFGGLGfdgQTRLNDLYVYDLDTNTWTQI---GDLPPPRSGHSATYI 49
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 618-672 3.25e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 43.25  E-value: 3.25e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 7019405  618 PKGKQSISKVGNADVPDYSLlKKQDLVPGTGYRFRVAAINGCGIGPFSKISEFKT 672
Cdd:cd00063  40 EKGSGDWKEVEVTPGSETSY-TLTGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
641-665 2.76e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 40.48  E-value: 2.76e-04
                          10        20
                  ....*....|....*....|....*
gi 7019405    641 QDLVPGTGYRFRVAAINGCGIGPFS 665
Cdd:pfam00041  61 TGLKPGTEYEVRVQAVNGGGEGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 678-778 6.32e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 39.40  E-value: 6.32e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019405  678 PGAPSAVRISKNVEG-IHLSWEPPTSPSGNILEYSaylaIRTAQIQDNPSQLVfmRIYCGLKTSCIVTagQLaNAHIDYT 756
Cdd:cd00063   1 PSPPTNLRVTDVTSTsVTLSWTPPEDDGGPITGYV----VEYREKGSGDWKEV--EVTPGSETSYTLT--GL-KPGTEYE 71

                        90       100
                ....*....|....*....|..
gi 7019405  757 srpaivFRISAKNEKGYGPATQ 778
Cdd:cd00063  72 ------FRVRAVNGGGESPPSE 87
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 312-355 1.35e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 37.16  E-value: 1.35e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 7019405    312 PRPRAGHCAVAIGTRLYFWSGRDGYkkalNSQVcCKDLWYLDTE 355
Cdd:pfam13854   1 PVPRYGHCAVTVGDYIYLYGGYTGG----EGQP-SDDVYVLSLP 39
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
535-704 6.92e-03

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 39.99  E-value: 6.92e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019405  535 STNGAVVKDETSLTTFSTKSEVDETY--ALPATKISRVETHATATPFSKETPSNPVATVKAGERQWCDVGIFKNNTALVS 612
Cdd:COG3401  82 VAVAAAPPTATGLTTLTGSGSVGGATntGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTAS 161

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019405  613 Q-------FYLLPKGKQSISKVGNADVPDYSLLKKQDLVPGTGYRFRVAAINGCGIGPFSKISEFKTcIPGFPGAPSAVR 685
Cdd:COG3401 162 SvagagvvVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTT-PTTPPSAPTGLT 240

                       170       180
                ....*....|....*....|
gi 7019405  686 ISKNVEG-IHLSWEPPTSPS 704
Cdd:COG3401 241 ATADTPGsVTLSWDPVTESD 260
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
14-332 4.85e-20

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 90.99  E-value: 4.85e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019405   14 SFTGPVPRARHGHRAVAIRELMIIFGGGNEG-IADELHVYNTATNQWflpaVRGDIPPGCAAHGFVC--DGTRILVFGGM 90
Cdd:COG3055   4 SSLPDLPTPRSEAAAALLDGKVYVAGGLSGGsASNSFEVYDPATNTW----SELAPLPGPPRHHAAAvaQDGKLYVFGGF 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019405   91 VEYGRYSN-----ELYELQASRWlwkkvkphpPPSGLPPCPRLGHSFSLYGNKCYLFGGlanesedsnNNVPRYLNDFYE 165
Cdd:COG3055  80 TGANPSSTplndvYVYDPATNTW---------TKLAPMPTPRGGATALLLDGKIYVVGG---------WDDGGNVAWVEV 141

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019405  166 LELQHGSgvvgWSipvTKGVVPSPRESHTAVIyckkdSGSPKMYVFGGMCGARLDDLWqldletmswskpETKGTVPLPR 245
Cdd:COG3055 142 YDPATGT----WT---QLAPLPTPRDHLAAAV-----LPDGKILVIGGRNGSGFSNTW------------TTLAPLPTAR 197

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019405  246 SLHTASVIGNKMYIFGGwvphkgentETSPHDCEWRctssfsyLNLDTTEWTTLvsdsqedkkNSRPRPRAGHCAVAIGT 325
Cdd:COG3055 198 AGHAAAVLGGKILVFGG---------ESGFSDEVEA-------YDPATNTWTAL---------GELPTPRHGHAAVLTDG 252


                ....*..
gi 7019405  326 RLYFWSG 332
Cdd:COG3055 253 KVYVIGG 259
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
9-264 2.02e-18

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 86.36  E-value: 2.02e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019405    9 WRRVSSFTGPvprARHGHRAVAIRELMIIFGG-----GNEGIADELHVYNTATNQWFlpaVRGDIPPGCAAHGFVCDGTR 83
Cdd:COG3055  50 WSELAPLPGP---PRHHAAAVAQDGKLYVFGGftganPSSTPLNDVYVYDPATNTWT---KLAPMPTPRGGATALLLDGK 123

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019405   84 ILVFGGMVEYGRYSN-ELYELQASRWlwkkvkphpPPSGLPPCPRLGHS-FSLYGNKCYLFGGlANESEDSNNnvpryln 161
Cdd:COG3055 124 IYVVGGWDDGGNVAWvEVYDPATGTW---------TQLAPLPTPRDHLAaAVLPDGKILVIGG-RNGSGFSNT------- 186

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019405  162 dfyelelqhgsgvvgWSipvTKGVVPSPRESHTAVIYckkdsgSPKMYVFGGMCGArLDDLWQLDLETMSWSkpeTKGTV 241
Cdd:COG3055 187 ---------------WT---TLAPLPTARAGHAAAVL------GGKILVFGGESGF-SDEVEAYDPATNTWT---ALGEL 238

                       250       260
                ....*....|....*....|...
gi 7019405  242 PLPRSLHTASVIGNKMYIFGGWV 264
Cdd:COG3055 239 PTPRHGHAAVLTDGKVYVIGGET 261
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
134-335 7.27e-17

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 81.74  E-value: 7.27e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019405  134 LYGNKCYLFGGLANESedsnnnvprYLNDFYELELQHGSgvvgWSipvTKGVVPSPRESHTAVIYCKKdsgspKMYVFGG 213
Cdd:COG3055  20 LLDGKVYVAGGLSGGS---------ASNSFEVYDPATNT----WS---ELAPLPGPPRHHAAAVAQDG-----KLYVFGG 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019405  214 MCGAR-----LDDLWQLDLETMSWSKpetKGTVPLPRSLHTASVIGNKMYIFGGWVPHKGentetsphdcewrcTSSFSY 288
Cdd:COG3055  79 FTGANpsstpLNDVYVYDPATNTWTK---LAPMPTPRGGATALLLDGKIYVVGGWDDGGN--------------VAWVEV 141

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 7019405  289 LNLDTTEWTTLVSDsqedkknsrPRPRAGHCA-VAIGTRLYFWSGRDG 335
Cdd:COG3055 142 YDPATGTWTQLAPL---------PTPRDHLAAaVLPDGKILVIGGRNG 180
PLN02193 PLN02193
nitrile-specifier protein
 2-262 5.94e-12

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 68.83  E-value: 5.94e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019405     2 AAPSLL-NWRRV-SSFTGPVPRARHGHRAVAIRelMIIFGGG---NEGIADELHVYNTATNQWFLPAVRGDIPP-GCAAH 75
Cdd:PLN02193 145 STPKLLgKWIKVeQKGEGPGLRCSHGIAQVGNK--IYSFGGEftpNQPIDKHLYVFDLETRTWSISPATGDVPHlSCLGV 222

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019405    76 GFVCDGTRILVFGGMvEYGRYSNELYELQASRWLWKKVkphpPPSGLPPCPRLGHSFSLYGNKCYLFGGLANESE----D 151
Cdd:PLN02193 223 RMVSIGSTLYVFGGR-DASRQYNGFYSFDTTTNEWKLL----TPVEEGPTPRSFHSMAADEENVYVFGGVSATARlktlD 297

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019405   152 SNNNVPRylndfyelELQHGSgvvgwsipvtkgvvpSPRESHTAVIYCKKDSGSPKMYVFGGMCGARLDDLWQLDLETMS 231
Cdd:PLN02193 298 SYNIVDK--------KWFHCS---------------TPGDSFSIRGGAGLEVVQGKVWVVYGFNGCEVDDVHYYDPVQDK 354

                        250       260       270
                 ....*....|....*....|....*....|.
gi 7019405   232 WSKPETKGTVPLPRSLHTASVIGNKMYIFGG 262
Cdd:PLN02193 355 WTQVETFGVRPSERSVFASAAVGKHIVIFGG 385
PLN02153 PLN02153
epithiospecifier protein
 16-264 3.25e-10

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 62.31  E-value: 3.25e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019405    16 TGPVPRARHGHRAVAirELMIIFGGG---NEGIADELHVYNTATNQWFLPAVRGDIPP-GCAAHGFVCDGTRILVFGGMV 91
Cdd:PLN02153  18 KGPGPRCSHGIAVVG--DKLYSFGGElkpNEHIDKDLYVFDFNTHTWSIAPANGDVPRiSCLGVRMVAVGTKLYIFGGRD 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019405    92 EYGRYSN-ELYELQASRWLWkkvkPHPPPSGLPPCPRLGHSFSLYGNKCYLFGGLaneSEDSNNNVPRYLNDFYELELQH 170
Cdd:PLN02153  96 EKREFSDfYSYDTVKNEWTF----LTKLDEEGGPEARTFHSMASDENHVYVFGGV---SKGGLMKTPERFRTIEAYNIAD 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019405   171 GsgvvGWSipvtkgVVPSPRESHTA--------------VIYCKKDSGSPkmyvfGGMCGARLDDLWQLDLETMSWSKPE 236
Cdd:PLN02153 169 G----KWV------QLPDPGENFEKrggagfavvqgkiwVVYGFATSILP-----GGKSDYESNAVQFFDPASGKWTEVE 233

                        250       260
                 ....*....|....*....|....*...
gi 7019405   237 TKGTVPLPRSLHTASVIGNKMYIFGGWV 264
Cdd:PLN02153 234 TTGAKPSARSVFAHAVVGKYIIIFGGEV 261
PLN02193 PLN02193
nitrile-specifier protein
 77-262 5.67e-07

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 53.04  E-value: 5.67e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019405    77 FVCDGTRILVFggmveYGRYSNELYELQASRWL---------WKKVKPHPPPSGLppcpRLGHSFSLYGNKCYLFGGlan 147
Cdd:PLN02193 116 FVLQGGKIVGF-----HGRSTDVLHSLGAYISLpstpkllgkWIKVEQKGEGPGL----RCSHGIAQVGNKIYSFGG--- 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019405   148 eSEDSNNNVPRYLNDFyELELQhgsgvvGWSIPVTKGVVPspresHTAVIYCKKDSGSPKMYVFGGMCGAR-LDDLWQLD 226
Cdd:PLN02193 184 -EFTPNQPIDKHLYVF-DLETR------TWSISPATGDVP-----HLSCLGVRMVSIGSTLYVFGGRDASRqYNGFYSFD 250

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 7019405   227 LETMSWS--KPETKGtvPLPRSLHTASVIGNKMYIFGG 262
Cdd:PLN02193 251 TTTNEWKllTPVEEG--PTPRSFHSMAADEENVYVFGG 286
Kelch_3 pfam13415
Galactose oxidase, central domain;
207-253 1.85e-06

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 45.36  E-value: 1.85e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 7019405    207 KMYVFGGMC---GARLDDLWQLDLETMSWSKPetkGTVPLPRSLHTASVI 253
Cdd:pfam13415   3 KLYIFGGLGfdgQTRLNDLYVYDLDTNTWTQI---GDLPPPRSGHSATYI 49
PLN02193 PLN02193
nitrile-specifier protein
 232-375 4.45e-06

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 49.95  E-value: 4.45e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019405   232 WSKPETKGTVPLPRSLHTASVIGNKMYIFGgwvphkGENTETSPHDcewrctSSFSYLNLDTTEWTtlVSDSQEDKKNSR 311
Cdd:PLN02193 153 WIKVEQKGEGPGLRCSHGIAQVGNKIYSFG------GEFTPNQPID------KHLYVFDLETRTWS--ISPATGDVPHLS 218

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 7019405   312 PrprAGHCAVAIGTRLYFWSGRDGYKK--ALNSQVCCKDLWYLDT--EKPPAPSQVQLIKATTNSFHV 375
Cdd:PLN02193 219 C---LGVRMVSIGSTLYVFGGRDASRQynGFYSFDTTTNEWKLLTpvEEGPTPRSFHSMAADEENVYV 283
PRK14131 PRK14131
N-acetylneuraminate epimerase;
9-89 6.60e-06

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 49.24  E-value: 6.60e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019405     9 WRRVSSFTGPvprARHGHRAVAIRELMIIFGG----GNEG---IADELHVYNTATNQWFLPAVRGdiPPGCAAH-GFVCD 80
Cdd:PRK14131  64 WTKIAAFPGG---PREQAVAAFIDGKLYVFGGigktNSEGspqVFDDVYKYDPKTNSWQKLDTRS--PVGLAGHvAVSLH 138


                 ....*....
gi 7019405    81 GTRILVFGG 89
Cdd:PRK14131 139 NGKAYITGG 147
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
8-104 7.08e-06

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 48.61  E-value: 7.08e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019405    8 NWRRVSSFtgPVPRARHGHRAVAIRelmIIFGGGNEGIADELHVYNTATNQWFlpaVRGDIPPGCAAHGFVCDGTRILVF 87
Cdd:COG3055 186 TWTTLAPL--PTARAGHAAAVLGGK---ILVFGGESGFSDEVEAYDPATNTWT---ALGELPTPRHGHAAVLTDGKVYVI 257

                        90
                ....*....|....*..
gi 7019405   88 GGMVEYGRYSNELYELQ 104
Cdd:COG3055 258 GGETKPGVRTPLVTSAE 274
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 618-672 3.25e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 43.25  E-value: 3.25e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 7019405  618 PKGKQSISKVGNADVPDYSLlKKQDLVPGTGYRFRVAAINGCGIGPFSKISEFKT 672
Cdd:cd00063  40 EKGSGDWKEVEVTPGSETSY-TLTGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
641-665 2.76e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 40.48  E-value: 2.76e-04
                          10        20
                  ....*....|....*....|....*
gi 7019405    641 QDLVPGTGYRFRVAAINGCGIGPFS 665
Cdd:pfam00041  61 TGLKPGTEYEVRVQAVNGGGEGPPS 85
Kelch_3 pfam13415
Galactose oxidase, central domain;
254-323 3.03e-04

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 39.20  E-value: 3.03e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019405    254 GNKMYIFGGWVPHKGEntetsphdcewrCTSSFSYLNLDTTEWTTLvsdsqedkkNSRPRPRAGHCAVAI 323
Cdd:pfam13415   1 GDKLYIFGGLGFDGQT------------RLNDLYVYDLDTNTWTQI---------GDLPPPRSGHSATYI 49
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 678-778 6.32e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 39.40  E-value: 6.32e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019405  678 PGAPSAVRISKNVEG-IHLSWEPPTSPSGNILEYSaylaIRTAQIQDNPSQLVfmRIYCGLKTSCIVTagQLaNAHIDYT 756
Cdd:cd00063   1 PSPPTNLRVTDVTSTsVTLSWTPPEDDGGPITGYV----VEYREKGSGDWKEV--EVTPGSETSYTLT--GL-KPGTEYE 71

                        90       100
                ....*....|....*....|..
gi 7019405  757 srpaivFRISAKNEKGYGPATQ 778
Cdd:cd00063  72 ------FRVRAVNGGGESPPSE 87
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
642-703 6.46e-04

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 43.07  E-value: 6.46e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 7019405  642 DLVPGTGYRFRVAAINGCGI-GPFSKISEFKTCIPGfPGAPSAVRISKNVE-GIHLSWEPPTSP 703
Cdd:COG3401 291 GLTNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDLTP-PAAPSGLTATAVGSsSITLSWTASSDA 353
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 244-301 9.68e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 37.59  E-value: 9.68e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 7019405    244 PRSLHTASVIGNKMYIFGGWvphkgentetsphdCEWRCTSSFSYLNLDTTEWTTLVS 301
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGF--------------DGNQSLNSVEVYDPETNTWSKLPS 44
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
231-337 9.92e-04

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 41.68  E-value: 9.92e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019405  231 SWSkpeTKGTVPLPRSLHTASVIGNKMYIFGGWvphkGENTETSPHDCewrctssfsyLNLDTTEWTTLVSDSQEdkkns 310
Cdd:COG3055   2 TWS---SLPDLPTPRSEAAAALLDGKVYVAGGL----SGGSASNSFEV----------YDPATNTWSELAPLPGP----- 59

                        90       100
                ....*....|....*....|....*..
gi 7019405  311 rprPRAGHCAVAIGTRLYFWSGRDGYK 337
Cdd:COG3055  60 ---PRHHAAAVAQDGKLYVFGGFTGAN 83
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 312-355 1.35e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 37.16  E-value: 1.35e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 7019405    312 PRPRAGHCAVAIGTRLYFWSGRDGYkkalNSQVcCKDLWYLDTE 355
Cdd:pfam13854   1 PVPRYGHCAVTVGDYIYLYGGYTGG----EGQP-SDDVYVLSLP 39
Kelch_4 pfam13418
Galactose oxidase, central domain;
189-234 1.50e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 37.21  E-value: 1.50e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 7019405    189 PRESHTAViYCKKDSGspkmYVFGGMC--GARLDDLWQLDLETMSWSK 234
Cdd:pfam13418   1 PRAYHTST-SIPDDTI----YLFGGEGedGTLLSDLWVFDLSTNEWTR 43
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 187-229 1.86e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 36.77  E-value: 1.86e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 7019405    187 PSPRESHTAVIYckkdsgSPKMYVFGGMCGAR---LDDLWQLDLET 229
Cdd:pfam13854   1 PVPRYGHCAVTV------GDYIYLYGGYTGGEgqpSDDVYVLSLPT 40
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
535-704 6.92e-03

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 39.99  E-value: 6.92e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019405  535 STNGAVVKDETSLTTFSTKSEVDETY--ALPATKISRVETHATATPFSKETPSNPVATVKAGERQWCDVGIFKNNTALVS 612
Cdd:COG3401  82 VAVAAAPPTATGLTTLTGSGSVGGATntGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTAS 161

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019405  613 Q-------FYLLPKGKQSISKVGNADVPDYSLLKKQDLVPGTGYRFRVAAINGCGIGPFSKISEFKTcIPGFPGAPSAVR 685
Cdd:COG3401 162 SvagagvvVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTT-PTTPPSAPTGLT 240

                       170       180
                ....*....|....*....|
gi 7019405  686 ISKNVEG-IHLSWEPPTSPS 704
Cdd:COG3401 241 ATADTPGsVTLSWDPVTESD 260
Kelch_3 pfam13415
Galactose oxidase, central domain;
136-198 9.16e-03

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 34.96  E-value: 9.16e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 7019405    136 GNKCYLFGGLANESEDsnnnvprYLNDFYELELQHGSgvvgWsipVTKGVVPSPRESHTAVIY 198
Cdd:pfam13415   1 GDKLYIFGGLGFDGQT-------RLNDLYVYDLDTNT----W---TQIGDLPPPRSGHSATYI 49
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 22-59 9.72e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 34.90  E-value: 9.72e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 7019405     22 ARHGHRAVAIRELMIIFGGGNEGIA-DELHVYNTATNQW 59
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSlNSVEVYDPETNTW 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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