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Conserved domains on  [gi|7661728|ref|NP_054736|]
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ragulator complex protein LAMTOR2 isoform 1 [Homo sapiens]

Protein Classification

roadblock/LC7 domain-containing protein( domain architecture ID 10505491)

roadblock/LC7 domain-containing protein similar to Homo sapiens dynein light chain roadblock-type 1 and 2, and ragulator complex protein LAMTOR2

CATH:  3.30.450.30
PubMed:  10402468|11084347

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Robl_LC7 pfam03259
Roadblock/LC7 domain; This family includes proteins that are about 100 amino acids long and ...
 5-95 3.41e-17

Roadblock/LC7 domain; This family includes proteins that are about 100 amino acids long and have been shown to be related. Members of this family of proteins are associated with both flagellar outer arm dynein and Drosophila and rat brain cytoplasmic dynein. It is proposed that roadblock/LC7 family members may modulate specific dynein functions. This family also includes Golgi-associated MP1 adapter protein and MglB from Myxococcus xanthus, a protein involved in gliding motility. However the family also includes members from non-motile bacteria such as Streptomyces coelicolor, suggesting that the protein may play a structural or regulatory role.


:

Pssm-ID: 397386  Cd Length: 91  Bit Score: 70.73  E-value: 3.41e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661728      5 KALTQVLSQANTGGVQSTLLLNNEGSLLAYSGYGDTDARVTAAIASNIWAAYDRNGNQaFNEDNLKFILMDCMEGRVAIT 84
Cdd:pfam03259   1 LDEELLDLLQRVPGVRGALVVSKDGLVIASSTLDNDDADHLAALASGLLSAAKGAARD-LGSGELRQLLIEGKKGELYLT 79

                          90
                  ....*....|..
gi 7661728     85 RVAN-LLLCMYA 95
Cdd:pfam03259  80 PAGEgALLVVLA 91
 
Name Accession Description Interval E-value
Robl_LC7 pfam03259
Roadblock/LC7 domain; This family includes proteins that are about 100 amino acids long and ...
 5-95 3.41e-17

Roadblock/LC7 domain; This family includes proteins that are about 100 amino acids long and have been shown to be related. Members of this family of proteins are associated with both flagellar outer arm dynein and Drosophila and rat brain cytoplasmic dynein. It is proposed that roadblock/LC7 family members may modulate specific dynein functions. This family also includes Golgi-associated MP1 adapter protein and MglB from Myxococcus xanthus, a protein involved in gliding motility. However the family also includes members from non-motile bacteria such as Streptomyces coelicolor, suggesting that the protein may play a structural or regulatory role.


Pssm-ID: 397386  Cd Length: 91  Bit Score: 70.73  E-value: 3.41e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661728      5 KALTQVLSQANTGGVQSTLLLNNEGSLLAYSGYGDTDARVTAAIASNIWAAYDRNGNQaFNEDNLKFILMDCMEGRVAIT 84
Cdd:pfam03259   1 LDEELLDLLQRVPGVRGALVVSKDGLVIASSTLDNDDADHLAALASGLLSAAKGAARD-LGSGELRQLLIEGKKGELYLT 79

                          90
                  ....*....|..
gi 7661728     85 RVAN-LLLCMYA 95
Cdd:pfam03259  80 PAGEgALLVVLA 91
Robl_LC7 smart00960
Roadblock/LC7 domain; This family includes proteins that are about 100 amino acids long and ...
 13-93 8.58e-14

Roadblock/LC7 domain; This family includes proteins that are about 100 amino acids long and have been shown to be related. Members of this family of proteins are associated with both flagellar outer arm dynein and Drosophila and rat brain cytoplasmic dynein. It is proposed that roadblock/LC7 family members may modulate specific dynein functions. This family also includes Golgi-associated MP1 adapter protein and MglB from Myxococcus xanthus, a protein involved in gliding motility. However the family also includes members from non-motile bacteria such as Streptomyces coelicolor, suggesting that the protein may play a structural or regulatory role.


Pssm-ID: 214939  Cd Length: 88  Bit Score: 61.82  E-value: 8.58e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661728      13 QANTGGVQSTLLLNNEGSLLAYSGYGDTDARVTAAIASNIWAAYDRNGnQAFNEDNLKFILMDCMEGRVAITRVANLLLC 92
Cdd:smart00960   8 LARVPGVRGALVVSRDGLLLASSGLSDDDAERLAALAAGLLSLAERAA-RELGEGELRQLRIEGEKGEVLITPAGDALLA 86


                   .
gi 7661728      93 M 93
Cdd:smart00960  87 V 87
COG2018 COG2018
Predicted regulator of Ras-like GTPase activity, Roadblock/LC7/MglB family [Signal ...
 3-120 2.24e-03

Predicted regulator of Ras-like GTPase activity, Roadblock/LC7/MglB family [Signal transduction mechanisms];


Pssm-ID: 441621  Cd Length: 123  Bit Score: 35.21  E-value: 2.24e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661728    3 RPKALTQVLSQ--ANTGGVQSTLLLNNEGSLLA-YSGYGDTDARVTAAIASNIWAAYDRNGnQAFNEDNLKFILMDCMEG 79
Cdd:COG2018   2 QAEKLDWLLDDlvERVPGVRGAVLVSADGLLIAsSLGLDDDDAERLAAMAAGLLSLARRAA-RELGAGEVEQVVVEGERG 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 7661728   80 RVAITRV-ANLLLCMYAKETVGFGMLKAKAQALVQYLEEPLT 120
Cdd:COG2018  81 YLLVTAAgDGAVLAVLADPDADLGLVRYEMRRLAERLGELLT 122
 
Name Accession Description Interval E-value
Robl_LC7 pfam03259
Roadblock/LC7 domain; This family includes proteins that are about 100 amino acids long and ...
 5-95 3.41e-17

Roadblock/LC7 domain; This family includes proteins that are about 100 amino acids long and have been shown to be related. Members of this family of proteins are associated with both flagellar outer arm dynein and Drosophila and rat brain cytoplasmic dynein. It is proposed that roadblock/LC7 family members may modulate specific dynein functions. This family also includes Golgi-associated MP1 adapter protein and MglB from Myxococcus xanthus, a protein involved in gliding motility. However the family also includes members from non-motile bacteria such as Streptomyces coelicolor, suggesting that the protein may play a structural or regulatory role.


Pssm-ID: 397386  Cd Length: 91  Bit Score: 70.73  E-value: 3.41e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661728      5 KALTQVLSQANTGGVQSTLLLNNEGSLLAYSGYGDTDARVTAAIASNIWAAYDRNGNQaFNEDNLKFILMDCMEGRVAIT 84
Cdd:pfam03259   1 LDEELLDLLQRVPGVRGALVVSKDGLVIASSTLDNDDADHLAALASGLLSAAKGAARD-LGSGELRQLLIEGKKGELYLT 79

                          90
                  ....*....|..
gi 7661728     85 RVAN-LLLCMYA 95
Cdd:pfam03259  80 PAGEgALLVVLA 91
Robl_LC7 smart00960
Roadblock/LC7 domain; This family includes proteins that are about 100 amino acids long and ...
 13-93 8.58e-14

Roadblock/LC7 domain; This family includes proteins that are about 100 amino acids long and have been shown to be related. Members of this family of proteins are associated with both flagellar outer arm dynein and Drosophila and rat brain cytoplasmic dynein. It is proposed that roadblock/LC7 family members may modulate specific dynein functions. This family also includes Golgi-associated MP1 adapter protein and MglB from Myxococcus xanthus, a protein involved in gliding motility. However the family also includes members from non-motile bacteria such as Streptomyces coelicolor, suggesting that the protein may play a structural or regulatory role.


Pssm-ID: 214939  Cd Length: 88  Bit Score: 61.82  E-value: 8.58e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661728      13 QANTGGVQSTLLLNNEGSLLAYSGYGDTDARVTAAIASNIWAAYDRNGnQAFNEDNLKFILMDCMEGRVAITRVANLLLC 92
Cdd:smart00960   8 LARVPGVRGALVVSRDGLLLASSGLSDDDAERLAALAAGLLSLAERAA-RELGEGELRQLRIEGEKGEVLITPAGDALLA 86


                   .
gi 7661728      93 M 93
Cdd:smart00960  87 V 87
COG2018 COG2018
Predicted regulator of Ras-like GTPase activity, Roadblock/LC7/MglB family [Signal ...
 3-120 2.24e-03

Predicted regulator of Ras-like GTPase activity, Roadblock/LC7/MglB family [Signal transduction mechanisms];


Pssm-ID: 441621  Cd Length: 123  Bit Score: 35.21  E-value: 2.24e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661728    3 RPKALTQVLSQ--ANTGGVQSTLLLNNEGSLLA-YSGYGDTDARVTAAIASNIWAAYDRNGnQAFNEDNLKFILMDCMEG 79
Cdd:COG2018   2 QAEKLDWLLDDlvERVPGVRGAVLVSADGLLIAsSLGLDDDDAERLAAMAAGLLSLARRAA-RELGAGEVEQVVVEGERG 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 7661728   80 RVAITRV-ANLLLCMYAKETVGFGMLKAKAQALVQYLEEPLT 120
Cdd:COG2018  81 YLLVTAAgDGAVLAVLADPDADLGLVRYEMRRLAERLGELLT 122
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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