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Conserved domains on  [gi|46094072|ref|NP_054825|]
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zinc finger protein 770 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 13826075)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
42-66 9.71e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 9.71e-04
                          10        20
                  ....*....|....*....|....*
gi 46094072    42 LARHYLIHTGQKPFECDVCHKTFRQ 66
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
640-664 5.52e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.52e-03
                          10        20
                  ....*....|....*....|....*
gi 46094072   640 LERHYLIHAGQKPFECSVCGKTFRQ 664
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 super family cl34881
FOG: Zn-finger [General function prediction only];
185-530 7.18e-03

FOG: Zn-finger [General function prediction only];


The actual alignment was detected with superfamily member COG5048:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.29  E-value: 7.18e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46094072 185 QRPFKCVLCTKSFRQSTHLKIHQLTHSEERPFQCCFCQKGFKIQSKLLKHKQIHTRNKAFRALLLKKRRTESRPLPNKLN 264
Cdd:COG5048  31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSL 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46094072 265 ANQGGFENGEIGES------EENNPLDVHSIYIVPFQCPKCEKCFESEQILNEHSCFAARSGKIPSRFKRSYNYK-TIVK 337
Cdd:COG5048 111 SSSSSNSNDNNLLSshslppSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSlLISS 190

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46094072 338 KILAKLKRARSKKLDNFQSEKKVFKkSFLRNCDLISGEQSSEQTQRtfvgslgKHGTYKTIGNRKKKTLTLPFSWQNMGk 417
Cdd:COG5048 191 NVSTSIPSSSENSPLSSSYSIPSSS-SDQNLENSSSSLPLTTNSQL-------SPKSLLSQSPSSLSSSDSSSSASESP- 261

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46094072 418 nlkgilttENILSIDNSVNKKDLSICGSSGEEFFNNCEVLQCGFSVPRENIRTRHK-------------ICPCDKCEKVF 484
Cdd:COG5048 262 --------RSSLPTASSQSSSPNESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLrsvnhsgeslkpfSCPYSLCGKLF 333

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*...
gi 46094072 485 PSISKLKRHYLIHTGQRPFGC--NICGKSFRQSAHLKRHEQTHNEKSP 530
Cdd:COG5048 334 SRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQQYKDL 381
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
42-66 9.71e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 9.71e-04
                          10        20
                  ....*....|....*....|....*
gi 46094072    42 LARHYLIHTGQKPFECDVCHKTFRQ 66
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
640-664 5.52e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.52e-03
                          10        20
                  ....*....|....*....|....*
gi 46094072   640 LERHYLIHAGQKPFECSVCGKTFRQ 664
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
185-530 7.18e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.29  E-value: 7.18e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46094072 185 QRPFKCVLCTKSFRQSTHLKIHQLTHSEERPFQCCFCQKGFKIQSKLLKHKQIHTRNKAFRALLLKKRRTESRPLPNKLN 264
Cdd:COG5048  31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSL 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46094072 265 ANQGGFENGEIGES------EENNPLDVHSIYIVPFQCPKCEKCFESEQILNEHSCFAARSGKIPSRFKRSYNYK-TIVK 337
Cdd:COG5048 111 SSSSSNSNDNNLLSshslppSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSlLISS 190

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46094072 338 KILAKLKRARSKKLDNFQSEKKVFKkSFLRNCDLISGEQSSEQTQRtfvgslgKHGTYKTIGNRKKKTLTLPFSWQNMGk 417
Cdd:COG5048 191 NVSTSIPSSSENSPLSSSYSIPSSS-SDQNLENSSSSLPLTTNSQL-------SPKSLLSQSPSSLSSSDSSSSASESP- 261

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46094072 418 nlkgilttENILSIDNSVNKKDLSICGSSGEEFFNNCEVLQCGFSVPRENIRTRHK-------------ICPCDKCEKVF 484
Cdd:COG5048 262 --------RSSLPTASSQSSSPNESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLrsvnhsgeslkpfSCPYSLCGKLF 333

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*...
gi 46094072 485 PSISKLKRHYLIHTGQRPFGC--NICGKSFRQSAHLKRHEQTHNEKSP 530
Cdd:COG5048 334 SRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQQYKDL 381
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 505-525 8.05e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 8.05e-03
                          10        20
                  ....*....|....*....|.
gi 46094072   505 CNICGKSFRQSAHLKRHEQTH 525
Cdd:pfam00096   3 CPDCGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
42-66 9.71e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 9.71e-04
                          10        20
                  ....*....|....*....|....*
gi 46094072    42 LARHYLIHTGQKPFECDVCHKTFRQ 66
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
640-664 5.52e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.52e-03
                          10        20
                  ....*....|....*....|....*
gi 46094072   640 LERHYLIHAGQKPFECSVCGKTFRQ 664
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
185-530 7.18e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.29  E-value: 7.18e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46094072 185 QRPFKCVLCTKSFRQSTHLKIHQLTHSEERPFQCCFCQKGFKIQSKLLKHKQIHTRNKAFRALLLKKRRTESRPLPNKLN 264
Cdd:COG5048  31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSL 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46094072 265 ANQGGFENGEIGES------EENNPLDVHSIYIVPFQCPKCEKCFESEQILNEHSCFAARSGKIPSRFKRSYNYK-TIVK 337
Cdd:COG5048 111 SSSSSNSNDNNLLSshslppSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSlLISS 190

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46094072 338 KILAKLKRARSKKLDNFQSEKKVFKkSFLRNCDLISGEQSSEQTQRtfvgslgKHGTYKTIGNRKKKTLTLPFSWQNMGk 417
Cdd:COG5048 191 NVSTSIPSSSENSPLSSSYSIPSSS-SDQNLENSSSSLPLTTNSQL-------SPKSLLSQSPSSLSSSDSSSSASESP- 261

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46094072 418 nlkgilttENILSIDNSVNKKDLSICGSSGEEFFNNCEVLQCGFSVPRENIRTRHK-------------ICPCDKCEKVF 484
Cdd:COG5048 262 --------RSSLPTASSQSSSPNESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLrsvnhsgeslkpfSCPYSLCGKLF 333

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*...
gi 46094072 485 PSISKLKRHYLIHTGQRPFGC--NICGKSFRQSAHLKRHEQTHNEKSP 530
Cdd:COG5048 334 SRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQQYKDL 381
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 55-77 7.74e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 7.74e-03
                          10        20
                  ....*....|....*....|...
gi 46094072    55 FECDVCHKTFRQLVHLERHQLTH 77
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 505-525 8.05e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 8.05e-03
                          10        20
                  ....*....|....*....|.
gi 46094072   505 CNICGKSFRQSAHLKRHEQTH 525
Cdd:pfam00096   3 CPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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