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Conserved domains on  [gi|156416005|ref|NP_054905|]
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COMM domain-containing protein 9 isoform 1 [Homo sapiens]

Protein Classification

COMM domain-containing protein 9( domain architecture ID 10140837)

COMM domain-containing protein 9 (COMMD9) may modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes, down-regulate activation of NF-kappa-B, and modulate Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits

Gene Ontology:  GO:0006814|GO:0042632
PubMed:  15799966
SCOP:  4005215

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Commd9 cd04757
COMM_Domain containing protein 9. The COMM Domain is found at the C-terminus of a variety of ...
 90-197 2.63e-62

COMM_Domain containing protein 9. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


:

Pssm-ID: 240105  Cd Length: 108  Bit Score: 188.54  E-value: 2.63e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156416005  90 FHQNLKNLLTKIILEHVSTWRTEAQANQISLPRLVDLDWRVDIKTSSDSISRMAVPTCLLQMKIQEDPSLCGDKPSISAV 169
Cdd:cd04757    1 FHSNLKNLLTKIILENRDKWRSEASENQISLPKLVDHDWRVDIKTSSDSLGRMAVPTCLLQMKIQEAPSLCGLLPPLSTL 80

                         90       100
                 ....*....|....*....|....*...
gi 156416005 170 TVELSKETLDTMLDGLGRIRDQLSAVAS 197
Cdd:cd04757   81 TMELSKETLDTMLDGLGRIRDQLSAVAQ 108
 
Name Accession Description Interval E-value
Commd9 cd04757
COMM_Domain containing protein 9. The COMM Domain is found at the C-terminus of a variety of ...
 90-197 2.63e-62

COMM_Domain containing protein 9. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240105  Cd Length: 108  Bit Score: 188.54  E-value: 2.63e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156416005  90 FHQNLKNLLTKIILEHVSTWRTEAQANQISLPRLVDLDWRVDIKTSSDSISRMAVPTCLLQMKIQEDPSLCGDKPSISAV 169
Cdd:cd04757    1 FHSNLKNLLTKIILENRDKWRSEASENQISLPKLVDHDWRVDIKTSSDSLGRMAVPTCLLQMKIQEAPSLCGLLPPLSTL 80

                         90       100
                 ....*....|....*....|....*...
gi 156416005 170 TVELSKETLDTMLDGLGRIRDQLSAVAS 197
Cdd:cd04757   81 TMELSKETLDTMLDGLGRIRDQLSAVAQ 108
COMM_domain pfam07258
COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a ...
 119-188 4.75e-15

COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a beta-sheet and an extreme C-terminal alpha- helix. The COMM domain containing proteins are about 200 residues in length and passed the C-terminal COMM domain.


Pssm-ID: 462125  Cd Length: 64  Bit Score: 66.42  E-value: 4.75e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156416005  119 SLPRLVDLDWRVDIKTSSDSISRMAVPTCLLQMKIQEdpslcgDKPSISAVTVELSKETLDTMLDGLGRI 188
Cdd:pfam07258   1 SLPQLVDLDWRLDVQLSSSSLSKVNEPVVLLELKLSD------GDGSSEEVTFELSKEQLQDLLNELEEA 64
 
Name Accession Description Interval E-value
Commd9 cd04757
COMM_Domain containing protein 9. The COMM Domain is found at the C-terminus of a variety of ...
 90-197 2.63e-62

COMM_Domain containing protein 9. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240105  Cd Length: 108  Bit Score: 188.54  E-value: 2.63e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156416005  90 FHQNLKNLLTKIILEHVSTWRTEAQANQISLPRLVDLDWRVDIKTSSDSISRMAVPTCLLQMKIQEDPSLCGDKPSISAV 169
Cdd:cd04757    1 FHSNLKNLLTKIILENRDKWRSEASENQISLPKLVDHDWRVDIKTSSDSLGRMAVPTCLLQMKIQEAPSLCGLLPPLSTL 80

                         90       100
                 ....*....|....*....|....*...
gi 156416005 170 TVELSKETLDTMLDGLGRIRDQLSAVAS 197
Cdd:cd04757   81 TMELSKETLDTMLDGLGRIRDQLSAVAQ 108
Commd cd04748
COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene ...
 97-192 6.96e-21

COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB. Murr1/Commd1 is a protein involved in copper homeostasis, which has also been identified as a regulator of the human delta epithelial sodium channel. HCaRG, a nuclear protein that might be involved in cell proliferation, is negatively regulated by extracellular calcium concentration, and its basal mRNA levels are higher in hypertensive animals.


Pssm-ID: 240096  Cd Length: 87  Bit Score: 82.36  E-value: 6.96e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156416005  97 LLTKIILEHVSTWRTEAQanqiSLPRLVDLDWRVDIKTSSDSISRMAVPTCLLQMKIQEdpslcGDKPSISAVTVELSKE 176
Cdd:cd04748    1 LLTENKAEIEELLSKQSL----SLPQLVDFDWRLDVQISSSSLAKVKQPTILVQLKLQV-----GDNNSSEKICFEMTKE 71

                         90
                 ....*....|....*.
gi 156416005 177 TLDTMLDGLGRIRDQL 192
Cdd:cd04748   72 ELQNFLNKLKKIKAQL 87
COMM_domain pfam07258
COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a ...
 119-188 4.75e-15

COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a beta-sheet and an extreme C-terminal alpha- helix. The COMM domain containing proteins are about 200 residues in length and passed the C-terminal COMM domain.


Pssm-ID: 462125  Cd Length: 64  Bit Score: 66.42  E-value: 4.75e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156416005  119 SLPRLVDLDWRVDIKTSSDSISRMAVPTCLLQMKIQEdpslcgDKPSISAVTVELSKETLDTMLDGLGRI 188
Cdd:pfam07258   1 SLPQLVDLDWRLDVQLSSSSLSKVNEPVVLLELKLSD------GDGSSEEVTFELSKEQLQDLLNELEEA 64
Commd2 cd04750
COMM_Domain containing protein 2. The COMM Domain is found at the C-terminus of a variety of ...
 50-158 2.11e-06

COMM_Domain containing protein 2. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240098 [Multi-domain]  Cd Length: 166  Bit Score: 45.77  E-value: 2.11e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156416005  50 LSVTQEEAEELLQALHRLTRLVAFRDLSSAEAILALFPENFHQNLKNLLTKIILEHVSTWRTEAQANQISLPRLVDLDWR 129
Cdd:cd04750   26 LEVEVETVQHGVEALVYLLIESTKLKLSERDFQDSIEFLGFSDDLNEILLQLYESNRKEIRNILKELSPDLPHYHNLEWR 105

                         90       100
                 ....*....|....*....|....*....
gi 156416005 130 VDIKTSSDSISRMAVPTCLLQMKIQEDPS 158
Cdd:cd04750  106 LDVQIASRSLRSQVKPVITMKLHLEDENK 134
Commd8 cd04756
COMM_Domain containing protein 8. The COMM Domain is found at the C-terminus of a variety of ...
 55-185 6.82e-06

COMM_Domain containing protein 8. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240104 [Multi-domain]  Cd Length: 176  Bit Score: 44.71  E-value: 6.82e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156416005  55 EEAEELLQALHRLTRLVAFRDLSSAEAILALfpenfhQNLKNLLTKIILEHVSTWRTE------AQANQISLPRLVDLDW 128
Cdd:cd04756   43 EEWTEVLESLATLFKQAVGKNSNDEEAKAQL------SDLSSSHQEALLKCVKSRKEEirqalvNKTNSISSAQLQDFDW 116

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 156416005 129 RVDIKTSSDSISRMAVPTCLLQMKIQEDPSLcgdKPsisaVTVELSKETLDTMLDGL 185
Cdd:cd04756  117 QLKLALSSDKLSSLQEPLLNLDLDVKENGIL---KP----VSIEMNKEELQNLISSL 166
Commd5_HCaRG cd04753
COMM_Domain containing protein 5, also called HCaRG (hypertension-related, calcium-regulated ...
 119-152 4.83e-04

COMM_Domain containing protein 5, also called HCaRG (hypertension-related, calcium-regulated gene). HCaRG is a nuclear protein that might be involved in cell proliferation; it is negatively regulated by extracellular calcium concentration, and its basal mRNA levels are higher in hypertensive animals. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240101  Cd Length: 110  Bit Score: 38.19  E-value: 4.83e-04
                         10        20        30
                 ....*....|....*....|....*....|....
gi 156416005 119 SLPRLVDLDWRVDIKTSSDSISRMAVPTCLLQMK 152
Cdd:cd04753   34 RLPHLEDFKWRVDVAISTSSLSRVLQPSILMEMK 67
Commd1_MURR1 cd04749
COMM_Domain containing protein 1, also called Murr1. Murr1/Commd1 is a protein involved in ...
 121-194 4.75e-03

COMM_Domain containing protein 1, also called Murr1. Murr1/Commd1 is a protein involved in copper homeostasis, which has also been identified as a regulator of the human delta epithelial sodium channel. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240097 [Multi-domain]  Cd Length: 174  Bit Score: 36.33  E-value: 4.75e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 156416005 121 PRLVDLDWRVDIKTSSDSISRMAVPTCLLQMKIQEDpslcGDKPSIsaVTVELSKETLDTMLDGLGRIRDQLSA 194
Cdd:cd04749  106 NSLRGLSWRVDLKTQSRHIAQINSPVAIVELELGKT----GQESEF--VCLEFDEAKVNRVLKQLAEIQESLDA 173
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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