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Conserved domains on  [gi|15826850|ref|NP_055081|]
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hematopoietic cell signal transducer isoform 1 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DAP10 super family cl06308
DAP10 membrane protein; This family consists of several mammalian DAP10 membrane proteins. In ...
 1-93 1.75e-34

DAP10 membrane protein; This family consists of several mammalian DAP10 membrane proteins. In activated mouse natural killer (NK) cells, the NKG2D receptor associates with two intracellular adaptors, DAP10 and DAP12, which trigger phosphatidyl inositol 3 kinase (PI3K) and Syk family protein tyrosine kinases, respectively. It has been suggested that the DAP10-PI3K pathway is sufficient to initiate NKG2D-mediated killing of target cells.


The actual alignment was detected with superfamily member pfam07213:

Pssm-ID: 284598  Cd Length: 79  Bit Score: 113.09  E-value: 1.75e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15826850    1 MIHLGHILFLLLLPVAAAQTTPGersslpafypgtsgSCSGCGSLSLPLLAGLVAADAVASLLIVGAVFLCARPRRSPAQ 80
Cdd:pfam07213  1 MIPPGHILFLLLLPVAAAQTTPG--------------SCSGCGPLSLPLLAGLVAADAVASLLIVGVVFVCARLRSRPAQ 66

                         90
                 ....*....|...
gi 15826850   81 EDGKVYINMPGRG 93
Cdd:pfam07213 67 EDGKVYINMPGRG 79
 
Name Accession Description Interval E-value
DAP10 pfam07213
DAP10 membrane protein; This family consists of several mammalian DAP10 membrane proteins. In ...
 1-93 1.75e-34

DAP10 membrane protein; This family consists of several mammalian DAP10 membrane proteins. In activated mouse natural killer (NK) cells, the NKG2D receptor associates with two intracellular adaptors, DAP10 and DAP12, which trigger phosphatidyl inositol 3 kinase (PI3K) and Syk family protein tyrosine kinases, respectively. It has been suggested that the DAP10-PI3K pathway is sufficient to initiate NKG2D-mediated killing of target cells.


Pssm-ID: 284598  Cd Length: 79  Bit Score: 113.09  E-value: 1.75e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15826850    1 MIHLGHILFLLLLPVAAAQTTPGersslpafypgtsgSCSGCGSLSLPLLAGLVAADAVASLLIVGAVFLCARPRRSPAQ 80
Cdd:pfam07213  1 MIPPGHILFLLLLPVAAAQTTPG--------------SCSGCGPLSLPLLAGLVAADAVASLLIVGVVFVCARLRSRPAQ 66

                         90
                 ....*....|...
gi 15826850   81 EDGKVYINMPGRG 93
Cdd:pfam07213 67 EDGKVYINMPGRG 79
 
Name Accession Description Interval E-value
DAP10 pfam07213
DAP10 membrane protein; This family consists of several mammalian DAP10 membrane proteins. In ...
 1-93 1.75e-34

DAP10 membrane protein; This family consists of several mammalian DAP10 membrane proteins. In activated mouse natural killer (NK) cells, the NKG2D receptor associates with two intracellular adaptors, DAP10 and DAP12, which trigger phosphatidyl inositol 3 kinase (PI3K) and Syk family protein tyrosine kinases, respectively. It has been suggested that the DAP10-PI3K pathway is sufficient to initiate NKG2D-mediated killing of target cells.


Pssm-ID: 284598  Cd Length: 79  Bit Score: 113.09  E-value: 1.75e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15826850    1 MIHLGHILFLLLLPVAAAQTTPGersslpafypgtsgSCSGCGSLSLPLLAGLVAADAVASLLIVGAVFLCARPRRSPAQ 80
Cdd:pfam07213  1 MIPPGHILFLLLLPVAAAQTTPG--------------SCSGCGPLSLPLLAGLVAADAVASLLIVGVVFVCARLRSRPAQ 66

                         90
                 ....*....|...
gi 15826850   81 EDGKVYINMPGRG 93
Cdd:pfam07213 67 EDGKVYINMPGRG 79
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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