BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166235167  195 KHCQAVLKQLNEQRLSNQFCDVTLLIEGEEYKAHKSVLSANSEYFRDLFIEKGAVSSHEAVVDLSGFCKASFLPLLEFAY 274
Cdd:cd18202     1 KHGQTVLDQLNQQRLNNQFCDVTLLIEGEEYKAHKSVLAANSEYFRELFIEKGAVSSHEAVVDLSGFCKSSFLPLLEFAY 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 166235167  275 TSVLSFDFCSMADVAILARHLFMSEVLEICESVHKLME 312
Cdd:cd18202    81 TSELTFDFCSMAEVAMLARHLFMNEVLEICESVHKQME 118

Zinc-finger double domain;

                           10        20
                   ....*....|....*....|....
gi 166235167   900 SLKRHVRTHTGERPYVCPVCSEAY 923
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSF 24

Zinc-finger double domain;

                           10        20
                   ....*....|....*....|....*
gi 166235167   780 DLRQHMNKHLGVKPFQCQFCDKCYS 804
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFK 25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166235167  195 KHCQAVLKQLNEQRLSNQFCDVTLLIEGEEYKAHKSVLSANSEYFRDLFIEKGAVSSHEAVVDLSGFCKASFLPLLEFAY 274
Cdd:cd18202     1 KHGQTVLDQLNQQRLNNQFCDVTLLIEGEEYKAHKSVLAANSEYFRELFIEKGAVSSHEAVVDLSGFCKSSFLPLLEFAY 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 166235167  275 TSVLSFDFCSMADVAILARHLFMSEVLEICESVHKLME 312
Cdd:cd18202    81 TSELTFDFCSMAEVAMLARHLFMNEVLEICESVHKQME 118

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166235167    215 DVTLLIEGEEYKAHKSVLSANSEYFRDLFiEKGAVSSHEAVVDLSGFCKASFLPLLEFAYTSVLSFDFCSMADVAILARH 294
Cdd:smart00225    1 DVTLVVGGKKFHAHKAVLAAHSPYFKALF-SSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADY 79

                            90
                    ....*....|..
gi 166235167    295 LFMSEVLEICES 306
Cdd:smart00225   80 LQIPGLVELCEE 91

hypothetical protein; Provisional

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166235167  195 KHCQAVLKQLNEQRLSNQFCDVTLLI-EGEEYKAHKSVLSANSEYFRDLFIEKGAVSSHEAVVDLSGFCKASFLPLLEFA 273
Cdd:PHA02713    7 KHNRRVVSNISNLLDDDILCDVIITIgDGEEIKAHKTILAAGSKYFRTLFTTPMIIRDLVTRVNLQMFDKDAVKNIVQYL 86

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 166235167  274 YTSVLSfdFCSMADVAILARHLFMSEVLEICESVHK 309
Cdd:PHA02713   87 YNRHIS--SMNVIDVLKCADYLLIDDLVTDCESYIK 120

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166235167  670 MLKHTGVKPHACQV--CGKTFIYKHGLKLHQ-SLHQSQKqfqcelcvksfVTKRSLQEHMSIHTGESK-YLCSVCGKSFH 745
Cdd:COG5189   341 MLKVKDGKPYKCPVegCNKKYKNQNGLKYHMlHGHQNQK-----------LHENPSPEKMNIFSAKDKpYRCEVCDKRYK 409

                          90
                  ....*....|..
gi 166235167  746 RGSGLSKHfKKH 757
Cdd:COG5189   410 NLNGLKYH-RKH 420

Zinc-finger double domain;

                           10        20
                   ....*....|....*....|....*
gi 166235167   780 DLRQHMNKHLGVKPFQCQFCDKCYS 804
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFK 25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166235167  195 KHCQAVLKQLNEQRLSNQFCDVTLLIEGEEYKAHKSVLSANSEYFRDLFIEKGAVSSHEAVVDLSGFCKASFLPLLEFAY 274
Cdd:cd18202     1 KHGQTVLDQLNQQRLNNQFCDVTLLIEGEEYKAHKSVLAANSEYFRELFIEKGAVSSHEAVVDLSGFCKSSFLPLLEFAY 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 166235167  275 TSVLSFDFCSMADVAILARHLFMSEVLEICESVHKLME 312
Cdd:cd18202    81 TSELTFDFCSMAEVAMLARHLFMNEVLEICESVHKQME 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166235167  196 HCQAVLKQLNEQRLSNQFCDVTLLIEGEEYKAHKSVLSANSEYFRDLFIEkGAVSSHEAVVDLSGFCKASFLPLLEFAYT 275
Cdd:cd18255     1 HSVTLLQGLNALRAKGQLLDVTLIADGQRFQAHKVVLASCSDYFRAMFTG-GMRESSQDEIELKGVSAKGLKHILDFAYT 79

                          90       100       110
                  ....*....|....*....|....*....|.
gi 166235167  276 SVLSFDFCSMADVAILARHLFMSEVLEICES 306
Cdd:cd18255    80 SELTLDLDCIQDVLGAAVHLQMLPVVELCEE 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166235167  194 PKHCQAVLKQLNEQRLSNQFCDVTLLIEGEEYKAHKSVLSANSEYFRDLFIEkGAVSSHEAVVDLSGFCKASFLPLLEFA 273
Cdd:cd18198     6 PDHSSEILSGLNEQRTQGLLCDVVILVQGREYRTHRSVLAACSQYFKKLFTS-GAVVDQQNVYEIDFVSPEALTALLEFA 84

                          90       100       110
                  ....*....|....*....|....*....|.
gi 166235167  274 YTSVLSFDFCSMADVAILARHLFMSEVLEIC 304
Cdd:cd18198    85 YTATLTVSTANVGDILSAARLLEIPCVSHVC 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166235167  194 PKHCQAVLKQLNEQRLSNQFCDVTLLIEGEEYKAHKSVLSANSEYFRDLFIEkGAVSSHEAVVDLSGFCKASFLPLLEFA 273
Cdd:cd18326     6 PDHSSDILSSLNEQRTQGLLCDVVILVEGREFPTHRSVLAACSQYFKKLFTS-GAVVDQQNVYEIDFVSAEALTALLDFA 84

                          90       100       110
                  ....*....|....*....|....*....|.
gi 166235167  274 YTSVLSFDFCSMADVAILARHLFMSEVLEIC 304
Cdd:cd18326    85 YTATLTVSTSNVGDILSAARLLEIPAVSHVC 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166235167  194 PKHCQAVLKQLNEQRLSNQFCDVTLLIEGEEYKAHKSVLSANSEYFRDLFIEKGAVSSHEAVVDLSGFCKASFLP----- 268
Cdd:cd18327     6 PEHSSELLSCLNEQRRAGLLCDLTIKTRGLEYRTHRAVLAACSLYFRKLFTGGGGGSGDLGAGGGQDVCELDFVGpealg 85

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 166235167  269 -LLEFAYTSVLSFDFCSMADVAILARHLFMSEVLEIC 304
Cdd:cd18327    86 aLLEFAYTATLTISSSNMREVLRAARLLEIPCVADAC 122

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166235167  195 KHCQAVLKQLNEQRLSNQFCDVTLLIEGEEYKAHKSVLSANSEYFRDLFieKGAVS-SHEAVVDLSGFCKASFLPLLEFA 273
Cdd:cd18256     2 KHASLILAQLNKLRGQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALF--AGGMSeSSKDVVQIHGVEPDIFHILLDFI 79

                          90       100       110
                  ....*....|....*....|....*....|.
gi 166235167  274 YTSVLSFDFCSMADVAILARHLFMSEVLEIC 304
Cdd:cd18256    80 YTGVVEVTVSNVQELLVAADMLQLTEVVEIC 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166235167  196 HCQAVLKQLNEQRLSNQFCDVTLLIEGEEYKAHKSVLSANSEYFRDLFIEKGavsSHEAVVDLSGFCKASFLPLLEFAYT 275
Cdd:cd18217     1 HCEQLLERLNKQREAGFLCDCTIVIGQFQFKAHRNVLAAFSEYFGAQYKDTE---DNIVFLDQSQVSADGFQKLLEFIYT 77

                          90       100       110
                  ....*....|....*....|....*....|
gi 166235167  276 SVLSFDFCSMADVAILARHLFMSEVLEICE 305
Cdd:cd18217    78 GNLNLDSWNVAEIHQAASYLGMEEVVAKCK 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166235167  196 HCQAVLKQLNEQRLSNQFCDVTLLIEGEEYKAHKSVLSANSEYFRDLFIEKGAVSSHEAVVDLSGFCKASFLPLLEFAYT 275
Cdd:cd18329     4 HQSRLLQQLDEQRKQELFCDCSILVEGQVFKAHRNVLFASSGYFKMLLSQNAKETGQPTVATFDVFSPDTFTIILDFVYS 83

                          90       100       110
                  ....*....|....*....|....*....|.
gi 166235167  276 SVLSFDFCSMADVAILARHLFMSEVLEICES 306
Cdd:cd18329    84 GKLSLTSQNVIEVMSAASYLQMTDVISVCKT 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166235167  194 PKHCQAVLKQLNEQRLSNQFCDVTLLIEGEEYKAHKSVLSANSEYFRDLFIeKGAVSSHEAVVDLSGFCKASFLPLLEFA 273
Cdd:cd18328     6 PNHSSEVLCSLNEQRHDGLLCDVVLIVQDQEYRTHRSVLAACSKYFKKLFT-AGTLADQPYVYEIDFVTPEALSAILEFA 84

                          90       100       110
                  ....*....|....*....|....*....|.
gi 166235167  274 YTSVLSFDFCSMADVAILARHLFMSEVLEIC 304
Cdd:cd18328    85 YTSTLTITTSNVKHILNAAQMLEIQCIINVC 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166235167  196 HCQAVLKQLNEQRLSNQFCDVTLLIEGEEYKAHKSVLSANSEYFRDLFIEKGAVSSHEAVVDLSGFCKASFLPLLEFAYT 275
Cdd:cd18199     1 HQSRLLGQLNEQRKQDFFCDCSIIVEGRIFKAHRNVLFASSGYFRMLLSHYIQDTGRPSTASFDVFSSDAFSIILDFVYS 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 166235167  276 SVLSFDFCSMADVAILARHLFMSEVLEICES 306
Cdd:cd18199    81 GKLSLTSQNVIEVMSAASYLQMTDVINVCKT 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166235167  193 SPKHCQAVLKQLNEQRLSNQFCDVTLLIEGEEYKAHKSVLSANSEYFRDLF----IEKGAVSSHEAVVDLSGFCKasflp 268
Cdd:cd18264     8 SKSHGEAVLSQYQSLRAEGFLCDVVLEAEGNEFPAHRSLLACSSDYFRALFkdytQESKARVIHLPVVSAAGLQR----- 82

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 166235167  269 LLEFAYTSVLSFDFCSMADVAILARHLFMSEVLEIC 304
Cdd:cd18264    83 VLDFIYTSWLSLSLDTLEDTLEAASYLQVTEAIGLC 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166235167  195 KHCQAVLKQLNEQRLSN-QFCDVTLLIEGEEYKAHKSVLSANSEYFRDLFIEKGAVSSHEAVVDLSGFCKASFLPLLEFA 273
Cdd:cd18207     8 QHSADMLHNLNQQRKSGgRFCDVLLRVGEESFPAHRAVLAACSEYFESVFSAQEGDGGTPRELEMHTISSKVFGDILDFA 87

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 166235167  274 YTSVLSFDFCSMADVAILARHLFMSEVLEICESVHK 309
Cdd:cd18207    88 YTSRIVVRLESFPELMTAAKFLLMRSVIDICQEVIK 123

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166235167  194 PKHCQAVLKQLNEQRLSNQFCDVTLLIEGEEYKAHKSVLSANSEYFRDLFiekgAVSSHEAVVDLSGFCKASFLPLLEFA 273
Cdd:cd18289    10 PNFGNTVLGCLNEQRLMGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLF----SGNSKSAFELPATVPPACFQQILSFC 85

                          90       100
                  ....*....|....*....|....*....
gi 166235167  274 YTSVLSFDFCSMADVAILARHLFMSEVLE 302
Cdd:cd18289    86 YTGKLTMAASEQLVVMYTAGFLQIQHIVE 114

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166235167    215 DVTLLIEGEEYKAHKSVLSANSEYFRDLFiEKGAVSSHEAVVDLSGFCKASFLPLLEFAYTSVLSFDFCSMADVAILARH 294
Cdd:smart00225    1 DVTLVVGGKKFHAHKAVLAAHSPYFKALF-SSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADY 79

                            90
                    ....*....|..
gi 166235167    295 LFMSEVLEICES 306
Cdd:smart00225   80 LQIPGLVELCEE 91

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166235167  196 HCQAVLKQLNEQRLSNQFCDVTLLIEGEEYKAHKSVLSANSEYFRDLFIEKGA-VSSHeaVVDLSGFCKASFLPLLEFAY 274
Cdd:cd18223     1 HSDTVLSCLNEQRIQGILCDVTIVVEDTKFKAHKNVLAASSLYFKNAFSSQEIwISSH--VLELPDLKAEVFAEILNFIY 78

                  ..
gi 166235167  275 TS 276
Cdd:cd18223    79 SS 80

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166235167  195 KHCQAVLKQLNEQRLSNQFCDVTLLIEGEEYKAHKSVLSANSEYFRDLFIEKGAVSSheAVVDLSGFCKA-SFLPLLEFA 273
Cdd:cd18215     1 RHASDVLLNLNRLRSRDILTDVVLVVGREQFRAHKTVLMACSGLFYSIFTDQLKNNV--SVINLDPEIEPeGFRILLDFM 78

                          90       100       110
                  ....*....|....*....|....*....|....
gi 166235167  274 YTSVLSFDFCSMADVAILARHLFMSEVLEICESV 307
Cdd:cd18215    79 YTSRLNLREGNIMAVMATAMYLQMEHVVDTCRKF 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166235167  195 KHCQAVLKQLNEQRLSNQFCDVTLLIEG----EEYKAHKSVLSANSEYFRDLFIeKGAVSSHEAVVDLSGFCKASFLPLL 270
Cdd:cd18248     3 DHTKEAFQIMNELRLSQQLCDVTLKVKYqdpkEEFMAHKVVLASSSPYFKAMFT-SGLRECGMEVVPIEGVHPCVMSRLI 81

                          90       100       110
                  ....*....|....*....|....*....|....
gi 166235167  271 EFAYTSVLSFDFCSMADVAILARHLFMSEVLEIC 304
Cdd:cd18248    82 EFAYTASISVGEKCVLHVLPGAVMYQMDSVVKAC 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 5 (ZBTB5); ZBTB5 is a POZ domain Kruppel-like zinc finger (POK) family transcription repressor of cell cycle arrest gene p21 and a potential proto-oncogene stimulating cell proliferation. ZBTB5 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166235167  194 PKHCQAVLKQLNEQRLSNQFCDVTLLIEGEEYKAHKSVLSANSEYFRDLF-IEKGAVSSHEAVVDLSGFCKASFLPLLEF 272
Cdd:cd18196     2 PGHFEQIFQQLNYQRLHGQLCDCVIVVGNRHFKAHRSVLAACSTHFRALFtVAEGDQTMNMIQLDSEVVTAEAFAALIDM 81

                          90       100       110
                  ....*....|....*....|....*....|...
gi 166235167  273 AYTSVLSFDFCSMADVAILARHLFMSEVLEICE 305
Cdd:cd18196    82 MYTSTLMLGESNVMDVLLAASHLHLNSVVKACK 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166235167  188 VVKRSSPKHCQAVLKQLNEQRLSNQFCDVTLLIEGEEYKAHKSVLSANSEYFRDLFIekGAVSSHEAVVDLSGFCKASFL 267
Cdd:cd18277     2 VFAYESSVHSTNVLLSLNDQRKKDVLCDVTILVEGQRFRAHRSVLAACSSYFHSRIV--GQADAELNITLPEEVTVKGFE 79

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 166235167  268 PLLEFAYTSVLSFDFCSMADVAILARHLFMSEVLEIC 304
Cdd:cd18277    80 PLIQFAYTAKLILSKDNVDEVCKCVEFLSVHNIEESC 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34); ZBTB34 acts as a transcriptional regulator. It downregulates specificity protein (Sp) transcription factors Sp1, Sp3, and Sp4 in pancreatic cancer cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166235167  194 PKHCQAVLKQLNEQRLSNQFCDVTLLIEGEEYKAHKSVLSANSEYFRDlfiekgavssHEAVVDLSGFCKA------SFL 267
Cdd:cd18220     6 PEYSNTVLSQLNELRLQGKLCDIIVHIQGQPFRAHKAVLAASSPYFRD----------HSALSTMSGLSISviknpnVFE 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 166235167  268 PLLEFAYTSVLSFDFCSMADVAILARHLFMSEVLEIC----ESVH 308
Cdd:cd18220    76 QLLSFCYTGRMSLQLKDVVSFLTAASFLQMQCVIDKCtqilESIH 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166235167  192 SSPKHCQAVLKQLNEQRLSNQFCDVTLLIEGEEYKAHKSVLSANSEYFRDLFiEKGAVSSHEAVVDLSGFCKASFLPLLE 271
Cdd:cd18265     2 SGPCHAERILQVLNAYRRSGTFTDVVLLVDGKDFPCHRATLSANSAYFRAMF-GGHLKESRQAVVEIQKVSAAAMEVLLD 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 166235167  272 FAYTSVLSFDFCSMADVAILARHLFMSEVLEIC 304
Cdd:cd18265    81 YMYGGGLRIQEDNVESVLEASDLLQVSKLREAC 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kaiso; Kaiso, also called zinc finger and BTB domain-containing protein 33 (ZBTB33), is a DNA methylation-dependent transcriptional repressor that binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3'. It also binds to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166235167  195 KHCQAVLKQLNEQRLSNQFCDVTLLIEGEEYKAHKSVLSANSEYFRDLFIEKGavssheAVVDLSgFCKAS-FLPLLEFA 273
Cdd:cd18219     3 QYSGSLLKSLNEQRGHGLFCDVTVIVEDRKFRAHKNILSASSTYFHQLFSVAG------QVVELN-FIRADiFAEILNYI 75

                  ....*
gi 166235167  274 YTSVL 278
Cdd:cd18219    76 YSSKI 80