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Conserved domains on  [gi|221625538|ref|NP_055244|]
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MORC family CW-type zinc finger protein 1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HATPase_MORC-like cd16931
Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger ...
 17-134 1.39e-66

Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains. In addition to the HATPase domain, MORC family proteins have a CW-type zinc finger domain containing four conserved cysteines and two conserved tryptophans, and coiled-coil domains at the carboxy-terminus. MORC1 has cross-species differential methylation in association with early life stress, and genome-wide association with major depressive disorder (MDD). MORC2 is involved in several nuclear processes, including transcription modulation and DNA damage repair, and exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY. MORC3 regulates p53, and is an antiviral factor which plays an important role during HSV-1 and HCMV infection, and is a positive regulator of influenza virus transcription. MORC4 is highly expressed in a subset of diffuse large B-cell lymphomas and has potential as a lymphoma biomarker.


:

Pssm-ID: 340408 [Multi-domain]  Cd Length: 118  Bit Score: 218.43  E-value: 1.39e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221625538  17 FIHANSTTHSFLFGALAELLDNARDAGAERLDVFSVDNEKLQGGFMLCFLDDGCGMSPEEASDIIYFGRSKKRLSTLKFI 96
Cdd:cd16931    1 FLHSNSTTHSWPFGAVAELVDNARDADATRLDIFIDDINLLRGGFMLSFLDDGNGMTPEEAHHMISFGFSDKRSDDHDHI 80

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 221625538  97 GQYGNGLKSGSMRIGKDFILFTKKEETMTCVFFSQTFC 134
Cdd:cd16931   81 GRYGNGFKSGSMRLGRDVIVFTKKDESQSCGLLSQTFL 118
Morc6_S5 super family cl39387
Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. ...
 236-437 5.41e-12

Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. Arabidopsis microrchidia (MORC) ATPase family proteins are conserved among plants and animals and are involved in transcriptional silencing. In Arabidopsis, MORC6/DMS11 was reported to function in the condensation of pericentromeric heterochromatin, thereby facilitating transcriptional silencing. Further studies demonstrate that MORC6 and its homologs MORC1 and MORC2 form a complex which associates with SUVH9, required for Pol V occupancy in the RdDM (RNA-directed DNA methylation) pathway.


The actual alignment was detected with superfamily member pfam17942:

Pssm-ID: 465579  Cd Length: 139  Bit Score: 64.10  E-value: 5.41e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221625538  236 SFRAYTSVLYFN--PWMRIFIQAKRVKTKHLCYCLYRPRKYLYVTSSFKGAfkdevkkaEEAVKIAESILKEAqikvnqc 313
Cdd:pfam17942   2 SLRAYASILYLRlpPNFQIILRGKKVEHHNIADDLKYPEKITYKPQVGGGK--------EVVVITTIGFLKEA------- 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221625538  314 drtslssakdvlqraledveaKQKNLkekqrelktartlslfYGVNVenrsqagmfiYSNNRLIKMHEKVGSQLKLKsll 393
Cdd:pfam17942  67 ---------------------PHINV----------------HGFNV----------YHKNRLIKPFWRVGNQAGSK--- 96

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 221625538  394 GAGVVGIvnipLEV--MEPSHNKQEFLNVQEYNHLLKVMGQYLVQY 437
Cdd:pfam17942  97 GRGVIGV----LEAnfIEPTHDKQDFERTSLYQRLEARLKQMLKEY 138
zf-CW pfam07496
CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four ...
 482-527 8.24e-12

CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by, and is predicted to be a "highly specialized mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including...chromatin methylation status and early embryonic development." Weak homology to pfam00628 further evidences these predictions (personal obs: C Yeats). Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteriztic of vertebrates, higher plants and other animals in which these domain is found.


:

Pssm-ID: 462181  Cd Length: 46  Bit Score: 60.79  E-value: 8.24e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 221625538  482 FIIQCDLCLKWRVLPSSTNyqEKEFFDIWICANNPNRLENSCHQVE 527
Cdd:pfam07496   1 YWVQCDSCLKWRRLPTEID--PYELPEPWYCSMNPDPKYNSCDAPE 44
 
Name Accession Description Interval E-value
HATPase_MORC-like cd16931
Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger ...
 17-134 1.39e-66

Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains. In addition to the HATPase domain, MORC family proteins have a CW-type zinc finger domain containing four conserved cysteines and two conserved tryptophans, and coiled-coil domains at the carboxy-terminus. MORC1 has cross-species differential methylation in association with early life stress, and genome-wide association with major depressive disorder (MDD). MORC2 is involved in several nuclear processes, including transcription modulation and DNA damage repair, and exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY. MORC3 regulates p53, and is an antiviral factor which plays an important role during HSV-1 and HCMV infection, and is a positive regulator of influenza virus transcription. MORC4 is highly expressed in a subset of diffuse large B-cell lymphomas and has potential as a lymphoma biomarker.


Pssm-ID: 340408 [Multi-domain]  Cd Length: 118  Bit Score: 218.43  E-value: 1.39e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221625538  17 FIHANSTTHSFLFGALAELLDNARDAGAERLDVFSVDNEKLQGGFMLCFLDDGCGMSPEEASDIIYFGRSKKRLSTLKFI 96
Cdd:cd16931    1 FLHSNSTTHSWPFGAVAELVDNARDADATRLDIFIDDINLLRGGFMLSFLDDGNGMTPEEAHHMISFGFSDKRSDDHDHI 80

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 221625538  97 GQYGNGLKSGSMRIGKDFILFTKKEETMTCVFFSQTFC 134
Cdd:cd16931   81 GRYGNGFKSGSMRLGRDVIVFTKKDESQSCGLLSQTFL 118
HATPase_c_3 pfam13589
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, ...
 28-160 2.90e-29

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 433332 [Multi-domain]  Cd Length: 135  Bit Score: 113.58  E-value: 2.90e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221625538   28 LFGALAELLDNARDAGAERLDVFSVDNEklQGGFMLCFLDDGCGMSPEEASDIIYFGRS-KKRLSTLKFIGQYGNGLKSG 106
Cdd:pfam13589   1 LEGALAELIDNSIDADATNIKIEVNKNR--GGGTEIVIEDDGHGMSPEELINALRLATSaKEAKRGSTDLGRYGIGLKLA 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 221625538  107 SMRIGKDFILFTKKEETMTCVFFSQTFCEEESlSEVVVPMPSWLIRTRESVTDD 160
Cdd:pfam13589  79 SLSLGAKLTVTSKKEGKSSTLTLDRDKISNEN-DWLLPLLTPAPIENFDELDKD 131
Morc6_S5 pfam17942
Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. ...
 236-437 5.41e-12

Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. Arabidopsis microrchidia (MORC) ATPase family proteins are conserved among plants and animals and are involved in transcriptional silencing. In Arabidopsis, MORC6/DMS11 was reported to function in the condensation of pericentromeric heterochromatin, thereby facilitating transcriptional silencing. Further studies demonstrate that MORC6 and its homologs MORC1 and MORC2 form a complex which associates with SUVH9, required for Pol V occupancy in the RdDM (RNA-directed DNA methylation) pathway.


Pssm-ID: 465579  Cd Length: 139  Bit Score: 64.10  E-value: 5.41e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221625538  236 SFRAYTSVLYFN--PWMRIFIQAKRVKTKHLCYCLYRPRKYLYVTSSFKGAfkdevkkaEEAVKIAESILKEAqikvnqc 313
Cdd:pfam17942   2 SLRAYASILYLRlpPNFQIILRGKKVEHHNIADDLKYPEKITYKPQVGGGK--------EVVVITTIGFLKEA------- 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221625538  314 drtslssakdvlqraledveaKQKNLkekqrelktartlslfYGVNVenrsqagmfiYSNNRLIKMHEKVGSQLKLKsll 393
Cdd:pfam17942  67 ---------------------PHINV----------------HGFNV----------YHKNRLIKPFWRVGNQAGSK--- 96

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 221625538  394 GAGVVGIvnipLEV--MEPSHNKQEFLNVQEYNHLLKVMGQYLVQY 437
Cdd:pfam17942  97 GRGVIGV----LEAnfIEPTHDKQDFERTSLYQRLEARLKQMLKEY 138
zf-CW pfam07496
CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four ...
 482-527 8.24e-12

CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by, and is predicted to be a "highly specialized mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including...chromatin methylation status and early embryonic development." Weak homology to pfam00628 further evidences these predictions (personal obs: C Yeats). Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteriztic of vertebrates, higher plants and other animals in which these domain is found.


Pssm-ID: 462181  Cd Length: 46  Bit Score: 60.79  E-value: 8.24e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 221625538  482 FIIQCDLCLKWRVLPSSTNyqEKEFFDIWICANNPNRLENSCHQVE 527
Cdd:pfam07496   1 YWVQCDSCLKWRRLPTEID--PYELPEPWYCSMNPDPKYNSCDAPE 44
mutl TIGR00585
DNA mismatch repair protein MutL; All proteins in this family for which the functions are ...
 31-77 7.46e-04

DNA mismatch repair protein MutL; All proteins in this family for which the functions are known are involved in the process of generalized mismatch repair. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273155 [Multi-domain]  Cd Length: 312  Bit Score: 42.63  E-value: 7.46e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 221625538   31 ALAELLDNARDAGAERLDVFSVDneklqGGF-MLCFLDDGCGMSPEEA 77
Cdd:TIGR00585  26 VVKELVENSLDAGATRIDVEIEE-----GGLkLIEVSDNGSGIDKEDL 68
MutL COG0323
DNA mismatch repair ATPase MutL [Replication, recombination and repair];
34-77 1.33e-03

DNA mismatch repair ATPase MutL [Replication, recombination and repair];


Pssm-ID: 440092 [Multi-domain]  Cd Length: 515  Bit Score: 42.34  E-value: 1.33e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 221625538  34 ELLDNARDAGAERLDVfsvdnEKLQGGFML-CFLDDGCGMSPEEA 77
Cdd:COG0323   30 ELVENAIDAGATRIEV-----EIEEGGKSLiRVTDNGCGMSPEDL 69
KpsE COG3524
Capsule polysaccharide export protein KpsE/RkpR [Cell wall/membrane/envelope biogenesis];
292-351 4.05e-03

Capsule polysaccharide export protein KpsE/RkpR [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442746 [Multi-domain]  Cd Length: 370  Bit Score: 40.60  E-value: 4.05e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 221625538 292 AEEAVKIAESILKEAQIKVNQcdrtsLS--SAKDVLQRALEDVEAKQKNLKEKQRELKTART 351
Cdd:COG3524  149 PEDAQAIAEALLAESEELVNQ-----LSerAREDAVRFAEEEVERAEERLRDAREALLAFRN 205
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 31-103 5.76e-03

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 37.63  E-value: 5.76e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 221625538    31 ALAELLDNARDAGAERLDVfSVDNEKLQGGFMLCFLDDGCGMSPEEASDI-IYFGRSKKRLSTlkfIGQYGNGL 103
Cdd:smart00387   9 VLSNLLDNAIKYTPEGGRI-TVTLERDGDHVEITVEDNGPGIPPEDLEKIfEPFFRTDKRSRK---IGGTGLGL 78
mutL PRK00095
DNA mismatch repair endonuclease MutL;
34-77 8.32e-03

DNA mismatch repair endonuclease MutL;


Pssm-ID: 234630 [Multi-domain]  Cd Length: 617  Bit Score: 39.81  E-value: 8.32e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 221625538  34 ELLDNARDAGAERLDVfsvdnEKLQGGfmlcfL------DDGCGMSPEEA 77
Cdd:PRK00095  29 ELVENALDAGATRIDI-----EIEEGG-----LklirvrDNGCGISKEDL 68
 
Name Accession Description Interval E-value
HATPase_MORC-like cd16931
Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger ...
 17-134 1.39e-66

Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains. In addition to the HATPase domain, MORC family proteins have a CW-type zinc finger domain containing four conserved cysteines and two conserved tryptophans, and coiled-coil domains at the carboxy-terminus. MORC1 has cross-species differential methylation in association with early life stress, and genome-wide association with major depressive disorder (MDD). MORC2 is involved in several nuclear processes, including transcription modulation and DNA damage repair, and exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY. MORC3 regulates p53, and is an antiviral factor which plays an important role during HSV-1 and HCMV infection, and is a positive regulator of influenza virus transcription. MORC4 is highly expressed in a subset of diffuse large B-cell lymphomas and has potential as a lymphoma biomarker.


Pssm-ID: 340408 [Multi-domain]  Cd Length: 118  Bit Score: 218.43  E-value: 1.39e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221625538  17 FIHANSTTHSFLFGALAELLDNARDAGAERLDVFSVDNEKLQGGFMLCFLDDGCGMSPEEASDIIYFGRSKKRLSTLKFI 96
Cdd:cd16931    1 FLHSNSTTHSWPFGAVAELVDNARDADATRLDIFIDDINLLRGGFMLSFLDDGNGMTPEEAHHMISFGFSDKRSDDHDHI 80

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 221625538  97 GQYGNGLKSGSMRIGKDFILFTKKEETMTCVFFSQTFC 134
Cdd:cd16931   81 GRYGNGFKSGSMRLGRDVIVFTKKDESQSCGLLSQTFL 118
HATPase_c_3 pfam13589
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, ...
 28-160 2.90e-29

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 433332 [Multi-domain]  Cd Length: 135  Bit Score: 113.58  E-value: 2.90e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221625538   28 LFGALAELLDNARDAGAERLDVFSVDNEklQGGFMLCFLDDGCGMSPEEASDIIYFGRS-KKRLSTLKFIGQYGNGLKSG 106
Cdd:pfam13589   1 LEGALAELIDNSIDADATNIKIEVNKNR--GGGTEIVIEDDGHGMSPEELINALRLATSaKEAKRGSTDLGRYGIGLKLA 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 221625538  107 SMRIGKDFILFTKKEETMTCVFFSQTFCEEESlSEVVVPMPSWLIRTRESVTDD 160
Cdd:pfam13589  79 SLSLGAKLTVTSKKEGKSSTLTLDRDKISNEN-DWLLPLLTPAPIENFDELDKD 131
Morc6_S5 pfam17942
Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. ...
 236-437 5.41e-12

Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. Arabidopsis microrchidia (MORC) ATPase family proteins are conserved among plants and animals and are involved in transcriptional silencing. In Arabidopsis, MORC6/DMS11 was reported to function in the condensation of pericentromeric heterochromatin, thereby facilitating transcriptional silencing. Further studies demonstrate that MORC6 and its homologs MORC1 and MORC2 form a complex which associates with SUVH9, required for Pol V occupancy in the RdDM (RNA-directed DNA methylation) pathway.


Pssm-ID: 465579  Cd Length: 139  Bit Score: 64.10  E-value: 5.41e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221625538  236 SFRAYTSVLYFN--PWMRIFIQAKRVKTKHLCYCLYRPRKYLYVTSSFKGAfkdevkkaEEAVKIAESILKEAqikvnqc 313
Cdd:pfam17942   2 SLRAYASILYLRlpPNFQIILRGKKVEHHNIADDLKYPEKITYKPQVGGGK--------EVVVITTIGFLKEA------- 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221625538  314 drtslssakdvlqraledveaKQKNLkekqrelktartlslfYGVNVenrsqagmfiYSNNRLIKMHEKVGSQLKLKsll 393
Cdd:pfam17942  67 ---------------------PHINV----------------HGFNV----------YHKNRLIKPFWRVGNQAGSK--- 96

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 221625538  394 GAGVVGIvnipLEV--MEPSHNKQEFLNVQEYNHLLKVMGQYLVQY 437
Cdd:pfam17942  97 GRGVIGV----LEAnfIEPTHDKQDFERTSLYQRLEARLKQMLKEY 138
zf-CW pfam07496
CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four ...
 482-527 8.24e-12

CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by, and is predicted to be a "highly specialized mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including...chromatin methylation status and early embryonic development." Weak homology to pfam00628 further evidences these predictions (personal obs: C Yeats). Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteriztic of vertebrates, higher plants and other animals in which these domain is found.


Pssm-ID: 462181  Cd Length: 46  Bit Score: 60.79  E-value: 8.24e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 221625538  482 FIIQCDLCLKWRVLPSSTNyqEKEFFDIWICANNPNRLENSCHQVE 527
Cdd:pfam07496   1 YWVQCDSCLKWRRLPTEID--PYELPEPWYCSMNPDPKYNSCDAPE 44
mutl TIGR00585
DNA mismatch repair protein MutL; All proteins in this family for which the functions are ...
 31-77 7.46e-04

DNA mismatch repair protein MutL; All proteins in this family for which the functions are known are involved in the process of generalized mismatch repair. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273155 [Multi-domain]  Cd Length: 312  Bit Score: 42.63  E-value: 7.46e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 221625538   31 ALAELLDNARDAGAERLDVFSVDneklqGGF-MLCFLDDGCGMSPEEA 77
Cdd:TIGR00585  26 VVKELVENSLDAGATRIDVEIEE-----GGLkLIEVSDNGSGIDKEDL 68
HATPase_MutL-MLH-PMS-like cd16926
Histidine kinase-like ATPase domain of DNA mismatch repair proteins Escherichia coli MutL, ...
 34-77 1.15e-03

Histidine kinase-like ATPase domain of DNA mismatch repair proteins Escherichia coli MutL, human MutL homologs (MLH/ PMS), and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of Escherichia coli MutL, human MLH1 (mutL homolog 1), human PMS1 (PMS1 homolog 1, mismatch repair system component), human MLH3 (mutL homolog 3), and human PMS2 (PMS1 homolog 2, mismatch repair system component). MutL homologs (MLH/PMS) participate in MMR (DNA mismatch repair), and in addition have role(s) in DNA damage signaling and suppression of homologous recombination (recombination between partially homologous parental DNAs). The primary role of MutL in MMR is to mediate protein-protein interactions during mismatch recognition and strand removal; a ternary complex is formed between MutS, MutL, and the mismatched DNA, which activates the MutH endonuclease.


Pssm-ID: 340403 [Multi-domain]  Cd Length: 188  Bit Score: 41.27  E-value: 1.15e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 221625538  34 ELLDNARDAGAERLDVFsVDNeklqGGfmLCFL---DDGCGMSPEEA 77
Cdd:cd16926   20 ELVENSIDAGATRIDVE-IEE----GG--LKLIrvtDNGSGISREDL 59
MutL COG0323
DNA mismatch repair ATPase MutL [Replication, recombination and repair];
34-77 1.33e-03

DNA mismatch repair ATPase MutL [Replication, recombination and repair];


Pssm-ID: 440092 [Multi-domain]  Cd Length: 515  Bit Score: 42.34  E-value: 1.33e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 221625538  34 ELLDNARDAGAERLDVfsvdnEKLQGGFML-CFLDDGCGMSPEEA 77
Cdd:COG0323   30 ELVENAIDAGATRIEV-----EIEEGGKSLiRVTDNGCGMSPEDL 69
KpsE COG3524
Capsule polysaccharide export protein KpsE/RkpR [Cell wall/membrane/envelope biogenesis];
292-351 4.05e-03

Capsule polysaccharide export protein KpsE/RkpR [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442746 [Multi-domain]  Cd Length: 370  Bit Score: 40.60  E-value: 4.05e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 221625538 292 AEEAVKIAESILKEAQIKVNQcdrtsLS--SAKDVLQRALEDVEAKQKNLKEKQRELKTART 351
Cdd:COG3524  149 PEDAQAIAEALLAESEELVNQ-----LSerAREDAVRFAEEEVERAEERLRDAREALLAFRN 205
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 31-103 5.76e-03

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 37.63  E-value: 5.76e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 221625538    31 ALAELLDNARDAGAERLDVfSVDNEKLQGGFMLCFLDDGCGMSPEEASDI-IYFGRSKKRLSTlkfIGQYGNGL 103
Cdd:smart00387   9 VLSNLLDNAIKYTPEGGRI-TVTLERDGDHVEITVEDNGPGIPPEDLEKIfEPFFRTDKRSRK---IGGTGLGL 78
mutL PRK00095
DNA mismatch repair endonuclease MutL;
34-77 8.32e-03

DNA mismatch repair endonuclease MutL;


Pssm-ID: 234630 [Multi-domain]  Cd Length: 617  Bit Score: 39.81  E-value: 8.32e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 221625538  34 ELLDNARDAGAERLDVfsvdnEKLQGGfmlcfL------DDGCGMSPEEA 77
Cdd:PRK00095  29 ELVENALDAGATRIDI-----EIEEGG-----LklirvrDNGCGISKEDL 68
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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