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Conserved domains on  [gi|20070252|ref|NP_055253|]
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interleukin-36 beta isoform 1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
beta-trefoil_IL36 cd23300
beta-trefoil domain found in the family of interleukin-36 (IL-36) and similar proteins; The ...
 8-160 5.82e-71

beta-trefoil domain found in the family of interleukin-36 (IL-36) and similar proteins; The IL-36 family includes three members, IL-36 alpha (also called FIL1 epsilon, or interleukin-1 epsilon, or IL-1 epsilon, or interleukin-1 family member 6, or IL-1F6), IL-36 beta (also called FIL1 eta, or interleukin-1 eta, or IL-1 eta, or interleukin-1 family member 8, or IL-1F8, or interleukin-1 homolog 2, or IL-1H2), and IL-36 gamma (also called IL-1-related protein 2, or IL-1RP2, or interleukin-1 epsilon, or IL-1 epsilon, or interleukin-1 family member 9, or IL-1F9, or interleukin-1 homolog 1, or IL-1H1). They act as cytokines that bind to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. They are parts of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; like the IL-1 system with which they share the co-receptor IL1RAP. They may be involved in skin inflammatory response by acting on keratinocytes, dendritic cells, and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. Members in this family contain a beta-trefoil domain, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


:

Pssm-ID: 466782  Cd Length: 148  Bit Score: 210.61  E-value: 5.82e-71
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070252   8 APKSYAIRDSRQMVWVLSGNSLIAAPLSRSIKPVTLHLIACRDTEFSDKEKGNMVYLGIKGKDLCLFCAEIQGKPTLQLK 87
Cdd:cd23300   1 KPSSRHIRDLNQQVWVLQGNTLIAVPRSDNVTPVTLALIPCRDTEFLEKDKGNPIYLGIKGPELCLFCEEIGGQPTLQLK 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 20070252  88 LQGSQDNIGKDT-CWKLVGIHTC-INLDVRESCFmgtLDQWGIGVGRKkwksSFQHHHLRKKDKDFSSMRTNIGM 160
Cdd:cd23300  81 EKNIMDLYNEPEaVKPFLFYHNQtGSTSTFESAA---YPGWFIASSSE----GGQPIILTKERGKTYNTNFYLDS 148
 
Name Accession Description Interval E-value
beta-trefoil_IL36 cd23300
beta-trefoil domain found in the family of interleukin-36 (IL-36) and similar proteins; The ...
 8-160 5.82e-71

beta-trefoil domain found in the family of interleukin-36 (IL-36) and similar proteins; The IL-36 family includes three members, IL-36 alpha (also called FIL1 epsilon, or interleukin-1 epsilon, or IL-1 epsilon, or interleukin-1 family member 6, or IL-1F6), IL-36 beta (also called FIL1 eta, or interleukin-1 eta, or IL-1 eta, or interleukin-1 family member 8, or IL-1F8, or interleukin-1 homolog 2, or IL-1H2), and IL-36 gamma (also called IL-1-related protein 2, or IL-1RP2, or interleukin-1 epsilon, or IL-1 epsilon, or interleukin-1 family member 9, or IL-1F9, or interleukin-1 homolog 1, or IL-1H1). They act as cytokines that bind to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. They are parts of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; like the IL-1 system with which they share the co-receptor IL1RAP. They may be involved in skin inflammatory response by acting on keratinocytes, dendritic cells, and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. Members in this family contain a beta-trefoil domain, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


Pssm-ID: 466782  Cd Length: 148  Bit Score: 210.61  E-value: 5.82e-71
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070252   8 APKSYAIRDSRQMVWVLSGNSLIAAPLSRSIKPVTLHLIACRDTEFSDKEKGNMVYLGIKGKDLCLFCAEIQGKPTLQLK 87
Cdd:cd23300   1 KPSSRHIRDLNQQVWVLQGNTLIAVPRSDNVTPVTLALIPCRDTEFLEKDKGNPIYLGIKGPELCLFCEEIGGQPTLQLK 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 20070252  88 LQGSQDNIGKDT-CWKLVGIHTC-INLDVRESCFmgtLDQWGIGVGRKkwksSFQHHHLRKKDKDFSSMRTNIGM 160
Cdd:cd23300  81 EKNIMDLYNEPEaVKPFLFYHNQtGSTSTFESAA---YPGWFIASSSE----GGQPIILTKERGKTYNTNFYLDS 148
IL1 smart00125
Interleukin-1 homologues; Cytokines with various biological functions. Interluekin 1 alpha and ...
 12-99 9.56e-05

Interleukin-1 homologues; Cytokines with various biological functions. Interluekin 1 alpha and beta are also known as hematopoietin and catabolin.


Pssm-ID: 128430  Cd Length: 147  Bit Score: 40.44  E-value: 9.56e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070252     12 YAIRDSRQMVWVLSG-NSLIAAPL-----SRSIK----PVTLHliacrdtEFSDKEKgnmVYLGIKGKDLCLFCAEIQGK 81
Cdd:smart00125   6 CRLNDANQKSLVLSNpQYLKALHLngqnlNQEVKfdmsFVQGE-------EDDSKIP---VTLGISGTNLYLSCVKKGDE 75

                           90
                   ....*....|....*...
gi 20070252     82 PTLQLKLQGSQDNIGKDT 99
Cdd:smart00125  76 PTLQLEMVDPPKYPKKEM 93
 
Name Accession Description Interval E-value
beta-trefoil_IL36 cd23300
beta-trefoil domain found in the family of interleukin-36 (IL-36) and similar proteins; The ...
 8-160 5.82e-71

beta-trefoil domain found in the family of interleukin-36 (IL-36) and similar proteins; The IL-36 family includes three members, IL-36 alpha (also called FIL1 epsilon, or interleukin-1 epsilon, or IL-1 epsilon, or interleukin-1 family member 6, or IL-1F6), IL-36 beta (also called FIL1 eta, or interleukin-1 eta, or IL-1 eta, or interleukin-1 family member 8, or IL-1F8, or interleukin-1 homolog 2, or IL-1H2), and IL-36 gamma (also called IL-1-related protein 2, or IL-1RP2, or interleukin-1 epsilon, or IL-1 epsilon, or interleukin-1 family member 9, or IL-1F9, or interleukin-1 homolog 1, or IL-1H1). They act as cytokines that bind to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. They are parts of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; like the IL-1 system with which they share the co-receptor IL1RAP. They may be involved in skin inflammatory response by acting on keratinocytes, dendritic cells, and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. Members in this family contain a beta-trefoil domain, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


Pssm-ID: 466782  Cd Length: 148  Bit Score: 210.61  E-value: 5.82e-71
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070252   8 APKSYAIRDSRQMVWVLSGNSLIAAPLSRSIKPVTLHLIACRDTEFSDKEKGNMVYLGIKGKDLCLFCAEIQGKPTLQLK 87
Cdd:cd23300   1 KPSSRHIRDLNQQVWVLQGNTLIAVPRSDNVTPVTLALIPCRDTEFLEKDKGNPIYLGIKGPELCLFCEEIGGQPTLQLK 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 20070252  88 LQGSQDNIGKDT-CWKLVGIHTC-INLDVRESCFmgtLDQWGIGVGRKkwksSFQHHHLRKKDKDFSSMRTNIGM 160
Cdd:cd23300  81 EKNIMDLYNEPEaVKPFLFYHNQtGSTSTFESAA---YPGWFIASSSE----GGQPIILTKERGKTYNTNFYLDS 148
beta-trefoil_IL37 cd23301
beta-trefoil domain found in interleukin-37 (IL-37) and similar proteins; IL-37, also called ...
 8-87 8.34e-14

beta-trefoil domain found in interleukin-37 (IL-37) and similar proteins; IL-37, also called FIL1 zeta, or IL-1X, or interleukin-1 family member 7, or IL-1F7, or interleukin-1 homolog 4, or IL-1H, or IL-1H4, or interleukin-1 zeta, or IL-1 zeta, or interleukin-1-related protein, or IL-1RP1, or interleukin-23, or IL-23, acts as a suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. It suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A, and IL1RN, but spares anti-inflammatory cytokines and inhibits dendritic cell activation. IL-37 contains a beta-trefoil domain, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


Pssm-ID: 466783  Cd Length: 151  Bit Score: 64.75  E-value: 8.34e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070252   8 APKSYAIRDSRQMVWVLSGNSLIAAPLSRSIKPVTLHLIACRDTEFSDkEKGNMVYLGIKGKDLCLFC--AEIQGKPTLQ 85
Cdd:cd23301   2 TPKKFIIRDTNQQVLVLDSGNLVAVPDKSYIKPETFYVLASHLRSASE-EKGNPIFLAVSKGELCLCCekVKGQKHPSLQ 80


                ..
gi 20070252  86 LK 87
Cdd:cd23301  81 LK 82
beta-trefoil_IL1 cd00100
beta-trefoil domain found in the interleukin-1 (IL-1) family of cytokines; The IL-1 family of ...
 9-98 6.70e-12

beta-trefoil domain found in the interleukin-1 (IL-1) family of cytokines; The IL-1 family of cytokines comprises 11 members, including 7 pro-inflammatory agonists (IL-1alpha, IL-1beta, IL-18, IL-33, IL-36alpha, IL-36beta, IL-36gamma) and 4 defined or putative antagonists (IL-1R antagonist (IL-1Ra), IL-36Ra, IL-37, and IL-38) exerting anti-inflammatory activities. These members can have complimentary or distinct biological functions. All family members share a common structure at the C-terminus, which is comprised by of a typical beta-trefoil fold consisting of 12-beta-strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


Pssm-ID: 466776  Cd Length: 145  Bit Score: 59.64  E-value: 6.70e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070252   9 PKSYAIRDSRQMVWVLSG-NSLIAAPLSRSIKPVTLHLIACRDTEFSDkEKGNMVYLGIKGKDLCLFCAEIQGKPTLQLK 87
Cdd:cd00100   2 KRNFVIRDSNDKSLYLRGnNELVAEDLSDVEKSAKITIYYYKSDSDED-FKGIPVVLNFTGTNCFLSCVKEGDKPSLQLE 80

                        90
                ....*....|.
gi 20070252  88 LQGSQDNIGKD 98
Cdd:cd00100  81 ECNKEELKNGD 91
beta-trefoil_IL1B cd23296
beta-trefoil domain found in interleukin-1 beta (IL-1 beta) and similar proteins; IL-1 beta, ...
 9-87 2.21e-09

beta-trefoil domain found in interleukin-1 beta (IL-1 beta) and similar proteins; IL-1 beta, also called catabolin, is a potent inflammatory cytokine that activates the inflammatory process. It was initially discovered as the major endogenous pyrogen. It induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. IL-1 beta promotes Th17 differentiation of T-cells and synergizes with IL12/interleukin-12 to induce IFN-gamma synthesis from T-helper 1 (Th1) cells. It plays a role in angiogenesis by inducing vascular endothelial growth factor (VEGF) production synergistically with tumor necrosis factor (TNF) and IL-6. IL-1 beta contains a C-terminal beta-trefoil domain, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


Pssm-ID: 466778  Cd Length: 150  Bit Score: 53.01  E-value: 2.21e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070252   9 PKSYAIRDSRQMVWVLSGNS-LIAAPL--SRSIKPVTLHLIACRDTEFSdkEKGNMVYLGIKGKDLCLFCAEIQGKPTLQ 85
Cdd:cd23296   4 SLSCTIRDSEQKSLVLSGPYqLVALHLqgPNSSQEVKLNMSFYRSPESN--GGKIPVALGIKGKNLYLSCVKKGDKPTLQ 81


                ..
gi 20070252  86 LK 87
Cdd:cd23296  82 LE 83
IL1 smart00125
Interleukin-1 homologues; Cytokines with various biological functions. Interluekin 1 alpha and ...
 12-99 9.56e-05

Interleukin-1 homologues; Cytokines with various biological functions. Interluekin 1 alpha and beta are also known as hematopoietin and catabolin.


Pssm-ID: 128430  Cd Length: 147  Bit Score: 40.44  E-value: 9.56e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070252     12 YAIRDSRQMVWVLSG-NSLIAAPL-----SRSIK----PVTLHliacrdtEFSDKEKgnmVYLGIKGKDLCLFCAEIQGK 81
Cdd:smart00125   6 CRLNDANQKSLVLSNpQYLKALHLngqnlNQEVKfdmsFVQGE-------EDDSKIP---VTLGISGTNLYLSCVKKGDE 75

                           90
                   ....*....|....*...
gi 20070252     82 PTLQLKLQGSQDNIGKDT 99
Cdd:smart00125  76 PTLQLEMVDPPKYPKKEM 93
beta-trefoil_IL36RA cd23303
beta-trefoil domain found in interleukin-36 receptor antagonist protein (IL-36RA) and similar ...
 9-86 5.23e-04

beta-trefoil domain found in interleukin-36 receptor antagonist protein (IL-36RA) and similar proteins; IL-36RA, also called FIL1 delta, or IL-1-related protein 3, or IL-1RP3, or interleukin-1 HY1, or IL-1HY1, or interleukin-1 delta, or IL-1 delta, or interleukin-1 family member 5, or IL-1F5, or interleukin-1 receptor antagonist homolog 1, or IL-1ra homolog 1, or interleukin-1-like protein 1, or IL-1L1, inhibits the activity of interleukin-36 (IL36 alpha,IL36 beta and IL36 gamma) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling. It is part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; like the IL-1 system with which it shares the coreceptor. It may play a role in skin inflammation, as well as in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. It may activate an anti-inflammatory signaling pathway by recruiting SIGIRR. IL-36RA contains a beta-trefoil domain, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


Pssm-ID: 466785  Cd Length: 146  Bit Score: 38.18  E-value: 5.23e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070252   9 PKSYAIRDSRQMVWVLSGNSLIAAPL--SRSIKPVTLHLIACRDTEfsdkEKGNMVYLGIKGKDLCLFCAEIQGkPTLQL 86
Cdd:cd23303   2 PLCFRMRDTALKVLYLHNNQLVAGGLhaGKNIKGEEISVVPNRFLD----RRLSPIILGVQGGSQCLSCGTGQE-PTLQL 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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