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Conserved domains on  [gi|7662112|ref|NP_055587|]
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CBP80/20-dependent translation initiation factor isoform 1 [Homo sapiens]

Protein Classification

MIF4G domain-containing protein( domain architecture ID 10501351)

MIF4G (middle domain of eukaryotic initiation factor 4G) domain-containing protein may contain multiple alpha-helical repeats

CATH:  1.25.40.180
Gene Ontology:  GO:0005515|GO:0003723
SCOP:  4000569

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MIF4G pfam02854
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). ...
376-577 4.86e-33

MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA.


:

Pssm-ID: 397130  Cd Length: 203  Bit Score: 125.55  E-value: 4.86e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662112    376 IEILNSMRNNSSDvdTKLTTFMEEAQNSTNSE-EMLGEIVRTIYQKAVSDRSFAFTAAKLCDKMALFMveGTKFRSLLLN 454
Cdd:pfam02854   1 LKKVKGILNKLSP--ENFEKLIKELLKLIMSDpELLKYLIELIFEKAVEEPNFIPAYARLCSGLNLRN--PTDFGIHLLN 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662112    455 MLQKDFTVR---EELQQQDVERWLGFITFLCEVFGTMRSSTGEPFRVLVCPIYTCLREllqSQDVKEDAVLCCSMELQST 531
Cdd:pfam02854  77 RLQEEFEKRfelEENEQGNRRRRLGLVRFLGELYKFGLLTEKILFECLKELLSSLTKE---DLKRDLFNLECLLTLLTTI 153
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 7662112    532 GRLLE-EQLPEMMTELLASARDKMLC---PSESMLTRSLLLEVIELHANS 577
Cdd:pfam02854 154 GKLLEnEKLPKLMDQFLDEIQKYVLSkddPKLSSRLRFMLQDLIELRKNK 203
 
Name Accession Description Interval E-value
MIF4G pfam02854
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). ...
376-577 4.86e-33

MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA.


Pssm-ID: 397130  Cd Length: 203  Bit Score: 125.55  E-value: 4.86e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662112    376 IEILNSMRNNSSDvdTKLTTFMEEAQNSTNSE-EMLGEIVRTIYQKAVSDRSFAFTAAKLCDKMALFMveGTKFRSLLLN 454
Cdd:pfam02854   1 LKKVKGILNKLSP--ENFEKLIKELLKLIMSDpELLKYLIELIFEKAVEEPNFIPAYARLCSGLNLRN--PTDFGIHLLN 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662112    455 MLQKDFTVR---EELQQQDVERWLGFITFLCEVFGTMRSSTGEPFRVLVCPIYTCLREllqSQDVKEDAVLCCSMELQST 531
Cdd:pfam02854  77 RLQEEFEKRfelEENEQGNRRRRLGLVRFLGELYKFGLLTEKILFECLKELLSSLTKE---DLKRDLFNLECLLTLLTTI 153
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 7662112    532 GRLLE-EQLPEMMTELLASARDKMLC---PSESMLTRSLLLEVIELHANS 577
Cdd:pfam02854 154 GKLLEnEKLPKLMDQFLDEIQKYVLSkddPKLSSRLRFMLQDLIELRKNK 203
MIF4G smart00543
Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The ...
376-576 1.66e-29

Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA. Ponting (TiBS) "Novel eIF4G domain homologues (in press)


Pssm-ID: 214713  Cd Length: 200  Bit Score: 115.54  E-value: 1.66e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662112     376 IEILNSMRNNSSDvdTKLTTFMEEAQNSTNS-EEMLGEIVRTIYQKAVSDRSFAFTAAKLCDKMALFMVEgtkFRSLLLN 454
Cdd:smart00543   1 EKKVKGLINKLSP--SNFESIIKELLKLNNSdKNLRKYILELIFEKAVEEPNFIPAYARLCALLNAKNPD---FGSLLLE 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662112     455 MLQKDFTVR-EELQQQDVERWLGFITFLCEVFGTMRSSTGEPFRVLVCPIYTCLRELLQsqdVKEDAVLCCSMELQSTGR 533
Cdd:smart00543  76 RLQEEFEKGlESEEESDKQRRLGLVRFLGELYNFQVLTSKIILELLKELLNDLTKLDPP---RSDFSVECLLSLLPTCGK 152
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*..
gi 7662112     534 LLE-EQLPEMMTELLASARDKMLCP---SESMLTRSLLLEVIELHAN 576
Cdd:smart00543 153 DLErEKSPKLLDEILERLQDYLLKKdktELSSRLRFMLELLIELRKN 199
 
Name Accession Description Interval E-value
MIF4G pfam02854
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). ...
376-577 4.86e-33

MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA.


Pssm-ID: 397130  Cd Length: 203  Bit Score: 125.55  E-value: 4.86e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662112    376 IEILNSMRNNSSDvdTKLTTFMEEAQNSTNSE-EMLGEIVRTIYQKAVSDRSFAFTAAKLCDKMALFMveGTKFRSLLLN 454
Cdd:pfam02854   1 LKKVKGILNKLSP--ENFEKLIKELLKLIMSDpELLKYLIELIFEKAVEEPNFIPAYARLCSGLNLRN--PTDFGIHLLN 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662112    455 MLQKDFTVR---EELQQQDVERWLGFITFLCEVFGTMRSSTGEPFRVLVCPIYTCLREllqSQDVKEDAVLCCSMELQST 531
Cdd:pfam02854  77 RLQEEFEKRfelEENEQGNRRRRLGLVRFLGELYKFGLLTEKILFECLKELLSSLTKE---DLKRDLFNLECLLTLLTTI 153
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 7662112    532 GRLLE-EQLPEMMTELLASARDKMLC---PSESMLTRSLLLEVIELHANS 577
Cdd:pfam02854 154 GKLLEnEKLPKLMDQFLDEIQKYVLSkddPKLSSRLRFMLQDLIELRKNK 203
MIF4G smart00543
Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The ...
376-576 1.66e-29

Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA. Ponting (TiBS) "Novel eIF4G domain homologues (in press)


Pssm-ID: 214713  Cd Length: 200  Bit Score: 115.54  E-value: 1.66e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662112     376 IEILNSMRNNSSDvdTKLTTFMEEAQNSTNS-EEMLGEIVRTIYQKAVSDRSFAFTAAKLCDKMALFMVEgtkFRSLLLN 454
Cdd:smart00543   1 EKKVKGLINKLSP--SNFESIIKELLKLNNSdKNLRKYILELIFEKAVEEPNFIPAYARLCALLNAKNPD---FGSLLLE 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662112     455 MLQKDFTVR-EELQQQDVERWLGFITFLCEVFGTMRSSTGEPFRVLVCPIYTCLRELLQsqdVKEDAVLCCSMELQSTGR 533
Cdd:smart00543  76 RLQEEFEKGlESEEESDKQRRLGLVRFLGELYNFQVLTSKIILELLKELLNDLTKLDPP---RSDFSVECLLSLLPTCGK 152
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*..
gi 7662112     534 LLE-EQLPEMMTELLASARDKMLCP---SESMLTRSLLLEVIELHAN 576
Cdd:smart00543 153 DLErEKSPKLLDEILERLQDYLLKKdktELSSRLRFMLELLIELRKN 199
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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