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Conserved domains on  [gi|20336290|ref|NP_055781|]
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ATP-dependent RNA helicase DHX30 isoform 2 [Homo sapiens]

Protein Classification

ATP-dependent RNA helicase( domain architecture ID 13388279)

DEAD/DEAH box containing ATP-dependent RNA helicase catalyzes the unwinding of RNA, similar to DEAH box protein 34 (DHX34) that is required for nonsense-mediated decay (NMD) degradation of mRNA transcripts containing premature stop codons

CATH:  3.40.50.300
EC:  3.6.4.13
Gene Ontology:  GO:0005524|GO:0003724|GO:0003676|GO:0016887|GO:0003723
PubMed:  34680866|19747077|22922795|20206133|21779027|20225155

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HrpA super family cl34328
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
387-919 1.19e-136

HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];


The actual alignment was detected with superfamily member COG1643:

Pssm-ID: 441249 [Multi-domain]  Cd Length: 836  Bit Score: 435.28  E-value: 1.19e-136
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290  387 PVWQEAPQLPVDPHRDTILNAIEQHPVVVISGDTGCGKTTRIPQLLLEryvtEGRGARCNVIITQPRRISAVSVAQRVSH 466
Cdd:COG1643    2 SLITYPPDLPVSAVLPELLAALRAHQVVVLAAPPGAGKTTQLPLALLE----LGWGAGGRIGMLEPRRLAARAAAERMAE 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290  467 ELGPSLRRNVGFQVRLESKPpSRGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQ-RLNPA 545
Cdd:COG1643   78 ELGEPVGETVGYRVRFEDKV-SAATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDLQpALRPD 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290  546 LRLVLMSATGDNERFSRYFGGCPVIKVPGFMYPVKEHYLEDilaklgkhqylhrhrhheSEDECALdLDLVTDLVLHIdA 625
Cdd:COG1643  157 LKLLVMSATLDAERFARLLGDAPVIESSGRTYPVEVRYRPL------------------PADERDL-EDAVADAVREA-L 216

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290  626 RGEPGGILCFLPGWQEIKGVQQRLQEALGMHeskYLILPVHSNIPMMDQKAIFQQPPVGVRKIVLATNIAETSITINDIV 705
Cdd:COG1643  217 AEEPGDILVFLPGEREIRRTAEALRGRLPPD---TEILPLYGRLSAAEQDRAFAPAPHGRRRIVLATNIAETSLTVPGIR 293

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290  706 HVVDSGLHKEERYDLKTKVSCLETVWVSRANVIQRRGRAGRCQSGFAYHLFPRSRLEKMVPFQVPEILRTPLENLVLQ-A 784
Cdd:COG1643  294 YVIDSGLARIPRYDPRSGVTRLPTERISQASANQRAGRAGRLAPGICYRLWSEEDFARRPAFTDPEILRADLASLILElA 373

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290  785 KIHMPEKTAVEFLskavDSPNIKAVDEAVILLQEIGVLDQREYLTTLGQRLAHISTDPRLAKAIVLAAIFRCLHPLLVVV 864
Cdd:COG1643  374 AWGLGDPEDLPFL----DPPPARAIADARALLQELGALDADGRLTPLGRALARLPLDPRLARMLLAAAELGCLREAAILA 449

                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 20336290  865 SCLT-RDPfssslqnraevdkvkalLSHDSGSDHLAFVRAVAGWEEVL----------RWQDRSSR 919
Cdd:COG1643  450 ALLSeRDP-----------------RRGAAGSDLLARLNLWRRLREQQreflsylrlrEWRDLARQ 498
OB_NTP_bind pfam07717
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ...
 976-1063 5.01e-07

Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.


:

Pssm-ID: 400182 [Multi-domain]  Cd Length: 82  Bit Score: 48.40  E-value: 5.01e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290    976 VKGVLMAGLYPNLiqvrqGKVTRQGKfkpnsvTYRTKSGN--ILLHKSTINREATRLRSRWLTYFMAVKSNgSVFVRDSS 1053
Cdd:pfam07717    1 LRAALAAGLYPNV-----ARRDPKGK------GYTTLSDNqrVFIHPSSVLFNEKTFPPEWVVYQELVETT-KVYIRTVT 68

                           90
                   ....*....|
gi 20336290   1054 QVHPLAVLLL 1063
Cdd:pfam07717   69 AISPEWLLLF 78
 
Name Accession Description Interval E-value
HrpA COG1643
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
387-919 1.19e-136

HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441249 [Multi-domain]  Cd Length: 836  Bit Score: 435.28  E-value: 1.19e-136
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290  387 PVWQEAPQLPVDPHRDTILNAIEQHPVVVISGDTGCGKTTRIPQLLLEryvtEGRGARCNVIITQPRRISAVSVAQRVSH 466
Cdd:COG1643    2 SLITYPPDLPVSAVLPELLAALRAHQVVVLAAPPGAGKTTQLPLALLE----LGWGAGGRIGMLEPRRLAARAAAERMAE 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290  467 ELGPSLRRNVGFQVRLESKPpSRGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQ-RLNPA 545
Cdd:COG1643   78 ELGEPVGETVGYRVRFEDKV-SAATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDLQpALRPD 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290  546 LRLVLMSATGDNERFSRYFGGCPVIKVPGFMYPVKEHYLEDilaklgkhqylhrhrhheSEDECALdLDLVTDLVLHIdA 625
Cdd:COG1643  157 LKLLVMSATLDAERFARLLGDAPVIESSGRTYPVEVRYRPL------------------PADERDL-EDAVADAVREA-L 216

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290  626 RGEPGGILCFLPGWQEIKGVQQRLQEALGMHeskYLILPVHSNIPMMDQKAIFQQPPVGVRKIVLATNIAETSITINDIV 705
Cdd:COG1643  217 AEEPGDILVFLPGEREIRRTAEALRGRLPPD---TEILPLYGRLSAAEQDRAFAPAPHGRRRIVLATNIAETSLTVPGIR 293

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290  706 HVVDSGLHKEERYDLKTKVSCLETVWVSRANVIQRRGRAGRCQSGFAYHLFPRSRLEKMVPFQVPEILRTPLENLVLQ-A 784
Cdd:COG1643  294 YVIDSGLARIPRYDPRSGVTRLPTERISQASANQRAGRAGRLAPGICYRLWSEEDFARRPAFTDPEILRADLASLILElA 373

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290  785 KIHMPEKTAVEFLskavDSPNIKAVDEAVILLQEIGVLDQREYLTTLGQRLAHISTDPRLAKAIVLAAIFRCLHPLLVVV 864
Cdd:COG1643  374 AWGLGDPEDLPFL----DPPPARAIADARALLQELGALDADGRLTPLGRALARLPLDPRLARMLLAAAELGCLREAAILA 449

                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 20336290  865 SCLT-RDPfssslqnraevdkvkalLSHDSGSDHLAFVRAVAGWEEVL----------RWQDRSSR 919
Cdd:COG1643  450 ALLSeRDP-----------------RRGAAGSDLLARLNLWRRLREQQreflsylrlrEWRDLARQ 498
DEXHc_DHX30 cd17976
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an ...
 395-572 4.37e-121

DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an important role in the assembly of the mitochondrial large ribosomal subunit. DHX30 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350734 [Multi-domain]  Cd Length: 178  Bit Score: 370.28  E-value: 4.37e-121
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290  395 LPVDPHRDTILNAIEQHPVVVISGDTGCGKTTRIPQLLLERYVTEGRGARCNVIITQPRRISAVSVAQRVSHELGPSLRR 474
Cdd:cd17976    1 LPVDSHKESILSAIEQNPVVVISGDTGCGKTTRIPQFILEDYVLRGRGARCNVVITQPRRISAVSVAQRVAHELGPNLRR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290  475 NVGFQVRLESKPPSRGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPALRLVLMSAT 554
Cdd:cd17976   81 NVGYQVRLESRPPPRGGALLFCTVGVLLKKLQSNPRLEGVSHVIVDEVHERDVNTDFLLILLKGVLQLNPELRVVLMSAT 160

                        170
                 ....*....|....*...
gi 20336290  555 GDNERFSRYFGGCPVIKV 572
Cdd:cd17976  161 GDNQRLSRYFGGCPVVRV 178
PRK11131 PRK11131
ATP-dependent RNA helicase HrpA; Provisional
 369-901 1.21e-83

ATP-dependent RNA helicase HrpA; Provisional


Pssm-ID: 182986 [Multi-domain]  Cd Length: 1294  Bit Score: 298.13  E-value: 1.21e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290   369 AEEVRLSQSLLELWRRRGPVWQEAPQLPVDPHRDTILNAIEQHPVVVISGDTGCGKTTRIPQLLLERyvteGRGARCNVI 448
Cdd:PRK11131   47 AKEIAQAAQRVLLREAARPEITYPENLPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICLEL----GRGVKGLIG 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290   449 ITQPRRISAVSVAQRVSHELGPSLRRNVGFQVRLESKPPSRGGALLFcTVGILLRKLQSNPSLEGVSHVIVDEVHERDVN 528
Cdd:PRK11131  123 HTQPRRLAARTVANRIAEELETELGGCVGYKVRFNDQVSDNTMVKLM-TDGILLAEIQQDRLLMQYDTIIIDEAHERSLN 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290   529 TDFLLILLKGLQRLNPALRLVLMSATGDNERFSRYFGGCPVIKVPGFMYPVKEHYledilaklgkhqylhRHRHHESEDE 608
Cdd:PRK11131  202 IDFILGYLKELLPRRPDLKVIITSATIDPERFSRHFNNAPIIEVSGRTYPVEVRY---------------RPIVEEADDT 266

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290   609 CALDLDLVTDLVLHIDARGePGGILCFLPGWQEIKGVQQRLQEALGMHESkylILPVHSNIPMMDQKAIFQqpPVGVRKI 688
Cdd:PRK11131  267 ERDQLQAIFDAVDELGREG-PGDILIFMSGEREIRDTADALNKLNLRHTE---ILPLYARLSNSEQNRVFQ--SHSGRRI 340

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290   689 VLATNIAETSITINDIVHVVDSGLHKEERYDLKTKVSCLETVWVSRANVIQRRGRAGRCQSGFAYHLFPRSRLEKMVPFQ 768
Cdd:PRK11131  341 VLATNVAETSLTVPGIKYVIDPGTARISRYSYRTKVQRLPIEPISQASANQRKGRCGRVSEGICIRLYSEDDFLSRPEFT 420

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290   769 VPEILRTPLENLVLQ-AKIHMPEKTAVEFlskaVDSPNIKAVDEAVILLQEIGVLDQRE-----YLTTLGQRLAHISTDP 842
Cdd:PRK11131  421 DPEILRTNLASVILQmTALGLGDIAAFPF----VEAPDKRNIQDGVRLLEELGAITTDEqasayKLTPLGRQLAQLPVDP 496

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290   843 RLAKAIVLAAIFRCLHPLLVVVSCLT-RDPFSSSLQNRAEVDKvKALLSHDSGSDHLAFV 901
Cdd:PRK11131  497 RLARMVLEAQKHGCVREVMIITSALSiQDPRERPMDKQQASDE-KHRRFADKESDFLAFV 555
DEXDc smart00487
DEAD-like helicases superfamily;
399-578 8.53e-25

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 103.34  E-value: 8.53e-25
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290     399 PHRDTILNAIEQHP-VVVISGDTGCGKTTRIPQLLLERYvteGRGARCNVIITQPRRISAVSVAQRVSHELGPSLRRNVG 477
Cdd:smart00487   11 PYQKEAIEALLSGLrDVILAAPTGSGKTLAALLPALEAL---KRGKGGRVLVLVPTRELAEQWAEELKKLGPSLGLKVVG 87

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290     478 FQVRLESKPP-----SRGGALLFCTVGILLRKLQSNP-SLEGVSHVIVDEVHERDvNTDFLLILLKGLQRLNPALRLVLM 551
Cdd:smart00487   88 LYGGDSKREQlrkleSGKTDILVTTPGRLLDLLENDKlSLSNVDLVILDEAHRLL-DGGFGDQLEKLLKLLPKNVQLLLL 166

                           170       180
                    ....*....|....*....|....*....
gi 20336290     552 SAT--GDNERFSRYFGGCPVIKVPGFMYP 578
Cdd:smart00487  167 SATppEEIENLLELFLNDPVFIDVGFTPL 195
HA2 pfam04408
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ...
 812-900 4.38e-17

Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.


Pssm-ID: 461295 [Multi-domain]  Cd Length: 104  Bit Score: 77.66  E-value: 4.38e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290    812 AVILLQEIGVLDQREYLTTLGQRLAHISTDPRLAKAIVLAAIFRCLHPLLVVVSCLT-RDPFSSSLQ------------- 877
Cdd:pfam04408    1 ALELLYYLGALDEDGELTPLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSvRDPFVQPNFldprsaakaarrr 80

                           90       100
                   ....*....|....*....|....
gi 20336290    878 NRAEVDKVKALLSH-DSGSDHLAF 900
Cdd:pfam04408   81 RRAADEKARAKFARlDLEGDHLTL 104
OB_NTP_bind pfam07717
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ...
 976-1063 5.01e-07

Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.


Pssm-ID: 400182 [Multi-domain]  Cd Length: 82  Bit Score: 48.40  E-value: 5.01e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290    976 VKGVLMAGLYPNLiqvrqGKVTRQGKfkpnsvTYRTKSGN--ILLHKSTINREATRLRSRWLTYFMAVKSNgSVFVRDSS 1053
Cdd:pfam07717    1 LRAALAAGLYPNV-----ARRDPKGK------GYTTLSDNqrVFIHPSSVLFNEKTFPPEWVVYQELVETT-KVYIRTVT 68

                           90
                   ....*....|
gi 20336290   1054 QVHPLAVLLL 1063
Cdd:pfam07717   69 AISPEWLLLF 78
 
Name Accession Description Interval E-value
HrpA COG1643
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
387-919 1.19e-136

HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441249 [Multi-domain]  Cd Length: 836  Bit Score: 435.28  E-value: 1.19e-136
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290  387 PVWQEAPQLPVDPHRDTILNAIEQHPVVVISGDTGCGKTTRIPQLLLEryvtEGRGARCNVIITQPRRISAVSVAQRVSH 466
Cdd:COG1643    2 SLITYPPDLPVSAVLPELLAALRAHQVVVLAAPPGAGKTTQLPLALLE----LGWGAGGRIGMLEPRRLAARAAAERMAE 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290  467 ELGPSLRRNVGFQVRLESKPpSRGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQ-RLNPA 545
Cdd:COG1643   78 ELGEPVGETVGYRVRFEDKV-SAATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDLQpALRPD 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290  546 LRLVLMSATGDNERFSRYFGGCPVIKVPGFMYPVKEHYLEDilaklgkhqylhrhrhheSEDECALdLDLVTDLVLHIdA 625
Cdd:COG1643  157 LKLLVMSATLDAERFARLLGDAPVIESSGRTYPVEVRYRPL------------------PADERDL-EDAVADAVREA-L 216

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290  626 RGEPGGILCFLPGWQEIKGVQQRLQEALGMHeskYLILPVHSNIPMMDQKAIFQQPPVGVRKIVLATNIAETSITINDIV 705
Cdd:COG1643  217 AEEPGDILVFLPGEREIRRTAEALRGRLPPD---TEILPLYGRLSAAEQDRAFAPAPHGRRRIVLATNIAETSLTVPGIR 293

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290  706 HVVDSGLHKEERYDLKTKVSCLETVWVSRANVIQRRGRAGRCQSGFAYHLFPRSRLEKMVPFQVPEILRTPLENLVLQ-A 784
Cdd:COG1643  294 YVIDSGLARIPRYDPRSGVTRLPTERISQASANQRAGRAGRLAPGICYRLWSEEDFARRPAFTDPEILRADLASLILElA 373

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290  785 KIHMPEKTAVEFLskavDSPNIKAVDEAVILLQEIGVLDQREYLTTLGQRLAHISTDPRLAKAIVLAAIFRCLHPLLVVV 864
Cdd:COG1643  374 AWGLGDPEDLPFL----DPPPARAIADARALLQELGALDADGRLTPLGRALARLPLDPRLARMLLAAAELGCLREAAILA 449

                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 20336290  865 SCLT-RDPfssslqnraevdkvkalLSHDSGSDHLAFVRAVAGWEEVL----------RWQDRSSR 919
Cdd:COG1643  450 ALLSeRDP-----------------RRGAAGSDLLARLNLWRRLREQQreflsylrlrEWRDLARQ 498
DEXHc_DHX30 cd17976
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an ...
 395-572 4.37e-121

DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an important role in the assembly of the mitochondrial large ribosomal subunit. DHX30 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350734 [Multi-domain]  Cd Length: 178  Bit Score: 370.28  E-value: 4.37e-121
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290  395 LPVDPHRDTILNAIEQHPVVVISGDTGCGKTTRIPQLLLERYVTEGRGARCNVIITQPRRISAVSVAQRVSHELGPSLRR 474
Cdd:cd17976    1 LPVDSHKESILSAIEQNPVVVISGDTGCGKTTRIPQFILEDYVLRGRGARCNVVITQPRRISAVSVAQRVAHELGPNLRR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290  475 NVGFQVRLESKPPSRGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPALRLVLMSAT 554
Cdd:cd17976   81 NVGYQVRLESRPPPRGGALLFCTVGVLLKKLQSNPRLEGVSHVIVDEVHERDVNTDFLLILLKGVLQLNPELRVVLMSAT 160

                        170
                 ....*....|....*...
gi 20336290  555 GDNERFSRYFGGCPVIKV 572
Cdd:cd17976  161 GDNQRLSRYFGGCPVVRV 178
PRK11131 PRK11131
ATP-dependent RNA helicase HrpA; Provisional
 369-901 1.21e-83

ATP-dependent RNA helicase HrpA; Provisional


Pssm-ID: 182986 [Multi-domain]  Cd Length: 1294  Bit Score: 298.13  E-value: 1.21e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290   369 AEEVRLSQSLLELWRRRGPVWQEAPQLPVDPHRDTILNAIEQHPVVVISGDTGCGKTTRIPQLLLERyvteGRGARCNVI 448
Cdd:PRK11131   47 AKEIAQAAQRVLLREAARPEITYPENLPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICLEL----GRGVKGLIG 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290   449 ITQPRRISAVSVAQRVSHELGPSLRRNVGFQVRLESKPPSRGGALLFcTVGILLRKLQSNPSLEGVSHVIVDEVHERDVN 528
Cdd:PRK11131  123 HTQPRRLAARTVANRIAEELETELGGCVGYKVRFNDQVSDNTMVKLM-TDGILLAEIQQDRLLMQYDTIIIDEAHERSLN 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290   529 TDFLLILLKGLQRLNPALRLVLMSATGDNERFSRYFGGCPVIKVPGFMYPVKEHYledilaklgkhqylhRHRHHESEDE 608
Cdd:PRK11131  202 IDFILGYLKELLPRRPDLKVIITSATIDPERFSRHFNNAPIIEVSGRTYPVEVRY---------------RPIVEEADDT 266

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290   609 CALDLDLVTDLVLHIDARGePGGILCFLPGWQEIKGVQQRLQEALGMHESkylILPVHSNIPMMDQKAIFQqpPVGVRKI 688
Cdd:PRK11131  267 ERDQLQAIFDAVDELGREG-PGDILIFMSGEREIRDTADALNKLNLRHTE---ILPLYARLSNSEQNRVFQ--SHSGRRI 340

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290   689 VLATNIAETSITINDIVHVVDSGLHKEERYDLKTKVSCLETVWVSRANVIQRRGRAGRCQSGFAYHLFPRSRLEKMVPFQ 768
Cdd:PRK11131  341 VLATNVAETSLTVPGIKYVIDPGTARISRYSYRTKVQRLPIEPISQASANQRKGRCGRVSEGICIRLYSEDDFLSRPEFT 420

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290   769 VPEILRTPLENLVLQ-AKIHMPEKTAVEFlskaVDSPNIKAVDEAVILLQEIGVLDQRE-----YLTTLGQRLAHISTDP 842
Cdd:PRK11131  421 DPEILRTNLASVILQmTALGLGDIAAFPF----VEAPDKRNIQDGVRLLEELGAITTDEqasayKLTPLGRQLAQLPVDP 496

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290   843 RLAKAIVLAAIFRCLHPLLVVVSCLT-RDPFSSSLQNRAEVDKvKALLSHDSGSDHLAFV 901
Cdd:PRK11131  497 RLARMVLEAQKHGCVREVMIITSALSiQDPRERPMDKQQASDE-KHRRFADKESDFLAFV 555
PRK11664 PRK11664
ATP-dependent RNA helicase HrpB; Provisional
 393-852 1.31e-83

ATP-dependent RNA helicase HrpB; Provisional


Pssm-ID: 236950 [Multi-domain]  Cd Length: 812  Bit Score: 290.29  E-value: 1.31e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290   393 PQLPVDPHRDTILNAIEQHPVVVISGDTGCGKTTRIPQLLLERYVTEGRgarcnVIITQPRRISAVSVAQRVSHELGPSL 472
Cdd:PRK11664    2 SSLPVAAVLPELLTALKTAPQVLLKAPTGAGKSTWLPLQLLQHGGINGK-----IIMLEPRRLAARNVAQRLAEQLGEKP 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290   473 RRNVGFQVRLESK--PPSRggaLLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQR-LNPALRLV 549
Cdd:PRK11664   77 GETVGYRMRAESKvgPNTR---LEVVTEGILTRMIQRDPELSGVGLVILDEFHERSLQADLALALLLDVQQgLRDDLKLL 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290   550 LMSATGDNERFSRYFGGCPVIKVPGFMYPVKEHYledilAKLGKHQYLhrhrhhesEDECAldlDLVTDLVlhidaRGEP 629
Cdd:PRK11664  154 IMSATLDNDRLQQLLPDAPVIVSEGRSFPVERRY-----QPLPAHQRF--------DEAVA---RATAELL-----RQES 212

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290   630 GGILCFLPGWQEIKGVQQRLQEALGmheSKYLILPVHSNIPMMDQ-KAIfQQPPVGVRKIVLATNIAETSITINDIVHVV 708
Cdd:PRK11664  213 GSLLLFLPGVGEIQRVQEQLASRVA---SDVLLCPLYGALSLAEQqKAI-LPAPAGRRKVVLATNIAETSLTIEGIRLVV 288

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290   709 DSGLHKEERYDLKTKVSCLETVWVSRANVIQRRGRAGRCQSGFAYHLFPRSRLEKMVPFQVPEILRTPLENLV---LQAK 785
Cdd:PRK11664  289 DSGLERVARFDPKTGLTRLVTQRISQASMTQRAGRAGRLEPGICLHLYSKEQAERAAAQSEPEILHSDLSGLLlelLQWG 368

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 20336290   786 IHMPEKTaveflsKAVDSPNIKAVDEAVILLQEIGVLDQREYLTTLGQRLAHISTDPRLAkAIVLAA 852
Cdd:PRK11664  369 CHDPAQL------SWLDQPPAAALAAAKRLLQQLGALDGQGRLTARGRKMAALGNDPRLA-AMLVAA 428
DEXHc_RHA-like cd17917
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) ...
 411-572 2.61e-81

DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438707 [Multi-domain]  Cd Length: 159  Bit Score: 262.40  E-value: 2.61e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290  411 HPVVVISGDTGCGKTTRIPQLLLERYVTegRGARCNVIITQPRRISAVSVAQRVSHELGPSLRRNVGFQVRLESKPpSRG 490
Cdd:cd17917    1 NQVVVIVGETGSGKTTQVPQFLLEDGLA--KGGKGRIVCTQPRRIAAISVAERVAEERGEKLGEEVGYQIRFESKT-SSK 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290  491 GALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPALRLVLMSATGDNERFSRYFGGCPVI 570
Cdd:cd17917   78 TRIKFCTDGILLRELLSDPLLSGYSHVILDEAHERSLDTDFLLGLLKDLLRKRPDLKVILMSATLDAEKFSSYFGGAPVI 157


                 ..
gi 20336290  571 KV 572
Cdd:cd17917  158 HI 159
SF2_C_RHA cd18791
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ...
 577-756 4.70e-79

C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350178 [Multi-domain]  Cd Length: 171  Bit Score: 256.31  E-value: 4.70e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290  577 YPVKEHYLEDILAKLGKHqylhrhrhheSEDECALDLDLVTDLVLHIDARGEPGGILCFLPGWQEIKGVQQRL-QEALGM 655
Cdd:cd18791    1 FPVEVYYLEDILELLGIS----------SEKEDPDYVDAAVRLILQIHRTEEPGDILVFLPGQEEIERLCELLrEELLSP 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290  656 HESKYLILPVHSNIPMMDQKAIFQQPPVGVRKIVLATNIAETSITINDIVHVVDSGLHKEERYDLKTKVSCLETVWVSRA 735
Cdd:cd18791   71 DLGKLLVLPLHSSLPPEEQQRVFEPPPPGVRKVVLATNIAETSITIPGVVYVIDSGLVKEKVYDPRTGLSSLVTVWISKA 150

                        170       180
                 ....*....|....*....|.
gi 20336290  736 NVIQRRGRAGRCQSGFAYHLF 756
Cdd:cd18791  151 SAEQRAGRAGRTRPGKCYRLY 171
DEXHc_DHX9 cd17972
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ...
 365-572 7.70e-72

DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ATP-dependent RNA helicase A or RHA and leukophysin or LKP) plays an important role in many cellular processes, including regulation of DNA replication, transcription, translation, microRNA biogenesis, RNA processing and transport, and maintenance of genomic stability. DHX9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350730 [Multi-domain]  Cd Length: 234  Bit Score: 238.97  E-value: 7.70e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290  365 PLLEAEEVRLSQSLL-ELWRRRG------PVWQEAPQLPVDPHRDTILNAIEQHPVVVISGDTGCGKTTRIPQLLLERYV 437
Cdd:cd17972   22 PLAFATPEQISMDLKnELMYQREqdhnlqQILQERELLPVKKFREEILEAISNNPVVIIRGATGCGKTTQVPQYILDDFI 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290  438 TEGRGARCNVIITQPRRISAVSVAQRVSHELGPSLRRNVGFQVRLESKPPSRGGALLFCTVGILLRKLQSnpSLEGVSHV 517
Cdd:cd17972  102 QNDRAAECNIVVTQPRRISAVSVAERVAFERGEEVGKSCGYSVRFESVLPRPHASILFCTVGVLLRKLEA--GIRGISHV 179

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 20336290  518 IVDEVHERDVNTDFLLILLKGLQRLNPALRLVLMSATGDNERFSRYFGGCPVIKV 572
Cdd:cd17972  180 IVDEIHERDINTDFLLVVLRDVVQAYPDLRVILMSATIDTSMFCEYFFNCPVIEV 234
DEXHc_DHX36 cd17981
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as ...
 395-572 1.55e-63

DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as G4-resolvase 1 or G4R1, MLE-like protein 1 and RNA helicase associated with AU-rich element or RHAU) unwinds a G4-quadruplex in human telomerase RNA. DHX36 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350739 [Multi-domain]  Cd Length: 180  Bit Score: 213.55  E-value: 1.55e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290  395 LPVDPHRDTILNAIEQHPVVVISGDTGCGKTTRIPQLLLERYVTEGRGARCNVIITQPRRISAVSVAQRVSHELGPS--L 472
Cdd:cd17981    1 LPSYGMKQEIINMIDNNQVTVISGETGCGKTTQVTQFILDDAIERGKGSSCRIVCTQPRRISAISVAERVAAERAEScgL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290  473 RRNVGFQVRLESKPPSRGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPALRLVLMS 552
Cdd:cd17981   81 GNSTGYQIRLESRKPRKQGSILYCTTGIVLQWLQSDPHLSNVSHLVLDEIHERNLQSDVLMGIVKDLLPFRSDLKVILMS 160

                        170       180
                 ....*....|....*....|
gi 20336290  553 ATGDNERFSRYFGGCPVIKV 572
Cdd:cd17981  161 ATLNAEKFSDYFNNCPMIHI 180
DEXHc_DHX57 cd17985
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the ...
 387-572 8.74e-62

DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350743 [Multi-domain]  Cd Length: 177  Bit Score: 208.54  E-value: 8.74e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290  387 PVWQEapqlpvdphRDTILNAIEQHPVVVISGDTGCGKTTRIPQLLLERYVTEGRGARCNVIITQPRRISAVSVAQRVSH 466
Cdd:cd17985    2 PAWQE---------RETILELLEKHQVLVISGMTGCGKTTQIPQFILDNSLQGPPLPVANIICTQPRRISAISVAERVAQ 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290  467 ELGPSLRRNVGFQVRLESKPpSRGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPAL 546
Cdd:cd17985   73 ERAERVGQSVGYQIRLESVK-SSATRLLYCTTGVLLRRLEGDPTLQGVTHVIVDEVHERTEESDFLLLVLKDLMVQRPDL 151

                        170       180
                 ....*....|....*....|....*.
gi 20336290  547 RLVLMSATGDNERFSRYFGGCPVIKV 572
Cdd:cd17985  152 KVILMSATLNAELFSDYFNSCPVIHI 177
DEXHc_DHX29 cd17975
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of ...
 395-572 1.12e-59

DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of the 43S pre-initiation complex involved in translation initiation of mRNAs with structured 5'-UTRs. DHX29 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350733 [Multi-domain]  Cd Length: 183  Bit Score: 202.45  E-value: 1.12e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290  395 LPVDPHRDTILNAIEQHPVVVISGDTGCGKTTRIPQLLLERYV-TEGRGARCNVIITQPRRISAVSVAQRVSHELG---- 469
Cdd:cd17975    1 LPVFKHRESILETLKRHRVVVVAGETGSGKSTQVPQFLLEDLLlNGGTAQKCNIVCTQPRRISAMSLATRVCEELGcesg 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290  470 PSLRRNV-GFQVRLESKPpSRGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPALRL 548
Cdd:cd17975   81 PGGKNSLcGYQIRMESRT-GEATRLLYCTTGVLLRKLQEDGLLSSISHIIVDEVHERSVQSDFLLIILKEILHKRSDLHL 159

                        170       180
                 ....*....|....*....|....
gi 20336290  549 VLMSATGDNERFSRYFGGCPVIKV 572
Cdd:cd17975  160 ILMSATVDCEKFSSYFTHCPILRI 183
DEXHc_YTHDC2 cd17987
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) ...
 395-572 5.42e-53

DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) regulates mRNA translation and stability via binding to N6-methyladenosine, a modified RNA nucleotide enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. YTHDC2 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350745 [Multi-domain]  Cd Length: 176  Bit Score: 183.11  E-value: 5.42e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290  395 LPVDPHRDTILNAIEQHPVVVISGDTGCGKTTRIPQLLLERyvTEGRGARCNVIITQPRRISAVSVAQRVSHELGPSLRR 474
Cdd:cd17987    1 LPVFEKQEQIVRIIKENKVVLIVGETGSGKTTQIPQFLLDD--CYANGIPCRIFCTQPRRLAAIAVAERVAAERGEKIGQ 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290  475 NVGFQVRLESKPpSRGGALLFCTVGILLRKLQSNPS-LEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPALRLVLMSA 553
Cdd:cd17987   79 TVGYQIRLESRV-SPKTLLTFCTNGVLLRTLMAGDSaLSTVTHVIVDEVHERDRFSDFLLTKLRDILQKHPNLKLILSSA 157

                        170
                 ....*....|....*....
gi 20336290  554 TGDNERFSRYFGGCPVIKV 572
Cdd:cd17987  158 ALDVNLFIRYFGSCPVIYI 176
DEXHc_TDRD9 cd17988
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also ...
 395-579 3.91e-51

DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also known as HIG-1or NET54 or C14orf75) is a part of the nuclear PIWI-interacting RNA (piRNA) pathway essential for transposon silencing and male fertility TDRD9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350746 [Multi-domain]  Cd Length: 180  Bit Score: 178.08  E-value: 3.91e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290  395 LPVDPHRDTILNAIEQHPVVVISGDTGCGKTTRIPQLLLERYVTegRGARCNVIITQPRRISAVSVAQRVSHELGPSLRR 474
Cdd:cd17988    1 LPIYAKREEILSLIEANSVVIIKGATGCGKTTQLPQFILDHYYK--RGKYCNIVVTQPRRIAAISIARRVSQEREWTLGS 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290  475 NVGFQVRLEsKPPSRGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPA-LRLVLMSA 553
Cdd:cd17988   79 LVGYQVGLE-RPASEETRLIYCTTGVLLQKLINNKTLTEYTHIILDEVHERDQELDFLLLVVRRLLRTNSRhVKIILMSA 157

                        170       180
                 ....*....|....*....|....*.
gi 20336290  554 TGDNERFSRYFGgcpVIKVPGFMYPV 579
Cdd:cd17988  158 TISCKEFADYFT---TPNNPAYVFEV 180
DEXHc_DHX33 cd17978
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA ...
 395-570 2.66e-50

DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA polymerase I transcription of the 47S precursor rRNA. DHX33 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438710 [Multi-domain]  Cd Length: 178  Bit Score: 175.62  E-value: 2.66e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290  395 LPVDPHRDTILNAIEQHPVVVISGDTGCGKTTRIPQLLLERYVTEGRgarcnVI-ITQPRRISAVSVAQRVSHELGPSLR 473
Cdd:cd17978    1 LPIYSARKRLLEELRKHDTVIIIGETGSGKTTQIPQYLYEAGFARGG-----MIgITQPRRVAAVSVAKRVAEEMGVELG 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290  474 RNVGFQVRLESKpPSRGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLN-----PALRL 548
Cdd:cd17978   76 QLVGYSVRFDDV-TSEETRIKYMTDGMLLREAIGDPLLSKYSVIILDEAHERTVHTDVLFGLVKSAQRRRkeqklSPLKV 154

                        170       180
                 ....*....|....*....|..
gi 20336290  549 VLMSATGDNERFSRYFGGCPVI 570
Cdd:cd17978  155 IIMSATLDADLFSEYFNGAPVL 176
DEXHc_DHX34 cd17979
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in ...
 395-572 6.21e-49

DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in the nonsense-mediated decay (NMD), a surveillance mechanism that degrades aberrant mRNAs. DHX34 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350737 [Multi-domain]  Cd Length: 170  Bit Score: 171.47  E-value: 6.21e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290  395 LPVDPHRDTILNAIEQHPVVVISGDTGCGKTTRIPQLLLERYVTegrgarcNVIITQPRRISAVSVAQRVSHELGPSLRR 474
Cdd:cd17979    1 LPIAQYREKIIELLKTHQVVIVAGDTGCGKSTQVPQYLLAAGFR-------HIACTQPRRIACISLAKRVAFESLNQYGS 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290  475 NVGFQVRLESkppSRGGA--LLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPALRLVLMS 552
Cdd:cd17979   74 KVAYQIRFER---TRTLAtkLLFLTEGLLLRQIQRDASLPQYNVLILDEVHERHLHGDFLLGVLRCLLRLRPDLKLILMS 150

                        170       180
                 ....*....|....*....|
gi 20336290  553 ATGDNERFSRYFGGCPVIKV 572
Cdd:cd17979  151 ATINIELFSGYFEGAPVVQV 170
DEXHc_DHX16 cd17974
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably ...
 395-572 3.13e-46

DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably involved in pre-mRNA splicing. DHX16 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350732 [Multi-domain]  Cd Length: 174  Bit Score: 163.83  E-value: 3.13e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290  395 LPVDPHRDTILNAIEQHPVVVISGDTGCGKTTRIPQLLLERYVTEGRGARCnviITQPRRISAVSVAQRVSHELGPSLRR 474
Cdd:cd17974    1 LPVYPYRDDLLAAVKEHQVLIIVGETGSGKTTQIPQYLHEAGYTKGGGKIG---CTQPRRVAAMSVAARVAEEMGVKLGN 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290  475 NVGFQVRLESKPPSRGgALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPALRLVLMSAT 554
Cdd:cd17974   78 EVGYSIRFEDCTSEKT-VLKYMTDGMLLREFLTEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPDLKLLISSAT 156

                        170
                 ....*....|....*...
gi 20336290  555 GDNERFSRYFGGCPVIKV 572
Cdd:cd17974  157 MDAEKFSAFFDDAPIFRI 174
DEXHc_DHX15 cd17973
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA ...
 388-572 9.90e-46

DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. DHX15 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438709 [Multi-domain]  Cd Length: 187  Bit Score: 162.97  E-value: 9.90e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290  388 VWQEAPQLPVDPHRDTILNAIEQHPVVVISGDTGCGKTTRIPQLLLERYVTEGRGARcnVIITQPRRISAVSVAQRVSHE 467
Cdd:cd17973    6 ILEKRRELPVWEQKEDFLKLLKNNQILVLVGETGSGKTTQIPQFVLDDELPHQPKKL--VACTQPRRVAAMSVAQRVAEE 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290  468 LGPSLRRNVGFQVRLESKPPSRGgALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPALR 547
Cdd:cd17973   84 MDVKLGEEVGYSIRFEDCSSAKT-ILKYMTDGMLLREAMSDPLLSRYSVIILDEAHERTLATDILMGLLKEVVRRRPDLK 162

                        170       180
                 ....*....|....*....|....*
gi 20336290  548 LVLMSATGDNERFSRYFGGCPVIKV 572
Cdd:cd17973  163 LIVMSATLDAGKFQKYFDNAPLLKV 187
DEXHc_HrpB cd17990
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA ...
 395-572 9.91e-46

DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpB belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438711 [Multi-domain]  Cd Length: 174  Bit Score: 162.50  E-value: 9.91e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290  395 LPVDPHRDTILNAIEQHPVVVISGDTGCGKTTRIPQLLLERYVTEGRgarcNVIITQPRRISAVSVAQRVSHELGPSLRR 474
Cdd:cd17990    1 LPIAAVLPALRAALDAGGQVVLEAPPGAGKTTRVPLALLAELWIAGG----KIIVLEPRRVAARAAARRLATLLGEAPGE 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290  475 NVGFQVRLESKPpSRGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQR-LNPALRLVLMSA 553
Cdd:cd17990   77 TVGYRVRGESRV-GRRTRVEVVTEGVLLRRLQRDPELSGVGAVILDEFHERSLDADLALALLLEVQQlLRDDLRLLAMSA 155

                        170
                 ....*....|....*....
gi 20336290  554 TGDNERFSRYFGGCPVIKV 572
Cdd:cd17990  156 TLDGDGLAALLPEAPVVES 174
DEXHc_HrpA cd17989
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA ...
 395-572 1.80e-45

DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpA belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350747 [Multi-domain]  Cd Length: 173  Bit Score: 161.47  E-value: 1.80e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290  395 LPVDPHRDTILNAIEQHPVVVISGDTGCGKTTRIPQLLLERyvteGRGARCNVIITQPRRISAVSVAQRVSHELGPSLRR 474
Cdd:cd17989    1 LPVSQKRDEIAKAIAENQVVIIAGETGSGKTTQLPKICLEL----GRGIRGLIGHTQPRRLAARSVAERIAEELKTELGG 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290  475 NVGFQVRLESKPPSRGGALLFcTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPALRLVLMSAT 554
Cdd:cd17989   77 AVGYKVRFTDQTSDETCVKLM-TDGILLAETQTDRYLRAYDTIIIDEAHERSLNIDFLLGYLKQLLPRRPDLKVIITSAT 155

                        170
                 ....*....|....*...
gi 20336290  555 GDNERFSRYFGGCPVIKV 572
Cdd:cd17989  156 IDAERFSRHFNNAPIIEV 173
DEXHc_DHX35 cd17980
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and ...
 395-564 3.24e-44

DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and seems to be associated with risk to thyroid cancers. It also has been shown to positively regulate poxviruses, such as Myxoma virus. DEAH-box helicase 35 (DHX35) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350738 [Multi-domain]  Cd Length: 185  Bit Score: 158.40  E-value: 3.24e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290  395 LPVDPHRDTILNAIEQHPVVVISGDTGCGKTTRIPQLLLER-YVTEGRgarcNVIITQPRRISAVSVAQRVSHELGPSLR 473
Cdd:cd17980    1 LPVFKLRNHILYLVENYQTIVIVGETGCGKSTQIPQYLAEAgWTAGGR----VVGCTQPRRVAAVTVAGRVAEEMGAVLG 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290  474 RNVGFQVRLESKPPSRGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPALRLVLMSA 553
Cdd:cd17980   77 HEVGYCIRFDDCTDPQATRIKFLTDGMLVREMMLDPLLTKYSVIMLDEAHERTLYTDILIGLLKKIQKKRGDLRLIVASA 156

                        170
                 ....*....|.
gi 20336290  554 TGDNERFSRYF 564
Cdd:cd17980  157 TLDAEKFRDFF 167
DEXHc_DHX37 cd17982
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the ...
 395-572 5.02e-44

DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the human nervous system and has been linked to schizophrenia. It also negatively regulates poxviruses such as Myxoma virus. DEAH-box helicase 37 (DHX37) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350740 [Multi-domain]  Cd Length: 191  Bit Score: 158.29  E-value: 5.02e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290  395 LPVDPHRDTILNAIEQHPVVVISGDTGCGKTTRIPQLLLERYVTEGRGARCNVI-ITQPRRISAVSVAQRVSHELGpSLR 473
Cdd:cd17982    1 LPILAEEQEIMEAINENPVVIICGETGSGKTTQVPQFLYEAGFGSPESDNPGMIgITQPRRVAAVSMAKRVAEELN-VFG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290  474 RNVGFQVRLESKpPSRGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILL-----------KGLQRL 542
Cdd:cd17982   80 KEVSYQIRYDST-VSENTKIKFMTDGVLLKEIQTDFLLRKYSVIIIDEAHERSVNTDILIGMLsrivplraklyLQDQTV 158

                        170       180       190
                 ....*....|....*....|....*....|....
gi 20336290  543 NPaLRLVLMSATGDNERFS---RYFGGCP-VIKV 572
Cdd:cd17982  159 KP-LKLVIMSATLRVEDFTenkLLFPRPPpVIKV 191
DEXHc_DHX8 cd17971
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as ...
 395-573 1.17e-42

DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22) acts late in the splicing of pre-mRNA and mediates the release of the spliced mRNA from spliceosomes. DHX8 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350729 [Multi-domain]  Cd Length: 179  Bit Score: 153.79  E-value: 1.17e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290  395 LPVDPHRDTILNAIEQHPVVVISGDTGCGKTTRIPQLLLEryvtEGRGARCNVIITQPRRISAVSVAQRVSHELGPSLRR 474
Cdd:cd17971    6 LPIYKLKEQLIQAVHDNQILVVIGETGSGKTTQITQYLAE----AGYTSRGKIGCTQPRRVAAMSVAKRVAEEFGCCLGQ 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290  475 NVGFQVRLESKPpSRGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPALRLVLMSAT 554
Cdd:cd17971   82 EVGYTIRFEDCT-SPETVIKYMTDGMLLRECLIDPDLSQYSVIMLDEAHERTIHTDVLFGLLKKTVQKRPDLKLIVTSAT 160

                        170
                 ....*....|....*....
gi 20336290  555 GDNERFSRYFGGCPVIKVP 573
Cdd:cd17971  161 LDAVKFSQYFYEAPIFTIP 179
DEXHc_DHX38 cd17983
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as ...
 395-572 2.29e-39

DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as PRP16) is involved in pre-mRNA splicing. DHX38 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350741 [Multi-domain]  Cd Length: 173  Bit Score: 144.14  E-value: 2.29e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290  395 LPVDPHRDTILNAIEQHPVVVISGDTGCGKTTRIPQLLLEryvtEGRGARCNVIITQPRRISAVSVAQRVSHELGPSLRR 474
Cdd:cd17983    1 LPIFAVRQELLNVIRDNNVVIVVGETGSGKTTQLTQYLHE----DGYTDYGMIGCTQPRRVAAMSVAKRVSEEMGVELGE 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290  475 NVGFQVRLESKPpSRGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPALRLVLMSAT 554
Cdd:cd17983   77 EVGYAIRFEDCT-SENTVIKYMTDGILLRESLRDPDLDKYSAIIMDEAHERSLNTDVLFGLLREVVARRRDLKLIVTSAT 155

                        170
                 ....*....|....*...
gi 20336290  555 GDNERFSRYFGGCPVIKV 572
Cdd:cd17983  156 MDADKFADFFGNVPIFTI 173
DEXHc_DHX40 cd17984
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the ...
 395-572 1.30e-38

DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350742 [Multi-domain]  Cd Length: 178  Bit Score: 142.30  E-value: 1.30e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290  395 LPVDPHRDTILNAIEQHPVVVISGDTGCGKTTRIPQLLLEryvtEGRGARCNVIITQPRRISAVSVAQRVSHELGPSLRR 474
Cdd:cd17984    1 LPIQKQRKKLVQAVRDNSFLIVTGNTGSGKTTQLPKYLYE----AGFSQHGMIGVTQPRRVAAISVAQRVAEEMKCTLGS 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290  475 NVGFQVRLESkPPSRGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPA-----LRLV 549
Cdd:cd17984   77 KVGYQVRFDD-CSSKETAIKYMTDGCLLRHILADPNLTKYSVIILDEAHERSLTTDILFGLLKKLFQEKSPnrkehLKVV 155

                        170       180
                 ....*....|....*....|...
gi 20336290  550 LMSATGDNERFSRYFGGCPVIKV 572
Cdd:cd17984  156 VMSATLELAKLSAFFGNCPVFDI 178
DEXHc_DHX32 cd17977
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the ...
 395-572 1.11e-27

DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350735 [Multi-domain]  Cd Length: 176  Bit Score: 110.69  E-value: 1.11e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290  395 LPVDPHRDTILNAIEQHPVVVISGDTGCGKTTRIPQLLLErYVTEGRGARCNVIITQPRRISAVSVAQRVSHELGPSLRR 474
Cdd:cd17977    1 LPVWEAKYEFMESLAHNQIVIVSGDAKTGKSSQIPQWCAE-YCLSAHYQHGVVVCTQVHKQTAVWLALRVADEMDVNIGH 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290  475 NVGFQVRLESKPPSRGgALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPALRLVLMSAT 554
Cdd:cd17977   80 EVGYVIPFENCCTNET-ILRYCTDDMLLREMMSDPLLESYGVIILDDAHERTVSTDVLLGLLKDVLLSRPELKLVIITCP 158

                        170
                 ....*....|....*...
gi 20336290  555 GDNERFSRYFGGCPVIKV 572
Cdd:cd17977  159 HLSSKLLSYYGNVPLIEV 176
DEXDc smart00487
DEAD-like helicases superfamily;
399-578 8.53e-25

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 103.34  E-value: 8.53e-25
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290     399 PHRDTILNAIEQHP-VVVISGDTGCGKTTRIPQLLLERYvteGRGARCNVIITQPRRISAVSVAQRVSHELGPSLRRNVG 477
Cdd:smart00487   11 PYQKEAIEALLSGLrDVILAAPTGSGKTLAALLPALEAL---KRGKGGRVLVLVPTRELAEQWAEELKKLGPSLGLKVVG 87

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290     478 FQVRLESKPP-----SRGGALLFCTVGILLRKLQSNP-SLEGVSHVIVDEVHERDvNTDFLLILLKGLQRLNPALRLVLM 551
Cdd:smart00487   88 LYGGDSKREQlrkleSGKTDILVTTPGRLLDLLENDKlSLSNVDLVILDEAHRLL-DGGFGDQLEKLLKLLPKNVQLLLL 166

                           170       180
                    ....*....|....*....|....*....
gi 20336290     552 SAT--GDNERFSRYFGGCPVIKVPGFMYP 578
Cdd:smart00487  167 SATppEEIENLLELFLNDPVFIDVGFTPL 195
DEXQc_DQX1 cd17986
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 ...
 395-572 8.72e-22

DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 (DQX1) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350744 [Multi-domain]  Cd Length: 177  Bit Score: 93.81  E-value: 8.72e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290  395 LPVDPHRDTILNAIEQHP-VVVISGDTGCGKTTRIPQLLLErYVTEGRGARCNVIITQPRRISAVSVAQRVSHELGPSLR 473
Cdd:cd17986    1 LPIWAAKFTFLEQLESPSgIVLVSGEPGSGKSTQVPQWCAE-FALSRGFQKGQVTVTQPHPLAARSLALRVADEMDLNLG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290  474 RNVGFQVRLES-KPPSRggALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPALRLVLMS 552
Cdd:cd17986   80 HEVGYSIPQEDcTGPNT--ILRFCWDRLLLQEMTSTPLLGAWGVVVLDEAQERSVASDSLLGLLKDVRLQRPELRVVVVT 157

                        170       180
                 ....*....|....*....|
gi 20336290  553 ATGDNERFSRYFGGCPVIKV 572
Cdd:cd17986  158 SPALEPKLRAFWGNPPVVHV 177
PHA02653 PHA02653
RNA helicase NPH-II; Provisional
 404-750 6.16e-19

RNA helicase NPH-II; Provisional


Pssm-ID: 177443 [Multi-domain]  Cd Length: 675  Bit Score: 92.35  E-value: 6.16e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290   404 ILNAIEQHPVVVISGDTGCGKTTRIPQLLLE-RYV---TEGRGARCNVIITQPRRISAVSVAQRVSHelGPSLRRNVGFQ 479
Cdd:PHA02653  172 IFEAWISRKPVVLTGGTGVGKTSQVPKLLLWfNYLfggFDNLDKIDPNFIERPIVLSLPRVALVRLH--SITLLKSLGFD 249

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290   480 VrLESKP----------------PSRGGaLLFCTvgillRKLQSNpSLEGVSHVIVDEVHERDVNTDFLL-ILLKGLQRL 542
Cdd:PHA02653  250 E-IDGSPislkygsipdelintnPKPYG-LVFST-----HKLTLN-KLFDYGTVIIDEVHEHDQIGDIIIaVARKHIDKI 321

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290   543 NpalRLVLMSAT--GDNERFSRYFGGCPVIKVPGF-MYPVKEHYLEDilaklgKHQYLHRHRHHESEDecaldldlvtDL 619
Cdd:PHA02653  322 R---SLFLMTATleDDRDRIKEFFPNPAFVHIPGGtLFPISEVYVKN------KYNPKNKRAYIEEEK----------KN 382

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290   620 VLHI--DARGEPG--GILcFLPGWQEIKGVQQRLQEALgmheSKYLILPVHSNIPMMDQ--KAIFQQPPVgvrKIVLATN 693
Cdd:PHA02653  383 IVTAlkKYTPPKGssGIV-FVASVSQCEEYKKYLEKRL----PIYDFYIIHGKVPNIDEilEKVYSSKNP---SIIISTP 454

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 20336290   694 IAETSITINDIVHVVDSG-LHKEERYDLKtkvscleTVWVSRANVIQRRGRAGRCQSG 750
Cdd:PHA02653  455 YLESSVTIRNATHVYDTGrVYVPEPFGGK-------EMFISKSMRTQRKGRVGRVSPG 505
HA2 pfam04408
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ...
 812-900 4.38e-17

Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.


Pssm-ID: 461295 [Multi-domain]  Cd Length: 104  Bit Score: 77.66  E-value: 4.38e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290    812 AVILLQEIGVLDQREYLTTLGQRLAHISTDPRLAKAIVLAAIFRCLHPLLVVVSCLT-RDPFSSSLQ------------- 877
Cdd:pfam04408    1 ALELLYYLGALDEDGELTPLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSvRDPFVQPNFldprsaakaarrr 80

                           90       100
                   ....*....|....*....|....
gi 20336290    878 NRAEVDKVKALLSH-DSGSDHLAF 900
Cdd:pfam04408   81 RRAADEKARAKFARlDLEGDHLTL 104
HA2 smart00847
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ...
 818-901 7.16e-17

Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.


Pssm-ID: 214852 [Multi-domain]  Cd Length: 82  Bit Score: 76.54  E-value: 7.16e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290     818 EIGVLDQREYLTTLGQRLAHISTDPRLAKAIVLAAIFRCLHPLLVVVSCLTRDPFSSSlQNRAEVDKVKALLSHDsGSDH 897
Cdd:smart00847    1 ELGALDDDGRLTPLGRKMAELPLDPRLAKMLLAAAEFGCLDEILTIVAMLSVGDPRPK-EKREDADAARRRFADP-ESDH 78


                    ....
gi 20336290     898 LAFV 901
Cdd:smart00847   79 LTLL 82
SF2-N cd00046
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ...
 411-554 1.75e-16

N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.


Pssm-ID: 350668 [Multi-domain]  Cd Length: 146  Bit Score: 77.44  E-value: 1.75e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290  411 HPVVVISGDTGCGKTTRIPQLLLERYVTegrgARCNVIITQPRRISAVSVAQRVSHELGPSLRrnVGFQVRLESKPPSRG 490
Cdd:cd00046    1 GENVLITAPTGSGKTLAALLAALLLLLK----KGKKVLVLVPTKALALQTAERLRELFGPGIR--VAVLVGGSSAEEREK 74

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 20336290  491 GA-----LLFCTVGILLRKLQSN--PSLEGVSHVIVDEVHERDVNTDFLLIL-LKGLQRLNPALRLVLMSAT 554
Cdd:cd00046   75 NKlgdadIIIATPDMLLNLLLREdrLFLKDLKLIIVDEAHALLIDSRGALILdLAVRKAGLKNAQVILLSAT 146
HELICc smart00490
helicase superfamily c-terminal domain;
647-746 4.71e-13

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 65.70  E-value: 4.71e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290     647 QRLQEALGMHesKYLILPVHSNIPMMDQKAIFQQPPVGVRKIVLATNIAETSITINDIVHVVDSGLhkeerydlktkvsc 726
Cdd:smart00490    1 EELAELLKEL--GIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDL-------------- 64

                            90       100
                    ....*....|....*....|
gi 20336290     727 letvWVSRANVIQRRGRAGR 746
Cdd:smart00490   65 ----PWSPASYIQRIGRAGR 80
DEAD pfam00270
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ...
 414-554 1.17e-10

DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.


Pssm-ID: 425570 [Multi-domain]  Cd Length: 165  Bit Score: 61.49  E-value: 1.17e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290    414 VVISGDTGCGKTT--RIPqlLLERYVTEGRGARcnVIITQPRRISA---VSVAQRVSHELGPSLRRNVGFQVRLESKPPS 488
Cdd:pfam00270   17 VLVQAPTGSGKTLafLLP--ALEALDKLDNGPQ--ALVLAPTRELAeqiYEELKKLGKGLGLKVASLLGGDSRKEQLEKL 92

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 20336290    489 RGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNtDFLLILLKGLQRLNPALRLVLMSAT 554
Cdd:pfam00270   93 KGPDILVGTPGRLLDLLQERKLLKNLKLLVLDEAHRLLDM-GFGPDLEEILRRLPKKRQILLLSAT 157
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
 618-746 1.19e-10

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 59.53  E-value: 1.19e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290    618 DLVLHIDARGEPGGILCFLPGWQEIKGvqQRLQEALGmheskYLILPVHSNIPMMDQKAIFQQPPVGVRKIVLATNIAET 697
Cdd:pfam00271    4 EALLELLKKERGGKVLIFSQTKKTLEA--ELLLEKEG-----IKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAER 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 20336290    698 SITINDIVHVVDSGLHKeerydlktkvscletvwvSRANVIQRRGRAGR 746
Cdd:pfam00271   77 GLDLPDVDLVINYDLPW------------------NPASYIQRIGRAGR 107
OB_NTP_bind pfam07717
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ...
 976-1063 5.01e-07

Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.


Pssm-ID: 400182 [Multi-domain]  Cd Length: 82  Bit Score: 48.40  E-value: 5.01e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290    976 VKGVLMAGLYPNLiqvrqGKVTRQGKfkpnsvTYRTKSGN--ILLHKSTINREATRLRSRWLTYFMAVKSNgSVFVRDSS 1053
Cdd:pfam07717    1 LRAALAAGLYPNV-----ARRDPKGK------GYTTLSDNqrVFIHPSSVLFNEKTFPPEWVVYQELVETT-KVYIRTVT 68

                           90
                   ....*....|
gi 20336290   1054 QVHPLAVLLL 1063
Cdd:pfam07717   69 AISPEWLLLF 78
DEXHc_Ski2 cd17921
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ...
 414-571 7.01e-05

DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350679 [Multi-domain]  Cd Length: 181  Bit Score: 44.95  E-value: 7.01e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290  414 VVISGDTGCGKTTrIPQLLLERYVTEGRGarcNVIITQPRRisAVS--VAQRVSHELGPSlrrnvGFQVRL------ESK 485
Cdd:cd17921   20 VLVSAPTSSGKTL-IAELAILRALATSGG---KAVYIAPTR--ALVnqKEADLRERFGPL-----GKNVGLltgdpsVNK 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290  486 PPSRGGALLFCT---VGILLRKLqSNPSLEGVSHVIVDEVH-----ERDVntdFLLILLKGLQRLNPALRLVLMSATGDN 557
Cdd:cd17921   89 LLLAEADILVATpekLDLLLRNG-GERLIQDVRLVVVDEAHligdgERGV---VLELLLSRLLRINKNARFVGLSATLPN 164

                        170
                 ....*....|....*
gi 20336290  558 -ERFSRYFGGCPVIK 571
Cdd:cd17921  165 aEDLAEWLGVEDLIR 179
SF2_C cd18785
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ...
 687-757 4.60e-03

C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350172 [Multi-domain]  Cd Length: 77  Bit Score: 36.91  E-value: 4.60e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 20336290  687 KIVLATNIAETSITINDIVHVVdsglhkeerydlktkvscLETVWVSRANVIQRRGRAGR-CQSGFAYHLFP 757
Cdd:cd18785   24 EILVATNVLGEGIDVPSLDTVI------------------FFDPPSSAASYIQRVGRAGRgGKDEGEVILFV 77
SSL2 COG1061
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
402-680 8.79e-03

Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];


Pssm-ID: 440681 [Multi-domain]  Cd Length: 566  Bit Score: 40.01  E-value: 8.79e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290  402 DTILNAIEQ-HPVVVISGDTGCGKTtRIPQLLLERYVTEGRgarcnVIITQPRRISAVSVAQRVSHELGPSLRRnvgfqv 480
Cdd:COG1061   90 EALLAALERgGGRGLVVAPTGTGKT-VLALALAAELLRGKR-----VLVLVPRRELLEQWAEELRRFLGDPLAG------ 157

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290  481 rleSKPPSRGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHErdVNTDFlliLLKGLQRLNPALRLvLMSAT-----G 555
Cdd:COG1061  158 ---GGKKDSDAPITVATYQSLARRAHLDELGDRFGLVIIDEAHH--AGAPS---YRRILEAFPAAYRL-GLTATpfrsdG 228

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290  556 DNERFSRYFGgcPVIKVP-------GFmypVKEHYLEDILAKLGKHQYLHRHRHHESEDECALDLDLVTDLVLHI-DARG 627
Cdd:COG1061  229 REILLFLFDG--IVYEYSlkeaiedGY---LAPPEYYGIRVDLTDERAEYDALSERLREALAADAERKDKILRELlREHP 303

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 20336290  628 EPGGILCFLPGWQEIKGVQQRLQEAlgmhesKYLILPVHSNIPMMDQKAIFQQ 680
Cdd:COG1061  304 DDRKTLVFCSSVDHAEALAELLNEA------GIRAAVVTGDTPKKEREEILEA 350
AAA_16 pfam13191
AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the ...
 398-550 9.97e-03

AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily.


Pssm-ID: 433025 [Multi-domain]  Cd Length: 167  Bit Score: 38.25  E-value: 9.97e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290    398 DPHRDTILNAIEQH-----PVVVISGDTGCGKTT---RIPQLLLER--YVTEGRGARCNVIITQPRRISAVSVAQRVSHE 467
Cdd:pfam13191    6 EEELEQLLDALDRVrsgrpPSVLLTGEAGTGKTTllrELLRALERDggYFLRGKCDENLPYSPLLEALTREGLLRQLLDE 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336290    468 LGPSLRRNVGFQVRLESKP-PSRGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTdflLILLKGLQRLNPAL 546
Cdd:pfam13191   86 LESSLLEAWRAALLEALAPvPELPGDLAERLLDLLLRLLDLLARGERPLVLVLDDLQWADEAS---LQLLAALLRLLESL 162


                   ....
gi 20336290    547 RLVL 550
Cdd:pfam13191  163 PLLV 166
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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