NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|24308013|ref|NP_055975|]
View 

mitochondrial-processing peptidase subunit alpha isoform 1 precursor [Homo sapiens]

Protein Classification

M16 family metallopeptidase( domain architecture ID 11427472)

M16 family metallopeptidase is a zinc-binding protein that may act as a peptidase cleaving small peptides close to a terminus, often including bonds on the amino side of basic residues such as arginine; similar to Escherichia coli zinc protease PqqL

CATH:  3.30.830.10
Gene Ontology:  GO:0046872|GO:0008237
MEROPS:  M16
PubMed:  1570301
SCOP:  3001831

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
PqqL COG0612
Predicted Zn-dependent peptidase, M16 family [General function prediction only];
62-496 3.11e-62

Predicted Zn-dependent peptidase, M16 family [General function prediction only];


:

Pssm-ID: 440377 [Multi-domain]  Cd Length: 427  Bit Score: 209.78  E-value: 3.11e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308013  62 QEKFETKVTTLDNGLRVA-----SQNKFgqfcTVGILINSGSRYEAKYLSGIAHFLEKLAFSSTARFDSkDEILLTLEKH 136
Cdd:COG0612  10 AAAPDVEEFTLPNGLRVIlvpdpEAPVV----SVRLWVRVGSRDEPPGKTGLAHFLEHMLFKGTKKRSA-GEIAEELEAL 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308013 137 GGICDCQTSRDTTMYAVSADSKGLDTVVALLADVVLQPRLTDEEVEMTRMAVQFELEDLNLrpDPEPLLTEMIHEAAYRE 216
Cdd:COG0612  85 GGSLNAFTSFDYTVYYLSVLSEDLELALELLADRLLNPTFDEEELERERGVVLEEIRRYED--DPDGLAFEALLAALYGD 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308013 217 NTVGLHRFCPTENVAKINREVLHSYLRNYYTPDRMVLAGVG-VEHEHLVDCARKYlLGVQPAwgSAEAVDIDRSVAQYTG 295
Cdd:COG0612 163 HPYGRPIIGTEESIEAITREDLRAFYKRYYRPNNAVLVVVGdVDPEEVLALVEKY-FGDLPA--GPAPPRPDPAEPPQTG 239
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308013 296 GIAKLERDMSNvslgptpipELTHIMVGLESCSFLEEDFIPFAVLNMMMGGggsfsaggpgkGMFSRLYLNVLNRHHWMY 375
Cdd:COG0612 240 PRRVVVDDPDA---------EQAHILLGYPGPARDDPDYYALDVLNEILGG-----------GFSSRLFQELREKKGLAY 299
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308013 376 NATSYHHSYEDTGLLCIHASADPRQVREMVEIITKEF-ILMGGTVDTVELERAKTQLTSMLMMNLESRPVIFEDVGRQVL 454
Cdd:COG0612 300 SVGSSFSPYRDAGLFTIYAGTAPDKLEEALAAILEELeRLAKEGVTEEELERAKNQLLGSLALSLESNSGLASQLGRYEL 379
                       410       420       430       440
                ....*....|....*....|....*....|....*....|...
gi 24308013 455 ATRSRKLPHELCTLIRNVKPEDVKRVASKMLRGKP-AVAALGD 496
Cdd:COG0612 380 YGGDLDYLEEYLERIEAVTAEDVQAVARKYLDPDNlVVVVVGP 422
 
Name Accession Description Interval E-value
PqqL COG0612
Predicted Zn-dependent peptidase, M16 family [General function prediction only];
62-496 3.11e-62

Predicted Zn-dependent peptidase, M16 family [General function prediction only];


Pssm-ID: 440377 [Multi-domain]  Cd Length: 427  Bit Score: 209.78  E-value: 3.11e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308013  62 QEKFETKVTTLDNGLRVA-----SQNKFgqfcTVGILINSGSRYEAKYLSGIAHFLEKLAFSSTARFDSkDEILLTLEKH 136
Cdd:COG0612  10 AAAPDVEEFTLPNGLRVIlvpdpEAPVV----SVRLWVRVGSRDEPPGKTGLAHFLEHMLFKGTKKRSA-GEIAEELEAL 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308013 137 GGICDCQTSRDTTMYAVSADSKGLDTVVALLADVVLQPRLTDEEVEMTRMAVQFELEDLNLrpDPEPLLTEMIHEAAYRE 216
Cdd:COG0612  85 GGSLNAFTSFDYTVYYLSVLSEDLELALELLADRLLNPTFDEEELERERGVVLEEIRRYED--DPDGLAFEALLAALYGD 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308013 217 NTVGLHRFCPTENVAKINREVLHSYLRNYYTPDRMVLAGVG-VEHEHLVDCARKYlLGVQPAwgSAEAVDIDRSVAQYTG 295
Cdd:COG0612 163 HPYGRPIIGTEESIEAITREDLRAFYKRYYRPNNAVLVVVGdVDPEEVLALVEKY-FGDLPA--GPAPPRPDPAEPPQTG 239
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308013 296 GIAKLERDMSNvslgptpipELTHIMVGLESCSFLEEDFIPFAVLNMMMGGggsfsaggpgkGMFSRLYLNVLNRHHWMY 375
Cdd:COG0612 240 PRRVVVDDPDA---------EQAHILLGYPGPARDDPDYYALDVLNEILGG-----------GFSSRLFQELREKKGLAY 299
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308013 376 NATSYHHSYEDTGLLCIHASADPRQVREMVEIITKEF-ILMGGTVDTVELERAKTQLTSMLMMNLESRPVIFEDVGRQVL 454
Cdd:COG0612 300 SVGSSFSPYRDAGLFTIYAGTAPDKLEEALAAILEELeRLAKEGVTEEELERAKNQLLGSLALSLESNSGLASQLGRYEL 379
                       410       420       430       440
                ....*....|....*....|....*....|....*....|...
gi 24308013 455 ATRSRKLPHELCTLIRNVKPEDVKRVASKMLRGKP-AVAALGD 496
Cdd:COG0612 380 YGGDLDYLEEYLERIEAVTAEDVQAVARKYLDPDNlVVVVVGP 422
Peptidase_M16 pfam00675
Insulinase (Peptidase family M16);
77-227 4.93e-52

Insulinase (Peptidase family M16);


Pssm-ID: 425812 [Multi-domain]  Cd Length: 149  Bit Score: 174.03  E-value: 4.93e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308013    77 RVASQNK-FGQFCTVGILINSGSRYEAKYLSGIAHFLEKLAFSSTARFDSkDEILLTLEKHGGICDCQTSRDTTMYAVSA 155
Cdd:pfam00675   1 RVASESDpPADTSTVGLWIDAGSRYEPDNNNGLAHFLEHMAFKGTKKYPS-NELEEELEKLGGSLNAFTSRENTVYYAEV 79
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24308013   156 DSKGLDTVVALLADVVLQPRLTDEEVEMTRMAVQFELEDLNLRpdPEPLLTEMIHEAAYRENTVGLHRFCPT 227
Cdd:pfam00675  80 LNDDLPKAVDRLADFFRNPLFTESEIERERLVVLYEVEAVDSE--PQLVVLENLHAAAYRNTPLGRSLLGPG 149
PRK15101 PRK15101
protease3; Provisional
107-196 4.54e-04

protease3; Provisional


Pssm-ID: 185056 [Multi-domain]  Cd Length: 961  Bit Score: 43.04  E-value: 4.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308013  107 GIAHFLEKLAFSSTARF---DSKDEILltlEKHGGICDCQTSRDTTMYAVSADSKGLDTVVALLADVVLQPRL----TDE 179
Cdd:PRK15101  85 GLAHYLEHMVLMGSKKYpqpDSLAEFL---KKHGGSHNASTASYRTAFYLEVENDALPPAVDRLADAIAEPLLdpknADR 161
                         90       100       110
                 ....*....|....*....|....*....|
gi 24308013  180 EV-----EMT--------RMAvQFELEDLN 196
Cdd:PRK15101 162 ERnavnaELTmarsrdgmRMA-QVSAETIN 190
 
Name Accession Description Interval E-value
PqqL COG0612
Predicted Zn-dependent peptidase, M16 family [General function prediction only];
62-496 3.11e-62

Predicted Zn-dependent peptidase, M16 family [General function prediction only];


Pssm-ID: 440377 [Multi-domain]  Cd Length: 427  Bit Score: 209.78  E-value: 3.11e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308013  62 QEKFETKVTTLDNGLRVA-----SQNKFgqfcTVGILINSGSRYEAKYLSGIAHFLEKLAFSSTARFDSkDEILLTLEKH 136
Cdd:COG0612  10 AAAPDVEEFTLPNGLRVIlvpdpEAPVV----SVRLWVRVGSRDEPPGKTGLAHFLEHMLFKGTKKRSA-GEIAEELEAL 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308013 137 GGICDCQTSRDTTMYAVSADSKGLDTVVALLADVVLQPRLTDEEVEMTRMAVQFELEDLNLrpDPEPLLTEMIHEAAYRE 216
Cdd:COG0612  85 GGSLNAFTSFDYTVYYLSVLSEDLELALELLADRLLNPTFDEEELERERGVVLEEIRRYED--DPDGLAFEALLAALYGD 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308013 217 NTVGLHRFCPTENVAKINREVLHSYLRNYYTPDRMVLAGVG-VEHEHLVDCARKYlLGVQPAwgSAEAVDIDRSVAQYTG 295
Cdd:COG0612 163 HPYGRPIIGTEESIEAITREDLRAFYKRYYRPNNAVLVVVGdVDPEEVLALVEKY-FGDLPA--GPAPPRPDPAEPPQTG 239
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308013 296 GIAKLERDMSNvslgptpipELTHIMVGLESCSFLEEDFIPFAVLNMMMGGggsfsaggpgkGMFSRLYLNVLNRHHWMY 375
Cdd:COG0612 240 PRRVVVDDPDA---------EQAHILLGYPGPARDDPDYYALDVLNEILGG-----------GFSSRLFQELREKKGLAY 299
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308013 376 NATSYHHSYEDTGLLCIHASADPRQVREMVEIITKEF-ILMGGTVDTVELERAKTQLTSMLMMNLESRPVIFEDVGRQVL 454
Cdd:COG0612 300 SVGSSFSPYRDAGLFTIYAGTAPDKLEEALAAILEELeRLAKEGVTEEELERAKNQLLGSLALSLESNSGLASQLGRYEL 379
                       410       420       430       440
                ....*....|....*....|....*....|....*....|...
gi 24308013 455 ATRSRKLPHELCTLIRNVKPEDVKRVASKMLRGKP-AVAALGD 496
Cdd:COG0612 380 YGGDLDYLEEYLERIEAVTAEDVQAVARKYLDPDNlVVVVVGP 422
Peptidase_M16 pfam00675
Insulinase (Peptidase family M16);
77-227 4.93e-52

Insulinase (Peptidase family M16);


Pssm-ID: 425812 [Multi-domain]  Cd Length: 149  Bit Score: 174.03  E-value: 4.93e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308013    77 RVASQNK-FGQFCTVGILINSGSRYEAKYLSGIAHFLEKLAFSSTARFDSkDEILLTLEKHGGICDCQTSRDTTMYAVSA 155
Cdd:pfam00675   1 RVASESDpPADTSTVGLWIDAGSRYEPDNNNGLAHFLEHMAFKGTKKYPS-NELEEELEKLGGSLNAFTSRENTVYYAEV 79
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24308013   156 DSKGLDTVVALLADVVLQPRLTDEEVEMTRMAVQFELEDLNLRpdPEPLLTEMIHEAAYRENTVGLHRFCPT 227
Cdd:pfam00675  80 LNDDLPKAVDRLADFFRNPLFTESEIERERLVVLYEVEAVDSE--PQLVVLENLHAAAYRNTPLGRSLLGPG 149
Peptidase_M16_C pfam05193
Peptidase M16 inactive domain; Peptidase M16 consists of two structurally related domains. One ...
232-431 2.95e-33

Peptidase M16 inactive domain; Peptidase M16 consists of two structurally related domains. One is the active peptidase, whereas the other is inactive. The two domains hold the substrate like a clamp.


Pssm-ID: 428362 [Multi-domain]  Cd Length: 181  Bit Score: 124.81  E-value: 2.95e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308013   232 KINREVLHSYLRNYYTPDRMVLAGVG-VEHEHLVDCARKYLlGVQPAWGSAEAVDIDRSVAQYTGGIAKLERDmsNVslg 310
Cdd:pfam05193   1 SLTREDLRDFYKKHYSPDNMVLVIVGdVDHEELLDLAEKYF-GDLPASPKGKPRPPPLEPAKLKGREVVVPKK--DE--- 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308013   311 ptpipELTHIMVGLESCSFL-EEDFIPFAVLNMMMGGggsfsaggpgkGMFSRLYLNVLNRHHWMYNATSYHHSYEDTGL 389
Cdd:pfam05193  75 -----PQAHLALAFPGPPLNnDEDSLALDVLNELLGG-----------GMSSRLFQELREKEGLAYSVSSFNDSYSDSGL 138
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 24308013   390 LCIHASADPRQVREMVEIITKEFI-LMGGTVDTVELERAKTQL 431
Cdd:pfam05193 139 FGIYATVDPENVDEVIELILEELEkLAQEGVTEEELERAKNQL 181
PRK15101 PRK15101
protease3; Provisional
107-196 4.54e-04

protease3; Provisional


Pssm-ID: 185056 [Multi-domain]  Cd Length: 961  Bit Score: 43.04  E-value: 4.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308013  107 GIAHFLEKLAFSSTARF---DSKDEILltlEKHGGICDCQTSRDTTMYAVSADSKGLDTVVALLADVVLQPRL----TDE 179
Cdd:PRK15101  85 GLAHYLEHMVLMGSKKYpqpDSLAEFL---KKHGGSHNASTASYRTAFYLEVENDALPPAVDRLADAIAEPLLdpknADR 161
                         90       100       110
                 ....*....|....*....|....*....|
gi 24308013  180 EV-----EMT--------RMAvQFELEDLN 196
Cdd:PRK15101 162 ERnavnaELTmarsrdgmRMA-QVSAETIN 190
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH