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Conserved domains on  [gi|154689719|ref|NP_056002|]
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protein sel-1 homolog 3 isoform 1 [Homo sapiens]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11434433)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
679-870 6.30e-37

TPR repeat [General function prediction only];


:

Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 139.68  E-value: 6.30e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154689719  679 WLKHEATRGNAAAQQRLAQMLFWGQqGVAKNPEAAIEWYAKGAlETEDPALIYDYAIVLFKGQGVKKNRRLALELMKKAA 758
Cdd:COG0790    53 AAAAAAAAGGAEAQYNLGLMYAEGR-GVPKDYEKALEWFEKAA-EQGDAEAQYNLGLMYEEGLGVPQDYAKALEWYEKAA 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154689719  759 SKGLHQAVNGLGWYYHK---FKKNYAKAAKYWLKAEEMGNPDASYNLGVLHLDGIfpGVPgRNQTLAGEYFHKAAQGGHM 835
Cdd:COG0790   131 EQGDADAQYNLGLLYLNgegVPKDPAKAAEWYRKAAEQGDADAQYNLGVLYENGR--GVP-KDPAKALEWYRKAAEQGDA 207

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 154689719  836 EGTLWCSLYYITGnlETFPRDPEKAVVWAKHVAEK 870
Cdd:COG0790   208 DAQYNLGRLYLNG--EGVEKDLEKALRWLRKAAEQ 240
 
Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
679-870 6.30e-37

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 139.68  E-value: 6.30e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154689719  679 WLKHEATRGNAAAQQRLAQMLFWGQqGVAKNPEAAIEWYAKGAlETEDPALIYDYAIVLFKGQGVKKNRRLALELMKKAA 758
Cdd:COG0790    53 AAAAAAAAGGAEAQYNLGLMYAEGR-GVPKDYEKALEWFEKAA-EQGDAEAQYNLGLMYEEGLGVPQDYAKALEWYEKAA 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154689719  759 SKGLHQAVNGLGWYYHK---FKKNYAKAAKYWLKAEEMGNPDASYNLGVLHLDGIfpGVPgRNQTLAGEYFHKAAQGGHM 835
Cdd:COG0790   131 EQGDADAQYNLGLLYLNgegVPKDPAKAAEWYRKAAEQGDADAQYNLGVLYENGR--GVP-KDPAKALEWYRKAAEQGDA 207

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 154689719  836 EGTLWCSLYYITGnlETFPRDPEKAVVWAKHVAEK 870
Cdd:COG0790   208 DAQYNLGRLYLNG--EGVEKDLEKALRWLRKAAEQ 240
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 731-761 1.23e-04

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 40.20  E-value: 1.23e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 154689719   731 YDYAIVLFKGQGVKKNRRLALELMKKAASKG 761
Cdd:pfam08238    5 YRLGYLYLYGLGVPKDPEKALEWYEKAAELG 35
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 796-834 9.30e-04

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 37.92  E-value: 9.30e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 154689719    796 PDASYNLGVLHLDGIfpGVPgRNQTLAGEYFHKAAQGGH 834
Cdd:smart00671    1 AEAQYNLGQMYEYGL--GVP-KDLEKALEYYKKAAELGN 36
 
Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
679-870 6.30e-37

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 139.68  E-value: 6.30e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154689719  679 WLKHEATRGNAAAQQRLAQMLFWGQqGVAKNPEAAIEWYAKGAlETEDPALIYDYAIVLFKGQGVKKNRRLALELMKKAA 758
Cdd:COG0790    53 AAAAAAAAGGAEAQYNLGLMYAEGR-GVPKDYEKALEWFEKAA-EQGDAEAQYNLGLMYEEGLGVPQDYAKALEWYEKAA 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154689719  759 SKGLHQAVNGLGWYYHK---FKKNYAKAAKYWLKAEEMGNPDASYNLGVLHLDGIfpGVPgRNQTLAGEYFHKAAQGGHM 835
Cdd:COG0790   131 EQGDADAQYNLGLLYLNgegVPKDPAKAAEWYRKAAEQGDADAQYNLGVLYENGR--GVP-KDPAKALEWYRKAAEQGDA 207

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 154689719  836 EGTLWCSLYYITGnlETFPRDPEKAVVWAKHVAEK 870
Cdd:COG0790   208 DAQYNLGRLYLNG--EGVEKDLEKALRWLRKAAEQ 240
TPR COG0790
TPR repeat [General function prediction only];
677-831 2.47e-31

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 123.50  E-value: 2.47e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154689719  677 FMWLKHEATRGNAAAQQRLAQMLFWGqQGVAKNPEAAIEWYAKGAlETEDPALIYDYAIVLFKGQGVKKNRRLALELMKK 756
Cdd:COG0790    87 LEWFEKAAEQGDAEAQYNLGLMYEEG-LGVPQDYAKALEWYEKAA-EQGDADAQYNLGLLYLNGEGVPKDPAKAAEWYRK 164

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 154689719  757 AASKGLHQAVNGLGWYYHK---FKKNYAKAAKYWLKAEEMGNPDASYNLGVLHLDGIfpGVPgRNQTLAGEYFHKAAQ 831
Cdd:COG0790   165 AAEQGDADAQYNLGVLYENgrgVPKDPAKALEWYRKAAEQGDADAQYNLGRLYLNGE--GVE-KDLEKALRWLRKAAE 239
TPR COG0790
TPR repeat [General function prediction only];
678-902 3.24e-28

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 114.26  E-value: 3.24e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154689719  678 MWLKHEATRGNAAAQQRLAQMLFWGQQGVAKNPEAAIEWYAKGALETEDPALiYDYAIVLFKGQGVKKNRRLALELMKKA 757
Cdd:COG0790    15 AAALAAAAAAAGAAAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQ-YNLGLMYAEGRGVPKDYEKALEWFEKA 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154689719  758 ASKGLHQAVNGLGWYYHK---FKKNYAKAAKYWLKAEEMGNPDASYNLGVLHLDGIfpGVPgRNQTLAGEYFHKAAQGGH 834
Cdd:COG0790    94 AEQGDAEAQYNLGLMYEEglgVPQDYAKALEWYEKAAEQGDADAQYNLGLLYLNGE--GVP-KDPAKAAEWYRKAAEQGD 170

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 154689719  835 MEGTLWCSLYYITGnlETFPRDPEKAVVWAKHVAEKN-----GYLGHVIRKGLnaYLEGSWHEALLYYVLAAE 902
Cdd:COG0790   171 ADAQYNLGVLYENG--RGVPKDPAKALEWYRKAAEQGdadaqYNLGRLYLNGE--GVEKDLEKALRWLRKAAE 239
TPR COG0790
TPR repeat [General function prediction only];
701-927 1.63e-20

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 91.91  E-value: 1.63e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154689719  701 WGQQGVAKNPEAAIEWYAKGALETEDPALIYDYAIVLFKGQGVKKNRRLALELMKKAASKGLHQAVNGLGWYYHK---FK 777
Cdd:COG0790     1 LALAAAAAAAAAAAAAALAAAAAAAGAAAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEgrgVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154689719  778 KNYAKAAKYWLKAEEMGNPDASYNLGVLHLDGIfpGVPgRNQTLAGEYFHKAAQGGHMEGTLWCSLYYITGnlETFPRDP 857
Cdd:COG0790    81 KDYEKALEWFEKAAEQGDAEAQYNLGLMYEEGL--GVP-QDYAKALEWYEKAAEQGDADAQYNLGLLYLNG--EGVPKDP 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154689719  858 EKAVVWAKHVAEkNGY------LGHVIRKGLnaYLEGSWHEALLYYVLAAETGIEVSQTNLAHI------CEERPDLARR 925
Cdd:COG0790   156 AKAAEWYRKAAE-QGDadaqynLGVLYENGR--GVPKDPAKALEWYRKAAEQGDADAQYNLGRLylngegVEKDLEKALR 232


                  ..
gi 154689719  926 YL 927
Cdd:COG0790   233 WL 234
TPR COG0790
TPR repeat [General function prediction only];
748-1001 9.38e-11

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 63.41  E-value: 9.38e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154689719  748 RLALELMKKAASKGLHQAVNGLGWYYHKFKKNYAKAAKYWLKAEEMGNPDASYNLGVLHLDGIfpGVPgRNQTLAGEYFH 827
Cdd:COG0790    15 AAALAAAAAAAGAAAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEGR--GVP-KDYEKALEWFE 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154689719  828 KAAQGGHMEGTLWCSLYYITGnlETFPRDPEKAVVWakhvaekngylghvirkglnaylegswheallyYVLAAETGIEV 907
Cdd:COG0790    92 KAAEQGDAEAQYNLGLMYEEG--LGVPQDYAKALEW---------------------------------YEKAAEQGDAD 136

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154689719  908 SQTNLahiceerpdlarrylgvncvwryynfsvfqidapsfaylkmGDLYYYGHQNQsQDLELSVQMYAQAALDGDSQGF 987
Cdd:COG0790   137 AQYNL-----------------------------------------GLLYLNGEGVP-KDPAKAAEWYRKAAEQGDADAQ 174

                         250
                  ....*....|....
gi 154689719  988 FNLALLIEEGTIIP 1001
Cdd:COG0790   175 YNLGVLYENGRGVP 188
TPR COG0790
TPR repeat [General function prediction only];
568-758 8.42e-09

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 57.63  E-value: 8.42e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154689719  568 GYHKASYYLAVFYETGLNVPRDQLQGmlyslvggqgserlssmnlgykhyqgidnypldwelsyayysniatktpldqht 647
Cdd:COG0790   133 GDADAQYNLGLLYLNGEGVPKDPAKA------------------------------------------------------ 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154689719  648 lqgdqayvetirlkddeilkvqtkedgdvFMWLKHEATRGNAAAQQRLAQMLFWGqQGVAKNPEAAIEWYAKGAlETEDP 727
Cdd:COG0790   159 -----------------------------AEWYRKAAEQGDADAQYNLGVLYENG-RGVPKDPAKALEWYRKAA-EQGDA 207

                         170       180       190
                  ....*....|....*....|....*....|.
gi 154689719  728 ALIYDYAIVLFKGQGVKKNRRLALELMKKAA 758
Cdd:COG0790   208 DAQYNLGRLYLNGEGVEKDLEKALRWLRKAA 238
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 687-798 1.03e-06

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 48.85  E-value: 1.03e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154689719  687 GNAAAQQRLAQMLFWgqqgvAKNPEAAIEWYAKG-ALETEDPALIYDYAIVLFKGQGVKKnrrlALELMKKAASK--GLH 763
Cdd:COG4235    15 NDAEGWLLLGRAYLR-----LGRYDEALAAYEKAlRLDPDNADALLDLAEALLAAGDTEE----AEELLERALALdpDNP 85

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 154689719  764 QAVNGLGWYYHKfKKNYAKAAKYWLKAEEMGNPDA 798
Cdd:COG4235    86 EALYLLGLAAFQ-QGDYAEAIAAWQKLLALLPADA 119
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 731-761 1.23e-04

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 40.20  E-value: 1.23e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 154689719   731 YDYAIVLFKGQGVKKNRRLALELMKKAASKG 761
Cdd:pfam08238    5 YRLGYLYLYGLGVPKDPEKALEWYEKAAELG 35
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 689-721 7.60e-04

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 37.89  E-value: 7.60e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 154689719   689 AAAQQRLAQMLFWGQqGVAKNPEAAIEWYAKGA 721
Cdd:pfam08238    1 AEAQYRLGYLYLYGL-GVPKDPEKALEWYEKAA 32
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 796-834 9.30e-04

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 37.92  E-value: 9.30e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 154689719    796 PDASYNLGVLHLDGIfpGVPgRNQTLAGEYFHKAAQGGH 834
Cdd:smart00671    1 AEAQYNLGQMYEYGL--GVP-KDLEKALEYYKKAAELGN 36
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 796-833 2.31e-03

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 36.73  E-value: 2.31e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 154689719   796 PDASYNLGVLHLDGIfpGVPgRNQTLAGEYFHKAAQGG 833
Cdd:pfam08238    1 AEAQYRLGYLYLYGL--GVP-KDPEKALEWYEKAAELG 35
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 731-761 2.83e-03

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 36.38  E-value: 2.83e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 154689719    731 YDYAIVLFKGQGVKKNRRLALELMKKAASKG 761
Cdd:smart00671    5 YNLGQMYEYGLGVPKDLEKALEYYKKAAELG 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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