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Conserved domains on  [gi|28626517|ref|NP_056383|]
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protein phosphatase 1 regulatory inhibitor subunit 16B isoform 1 precursor [Homo sapiens]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat domain-containing protein; ANK proteins mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

Gene Ontology:  GO:0005515
PubMed:  17176038
SCOP:  4000366

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
71-321 6.99e-37

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 138.55  E-value: 6.99e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517  71 ALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAATCGHINLV 150
Cdd:COG0666  57 LLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIV 136

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517 151 KILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETcmayqgitqekinemrvapeqqmiadihcMIAAGQDLDWIDAQGA 230
Cdd:COG0666 137 KLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKL-----------------------------LLEAGADVNARDNDGE 187

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517 231 TLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPIDLCEEEEFKVL 310
Cdd:COG0666 188 TPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALI 267

                       250
                ....*....|.
gi 28626517 311 LLELKHKHDVI 321
Cdd:COG0666 268 VKLLLLALLLL 278
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
71-321 6.99e-37

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 138.55  E-value: 6.99e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517  71 ALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAATCGHINLV 150
Cdd:COG0666  57 LLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIV 136

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517 151 KILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETcmayqgitqekinemrvapeqqmiadihcMIAAGQDLDWIDAQGA 230
Cdd:COG0666 137 KLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKL-----------------------------LLEAGADVNARDNDGE 187

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517 231 TLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPIDLCEEEEFKVL 310
Cdd:COG0666 188 TPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALI 267

                       250
                ....*....|.
gi 28626517 311 LLELKHKHDVI 321
Cdd:COG0666 268 VKLLLLALLLL 278
Ank_2 pfam12796
Ankyrin repeats (3 copies);
72-164 1.54e-22

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 92.10  E-value: 1.54e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517    72 LLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHgANVNAKDNElWTPLHAAATCGHINLVK 151
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNG-RTALHYAARSGHLEIVK 78

                          90
                  ....*....|...
gi 28626517   152 ILVQYGADLLAVN 164
Cdd:pfam12796  79 LLLEKGADINVKD 91
PHA03095 PHA03095
ankyrin-like protein; Provisional
 71-301 7.80e-18

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 86.23  E-value: 7.80e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517   71 ALLEASLRNDAEEVRYFLKNKV---SPDLCnedGLTALHQC-CIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAAT--C 144
Cdd:PHA03095  53 LYLHYSSEKVKDIVRLLLEAGAdvnAPERC---GFTPLHLYlYNATTLDVIKLLIKAGADVNAKDKVGRTPLHVYLSgfN 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517  145 GHINLVKILVQYGADLLAVNSDGNMPYD--LCEDEPTLDVIETCMAYQGITQEKINEMRVAPEQqmIAD--------IHC 214
Cdd:PHA03095 130 INPKVIRLLLRKGADVNALDLYGMTPLAvlLKSRNANVELLRLLIDAGADVYAVDDRFRSLLHH--HLQsfkprariVRE 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517  215 MIAAGQDLDWIDAQGATLLHIAGANGYLRAAEL--LLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSART 292
Cdd:PHA03095 208 LIRAGCDPAATDMLGNTPLHSMATGSSCKRSLVlpLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVS 287


                 ....*....
gi 28626517  293 SMDEMPIDL 301
Cdd:PHA03095 288 SDGNTPLSL 296
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 67-170 3.47e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 50.01  E-value: 3.47e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517  67 EASVALLEASlrndaeevryflknkvsPDLCNE-------DGLTALHQCCIDNFEEIVKLLLSHGANVNA---------- 129
Cdd:cd22192  65 EAAVVLMEAA-----------------PELVNEpmtsdlyQGETALHIAVVNQNLNLVRELIARGADVVSpratgtffrp 127

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 28626517 130 -KDNELW---TPLHAAATCGHINLVKILVQYGADLLAVNSDGNMP 170
Cdd:cd22192 128 gPKNLIYygeHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTV 172
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 100-129 1.43e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 41.80  E-value: 1.43e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 28626517    100 DGLTALHQCCIDNFEEIVKLLLSHGANVNA 129
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 67-178 7.76e-04

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 42.38  E-value: 7.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517    67 EASVALLEASLRndaEEVRYFLKNkvSPDLCNE-DGLTALHQCCIDNFEEIVKLLLSHGANVNAKDN------------- 132
Cdd:TIGR00870  98 EAILLHLLAAFR---KSGPLELAN--DQYTSEFtPGITALHLAAHRQNYEIVKLLLERGASVPARACgdffvksqgvdsf 172

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 28626517   133 ---ELwtPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEP 178
Cdd:TIGR00870 173 yhgES--PLNAAACLGSPSIVALLSEDPADILTADSLGNTLLHLLVMEN 219
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
71-321 6.99e-37

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 138.55  E-value: 6.99e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517  71 ALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAATCGHINLV 150
Cdd:COG0666  57 LLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIV 136

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517 151 KILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETcmayqgitqekinemrvapeqqmiadihcMIAAGQDLDWIDAQGA 230
Cdd:COG0666 137 KLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKL-----------------------------LLEAGADVNARDNDGE 187

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517 231 TLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPIDLCEEEEFKVL 310
Cdd:COG0666 188 TPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALI 267

                       250
                ....*....|.
gi 28626517 311 LLELKHKHDVI 321
Cdd:COG0666 268 VKLLLLALLLL 278
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
71-315 3.66e-34

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 131.23  E-value: 3.66e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517  71 ALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAATCGHINLV 150
Cdd:COG0666  24 LLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIV 103

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517 151 KILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETcmayqgitqekinemrvapeqqmiadihcMIAAGQDLDWIDAQGA 230
Cdd:COG0666 104 KLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKL-----------------------------LLEAGADVNAQDNDGN 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517 231 TLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPIDLCEEEEFKVL 310
Cdd:COG0666 155 TPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEI 234


                ....*
gi 28626517 311 LLELK 315
Cdd:COG0666 235 VKLLL 239
Ank_2 pfam12796
Ankyrin repeats (3 copies);
72-164 1.54e-22

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 92.10  E-value: 1.54e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517    72 LLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHgANVNAKDNElWTPLHAAATCGHINLVK 151
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNG-RTALHYAARSGHLEIVK 78

                          90
                  ....*....|...
gi 28626517   152 ILVQYGADLLAVN 164
Cdd:pfam12796  79 LLLEKGADINVKD 91
PHA03095 PHA03095
ankyrin-like protein; Provisional
 71-301 7.80e-18

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 86.23  E-value: 7.80e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517   71 ALLEASLRNDAEEVRYFLKNKV---SPDLCnedGLTALHQC-CIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAAT--C 144
Cdd:PHA03095  53 LYLHYSSEKVKDIVRLLLEAGAdvnAPERC---GFTPLHLYlYNATTLDVIKLLIKAGADVNAKDKVGRTPLHVYLSgfN 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517  145 GHINLVKILVQYGADLLAVNSDGNMPYD--LCEDEPTLDVIETCMAYQGITQEKINEMRVAPEQqmIAD--------IHC 214
Cdd:PHA03095 130 INPKVIRLLLRKGADVNALDLYGMTPLAvlLKSRNANVELLRLLIDAGADVYAVDDRFRSLLHH--HLQsfkprariVRE 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517  215 MIAAGQDLDWIDAQGATLLHIAGANGYLRAAEL--LLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSART 292
Cdd:PHA03095 208 LIRAGCDPAATDMLGNTPLHSMATGSSCKRSLVlpLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVS 287


                 ....*....
gi 28626517  293 SMDEMPIDL 301
Cdd:PHA03095 288 SDGNTPLSL 296
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 84-311 6.46e-15

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 77.01  E-value: 6.46e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517   84 VRYFLKNKVSPDLCNEDGLTALHQCCIDNFE-----EIVKLLLSHGANVNAKDNELWTPLHAAATC--GHINLVKILVQY 156
Cdd:PHA03100  51 VKILLDNGADINSSTKNNSTPLHYLSNIKYNltdvkEIVKLLLEYGANVNAPDNNGITPLLYAISKksNSYSIVEYLLDN 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517  157 GADLLAVNSDGNMP--YDLCEDEPTLDVIETcMAYQGItqeKINEM-RVapeqqmiadihcmiaagqdldwidaqgatll 233
Cdd:PHA03100 131 GANVNIKNSDGENLlhLYLESNKIDLKILKL-LIDKGV---DINAKnRV------------------------------- 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517  234 hiagangylraaELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMP----IDLCEEEEFKV 309
Cdd:PHA03100 176 ------------NYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPlhiaILNNNKEIFKL 243


                 ..
gi 28626517  310 LL 311
Cdd:PHA03100 244 LL 245
Ank_2 pfam12796
Ankyrin repeats (3 copies);
105-259 1.44e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 69.37  E-value: 1.44e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517   105 LHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGadllavnsDGNMpydlcedeptldvie 184
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHA--------DVNL--------------- 57

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 28626517   185 tcmayqgitqekinemrvapeqqmiadihcmiaagqdldwiDAQGATLLHIAGANGYLRAAELLLDHGVRVDVKD 259
Cdd:pfam12796  58 -----------------------------------------KDNGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 78-170 4.17e-13

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 71.23  E-value: 4.17e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517   78 RNDAEEVRYFLKNKVSPDLCNEDGLTALHQ----CCIDNfeEIVKLLLSHGANVNAKDN-EL---------------WTP 137
Cdd:PHA03100 118 SNSYSIVEYLLDNGANVNIKNSDGENLLHLylesNKIDL--KILKLLIDKGVDINAKNRvNYllsygvpinikdvygFTP 195

                         90       100       110
                 ....*....|....*....|....*....|...
gi 28626517  138 LHAAATCGHINLVKILVQYGADLLAVNSDGNMP 170
Cdd:PHA03100 196 LHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTP 228
Ank_2 pfam12796
Ankyrin repeats (3 copies);
212-291 1.97e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 63.21  E-value: 1.97e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517   212 IHCMIAAGQDLDWIDAQGATLLHIAGANGYLRAAELLLDHgVRVDVKDwDGWEPLHAAAFWGQMQMAELLVSHGASLSAR 291
Cdd:pfam12796  13 VKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVKLLLEKGADINVK 90
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 20-361 4.97e-12

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 68.74  E-value: 4.97e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517   20 LERLRAAQKRRAQQLKKwaqyeQD--------LQHRKRKH-----ERKRSTGGRRKKVSFEASVaLLEASLRNDA--EEV 84
Cdd:PLN03192 471 LLRLKTSTLIEAMQTRQ-----EDnvvilknfLQHHKELHdlnvgDLLGDNGGEHDDPNMASNL-LTVASTGNAAllEEL 544

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517   85 ryfLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGAdllavn 164
Cdd:PLN03192 545 ---LKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILYHFAS------ 615

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517  165 sdgnmpydlcedeptldvietcmayqgitqekinemrvapeqqmIADIHCmiaagqdldwidaqGATLLHIAGANGYLRA 244
Cdd:PLN03192 616 --------------------------------------------ISDPHA--------------AGDLLCTAAKRNDLTA 637

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517  245 AELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEM-PIDLCEEEEFKvlllELKHKHDV--- 320
Cdd:PLN03192 638 MKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKANTDDDFsPTELRELLQKR----ELGHSITIvds 713

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....
gi 28626517  321 ---IMKSQLRHKSSLSRRTSSAGSRGKVVRRASLSDRTNLYRKE 361
Cdd:PLN03192 714 vpaDEPDLGRDGGSRPGRLQGTSSDNQCRPRVSIYKGHPLLRNE 757
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 70-287 5.51e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 67.71  E-value: 5.51e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517   70 VALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAATCGHINL 149
Cdd:PHA02875   4 VALCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517  150 VKILV---QYGADLLAvnSDGNMPYDLCEDEPTLDVIETCMAYqgitqekinemrvapeqqmiadihcmiaaGQDLDWID 226
Cdd:PHA02875  84 VEELLdlgKFADDVFY--KDGMTPLHLATILKKLDIMKLLIAR-----------------------------GADPDIPN 132

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 28626517  227 AQGATLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGAS 287
Cdd:PHA02875 133 TDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGAN 193
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 109-300 7.79e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 67.30  E-value: 7.79e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517  109 CIDNfeEIVKLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCM- 187
Cdd:PHA02874 101 CIEK--DMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLe 178

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517  188 --AYQGITQEKINE-MRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAGAngYLRAAELLLDHGVRVDVKDWDGWE 264
Cdd:PHA02874 179 kgAYANVKDNNGESpLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAII--HNRSAIELLINNASINDQDIDGST 256

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 28626517  265 PLH-AAAFWGQMQMAELLVSHGASLSARTSMDEMPID 300
Cdd:PHA02874 257 PLHhAINPPCDIDIIDILLYHKADISIKDNKGENPID 293
Ank_4 pfam13637
Ankyrin repeats (many copies);
101-154 8.87e-12

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 59.98  E-value: 8.87e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 28626517   101 GLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILV 154
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 117-189 3.57e-11

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 66.07  E-value: 3.57e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 28626517  117 VKLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMAY 189
Cdd:PTZ00322  98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRH 170
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 116-314 5.94e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 65.08  E-value: 5.94e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517  116 IVKLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMAYQG-ITQ 194
Cdd:PHA02876 160 IAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSnINK 239

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517  195 EKINEMRVAPEQQMIADIhCMIAAGQDLDWIDAQGATLLHIAGANGYL-RAAELLLDHGVRVDVKDWDGWEPLHAAAFWG 273
Cdd:PHA02876 240 NDLSLLKAIRNEDLETSL-LLYDAGFSVNSIDDCKNTPLHHASQAPSLsRLVPKLLERGADVNAKNIKGETPLYLMAKNG 318

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 28626517  274 -QMQMAELLVSHGASLSARTSMDEMPI----DLCEEEEFKVLLLEL 314
Cdd:PHA02876 319 yDTENIRTLIMLGADVNAADRLYITPLhqasTLDRNKDIVITLLEL 364
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 112-323 5.38e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 61.52  E-value: 5.38e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517  112 NFEEIVKLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSdgNMPYdlcedePTLDVIETcMAYQG 191
Cdd:PHA02874  13 DIEAIEKIIKNKGNCINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINT--KIPH------PLLTAIKI-GAHDI 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517  192 ITQEKIN--EMRVAP----EQQMIADIhcmIAAGQDLDWIDAQGATLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEP 265
Cdd:PHA02874  84 IKLLIDNgvDTSILPipciEKDMIKTI---LDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYP 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 28626517  266 LHAAAFWGQMQMAELLVSHGASLSARTSMDEMPI-DLCEEEEFKVLLLELKHKHDVIMK 323
Cdd:PHA02874 161 IHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLhNAAEYGDYACIKLLIDHGNHIMNK 219
Ank_2 pfam12796
Ankyrin repeats (3 copies);
233-284 8.16e-10

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 55.89  E-value: 8.16e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 28626517   233 LHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSH 284
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH 52
PHA02798 PHA02798
ankyrin-like protein; Provisional
 115-267 8.39e-10

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 61.39  E-value: 8.39e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517  115 EIVKLLLSHGANVNAKDNELWTPLHAAATC-----GHINLVKILVQYGADLLAVNSDGNMPydLCedeptldvietCMAY 189
Cdd:PHA02798  52 DIVKLFINLGANVNGLDNEYSTPLCTILSNikdykHMLDIVKILIENGADINKKNSDGETP--LY-----------CLLS 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517  190 QGItqekINEMRVapeqqmiadIHCMIAAGQDLDWIDAQGATLLHI---AGANGYLRAAELLLDHGVRVDV-KDWDGWEP 265
Cdd:PHA02798 119 NGY----INNLEI---------LLFMIENGADTTLLDKDGFTMLQVylqSNHHIDIEIIKLLLEKGVDINThNNKEKYDT 185


                 ..
gi 28626517  266 LH 267
Cdd:PHA02798 186 LH 187
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 82-332 9.54e-10

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 61.05  E-value: 9.54e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517   82 EEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAatCGHIN------LVKILVQ 155
Cdd:PHA02878  18 KYIEYIDHTENYSTSASLIPFIPLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHII--CKEPNklgmkeMIRSINK 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517  156 --YGADLLAVNSDGN---------MPYDLCEDEPTLDVIETC-MAYQGITQEKInemrvapeqqmiadIHCMIAAGQDLD 223
Cdd:PHA02878  96 csVFYTLVAIKDAFNnrnveifkiILTNRYKNIQTIDLVYIDkKSKDDIIEAEI--------------TKLLLSYGADIN 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517  224 WIDA-QGATLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMP--ID 300
Cdd:PHA02878 162 MKDRhKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPlhIS 241

                        250       260       270
                 ....*....|....*....|....*....|..
gi 28626517  301 LCEEEEFKVLLLELKHKHDVIMKSQLRHKSSL 332
Cdd:PHA02878 242 VGYCKDYDILKLLLEHGVDVNAKSYILGLTAL 273
Ank_5 pfam13857
Ankyrin repeats (many copies);
120-174 1.49e-09

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 53.89  E-value: 1.49e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 28626517   120 LLSHG-ANVNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLC 174
Cdd:pfam13857   1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
Ank_4 pfam13637
Ankyrin repeats (many copies);
231-282 2.63e-09

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 53.05  E-value: 2.63e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 28626517   231 TLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLV 282
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 79-159 3.71e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 58.91  E-value: 3.71e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517   79 NDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGA 158
Cdd:PHA03100 170 NAKNRVNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGP 249


                 .
gi 28626517  159 D 159
Cdd:PHA03100 250 S 250
PHA03095 PHA03095
ankyrin-like protein; Provisional
 115-288 7.17e-09

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 58.11  E-value: 7.17e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517  115 EIVKLLLSHGANVNAKDNELWTPLHAAATCGHINLVKI---LVQYGADLLAVNSDGNMPYDLC-EDEPTLDVIETcmayq 190
Cdd:PHA03095  28 EEVRRLLAAGADVNFRGEYGKTPLHLYLHYSSEKVKDIvrlLLEAGADVNAPERCGFTPLHLYlYNATTLDVIKL----- 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517  191 gitqekinemrvapeqqmiadihcMIAAGQDLDWIDAQGATLLHI--AGANGYLRAAELLLDHGVRVDVKDWDGWEPLHA 268
Cdd:PHA03095 103 ------------------------LIKAGADVNAKDKVGRTPLHVylSGFNINPKVIRLLLRKGADVNALDLYGMTPLAV 158

                        170       180
                 ....*....|....*....|
gi 28626517  269 aafwgqmqmaeLLVSHGASL 288
Cdd:PHA03095 159 -----------LLKSRNANV 167
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 78-170 1.04e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 54.58  E-value: 1.04e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517   78 RNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYG 157
Cdd:PHA02874 134 KGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHG 213

                         90
                 ....*....|...
gi 28626517  158 ADLLAVNSDGNMP 170
Cdd:PHA02874 214 NHIMNKCKNGFTP 226
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 71-201 1.74e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 53.52  E-value: 1.74e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517   71 ALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNEL----WTPLHAaatcgh 146
Cdd:PHA03100 195 PLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKTIIETLlyfkDKDLNT------ 268

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 28626517  147 INLVKILVQYGADLLAVNSD--GNMPYdLCEDEPTLDVIETCmayqgitQEKINEMR 201
Cdd:PHA03100 269 ITKIKMLKKSIMYMFLLDPGfyKNRKL-IENSKSLKDVINEC-------EKEIERMK 317
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 80-288 2.62e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 53.53  E-value: 2.62e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517   80 DAEEVRYFLKNKVSPDLCNEDGLTALHQC-CIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGA 158
Cdd:PHA02876 320 DTENIRTLIMLGADVNAADRLYITPLHQAsTLDRNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGA 399

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517  159 DLLAVNSD--GNMPYDLCEDEPTLDVietcmayqgitqekinemrvapeqqmiadiHCMIAAGQDLDWIDAQGATLLHIA 236
Cdd:PHA02876 400 DIEALSQKigTALHFALCGTNPYMSV------------------------------KTLIDRGANVNSKNKDLSTPLHYA 449

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 28626517  237 -GANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAfwGQMQMAELLVSHGASL 288
Cdd:PHA02876 450 cKKNCKLDVIEMLLDNGADVNAINIQNQYPLLIAL--EYHGIVNILLHYGAEL 500
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 84-170 2.70e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 53.35  E-value: 2.70e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517   84 VRYFLKNKVSPDLCNEDGLTALHQC---CIDnfEEIVKLLLSHGANVNAKDNEL-WTPLHAAATCGHInlVKILVQYGAD 159
Cdd:PHA02878 217 VHILLENGASTDARDKCGNTPLHISvgyCKD--YDILKLLLEHGVDVNAKSYILgLTALHSSIKSERK--LKLLLEYGAD 292

                         90
                 ....*....|.
gi 28626517  160 LLAVNSDGNMP 170
Cdd:PHA02878 293 INSLNSYKLTP 303
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 100-132 3.24e-07

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 46.51  E-value: 3.24e-07
                          10        20        30
                  ....*....|....*....|....*....|....
gi 28626517   100 DGLTALHQCCID-NFEEIVKLLLSHGANVNAKDN 132
Cdd:pfam00023   1 DGNTPLHLAAGRrGNLEIVKLLLSKGADVNARDK 34
PHA03095 PHA03095
ankyrin-like protein; Provisional
 147-300 6.46e-07

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 51.95  E-value: 6.46e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517  147 INLVKILVQYGADllaVNSDGnmPYDLCedeptldVIETCMAYQGITQEKInemrvapeqqmiadIHCMIAAGQDLDWID 226
Cdd:PHA03095  27 VEEVRRLLAAGAD---VNFRG--EYGKT-------PLHLYLHYSSEKVKDI--------------VRLLLEAGADVNAPE 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 28626517  227 AQGATLLHIAGANGY-LRAAELLLDHGVRVDVKDWDGWEPLHA--AAFWGQMQMAELLVSHGASLSARTSMDEMPID 300
Cdd:PHA03095  81 RCGFTPLHLYLYNATtLDVIKLLIKAGADVNAKDKVGRTPLHVylSGFNINPKVIRLLLRKGADVNALDLYGMTPLA 157
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 103-299 7.71e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 51.99  E-value: 7.71e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517  103 TALHQCC-IDNFEEIVKLLLSHGANVNAKDNELWTPLHAAATCGH-INLVKILVQYGADLLAVNSDGNMPYdlcEDEPTL 180
Cdd:PHA02876 275 TPLHHASqAPSLSRLVPKLLERGADVNAKNIKGETPLYLMAKNGYdTENIRTLIMLGADVNAADRLYITPL---HQASTL 351

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517  181 D-----VIETCMAYQGITQEKINE---MRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIA--GANGYLrAAELLLD 250
Cdd:PHA02876 352 DrnkdiVITLLELGANVNARDYCDktpIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFAlcGTNPYM-SVKTLID 430

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 28626517  251 HGVRVDVKDWDGWEPLHAAAFWG-QMQMAELLVSHGASLSARTSMDEMPI 299
Cdd:PHA02876 431 RGANVNSKNKDLSTPLHYACKKNcKLDVIEMLLDNGADVNAINIQNQYPL 480
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 212-297 1.48e-06

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 51.05  E-value: 1.48e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517  212 IHCMIAAGQDLDWIDAQGATLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGA---SL 288
Cdd:PTZ00322  98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQchfEL 177


                 ....*....
gi 28626517  289 SARTSMDEM 297
Cdd:PTZ00322 178 GANAKPDSF 186
Ank_4 pfam13637
Ankyrin repeats (many copies);
71-121 3.43e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 44.19  E-value: 3.43e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 28626517    71 ALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLL 121
Cdd:pfam13637   4 ALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 67-170 3.47e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 50.01  E-value: 3.47e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517  67 EASVALLEASlrndaeevryflknkvsPDLCNE-------DGLTALHQCCIDNFEEIVKLLLSHGANVNA---------- 129
Cdd:cd22192  65 EAAVVLMEAA-----------------PELVNEpmtsdlyQGETALHIAVVNQNLNLVRELIARGADVVSpratgtffrp 127

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 28626517 130 -KDNELW---TPLHAAATCGHINLVKILVQYGADLLAVNSDGNMP 170
Cdd:cd22192 128 gPKNLIYygeHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTV 172
PHA02946 PHA02946
ankyin-like protein; Provisional
 80-235 3.52e-06

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 49.67  E-value: 3.52e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517   80 DAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAATCGH--INLVKILVQYG 157
Cdd:PHA02946  51 DERFVEELLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLYYLSGTDDevIERINLLVQYG 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517  158 ADL-LAVNSDGNMPYDLCEDePTLDVIETCMA--YQGITQEKINEMRVapEQQMIAD------IHCMIAAGQDLDWIDAQ 228
Cdd:PHA02946 131 AKInNSVDEEGCGPLLACTD-PSERVFKKIMSigFEARIVDKFGKNHI--HRHLMSDnpkastISWMMKLGISPSKPDHD 207


                 ....*..
gi 28626517  229 GATLLHI 235
Cdd:PHA02946 208 GNTPLHI 214
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 75-212 4.91e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 49.22  E-value: 4.91e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517   75 ASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILV 154
Cdd:PHA02875 109 ATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLL 188

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 28626517  155 QYGADLLAVNSDGN---MPYDLCEDEPTL-----------DVIETCMAYQGITQEKINEMRVAPEQQ----MIADI 212
Cdd:PHA02875 189 DSGANIDYFGKNGCvaaLCYAIENNKIDIvrlfikrgadcNIMFMIEGEECTILDMICNMCTNLESEaidaLIADI 264
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 80-170 7.69e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 48.72  E-value: 7.69e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517   80 DAEEVRYFLKNKVSPDLCNEDGL-TALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGA 158
Cdd:PHA02878 146 EAEITKLLLSYGADINMKDRHKGnTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGA 225

                         90
                 ....*....|..
gi 28626517  159 DLLAVNSDGNMP 170
Cdd:PHA02878 226 STDARDKCGNTP 237
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 135-164 1.06e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 42.28  E-value: 1.06e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 28626517   135 WTPLHAAAT-CGHINLVKILVQYGADLLAVN 164
Cdd:pfam00023   3 NTPLHLAAGrRGNLEIVKLLLSKGADVNARD 33
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 100-129 1.43e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 41.80  E-value: 1.43e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 28626517    100 DGLTALHQCCIDNFEEIVKLLLSHGANVNA 129
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 135-160 2.70e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 41.03  E-value: 2.70e-05
                           10        20
                   ....*....|....*....|....*.
gi 28626517    135 WTPLHAAATCGHINLVKILVQYGADL 160
Cdd:smart00248   3 RTPLHLAAENGNLEVVKLLLDKGADI 28
PHA02716 PHA02716
CPXV016; CPX019; EVM010; Provisional
 80-170 2.86e-05

CPXV016; CPX019; EVM010; Provisional


Pssm-ID: 165089 [Multi-domain]  Cd Length: 764  Bit Score: 47.21  E-value: 2.86e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517   80 DAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNF--EEIVKLLLSHGANVNAKDNELWTPLHA------------AATCG 145
Cdd:PHA02716 296 DISVVYSFLQPGVKLHYKDSAGRTCLHQYILRHNisTDIIKLLHEYGNDLNEPDNIGNTVLHTylsmlsvvnildPETDN 375

                         90       100
                 ....*....|....*....|....*..
gi 28626517  146 HINL--VKILVQYGADLLAVNSDGNMP 170
Cdd:PHA02716 376 DIRLdvIQCLISLGADITAVNCLGYTP 402
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 69-160 3.08e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 46.80  E-value: 3.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517   69 SVALLEASLRNDAEEVRYFL---KNKVSPDLCNEdglTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLH-AAATC 144
Cdd:PHA02878 169 NTALHYATENKDQRLTELLLsygANVNIPDKTNN---SPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHiSVGYC 245

                         90
                 ....*....|....*.
gi 28626517  145 GHINLVKILVQYGADL 160
Cdd:PHA02878 246 KDYDILKLLLEHGVDV 261
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 232-316 3.33e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 46.82  E-value: 3.33e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517  232 LLHIAgANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPIDLCEEEEFK-VL 310
Cdd:PTZ00322  86 LCQLA-ASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFReVV 164


                 ....*.
gi 28626517  311 LLELKH 316
Cdd:PTZ00322 165 QLLSRH 170
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 100-129 3.53e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 40.70  E-value: 3.53e-05
                          10        20        30
                  ....*....|....*....|....*....|
gi 28626517   100 DGLTALHQCCIDNFEEIVKLLLSHGANVNA 129
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADINA 30
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 37-283 3.72e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 46.54  E-value: 3.72e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517  37 WAQY--EQDLQHRKRKHErkrstggrrkkvsfeasVALLEASLRNDAEEVRYFLKNKvSPDLCNEDGL--TALHQCCIDN 112
Cdd:cd22192   1 WAQMldELHLLQQKRISE-----------------SPLLLAAKENDVQAIKKLLKCP-SCDLFQRGALgeTALHVAALYD 62

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517 113 FEEIVKLLLSHGAN-VN-AKDNELW---TPLHAAATCGHINLVKILVQYGADLLAVNSDGNM----PYDLCE-DEPTLdV 182
Cdd:cd22192  63 NLEAAVVLMEAAPElVNePMTSDLYqgeTALHIAVVNQNLNLVRELIARGADVVSPRATGTFfrpgPKNLIYyGEHPL-S 141

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517 183 IETCMAYQGITQekinemrvapeqqmiadihCMIAAGQDLDWIDAQGATLLHI----AGANGYLRAAELLL-----DHGV 253
Cdd:cd22192 142 FAACVGNEEIVR-------------------LLIEHGADIRAQDSLGNTVLHIlvlqPNKTFACQMYDLILsydkeDDLQ 202

                       250       260       270
                ....*....|....*....|....*....|.
gi 28626517 254 RVD-VKDWDGWEPLHAAAFWGQMQMAELLVS 283
Cdd:cd22192 203 PLDlVPNNQGLTPFKLAAKEGNIVMFQHLVQ 233
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 75-170 4.26e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 46.60  E-value: 4.26e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517   75 ASLRNDAEEVRYFLKNKVSPDLCNEDGLTALH-QCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAA--TCgHINLVK 151
Cdd:PHA02876 382 AAVRNNVVIINTLLDYGADIEALSQKIGTALHfALCGTNPYMSVKTLIDRGANVNSKNKDLSTPLHYACkkNC-KLDVIE 460

                         90
                 ....*....|....*....
gi 28626517  152 ILVQYGADLLAVNSDGNMP 170
Cdd:PHA02876 461 MLLDNGADVNAINIQNQYP 479
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 242-397 1.66e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 44.67  E-value: 1.66e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517  242 LRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSA---------------------------RTSM 294
Cdd:PHA02876 158 LLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIialddlsvlecavdsknidtikaiidnRSNI 237

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517  295 DEMPIDLC-----EEEEFKVLLLELK---HKHDVIMKSQLRHKS---SLSRRTSSAGSRGKVVRRASLSDRTNLY---RK 360
Cdd:PHA02876 238 NKNDLSLLkairnEDLETSLLLYDAGfsvNSIDDCKNTPLHHASqapSLSRLVPKLLERGADVNAKNIKGETPLYlmaKN 317

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 28626517  361 EYEGEAI--LWQRSAAEDQRTSTYNGDIRETRTDQENKD 397
Cdd:PHA02876 318 GYDTENIrtLIMLGADVNAADRLYITPLHQASTLDRNKD 356
Ank_4 pfam13637
Ankyrin repeats (many copies);
135-170 1.84e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.57  E-value: 1.84e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 28626517   135 WTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMP 170
Cdd:pfam13637   2 LTALHAAAASGHLELLRLLLEKGADINAVDGNGETA 37
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 135-162 2.00e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 38.78  E-value: 2.00e-04
                          10        20
                  ....*....|....*....|....*...
gi 28626517   135 WTPLHAAATCGHINLVKILVQYGADLLA 162
Cdd:pfam13606   3 NTPLHLAARNGRLEIVKLLLENGADINA 30
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 75-290 3.82e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 43.51  E-value: 3.82e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517   75 ASLRNDAEEVRYFLKNKVSPDLCNEDGLTALhQCCID-NFEEIVKLLLSHGANVNAKDNELW------------------ 135
Cdd:PHA02876 185 AAERGNAKMVNLLLSYGADVNIIALDDLSVL-ECAVDsKNIDTIKAIIDNRSNINKNDLSLLkairnedletslllydag 263

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517  136 -----------TPLHAAATCGHIN-LVKILVQYGADLLAVNSDGNMPYDLcedeptldvietcMAYQGITQEkinemrva 203
Cdd:PHA02876 264 fsvnsiddcknTPLHHASQAPSLSrLVPKLLERGADVNAKNIKGETPLYL-------------MAKNGYDTE-------- 322

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517  204 peqqmiaDIHCMIAAGQDLDWIDAQGATLLHIAGA-NGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLV 282
Cdd:PHA02876 323 -------NIRTLIMLGADVNAADRLYITPLHQASTlDRNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLL 395


                 ....*...
gi 28626517  283 SHGASLSA 290
Cdd:PHA02876 396 DYGADIEA 403
PHA02859 PHA02859
ankyrin repeat protein; Provisional
 78-171 4.87e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165195 [Multi-domain]  Cd Length: 209  Bit Score: 41.73  E-value: 4.87e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517   78 RNDAEEVRYFLKnkvSPDLCNEDGLTALHQCCIDNF--EEIVKLLLSHGANVNAK--DNELwTPLHAAATCG---HINLV 150
Cdd:PHA02859  31 KDDIEGVKKWIK---FVNDCNDLYETPIFSCLEKDKvnVEILKFLIENGADVNFKtrDNNL-SALHHYLSFNknvEPEIL 106

                         90       100
                 ....*....|....*....|.
gi 28626517  151 KILVQYGADLLAVNSDGNMPY 171
Cdd:PHA02859 107 KILIDSGSSITEEDEDGKNLL 127
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 261-292 6.08e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 37.27  E-value: 6.08e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 28626517   261 DGWEPLHAAA-FWGQMQMAELLVSHGASLSART 292
Cdd:pfam00023   1 DGNTPLHLAAgRRGNLEIVKLLLSKGADVNARD 33
Ank_5 pfam13857
Ankyrin repeats (many copies);
92-141 6.73e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 38.10  E-value: 6.73e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 28626517    92 VSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAA 141
Cdd:pfam13857   7 IDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 67-178 7.76e-04

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 42.38  E-value: 7.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517    67 EASVALLEASLRndaEEVRYFLKNkvSPDLCNE-DGLTALHQCCIDNFEEIVKLLLSHGANVNAKDN------------- 132
Cdd:TIGR00870  98 EAILLHLLAAFR---KSGPLELAN--DQYTSEFtPGITALHLAAHRQNYEIVKLLLERGASVPARACgdffvksqgvdsf 172

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 28626517   133 ---ELwtPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEP 178
Cdd:TIGR00870 173 yhgES--PLNAAACLGSPSIVALLSEDPADILTADSLGNTLLHLLVMEN 219
Ank_5 pfam13857
Ankyrin repeats (many copies);
215-269 1.29e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 36.94  E-value: 1.29e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 28626517   215 MIAAGQ-DLDWIDAQGATLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAA 269
Cdd:pfam13857   1 LLEHGPiDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA02884 PHA02884
ankyrin repeat protein; Provisional
 117-173 2.18e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165212 [Multi-domain]  Cd Length: 300  Bit Score: 40.35  E-value: 2.18e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 28626517  117 VKLLLSHGANVNAKDNEL-WTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDL 173
Cdd:PHA02884  86 AKLLIRYGADVNRYAEEAkITPLYISVLHGCLKCLEILLSYGADINIQTNDMVTPIEL 143
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 228-259 3.05e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 35.34  E-value: 3.05e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 28626517   228 QGATLLHIA-GANGYLRAAELLLDHGVRVDVKD 259
Cdd:pfam00023   1 DGNTPLHLAaGRRGNLEIVKLLLSKGADVNARD 33
PHA02859 PHA02859
ankyrin repeat protein; Provisional
 114-206 3.10e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165195 [Multi-domain]  Cd Length: 209  Bit Score: 39.42  E-value: 3.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517  114 EEIVKLLLSHGANVNAKDNELWTPLHAAAT-CG-HINLVKILVQYGADLLAVNSDGN---MPYDLCEDEptlDVIETCMA 188
Cdd:PHA02859 103 PEILKILIDSGSSITEEDEDGKNLLHMYMCnFNvRINVIKLLIDSGVSFLNKDFDNNnilYSYILFHSD---KKIFDFLT 179

                         90
                 ....*....|....*...
gi 28626517  189 YQGITQEKINEMRVAPEQ 206
Cdd:PHA02859 180 SLGIDINETNKSGYNCYD 197
PHA03095 PHA03095
ankyrin-like protein; Provisional
 216-320 3.52e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 40.01  E-value: 3.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28626517  216 IAAGQDLDWIDAQGATLLHIAGANG---YLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQ-MQMAELLVSHGASLSAR 291
Cdd:PHA03095  34 LAAGADVNFRGEYGKTPLHLYLHYSsekVKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATtLDVIKLLIKAGADVNAK 113

                         90       100       110
                 ....*....|....*....|....*....|..
gi 28626517  292 TSMDEMPIDLC---EEEEFKVLLLELKHKHDV 320
Cdd:PHA03095 114 DKVGRTPLHVYlsgFNINPKVIRLLLRKGADV 145
Ank_5 pfam13857
Ankyrin repeats (many copies);
75-106 4.78e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 35.40  E-value: 4.78e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 28626517    75 ASLRNDAEEVRYFLKNKVSPDLCNEDGLTALH 106
Cdd:pfam13857  23 AAKYGALEIVRVLLAYGVDLNLKDEEGLTALD 54
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 261-290 4.78e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.87  E-value: 4.78e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 28626517    261 DGWEPLHAAAFWGQMQMAELLVSHGASLSA 290
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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