NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|158534077|ref|NP_056483|]
View 

regulator of G-protein signaling 22 isoform 1 [Homo sapiens]

Protein Classification

RGS_RGS22_3 and RGS_RGS22_4 domain-containing protein( domain architecture ID 10171655)

protein containing domains RGS_RGS22_2, RGS_RGS22_3, and RGS_RGS22_4

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
RGS_RGS22_3 cd08726
Regulator of G protein signaling domain RGS_RGS22_3; The RGS (Regulator of G-protein Signaling) ...
 853-982 1.88e-73

Regulator of G protein signaling domain RGS_RGS22_3; The RGS (Regulator of G-protein Signaling) domain found in the RGS22 protein, a member of the RA/RGS subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. RGS22 contains at least 3 copies of the RGS domain in vertebrata and exists in multiple splicing variants. RGS22 is predominantly expressed in testis and believed to play an important role in spermatogenesis.


:

Pssm-ID: 188681  Cd Length: 130  Bit Score: 239.69  E-value: 1.88e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158534077  853 FSDLLNNKLEFEHFRQFLETHSSSMDLMCWTDIEQFRRITYRDRNQRKAKSIYIKNKYLNKKYFFGPNSPASLYQQNQVM 932
Cdd:cd08726     1 FQDLLHNRLELEFFRKFLEENSASMDLLCWLDIEQFRRIPHTDNAKRDEKAKEIKNKYLNKKYFFGPNSPATKEQQNKVM 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 158534077  933 HLSGGWGKILHEQLDAPVLVEIQKHVQNRLENVWLPLFLASEQFAARQKI 982
Cdd:cd08726    81 HAGGGWGKILHDRPPSSVLIEIQKIVRARLEKHWLPLFLATEQFRRRQAQ 130
RGS_RGS22_4 cd08725
Regulator of G protein signaling domain RGS_RGS22_4; The RGS (Regulator of G-protein Signaling) ...
 1026-1148 3.76e-73

Regulator of G protein signaling domain RGS_RGS22_4; The RGS (Regulator of G-protein Signaling) domain found in the RGS22 protein, a member of the RA/RGS subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. RGS22 contains at least 3 copies of the RGS domain in vertebrata and exists in multiple splicing variants. RGS22 is predominantly expressed in testis and believed to play an important role in spermatogenesis.


:

Pssm-ID: 188680  Cd Length: 123  Bit Score: 238.83  E-value: 3.76e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158534077 1026 LLNPVTSRQFQRFVALKGDLLENGLLFWQEVQKYKDLCHSHCDESVIQKKITTIINCFINSSIPPALQIDIPVEQAQKII 1105
Cdd:cd08725     1 LLNPVTSEQFQRFVSLKGEELENDLLFWLEVQKYKDLCHSHSDEHIIQNKITAIISCFIDSSVPPALQIDIPPEIANRIL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 158534077 1106 EHRKELGPYVFREAQMTIFGVLFKFWPQFCEFRKNLTDENIMS 1148
Cdd:cd08725    81 EHRRELGPYIFREAQLTVFRVLFKYWAGFCEFRKNLQPEKILT 123
RGS_RGS22_2 cd08727
Regulator of G protein signaling domain RGS_RGS22_2; The RGS (Regulator of G-protein Signaling) ...
 670-785 1.16e-58

Regulator of G protein signaling domain RGS_RGS22_2; The RGS (Regulator of G-protein Signaling) domain found in the RGS22 protein, a member of the RA/RGS subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. RGS22 contains at least 3 copies of the RGS domain in vertebrata and exists in multiple splicing variants. RGS22 is predominantly expressed in testis and believed to play an important role in spermatogenesis.


:

Pssm-ID: 188682  Cd Length: 116  Bit Score: 197.27  E-value: 1.16e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158534077  670 VENRAGFFFTKFCEHSGNKLWKNSVYFWFDLQAYHQLFYQETLQPFKVCKQAQYLFATYVAPSATLDIGLQQEKKKEIYM 749
Cdd:cd08727     1 LENRAGNFFTQFCEKSGNKLWKNAVYFWFDLQEYHQLFYTETFQPFKVCRKAQRLFSTYIVPGARHNIGCSVRKRKEIIK 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 158534077  750 KIQPPFEDLFDTAEEYILLLLLEPWTKMVKSDQIAY 785
Cdd:cd08727    81 KLSPPFEDLFDAAEEHILLLLLEPWSKMVKQDEAEY 116
 
Name Accession Description Interval E-value
RGS_RGS22_3 cd08726
Regulator of G protein signaling domain RGS_RGS22_3; The RGS (Regulator of G-protein Signaling) ...
 853-982 1.88e-73

Regulator of G protein signaling domain RGS_RGS22_3; The RGS (Regulator of G-protein Signaling) domain found in the RGS22 protein, a member of the RA/RGS subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. RGS22 contains at least 3 copies of the RGS domain in vertebrata and exists in multiple splicing variants. RGS22 is predominantly expressed in testis and believed to play an important role in spermatogenesis.


Pssm-ID: 188681  Cd Length: 130  Bit Score: 239.69  E-value: 1.88e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158534077  853 FSDLLNNKLEFEHFRQFLETHSSSMDLMCWTDIEQFRRITYRDRNQRKAKSIYIKNKYLNKKYFFGPNSPASLYQQNQVM 932
Cdd:cd08726     1 FQDLLHNRLELEFFRKFLEENSASMDLLCWLDIEQFRRIPHTDNAKRDEKAKEIKNKYLNKKYFFGPNSPATKEQQNKVM 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 158534077  933 HLSGGWGKILHEQLDAPVLVEIQKHVQNRLENVWLPLFLASEQFAARQKI 982
Cdd:cd08726    81 HAGGGWGKILHDRPPSSVLIEIQKIVRARLEKHWLPLFLATEQFRRRQAQ 130
RGS_RGS22_4 cd08725
Regulator of G protein signaling domain RGS_RGS22_4; The RGS (Regulator of G-protein Signaling) ...
 1026-1148 3.76e-73

Regulator of G protein signaling domain RGS_RGS22_4; The RGS (Regulator of G-protein Signaling) domain found in the RGS22 protein, a member of the RA/RGS subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. RGS22 contains at least 3 copies of the RGS domain in vertebrata and exists in multiple splicing variants. RGS22 is predominantly expressed in testis and believed to play an important role in spermatogenesis.


Pssm-ID: 188680  Cd Length: 123  Bit Score: 238.83  E-value: 3.76e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158534077 1026 LLNPVTSRQFQRFVALKGDLLENGLLFWQEVQKYKDLCHSHCDESVIQKKITTIINCFINSSIPPALQIDIPVEQAQKII 1105
Cdd:cd08725     1 LLNPVTSEQFQRFVSLKGEELENDLLFWLEVQKYKDLCHSHSDEHIIQNKITAIISCFIDSSVPPALQIDIPPEIANRIL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 158534077 1106 EHRKELGPYVFREAQMTIFGVLFKFWPQFCEFRKNLTDENIMS 1148
Cdd:cd08725    81 EHRRELGPYIFREAQLTVFRVLFKYWAGFCEFRKNLQPEKILT 123
RGS_RGS22_2 cd08727
Regulator of G protein signaling domain RGS_RGS22_2; The RGS (Regulator of G-protein Signaling) ...
 670-785 1.16e-58

Regulator of G protein signaling domain RGS_RGS22_2; The RGS (Regulator of G-protein Signaling) domain found in the RGS22 protein, a member of the RA/RGS subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. RGS22 contains at least 3 copies of the RGS domain in vertebrata and exists in multiple splicing variants. RGS22 is predominantly expressed in testis and believed to play an important role in spermatogenesis.


Pssm-ID: 188682  Cd Length: 116  Bit Score: 197.27  E-value: 1.16e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158534077  670 VENRAGFFFTKFCEHSGNKLWKNSVYFWFDLQAYHQLFYQETLQPFKVCKQAQYLFATYVAPSATLDIGLQQEKKKEIYM 749
Cdd:cd08727     1 LENRAGNFFTQFCEKSGNKLWKNAVYFWFDLQEYHQLFYTETFQPFKVCRKAQRLFSTYIVPGARHNIGCSVRKRKEIIK 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 158534077  750 KIQPPFEDLFDTAEEYILLLLLEPWTKMVKSDQIAY 785
Cdd:cd08727    81 KLSPPFEDLFDAAEEHILLLLLEPWSKMVKQDEAEY 116
RGS smart00315
Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins ...
 1022-1136 1.23e-12

Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 214613  Cd Length: 118  Bit Score: 65.75  E-value: 1.23e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158534077   1022 FRKALLNPVTSRQFQRFvaLKGDLLENGLLFWQEVQKYKDLchshCDESVIQKKITTIINCFINSSIPPALQIDI-PVEQ 1100
Cdd:smart00315    2 LESLLSDPIGRLLFREF--LESEFSEENLEFWLAVEEFKKA----EDDEERIAKAREIYDKFLSPNAPKEVNLDSdLREK 75

                            90       100       110
                    ....*....|....*....|....*....|....*..
gi 158534077   1101 AQKIIEHRkELGPYVFREAQMTIFGVL-FKFWPQFCE 1136
Cdd:smart00315   76 IEENLESE-EPPPDLFDEAQREVYELLeKDSFPRFLE 111
RGS pfam00615
Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for ...
 852-976 1.71e-07

Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 459870  Cd Length: 117  Bit Score: 51.08  E-value: 1.71e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158534077   852 KFSDLLNNKLEFEHFRQFLETHSSSMDLMCWTDIEQFRRITYRDRNQRKAKSIYikNKYLNkkyffgPNSPASLYQQNQV 931
Cdd:pfam00615    1 SFDSLLEDQPGRRLFRQFLESEFSEENLEFWLACEEFKKADPDEERLKKAKEIY--NEFLA------PGSPKEINLDSDL 72

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 158534077   932 M-HLSGGwgkiLHEQLDAPVLVEIQKHVQNRLENVWLPLFLASEQF 976
Cdd:pfam00615   73 ReEIREN----LEKEPTRDLFDEAQAEVYELMEKDSYPRFLKSPLY 114
RGS smart00315
Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins ...
 852-976 5.31e-06

Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 214613  Cd Length: 118  Bit Score: 46.88  E-value: 5.31e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158534077    852 KFSDLLNNKLEFEHFRQFLETHSSSMDLMCWTDIEQFRRITYRDRNQRKAKSIYIKnkylnkkyFFGPNSPASLYQQNQV 931
Cdd:smart00315    1 SLESLLSDPIGRLLFREFLESEFSEENLEFWLAVEEFKKAEDDEERIAKAREIYDK--------FLSPNAPKEVNLDSDL 72

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*.
gi 158534077    932 M-HLSGGwgkILHEQLDAPVLVEIQKHVQNRLENVWLPLFLASEQF 976
Cdd:smart00315   73 ReKIEEN---LESEEPPPDLFDEAQREVYELLEKDSFPRFLESDYY 115
RGS pfam00615
Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for ...
 1022-1124 3.43e-04

Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 459870  Cd Length: 117  Bit Score: 41.45  E-value: 3.43e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158534077  1022 FRKALLNPVTSRQFQRFvaLKGDLLENGLLFWQEVQKYKdlchSHCDESVIQKKITTIINCFINSSIPPALQIDipvEQA 1101
Cdd:pfam00615    2 FDSLLEDQPGRRLFRQF--LESEFSEENLEFWLACEEFK----KADPDEERLKKAKEIYNEFLAPGSPKEINLD---SDL 72

                           90       100
                   ....*....|....*....|....*
gi 158534077  1102 QKIIEHR--KELGPYVFREAQMTIF 1124
Cdd:pfam00615   73 REEIRENleKEPTRDLFDEAQAEVY 97
 
Name Accession Description Interval E-value
RGS_RGS22_3 cd08726
Regulator of G protein signaling domain RGS_RGS22_3; The RGS (Regulator of G-protein Signaling) ...
 853-982 1.88e-73

Regulator of G protein signaling domain RGS_RGS22_3; The RGS (Regulator of G-protein Signaling) domain found in the RGS22 protein, a member of the RA/RGS subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. RGS22 contains at least 3 copies of the RGS domain in vertebrata and exists in multiple splicing variants. RGS22 is predominantly expressed in testis and believed to play an important role in spermatogenesis.


Pssm-ID: 188681  Cd Length: 130  Bit Score: 239.69  E-value: 1.88e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158534077  853 FSDLLNNKLEFEHFRQFLETHSSSMDLMCWTDIEQFRRITYRDRNQRKAKSIYIKNKYLNKKYFFGPNSPASLYQQNQVM 932
Cdd:cd08726     1 FQDLLHNRLELEFFRKFLEENSASMDLLCWLDIEQFRRIPHTDNAKRDEKAKEIKNKYLNKKYFFGPNSPATKEQQNKVM 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 158534077  933 HLSGGWGKILHEQLDAPVLVEIQKHVQNRLENVWLPLFLASEQFAARQKI 982
Cdd:cd08726    81 HAGGGWGKILHDRPPSSVLIEIQKIVRARLEKHWLPLFLATEQFRRRQAQ 130
RGS_RGS22_4 cd08725
Regulator of G protein signaling domain RGS_RGS22_4; The RGS (Regulator of G-protein Signaling) ...
 1026-1148 3.76e-73

Regulator of G protein signaling domain RGS_RGS22_4; The RGS (Regulator of G-protein Signaling) domain found in the RGS22 protein, a member of the RA/RGS subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. RGS22 contains at least 3 copies of the RGS domain in vertebrata and exists in multiple splicing variants. RGS22 is predominantly expressed in testis and believed to play an important role in spermatogenesis.


Pssm-ID: 188680  Cd Length: 123  Bit Score: 238.83  E-value: 3.76e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158534077 1026 LLNPVTSRQFQRFVALKGDLLENGLLFWQEVQKYKDLCHSHCDESVIQKKITTIINCFINSSIPPALQIDIPVEQAQKII 1105
Cdd:cd08725     1 LLNPVTSEQFQRFVSLKGEELENDLLFWLEVQKYKDLCHSHSDEHIIQNKITAIISCFIDSSVPPALQIDIPPEIANRIL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 158534077 1106 EHRKELGPYVFREAQMTIFGVLFKFWPQFCEFRKNLTDENIMS 1148
Cdd:cd08725    81 EHRRELGPYIFREAQLTVFRVLFKYWAGFCEFRKNLQPEKILT 123
RGS_RGS22_2 cd08727
Regulator of G protein signaling domain RGS_RGS22_2; The RGS (Regulator of G-protein Signaling) ...
 670-785 1.16e-58

Regulator of G protein signaling domain RGS_RGS22_2; The RGS (Regulator of G-protein Signaling) domain found in the RGS22 protein, a member of the RA/RGS subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. RGS22 contains at least 3 copies of the RGS domain in vertebrata and exists in multiple splicing variants. RGS22 is predominantly expressed in testis and believed to play an important role in spermatogenesis.


Pssm-ID: 188682  Cd Length: 116  Bit Score: 197.27  E-value: 1.16e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158534077  670 VENRAGFFFTKFCEHSGNKLWKNSVYFWFDLQAYHQLFYQETLQPFKVCKQAQYLFATYVAPSATLDIGLQQEKKKEIYM 749
Cdd:cd08727     1 LENRAGNFFTQFCEKSGNKLWKNAVYFWFDLQEYHQLFYTETFQPFKVCRKAQRLFSTYIVPGARHNIGCSVRKRKEIIK 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 158534077  750 KIQPPFEDLFDTAEEYILLLLLEPWTKMVKSDQIAY 785
Cdd:cd08727    81 KLSPPFEDLFDAAEEHILLLLLEPWSKMVKQDEAEY 116
RGS cd07440
Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part ...
 857-976 9.54e-19

Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. While inactive, G-alpha-subunits bind GDP, which is released and replaced by GTP upon agonist activation. GTP binding leads to dissociation of the alpha-subunit and the beta-gamma-dimer, allowing them to interact with effectors molecules and propagate signaling cascades associated with cellular growth, survival, migration, and invasion. Deactivation of the G-protein signaling controlled by the RGS domain accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, which results in the reassociation of the alpha-subunit with the beta-gamma-dimer and thereby inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins are also involved in apoptosis and cell proliferation, as well as modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play important roles in neuronal signals modulation. Some RGS proteins are principal elements needed for proper vision.


Pssm-ID: 188659 [Multi-domain]  Cd Length: 113  Bit Score: 82.82  E-value: 9.54e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158534077  857 LNNKLEFEHFRQFLETHSSSMDLMCWTDIEQFRRITYRDRnQRKAKSIYIKNKYLNKKYFFGPNSPASLyqQNQVMHlsg 936
Cdd:cd07440     1 LRDPYGLEYFRQFLKSEHCEENLEFWLAVEKFKKTTSSDE-ELKSKAKEIYDKYISKDAPKEINIPESI--REEIEE--- 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 158534077  937 gwgKILHEQLDAPVLVEIQKHVQNRLENVWLPLFLASEQF 976
Cdd:cd07440    75 ---NLEEPYPDPDCFDEAQEHILNLLEKDSYPRFLKSDLY 111
RGS smart00315
Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins ...
 1022-1136 1.23e-12

Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 214613  Cd Length: 118  Bit Score: 65.75  E-value: 1.23e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158534077   1022 FRKALLNPVTSRQFQRFvaLKGDLLENGLLFWQEVQKYKDLchshCDESVIQKKITTIINCFINSSIPPALQIDI-PVEQ 1100
Cdd:smart00315    2 LESLLSDPIGRLLFREF--LESEFSEENLEFWLAVEEFKKA----EDDEERIAKAREIYDKFLSPNAPKEVNLDSdLREK 75

                            90       100       110
                    ....*....|....*....|....*....|....*..
gi 158534077   1101 AQKIIEHRkELGPYVFREAQMTIFGVL-FKFWPQFCE 1136
Cdd:smart00315   76 IEENLESE-EPPPDLFDEAQREVYELLeKDSFPRFLE 111
RGS cd07440
Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part ...
 676-782 9.44e-11

Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. While inactive, G-alpha-subunits bind GDP, which is released and replaced by GTP upon agonist activation. GTP binding leads to dissociation of the alpha-subunit and the beta-gamma-dimer, allowing them to interact with effectors molecules and propagate signaling cascades associated with cellular growth, survival, migration, and invasion. Deactivation of the G-protein signaling controlled by the RGS domain accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, which results in the reassociation of the alpha-subunit with the beta-gamma-dimer and thereby inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins are also involved in apoptosis and cell proliferation, as well as modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play important roles in neuronal signals modulation. Some RGS proteins are principal elements needed for proper vision.


Pssm-ID: 188659 [Multi-domain]  Cd Length: 113  Bit Score: 60.10  E-value: 9.44e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158534077  676 FFFTKFCEHSGNKlwkNSVYFWFDLQAYHQLFYQETlqpfKVCKQAQYLFATYVAPSATLDIGLQQEKKKEIYMKIQPP- 754
Cdd:cd07440     8 EYFRQFLKSEHCE---ENLEFWLAVEKFKKTTSSDE----ELKSKAKEIYDKYISKDAPKEINIPESIREEIEENLEEPy 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 158534077  755 -FEDLFDTAEEYILLL-LLEPWTKMVKSDQ 782
Cdd:cd07440    81 pDPDCFDEAQEHILNLlEKDSYPRFLKSDL 110
RGS pfam00615
Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for ...
 852-976 1.71e-07

Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 459870  Cd Length: 117  Bit Score: 51.08  E-value: 1.71e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158534077   852 KFSDLLNNKLEFEHFRQFLETHSSSMDLMCWTDIEQFRRITYRDRNQRKAKSIYikNKYLNkkyffgPNSPASLYQQNQV 931
Cdd:pfam00615    1 SFDSLLEDQPGRRLFRQFLESEFSEENLEFWLACEEFKKADPDEERLKKAKEIY--NEFLA------PGSPKEINLDSDL 72

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 158534077   932 M-HLSGGwgkiLHEQLDAPVLVEIQKHVQNRLENVWLPLFLASEQF 976
Cdd:pfam00615   73 ReEIREN----LEKEPTRDLFDEAQAEVYELMEKDSYPRFLKSPLY 114
RGS cd07440
Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part ...
 1026-1141 2.71e-07

Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. While inactive, G-alpha-subunits bind GDP, which is released and replaced by GTP upon agonist activation. GTP binding leads to dissociation of the alpha-subunit and the beta-gamma-dimer, allowing them to interact with effectors molecules and propagate signaling cascades associated with cellular growth, survival, migration, and invasion. Deactivation of the G-protein signaling controlled by the RGS domain accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, which results in the reassociation of the alpha-subunit with the beta-gamma-dimer and thereby inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins are also involved in apoptosis and cell proliferation, as well as modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play important roles in neuronal signals modulation. Some RGS proteins are principal elements needed for proper vision.


Pssm-ID: 188659 [Multi-domain]  Cd Length: 113  Bit Score: 50.47  E-value: 2.71e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158534077 1026 LLNPVTSRQFQRFVALKGDllENGLLFWQEVQKYKDLCHShcdESVIQKKITTIINCFINSSIPPALQIDipvEQAQKII 1105
Cdd:cd07440     1 LRDPYGLEYFRQFLKSEHC--EENLEFWLAVEKFKKTTSS---DEELKSKAKEIYDKYISKDAPKEINIP---ESIREEI 72

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 158534077 1106 EHR---KELGPYVFREAQMTIFGVLFK-FWPQFCEFRKNL 1141
Cdd:cd07440    73 EENleePYPDPDCFDEAQEHILNLLEKdSYPRFLKSDLYL 112
RGS smart00315
Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins ...
 852-976 5.31e-06

Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 214613  Cd Length: 118  Bit Score: 46.88  E-value: 5.31e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158534077    852 KFSDLLNNKLEFEHFRQFLETHSSSMDLMCWTDIEQFRRITYRDRNQRKAKSIYIKnkylnkkyFFGPNSPASLYQQNQV 931
Cdd:smart00315    1 SLESLLSDPIGRLLFREFLESEFSEENLEFWLAVEEFKKAEDDEERIAKAREIYDK--------FLSPNAPKEVNLDSDL 72

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*.
gi 158534077    932 M-HLSGGwgkILHEQLDAPVLVEIQKHVQNRLENVWLPLFLASEQF 976
Cdd:smart00315   73 ReKIEEN---LESEEPPPDLFDEAQREVYELLEKDSFPRFLESDYY 115
RGS-like_2 cd08728
Uncharacterized Regulator of G protein Signaling (RGS) domain subfamily, child 2; These ...
 857-1039 9.58e-06

Uncharacterized Regulator of G protein Signaling (RGS) domain subfamily, child 2; These uncharacterized RGS-like domains consists largely of hypothetical proteins. The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play an important role in neuronal signal modulation. Some RGS proteins are the principal elements needed for proper vision.


Pssm-ID: 188683  Cd Length: 179  Bit Score: 47.53  E-value: 9.58e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158534077  857 LNNKLEFEHFRQFLETHSSSMDLMCWTDIEQFRRITYRDRNQRKAKSIYiknkylnKKYFFGPNSPASLYQQNQVMhlsg 936
Cdd:cd08728     1 LRNHTHLEYFKRFLKSRGSDGPLLFWIAVEKMRVEENEKEQKAKIELIV-------KRYFHGQDPPGVLLQCEAII---- 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158534077  937 gwgkILHEQLDAPV----LVEIQKHVQNRLENVWLPLFlaSEQFAARQkIKVQMKDIAEELLLQKAEKKIGVWKPVESKW 1012
Cdd:cd08728    70 ----IREIAMMKVVttsmLLSIQHLVSKSLEERWFKKY--QDTFPDCP-HEVEPDEEIKVPLKPTKLKAPHVISSQKRAW 142

                         170       180       190
                  ....*....|....*....|....*....|
gi 158534077 1013 ---ISSSCKIIAFRKALLNPVTSRQFQRFV 1039
Cdd:cd08728   143 eifISFIRSFIKFRRFMVNREIRQEFEDYL 172
RGS pfam00615
Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for ...
 1022-1124 3.43e-04

Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 459870  Cd Length: 117  Bit Score: 41.45  E-value: 3.43e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158534077  1022 FRKALLNPVTSRQFQRFvaLKGDLLENGLLFWQEVQKYKdlchSHCDESVIQKKITTIINCFINSSIPPALQIDipvEQA 1101
Cdd:pfam00615    2 FDSLLEDQPGRRLFRQF--LESEFSEENLEFWLACEEFK----KADPDEERLKKAKEIYNEFLAPGSPKEINLD---SDL 72

                           90       100
                   ....*....|....*....|....*
gi 158534077  1102 QKIIEHR--KELGPYVFREAQMTIF 1124
Cdd:pfam00615   73 REEIRENleKEPTRDLFDEAQAEVY 97
RGS_R7-like cd08705
Regulator of G protein signaling (RGS) domain found in the R7 subfamily of proteins; The RGS ...
 1020-1124 2.19e-03

Regulator of G protein signaling (RGS) domain found in the R7 subfamily of proteins; The RGS (Regulator of G-protein Signaling) domain is an essential part of the R7 (Neuronal RGS) protein subfamily of the RGS protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. The R7 subfamily includes RGS6, RGS7, RGS9, and RGS11, all of which, in humans, are expressed predominantly in the nervous system, form an obligatory complex with G-beta-5, and play important roles in the regulation of crucial neuronal processes. In addition, R7 proteins were found to bind many other proteins outside of the G protein signaling pathways including: m-opioid receptor, beta-arrestin, alpha-actinin-2, NMDAR, polycystin, spinophilin, guanylyl cyclase, among others.


Pssm-ID: 188660  Cd Length: 121  Bit Score: 39.14  E-value: 2.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158534077 1020 IAFRKALLNPVTSRQFQRFvaLKGDLLENGLLFWQEVQKYKdlchsHCDESVIQKKITTIINCFINSSIPPALQIDIPV- 1098
Cdd:cd08705     7 FSFSELLKDPVGREQFLKF--LEKEFSGENLRFWEACQDLK-----YGPQSQVPEKVQEIYQEFLAPGAPSWINIDSKTm 79

                          90       100
                  ....*....|....*....|....*.
gi 158534077 1099 EQAQKIIEHRkelGPYVFREAQMTIF 1124
Cdd:cd08705    80 EITLKNLKDP---HRYTFDAAQEHIY 102
RGS_R12-like cd08706
Regulator of G protein signaling (RGS) domain found in the R12 subfamily of proteins; The RGS ...
 1022-1130 2.58e-03

Regulator of G protein signaling (RGS) domain found in the R12 subfamily of proteins; The RGS (Regulator of G-protein Signaling) domain is an essential part of the R12 (Neuronal RGS) protein subfamily of the RGS protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play a critical regulatory role as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. Deactivation of G-protein signaling, controlled by RGS domain, accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP that results in reassociation of the alpha-subunit with the beta-gamma-dimer and thereby inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. The R12 RGS subfamily includes RGS10, RGS12 and RGS14 all of which are highly selective for G-alpha-i1 over G-alpha-q.


Pssm-ID: 188661  Cd Length: 113  Bit Score: 38.84  E-value: 2.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158534077 1022 FRKALLNPVTSRQFQRFvaLKGDLLENGLLFWQEVQKYKDLchshCDESVIQKKITTIINCFINSSIPPALQIDipvEQA 1101
Cdd:cd08706     1 FERLLQDPVGVKYFTEF--LKKEFSEENILFWQACEKFKKI----PDKKQLVQEAREIYDTFLSSKASSPVNID---SQA 71

                          90       100
                  ....*....|....*....|....*....
gi 158534077 1102 QKIIEHRKELGPYVFREAQMTIFGvLFKF 1130
Cdd:cd08706    72 QLAEEMLEEPHPDMFQKQQLQIFN-LMKF 99
RGS_RGS13 cd08716
Regulator of G protein signaling (RGS) domain found in the RGS13 protein; The RGS (Regulator ...
 683-766 3.45e-03

Regulator of G protein signaling (RGS) domain found in the RGS13 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS13 protein. RGS13 is member of the R4/RGS subfamily of the RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS13 is predominantly expressed in T and B lymphocytes and in mast cells, and plays a role in adaptive immune responses. RGS13 also found in Rgs13, which is also expressed in dendritic cells and in neuroendocrine cells of the thymus, gastrointestinal, and respiratory tracts. Outside of the GPCR pathway, RGS5 interacts with the PIP3 protein.


Pssm-ID: 188671  Cd Length: 114  Bit Score: 38.75  E-value: 3.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158534077  683 EHSgnklwKNSVYFWFDLQAYHQLFYQetlqpFKVCKQAQYLFATYVAPSATLDIGLQQEKKKEIYMKIQPPFEDLFDTA 762
Cdd:cd08716    21 EHS-----DENIEFWLACETYKKIASQ-----RKRISMARKLFASYIQPQAPREINIDSPTRKAIIRNIQEPTQSCFDEA 90


                  ....
gi 158534077  763 EEYI 766
Cdd:cd08716    91 QRIV 94
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH