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Conserved domains on  [gi|7706244|ref|NP_057005|]
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protein CutA isoform 1 [Homo sapiens]

Protein Classification

divalent-cation tolerance protein CutA( domain architecture ID 10503769)

divalent-cation tolerance protein CutA is a cytoplasmic protein implicated in regulating intracellular metal homeostasis

CATH:  3.30.70.120
Gene Symbol:  cutA
Gene Ontology:  GO:0010038
SCOP:  4002632

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CutA1 pfam03091
CutA1 divalent ion tolerance protein; Several gene loci with a possible involvement in ...
 49-143 1.09e-53

CutA1 divalent ion tolerance protein; Several gene loci with a possible involvement in cellular tolerance to copper have been identified. One such locus in eubacteria and archaebacteria, cutA, is thought to be involved in cellular tolerance to a wide variety of divalent cations other than copper. The cutA locus consists of two operons, of one and two genes. The CutA1 protein is a cytoplasmic protein, encoded by the single-gene operon and has been linked to divalent cation tolerance. It has no recognized structural motifs. This family also contains putative proteins from eukaryotes (human and Drosophila).


:

Pssm-ID: 460800  Cd Length: 98  Bit Score: 164.54  E-value: 1.09e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706244     49 FVTCPNEKVAKEIARAVVEKRLAACVNLIPQITSIYEWKGKIEEDSEVLMMIKTQSSLVPALTDFVRSVHPYEVAEVIAL 128
Cdd:pfam03091   3 YTTAPDEEEAEKIARALVEERLAACVNILPGITSIYRWEGKIEEDEEVLLLIKTRASLVDALEARIRELHPYEVPEIIAL 82

                          90
                  ....*....|....*
gi 7706244    129 PVEQGNFPYLQWVRQ 143
Cdd:pfam03091  83 PIEAGNPDYLDWIRE 97
 
Name Accession Description Interval E-value
CutA1 pfam03091
CutA1 divalent ion tolerance protein; Several gene loci with a possible involvement in ...
 49-143 1.09e-53

CutA1 divalent ion tolerance protein; Several gene loci with a possible involvement in cellular tolerance to copper have been identified. One such locus in eubacteria and archaebacteria, cutA, is thought to be involved in cellular tolerance to a wide variety of divalent cations other than copper. The cutA locus consists of two operons, of one and two genes. The CutA1 protein is a cytoplasmic protein, encoded by the single-gene operon and has been linked to divalent cation tolerance. It has no recognized structural motifs. This family also contains putative proteins from eukaryotes (human and Drosophila).


Pssm-ID: 460800  Cd Length: 98  Bit Score: 164.54  E-value: 1.09e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706244     49 FVTCPNEKVAKEIARAVVEKRLAACVNLIPQITSIYEWKGKIEEDSEVLMMIKTQSSLVPALTDFVRSVHPYEVAEVIAL 128
Cdd:pfam03091   3 YTTAPDEEEAEKIARALVEERLAACVNILPGITSIYRWEGKIEEDEEVLLLIKTRASLVDALEARIRELHPYEVPEIIAL 82

                          90
                  ....*....|....*
gi 7706244    129 PVEQGNFPYLQWVRQ 143
Cdd:pfam03091  83 PIEAGNPDYLDWIRE 97
CutA1 COG1324
Divalent cation tolerance protein CutA [Inorganic ion transport and metabolism];
49-145 2.54e-52

Divalent cation tolerance protein CutA [Inorganic ion transport and metabolism];


Pssm-ID: 440935  Cd Length: 104  Bit Score: 161.50  E-value: 2.54e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706244   49 FVTCPNEKVAKEIARAVVEKRLAACVNLIPQITSIYEWKGKIEEDSEVLMMIKTQSSLVPALTDFVRSVHPYEVAEVIAL 128
Cdd:COG1324   7 LTTAPDEEEAERIARALVEERLAACVNILPPITSVYRWQGKIEEDEEVLLLIKTTAERYDALEARIKELHPYEVPEIIAL 86

                        90
                ....*....|....*..
gi 7706244  129 PVEQGNFPYLQWVRQVT 145
Cdd:COG1324  87 PIEAGNPAYLDWIREET 103
dival_cat_tol_CutA NF041095
divalent-cation tolerance protein CutA;
49-145 9.61e-41

divalent-cation tolerance protein CutA;


Pssm-ID: 469021  Cd Length: 100  Bit Score: 131.99  E-value: 9.61e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706244    49 FVTCPNEKVAKEIARAVVEKRLAACVNLIpQITSIYEWKGKIEEDSEVLMMIKTQSSLVPALTDFVRSVHPYEVAEVIAL 128
Cdd:NF041095   5 YTTFPDEESAKEIARKLLEERLIACVNLR-EIRSMYWWKGKIEEDKEVGAILKTTKERWEELKEELKELHPYEVPAILVI 83

                         90
                 ....*....|....*..
gi 7706244   129 PVEQGNFPYLQWVRQVT 145
Cdd:NF041095  84 EVEDVNKEYLSWLDEST 100
PRK10645 PRK10645
divalent cation tolerance protein CutA;
51-141 7.08e-28

divalent cation tolerance protein CutA;


Pssm-ID: 182614  Cd Length: 112  Bit Score: 99.85  E-value: 7.08e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706244    51 TCPNEKVAKEIARAVVEKRLAACVNLIPQITSIYEWKGKIEEDSEVLMMIKTQSSLVPALTDFVRSVHPYEVAEVIALPV 130
Cdd:PRK10645  17 TAPDEATAQDLAAKVLAEKLAACVTLLPGATSLYYWEGKLEQEYEVQMLLKTTVSHQQALLECLKSHHPYQTPELLVLPV 96

                         90
                 ....*....|.
gi 7706244   131 EQGNFPYLQWV 141
Cdd:PRK10645  97 THGDTDYLSWL 107
 
Name Accession Description Interval E-value
CutA1 pfam03091
CutA1 divalent ion tolerance protein; Several gene loci with a possible involvement in ...
 49-143 1.09e-53

CutA1 divalent ion tolerance protein; Several gene loci with a possible involvement in cellular tolerance to copper have been identified. One such locus in eubacteria and archaebacteria, cutA, is thought to be involved in cellular tolerance to a wide variety of divalent cations other than copper. The cutA locus consists of two operons, of one and two genes. The CutA1 protein is a cytoplasmic protein, encoded by the single-gene operon and has been linked to divalent cation tolerance. It has no recognized structural motifs. This family also contains putative proteins from eukaryotes (human and Drosophila).


Pssm-ID: 460800  Cd Length: 98  Bit Score: 164.54  E-value: 1.09e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706244     49 FVTCPNEKVAKEIARAVVEKRLAACVNLIPQITSIYEWKGKIEEDSEVLMMIKTQSSLVPALTDFVRSVHPYEVAEVIAL 128
Cdd:pfam03091   3 YTTAPDEEEAEKIARALVEERLAACVNILPGITSIYRWEGKIEEDEEVLLLIKTRASLVDALEARIRELHPYEVPEIIAL 82

                          90
                  ....*....|....*
gi 7706244    129 PVEQGNFPYLQWVRQ 143
Cdd:pfam03091  83 PIEAGNPDYLDWIRE 97
CutA1 COG1324
Divalent cation tolerance protein CutA [Inorganic ion transport and metabolism];
49-145 2.54e-52

Divalent cation tolerance protein CutA [Inorganic ion transport and metabolism];


Pssm-ID: 440935  Cd Length: 104  Bit Score: 161.50  E-value: 2.54e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706244   49 FVTCPNEKVAKEIARAVVEKRLAACVNLIPQITSIYEWKGKIEEDSEVLMMIKTQSSLVPALTDFVRSVHPYEVAEVIAL 128
Cdd:COG1324   7 LTTAPDEEEAERIARALVEERLAACVNILPPITSVYRWQGKIEEDEEVLLLIKTTAERYDALEARIKELHPYEVPEIIAL 86

                        90
                ....*....|....*..
gi 7706244  129 PVEQGNFPYLQWVRQVT 145
Cdd:COG1324  87 PIEAGNPAYLDWIREET 103
dival_cat_tol_CutA NF041095
divalent-cation tolerance protein CutA;
49-145 9.61e-41

divalent-cation tolerance protein CutA;


Pssm-ID: 469021  Cd Length: 100  Bit Score: 131.99  E-value: 9.61e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706244    49 FVTCPNEKVAKEIARAVVEKRLAACVNLIpQITSIYEWKGKIEEDSEVLMMIKTQSSLVPALTDFVRSVHPYEVAEVIAL 128
Cdd:NF041095   5 YTTFPDEESAKEIARKLLEERLIACVNLR-EIRSMYWWKGKIEEDKEVGAILKTTKERWEELKEELKELHPYEVPAILVI 83

                         90
                 ....*....|....*..
gi 7706244   129 PVEQGNFPYLQWVRQVT 145
Cdd:NF041095  84 EVEDVNKEYLSWLDEST 100
PRK10645 PRK10645
divalent cation tolerance protein CutA;
51-141 7.08e-28

divalent cation tolerance protein CutA;


Pssm-ID: 182614  Cd Length: 112  Bit Score: 99.85  E-value: 7.08e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706244    51 TCPNEKVAKEIARAVVEKRLAACVNLIPQITSIYEWKGKIEEDSEVLMMIKTQSSLVPALTDFVRSVHPYEVAEVIALPV 130
Cdd:PRK10645  17 TAPDEATAQDLAAKVLAEKLAACVTLLPGATSLYYWEGKLEQEYEVQMLLKTTVSHQQALLECLKSHHPYQTPELLVLPV 96

                         90
                 ....*....|.
gi 7706244   131 EQGNFPYLQWV 141
Cdd:PRK10645  97 THGDTDYLSWL 107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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