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Conserved domains on  [gi|17402914|ref|NP_057171|]
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protein Wnt-16 isoform 2 [Homo sapiens]

Protein Classification

wnt family protein( domain architecture ID 14443626)

wnt family protein function in both normal development and differentiation as well as in mammary tumorigenesis

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Wnt_Wnt16 cd19344
Wnt domain found in protein Wnt-16 and similar proteins; Wnt-16 is a mixed canonical and ...
42-355 0e+00

Wnt domain found in protein Wnt-16 and similar proteins; Wnt-16 is a mixed canonical and noncanonical Wnt ligand involved in the regulation of postnatal bone homeostasis. It promotes bone formation and inhibits bone resorption. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


:

Pssm-ID: 381718  Cd Length: 306  Bit Score: 566.48  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914  42 LNSRQKELCKRKPYLLPSIREGARLGIQECGSQFRHERWNCMITAAATtapmgaspLFGYELSSGTKETAFIYAVMAAGL 121
Cdd:cd19344   1 LVSQQRRLCKKKPEAIPSVSEGARLGIYECQHQFRHERWNCSTTNDQN--------VFGKTLSRGTKETAFIYAITSAGV 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914 122 VHSVTRSCSAGNMTECSCDTTLQnGGSASEGWHWGGCSDDVQYGMWFSRKFLDFPIGNTTGKENKVLLAMNLHNNEAGRQ 201
Cdd:cd19344  73 VHAVTRACSAGNLTDCSCDSRRQ-GQSASEGWKWGGCSDNVDYGIWFARKFVDAPEKSERKRSRDVRSLMNLHNNEVGRQ 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914 202 AVAKLMSVDCRCHGVSGSCAVKTCWKTMSSFEKIGHLLKDKYENSIQIS-DKTKRKMRRREKDQRKIPIHKDDLLYVNKS 280
Cdd:cd19344 152 AIARLMKVKCRCHGVSGSCEVKTCWKTMPSFEEVGDFLKQKYENSIQIAtKKSKRRLRRRERRKRKVPISKDELVYIHKS 231
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17402914 281 PNYCVEDKKLGIPGTQGRECNRTSEGADGCNLLCCGRGYNTHVVRHVERCECKFIWCCYVRCRRCESMTDVHTCK 355
Cdd:cd19344 232 PNYCVRDPKKGILGTSGRECNRTSTGPDSCDLLCCGRGYNTQVVRHVERCNCKFVWCCYVKCKTCETMTDVHTCK 306
 
Name Accession Description Interval E-value
Wnt_Wnt16 cd19344
Wnt domain found in protein Wnt-16 and similar proteins; Wnt-16 is a mixed canonical and ...
42-355 0e+00

Wnt domain found in protein Wnt-16 and similar proteins; Wnt-16 is a mixed canonical and noncanonical Wnt ligand involved in the regulation of postnatal bone homeostasis. It promotes bone formation and inhibits bone resorption. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381718  Cd Length: 306  Bit Score: 566.48  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914  42 LNSRQKELCKRKPYLLPSIREGARLGIQECGSQFRHERWNCMITAAATtapmgaspLFGYELSSGTKETAFIYAVMAAGL 121
Cdd:cd19344   1 LVSQQRRLCKKKPEAIPSVSEGARLGIYECQHQFRHERWNCSTTNDQN--------VFGKTLSRGTKETAFIYAITSAGV 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914 122 VHSVTRSCSAGNMTECSCDTTLQnGGSASEGWHWGGCSDDVQYGMWFSRKFLDFPIGNTTGKENKVLLAMNLHNNEAGRQ 201
Cdd:cd19344  73 VHAVTRACSAGNLTDCSCDSRRQ-GQSASEGWKWGGCSDNVDYGIWFARKFVDAPEKSERKRSRDVRSLMNLHNNEVGRQ 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914 202 AVAKLMSVDCRCHGVSGSCAVKTCWKTMSSFEKIGHLLKDKYENSIQIS-DKTKRKMRRREKDQRKIPIHKDDLLYVNKS 280
Cdd:cd19344 152 AIARLMKVKCRCHGVSGSCEVKTCWKTMPSFEEVGDFLKQKYENSIQIAtKKSKRRLRRRERRKRKVPISKDELVYIHKS 231
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17402914 281 PNYCVEDKKLGIPGTQGRECNRTSEGADGCNLLCCGRGYNTHVVRHVERCECKFIWCCYVRCRRCESMTDVHTCK 355
Cdd:cd19344 232 PNYCVRDPKKGILGTSGRECNRTSTGPDSCDLLCCGRGYNTQVVRHVERCNCKFVWCCYVKCKTCETMTDVHTCK 306
wnt pfam00110
wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, ...
42-355 7.56e-167

wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, unicellular eukaryotes or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families.


Pssm-ID: 459677  Cd Length: 307  Bit Score: 467.41  E-value: 7.56e-167
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914    42 LNSRQKELCKRKPYLLPSIREGARLGIQECGSQFRHERWNCmitaaatTAPMGASPLFGYELSSGTKETAFIYAVMAAGL 121
Cdd:pfam00110   5 LSPRQRRLCRRNPDVMASVAEGAQLAIEECQHQFRNRRWNC-------STLENKRPVFGKVLKRGTRETAFVYAISSAGV 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914   122 VHSVTRSCSAGNMTECSCDTTLQNGGSASEGWHWGGCSDDVQYGMWFSRKFLDFPIgnTTGKENKVLlaMNLHNNEAGRQ 201
Cdd:pfam00110  78 THAVTRACSSGELTSCGCDRKKRGKSSGEGGWEWGGCSDNIDYGYKFSRKFVDARE--KKRRDARAL--MNLHNNEAGRK 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914   202 AVAKLMSVDCRCHGVSGSCAVKTCWKTMSSFEKIGHLLKDKYENSIQISDKTKRKMRRREKDQRKIPIHKDDLLYVNKSP 281
Cdd:pfam00110 154 AVKSNMRTECKCHGVSGSCSVKTCWKALPPFREVGDRLKEKYDGAVKVNRRRNKRGRLVPRNSRFKPPTKNDLVYLEKSP 233
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17402914   282 NYCVEDKKLGIPGTQGRECNRTSEGADGCNLLCCGRGYNTHVVRHVERCECKFIWCCYVRCRRCESMTDVHTCK 355
Cdd:pfam00110 234 DYCERNPKTGSLGTRGRECNKTSSGPDGCDLLCCGRGYNTRTVTVTERCNCKFHWCCYVKCKTCTETVEVYTCK 307
WNT1 smart00097
found in Wnt-1;
42-355 3.51e-132

found in Wnt-1;


Pssm-ID: 128408  Cd Length: 305  Bit Score: 379.36  E-value: 3.51e-132
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914     42 LNSRQKELCKRKPYLLPSIREGARLGIQECGSQFRHERWNCmitaaaTTApmGASPLFGYELSSGTKETAFIYAVMAAGL 121
Cdd:smart00097   5 LSRRQRRLCRANPDVMISVAEGAQEGIEECQHQFRFRRWNC------STL--DNASVFGKVLRQGTRETAFVYAISSAGV 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914    122 VHSVTRSCSAGNMTECSCDTTLqNGGSASEGWHWGGCSDDVQYGMWFSRKFLDfpignTTGKENKVLLAMNLHNNEAGRQ 201
Cdd:smart00097  77 AHAVTRACSEGELDSCGCDYRK-RGRAGGRGWKWGGCSDNIDFGIRFSREFVD-----ARERGKDARALMNLHNNEAGRL 150
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914    202 AVAKLMSVDCRCHGVSGSCAVKTCWKTMSSFEKIGHLLKDKYENSIQISDKTKRKMR-RREKDQRKIPIHKDDLLYVNKS 280
Cdd:smart00097 151 AVKKTMKRECKCHGVSGSCTVKTCWLQLPDFRKVGDYLKEKYDGASEVEVDKRGTNKaPVPKNSTFKPPTETDLVYLESS 230
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17402914    281 PNYCVEDKKLGIPGTQGRECNRTSEGADGCNLLCCGRGYNTHVVRHVERCECKFIWCCYVRCRRCESMTDVHTCK 355
Cdd:smart00097 231 PDFCEKNPKTGSLGTQGRQCNKTSKGLDGCDLLCCGRGYNTRTVEVVERCNCKFHWCCYVKCKQCRETVEKHTCK 305
 
Name Accession Description Interval E-value
Wnt_Wnt16 cd19344
Wnt domain found in protein Wnt-16 and similar proteins; Wnt-16 is a mixed canonical and ...
42-355 0e+00

Wnt domain found in protein Wnt-16 and similar proteins; Wnt-16 is a mixed canonical and noncanonical Wnt ligand involved in the regulation of postnatal bone homeostasis. It promotes bone formation and inhibits bone resorption. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381718  Cd Length: 306  Bit Score: 566.48  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914  42 LNSRQKELCKRKPYLLPSIREGARLGIQECGSQFRHERWNCMITAAATtapmgaspLFGYELSSGTKETAFIYAVMAAGL 121
Cdd:cd19344   1 LVSQQRRLCKKKPEAIPSVSEGARLGIYECQHQFRHERWNCSTTNDQN--------VFGKTLSRGTKETAFIYAITSAGV 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914 122 VHSVTRSCSAGNMTECSCDTTLQnGGSASEGWHWGGCSDDVQYGMWFSRKFLDFPIGNTTGKENKVLLAMNLHNNEAGRQ 201
Cdd:cd19344  73 VHAVTRACSAGNLTDCSCDSRRQ-GQSASEGWKWGGCSDNVDYGIWFARKFVDAPEKSERKRSRDVRSLMNLHNNEVGRQ 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914 202 AVAKLMSVDCRCHGVSGSCAVKTCWKTMSSFEKIGHLLKDKYENSIQIS-DKTKRKMRRREKDQRKIPIHKDDLLYVNKS 280
Cdd:cd19344 152 AIARLMKVKCRCHGVSGSCEVKTCWKTMPSFEEVGDFLKQKYENSIQIAtKKSKRRLRRRERRKRKVPISKDELVYIHKS 231
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17402914 281 PNYCVEDKKLGIPGTQGRECNRTSEGADGCNLLCCGRGYNTHVVRHVERCECKFIWCCYVRCRRCESMTDVHTCK 355
Cdd:cd19344 232 PNYCVRDPKKGILGTSGRECNRTSTGPDSCDLLCCGRGYNTQVVRHVERCNCKFVWCCYVKCKTCETMTDVHTCK 306
wnt pfam00110
wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, ...
42-355 7.56e-167

wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, unicellular eukaryotes or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families.


Pssm-ID: 459677  Cd Length: 307  Bit Score: 467.41  E-value: 7.56e-167
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914    42 LNSRQKELCKRKPYLLPSIREGARLGIQECGSQFRHERWNCmitaaatTAPMGASPLFGYELSSGTKETAFIYAVMAAGL 121
Cdd:pfam00110   5 LSPRQRRLCRRNPDVMASVAEGAQLAIEECQHQFRNRRWNC-------STLENKRPVFGKVLKRGTRETAFVYAISSAGV 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914   122 VHSVTRSCSAGNMTECSCDTTLQNGGSASEGWHWGGCSDDVQYGMWFSRKFLDFPIgnTTGKENKVLlaMNLHNNEAGRQ 201
Cdd:pfam00110  78 THAVTRACSSGELTSCGCDRKKRGKSSGEGGWEWGGCSDNIDYGYKFSRKFVDARE--KKRRDARAL--MNLHNNEAGRK 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914   202 AVAKLMSVDCRCHGVSGSCAVKTCWKTMSSFEKIGHLLKDKYENSIQISDKTKRKMRRREKDQRKIPIHKDDLLYVNKSP 281
Cdd:pfam00110 154 AVKSNMRTECKCHGVSGSCSVKTCWKALPPFREVGDRLKEKYDGAVKVNRRRNKRGRLVPRNSRFKPPTKNDLVYLEKSP 233
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17402914   282 NYCVEDKKLGIPGTQGRECNRTSEGADGCNLLCCGRGYNTHVVRHVERCECKFIWCCYVRCRRCESMTDVHTCK 355
Cdd:pfam00110 234 DYCERNPKTGSLGTRGRECNKTSSGPDGCDLLCCGRGYNTRTVTVTERCNCKFHWCCYVKCKTCTETVEVYTCK 307
Wnt cd13113
Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary ...
56-354 9.18e-142

Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary tumor virus (MMTV) integration site family; Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about the structure of Wnt proteins, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. Wnt signaling mediated by Wnt proteins orchestrates and influences a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381706  Cd Length: 288  Bit Score: 403.21  E-value: 9.18e-142
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914  56 LLPSIREGARLGIQECGSQFRHERWNCMITAAattapmgaSPLFGYELSSGTKETAFIYAVMAAGLVHSVTRSCSAGNMT 135
Cdd:cd13113   1 LMESIAEGAQLALKECQRQFANRRWNCSTFNE--------PLLFGKILKRGTRETAFVHAITSAGVTHAITRACSRGKLK 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914 136 ECSCDTTLQnGGSASEGWHWGGCSDDVQYGMWFSRKFLDFPIgntTGKENKVLLAMNLHNNEAGRQAVAKLMSVDCRCHG 215
Cdd:cd13113  73 NCGCDRTRQ-GPEGQGDWTWGGCSDNIKFGIKFSRKFLDARE---KKKGSDARSLMNLHNNEAGRKAVKKTMKKKCKCHG 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914 216 VSGSCAVKTCWKTMSSFEKIGHLLKDKYENSIQI-SDKTKRKMRRREKDQRKIPIHKDDLLYVNKSPNYCVEDKKLGIPG 294
Cdd:cd13113 149 VSGSCTTKTCWRQLPSFREIGDYLKEKYDNAVKVkLNNNGSGLRLVPKRSRFRSPTETDLVYLEESPDYCEPNPTLGSLG 228
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914 295 TQGRECNRTSEGADGCNLLCCGRGYNTHVVRHVERCECKFIWCCYVRCRRCESMTDVHTC 354
Cdd:cd13113 229 TAGRECNPTSPGPDSCELLCCGRGYRTETEIVTEKCNCKFVWCCEVKCETCRRTVERYTC 288
Wnt_Wnt3_Wnt3a cd19335
Wnt domain found in proto-oncogene Wnt-3 and similar proteins; Wnt-3, also called ...
37-355 2.38e-135

Wnt domain found in proto-oncogene Wnt-3 and similar proteins; Wnt-3, also called proto-oncogene Int-4, functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. It is required for normal embryonic development, and especially for limb development. Wnt-3a functions in the canonical Wnt signaling pathway and plays crucial roles in both proliferation and differentiation processes in several types of stem cells. Wnt3a stimulates the migration and invasion of trophoblasts and induce the survival, proliferation, and migration of human embryonic kidney (HEK) 293 cells. It also up-regulates genes implicated in melanocyte differentiation and increases the expression and nuclear localization of the transcriptional co-activator with PDZ-binding motif (TAZ), a transcriptional modulator involved in activating osteoblastic differentiation. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381709  Cd Length: 314  Bit Score: 387.90  E-value: 2.38e-135
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914  37 CANLP-LNSRQKELCKRKPYLLPSIREGARLGIQECGSQFRHERWNCmitaaaTTAPMGASpLFGYELSSGTKETAFIYA 115
Cdd:cd19335   4 CGSIPgLVPKQLRFCRNYTELMPSVAEGAKLGIQECQHQFRGRRWNC------TTIEGDLS-VFGPVLDKASRESAFVHA 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914 116 VMAAGLVHSVTRSCSAGNMTECSCDTTLQngGSASEGWHWGGCSDDVQYGMWFSRKFLDFPIGNTTGKEnkvllAMNLHN 195
Cdd:cd19335  77 IASAGVAHAVTRACAEGDSTSCGCDSRHK--GPPGEGWRWGGCSEDVEFGVRFSREFADARENRPDARS-----AMNRHN 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914 196 NEAGRQAVAKLMSVDCRCHGVSGSCAVKTCWKTMSSFEKIGHLLKDKYENSIQISDKTKRKMRRREKDQRKIPIH----- 270
Cdd:cd19335 150 NEAGRQAILDNMELKCKCHGLSGSCELKTCWWAQPDFRKIGDYLKDKYDSASEMVVERHRESRGWVETLRPKYKLfkppt 229
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914 271 KDDLLYVNKSPNYCVEDKKLGIPGTQGRECNRTSEGADGCNLLCCGRGYNTHVVRHVERCECKFIWCCYVRCRRCESMTD 350
Cdd:cd19335 230 ERDLIYYEESPNFCEPNPETGSFGTRGRECNVTSHGIDGCDLLCCGRGYNTRTEKRTEKCHCIFVWCCYVSCQECIRVYD 309

                ....*
gi 17402914 351 VHTCK 355
Cdd:cd19335 310 VHTCK 314
Wnt_Wnt11 cd19343
Wnt domain found in protein Wnt-11 and similar proteins; Wnt-11 may be a signaling molecule ...
42-355 6.46e-133

Wnt domain found in protein Wnt-11 and similar proteins; Wnt-11 may be a signaling molecule which has possible roles in the development of skeleton, kidney and lung. It is a positive regulator of the Wnt signaling pathway, which plays a crucial role in carcinogenesis. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381717  Cd Length: 305  Bit Score: 381.22  E-value: 6.46e-133
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914  42 LNSRQKELCKRKPYLLPSIREGARLGIQECGSQFRHERWNC-MITAAattapmgasPLFGYELSSGTKETAFIYAVMAAG 120
Cdd:cd19343   1 LVGDQVKLCRRNLELMPSVVEAARLTVDTCQEQFADRRWNCsSIELA---------PNFTPDLTRGTREQAFVYALSSAA 71
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914 121 LVHSVTRSCSAGNMTECSCDTTlqNGGSASEGWHWGGCSDDVQYGMWFSRKFLDFPIGNTTGKENKVLLAMNLHNNEAGR 200
Cdd:cd19343  72 LTHTIARACASGALPGCGCGRL--PREPPDGDFKWGGCGDNVRYGLRFAKRFTDAPEKKKKKKKRQARALMNLHNNRVGR 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914 201 QAVAKLMSVDCRCHGVSGSCAVKTCWKTMSSFEKIGHLLKDKYENSIQISDKTKRKMRRR-EKDQRKIPIHKDDLLYVNK 279
Cdd:cd19343 150 KAVRDSLETQCKCHGVSGSCSVKTCWKALPDLSEVASRLKRKYARAVEVVSRKVGSRRKLvPKSLKVRPYTKDDLIYLTK 229
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17402914 280 SPNYCVEDKKLGIPGTQGRECNRTSEGADGCNLLCCGRGYNTHVVRHVERCECKFIWCCYVRCRRCESMTDVHTCK 355
Cdd:cd19343 230 SPDYCLPDEKLGSLGTRGRECNKTSVGSDSCDSMCCGRGYRTYTVEVVERCHCKYHWCCYVKCKTCRRTVEVHVCK 305
WNT1 smart00097
found in Wnt-1;
42-355 3.51e-132

found in Wnt-1;


Pssm-ID: 128408  Cd Length: 305  Bit Score: 379.36  E-value: 3.51e-132
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914     42 LNSRQKELCKRKPYLLPSIREGARLGIQECGSQFRHERWNCmitaaaTTApmGASPLFGYELSSGTKETAFIYAVMAAGL 121
Cdd:smart00097   5 LSRRQRRLCRANPDVMISVAEGAQEGIEECQHQFRFRRWNC------STL--DNASVFGKVLRQGTRETAFVYAISSAGV 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914    122 VHSVTRSCSAGNMTECSCDTTLqNGGSASEGWHWGGCSDDVQYGMWFSRKFLDfpignTTGKENKVLLAMNLHNNEAGRQ 201
Cdd:smart00097  77 AHAVTRACSEGELDSCGCDYRK-RGRAGGRGWKWGGCSDNIDFGIRFSREFVD-----ARERGKDARALMNLHNNEAGRL 150
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914    202 AVAKLMSVDCRCHGVSGSCAVKTCWKTMSSFEKIGHLLKDKYENSIQISDKTKRKMR-RREKDQRKIPIHKDDLLYVNKS 280
Cdd:smart00097 151 AVKKTMKRECKCHGVSGSCTVKTCWLQLPDFRKVGDYLKEKYDGASEVEVDKRGTNKaPVPKNSTFKPPTETDLVYLESS 230
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17402914    281 PNYCVEDKKLGIPGTQGRECNRTSEGADGCNLLCCGRGYNTHVVRHVERCECKFIWCCYVRCRRCESMTDVHTCK 355
Cdd:smart00097 231 PDFCEKNPKTGSLGTQGRQCNKTSKGLDGCDLLCCGRGYNTRTVEVVERCNCKFHWCCYVKCKQCRETVEKHTCK 305
Wnt_Wnt7 cd19339
Wnt domain found in protein Wnt-7a, Wnt-7b and similar proteins; The family includes Wnt-7a ...
41-355 2.29e-129

Wnt domain found in protein Wnt-7a, Wnt-7b and similar proteins; The family includes Wnt-7a and Wnt-7b. Wnt-7a acts as a canonical Wnt ligand that modulates the synaptic vesicle cycle and synaptic transmission in hippocampal neurons. It also plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development, and urogenital tract development. Wnt-7b functions in the canonical Wnt/beta-catenin signaling pathway in vascular smooth muscle cells. It is required for normal fusion of the chorion and the allantois during placenta development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381713  Cd Length: 313  Bit Score: 372.78  E-value: 2.29e-129
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914  41 PLNSRQKELCKRKPYLLPSIREGARLGIQECGSQFRHERWNCmitaaatTAPmGASPLFGYELSSGTKETAFIYAVMAAG 120
Cdd:cd19339   7 GLTPRQRAICQSRPDAIVAIGEGAQLGIEECQFQFRNHRWNC-------TLL-GERTVFGQELPVGSREAAFTYAITSAG 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914 121 LVHSVTRSCSAGNMTECSCDTTLQNGGSASEGWHWGGCSDDVQYGMWFSRKFLDfpiGNTTGKENKVLlaMNLHNNEAGR 200
Cdd:cd19339  79 VAYAITQACSQGNLSDCGCDKSKKGYGKSDEGWKWGGCSADVKYGLRFSRKFVD---AREVKRNARSL--MNLHNNEAGR 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914 201 QAVAKLMSVDCRCHGVSGSCAVKTCWKTMSSFEKIGHLLKDKYENSIQIsdKTKRKMRRREKDQRKIPIHKD-------D 273
Cdd:cd19339 154 KAVEENLKLECKCHGVSGSCTTKTCWTTLPSFREIGDYLKKKYERARRV--EPVRGRRRRRPTFLKLKISRKykkprprD 231
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914 274 LLYVNKSPNYCVEDKKLGIPGTQGRECNRTSEGADGCNLLCCGRGYNTHVVRHVERCECKFIWCCYVRCRRCESMTDVHT 353
Cdd:cd19339 232 LVYLEKSPNYCEKDPLTGSLGTVGRRCNRTSTGTDGCDLMCCGRGYNTHQYTKTWQCNCKFHWCCYVKCNTCSERTEEYT 311

                ..
gi 17402914 354 CK 355
Cdd:cd19339 312 CK 313
Wnt_Wnt6 cd19338
Wnt domain found in protein Wnt-6 and similar proteins; Wnt-6 may function as a signaling ...
42-355 4.07e-129

Wnt domain found in protein Wnt-6 and similar proteins; Wnt-6 may function as a signaling molecule which affects the development of discrete regions of tissues. It may promote tumorigenesis in gastrointestinal cancer and cervical cancer. It can compensate for the absence of ectoderm and can induce the formation of muscle cells in the limb. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381712  Cd Length: 310  Bit Score: 371.94  E-value: 4.07e-129
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914  42 LNSRQKELCKRKPYLLPSIREGARLGIQECGSQFRHERWNCMITAAAttapmgasplFGYELSSGTKETAFIYAVMAAGL 121
Cdd:cd19338  13 LKGKQREICRKEPEILEEVAKGAKLGIRECQYQFRNRRWNCSTSRKS----------FGKILKRDTRETAFVYAITSAGV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914 122 VHSVTRSCSAGNMTECSCDTTLqNGGSASEGWHWGGCSDDVQYGMWFSRKFLDFPIGNttGKENKVLlaMNLHNNEAGRQ 201
Cdd:cd19338  83 TYSVTRACSMGELLQCGCDKSK-RGKSTEGEWEWGGCSDNVRYGYRKSREFMDAKEKN--RSDIRTL--MNLHNNEAGRL 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914 202 AVAKLMSVDCRCHGVSGSCAVKTCWKTMSSFEKIGHLLKDKYENSIQ-ISDKTKRKMRRREKDQRKIPihKDDLLYVNKS 280
Cdd:cd19338 158 AVKNNMRKECKCHGLSGSCTLKTCWRKMPPFREVGDRLKERFDGAIKvKGSNDGKSLIPEGKTIKPPT--KEDLVYLEES 235
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17402914 281 PNYCVEDKKLGIPGTQGRECNRTSEGADGCNLLCCGRGYNTHVVRHVERCECKFIWCCYVRCRRCESMTDVHTCK 355
Cdd:cd19338 236 PDFCEPNKKTGSLGTRGRECNRTSMGVDGCDLLCCGRGYQTEVRVVEENCNCRFHWCCEVKCETCKVRKEIHTCN 310
Wnt_Wnt5 cd19337
Wnt domain found in protein Wnt-5a, Wnt-5b and similar proteins; The family includes Wnt-5a ...
37-355 2.76e-125

Wnt domain found in protein Wnt-5a, Wnt-5b and similar proteins; The family includes Wnt-5a and Wnt-5b, both of which are secreted growth factors that belong to the noncanonical members of the Wingless-related MMTV-integration family. Wnt-5a can activate or inhibit canonical Wnt signaling, depending on receptor context. It specifically regulates dendritic spine formation in rodent hippocampal neurons, resulting in postsynaptic development that promotes the clustering of the postsynaptic density protein 95 (PSD-95). The overexpression of Wnt-5b is associated with cancer aggressiveness. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381711  Cd Length: 313  Bit Score: 362.33  E-value: 2.76e-125
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914  37 CANLP-LNSRQKELCKRKPYLLPSIREGARLGIQECGSQFRHERWNCMITaaattapmGASPLFGYELSSGTKETAFIYA 115
Cdd:cd19337   1 CDQLRgLSPGQRKLCQLYQDHMPSVGRGAKLAIEECQYQFRYRRWNCSTP--------DSSSVFGPVTNIGTREAAFTYA 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914 116 VMAAGLVHSVTRSCSAGNMTECSCDTTLQNGGSASEgWHWGGCSDDVQYGMWFSRKFLDF------PIGNTTGKENKVll 189
Cdd:cd19337  73 ISAAGVVHAIARACREGNLSTCGCSRERRPKDLPRD-WLWGGCGDNIEYGYKFAKEFIDAreretnYPRHSRELARVL-- 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914 190 aMNLHNNEAGRQAVAKLMSVDCRCHGVSGSCAVKTCWKTMSSFEKIGHLLKDKYENSIQISDKTKRKMRRREKDQRKIPI 269
Cdd:cd19337 150 -MNLHNNEAGRRAVYEKARVACKCHGVSGSCSLKTCWRQLAPFREVGDRLKDKYDGAVKVKLNRRGTLLRRRNSRFNKPT 228
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914 270 hKDDLLYVNKSPNYCVEDKKLGIPGTQGRECNRTSEGADGCNLLCCGRGYNTHVVRHVERCECKFIWCCYVRCRRCESMT 349
Cdd:cd19337 229 -KDDLVYLDDSPDYCERNPKTGSLGTKGRECNKTSSGTDGCELLCCGRGYNTKKVEVVERCHCKFHWCCEVKCKTCEKIV 307

                ....*.
gi 17402914 350 DVHTCK 355
Cdd:cd19337 308 DVHICK 313
Wnt_Wnt2_like cd19334
Wnt domain found in protein Wnt-2, Wnt-2b and similar proteins; The family includes Wnt-2 and ...
37-355 1.62e-122

Wnt domain found in protein Wnt-2, Wnt-2b and similar proteins; The family includes Wnt-2 and Wnt-2b. Wnt-2, also called Int-1-like protein 1 (INT1L1), or Int-1-related protein (IRP), functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. It plays an important role in embryonic lung development. Wnt-2b, also called protein Wnt-13, functions in the canonical Wnt/beta-catenin signaling pathway. It plays a redundant role in embryonic lung development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381708  Cd Length: 314  Bit Score: 355.49  E-value: 1.62e-122
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914  37 CANLP-LNSRQKELCKRKPYLLPSIREGARLGIQECGSQFRHERWNCmitaaaTTAPMGASpLFGYELSSGTKETAFIYA 115
Cdd:cd19334   6 CDNIPgLVSKQRQLCRKHPDVMVSIGEGAKLGVKECQYQFRNQRWNC------STVDRDAT-VFGKVLLKGSREAAFVYA 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914 116 VMAAGLVHSVTRSCSAGNMTECSCDTTLQNGGSASEG-WHWGGCSDDVQYGMWFSRKFLDfpignttGKENKVLLA---M 191
Cdd:cd19334  79 ISSAGVVHAITRACSKGELLNCACDPTKRGKGRDSKGeFDWGGCSDNVKYGINFARKFVD-------ARERRVRDAralM 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914 192 NLHNNEAGRQAVAKLMSVDCRCHGVSGSCAVKTCWKTMSSFEKIGHLLKDKYENSIQISDKTKRKMRRREKDQRKIPIhK 271
Cdd:cd19334 152 NLHNNRAGRKAVKKNLKLQCKCHGVSGSCTIRTCWRALAEFREVGDYLREKYDGAVQVTMNQSGTNLLAANKGHKKPT-R 230
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914 272 DDLLYVNKSPNYCVEDKKLGIPGTQGRECNRTSEGADGCNLLCCGRGYNTHVVRHVERCECKFIWCCYVRCRRCESMTDV 351
Cdd:cd19334 231 SDLVYFESSPDYCVPNPETGSLGTAGRVCNKTSTGTDGCDIMCCGRGYDTTRVRRTTKCNCKFHWCCQVKCKTCTETVDV 310

                ....
gi 17402914 352 HTCK 355
Cdd:cd19334 311 HTCK 314
Wnt_Wnt4 cd19336
Wnt domain found in protein Wnt-4 and similar proteins; Wnt-4 may function as a signaling ...
37-355 4.33e-121

Wnt domain found in protein Wnt-4 and similar proteins; Wnt-4 may function as a signaling molecule which affects the development of discrete regions of tissues. Its overexpression may be associated with abnormal proliferation in human breast tissue. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381710  Cd Length: 310  Bit Score: 351.62  E-value: 4.33e-121
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914  37 CANLP-LNSRQKELCKRKPYLLPSIREGARLGIQECGSQFRHERWNCmitaaaTTapMGASPLFGYELSSGTKETAFIYA 115
Cdd:cd19336   1 CESLKgLTKRQVQFCKRNLEVMDSVRRGAQLAIEECQFQFRNRRWNC------ST--LDKEPVFGKVLNQGTREAAFVHA 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914 116 VMAAGLVHSVTRSCSAGNMTECSCDTTlQNGGSAsEGWHWGGCSDDVQYGMWFSRKFLDFP-IGNTTGKENKVLlaMNLH 194
Cdd:cd19336  73 ISSAGVAHAVTRACSSGELEKCGCDRS-VRGRSP-EGFQWSGCSDNVAYGVAFSKSFVDAReRRKGRASSSRAL--MNLH 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914 195 NNEAGRQAVAKLMSVDCRCHGVSGSCAVKTCWKTMSSFEKIGHLLKDKYENSiqisdkTKRKMRRREKDQRKIPIH---- 270
Cdd:cd19336 149 NNEAGRKAIEKNMRVECKCHGVSGSCELKTCWRAMPTFREVGNILKEKFDGA------TEVQQKRIGSRPVLVPKNpqfk 222
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914 271 ---KDDLLYVNKSPNYCVEDKKLGIPGTQGRECNRTSEGADGCNLLCCGRGYNTHVVRHVERCECKFIWCCYVRCRRCES 347
Cdd:cd19336 223 phtDADLVYLDSSPDFCEPDPKTGSLGTHGRVCNKTSKAIDGCDLLCCGRGYVTRTEEVVERCSCKFHWCCYVKCKTCRR 302

                ....*...
gi 17402914 348 MTDVHTCK 355
Cdd:cd19336 303 EVEVHTCR 310
Wnt_Wnt10 cd19342
Wnt domain found in protein Wnt-10a, Wnt-10b and similar proteins; The family includes protein ...
37-355 2.11e-114

Wnt domain found in protein Wnt-10a, Wnt-10b and similar proteins; The family includes protein Wnt-10a and Wnt-10b. Wnt-10a plays a role in normal ectoderm development. It is required for normal postnatal development and maintenance of tongue papillae and sweat ducts, as well as normal hair follicle function. Wnt-10b, also called protein Wnt-12, specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. It is involved in signaling networks controlling stemness, pluripotency, and cell fate decisions. Wnt-10b is unique and plays an important role in differentiation of epithelial cells in the hair follicle. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381716  Cd Length: 316  Bit Score: 334.62  E-value: 2.11e-114
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914  37 CANLP-LNSRQKELCKRKPYLLPSIREGARLGIQECGSQFRHERWNCMITAAATTAPMgASPLfgyeLSSGTKETAFIYA 115
Cdd:cd19342   4 CRTFPgLTREQLELCRRYPDVTASAIQGIQLAVHECQRQFRDHRWNCSSLETKNKNPH-TSPI----LSRGYRETAFAYA 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914 116 VMAAGLVHSVTRSCSAGNMTECSCDTTLQNGGSASEGWHWGGCSDDVQYGMWFSRKFLDfpigntTGKENKVLLA-MNLH 194
Cdd:cd19342  79 ISAAGVAHQVARACSLGKLLSCGCDRSRRGKRSSGNDWKWGGCSHNLDFGEKFSRKFLD------SREKARDIHSrMNLH 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914 195 NNEAGRQAVAKLMSVDCRCHGVSGSCAVKTCWKTMSSFEKIGHLLKDKYENSIQIS-----DKTKRKMRRREKDQRKIPi 269
Cdd:cd19342 153 NNRAGRLAVSENMERKCKCHGMSGSCELKTCWKAAPDFREVGDILKEKYDHATLVDqsnlnNGARRRRLTRRKRRRRPP- 231
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914 270 hKDDLLYVNKSPNYCVEDKKLGIPGTQGRECNRTSEGADGCNLLCCGRGYNTHVVRHVERCECKFIWCCYVRCRRCESMT 349
Cdd:cd19342 232 -KTDLVYYERSPNFCEADPSLDSPGTRGRVCNKTSTGPDSCDSLCCGRGYNTVRQTRTERCNCRFHWCCYVVCEKCTETE 310

                ....*.
gi 17402914 350 DVHTCK 355
Cdd:cd19342 311 WVTVCK 316
Wnt_Wnt1 cd19333
Wnt domain found in proto-oncogene Wnt-1 and similar proteins; Wnt-1, also called ...
42-354 7.23e-111

Wnt domain found in proto-oncogene Wnt-1 and similar proteins; Wnt-1, also called proto-oncogene Int-1, acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation. It plays a role in osteoblast function, bone development and bone homeostasis. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381707  Cd Length: 311  Bit Score: 325.46  E-value: 7.23e-111
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914  42 LNSRQKELCKRKPYLLPSIREGARLGIQECGSQFRHERWNCmitaaATTAPMGASPLFGYELSSGTKETAFIYAVMAAGL 121
Cdd:cd19333   1 LTKKQRRLVRQNPGTLHAIARGARMAIKECKWQFRNRRWNC-----PTTDSRGGPNVFGKILNRGCRETAFIYAITSAAV 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914 122 VHSVTRSCSAGNMTECSCDTTLQngGSASEGWHWGGCSDDVQYGMWFSRKFLDfpiGNTTGKENKVLlaMNLHNNEAGRQ 201
Cdd:cd19333  76 THSVARACSEGSIESCSCDYRRR--GPGGPDWEWGGCSDNIDFGRKFSREFVD---AGEKGRDLRYL--MNLHNNEAGRV 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914 202 AVAKLMSVDCRCHGVSGSCAVKTCWKTMSSFEKIGHLLKDKYENS--IQISDKTKRKMRRREKDQRKIPIH-------KD 272
Cdd:cd19333 149 HVSSEMRQECKCHGMSGSCTVKTCWMRLPTFRTVGDRLKDRFDGAsrVAYGNNGNNRGSRRAKKFLLEPENpnhkpptSK 228
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914 273 DLLYVNKSPNYCVEDKKLGIPGTQGRECNRTSEGADGCNLLCCGRGYNTHVVRHVERCECKFIWCCYVRCRRCESMTDVH 352
Cdd:cd19333 229 DLVYFEESPNFCEKNPKLGTLGTRGRECNATSIGLDGCDLMCCGRGYRTETEEVKERCNCTFHWCCEVKCENCTRTRTVH 308

                ..
gi 17402914 353 TC 354
Cdd:cd19333 309 TC 310
Wnt_Wnt7a cd19349
Wnt domain found in protein Wnt-7a and similar proteins; Wnt-7a acts as a canonical Wnt ligand ...
37-355 1.81e-106

Wnt domain found in protein Wnt-7a and similar proteins; Wnt-7a acts as a canonical Wnt ligand that modulates the synaptic vesicle cycle and synaptic transmission in hippocampal neurons. It also plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381723  Cd Length: 318  Bit Score: 314.68  E-value: 1.81e-106
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914  37 CANLP-LNSRQKELCKRKPYLLPSIREGARLGIQECGSQFRHERWNCmitaaattAPMGASPLFGYELSSGTKETAFIYA 115
Cdd:cd19349   7 CNKIPgLAPRQRAICQSRPDAIIVIGEGAQMGINECQFQFRNGRWNC--------SALGERTVFGKELKVGSREAAFTYA 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914 116 VMAAGLVHSVTRSCSAGNMTECSCDTTLQNGGSASEGWHWGGCSDDVQYGMWFSRKFLDfpigNTTGKENKVLLaMNLHN 195
Cdd:cd19349  79 IIAAGVAHAITAACTQGNLSDCGCDKEKQGQYNQEEGWKWGGCSADIRYGIGFSKVFVD----AREIKQNARTL-MNLHN 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914 196 NEAGRQAVAKLMSVDCRCHGVSGSCAVKTCWKTMSSFEKIGHLLKDKYENSIQISDKTKRKMRRREKDQRKIPIH----- 270
Cdd:cd19349 154 NEAGRKILEENMKLECKCHGVSGSCTTKTCWTTLPKFRELGYILKDKYNEAVHVEPVRASRNKRPTFLKIKKPLSyrkpm 233
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914 271 KDDLLYVNKSPNYCVEDKKLGIPGTQGRECNRTSEGADGCNLLCCGRGYNTHVVRHVERCECKFIWCCYVRCRRCESMTD 350
Cdd:cd19349 234 DTDLVYIEKSPNYCEEDPVTGSVGTQGRMCNKTAQQNNGCDLMCCGRGYNTHQYSRVWQCNCKFHWCCYVKCNTCSERTE 313

                ....*
gi 17402914 351 VHTCK 355
Cdd:cd19349 314 VYTCK 318
wnt_Wnt7b cd19350
Wnt domain found in protein Wnt-7b and similar proteins; Wnt-7b functions in the canonical Wnt ...
37-355 2.07e-104

Wnt domain found in protein Wnt-7b and similar proteins; Wnt-7b functions in the canonical Wnt/beta-catenin signaling pathway in vascular smooth muscle cells. It is required for normal fusion of the chorion and the allantois during placenta development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381724  Cd Length: 318  Bit Score: 309.63  E-value: 2.07e-104
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914  37 CANLP-LNSRQKELCKRKPYLLPSIREGARLGIQECGSQFRHERWNCmitaaattAPMGASPLFGYELSSGTKETAFIYA 115
Cdd:cd19350   7 CNKIPgLAPRQRAICQSRPDAIIVIGEGAQMGINECQYQFRYGRWNC--------SALGERTVFGQELRVGSREAAFTYA 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914 116 VMAAGLVHSVTRSCSAGNMTECSCDTTLQNGGSASEGWHWGGCSDDVQYGMWFSRKFLDfpiGNTTGKENKVLlaMNLHN 195
Cdd:cd19350  79 ITAAGVAHAVTAACSQGNLSNCGCDREKQGYYNQEEGWKWGGCSADIKYGIDFSRKFVD---AREIKKNARRL--MNLHN 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914 196 NEAGRQAVAKLMSVDCRCHGVSGSCAVKTCWKTMSSFEKIGHLLKDKYENSIQISDKTKRKMR-----RREKDQRKIPIH 270
Cdd:cd19350 154 NEAGRKVLEERMKLECKCHGVSGSCTTKTCWTTLPKFREIGYVLKEKYNAAVQVEVVRASRLRqptflKIKKRRSYQKPM 233
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914 271 KDDLLYVNKSPNYCVEDKKLGIPGTQGRECNRTSEGADGCNLLCCGRGYNTHVVRHVERCECKFIWCCYVRCRRCESMTD 350
Cdd:cd19350 234 ETDLVYIERSPNYCEEDAATGSVGTQGRLCNRTSPHTDGCDLMCCGRGYNTHQYTKVWQCNCKFHWCCFVKCNTCSERTE 313

                ....*
gi 17402914 351 VHTCK 355
Cdd:cd19350 314 VFTCK 318
Wnt_Wnt2 cd19345
Wnt domain found in protein Wnt-2 and similar proteins; Wnt-2, also called Int-1-like protein ...
37-355 2.34e-100

Wnt domain found in protein Wnt-2 and similar proteins; Wnt-2, also called Int-1-like protein 1 (INT1L1), or Int-1-related protein (IRP), functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. It plays an important role in embryonic lung development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381719  Cd Length: 314  Bit Score: 299.16  E-value: 2.34e-100
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914  37 CANLP-LNSRQKELCKRKPYLLPSIREGARLGIQECGSQFRHERWNCMITAAATTapmgaspLFGYELSSGTKETAFIYA 115
Cdd:cd19345   6 CDNIPgLVSRQRQLCHRHPEVMQAIGSGVKEWIAECQHQFRNHRWNCNTLDRDHS-------LFGRLLLRSSRESAFVYA 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914 116 VMAAGLVHSVTRSCSAGNMTECSCDTTLQNGGSASEG-WHWGGCSDDVQYGMWFSRKFLDfpIGNTTGKENKVLlaMNLH 194
Cdd:cd19345  79 ISSAGVVFAITRACSQGELKSCSCDPKKKGSSKDSKGsFDWGGCSDNIDYGIRFARAFVD--AKERKGKDARAL--MNLH 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914 195 NNEAGRQAVAKLMSVDCRCHGVSGSCAVKTCWKTMSSFEKIGHLLKDKYENSIQISDKTKRKMRRREKDQRKIPIhKDDL 274
Cdd:cd19345 155 NNRAGRKAVKRFMTLECKCHGVSGSCTVRTCWLAMADFRKTGDYLRKKYNGAIQVVMNQDGTGFTVANKHFKKPT-KNDL 233
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914 275 LYVNKSPNYCVEDKKLGIPGTQGRECNRTSEGADGCNLLCCGRGYNTHVVRHVERCECKFIWCCYVRCRRCESMTDVHTC 354
Cdd:cd19345 234 VYFENSPDYCVRDRDAGSLGTAGRVCNRTSRGMDGCEVMCCGRGYDTSRVGRMTKCECKFHWCCAVRCKDCHQQVDVHTC 313

                .
gi 17402914 355 K 355
Cdd:cd19345 314 K 314
Wnt_Wnt2b cd19346
Wnt domain found in protein Wnt-2b and similar proteins; Wnt-2b, also called protein Wnt-13, ...
37-355 2.85e-99

Wnt domain found in protein Wnt-2b and similar proteins; Wnt-2b, also called protein Wnt-13, functions in the canonical Wnt/beta-catenin signaling pathway. It plays a redundant role in embryonic lung development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381720  Cd Length: 314  Bit Score: 296.45  E-value: 2.85e-99
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914  37 CANLP-LNSRQKELCKRKPYLLPSIREGARLGIQECGSQFRHERWNCMITAAATTapmgaspLFGYELSSGTKETAFIYA 115
Cdd:cd19346   6 CDNIPgLVNKQRQLCQRHPDIMQSIGEGAKEWIRECQHQFRHHRWNCSTLDRDHT-------VFGRVMLRSSREAAFVYA 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914 116 VMAAGLVHSVTRSCSAGNMTECSCDTTLQNGGSASEG-WHWGGCSDDVQYGMWFSRKFLDfpignttGKENKVLLA---M 191
Cdd:cd19346  79 ISSAGVVYAITRACSQGELKSCSCDPHKRGRSHDERGeFDWGGCSDNINYGIKFAKAFVD-------AKEKKEKDAralM 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914 192 NLHNNEAGRQAVAKLMSVDCRCHGVSGSCAVKTCWKTMSSFEKIGHLLKDKYENSIQISdKTKRKMRRREKDQRKIPIHK 271
Cdd:cd19346 152 NLHNNRCGRMAVKRFMKLECKCHGVSGSCTLRTCWLAMSDFRKTGDYLRKRYNGAVQVT-MNQDGTGFTVANKNFRKATK 230
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914 272 DDLLYVNKSPNYCVEDKKLGIPGTQGRECNRTSEGADGCNLLCCGRGYNTHVVRHVERCECKFIWCCYVRCRRCESMTDV 351
Cdd:cd19346 231 TDLVYFENSPDYCVMDKSAGSLGTAGRVCNKSSRGTDGCEVMCCGRGYDTTRVTRVTKCECKFHWCCAVRCKECEETVDV 310

                ....
gi 17402914 352 HTCK 355
Cdd:cd19346 311 HTCK 314
Wnt_Wnt5b cd19348
Wnt domain found in protein Wnt-5b and similar proteins; Wnt-5b is a secreted growth factor ...
37-355 8.44e-96

Wnt domain found in protein Wnt-5b and similar proteins; Wnt-5b is a secreted growth factor that belongs to the noncanonical members of the Wingless-related MMTV-integration family. Its overexpression is associated with cancer aggressiveness. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381722  Cd Length: 312  Bit Score: 287.26  E-value: 8.44e-96
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914  37 CANLP-LNSRQKELCKRKPYLLPSIREGARLGIQECGSQFRHERWNCmitaaattAPMGASPLFGYELSSGTKETAFIYA 115
Cdd:cd19348   1 CSQLTgLSPGQRKLCQLYQDHMVYIGEGAKTGIKECQYQFRQRRWNC--------STVDNTSVFGRVMQIGSRETAFTYA 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914 116 VMAAGLVHSVTRSCSAGNMTECSCDTTLQNGGSASEgWHWGGCSDDVQYGMWFSRKFLD-------FPigntTGKENKVL 188
Cdd:cd19348  73 VSAAGVVNAISRACREGELSTCGCSRAARPKDLPRD-WLWGGCGDNVEYGYRFAKEFVDarereknYP----KGSEEHAR 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914 189 LAMNLHNNEAGRQAVAKLMSVDCRCHGVSGSCAVKTCWKTMSSFEKIGHLLKDKYENSIQIsdKTKRKMRRREKDQRKIP 268
Cdd:cd19348 148 TLMNLQNNEAGRRAVYNLADVACKCHGVSGSCSLKTCWLQLADFRKVGDLLKEKYDSAAAM--RINRKGKLELVNSRFNP 225
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914 269 IHKDDLLYVNKSPNYCVEDKKLGIPGTQGRECNRTSEGADGCNLLCCGRGYNTHVVRHVERCECKFIWCCYVRCRRCESM 348
Cdd:cd19348 226 PTAEDLVYIDPSPDYCLRNETTGSLGTQGRLCNKTSEGMDGCELMCCGRGYDQFKTVQVERCHCKFHWCCYVKCKKCTEI 305

                ....*..
gi 17402914 349 TDVHTCK 355
Cdd:cd19348 306 VDQFVCK 312
Wnt_Wnt5a cd19347
Wnt domain found in protein Wnt-5a and similar proteins; Wnt-5a is a secreted growth factor ...
37-355 4.54e-95

Wnt domain found in protein Wnt-5a and similar proteins; Wnt-5a is a secreted growth factor that belongs to the noncanonical members of the Wingless-related MMTV-integration family. It can activate or inhibit canonical Wnt signaling, depending on receptor context. Wnt-5a specifically regulates dendritic spine formation in rodent hippocampal neurons, resulting in postsynaptic development that promotes the clustering of the postsynaptic density protein 95 (PSD-95). Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381721  Cd Length: 312  Bit Score: 285.42  E-value: 4.54e-95
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914  37 CANLP-LNSRQKELCKRKPYLLPSIREGARLGIQECGSQFRHERWNCmitaaattAPMGASPLFGYELSSGTKETAFIYA 115
Cdd:cd19347   1 CSQLAgLSQGQKKLCQLYQDHMQYIGEGAKTGIKECQYQFRHRRWNC--------STVDNTSVFGRVMQIGSRETAFTYA 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914 116 VMAAGLVHSVTRSCSAGNMTECSCDTTLQNGgSASEGWHWGGCSDDVQYGMWFSRKFLDFPIGN---TTGKENKVLLAMN 192
Cdd:cd19347  73 ISAAGVVNAVSRACREGELSTCGCSRAARPK-DLPRDWLWGGCGDNLEYGYRFAKEFVDAREREkiyQKGSYESARTLMN 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914 193 LHNNEAGRQAVAKLMSVDCRCHGVSGSCAVKTCWKTMSSFEKIGHLLKDKYENSIQISDKTKRKMRrrEKDQRKIPIHKD 272
Cdd:cd19347 152 LHNNEAGRRTVYNLADVACKCHGVSGSCSLKTCWLQLADFRKVGDALKEKYDSAAAMKLNSRGKLV--QVNSRFNPPTTL 229
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914 273 DLLYVNKSPNYCVEDKKLGIPGTQGRECNRTSEGADGCNLLCCGRGYNTHVVRHVERCECKFIWCCYVRCRRCESMTDVH 352
Cdd:cd19347 230 DLVYIDPSPDYCVRNESTGSLGTQGRLCNKTSEGMDGCELMCCGRGYDQFKTVQTERCHCKFHWCCYVKCKKCTEIVDQF 309

                ...
gi 17402914 353 TCK 355
Cdd:cd19347 310 VCK 312
Wnt_Wnt9 cd19341
Wnt domain found in protein Wnt-9a, Wnt-9b and similar proteins; The family includes Wnt-9a ...
42-355 1.22e-94

Wnt domain found in protein Wnt-9a, Wnt-9b and similar proteins; The family includes Wnt-9a and Wnt-9b, both of which function in the canonical Wnt/beta-catenin signaling pathway. Wnt-9a, also called protein Wnt-14, is required for normal timing of IHH expression during embryonic bone development, normal chondrocyte maturation and for normal bone mineralization during embryonic bone development. Wnt-9a plays a redundant role in maintaining joint integrity. It is a conserved regulator of hematopoietic stem and progenitor cell development. Wnt-9b, also called protein Wnt-14b, or protein Wnt-15, plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381715  Cd Length: 299  Bit Score: 283.79  E-value: 1.22e-94
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914  42 LNSRQKELCKRKPYLLPSIREGARLGIQECGSQFRHERWNCMItaaattapmGASPLFgyELSSGTKETAFIYAVMAAGL 121
Cdd:cd19341   1 LSRRQRRMCRRDPGLAETLLEAIRLSVLECQEQFRYERWNCSL---------GKYRIN--LLKKGYKETAFLYAISSAGL 69
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914 122 VHSVTRSCSAGNMTECSCDTTlQNGGSASEGWHWGGCSDDVQYGMWFSRKFLDFpigntTGKENKVLLA-MNLHNNEAGR 200
Cdd:cd19341  70 THSVARACSSGRLDRCTCDES-FSLEENRQTWLWGGCGDNIKYGKKFTRRFLQL-----KKKSGKDLRAeIDRHNSEVGI 143
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914 201 QAVAKLMSVDCRCHGVSGSCAVKTCWKTMSSFEKIGHLLKDKYENSIQIS-------DKTKRKMRRREKDQRKIPIHKDD 273
Cdd:cd19341 144 RVVREGVKKTCKCHGVSGSCTVKTCWKQLAPFNEIGKILKRKYEKAVKVVsennaatGGSQLRKGKSGSVKKKSRPRRKD 223
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914 274 LLYVNKSPNYCVEDKKLgiPGTQGRECNRTsegaDGCNLLCCGRGYNTHVVRHVERCECKFIWCCYVRCRRCESMTDVHT 353
Cdd:cd19341 224 LVYLEKSPSFCRSTRYS--PGTKGRRCLKG----DNCDTLCCGRGYNTQSEVVVKPCKCRVVWCCQVECKTCTEREEIYT 297

                ..
gi 17402914 354 CK 355
Cdd:cd19341 298 CK 299
Wnt_Wnt8 cd19340
Wnt domain found in protein Wnt-8a, Wnt-8b and similar proteins; The family includes Wnt-8a ...
59-354 2.50e-91

Wnt domain found in protein Wnt-8a, Wnt-8b and similar proteins; The family includes Wnt-8a and Wnt-8b. Wnt-8a, also called protein Wnt-8d, plays a role in embryonic patterning. Wnt-8b may play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus. It acts as a suppressor of early eye and retinal progenitor formation. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381714  Cd Length: 301  Bit Score: 275.33  E-value: 2.50e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914  59 SIREGARLGIQECGSQFRHERWNCMITAAATTApmgasplfgyELSSGTKETAFIYAVMAAGLVHSVTRSCSAGNMTECS 138
Cdd:cd19340  12 SVAAGAQLAMEECQYQFKWDRWNCPESAFFSQK----------NNPSATRETAFVHAISSAGVMYTLTRNCSLGHFEGCG 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914 139 CDTTLqNGGSASEGWHWGGCSDDVQYGMWFSRKFLDfpiGNTTGKEnkVLLAMNLHNNEAGRQAVAKLMSVDCRCHGVSG 218
Cdd:cd19340  82 CDDSK-KGSKGGEGWTWGGCSDNVKFGERVSKKFLD---SLETGQD--AQALMNLHNNRAGRKAVRKTMKKTCKCHGVSG 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914 219 SCAVKTCWKTMSSFEKIGHLLKDKYENSIQI--SDKTKRKMRRREKDQRkIPIHKDDLLYVNKSPNYCVEDKKLGIPGTQ 296
Cdd:cd19340 156 SCSTQTCWMQLAPFREIGTDLKRKYDRAVRVdyENGGLRETNGSRAIKL-LNIKKNDLVYLEKSPNYCRANVTLGWPGTL 234
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17402914 297 GRECNRTSEGADG------CNLLC--CGRGYNTHVVRHVERCECKFIWCCYVRCRRCESMTDVHTC 354
Cdd:cd19340 235 GRQCSRDKKESVSrwerksCRRLCraCGLKVRKKVVEVTSSCNCKFHWCCEVKCETCVELVIEYTC 300
Wnt_Wnt9b cd19354
Wnt domain found in protein Wnt-9b and similar proteins; Wnt-9b, also called protein Wnt-14b ...
42-355 7.57e-84

Wnt domain found in protein Wnt-9b and similar proteins; Wnt-9b, also called protein Wnt-14b or Wnt-15, functions in the canonical Wnt/beta-catenin signaling pathway. It plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381728  Cd Length: 297  Bit Score: 256.36  E-value: 7.57e-84
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914  42 LNSRQKELCKRKPYLLPSIREGARLGIQECGSQFRHERWNCMITAAATTapmgasplfgyeLSSGTKETAFIYAVMAAGL 121
Cdd:cd19354   1 LSRRQKRLCRREPGLAETLRDAVRLGLLECQFQFRSERWNCSLEGRGSL------------LKRGFKETAFLYAVSSAAL 68
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914 122 VHSVTRSCSAGNMTECSCDTT--LQNggsaSEGWHWGGCSDDVQYGMWFSRKFLDfpigntTGKENKVLLA-MNLHNNEA 198
Cdd:cd19354  69 THSLAKACSSGRMERCTCDDSpgLEN----REAWQWGVCGDNLKYSTKFLKNFLG------QKKGSKDLRArVDAHNTNV 138
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914 199 GRQAVAKLMSVDCRCHGVSGSCAVKTCWKTMSSFEKIGHLLKDKYENSIQISDKTKRKMRRREKDQRKIPIHK------- 271
Cdd:cd19354 139 GIKAVKSGLKTTCKCHGVSGSCAVRTCWKQLSPFHETGRLLKLKYENAVKVHSVTNDATGETELWSPERHGHTlkghspr 218
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914 272 -DDLLYVNKSPNYCVEDKKlgIPGTQGRECNRTSEgadgCNLLCCGRGYNTHVVRHVERCECKFIWCCYVRCRRCESMTD 350
Cdd:cd19354 219 sTDLVYLEDSPSFCRPSKY--SPGTAGRTCSRETN----CDSLCCGRGYNTQSRLVTFSCHCQVQWCCYVECQQCVQEEE 292

                ....*
gi 17402914 351 VHTCK 355
Cdd:cd19354 293 VYTCK 297
Wnt_Wnt10a cd19355
Wnt domain found in protein Wnt-10a and similar proteins; Wnt-10a plays a role in normal ...
37-355 1.13e-80

Wnt domain found in protein Wnt-10a and similar proteins; Wnt-10a plays a role in normal ectoderm development. It is required for normal postnatal development and maintenance of tongue papillae and sweat ducts, as well as normal hair follicle function. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381729  Cd Length: 302  Bit Score: 248.36  E-value: 1.13e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914  37 CANLP-LNSRQKELCKRKPYLLPSIREGARLGIQECGSQFRHERWNCMITAAATTAPMgASPLFgyelSSGTKETAFIYA 115
Cdd:cd19355   4 CLTLPgLTRRQLEVCMRHPDVTASAIQGIQIAIHECQHQFRDHRWNCSSLETRNKIPY-ESVVF----SRGFRESAFAYA 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914 116 VMAAGLVHSVTRSCSAGNMTECSCDttlqnggsasegWHWGGCSDDVQYGMWFSRKFLDfpignTTGKENKVLLAMNLHN 195
Cdd:cd19355  79 IAAAGVVHAVSNACAMGKLKACGCD------------WEWGGCSPDVEYGERFSKDFLD-----SRETYRDIHARMRLHN 141
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914 196 NEAGRQAVAKLMSVDCRCHGVSGSCAVKTCWKTMSSFEKIGHLLKDKYENSIQI---SDKTKRKMRRREKDQRKIPIHkd 272
Cdd:cd19355 142 NRVGRQVVMDNMRRKCKCHGTSGSCQLKTCWQVTPEFRTVGSLLKDRFYVATLIkphNRNTGQLEPGHAPHRRRASIN-- 219
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914 273 DLLYVNKSPNYCVEDKKLGIPGTQGRECNRTSEGADGCNLLCCGRGYNTHVVRHVERCECKFIWCCYVRCRRCESMTDVH 352
Cdd:cd19355 220 DLVYFEKSPDFCEREPRLDSAGTQGRICNKTSPGMDNCESLCCGRGHNILRQTRSERCNCKFHWCCYVVCEECRITEWVS 299

                ...
gi 17402914 353 TCK 355
Cdd:cd19355 300 VCK 302
Wnt_Wnt10b cd19356
Wnt domain found in protein Wnt-10b and similar proteins; Wnt-10b, also called protein Wnt-12, ...
37-355 7.62e-76

Wnt domain found in protein Wnt-10b and similar proteins; Wnt-10b, also called protein Wnt-12, specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. It is involved in signaling networks controlling stemness, pluripotency and cell fate decisions. Wnt-10b is unique and plays an important role in differentiation of epithelial cells in the hair follicle. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381730  Cd Length: 299  Bit Score: 235.94  E-value: 7.62e-76
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914  37 CANLP-LNSRQKELCKRKPYLLPSIREGARLGIQECGSQFRHERWNCmitaaATTAPMGASPLFGYELSSGTKETAFIYA 115
Cdd:cd19356   4 CLTLPgLSKRQMGLCVRSPDVTASALQGIQIAIHECQHQLRDQRWNC-----SSLEGGGKLPHDSAILKRGFRESAFSFS 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914 116 VMAAGLVHSVTRSCSAGNMTECSCdttlqnggsaseGWHWGGCSDDVQYGMWFSRKFLDfpignTTGKENKVLLAMNLHN 195
Cdd:cd19356  79 LLAAGVMHSVATACSLGKLRGCGC------------EWEWGGCSHDIEFGEKFSRDFLD-----SRESPRDIQARMRIHN 141
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914 196 NEAGRQAVAKLMSVDCRCHGVSGSCAVKTCWKTMSSFEKIGHLLKDKYENSIQISDKTK------RKMRRREKDQrkipi 269
Cdd:cd19356 142 NRVGRQVVTENMKRKCKCHGTSGSCQFKTCWHVTPEFRLVGALLREKFQRAIFINSHNKnsgvflPRLRPRRLAR----- 216
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914 270 hkdDLLYVNKSPNYCVEDKKLGIPGTQGRECNRTSEGADGCNLLCCGRGYNTHVVRHVERCECKFIWCCYVRCRRCESMT 349
Cdd:cd19356 217 ---ELVYFEKSPDFCERDPAVDSPGTQGRICNKTSPGMDGCGSLCCGRGHNILKQTRSERCHCRFHWCCYVLCEECRVTE 293

                ....*.
gi 17402914 350 DVHTCK 355
Cdd:cd19356 294 WVNVCK 299
Wnt_Wnt9a cd19353
Wnt domain found in protein Wnt-9a and similar proteins; Wnt-9a, also called protein Wnt-14, ...
42-355 1.47e-73

Wnt domain found in protein Wnt-9a and similar proteins; Wnt-9a, also called protein Wnt-14, functions in the canonical Wnt/beta-catenin signaling pathway. It is required for normal timing of IHH expression during embryonic bone development, normal chondrocyte maturation and for normal bone mineralization during embryonic bone development. Wnt-9a plays a redundant role in maintaining joint integrity. It is a conserved regulator of hematopoietic stem and progenitor cell development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381727  Cd Length: 298  Bit Score: 229.92  E-value: 1.47e-73
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914  42 LNSRQKELCKRKPYLLPSIREGARLGIQECGSQFRHERWNCMITAAATTAPmgasplfgyeLSSGTKETAFIYAVMAAGL 121
Cdd:cd19353   1 LERKQRRMCRRDPGVAETLMEAISMSALECQYQFRFERWNCTLEGRYRASL----------LKRGFKETAFLYAISSAGL 70
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914 122 VHSVTRSCSAGNMTECSCDTT--LQNggsaSEGWHWGGCSDDVQYGMWFSRKFLdfpiGNTTGKENKVllAMNLHNNEAG 199
Cdd:cd19353  71 THAMAKACSAGRMERCTCDEApdLEN----REAWQWGGCGDNLKYSNKFVKEFL----GRKSSKDLRA--RVDFHNNLVG 140
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914 200 RQAVAKLMSVDCRCHGVSGSCAVKTCWKTMSSFEKIGHLLKDKYENSIQISDKTKRKMRRRE--KDQRKIPIHKD----- 272
Cdd:cd19353 141 IKVIKAGVETTCKCHGVSGSCTVRTCWRQLSPFHEIGKQLKQKYETSLKVGSTTNEATGEGDisPPKKSGAGHSDqiprt 220
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914 273 -DLLYVNKSPNYCVEDKKlgIPGTQGRECNRTSEgadgCNLLCCGRGYNTHVVRHVERCECKFIWCCYVRCRRCESMTDV 351
Cdd:cd19353 221 tDLVYIDDSPSFCLMSRF--SPGTSGRRCYKDKN----CESICCGRGHNTQSRVVTRPCQCQVRWCCYVECKQCTQREEV 294

                ....
gi 17402914 352 HTCK 355
Cdd:cd19353 295 YTCK 298
Wnt_Wnt8a cd19351
Wnt domain found in protein Wnt-8a and similar proteins; Wnt-8a, also called protein Wnt-8d, ...
59-354 8.09e-73

Wnt domain found in protein Wnt-8a and similar proteins; Wnt-8a, also called protein Wnt-8d, plays a role in embryonic patterning. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381725  Cd Length: 307  Bit Score: 228.25  E-value: 8.09e-73
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914  59 SIREGARLGIQECGSQFRHERWNCMITAAATTAPMGasplfgyeLSSGTKETAFIYAVMAAGLVHSVTRSCSAGNMTECS 138
Cdd:cd19351  12 SVAAGAQSGIEECKHQFAWERWNCPESALQLSTHNG--------LRSATRETSFVHAISSAGVMYTLTRNCSLGDFENCG 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914 139 CDTTlQNGGSASEGWHWGGCSDDVQYGMWFSRKFLDfpiGNTTGKENKVLlaMNLHNNEAGRQAVAKLMSVDCRCHGVSG 218
Cdd:cd19351  84 CDDS-RNGRTGGRGWIWGGCSDNVEFGERISKQFVD---ALETGQDARAL--MNLHNNEAGRLAVKATMKRTCKCHGVSG 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914 219 SCAVKTCWKTMSSFEKIGHLLKDKYENSIQIsDKTKRKMRR-REKDQRKI------PIHKDDLLYVNKSPNYCVEDKKLG 291
Cdd:cd19351 158 SCSIQTCWLQLADFREIGNYLKVKHDQALKL-EMDKRRMRAgNSADNRGAiaeafgSVAETELIYLEDSPDYCTKNASLG 236
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914 292 IPGTQGRECNRTSEGAD-----GCNLLC--CGRGYNTHVVRHVERCECKFIWCCYVRCRRCESMTDVHTC 354
Cdd:cd19351 237 LQGTEGRECLQSGKNLSqwerrSCRRLCteCGLRVEERRTEVVSSCNCKFHWCCTVKCEQCRQVVTKHYC 306
Wnt_Wnt8b cd19352
Wnt domain found in protein Wnt-8b and similar proteins; Wnt-8b may play an important role in ...
53-354 1.44e-67

Wnt domain found in protein Wnt-8b and similar proteins; Wnt-8b may play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus. It acts as a suppressor of early eye and retinal progenitor formation. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381726  Cd Length: 305  Bit Score: 214.89  E-value: 1.44e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914  53 KPYLL--PSIREGARLGIQECGSQFRHERWNCMITAAATTAPMGasplfgyeLSSGTKETAFIYAVMAAGLVHSVTRSCS 130
Cdd:cd19352   5 KAYLIysSSVAAGAQSGIEECKYQFAWDRWNCPERALQLSSHSG--------LRSANRETAFVHAISSAGVMYTLTRNCS 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914 131 AGNMTECSCDTTlQNGGSASEGWHWGGCSDDVQYGMWFSRKFLDfpiGNTTGKENKVllAMNLHNNEAGRQAVAKLMSVD 210
Cdd:cd19352  77 LGDFDNCGCDDS-RNGQLGGQGWLWGGCSDNVGFGEAISKQFVD---ALETGQDARA--AMNLHNNEAGRKAVKGTMKRT 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402914 211 CRCHGVSGSCAVKTCWKTMSSFEKIGHLLKDKYENSIQIS---DKTKRKMRRREKDQRKIPIHKDDLLYVNKSPNYCVED 287
Cdd:cd19352 151 CKCHGVSGSCTTQTCWLQLPEFREVGNYLKEKYHRALKVDllqGAGNSAASRGAIAETFRSISKKELVHLEDSPDYCLEN 230
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17402914 288 KKLGIPGTQGRECNRTSEGAD-----GCNLLC--CGRGYNTHVVRHVERCECKFIWCCYVRCRRCESMTDVHTC 354
Cdd:cd19352 231 KTLGLLGTEGRECLKRGKALSkwekrSCRRLCgdCGLAVEERRAEMVSSCNCKFHWCCAVKCEQCRKTVTKYFC 304
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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