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Conserved domains on  [gi|7705831|ref|NP_057199|]
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ankyrin repeat and SOCS box protein 3 isoform a [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
16-269 4.73e-46

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 162.82  E-value: 4.73e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831   16 LAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADsseNYIKMKTFEGFCALHLAASQGHWKIV 95
Cdd:COG0666  27 AAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAG---ADINAKDDGGNTLLHAAARNGDLEIV 103

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831   96 QILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMcGWNSLHQASFQENAEIIKLLLRKGANKECQ 175
Cdd:COG0666 104 KLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDND-GNTPLHLAAANGNLEIVKLLLEAGADVNAR 182

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831  176 DDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSwqLPIHAAA 255
Cdd:COG0666 183 DNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGL--TALLLAA 260

                       250
                ....*....|....
gi 7705831  256 QMGHTKILDLLIPL 269
Cdd:COG0666 261 AAGAALIVKLLLLA 274
SOCS_ASB3 cd03722
SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a ...
 457-507 6.50e-26

SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ABS3 has been shown to be negative regulator of TNF-R2-mediated cellular responses to TNF-alpha by direct targeting of tumor necrosis factor receptor II (TNF-R2) for ubiquitination and proteasome-mediated degradation. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


:

Pssm-ID: 239692  Cd Length: 51  Bit Score: 99.87  E-value: 6.50e-26
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 7705831  457 ATVPSLTHLCRLEIRSSLKSERLRSDSYISQLPLPRSLHNYLLYEDVLRMY 507
Cdd:cd03722   1 ASVPSLTHLCRLEIRSSLKSERLRSDSFICQLPLPRSLQDYLLYSDVLRMY 51
ANKYR super family cl34000
Ankyrin repeat [Signal transduction mechanisms];
192-368 1.43e-05

Ankyrin repeat [Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG0666:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 46.87  E-value: 1.43e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831  192 LESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLycNEDSWQLPIHAAAQMGHTKILDLLIPLTN 271
Cdd:COG0666   1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALAL--ADALGALLLLAAALAGDLLVALLLLAAGA 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831  272 RACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQAclVFGFSSPVCMAFQKDCEffgIVNILLKYGAQINE----- 346
Cdd:COG0666  79 DINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARD--KDGETPLHLAAYNGNLE---IVKLLLEAGADVNAqdndg 153

                       170       180
                ....*....|....*....|....*
gi 7705831  347 ---LHLAYCLKYEKfsIFRYFLRKG 368
Cdd:COG0666 154 ntpLHLAAANGNLE--IVKLLLEAG 176
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
16-269 4.73e-46

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 162.82  E-value: 4.73e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831   16 LAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADsseNYIKMKTFEGFCALHLAASQGHWKIV 95
Cdd:COG0666  27 AAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAG---ADINAKDDGGNTLLHAAARNGDLEIV 103

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831   96 QILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMcGWNSLHQASFQENAEIIKLLLRKGANKECQ 175
Cdd:COG0666 104 KLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDND-GNTPLHLAAANGNLEIVKLLLEAGADVNAR 182

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831  176 DDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSwqLPIHAAA 255
Cdd:COG0666 183 DNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGL--TALLLAA 260

                       250
                ....*....|....
gi 7705831  256 QMGHTKILDLLIPL 269
Cdd:COG0666 261 AAGAALIVKLLLLA 274
SOCS_ASB3 cd03722
SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a ...
 457-507 6.50e-26

SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ABS3 has been shown to be negative regulator of TNF-R2-mediated cellular responses to TNF-alpha by direct targeting of tumor necrosis factor receptor II (TNF-R2) for ubiquitination and proteasome-mediated degradation. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239692  Cd Length: 51  Bit Score: 99.87  E-value: 6.50e-26
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 7705831  457 ATVPSLTHLCRLEIRSSLKSERLRSDSYISQLPLPRSLHNYLLYEDVLRMY 507
Cdd:cd03722   1 ASVPSLTHLCRLEIRSSLKSERLRSDSFICQLPLPRSLQDYLLYSDVLRMY 51
PHA03095 PHA03095
ankyrin-like protein; Provisional
 3-241 1.87e-22

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 100.10  E-value: 1.87e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831     3 FTEAYADTCSTVGLAAREGNVK-VLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVE-CLQMLI--NADssenyIKMKTFE 78
Cdd:PHA03095  42 FRGEYGKTPLHLYLHYSSEKVKdIVRLLLEAGADVNAPERCGFTPLHLYLYNATTLdVIKLLIkaGAD-----VNAKDKV 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831    79 GFCALH--LAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDV--LRLLLQHGANVNGShSMCGWNSLHQ-- 152
Cdd:PHA03095 117 GRTPLHvyLSGFNINPKVIRLLLRKGADVNALDLYGMTPLAVLLKSRNANVelLRLLIDAGADVYAV-DDRFRSLLHHhl 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831   153 ASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSI--LISSGANVNCQALDKATPLFIAAQEGHTKCVEL 230
Cdd:PHA03095 196 QSFKPRARIVRELIRAGCDPAATDMLGNTPLHSMATGSSCKRSLVlpLLIAGISINARNRYGQTPLHYAAVFNNPRACRR 275

                        250
                 ....*....|.
gi 7705831   231 LLSSGADPDLY 241
Cdd:PHA03095 276 LIALGADINAV 286
Ank_2 pfam12796
Ankyrin repeats (3 copies);
83-176 1.00e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 86.71  E-value: 1.00e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831     83 LHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHganVNGSHSMCGWNSLHQASFQENAEII 162
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH---ADVNLKDNGRTALHYAARSGHLEIV 77

                          90
                  ....*....|....
gi 7705831    163 KLLLRKGANKECQD 176
Cdd:pfam12796  78 KLLLEKGADINVKD 91
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 42-234 4.38e-15

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 78.13  E-value: 4.38e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831   42 RGW-MPIHEAAYHNSVECLQMLINADSSENYIKMKTFEgfCALHLAASQGHWKIVQILLEAgaDPNATTLEET------- 113
Cdd:cd22192  15 RISeSPLLLAAKENDVQAIKKLLKCPSCDLFQRGALGE--TALHVAALYDNLEAAVVLMEA--APELVNEPMTsdlyqge 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831  114 TPLFLAVENGQIDVLRLLLQHGANVN-----------GSHSMC--GWNSLHQASFQENAEIIKLLLRKGANKECQDDFGI 180
Cdd:cd22192  91 TALHIAVVNQNLNLVRELIARGADVVspratgtffrpGPKNLIyyGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGN 170

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 7705831  181 TPLFV-AAQYGKL---ESLSILISSGANVNCQALDKA------TPLFIAAQEGHTKCVELLLSS 234
Cdd:cd22192 171 TVLHIlVLQPNKTfacQMYDLILSYDKEDDLQPLDLVpnnqglTPFKLAAKEGNIVMFQHLVQK 234
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 458-499 4.74e-11

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 57.56  E-value: 4.74e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 7705831    458 TVPSLTHLCRLEIRSSLKSERLrsdSYISQLPLPRSLHNYLL 499
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRRL---GAIDKLPLPPLLKDYLL 39
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 460-501 7.61e-09

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 51.26  E-value: 7.61e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 7705831     460 PSLTHLCRLEIRSSLKSerlrsdsyISQLPLPRSLHNYLLYE 501
Cdd:smart00969   1 RSLQHLCRLAIRRSLGG--------IDKLPLPPRLKDYLLYY 34
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 114-139 1.13e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 42.19  E-value: 1.13e-05
                           10        20
                   ....*....|....*....|....*.
gi 7705831     114 TPLFLAVENGQIDVLRLLLQHGANVN 139
Cdd:smart00248   4 TPLHLAAENGNLEVVKLLLDKGADIN 29
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
192-368 1.43e-05

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 46.87  E-value: 1.43e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831  192 LESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLycNEDSWQLPIHAAAQMGHTKILDLLIPLTN 271
Cdd:COG0666   1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALAL--ADALGALLLLAAALAGDLLVALLLLAAGA 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831  272 RACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQAclVFGFSSPVCMAFQKDCEffgIVNILLKYGAQINE----- 346
Cdd:COG0666  79 DINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARD--KDGETPLHLAAYNGNLE---IVKLLLEAGADVNAqdndg 153

                       170       180
                ....*....|....*....|....*
gi 7705831  347 ---LHLAYCLKYEKfsIFRYFLRKG 368
Cdd:COG0666 154 ntpLHLAAANGNLE--IVKLLLEAG 176
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 16-151 2.73e-05

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 47.00  E-value: 2.73e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831     16 LAAREGNVKVLRKLLK-KGRSVDVADNRgwmpIHEAA--YHNSVE-CLQMLINADSSE------NYIKMKTF-EGFCALH 84
Cdd:TIGR00870  58 VAAIENENLELTELLLnLSCRGAVGDTL----LHAISleYVDAVEaILLHLLAAFRKSgplelaNDQYTSEFtPGITALH 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831     85 LAASQGHWKIVQILLEAGADPNAT-------TLEETT-------PLFLAVENGQIDVLRLLLQHGANVNGSHSMcGWNSL 150
Cdd:TIGR00870 134 LAAHRQNYEIVKLLLERGASVPARacgdffvKSQGVDsfyhgesPLNAAACLGSPSIVALLSEDPADILTADSL-GNTLL 212


                  .
gi 7705831    151 H 151
Cdd:TIGR00870 213 H 213
Ank_2 pfam12796
Ankyrin repeats (3 copies);
251-345 4.84e-05

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 42.03  E-value: 4.84e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831    251 IHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNgyspdAQACLVFGFSSPVCMAFQKDCef 330
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-----ADVNLKDNGRTALHYAARSGH-- 73

                          90
                  ....*....|....*
gi 7705831    331 FGIVNILLKYGAQIN 345
Cdd:pfam12796  74 LEIVKLLLEKGADIN 88
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
16-269 4.73e-46

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 162.82  E-value: 4.73e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831   16 LAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADsseNYIKMKTFEGFCALHLAASQGHWKIV 95
Cdd:COG0666  27 AAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAG---ADINAKDDGGNTLLHAAARNGDLEIV 103

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831   96 QILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMcGWNSLHQASFQENAEIIKLLLRKGANKECQ 175
Cdd:COG0666 104 KLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDND-GNTPLHLAAANGNLEIVKLLLEAGADVNAR 182

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831  176 DDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSwqLPIHAAA 255
Cdd:COG0666 183 DNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGL--TALLLAA 260

                       250
                ....*....|....
gi 7705831  256 QMGHTKILDLLIPL 269
Cdd:COG0666 261 AAGAALIVKLLLLA 274
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
16-245 5.47e-46

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 162.43  E-value: 5.47e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831   16 LAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYikmKTFEGFCALHLAASQGHWKIV 95
Cdd:COG0666  60 AAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNA---RDKDGETPLHLAAYNGNLEIV 136

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831   96 QILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMcGWNSLHQASFQENAEIIKLLLRKGANKECQ 175
Cdd:COG0666 137 KLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDND-GETPLHLAAENGHLEIVKLLLEAGADVNAK 215

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831  176 DDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNED 245
Cdd:COG0666 216 DNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDL 285
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
26-303 1.15e-45

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 161.66  E-value: 1.15e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831   26 LRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADP 105
Cdd:COG0666   1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831  106 NATTLEETTPLFLAVENGQIDVLRLLLQHGANVNgSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFV 185
Cdd:COG0666  81 NAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVN-ARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHL 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831  186 AAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWqlPIHAAAQMGHTKILDL 265
Cdd:COG0666 160 AAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKT--ALDLAAENGNLEIVKL 237

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 7705831  266 LIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNG 303
Cdd:COG0666 238 LLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLAL 275
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
16-216 6.05e-40

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 146.25  E-value: 6.05e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831   16 LAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENyikMKTFEGFCALHLAASQGHWKIV 95
Cdd:COG0666  93 AAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVN---AQDNDGNTPLHLAAANGNLEIV 169

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831   96 QILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNgSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQ 175
Cdd:COG0666 170 KLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVN-AKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAK 248

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 7705831  176 DDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPL 216
Cdd:COG0666 249 DKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
SOCS_ASB3 cd03722
SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a ...
 457-507 6.50e-26

SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ABS3 has been shown to be negative regulator of TNF-R2-mediated cellular responses to TNF-alpha by direct targeting of tumor necrosis factor receptor II (TNF-R2) for ubiquitination and proteasome-mediated degradation. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239692  Cd Length: 51  Bit Score: 99.87  E-value: 6.50e-26
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 7705831  457 ATVPSLTHLCRLEIRSSLKSERLRSDSYISQLPLPRSLHNYLLYEDVLRMY 507
Cdd:cd03722   1 ASVPSLTHLCRLEIRSSLKSERLRSDSFICQLPLPRSLQDYLLYSDVLRMY 51
PHA03095 PHA03095
ankyrin-like protein; Provisional
 3-241 1.87e-22

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 100.10  E-value: 1.87e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831     3 FTEAYADTCSTVGLAAREGNVK-VLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVE-CLQMLI--NADssenyIKMKTFE 78
Cdd:PHA03095  42 FRGEYGKTPLHLYLHYSSEKVKdIVRLLLEAGADVNAPERCGFTPLHLYLYNATTLdVIKLLIkaGAD-----VNAKDKV 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831    79 GFCALH--LAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDV--LRLLLQHGANVNGShSMCGWNSLHQ-- 152
Cdd:PHA03095 117 GRTPLHvyLSGFNINPKVIRLLLRKGADVNALDLYGMTPLAVLLKSRNANVelLRLLIDAGADVYAV-DDRFRSLLHHhl 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831   153 ASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSI--LISSGANVNCQALDKATPLFIAAQEGHTKCVEL 230
Cdd:PHA03095 196 QSFKPRARIVRELIRAGCDPAATDMLGNTPLHSMATGSSCKRSLVlpLLIAGISINARNRYGQTPLHYAAVFNNPRACRR 275

                        250
                 ....*....|.
gi 7705831   231 LLSSGADPDLY 241
Cdd:PHA03095 276 LIALGADINAV 286
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
94-345 2.13e-22

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 97.33  E-value: 2.13e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831   94 IVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKE 173
Cdd:COG0666   2 LLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADIN 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831  174 CQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDlycnedswqlpihA 253
Cdd:COG0666  82 AKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVN-------------A 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831  254 AAQMGHTkildllipltnracdtglnkvsPVYSAVFGGHEDCLEILLRNGYSPDAQAClvfGFSSPVCMAFQKDCEffGI 333
Cdd:COG0666 149 QDNDGNT----------------------PLHLAAANGNLEIVKLLLEAGADVNARDN---DGETPLHLAAENGHL--EI 201

                       250
                ....*....|..
gi 7705831  334 VNILLKYGAQIN 345
Cdd:COG0666 202 VKLLLEAGADVN 213
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 22-237 1.86e-21

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 96.66  E-value: 1.86e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831    22 NVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINadsSENYIKMKTFEGFCALHLAASQGH-----WKIVQ 96
Cdd:PHA03100  14 KVKNIKYIIMEDDLNDYSYKKPVLPLYLAKEARNIDVVKILLD---NGADINSSTKNNSTPLHYLSNIKYnltdvKEIVK 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831    97 ILLEAGADPNATTLEETTPLFLAVEN--GQIDVLRLLLQHGANVNgSHSMCGWNSLHQA--SFQENAEIIKLLLRKGA-- 170
Cdd:PHA03100  91 LLLEYGANVNAPDNNGITPLLYAISKksNSYSIVEYLLDNGANVN-IKNSDGENLLHLYleSNKIDLKILKLLIDKGVdi 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831   171 NKECQ--------------DDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGA 236
Cdd:PHA03100 170 NAKNRvnyllsygvpinikDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGP 249


                 .
gi 7705831   237 D 237
Cdd:PHA03100 250 S 250
Ank_2 pfam12796
Ankyrin repeats (3 copies);
83-176 1.00e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 86.71  E-value: 1.00e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831     83 LHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHganVNGSHSMCGWNSLHQASFQENAEII 162
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH---ADVNLKDNGRTALHYAARSGHLEIV 77

                          90
                  ....*....|....
gi 7705831    163 KLLLRKGANKECQD 176
Cdd:pfam12796  78 KLLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
150-240 1.56e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 85.94  E-value: 1.56e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831    150 LHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSgANVNCQaLDKATPLFIAAQEGHTKCVE 229
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLK-DNGRTALHYAARSGHLEIVK 78

                          90
                  ....*....|.
gi 7705831    230 LLLSSGADPDL 240
Cdd:pfam12796  79 LLLEKGADINV 89
PHA03095 PHA03095
ankyrin-like protein; Provisional
 23-308 9.46e-20

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 92.01  E-value: 9.46e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831    23 VKVLRKLLKKGRSVDVADNRGWMPIHeaAYhnsveclqmlinadssenyikMKTFEGFCAlhlaasqghwKIVQILLEAG 102
Cdd:PHA03095  27 VEEVRRLLAAGADVNFRGEYGKTPLH--LY---------------------LHYSSEKVK----------DIVRLLLEAG 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831   103 ADPNATTLEETTPLFLAVENGQ-IDVLRLLLQHGANVNGSHSmCGWNSLHQ--ASFQENAEIIKLLLRKGANKECQDDFG 179
Cdd:PHA03095  74 ADVNAPERCGFTPLHLYLYNATtLDVIKLLIKAGADVNAKDK-VGRTPLHVylSGFNINPKVIRLLLRKGADVNALDLYG 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831   180 ITPLFVaaqYGK-----LESLSILISSGANVNCQALDKATPLFIAAQEGHT--KCVELLLSSGADPDlyCNEDSWQLPIH 252
Cdd:PHA03095 153 MTPLAV---LLKsrnanVELLRLLIDAGADVYAVDDRFRSLLHHHLQSFKPraRIVRELIRAGCDPA--ATDMLGNTPLH 227

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 7705831   253 AAAQMG---HTKILDLL-----IPLTNRACDTGLNkvspvYSAVFGGHEDCLEiLLRNGYSPDA 308
Cdd:PHA03095 228 SMATGSsckRSLVLPLLiagisINARNRYGQTPLH-----YAAVFNNPRACRR-LIALGADINA 285
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 21-240 9.00e-19

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 88.51  E-value: 9.00e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831    21 GNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYiKMKTFEGfcALHLAASQGHWKIVQILLE 100
Cdd:PHA02875  13 GELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDV-KYPDIES--ELHDAVEEGDVKAVEELLD 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831   101 AGADPNATTLEE-TTPLFLAVENGQIDVLRLLLQHGANVNGShSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFG 179
Cdd:PHA02875  90 LGKFADDVFYKDgMTPLHLATILKKLDIMKLLIARGADPDIP-NTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCG 168

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 7705831   180 ITPLFVAAQYGKLESLSILISSGANVNCQALDK-ATPLFIAAQEGHTKCVELLLSSGADPDL 240
Cdd:PHA02875 169 CTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGcVAALCYAIENNKIDIVRLFIKRGADCNI 230
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 22-206 1.24e-18

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 88.18  E-value: 1.24e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831    22 NVKVLRKLLKKGRSVD--VADNRGWMPIHEAAYHNS---VECLQMLINadsSENYIKMKTFEGFCALHLAASQ--GHWKI 94
Cdd:PHA03100  47 NIDVVKILLDNGADINssTKNNSTPLHYLSNIKYNLtdvKEIVKLLLE---YGANVNAPDNNGITPLLYAISKksNSYSI 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831    95 VQILLEAGADPNATTLEETTPLFLAVENGQID--VLRLLLQHGANVN-----------GSH----SMCGWNSLHQASFQE 157
Cdd:PHA03100 124 VEYLLDNGANVNIKNSDGENLLHLYLESNKIDlkILKLLIDKGVDINaknrvnyllsyGVPinikDVYGFTPLHYAVYNN 203

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 7705831   158 NAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVN 206
Cdd:PHA03100 204 NPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIK 252
Ank_2 pfam12796
Ankyrin repeats (3 copies);
16-108 1.20e-17

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 77.85  E-value: 1.20e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831     16 LAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENyikmkTFEGFCALHLAASQGHWKIV 95
Cdd:pfam12796   3 LAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNL-----KDNGRTALHYAARSGHLEIV 77

                          90
                  ....*....|...
gi 7705831     96 QILLEAGADPNAT 108
Cdd:pfam12796  78 KLLLEKGADINVK 90
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 113-361 3.69e-17

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 83.56  E-value: 3.69e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831   113 TTPLFLAVENGQIDVLRLLLQHGANVNgSHSMCGWNSLH-----QASFQENAEIIKLLLRKGANKECQDDFGITPLFVAA 187
Cdd:PHA03100  36 VLPLYLAKEARNIDVVKILLDNGADIN-SSTKNNSTPLHylsniKYNLTDVKEIVKLLLEYGANVNAPDNNGITPLLYAI 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831   188 QyGKLESLSI---LISSGANVNCQALDKATPLFIAAQEGH--TKCVELLLSSGADPDLYCNEDSwqlpihaaaqmghtkI 262
Cdd:PHA03100 115 S-KKSNSYSIveyLLDNGANVNIKNSDGENLLHLYLESNKidLKILKLLIDKGVDINAKNRVNY---------------L 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831   263 LDLLIPLTNRacdtGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDaqACLVFGfSSPVCMAFQKDCEFfgIVNILLKYGA 342
Cdd:PHA03100 179 LSYGVPINIK----DVYGFTPLHYAVYNNNPEFVKYLLDLGANPN--LVNKYG-DTPLHIAILNNNKE--IFKLLLNNGP 249

                        250
                 ....*....|....*....
gi 7705831   343 QINelHLAYCLKYEKFSIF 361
Cdd:PHA03100 250 SIK--TIIETLLYFKDKDL 266
Ank_2 pfam12796
Ankyrin repeats (3 copies);
47-139 5.09e-17

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 76.31  E-value: 5.09e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831     47 IHEAAYHNSVECLQMLINADSSENyikMKTFEGFCALHLAASQGHWKIVQILLEaGADPNATTlEETTPLFLAVENGQID 126
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADAN---LQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKD-NGRTALHYAARSGHLE 75

                          90
                  ....*....|...
gi 7705831    127 VLRLLLQHGANVN 139
Cdd:pfam12796  76 IVKLLLEKGADIN 88
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 83-388 1.35e-16

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 82.80  E-value: 1.35e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831    83 LHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSmcgwnSLHQASFQENAEII 162
Cdd:PHA02876 182 IHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSNINKNDL-----SLLKAIRNEDLETS 256

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831   163 KLLLRKGANKECQDDFGITPLFVAAQYGKLESL-SILISSGANVNCQALDKATPLFIAAQEGH-TKCVELLLSSGADPDl 240
Cdd:PHA02876 257 LLLYDAGFSVNSIDDCKNTPLHHASQAPSLSRLvPKLLERGADVNAKNIKGETPLYLMAKNGYdTENIRTLIMLGADVN- 335

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831   241 yCNEDSWQLPIHAAAQMGHTKilDLLIPLTNRACDTGLNKV---SPVYSAVFGGHEDCLEILLRNGYSPDAQA-----CL 312
Cdd:PHA02876 336 -AADRLYITPLHQASTLDRNK--DIVITLLELGANVNARDYcdkTPIHYAAVRNNVVIINTLLDYGADIEALSqkigtAL 412

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831   313 VFG--------------------------FSSPVCMAFQKDC------------------------------EFFGIVNI 336
Cdd:PHA02876 413 HFAlcgtnpymsvktlidrganvnsknkdLSTPLHYACKKNCkldviemlldngadvnainiqnqypllialEYHGIVNI 492

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|...
gi 7705831   337 LLKYGAQINELH-LAYCLKYEKFSiFRYFLRKGCslgpwnhIYEFVNHAIKAQ 388
Cdd:PHA02876 493 LLHYGAELRDSRvLHKSLNDNMFS-FRYIIAHIC-------IQDFIRHDIRNE 537
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 17-267 2.63e-16

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 81.16  E-value: 2.63e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831    17 AAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMKTFEGfcalhlaasqghwKIVQ 96
Cdd:PHA02874  42 AIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVDTSILPIPCIEK-------------DMIK 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831    97 ILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNgSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQD 176
Cdd:PHA02874 109 TILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVN-IEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKD 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831   177 DFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTkCVELLLSSGADPDLYCNEDSwqlPIHAAAQ 256
Cdd:PHA02874 188 NNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNRS-AIELLINNASINDQDIDGST---PLHHAIN 263

                        250
                 ....*....|..
gi 7705831   257 MGHTK-ILDLLI 267
Cdd:PHA02874 264 PPCDIdIIDILL 275
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 52-302 5.07e-16

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 80.39  E-value: 5.07e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831    52 YHNSVECLQMLINadSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLL 131
Cdd:PHA02874  10 YSGDIEAIEKIIK--NKGNCINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831   132 LQHGANVNGSHSMCGWNS----------------------LHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQY 189
Cdd:PHA02874  88 IDNGVDTSILPIPCIEKDmiktildcgidvnikdaelktfLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKH 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831   190 GKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSwqLPIHAAAqMGHTKILDLLIpl 269
Cdd:PHA02874 168 NFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGF--TPLHNAI-IHNRSAIELLI-- 242

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 7705831   270 TNRAC-DTGLNKVSPVYSAV-FGGHEDCLEILLRN 302
Cdd:PHA02874 243 NNASInDQDIDGSTPLHHAInPPCDIDIIDILLYH 277
Ank_2 pfam12796
Ankyrin repeats (3 copies);
183-267 1.79e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 71.69  E-value: 1.79e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831    183 LFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSgADPDLYCNEDSwqlPIHAAAQMGHTKI 262
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGRT---ALHYAARSGHLEI 76


                  ....*
gi 7705831    263 LDLLI 267
Cdd:pfam12796  77 VKLLL 81
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 42-234 4.38e-15

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 78.13  E-value: 4.38e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831   42 RGW-MPIHEAAYHNSVECLQMLINADSSENYIKMKTFEgfCALHLAASQGHWKIVQILLEAgaDPNATTLEET------- 113
Cdd:cd22192  15 RISeSPLLLAAKENDVQAIKKLLKCPSCDLFQRGALGE--TALHVAALYDNLEAAVVLMEA--APELVNEPMTsdlyqge 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831  114 TPLFLAVENGQIDVLRLLLQHGANVN-----------GSHSMC--GWNSLHQASFQENAEIIKLLLRKGANKECQDDFGI 180
Cdd:cd22192  91 TALHIAVVNQNLNLVRELIARGADVVspratgtffrpGPKNLIyyGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGN 170

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 7705831  181 TPLFV-AAQYGKL---ESLSILISSGANVNCQALDKA------TPLFIAAQEGHTKCVELLLSS 234
Cdd:cd22192 171 TVLHIlVLQPNKTfacQMYDLILSYDKEDDLQPLDLVpnnqglTPFKLAAKEGNIVMFQHLVQK 234
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 17-267 6.43e-15

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 77.41  E-value: 6.43e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831    17 AAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSEN--------YIKMKTFE--------GF 80
Cdd:PHA02876 185 AAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSNINkndlsllkAIRNEDLEtslllydaGF 264

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831    81 CA----------LHLAASQGHW-KIVQILLEAGADPNATTLEETTPLFLAVENG-QIDVLRLLLQHGANVNGSHSMcgWN 148
Cdd:PHA02876 265 SVnsiddckntpLHHASQAPSLsRLVPKLLERGADVNAKNIKGETPLYLMAKNGyDTENIRTLIMLGADVNAADRL--YI 342

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831   149 S-LHQAS-FQENAEIIKLLLRKGANKECQDDFGITPLFVAA------------QYG-KLESLS----------------- 196
Cdd:PHA02876 343 TpLHQAStLDRNKDIVITLLELGANVNARDYCDKTPIHYAAvrnnvviintllDYGaDIEALSqkigtalhfalcgtnpy 422

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 7705831   197 ----ILISSGANVNCQALDKATPLFIAAQEG-HTKCVELLLSSGADPDLYCNEDSWQLPIhaaaQMGHTKILDLLI 267
Cdd:PHA02876 423 msvkTLIDRGANVNSKNKDLSTPLHYACKKNcKLDVIEMLLDNGADVNAINIQNQYPLLI----ALEYHGIVNILL 494
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 49-239 1.23e-14

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 75.80  E-value: 1.23e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831    49 EAAYHNSVECLQMLINADSSENYikmKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVL 128
Cdd:PHA02875   8 DAILFGELDIARRLLDIGINPNF---EIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAV 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831   129 RLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQ 208
Cdd:PHA02875  85 EELLDLGKFADDVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIE 164

                        170       180       190
                 ....*....|....*....|....*....|.
gi 7705831   209 ALDKATPLFIAAQEGHTKCVELLLSSGADPD 239
Cdd:PHA02875 165 DCCGCTPLIIAMAKGDIAICKMLLDSGANID 195
Ank_2 pfam12796
Ankyrin repeats (3 copies);
216-309 1.91e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 68.99  E-value: 1.91e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831    216 LFIAAQEGHTKCVELLLSSGADPDLYCNEDswQLPIHAAAQMGHTKILDLLIPltNRACDTGLNKVSPVYSAVFGGHEDC 295
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNG--RTALHLAAKNGHLEIVKLLLE--HADVNLKDNGRTALHYAARSGHLEI 76

                          90
                  ....*....|....
gi 7705831    296 LEILLRNGYSPDAQ 309
Cdd:pfam12796  77 VKLLLEKGADINVK 90
SOCS_ASB_like cd03716
SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB ...
 457-501 1.52e-13

SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable number of repeats. SSB proteins contain a central SPRY domain and a C-terminal SOCS. Recently, it has been shown that all four SSB proteins interact with the MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), and that SSB-1, SSB-2, and SSB-4 interact with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain.


Pssm-ID: 239686  Cd Length: 42  Bit Score: 64.82  E-value: 1.52e-13
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 7705831  457 ATVPSLTHLCRLEIRSSLKSERLrsdSYISQLPLPRSLHNYLLYE 501
Cdd:cd03716   1 STPRSLQHLCRLAIRRCLGRRRL---ELIKKLPLPPRLKDYLLYE 42
SOCS cd03587
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 458-501 8.55e-13

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239641  Cd Length: 41  Bit Score: 62.49  E-value: 8.55e-13
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 7705831  458 TVPSLTHLCRLEIRSSLKSERLrsdSYISQLPLPRSLHNYLLYE 501
Cdd:cd03587   1 NPRSLQHLCRLAIRRCLGKRRL---DLIDKLPLPPRLKDYLLYK 41
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 24-229 8.65e-13

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 70.29  E-value: 8.65e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831    24 KVLRKLLKKGRSVDVAD-NRGWMPIHEAAYHNSVECLQMLINADSSENyIKMKTFEGfcALHLAASQGHWKIVQILLEAG 102
Cdd:PHA02878 148 EITKLLLSYGADINMKDrHKGNTALHYATENKDQRLTELLLSYGANVN-IPDKTNNS--PLHHAVKHYNKPIVHILLENG 224

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831   103 ADPNATTLEETTPLFLAVEN-GQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQEnaEIIKLLLRKGANKECQDDFGIT 181
Cdd:PHA02878 225 ASTDARDKCGNTPLHISVGYcKDYDILKLLLEHGVDVNAKSYILGLTALHSSIKSE--RKLKLLLEYGADINSLNSYKLT 302

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 7705831   182 PLFVAA-QYGKLESLSILISsgaNVNCQALDKAtplFIAAQEGHTKCVE 229
Cdd:PHA02878 303 PLSSAVkQYLCINIGRILIS---NICLLKRIKP---DIKNSEGFIDNMD 345
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 1-237 1.28e-12

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 69.91  E-value: 1.28e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831     1 MDFTEAYADTCSTVGL-----AAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINAdssenYIKMK 75
Cdd:PHA02878  23 IDHTENYSTSASLIPFiplhqAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMIRS-----INKCS 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831    76 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASF 155
Cdd:PHA02878  98 VFYTLVAIKDAFNNRNVEIFKIILTNRYKNIQTIDLVYIDKKSKDDIIEAEITKLLLSYGADINMKDRHKGNTALHYATE 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831   156 QENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAqeGHTKCVE---LLL 232
Cdd:PHA02878 178 NKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISV--GYCKDYDilkLLL 255


                 ....*
gi 7705831   233 SSGAD 237
Cdd:PHA02878 256 EHGVD 260
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 86-279 4.32e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 68.09  E-value: 4.32e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831    86 AASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGA--NVN--GSHSmcgwnSLHQASFQENAEI 161
Cdd:PHA02875   9 AILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAipDVKypDIES-----ELHDAVEEGDVKA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831   162 IKLLLRkgANKECQDDF---GITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADP 238
Cdd:PHA02875  84 VEELLD--LGKFADDVFykdGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACL 161

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 7705831   239 DLycnEDSWQL-PIHAAAQMGHTKILDLLIpltnracDTGLN 279
Cdd:PHA02875 162 DI---EDCCGCtPLIIAMAKGDIAICKMLL-------DSGAN 193
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 86-239 1.02e-11

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 67.59  E-value: 1.02e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831    86 AASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANV-----NGSHSMcgWNSL---HQASFQe 157
Cdd:PLN03192 532 VASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVhirdaNGNTAL--WNAIsakHHKIFR- 608

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831   158 naeiIKLLLRKGANKECQDDFgitpLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGAD 237
Cdd:PLN03192 609 ----ILYHFASISDPHAAGDL----LCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGAD 680


                 ..
gi 7705831   238 PD 239
Cdd:PLN03192 681 VD 682
PHA03095 PHA03095
ankyrin-like protein; Provisional
 117-371 1.19e-11

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 66.59  E-value: 1.19e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831   117 FLAVENGQIDVLRLLLQHGANVN--GSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYG-KLE 193
Cdd:PHA03095  19 LLNASNVTVEEVRRLLAAGADVNfrGEYGKTPLHLYLHYSSEKVKDIVRLLLEAGADVNAPERCGFTPLHLYLYNAtTLD 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831   194 SLSILISSGANVNCQALDKATPLFI--AAQEGHTKCVELLLSSGADPdlyCNEDSWQL-PIHA-----AAQMghtKILDL 265
Cdd:PHA03095  99 VIKLLIKAGADVNAKDKVGRTPLHVylSGFNINPKVIRLLLRKGADV---NALDLYGMtPLAVllksrNANV---ELLRL 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831   266 LI-----PLTNRAC-DTGLN--KVSPVYSAvfggheDCLEILLRNGYSPDAQAclVFGFSSPVCMAFQKDCEFFGIVNIL 337
Cdd:PHA03095 173 LIdagadVYAVDDRfRSLLHhhLQSFKPRA------RIVRELIRAGCDPAATD--MLGNTPLHSMATGSSCKRSLVLPLL 244

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 7705831   338 LKyGAQINE--------LHLAYClkYEKFSIFRYFLRKGCSL 371
Cdd:PHA03095 245 IA-GISINArnrygqtpLHYAAV--FNNPRACRRLIALGADI 283
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 161-370 2.16e-11

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 65.84  E-value: 2.16e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831   161 IIKLLLRKGANKE-----CQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHT-----KCVEL 230
Cdd:PHA03100  12 IIKVKNIKYIIMEddlndYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYNltdvkEIVKL 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831   231 LLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIpltNRACDTGLNKV---SPVYSAVFGGHED--CLEILLRNGYS 305
Cdd:PHA03100  92 LLEYGANVNAPDNNGITPLLYAISKKSNSYSIVEYLL---DNGANVNIKNSdgeNLLHLYLESNKIDlkILKLLIDKGVD 168

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 7705831   306 PDAqaclvfgfsspvcmafqKDceffgIVNILLKYGAQINE--------LHLAycLKYEKFSIFRYFLRKGCS 370
Cdd:PHA03100 169 INA-----------------KN-----RVNYLLSYGVPINIkdvygftpLHYA--VYNNNPEFVKYLLDLGAN 217
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 17-183 2.64e-11

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 66.43  E-value: 2.64e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831    17 AAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSenyIKMKTFEGFCALHLAASQGHWKIVQ 96
Cdd:PLN03192 532 VASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACN---VHIRDANGNTALWNAISAKHHKIFR 608

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831    97 IL--LEAGADPNATtleeTTPLFLAVENGQIDVLRLLLQHGANVNgSHSMCGWNSLHQASFQENAEIIKLLLRKGANKEC 174
Cdd:PLN03192 609 ILyhFASISDPHAA----GDLLCTAAKRNDLTAMKELLKQGLNVD-SEDHQGATALQVAMAEDHVDMVRLLIMNGADVDK 683

                        170
                 ....*....|..
gi 7705831   175 ---QDDFGITPL 183
Cdd:PLN03192 684 antDDDFSPTEL 695
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 458-499 4.74e-11

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 57.56  E-value: 4.74e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 7705831    458 TVPSLTHLCRLEIRSSLKSERLrsdSYISQLPLPRSLHNYLL 499
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRRL---GAIDKLPLPPLLKDYLL 39
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 17-189 6.43e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 64.21  E-value: 6.43e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831    17 AAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSsenYIKMKTFEGFCALHLAASQGHWKIVQ 96
Cdd:PHA02874 131 AIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGA---YANVKDNNGESPLHNAAEYGDYACIK 207

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831    97 ILLEAGADPNATTLEETTPLFLAVENGQiDVLRLLLQHgANVNgSHSMCGWNSLHQA-SFQENAEIIKLLLRKGANKECQ 175
Cdd:PHA02874 208 LLIDHGNHIMNKCKNGFTPLHNAIIHNR-SAIELLINN-ASIN-DQDIDGSTPLHHAiNPPCDIDIIDILLYHKADISIK 284

                        170
                 ....*....|....
gi 7705831   176 DDFGITPLFVAAQY 189
Cdd:PHA02874 285 DNKGENPIDTAFKY 298
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 7-139 1.18e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 63.47  E-value: 1.18e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831     7 YADTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENyikMKTFEGFCALHLA 86
Cdd:PHA02875  99 YKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLD---IEDCCGCTPLIIA 175

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 7705831    87 ASQGHWKIVQILLEAGADPNATTLE-ETTPLFLAVENGQIDVLRLLLQHGANVN 139
Cdd:PHA02875 176 MAKGDIAICKMLLDSGANIDYFGKNgCVAALCYAIENNKIDIVRLFIKRGADCN 229
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 21-139 5.10e-10

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 61.60  E-value: 5.10e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831    21 GNVKVLRKLLKKGRSVDVADNRGWMPIHEAAY--HNSVECLQMLI------NADSSENY-------IKMKTFEGFCALHL 85
Cdd:PHA03100 119 NSYSIVEYLLDNGANVNIKNSDGENLLHLYLEsnKIDLKILKLLIdkgvdiNAKNRVNYllsygvpINIKDVYGFTPLHY 198

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 7705831    86 AASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVN 139
Cdd:PHA03100 199 AVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIK 252
TRPV3 cd22194
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a ...
 58-200 5.90e-10

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a temperature-sensitive Transient Receptor Potential (TRP) ion channel that is activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. TRPV3 function is regulated by physiological factors such as extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. It is expressed in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice have abnormal hair morphogenesis and compromised skin barrier function. It may play roles in inflammatory skin disorders, such as itch and pain sensation. TRPV3 is also expressed by many neuronal and non-neuronal tissues, showing that TRPV3 might play roles in other unknown cellular and physiological functions. TRPV3 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411978 [Multi-domain]  Cd Length: 680  Bit Score: 61.70  E-value: 5.90e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831   58 CLQMLINADSSEnyikmKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEE--------------TTPLFLAVENG 123
Cdd:cd22194 125 ILDRFINAEYTE-----EAYEGQTALNIAIERRQGDIVKLLIAKGADVNAHAKGVffnpkykhegfyfgETPLALAACTN 199

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831  124 QIDVLRLLLQHGANVNGSHSMCGWNSLH------QASFQENAEIIKL---LLRKGANKECQ---DDFGITPLFVAAQYGK 191
Cdd:cd22194 200 QPEIVQLLMEKESTDITSQDSRGNTVLHalvtvaEDSKTQNDFVKRMydmILLKSENKNLEtirNNEGLTPLQLAAKMGK 279


                ....*....
gi 7705831  192 LESLSILIS 200
Cdd:cd22194 280 AEILKYILS 288
PHA02989 PHA02989
ankyrin repeat protein; Provisional
 93-206 1.41e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222954 [Multi-domain]  Cd Length: 494  Bit Score: 60.14  E-value: 1.41e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831    93 KIVQILLEAGADPNATTLEETTPLFLAVENGQI---DVLRLLLQHGANVNGSHSMCGWNSLHQ--ASFQENAEIIKLLLR 167
Cdd:PHA02989  89 KIVKLLLKFGADINLKTFNGVSPIVCFIYNSNInncDMLRFLLSKGINVNDVKNSRGYNLLHMylESFSVKKDVIKILLS 168

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 7705831   168 KGANK-ECQDDFGITPLFV----AAQYGKLESLSILISSGANVN 206
Cdd:PHA02989 169 FGVNLfEKTSLYGLTPMNIylrnDIDVISIKVIKYLIKKGVNIE 212
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 77-134 2.10e-09

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 59.91  E-value: 2.10e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 7705831    77 FEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQH 134
Cdd:PTZ00322 113 YDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRH 170
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 460-501 7.61e-09

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 51.26  E-value: 7.61e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 7705831     460 PSLTHLCRLEIRSSLKSerlrsdsyISQLPLPRSLHNYLLYE 501
Cdd:smart00969   1 RSLQHLCRLAIRRSLGG--------IDKLPLPPRLKDYLLYY 34
Ank_4 pfam13637
Ankyrin repeats (many copies);
181-232 4.31e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 49.58  E-value: 4.31e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 7705831    181 TPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLL 232
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_4 pfam13637
Ankyrin repeats (many copies);
17-63 4.75e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 49.58  E-value: 4.75e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 7705831     17 AAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLI 63
Cdd:pfam13637   8 AAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_4 pfam13637
Ankyrin repeats (many copies);
82-132 5.90e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 49.20  E-value: 5.90e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 7705831     82 ALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLL 132
Cdd:pfam13637   4 ALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_4 pfam13637
Ankyrin repeats (many copies);
214-267 6.32e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 49.20  E-value: 6.32e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 7705831    214 TPLFIAAQEGHTKCVELLLSSGADPDlYCNEDSWQlPIHAAAQMGHTKILDLLI 267
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADIN-AVDGNGET-ALHFAASNGNVEVLKLLL 54
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 114-274 8.00e-08

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 55.02  E-value: 8.00e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831  114 TPLFLAV-ENGQIDVLRLLLQHGANV--NGSHsmcGWNSLHQASFQENAEIIKLLLRKG---ANKECQDDF--GITPLFV 185
Cdd:cd22192  19 SPLLLAAkENDVQAIKKLLKCPSCDLfqRGAL---GETALHVAALYDNLEAAVVLMEAApelVNEPMTSDLyqGETALHI 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831  186 AAQYGKLESLSILISSGANVncqALDKAT-----------------PLFIAAQEGHTKCVELLLSSGADPDlycNEDSW- 247
Cdd:cd22192  96 AVVNQNLNLVRELIARGADV---VSPRATgtffrpgpknliyygehPLSFAACVGNEEIVRLLIEHGADIR---AQDSLg 169

                       170       180
                ....*....|....*....|....*..
gi 7705831  248 QLPIHaaaqmghtkILdLLIPLTNRAC 274
Cdd:cd22192 170 NTVLH---------IL-VLQPNKTFAC 186
Ank_4 pfam13637
Ankyrin repeats (many copies);
112-166 8.15e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 48.81  E-value: 8.15e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 7705831    112 ETTPLFLAVENGQIDVLRLLLQHGANVNGSHSmCGWNSLHQASFQENAEIIKLLL 166
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDG-NGETALHFAASNGNVEVLKLLL 54
SOCS_ASB14 cd03730
SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a ...
 461-502 8.80e-08

SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239700  Cd Length: 57  Bit Score: 48.69  E-value: 8.80e-08
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 7705831  461 SLTHLCRLEIRSSLKSERLRSDSYISQLPLPRSLHNYLLYED 502
Cdd:cd03730   5 SLKHLCRLKIRACMGRLRLRCPVFMSFLPLPNRLKAYILYKE 46
PHA02884 PHA02884
ankyrin repeat protein; Provisional
 52-219 1.29e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165212 [Multi-domain]  Cd Length: 300  Bit Score: 53.45  E-value: 1.29e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831    52 YHNSVECLQMLINADSSENYIKMKTFEGFC---ALHLAASQGHWKIVQILLEAGADPNA----TTLEETTPLFLAVENGQ 124
Cdd:PHA02884   3 IINLIDIITLLCRIFYIIFYIAIKKKNKICianILYSSIKFHYTDIIDAILKLGADPEApfplSENSKTNPLIYAIDCDN 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831   125 IDVLRLLLQHGANVNgshsmcgwnslhqaSFQENAEIiklllrkgankecqddfgiTPLFVAAQYGKLESLSILISSGAN 204
Cdd:PHA02884  83 DDAAKLLIRYGADVN--------------RYAEEAKI-------------------TPLYISVLHGCLKCLEILLSYGAD 129

                        170
                 ....*....|....*
gi 7705831   205 VNCQALDKATPLFIA 219
Cdd:PHA02884 130 INIQTNDMVTPIELA 144
SOCS_SSB1_4 cd03718
SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box ...
 461-501 1.30e-07

SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF) and also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239688  Cd Length: 42  Bit Score: 48.07  E-value: 1.30e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 7705831  461 SLTHLCRLEIRSSLKSERLRSdsyISQLPLPRSLHNYLLYE 501
Cdd:cd03718   5 PLMDLCRRRVRVALGRDRLEE---IEQLPLPPSLKNYLLYQ 42
PHA02884 PHA02884
ankyrin repeat protein; Provisional
 160-244 1.53e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165212 [Multi-domain]  Cd Length: 300  Bit Score: 53.06  E-value: 1.53e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831   160 EIIKLLLRKGANKECQDDFG----ITPLFVAAQYGKLESLSILISSGANVNCQALD-KATPLFIAAQEGHTKCVELLLSS 234
Cdd:PHA02884  47 DIIDAILKLGADPEAPFPLSenskTNPLIYAIDCDNDDAAKLLIRYGADVNRYAEEaKITPLYISVLHGCLKCLEILLSY 126

                         90
                 ....*....|
gi 7705831   235 GADPDLYCNE 244
Cdd:PHA02884 127 GADINIQTND 136
SOCS_SOCS_like cd03717
SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of ...
 459-500 2.16e-07

SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. These intracellular proteins regulate the responses of immune cells to cytokines. Identified as negative regulators of the cytokine-JAK-STAT pathway, they seem to play a role in many immunological and pathological processes. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. Related SOCS boxes are also present in Rab40-like proteins and insect proteins of unknown function that also contain a NEUZ (domain in neuralized proteins) domain.


Pssm-ID: 239687  Cd Length: 39  Bit Score: 47.21  E-value: 2.16e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 7705831  459 VPSLTHLCRLEIRSSLKSERlrsdsyISQLPLPRSLHNYLLY 500
Cdd:cd03717   3 VRSLQHLCRFVIRQCTRRDL------IDQLPLPRRLKDYLKE 38
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 73-178 2.32e-07

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 53.36  E-value: 2.32e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831    73 KMKTFEgFCalHLAASqGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMcGWNSLHQ 152
Cdd:PTZ00322  80 HMLTVE-LC--QLAAS-GDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKD-GKTPLEL 154

                         90       100
                 ....*....|....*....|....*.
gi 7705831   153 ASFQENAEIIKLLLRkgankECQDDF 178
Cdd:PTZ00322 155 AEENGFREVVQLLSR-----HSQCHF 175
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 11-139 4.72e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 52.27  E-value: 4.72e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831    11 CSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLInadSSENYIKMKTFEGFCALHLAASqg 90
Cdd:PHA02874 158 CYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLI---DHGNHIMNKCKNGFTPLHNAII-- 232

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 7705831    91 HWKIVQILLEAGADPNATTLEETTPLFLAVENG-QIDVLRLLLQHGANVN 139
Cdd:PHA02874 233 HNRSAIELLINNASINDQDIDGSTPLHHAINPPcDIDIIDILLYHKADIS 282
TRPV1 cd22196
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 1; Vanilloid receptor 1 ...
 59-199 6.19e-07

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 1; Vanilloid receptor 1 (TRPV1), a capsaicin (vanilloid) receptor, is the founding member of the vanilloid TRP subfamily (TRPV). In humans, it is expressed in the brain, kidney, pancreas, testis, uterus, spleen, stomach, small intestine, lung and liver. TRPV1 has been implicated to have function in thermo-sensation (heat), autonomic thermoregulation, nociception, food intake regulation, and multiple functions in the gastrointestinal (GI) tract. The receptor has also been involved in growth cone guidance, long-term depression, endocannabinoid signaling and osmosensing in the central nervous system. TRPV1 is up regulated in several human pathological conditions including vulvodynia, GI inflammation, Crohn's disease and ulcerative colitis. TRPV1 knock-out mice exhibit impaired sensation to thermal-mechanical acute pain. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411980 [Multi-domain]  Cd Length: 649  Bit Score: 52.12  E-value: 6.19e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831   59 LQMLINADSSENYIKMKTfegfcALHLAASQGHWKIVQILLEAGADPNATTLEE--------------TTPLFLAVENGQ 124
Cdd:cd22196  79 LKEFVNAAYTDSYYKGQT-----ALHIAIERRNMHLVELLVQNGADVHARASGEffkkkkggpgfyfgELPLSLAACTNQ 153

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831  125 IDVLRLLLQH---GANVNGSHSMcGWNSLHQA-----SFQENAEIIKL----LLRKGAN-------KECQDDFGITPLFV 185
Cdd:cd22196 154 LDIVKFLLENphsPADISARDSM-GNTVLHALvevadNTPENTKFVTKmyneILILGAKirpllklEEITNKKGLTPLKL 232

                       170
                ....*....|....
gi 7705831  186 AAQYGKLESLSILI 199
Cdd:cd22196 233 AAKTGKIGIFAYIL 246
SOCS_ASB4_ASB18 cd03723
SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members ...
 458-501 1.16e-06

SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239693  Cd Length: 48  Bit Score: 45.51  E-value: 1.16e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 7705831  458 TVPSLTHLCRLEIRSSLKSerlRSDSYISQLPLPRSLHNYLLYE 501
Cdd:cd03723   2 TPRSLQHLCRCAIRKLLGS---RCHKLVPQLSLPTSLKNYLLLE 42
PHA03095 PHA03095
ankyrin-like protein; Provisional
 24-132 1.25e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 50.79  E-value: 1.25e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831    24 KVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQM--LINADSSENYikmKTFEGFCALHLAASQGHWKIVQILLEA 101
Cdd:PHA03095 203 RIVRELIRAGCDPAATDMLGNTPLHSMATGSSCKRSLVlpLLIAGISINA---RNRYGQTPLHYAAVFNNPRACRRLIAL 279

                         90       100       110
                 ....*....|....*....|....*....|.
gi 7705831   102 GADPNATTLEETTPLFLAVENGQIDVLRLLL 132
Cdd:PHA03095 280 GADINAVSSDGNTPLSLMVRNNNGRAVRAAL 310
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 156-345 1.29e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 51.22  E-value: 1.29e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831   156 QENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVEL----- 230
Cdd:PHA02876 155 QDELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAiidnr 234

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831   231 ---------LLSSGADPDLYCN-------------EDSWQLPIHAAAQmghTKILDLLIP-LTNRACDTGLNKV---SPV 284
Cdd:PHA02876 235 sninkndlsLLKAIRNEDLETSlllydagfsvnsiDDCKNTPLHHASQ---APSLSRLVPkLLERGADVNAKNIkgeTPL 311

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 7705831   285 YSAVFGGHE-DCLEILLRNGYSPDAQACLvfgFSSPVCMAFQKDcEFFGIVNILLKYGAQIN 345
Cdd:PHA02876 312 YLMAKNGYDtENIRTLIMLGADVNAADRL---YITPLHQASTLD-RNKDIVITLLELGANVN 369
SOCS_ASB15 cd03731
SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a ...
 461-502 1.48e-06

SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB15 is expressed predominantly in skeletal muscle and participates in the regulation of protein turnover and muscle cell development by stimulating protein synthesis and regulating differentiation of muscle cells. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239701  Cd Length: 56  Bit Score: 45.21  E-value: 1.48e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 7705831  461 SLTHLCRLEIRSSLKSERLRSDSYISQLPLPRSLHNYLLYED 502
Cdd:cd03731   5 PLKHLCRLKIRKLMGLQKLQQPSSMKKLPLPPALKRYILYKE 46
SOCS_SSB1 cd03744
SOCS (suppressors of cytokine signaling) box of SSB1 (SPRY domain-containing SOCS box proteins) ...
 461-501 4.37e-06

SOCS (suppressors of cytokine signaling) box of SSB1 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), both the absence and the presence of HGF and enhances the HGF-MET-induced mitogen-activated protein kinases Erk-transcription factor Elk-1-serum response elements (SRE) pathway. SSB1, like SSB2 and SSB4, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239713  Cd Length: 42  Bit Score: 43.43  E-value: 4.37e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 7705831  461 SLTHLCRLEIRSSLKSERLrsdSYISQLPLPRSLHNYLLYE 501
Cdd:cd03744   5 PLMDLCRRSVRLALGRERL---SEIHTLPLPASLKNYLLYQ 42
PHA02798 PHA02798
ankyrin-like protein; Provisional
 104-244 4.93e-06

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 49.06  E-value: 4.93e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831   104 DPNATTLEETT-PLFLAVENGQIDVLRLLLQHGANVNG-----SHSMCGWNSlHQASFQENAEIIKLLLRKGANKECQDD 177
Cdd:PHA02798  29 NPNEIVNEYSIfQKYLQRDSPSTDIVKLFINLGANVNGldneySTPLCTILS-NIKDYKHMLDIVKILIENGADINKKNS 107

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 7705831   178 FGITPLFVAAQYG---KLESLSILISSGANVNCQALDKATPLFIAAQEGHT---KCVELLLSSGADPDLYCNE 244
Cdd:PHA02798 108 DGETPLYCLLSNGyinNLEILLFMIENGADTTLLDKDGFTMLQVYLQSNHHidiEIIKLLLEKGVDINTHNNK 180
PHA02946 PHA02946
ankyin-like protein; Provisional
 78-234 5.14e-06

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 48.90  E-value: 5.14e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831    78 EGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFL--AVENGQIDVLRLLLQHGANVNGSHSMCGWNSLhQASF 155
Cdd:PHA02946  71 DGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLYYlsGTDDEVIERINLLVQYGAKINNSVDEEGCGPL-LACT 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831   156 QENAEIIKLLLRKGANKECQDDFGITPL--FVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQE--GHTKCVELL 231
Cdd:PHA02946 150 DPSERVFKKIMSIGFEARIVDKFGKNHIhrHLMSDNPKASTISWMMKLGISPSKPDHDGNTPLHIVCSKtvKNVDIINLL 229


                 ...
gi 7705831   232 LSS 234
Cdd:PHA02946 230 LPS 232
TRPV1-4 cd22193
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are ...
 59-200 6.05e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are thermo-sensing channels that function directly in temperature-sensing and nociception; they share substantial structural and functional properties. Transient Receptor Potential (TRP) ion channels activated by temperature (thermo TRPs) are important molecular players in acute, inflammatory, and chronic pain states. So far, 11 TRP channels in mammalian cells have been identified as thermosensitive TRP (thermo-TRP) channels. TRPV1-4 channels are activated by different heat temperatures, for example, TRPV1 and TRPV2 are activated by high temperatures (>43C and >55C, respectively). TRPV1-4 belong to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411977 [Multi-domain]  Cd Length: 607  Bit Score: 49.02  E-value: 6.05e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831   59 LQMLINADSSENYikmktFEGFCALHLAASQGHWKIVQILLEAGADPNAT--------TLEET------TPLFLAVENGQ 124
Cdd:cd22193  61 LKRFINAEYTDEY-----YEGQTALHIAIERRQGDIVALLVENGADVHAHakgrffqpKYQGEgfyfgeLPLSLAACTNQ 135

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831  125 IDVLRLLLQHG---ANVNGSHSMcGWNSLHQA-----SFQENAEIIK----LLLRKGAN-------KECQDDFGITPLFV 185
Cdd:cd22193 136 PDIVQYLLENEhqpADIEAQDSR-GNTVLHALvtvadNTKENTKFVTrmydMILIRGAKlcptvelEEIRNNDGLTPLQL 214

                       170
                ....*....|....*
gi 7705831  186 AAQYGKLESLSILIS 200
Cdd:cd22193 215 AAKMGKIEILKYILQ 229
SOCS_SSB4 cd03743
SOCS (suppressors of cytokine signaling) box of SSB4 (SPRY domain-containing SOCS box ...
 462-501 6.46e-06

SOCS (suppressors of cytokine signaling) box of SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF). SSB4, like SSB2 and SSB1, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239712  Cd Length: 42  Bit Score: 43.02  E-value: 6.46e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 7705831  462 LTHLCRLEIRSSLKSERLRsdsYISQLPLPRSLHNYLLYE 501
Cdd:cd03743   6 LMDLCRRSARQALGRHRLH---HIQSLPLPQTLKNYLQYQ 42
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 162-246 1.04e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 48.36  E-value: 1.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831   162 IKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSsgadpdlY 241
Cdd:PTZ00322  98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSR-------H 170


                 ....*
gi 7705831   242 CNEDS 246
Cdd:PTZ00322 171 SQCHF 175
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 114-139 1.13e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 42.19  E-value: 1.13e-05
                           10        20
                   ....*....|....*....|....*.
gi 7705831     114 TPLFLAVENGQIDVLRLLLQHGANVN 139
Cdd:smart00248   4 TPLHLAAENGNLEVVKLLLDKGADIN 29
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 78-109 1.31e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 41.89  E-value: 1.31e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 7705831     78 EGFCALHLAASQ-GHWKIVQILLEAGADPNATT 109
Cdd:pfam00023   1 DGNTPLHLAAGRrGNLEIVKLLLSKGADVNARD 33
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
192-368 1.43e-05

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 46.87  E-value: 1.43e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831  192 LESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLycNEDSWQLPIHAAAQMGHTKILDLLIPLTN 271
Cdd:COG0666   1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALAL--ADALGALLLLAAALAGDLLVALLLLAAGA 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831  272 RACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQAclVFGFSSPVCMAFQKDCEffgIVNILLKYGAQINE----- 346
Cdd:COG0666  79 DINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARD--KDGETPLHLAAYNGNLE---IVKLLLEAGADVNAqdndg 153

                       170       180
                ....*....|....*....|....*
gi 7705831  347 ---LHLAYCLKYEKfsIFRYFLRKG 368
Cdd:COG0666 154 ntpLHLAAANGNLE--IVKLLLEAG 176
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 16-151 2.73e-05

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 47.00  E-value: 2.73e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831     16 LAAREGNVKVLRKLLK-KGRSVDVADNRgwmpIHEAA--YHNSVE-CLQMLINADSSE------NYIKMKTF-EGFCALH 84
Cdd:TIGR00870  58 VAAIENENLELTELLLnLSCRGAVGDTL----LHAISleYVDAVEaILLHLLAAFRKSgplelaNDQYTSEFtPGITALH 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831     85 LAASQGHWKIVQILLEAGADPNAT-------TLEETT-------PLFLAVENGQIDVLRLLLQHGANVNGSHSMcGWNSL 150
Cdd:TIGR00870 134 LAAHRQNYEIVKLLLERGASVPARacgdffvKSQGVDsfyhgesPLNAAACLGSPSIVALLSEDPADILTADSL-GNTLL 212


                  .
gi 7705831    151 H 151
Cdd:TIGR00870 213 H 213
PHA02989 PHA02989
ankyrin repeat protein; Provisional
 24-232 2.88e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222954 [Multi-domain]  Cd Length: 494  Bit Score: 46.66  E-value: 2.88e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831    24 KVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIK-MKTFEGFCALH--LAASQGHWKIVQILLE 100
Cdd:PHA02989  89 KIVKLLLKFGADINLKTFNGVSPIVCFIYNSNINNCDMLRFLLSKGINVNdVKNSRGYNLLHmyLESFSVKKDVIKILLS 168

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831   101 AGADP-NATTLEETTPLFLAVENG----QIDVLRLLLQHGANVNGShsmcgwNSLHQA---SFQENAEI-----IKLL-- 165
Cdd:PHA02989 169 FGVNLfEKTSLYGLTPMNIYLRNDidviSIKVIKYLIKKGVNIETN------NNGSESvleSFLDNNKIlskkeFKVLnf 242

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 7705831   166 LRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLL 232
Cdd:PHA02989 243 ILKYIKINKKDKKGFNPLLISAKVDNYEAFNYLLKLGDDIYNVSKDGDTVLTYAIKHGNIDMLNRIL 309
SOCS smart00253
suppressors of cytokine signalling; suppressors of cytokine signalling
 459-500 3.18e-05

suppressors of cytokine signalling; suppressors of cytokine signalling


Pssm-ID: 128549  Cd Length: 43  Bit Score: 41.13  E-value: 3.18e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 7705831     459 VPSLTHLCRLEIRSSLKSErlrsdsYISQLPLPRSLHNYLLY 500
Cdd:smart00253   7 VPSLQHLCRFTIRRCTRTD------QIKTLPLPPKLKDYLSY 42
PHA02798 PHA02798
ankyrin-like protein; Provisional
 94-171 3.34e-05

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 46.37  E-value: 3.34e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831    94 IVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLL---QHGANVNgSHSMCGWNSLH---QASFQENAEIIKLLLR 167
Cdd:PHA02798  91 IVKILIENGADINKKNSDGETPLYCLLSNGYINNLEILLfmiENGADTT-LLDKDGFTMLQvylQSNHHIDIEIIKLLLE 169


                 ....
gi 7705831   168 KGAN 171
Cdd:PHA02798 170 KGVD 173
SOCS_SOCS7 cd03741
SOCS (suppressors of cytokine signaling) box of SOCS7-like proteins. Together with CIS1, the ...
 459-500 3.36e-05

SOCS (suppressors of cytokine signaling) box of SOCS7-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS7 is important in the functioning of neuronal cells. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239710  Cd Length: 49  Bit Score: 41.24  E-value: 3.36e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 7705831  459 VPSLTHLCRLEIRSSLkserlRSDsYISQLPLPRSLHNYLLY 500
Cdd:cd03741   3 VQSLQHLCRFVIRKLV-----RRD-HIPALPLPRRLIDYLRE 38
SOCS_WSB_SWIP cd03733
SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily ...
 458-500 4.15e-05

SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2), and SWiP-1 (SOCS box and WD-repeats in Protein), a WD40-containing protein that is expressed in embryonic structures of chickens and regulated by Sonic Hedgehog (Shh), as well as, their isoforms WSB-2 and SWiP-2. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239702  Cd Length: 39  Bit Score: 40.87  E-value: 4.15e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 7705831  458 TVPSLTHLCRLEIRSSLKSERlrsdsyISQLPLPRSLHNYLLY 500
Cdd:cd03733   2 VVSSLQHLCRMALRRVMTTQQ------VLALPIPKKMKEFLTY 38
Ank_2 pfam12796
Ankyrin repeats (3 copies);
251-345 4.84e-05

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 42.03  E-value: 4.84e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831    251 IHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNgyspdAQACLVFGFSSPVCMAFQKDCef 330
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-----ADVNLKDNGRTALHYAARSGH-- 73

                          90
                  ....*....|....*
gi 7705831    331 FGIVNILLKYGAQIN 345
Cdd:pfam12796  74 LEIVKLLLEKGADIN 88
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 114-267 4.86e-05

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 46.23  E-value: 4.86e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831    114 TPLF-LAVENGQIDVLRLLLQHGANVNgshsmCGWNSLHQAS--FQENAE-IIKLLLRKG--------ANKECQDDF--G 179
Cdd:TIGR00870  54 SALFvAAIENENLELTELLLNLSCRGA-----VGDTLLHAISleYVDAVEaILLHLLAAFrksgplelANDQYTSEFtpG 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831    180 ITPLFVAAQYGKLESLSILISSGANVNCQAldkatplfiaaqeghtKCVELLLSSGADpDLYCNEdswqLPIHAAAQMGH 259
Cdd:TIGR00870 129 ITALHLAAHRQNYEIVKLLLERGASVPARA----------------CGDFFVKSQGVD-SFYHGE----SPLNAAACLGS 187


                  ....*...
gi 7705831    260 TKILDLLI 267
Cdd:TIGR00870 188 PSIVALLS 195
SOCS_SSB2 cd03719
SOCS (suppressors of cytokine signaling) box of SSB2 (SPRY domain-containing SOCS box proteins) ...
 461-501 7.72e-05

SOCS (suppressors of cytokine signaling) box of SSB2 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB2 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF). SSB2, like SSB4 and SSB1, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239689  Cd Length: 42  Bit Score: 40.00  E-value: 7.72e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 7705831  461 SLTHLCRLEIRSSLKSERLrsdSYISQLPLPRSLHNYLLYE 501
Cdd:cd03719   5 SLLHLSRLCVRHALGDTRL---GQVSALPLPPAMKRYLLYQ 42
Ank_4 pfam13637
Ankyrin repeats (many copies);
146-199 1.25e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.95  E-value: 1.25e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 7705831    146 GWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILI 199
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_5 pfam13857
Ankyrin repeats (many copies);
78-119 1.96e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 39.25  E-value: 1.96e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 7705831     78 EGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLA 119
Cdd:pfam13857  15 EGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 45-212 2.18e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 44.10  E-value: 2.18e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831   45 MPIHEAAyhNSVECLQMLINADSSENYikmktFEGFCALHLAASQGHWKIVQILLEAGAD----PNATTLEETT------ 114
Cdd:cd21882  46 MLLLEAA--PDSGNPKELVNAPCTDEF-----YQGQTALHIAIENRNLNLVRLLVENGADvsarATGRFFRKSPgnlfyf 118

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831  115 ---PLFLAVENGQIDVLRLLLQHGANVNGSHSM--CGWNSLHQASFQEN---------AEIIKLLLRKGAN-------KE 173
Cdd:cd21882 119 gelPLSLAACTNQEEIVRLLLENGAQPAALEAQdsLGNTVLHALVLQADntpensafvCQMYNLLLSYGAHldptqqlEE 198

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 7705831  174 CQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDK 212
Cdd:cd21882 199 IPNHQGLTPLKLAAVEGKIVMFQHILQREFSGPYQPLSR 237
SOCS_WSB2_SWIP2 cd03745
SOCS (suppressors of cytokine signaling) box of WSB2/SWiP2-like proteins. This family consists ...
 458-500 2.21e-04

SOCS (suppressors of cytokine signaling) box of WSB2/SWiP2-like proteins. This family consists of WSB-2 (SOCS-box-containing WD-40 protein) and SWiP-2 (SOCS box and WD-repeats in Protein). No functional information is available for WSB2 or SWiP-2, but limited information is available for the isoforms WSB-1 and SWiP-1. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239714  Cd Length: 39  Bit Score: 38.72  E-value: 2.21e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 7705831  458 TVPSLTHLCRLEIRSSLKSERlrsdsyISQLPLPRSLHNYLLY 500
Cdd:cd03745   2 VLPSLRHLCRKALRHFLTTYQ------VLALPIPKKMKEFLTY 38
PHA02798 PHA02798
ankyrin-like protein; Provisional
 23-219 2.31e-04

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 43.67  E-value: 2.31e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831    23 VKVLRKLLKKGRSVDVADNRGWMPI-----HEAAYHNSVECLQMLI--NADssenyIKMKTFEG----FCALHlAASQGH 91
Cdd:PHA02798  51 TDIVKLFINLGANVNGLDNEYSTPLctilsNIKDYKHMLDIVKILIenGAD-----INKKNSDGetplYCLLS-NGYINN 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831    92 WKIVQILLEAGADPNATTLEETTPLFLAVENG---QIDVLRLLLQHGANVNGSHSMCGWNSLHqASFQEN-----AEIIK 163
Cdd:PHA02798 125 LEILLFMIENGADTTLLDKDGFTMLQVYLQSNhhiDIEIIKLLLEKGVDINTHNNKEKYDTLH-CYFKYNidridADILK 203

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831   164 LLLRKG--ANKECQ-------------------------------------DDFGITPLFVAAQYGKLESLSILISSGAN 204
Cdd:PHA02798 204 LFVDNGfiINKENKshkkkfmeylnsllydnkrfkknildfifsyidinqvDELGFNPLYYSVSHNNRKIFEYLLQLGGD 283

                        250
                 ....*....|....*
gi 7705831   205 VNCQALDKATPLFIA 219
Cdd:PHA02798 284 INIITELGNTCLFTA 298
Ank_4 pfam13637
Ankyrin repeats (many copies);
250-300 2.43e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 38.79  E-value: 2.43e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 7705831    250 PIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILL 300
Cdd:pfam13637   4 ALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
SOCS_WSB1_SWIP1 cd03746
SOCS (suppressors of cytokine signaling) box of WSB1/SWiP1-like proteins. This subfamily ...
 459-501 2.59e-04

SOCS (suppressors of cytokine signaling) box of WSB1/SWiP1-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2) and SWiP-1 (SOCS box and WD-repeats in Protein), a WD40-containing protein that is expressed in embryonic structures of chickens and regulated by Sonic Hedgehog (Shh). The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239715  Cd Length: 40  Bit Score: 38.64  E-value: 2.59e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 7705831  459 VPSLTHLCRLEIRsslkseRLRSDSYISQLPLPRSLHNYLLYE 501
Cdd:cd03746   3 VASLQHLCRMAIR------RVMPTQQVKELPIPSKLLEFLTYR 39
SOCS_ASB2 cd03721
SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a ...
 462-502 4.31e-04

SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB2 targets specific proteins to destruction by the proteasome in leukemia cells that have been induced to differentiate. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239691  Cd Length: 45  Bit Score: 37.92  E-value: 4.31e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 7705831  462 LTHLCRLEIRSSLKSERLRsdsYISQLPLPRSLHNYLLYED 502
Cdd:cd03721   6 LAHLCRLKVRTLIGINRIK---LIDTLPLPPRLIRYLNHQE 43
SOCS_ASB5 cd03724
SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a ...
 457-500 5.21e-04

SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB5 has been implicated in the initiation of arteriogenesis. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239694  Cd Length: 42  Bit Score: 37.93  E-value: 5.21e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 7705831  457 ATVPSLTHLCRLEIRSSLKSERLRsdsYISQLPLPRSLHNYLLY 500
Cdd:cd03724   1 ATPSSLCQLCRLCIRNYIGRSRLH---LIPQLQLPTLLKNFLQY 41
TRPV2 cd22197
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 2; TRPV2 is closely ...
 60-193 5.42e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 2; TRPV2 is closely related to TRPV1, sharing high sequence identity (>50%), but TRPV2 shows a higher temperature threshold and sensitivity for activation than TRPV1. TRPV2 can be stimulated by ligands or lipids, and is involved in osmosensation and mechanosensation. TRPV2 is expressed in both neuronal and non-neuronal tissues, and it has been implicated in diverse physiological and pathophysiological processes, including cardiac-structure maintenance, innate immunity, and cancer. TRPV2 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411981 [Multi-domain]  Cd Length: 640  Bit Score: 42.53  E-value: 5.42e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831   60 QMLINADSSENYikmktFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEE-------------TTPLFLAVENGQID 126
Cdd:cd22197  80 KPLVNAQCTDEY-----YRGHSALHIAIEKRSLQCVKLLVENGADVHARACGRffqkkqgtcfyfgELPLSLAACTKQWD 154

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831  127 VLRLLLQHG---ANVNGSHSMcGWNSLHQASF-----QENAEI-IKL---LLRKGAN-------KECQDDFGITPLFVAA 187
Cdd:cd22197 155 VVNYLLENPhqpASLQAQDSL-GNTVLHALVMiadnsPENSALvIKMydgLLQAGARlcptvqlEEISNHEGLTPLKLAA 233


                ....*.
gi 7705831  188 QYGKLE 193
Cdd:cd22197 234 KEGKIE 239
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 114-139 5.61e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 37.24  E-value: 5.61e-04
                          10        20
                  ....*....|....*....|....*.
gi 7705831    114 TPLFLAVENGQIDVLRLLLQHGANVN 139
Cdd:pfam13606   4 TPLHLAARNGRLEIVKLLLENGADIN 29
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 9-116 6.47e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 42.29  E-value: 6.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831     9 DTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMKTfeGFCALHLAAS 88
Cdd:PHA02875 134 DKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNG--CVAALCYAIE 211

                         90       100       110
                 ....*....|....*....|....*....|.
gi 7705831    89 QGHWKIVQILLEAGADPNATTL---EETTPL 116
Cdd:PHA02875 212 NNKIDIVRLFIKRGADCNIMFMiegEECTIL 242
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 211-240 6.56e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.18  E-value: 6.56e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 7705831     211 DKATPLFIAAQEGHTKCVELLLSSGADPDL 240
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 82-107 7.03e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.18  E-value: 7.03e-04
                           10        20
                   ....*....|....*....|....*.
gi 7705831      82 ALHLAASQGHWKIVQILLEAGADPNA 107
Cdd:smart00248   5 PLHLAAENGNLEVVKLLLDKGADINA 30
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 114-139 7.40e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 36.88  E-value: 7.40e-04
                          10        20
                  ....*....|....*....|....*..
gi 7705831    114 TPLFLAVE-NGQIDVLRLLLQHGANVN 139
Cdd:pfam00023   4 TPLHLAAGrRGNLEIVKLLLSKGADVN 30
SOCS_CIS1 cd03734
SOCS (suppressors of cytokine signaling) box of CIS (cytokine-inducible SH2 protein) 1-like ...
 458-498 7.62e-04

SOCS (suppressors of cytokine signaling) box of CIS (cytokine-inducible SH2 protein) 1-like proteins. Together with the SOCS proteins, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. CIS1, like SOCS1 and SOCS3, is involved in the down-regulation of the JAK/STAT pathway. CIS1 binds to cytokine receptors at STAT5-docking sites, which prohibits recruitment of STAT5 to the receptor signaling complex and results in the down-regulation of activation by STAT5.


Pssm-ID: 239703  Cd Length: 41  Bit Score: 37.25  E-value: 7.62e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 7705831  458 TVPSLTHLCRLEIrsslksERLRSDsyISQLPLPRSLHNYL 498
Cdd:cd03734   2 SARSLQHLCRLVI------NRLVTD--VDCLPLPRRMADYL 34
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 214-240 7.69e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 36.88  E-value: 7.69e-04
                          10        20
                  ....*....|....*....|....*...
gi 7705831    214 TPLFIAA-QEGHTKCVELLLSSGADPDL 240
Cdd:pfam00023   4 TPLHLAAgRRGNLEIVKLLLSKGADVNA 31
SOCS_ASB1 cd03720
SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a ...
 461-501 9.93e-04

SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239690  Cd Length: 42  Bit Score: 37.01  E-value: 9.93e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 7705831  461 SLTHLCRLEIRSSLKSERLrsdSYISQLPLPRSLHNYLLYE 501
Cdd:cd03720   5 SLLSLCRIAVRRALGKQRL---SLICSLPLPDPIKKFLLHE 42
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 78-107 1.81e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 35.70  E-value: 1.81e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 7705831     78 EGFCALHLAASQGHWKIVQILLEAGADPNA 107
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADINA 30
SOCS_ASB8 cd03727
SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a ...
 460-499 1.95e-03

SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB8 is highly transcribed in skeletal muscle and in lung carcinoma cell lines. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239697  Cd Length: 43  Bit Score: 35.97  E-value: 1.95e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 7705831  460 PSLTHLCRLEIRSSLkSERLRSDSyISQLPLPRSLHNYLL 499
Cdd:cd03727   4 GTLKALARYAVRRSL-GVQYLPEA-VKQLPLPRSVKEYLL 41
PHA02859 PHA02859
ankyrin repeat protein; Provisional
 114-185 2.31e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165195 [Multi-domain]  Cd Length: 209  Bit Score: 39.42  E-value: 2.31e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 7705831   114 TPLFLAVENGQI--DVLRLLLQHGANVNGSHSMCGWNSLHQ-ASFQENA--EIIKLLLRKGANKECQDDFGITPLFV 185
Cdd:PHA02859  53 TPIFSCLEKDKVnvEILKFLIENGADVNFKTRDNNLSALHHyLSFNKNVepEILKILIDSGSSITEEDEDGKNLLHM 129
Ank_4 pfam13637
Ankyrin repeats (many copies);
46-99 3.00e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 36.10  E-value: 3.00e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 7705831     46 PIHEAAYHNSVECLQMLINADSSENyikMKTFEGFCALHLAASQGHWKIVQILL 99
Cdd:pfam13637   4 ALHAAAASGHLELLRLLLEKGADIN---AVDGNGETALHFAASNGNVEVLKLLL 54
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 188-240 3.13e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 40.43  E-value: 3.13e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 7705831   188 QYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDL 240
Cdd:PHA02876 154 QQDELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNI 206
PHA02736 PHA02736
Viral ankyrin protein; Provisional
 125-203 3.15e-03

Viral ankyrin protein; Provisional


Pssm-ID: 165103 [Multi-domain]  Cd Length: 154  Bit Score: 38.32  E-value: 3.15e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831   125 IDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRK-GANKECQDDFGITPLFVAAQYGKLESLSILISSGA 203
Cdd:PHA02736  71 QEKLKLLMEWGADINGKERVFGNTPLHIAVYTQNYELATWLCNQpGVNMEILNYAFKTPYYVACERHDAKMMNILRAKGA 150
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 179-207 3.81e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.87  E-value: 3.81e-03
                           10        20
                   ....*....|....*....|....*....
gi 7705831     179 GITPLFVAAQYGKLESLSILISSGANVNC 207
Cdd:smart00248   2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 220-301 5.04e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 39.50  E-value: 5.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831   220 AQEGHTKCVELLLSSGADPDlyCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEIL 299
Cdd:PTZ00322  90 AASGDAVGARILLTGGADPN--CRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLL 167


                 ..
gi 7705831   300 LR 301
Cdd:PTZ00322 168 SR 169
SOCS_ASB6 cd03725
SOCS (suppressors of cytokine signaling) box of ASB6-like proteins. ASB family members have a ...
 460-501 8.35e-03

SOCS (suppressors of cytokine signaling) box of ASB6-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB6 interacts with the adaptor protein APS and recruits elongin B/C to the insulin receptor signaling complex. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239695  Cd Length: 44  Bit Score: 34.34  E-value: 8.35e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 7705831  460 PSLTHLCRLEIRSSLKSERLrsDSYISQLPLPRSLHNYLLYE 501
Cdd:cd03725   4 PPLKHLCRVFIRLCLRPWPV--DVKVKALPLPDRLKWYLLPE 43
PHA02791 PHA02791
ankyrin-like protein; Provisional
 39-168 8.65e-03

ankyrin-like protein; Provisional


Pssm-ID: 165154 [Multi-domain]  Cd Length: 284  Bit Score: 38.10  E-value: 8.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831    39 ADNRGWMPIHEAAYHNSVECLQMLINADSSENYIkmktfEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFL 118
Cdd:PHA02791  26 ADVHGHSALYYAIADNNVRLVCTLLNAGALKNLL-----ENEFPLHQAATLEDTKIVKILLFSGMDDSQFDDKGNTALYY 100

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 7705831   119 AVENGQIDVLRLLLQHGANVNgSHSMCGW-NSLHQASFQENAEIIKLLLRK 168
Cdd:PHA02791 101 AVDSGNMQTVKLFVKKNWRLM-FYGKTGWkTSFYHAVMLNDVSIVSYFLSE 150
PHA02946 PHA02946
ankyin-like protein; Provisional
 106-217 9.96e-03

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 38.50  E-value: 9.96e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705831   106 NATTLEETTPLFLAVENGQIDVLRLLLQH---GANVNGSHSMCGWNSLHQASFQEnaeiiklLLRKGANKECQDDFGITP 182
Cdd:PHA02946   3 NIMSAEYYLSLYAKYNSKNLDVFRNMLQAiepSGNYHILHAYCGIKGLDERFVEE-------LLHRGYSPNETDDDGNYP 75

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 7705831   183 LFVAAQYGKLESLSILISSGANVNCQALDKATPLF 217
Cdd:PHA02946  76 LHIASKINNNRIVAMLLTHGADPNACDKQHKTPLY 110
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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