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Conserved domains on  [gi|330864783|ref|NP_057461|]
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A-kinase anchoring protein 7 isoform gamma [Homo sapiens]

Protein Classification

AKAP7_NLS and AKAP7_RIRII_bdg domain-containing protein( domain architecture ID 12106243)

AKAP7_NLS and AKAP7_RIRII_bdg domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AKAP7_NLS pfam10469
AKAP7 2'5' RNA ligase-like domain; AKAP7_NLS is the N-terminal domain of the cyclic ...
 85-283 2.07e-65

AKAP7 2'5' RNA ligase-like domain; AKAP7_NLS is the N-terminal domain of the cyclic AMP-dependent protein kinase A, PKA, anchor protein AKAP7. This protein anchors PKA for its role in regulating PKA-mediated gene transcription in both somatic cells and oocytes. AKAP7_NLS carries the nuclear localization signal (NLS) KKRKK, that indicates the cellular destiny of this anchor protein. Binding to the regulatory subunits RI and RII of PKA is mediated via the family AKAP7_RIRII_bdg. at the C-terminus. This family represents a region that contains two 2'5' RNA ligase like domains pfam02834. Presumably this domain carried out some as yet unknown enzymatic function.


:

Pssm-ID: 402204 [Multi-domain]  Cd Length: 207  Bit Score: 205.58  E-value: 2.07e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330864783   85 PNYFLSIPITNKEIIKGIKILQNAIIQQDERLAKAM-VSDGSFHITLLVMQLLNEDEVNIGIDALLELKPFIEELLQGKH 163
Cdd:pfam10469   1 PTHFLSIPLNSPELRKRLEEFQESVLKQLPGLDESLfIPPEKLHITLLVLVLLDDEEVARAKEALRECREEIKDILNGNP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330864783  164 LTLPFQGIGTFG-----NQVGFVKLAEGDHVNSLLEIAETANRTFQEKGILVGESRS-FKPHLTFMKLSKSPWLRKNGVK 237
Cdd:pfam10469  81 LSLRFKGLETFNddpsaVRVLYAKVEEDDHSPKLQELADRIIRRFQEAGLLVKENNSrVKLHMTLMNTRYRKKKYAKSKE 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 330864783  238 KIDP-DLYEKFISHRFGEEILYRIDLCSMLKKKQSNGYYHCESSIVI 283
Cdd:pfam10469 161 SFDArEILDEFKDFDFGTQKVSELHLCSMGSSDESDGFYHVEASVKL 207
AKAP7_RIRII_bdg pfam10470
PKA-RI-RII subunit binding domain of A-kinase anchor protein; AKAP7_RIRII_bdg is the ...
 290-345 5.46e-30

PKA-RI-RII subunit binding domain of A-kinase anchor protein; AKAP7_RIRII_bdg is the C-terminal domain of the cyclic AMP-dependent protein kinase A, PKA, anchor protein AKAP7. This protein anchors PKA, for its role in regulating PKA-mediated gene transcription in both somatic cells and oocytes, by binding to its regulatory subunits, RI and RII, hence being known as a dual-specific AKAP. The 25 crucial amino acids of RII-binding domains in general form structurally conserved amphipathic helices with unrelated sequences; hydrophobic amino acid residues form the backbone of the interaction and hydrogen bond- and salt-bridge-forming amino acid residues increase the affinity of the interaction. The N-terminus, of family AKAP7_NLS, carries the nuclear localization signal.


:

Pssm-ID: 463101  Cd Length: 56  Bit Score: 108.89  E-value: 5.46e-30
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 330864783  290 EPDDAELVRLSKRLVENAVLKAVQQYLEETQNKNKPGEGSSVKTEAADQNGNDNEN 345
Cdd:pfam10470   1 EPDDAELVRLSKRLVENAVLKAVQQYLEETQNKNRPGDGSSVKAEEADRGGNGSDN 56
 
Name Accession Description Interval E-value
AKAP7_NLS pfam10469
AKAP7 2'5' RNA ligase-like domain; AKAP7_NLS is the N-terminal domain of the cyclic ...
 85-283 2.07e-65

AKAP7 2'5' RNA ligase-like domain; AKAP7_NLS is the N-terminal domain of the cyclic AMP-dependent protein kinase A, PKA, anchor protein AKAP7. This protein anchors PKA for its role in regulating PKA-mediated gene transcription in both somatic cells and oocytes. AKAP7_NLS carries the nuclear localization signal (NLS) KKRKK, that indicates the cellular destiny of this anchor protein. Binding to the regulatory subunits RI and RII of PKA is mediated via the family AKAP7_RIRII_bdg. at the C-terminus. This family represents a region that contains two 2'5' RNA ligase like domains pfam02834. Presumably this domain carried out some as yet unknown enzymatic function.


Pssm-ID: 402204 [Multi-domain]  Cd Length: 207  Bit Score: 205.58  E-value: 2.07e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330864783   85 PNYFLSIPITNKEIIKGIKILQNAIIQQDERLAKAM-VSDGSFHITLLVMQLLNEDEVNIGIDALLELKPFIEELLQGKH 163
Cdd:pfam10469   1 PTHFLSIPLNSPELRKRLEEFQESVLKQLPGLDESLfIPPEKLHITLLVLVLLDDEEVARAKEALRECREEIKDILNGNP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330864783  164 LTLPFQGIGTFG-----NQVGFVKLAEGDHVNSLLEIAETANRTFQEKGILVGESRS-FKPHLTFMKLSKSPWLRKNGVK 237
Cdd:pfam10469  81 LSLRFKGLETFNddpsaVRVLYAKVEEDDHSPKLQELADRIIRRFQEAGLLVKENNSrVKLHMTLMNTRYRKKKYAKSKE 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 330864783  238 KIDP-DLYEKFISHRFGEEILYRIDLCSMLKKKQSNGYYHCESSIVI 283
Cdd:pfam10469 161 SFDArEILDEFKDFDFGTQKVSELHLCSMGSSDESDGFYHVEASVKL 207
AKAP7_RIRII_bdg pfam10470
PKA-RI-RII subunit binding domain of A-kinase anchor protein; AKAP7_RIRII_bdg is the ...
 290-345 5.46e-30

PKA-RI-RII subunit binding domain of A-kinase anchor protein; AKAP7_RIRII_bdg is the C-terminal domain of the cyclic AMP-dependent protein kinase A, PKA, anchor protein AKAP7. This protein anchors PKA, for its role in regulating PKA-mediated gene transcription in both somatic cells and oocytes, by binding to its regulatory subunits, RI and RII, hence being known as a dual-specific AKAP. The 25 crucial amino acids of RII-binding domains in general form structurally conserved amphipathic helices with unrelated sequences; hydrophobic amino acid residues form the backbone of the interaction and hydrogen bond- and salt-bridge-forming amino acid residues increase the affinity of the interaction. The N-terminus, of family AKAP7_NLS, carries the nuclear localization signal.


Pssm-ID: 463101  Cd Length: 56  Bit Score: 108.89  E-value: 5.46e-30
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 330864783  290 EPDDAELVRLSKRLVENAVLKAVQQYLEETQNKNKPGEGSSVKTEAADQNGNDNEN 345
Cdd:pfam10470   1 EPDDAELVRLSKRLVENAVLKAVQQYLEETQNKNRPGDGSSVKAEEADRGGNGSDN 56
ThpR COG1514
RNA 2',3'-cyclic phosphodiesterase (2'-5' RNA ligase) [Translation, ribosomal structure and ...
 87-221 1.85e-06

RNA 2',3'-cyclic phosphodiesterase (2'-5' RNA ligase) [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441123 [Multi-domain]  Cd Length: 181  Bit Score: 47.72  E-value: 1.85e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330864783  87 YFLSIPItNKEIIKGIKILQNAIiqqDERLAKAMVSDGSFHITLLVMQLLNEDEVNIGIDAL----LELKPFieellqgk 162
Cdd:COG1514    3 LFIALPP-PEELREALAALRARL---KAAPGGRWVRPENLHLTLAFLGEVDEERLEALAEALaraaAGAPPF-------- 70

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 330864783 163 hlTLPFQGIGTFGNQVG---FVKLAEGDhvnSLLEIAETANRTFQEKGILVgESRSFKPHLT 221
Cdd:COG1514   71 --ELRLDGLGAFPRPRPrvlWLGVEPSP---ELLALHRRLRAALARAGLPP-ERRPFVPHVT 126
PLN00108 PLN00108
unknown protein; Provisional
 87-281 9.20e-05

unknown protein; Provisional


Pssm-ID: 177724  Cd Length: 257  Bit Score: 43.52  E-value: 9.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330864783  87 YFLSIPIT-NKEIIKGIKILQNAIIQQDER--------LAKA------MVSDGSFHITLLVMQLLNEDEVNIGIDALLEL 151
Cdd:PLN00108  38 HFVSLPLAiYPDLKKNIEAFQNSVLGNNDKdplkfqstLAEMgieksiFVSPKTFHLTVVMLKLENNESVVKAQNILKSI 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330864783 152 KPFIEELLQGKHLTLPFQGIGTFG-----NQVGFVKLAEGDHVNSLLEIAETANRTFQEKGILVGESRS-FKPHLTFMKL 225
Cdd:PLN00108 118 CSNVRQALKDRPVFIRLRGLDCMNgsldkTRVLYAPVEEVGHEGRLLNACHVIIDAFENAGFAGKDAKSrLKLHATLMNA 197

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 330864783 226 SkspwLRKNGVKKIDP----DLYEKFISHRFGEEILYRIDLcSMLKKKQSNGYYHCESSI 281
Cdd:PLN00108 198 S----YRKDKSKKMDTfdarEIHKEFENKDWGTYLIREAHI-SQRYKYDPNGYFHCCASL 252
2_5_ligase TIGR02258
2'-5' RNA ligase; This protein family consists of bacterial and archaeal proteins with two ...
 87-228 9.41e-05

2'-5' RNA ligase; This protein family consists of bacterial and archaeal proteins with two tandem copies of Pfam domain pfam02834. Members for which activity has been measured perform a reversible, ATP-independent 2'-5'-ligation of what is presumably a non-phyiological substrate: half-tRNA splice intermediates from an intron-containing yeast tRNA. The physiological substrate(s) in prokaryotes may include small 2'-5'-link-containing oligonucleotides, perhaps with regulatory or biosynthetic roles. [Transcription, RNA processing]


Pssm-ID: 274058 [Multi-domain]  Cd Length: 179  Bit Score: 42.66  E-value: 9.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330864783   87 YFLSIPITNkEIIKGIKILQNAIIQQDErlAKAMVSDGSFHITLLVMQLLNEDEVNIGIDALLELK--PFieellqgkhl 164
Cdd:TIGR02258   3 LFIAIDLPP-EIREQLSRIQRKLKSPLD--GIKWVPPENLHITLKFLGEVDEEQVEELEDALAKIAepPF---------- 69

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 330864783  165 TLPFQGIGTFGNQ----VGFVKLAEGDHVNSLLEIAETAnrtFQEKGILVgESRSFKPHLTFMKLSKS 228
Cdd:TIGR02258  70 TLKLEGIGVFGNPkrprVLWAGVEQSEELTQLHADLERE---LAKLGFSK-EERPFTPHITLARKKSG 133
 
Name Accession Description Interval E-value
AKAP7_NLS pfam10469
AKAP7 2'5' RNA ligase-like domain; AKAP7_NLS is the N-terminal domain of the cyclic ...
 85-283 2.07e-65

AKAP7 2'5' RNA ligase-like domain; AKAP7_NLS is the N-terminal domain of the cyclic AMP-dependent protein kinase A, PKA, anchor protein AKAP7. This protein anchors PKA for its role in regulating PKA-mediated gene transcription in both somatic cells and oocytes. AKAP7_NLS carries the nuclear localization signal (NLS) KKRKK, that indicates the cellular destiny of this anchor protein. Binding to the regulatory subunits RI and RII of PKA is mediated via the family AKAP7_RIRII_bdg. at the C-terminus. This family represents a region that contains two 2'5' RNA ligase like domains pfam02834. Presumably this domain carried out some as yet unknown enzymatic function.


Pssm-ID: 402204 [Multi-domain]  Cd Length: 207  Bit Score: 205.58  E-value: 2.07e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330864783   85 PNYFLSIPITNKEIIKGIKILQNAIIQQDERLAKAM-VSDGSFHITLLVMQLLNEDEVNIGIDALLELKPFIEELLQGKH 163
Cdd:pfam10469   1 PTHFLSIPLNSPELRKRLEEFQESVLKQLPGLDESLfIPPEKLHITLLVLVLLDDEEVARAKEALRECREEIKDILNGNP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330864783  164 LTLPFQGIGTFG-----NQVGFVKLAEGDHVNSLLEIAETANRTFQEKGILVGESRS-FKPHLTFMKLSKSPWLRKNGVK 237
Cdd:pfam10469  81 LSLRFKGLETFNddpsaVRVLYAKVEEDDHSPKLQELADRIIRRFQEAGLLVKENNSrVKLHMTLMNTRYRKKKYAKSKE 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 330864783  238 KIDP-DLYEKFISHRFGEEILYRIDLCSMLKKKQSNGYYHCESSIVI 283
Cdd:pfam10469 161 SFDArEILDEFKDFDFGTQKVSELHLCSMGSSDESDGFYHVEASVKL 207
AKAP7_RIRII_bdg pfam10470
PKA-RI-RII subunit binding domain of A-kinase anchor protein; AKAP7_RIRII_bdg is the ...
 290-345 5.46e-30

PKA-RI-RII subunit binding domain of A-kinase anchor protein; AKAP7_RIRII_bdg is the C-terminal domain of the cyclic AMP-dependent protein kinase A, PKA, anchor protein AKAP7. This protein anchors PKA, for its role in regulating PKA-mediated gene transcription in both somatic cells and oocytes, by binding to its regulatory subunits, RI and RII, hence being known as a dual-specific AKAP. The 25 crucial amino acids of RII-binding domains in general form structurally conserved amphipathic helices with unrelated sequences; hydrophobic amino acid residues form the backbone of the interaction and hydrogen bond- and salt-bridge-forming amino acid residues increase the affinity of the interaction. The N-terminus, of family AKAP7_NLS, carries the nuclear localization signal.


Pssm-ID: 463101  Cd Length: 56  Bit Score: 108.89  E-value: 5.46e-30
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 330864783  290 EPDDAELVRLSKRLVENAVLKAVQQYLEETQNKNKPGEGSSVKTEAADQNGNDNEN 345
Cdd:pfam10470   1 EPDDAELVRLSKRLVENAVLKAVQQYLEETQNKNRPGDGSSVKAEEADRGGNGSDN 56
ThpR COG1514
RNA 2',3'-cyclic phosphodiesterase (2'-5' RNA ligase) [Translation, ribosomal structure and ...
 87-221 1.85e-06

RNA 2',3'-cyclic phosphodiesterase (2'-5' RNA ligase) [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441123 [Multi-domain]  Cd Length: 181  Bit Score: 47.72  E-value: 1.85e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330864783  87 YFLSIPItNKEIIKGIKILQNAIiqqDERLAKAMVSDGSFHITLLVMQLLNEDEVNIGIDAL----LELKPFieellqgk 162
Cdd:COG1514    3 LFIALPP-PEELREALAALRARL---KAAPGGRWVRPENLHLTLAFLGEVDEERLEALAEALaraaAGAPPF-------- 70

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 330864783 163 hlTLPFQGIGTFGNQVG---FVKLAEGDhvnSLLEIAETANRTFQEKGILVgESRSFKPHLT 221
Cdd:COG1514   71 --ELRLDGLGAFPRPRPrvlWLGVEPSP---ELLALHRRLRAALARAGLPP-ERRPFVPHVT 126
PLN00108 PLN00108
unknown protein; Provisional
 87-281 9.20e-05

unknown protein; Provisional


Pssm-ID: 177724  Cd Length: 257  Bit Score: 43.52  E-value: 9.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330864783  87 YFLSIPIT-NKEIIKGIKILQNAIIQQDER--------LAKA------MVSDGSFHITLLVMQLLNEDEVNIGIDALLEL 151
Cdd:PLN00108  38 HFVSLPLAiYPDLKKNIEAFQNSVLGNNDKdplkfqstLAEMgieksiFVSPKTFHLTVVMLKLENNESVVKAQNILKSI 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330864783 152 KPFIEELLQGKHLTLPFQGIGTFG-----NQVGFVKLAEGDHVNSLLEIAETANRTFQEKGILVGESRS-FKPHLTFMKL 225
Cdd:PLN00108 118 CSNVRQALKDRPVFIRLRGLDCMNgsldkTRVLYAPVEEVGHEGRLLNACHVIIDAFENAGFAGKDAKSrLKLHATLMNA 197

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 330864783 226 SkspwLRKNGVKKIDP----DLYEKFISHRFGEEILYRIDLcSMLKKKQSNGYYHCESSI 281
Cdd:PLN00108 198 S----YRKDKSKKMDTfdarEIHKEFENKDWGTYLIREAHI-SQRYKYDPNGYFHCCASL 252
2_5_ligase TIGR02258
2'-5' RNA ligase; This protein family consists of bacterial and archaeal proteins with two ...
 87-228 9.41e-05

2'-5' RNA ligase; This protein family consists of bacterial and archaeal proteins with two tandem copies of Pfam domain pfam02834. Members for which activity has been measured perform a reversible, ATP-independent 2'-5'-ligation of what is presumably a non-phyiological substrate: half-tRNA splice intermediates from an intron-containing yeast tRNA. The physiological substrate(s) in prokaryotes may include small 2'-5'-link-containing oligonucleotides, perhaps with regulatory or biosynthetic roles. [Transcription, RNA processing]


Pssm-ID: 274058 [Multi-domain]  Cd Length: 179  Bit Score: 42.66  E-value: 9.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330864783   87 YFLSIPITNkEIIKGIKILQNAIIQQDErlAKAMVSDGSFHITLLVMQLLNEDEVNIGIDALLELK--PFieellqgkhl 164
Cdd:TIGR02258   3 LFIAIDLPP-EIREQLSRIQRKLKSPLD--GIKWVPPENLHITLKFLGEVDEEQVEELEDALAKIAepPF---------- 69

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 330864783  165 TLPFQGIGTFGNQ----VGFVKLAEGDHVNSLLEIAETAnrtFQEKGILVgESRSFKPHLTFMKLSKS 228
Cdd:TIGR02258  70 TLKLEGIGVFGNPkrprVLWAGVEQSEELTQLHADLERE---LAKLGFSK-EERPFTPHITLARKKSG 133
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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