![](files/infoQ.gif)
A-kinase anchoring protein 7 isoform gamma [Homo sapiens]
AKAP7_NLS and AKAP7_RIRII_bdg domain-containing protein( domain architecture ID 12106243)
AKAP7_NLS and AKAP7_RIRII_bdg domain-containing protein
List of domain hits
![](files/help.png)
Name | Accession | Description | Interval | E-value | ||||
AKAP7_NLS | pfam10469 | AKAP7 2'5' RNA ligase-like domain; AKAP7_NLS is the N-terminal domain of the cyclic ... |
85-283 | 2.07e-65 | ||||
AKAP7 2'5' RNA ligase-like domain; AKAP7_NLS is the N-terminal domain of the cyclic AMP-dependent protein kinase A, PKA, anchor protein AKAP7. This protein anchors PKA for its role in regulating PKA-mediated gene transcription in both somatic cells and oocytes. AKAP7_NLS carries the nuclear localization signal (NLS) KKRKK, that indicates the cellular destiny of this anchor protein. Binding to the regulatory subunits RI and RII of PKA is mediated via the family AKAP7_RIRII_bdg. at the C-terminus. This family represents a region that contains two 2'5' RNA ligase like domains pfam02834. Presumably this domain carried out some as yet unknown enzymatic function. : Pssm-ID: 402204 [Multi-domain] Cd Length: 207 Bit Score: 205.58 E-value: 2.07e-65
|
||||||||
AKAP7_RIRII_bdg | pfam10470 | PKA-RI-RII subunit binding domain of A-kinase anchor protein; AKAP7_RIRII_bdg is the ... |
290-345 | 5.46e-30 | ||||
PKA-RI-RII subunit binding domain of A-kinase anchor protein; AKAP7_RIRII_bdg is the C-terminal domain of the cyclic AMP-dependent protein kinase A, PKA, anchor protein AKAP7. This protein anchors PKA, for its role in regulating PKA-mediated gene transcription in both somatic cells and oocytes, by binding to its regulatory subunits, RI and RII, hence being known as a dual-specific AKAP. The 25 crucial amino acids of RII-binding domains in general form structurally conserved amphipathic helices with unrelated sequences; hydrophobic amino acid residues form the backbone of the interaction and hydrogen bond- and salt-bridge-forming amino acid residues increase the affinity of the interaction. The N-terminus, of family AKAP7_NLS, carries the nuclear localization signal. : Pssm-ID: 463101 Cd Length: 56 Bit Score: 108.89 E-value: 5.46e-30
|
||||||||
Name | Accession | Description | Interval | E-value | ||||
AKAP7_NLS | pfam10469 | AKAP7 2'5' RNA ligase-like domain; AKAP7_NLS is the N-terminal domain of the cyclic ... |
85-283 | 2.07e-65 | ||||
AKAP7 2'5' RNA ligase-like domain; AKAP7_NLS is the N-terminal domain of the cyclic AMP-dependent protein kinase A, PKA, anchor protein AKAP7. This protein anchors PKA for its role in regulating PKA-mediated gene transcription in both somatic cells and oocytes. AKAP7_NLS carries the nuclear localization signal (NLS) KKRKK, that indicates the cellular destiny of this anchor protein. Binding to the regulatory subunits RI and RII of PKA is mediated via the family AKAP7_RIRII_bdg. at the C-terminus. This family represents a region that contains two 2'5' RNA ligase like domains pfam02834. Presumably this domain carried out some as yet unknown enzymatic function. Pssm-ID: 402204 [Multi-domain] Cd Length: 207 Bit Score: 205.58 E-value: 2.07e-65
|
||||||||
AKAP7_RIRII_bdg | pfam10470 | PKA-RI-RII subunit binding domain of A-kinase anchor protein; AKAP7_RIRII_bdg is the ... |
290-345 | 5.46e-30 | ||||
PKA-RI-RII subunit binding domain of A-kinase anchor protein; AKAP7_RIRII_bdg is the C-terminal domain of the cyclic AMP-dependent protein kinase A, PKA, anchor protein AKAP7. This protein anchors PKA, for its role in regulating PKA-mediated gene transcription in both somatic cells and oocytes, by binding to its regulatory subunits, RI and RII, hence being known as a dual-specific AKAP. The 25 crucial amino acids of RII-binding domains in general form structurally conserved amphipathic helices with unrelated sequences; hydrophobic amino acid residues form the backbone of the interaction and hydrogen bond- and salt-bridge-forming amino acid residues increase the affinity of the interaction. The N-terminus, of family AKAP7_NLS, carries the nuclear localization signal. Pssm-ID: 463101 Cd Length: 56 Bit Score: 108.89 E-value: 5.46e-30
|
||||||||
ThpR | COG1514 | RNA 2',3'-cyclic phosphodiesterase (2'-5' RNA ligase) [Translation, ribosomal structure and ... |
87-221 | 1.85e-06 | ||||
RNA 2',3'-cyclic phosphodiesterase (2'-5' RNA ligase) [Translation, ribosomal structure and biogenesis]; Pssm-ID: 441123 [Multi-domain] Cd Length: 181 Bit Score: 47.72 E-value: 1.85e-06
|
||||||||
PLN00108 | PLN00108 | unknown protein; Provisional |
87-281 | 9.20e-05 | ||||
unknown protein; Provisional Pssm-ID: 177724 Cd Length: 257 Bit Score: 43.52 E-value: 9.20e-05
|
||||||||
2_5_ligase | TIGR02258 | 2'-5' RNA ligase; This protein family consists of bacterial and archaeal proteins with two ... |
87-228 | 9.41e-05 | ||||
2'-5' RNA ligase; This protein family consists of bacterial and archaeal proteins with two tandem copies of Pfam domain pfam02834. Members for which activity has been measured perform a reversible, ATP-independent 2'-5'-ligation of what is presumably a non-phyiological substrate: half-tRNA splice intermediates from an intron-containing yeast tRNA. The physiological substrate(s) in prokaryotes may include small 2'-5'-link-containing oligonucleotides, perhaps with regulatory or biosynthetic roles. [Transcription, RNA processing] Pssm-ID: 274058 [Multi-domain] Cd Length: 179 Bit Score: 42.66 E-value: 9.41e-05
|
||||||||
Name | Accession | Description | Interval | E-value | ||||
AKAP7_NLS | pfam10469 | AKAP7 2'5' RNA ligase-like domain; AKAP7_NLS is the N-terminal domain of the cyclic ... |
85-283 | 2.07e-65 | ||||
AKAP7 2'5' RNA ligase-like domain; AKAP7_NLS is the N-terminal domain of the cyclic AMP-dependent protein kinase A, PKA, anchor protein AKAP7. This protein anchors PKA for its role in regulating PKA-mediated gene transcription in both somatic cells and oocytes. AKAP7_NLS carries the nuclear localization signal (NLS) KKRKK, that indicates the cellular destiny of this anchor protein. Binding to the regulatory subunits RI and RII of PKA is mediated via the family AKAP7_RIRII_bdg. at the C-terminus. This family represents a region that contains two 2'5' RNA ligase like domains pfam02834. Presumably this domain carried out some as yet unknown enzymatic function. Pssm-ID: 402204 [Multi-domain] Cd Length: 207 Bit Score: 205.58 E-value: 2.07e-65
|
||||||||
AKAP7_RIRII_bdg | pfam10470 | PKA-RI-RII subunit binding domain of A-kinase anchor protein; AKAP7_RIRII_bdg is the ... |
290-345 | 5.46e-30 | ||||
PKA-RI-RII subunit binding domain of A-kinase anchor protein; AKAP7_RIRII_bdg is the C-terminal domain of the cyclic AMP-dependent protein kinase A, PKA, anchor protein AKAP7. This protein anchors PKA, for its role in regulating PKA-mediated gene transcription in both somatic cells and oocytes, by binding to its regulatory subunits, RI and RII, hence being known as a dual-specific AKAP. The 25 crucial amino acids of RII-binding domains in general form structurally conserved amphipathic helices with unrelated sequences; hydrophobic amino acid residues form the backbone of the interaction and hydrogen bond- and salt-bridge-forming amino acid residues increase the affinity of the interaction. The N-terminus, of family AKAP7_NLS, carries the nuclear localization signal. Pssm-ID: 463101 Cd Length: 56 Bit Score: 108.89 E-value: 5.46e-30
|
||||||||
ThpR | COG1514 | RNA 2',3'-cyclic phosphodiesterase (2'-5' RNA ligase) [Translation, ribosomal structure and ... |
87-221 | 1.85e-06 | ||||
RNA 2',3'-cyclic phosphodiesterase (2'-5' RNA ligase) [Translation, ribosomal structure and biogenesis]; Pssm-ID: 441123 [Multi-domain] Cd Length: 181 Bit Score: 47.72 E-value: 1.85e-06
|
||||||||
PLN00108 | PLN00108 | unknown protein; Provisional |
87-281 | 9.20e-05 | ||||
unknown protein; Provisional Pssm-ID: 177724 Cd Length: 257 Bit Score: 43.52 E-value: 9.20e-05
|
||||||||
2_5_ligase | TIGR02258 | 2'-5' RNA ligase; This protein family consists of bacterial and archaeal proteins with two ... |
87-228 | 9.41e-05 | ||||
2'-5' RNA ligase; This protein family consists of bacterial and archaeal proteins with two tandem copies of Pfam domain pfam02834. Members for which activity has been measured perform a reversible, ATP-independent 2'-5'-ligation of what is presumably a non-phyiological substrate: half-tRNA splice intermediates from an intron-containing yeast tRNA. The physiological substrate(s) in prokaryotes may include small 2'-5'-link-containing oligonucleotides, perhaps with regulatory or biosynthetic roles. [Transcription, RNA processing] Pssm-ID: 274058 [Multi-domain] Cd Length: 179 Bit Score: 42.66 E-value: 9.41e-05
|
||||||||
Blast search parameters | ||||
|