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Conserved domains on  [gi|54607137|ref|NP_057472|]
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T-cell receptor-associated transmembrane adapter 1 isoform 1 [Homo sapiens]

Protein Classification

SIT domain-containing protein( domain architecture ID 10633987)

SIT domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SIT pfam15330
SHP2-interacting transmembrane adaptor protein, SIT; SIT, or SHP2-interacting transmembrane ...
 23-120 2.75e-36

SHP2-interacting transmembrane adaptor protein, SIT; SIT, or SHP2-interacting transmembrane adaptor protein, is a disulfide-linked dimer that regulates human T Cell activation.


:

Pssm-ID: 464650  Cd Length: 114  Bit Score: 122.49  E-value: 2.75e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54607137    23 VISLIFNISHYVEKQRQDKMYSYSSDHTRVDEYY---IEDTPIYGNLDDMI----SEPMDENCYEQMKARPEKSVNKMQe 95
Cdd:pfam15330  12 LLLVAASLLAWRMMKRQKKAAGYSPEQVIPREYYlqpIEGDLCYANLTLQQtgtsPGSSDEKAYEQMSSSAQRSQNEVE- 90

                          90       100
                  ....*....|....*....|....*
gi 54607137    96 aTPSAQATNETQMCYASLDHSVKGK 120
Cdd:pfam15330  91 -YVTMAPFPREEISYASLSLDVLDQ 114
 
Name Accession Description Interval E-value
SIT pfam15330
SHP2-interacting transmembrane adaptor protein, SIT; SIT, or SHP2-interacting transmembrane ...
 23-120 2.75e-36

SHP2-interacting transmembrane adaptor protein, SIT; SIT, or SHP2-interacting transmembrane adaptor protein, is a disulfide-linked dimer that regulates human T Cell activation.


Pssm-ID: 464650  Cd Length: 114  Bit Score: 122.49  E-value: 2.75e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54607137    23 VISLIFNISHYVEKQRQDKMYSYSSDHTRVDEYY---IEDTPIYGNLDDMI----SEPMDENCYEQMKARPEKSVNKMQe 95
Cdd:pfam15330  12 LLLVAASLLAWRMMKRQKKAAGYSPEQVIPREYYlqpIEGDLCYANLTLQQtgtsPGSSDEKAYEQMSSSAQRSQNEVE- 90

                          90       100
                  ....*....|....*....|....*
gi 54607137    96 aTPSAQATNETQMCYASLDHSVKGK 120
Cdd:pfam15330  91 -YVTMAPFPREEISYASLSLDVLDQ 114
 
Name Accession Description Interval E-value
SIT pfam15330
SHP2-interacting transmembrane adaptor protein, SIT; SIT, or SHP2-interacting transmembrane ...
 23-120 2.75e-36

SHP2-interacting transmembrane adaptor protein, SIT; SIT, or SHP2-interacting transmembrane adaptor protein, is a disulfide-linked dimer that regulates human T Cell activation.


Pssm-ID: 464650  Cd Length: 114  Bit Score: 122.49  E-value: 2.75e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54607137    23 VISLIFNISHYVEKQRQDKMYSYSSDHTRVDEYY---IEDTPIYGNLDDMI----SEPMDENCYEQMKARPEKSVNKMQe 95
Cdd:pfam15330  12 LLLVAASLLAWRMMKRQKKAAGYSPEQVIPREYYlqpIEGDLCYANLTLQQtgtsPGSSDEKAYEQMSSSAQRSQNEVE- 90

                          90       100
                  ....*....|....*....|....*
gi 54607137    96 aTPSAQATNETQMCYASLDHSVKGK 120
Cdd:pfam15330  91 -YVTMAPFPREEISYASLSLDVLDQ 114
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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