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Conserved domains on  [gi|7706093|ref|NP_057646|]
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toll-like receptor 7 precursor [Homo sapiens]

Protein Classification

TIR domain-containing protein; TIR domain-containing protein; toll/interleukin-1 receptor domain-containing protein; TIR domain-containing protein; toll/interleukin-1 receptor domain-containing protein; TIR domain-containing protein; toll/interleukin-1 receptor domain-containing protein; toll/interleukin-1 receptor domain-containing protein; toll/interleukin-1 receptor domain-containing protein; TIR domain-containing protein; toll/interleukin-1 receptor domain-containing protein; TIR domain-containing protein; toll/interleukin-1 receptor domain-containing protein; TIR domain-containing protein; toll/interleukin-1 receptor domain-containing protein; toll/interleukin-1 receptor domain-containing protein; toll/interleukin-1 receptor domain-containing protein; TIR domain-containing protein; toll/interleukin-1 receptor domain-containing protein; toll/interleukin-1 receptor domain-containing protein; TIR domain-containing protein; toll/interleukin-1 receptor domain-containing protein; toll/interleukin-1 receptor domain-containing protein; TIR domain-containing protein; toll/interleukin-1 receptor domain-containing protein; toll/interleukin-1 receptor domain-containing protein; toll/interleukin-1 receptor domain-containing protein; toll/interleukin-1 receptor domain-containing protein; toll/interleukin-1 receptor domain-containing protein; TIR domain-containing protein; toll/interleukin-1 receptor domain-containing protein; TIR domain-containing protein; toll/interleukin-1 receptor domain-containing protein; TIR domain-containing protein; toll/interleukin-1 receptor domain-containing protein; toll/interleukin-1 receptor domain-containing protein; toll/interleukin-1 receptor domain-containing protein; TIR domain-containing protein; toll/interleukin-1 receptor domain-containing protein; TIR domain-containing protein; toll/interleukin-1 receptor domain-containing protein; toll/interleukin-1 receptor domain-containing protein; toll/interleukin-1 receptor domain-containing protein; TIR domain-containing protein; toll/interleukin-1 receptor domain-containing protein; toll/interleukin-1 receptor domain-containing protein; toll/interleukin-1 receptor domain-containing protein; TIR domain-containing protein; toll/interleukin-1 receptor domain-containing protein; toll/interleukin-1 receptor domain-containing protein; TIR domain-containing protein; toll/interleukin-1 receptor domain-containing protein; toll/interleukin-1 receptor domain-containing protein; TIR domain-containing protein; toll/interleukin-1 receptor domain-containing protein; toll/interleukin-1 receptor domain-containing protein; toll/interleukin-1 receptor domain-containing protein; toll/interleukin-1 receptor domain-containing protein; toll/interleukin-1 receptor domain-containing protein; TIR domain-containing protein; toll/interleukin-1 receptor domain-containing protein; toll/interleukin-1 receptor domain-containing protein; TIR domain-containing protein; toll/interleukin-1 receptor domain-containing protein; toll/interleukin-1 receptor domain-containing protein; TIR domain-containing protein; toll/interleukin-1 receptor domain-containing protein; toll/interleukin-1 receptor domain-containing protein; toll/interleukin-1 receptor domain-containing protein; TIR domain-containing protein; toll/interleukin-1 receptor domain-containing protein; toll/interleukin-1 receptor domain-containing protein; TIR domain-containing protein; toll/interleukin-1 receptor domain-containing protein; toll/interleukin-1 receptor domain-containing protein; toll/interleukin-1 receptor domain-containing protein; toll/interleukin-1 receptor domain-containing protein; toll/interleukin-1 receptor domain-containing protein( domain architecture ID 13597834)

toll/interleukin-1 receptor (TIR) domain-containing protein with leucine-rich repeats similar to Ctenopharyngodon idella toll-like receptor 21; the TIR domain is responsible for signal transduction in all toll-like receptors (TLR); toll/interleukin-1 receptor (TIR) domain-containing protein with leucine-rich repeats similar to Cyprinus carpio toll-like receptor 20; the TIR domain is responsible for signal transduction in all toll-like receptors (TLR); toll/interleukin-1 receptor (TIR) domain-containing protein with leucine-rich repeats similar to Gallus gallus toll-like receptor 2; the TIR domain is responsible for signal transduction in all toll-like receptors (TLR); toll/interleukin-1 receptor (TIR) domain-containing protein with leucine-rich repeats similar to Ctenopharyngodon idella toll-like receptor 21; the TIR domain is responsible for signal transduction in all toll-like receptors (TLR); toll/interleukin-1 receptor (TIR) domain-containing protein with leucine-rich repeats similar to Cyprinus carpio toll-like receptor 20; the TIR domain is responsible for signal transduction in all toll-like receptors (TLR); toll/interleukin-1 receptor (TIR) domain-containing protein with leucine-rich repeats similar to Gallus gallus toll-like receptor 2; the TIR domain is responsible for signal transduction in all toll-like receptors (TLR); toll/interleukin-1 receptor (TIR) domain-containing protein with leucine-rich repeats similar to Ctenopharyngodon idella toll-like receptor 21; the TIR domain is responsible for signal transduction in all toll-like receptors (TLR); toll/interleukin-1 receptor (TIR) domain-containing protein with leucine-rich repeats similar to Cyprinus carpio toll-like receptor 20; the TIR domain is responsible for signal transduction in all toll-like receptors (TLR); toll/interleukin-1 receptor (TIR) domain-containing protein with leucine-rich repeats similar to toll-like receptor 4; the TIR domain is responsible for signal transduction in all toll-like receptors (TLR); toll/interleukin-1 receptor (TIR) domain-containing protein with leucine-rich repeats such as Rattus norvegicus toll-like receptor 4; the TIR domain is responsible for signal transduction in all toll-like receptors (TLR); toll/interleukin-1 receptor (TIR) domain-containing protein with leucine-rich repeats; the TIR domain is responsible for signal transduction in all toll-like receptors (TLR); toll/interleukin-1 receptor (TIR) domain-containing protein with leucine-rich repeats similar to Ctenopharyngodon idella toll-like receptor 21; the TIR domain is responsible for signal transduction in all toll-like receptors (TLR); toll/interleukin-1 receptor (TIR) domain-containing protein with leucine-rich repeats similar to Cyprinus carpio toll-like receptor 20; the TIR domain is responsible for signal transduction in all toll-like receptors (TLR); toll/interleukin-1 receptor (TIR) domain-containing protein with leucine-rich repeats; the TIR domain is responsible for signal transduction in all toll-like receptors (TLR); toll/interleukin-1 receptor (TIR) domain-containing protein with leucine-rich repeats similar to Ctenopharyngodon idella toll-like receptor 21; the TIR domain is responsible for signal transduction in all toll-like receptors (TLR); toll/interleukin-1 receptor (TIR) domain-containing protein with leucine-rich repeats similar to Gallus gallus toll-like receptor 2 type-1; the TIR domain is responsible for signal transduction in all toll-like receptors (TLR); toll/interleukin-1 receptor (TIR) domain-containing protein with leucine-rich repeats such as Rattus norvegicus toll-like receptor 4; the TIR domain is responsible for signal transduction in all toll-like receptors (TLR); toll/interleukin-1 receptor (TIR) domain-containing protein with leucine-rich repeats similar to Ctenopharyngodon idella toll-like receptor 21; the TIR domain is responsible for signal transduction in all toll-like receptors (TLR); toll/interleukin-1 receptor (TIR) domain-containing protein with leucine-rich repeats such as Rattus norvegicus toll-like receptor 4; the TIR domain is responsible for signal transduction in all toll-like receptors (TLR); toll/interleukin-1 receptor (TIR) domain-containing protein with leucine-rich repeats similar to Cyprinus carpio toll-like receptor 20; the TIR domain is responsible for signal transduction in all toll-like receptors (TLR); toll/interleukin-1 receptor (TIR) domain-containing protein with leucine-rich repeats similar to Gallus gallus toll-like receptor 2; the TIR domain is responsible for signal transduction in all toll-like receptors (TLR); toll/interleukin-1 receptor (TIR) domain-containing protein with leucine-rich repeats such as Bos taurus toll-like receptor 4; the TIR domain is responsible for signal transduction in all toll-like receptors (TLR); toll/interleukin-1 receptor (TIR) domain-containing protein with leucine-rich repeats such as Rattus norvegicus toll-like receptor 4; the TIR domain is responsible for signal transduction in all toll-like receptors (TLR); toll/interleukin-1 receptor (TIR) domain-containing protein with leucine-rich repeats; the TIR domain is responsible for signal transduction in all toll-like receptors (TLR); toll/interleukin-1 receptor (TIR) domain-containing protein with leucine-rich repeats similar to Cyprinus carpio toll-like receptor 20; the TIR domain is responsible for signal transduction in all toll-like receptors (TLR); toll/interleukin-1 receptor (TIR) domain-containing protein with leucine-rich repeats such as Rattus norvegicus toll-like receptor 4; the TIR domain is responsible for signal transduction in all toll-like receptors (TLR); toll/interleukin-1 receptor (TIR) domain-containing protein with leucine-rich repeats similar to Gallus gallus toll-like receptor 15; the TIR domain is responsible for signal transduction in all toll-like receptors (TLR); toll/interleukin-1 receptor (TIR) domain-containing protein with leucine-rich repeats; the TIR domain is responsible for signal transduction in all toll-like receptors (TLR); toll/interleukin-1 receptor (TIR) domain-containing protein with leucine-rich repeats such as Mus musculus toll-like receptor 12; the TIR domain is responsible for signal transduction in all toll-like receptors (TLR); toll/interleukin-1 receptor (TIR) domain-containing protein with leucine-rich repeats such as Rattus norvegicus toll-like receptor 4; the TIR domain is responsible for signal transduction in all toll-like receptors (TLR); toll/interleukin-1 receptor (TIR) domain-containing protein with leucine-rich repeats such as Rattus norvegicus toll-like receptor 4; the TIR domain is responsible for signal transduction in all toll-like receptors (TLR); toll/interleukin-1 receptor (TIR) domain-containing protein with leucine-rich repeats; the TIR domain is responsible for signal transduction in all toll-like receptors (TLR); toll/interleukin-1 receptor (TIR) domain-containing protein with leucine-rich repeats similar to Ctenopharyngodon idella toll-like receptor 21; the TIR domain is responsible for signal transduction in all toll-like receptors (TLR); toll/interleukin-1 receptor (TIR) domain-containing protein with leucine-rich repeats similar to Cyprinus carpio toll-like receptor 20; the TIR domain is responsible for signal transduction in all toll-like receptors (TLR); toll/interleukin-1 receptor (TIR) domain-containing protein with leucine-rich repeats similar to toll-like receptor 4; the TIR domain is responsible for signal transduction in all toll-like receptors (TLR); toll/interleukin-1 receptor (TIR) domain-containing protein with leucine-rich repeats such as Rattus norvegicus toll-like receptor 4; the TIR domain is responsible for signal transduction in all toll-like receptors (TLR); toll/interleukin-1 receptor (TIR) domain-containing protein with leucine-rich repeats; the TIR domain is responsible for signal transduction in all toll-like receptors (TLR); toll/interleukin-1 r

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
478-785 5.87e-22

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 100.01  E-value: 5.87e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093   478 KNKEASFMSVNESCYKYGQTLDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLDLL 557
Cdd:COG4886    8 LTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093   558 HSTAFEELHKLEVLDISSNshyfqsegithmlNFTKNLKVLQKLMMNDNDISSSTSRTMESESLRTLEFRGNHLDVLWRE 637
Cdd:COG4886   88 GLTDLGDLTNLTELDLSGN-------------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEP 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093   638 gdnrylqlFKNLLKLEELDISKNSLSFLPSGVFDgmPPNLKNLSLAKNGLKSFSwKKLQCLKNLETLDLSHNQLTTVPER 717
Cdd:COG4886  155 --------LGNLTNLKSLDLSNNQLTDLPEELGN--LTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPEP 223

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 7706093   718 LSNCSrSLKNLILKNNQIRSLTKyfLQDAFQLRYLDLSSNKIqmiqkTSFPENV-LNNLKMLLLHHNRF 785
Cdd:COG4886  224 LANLT-NLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQL-----TDLPPLAnLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
109-434 1.23e-17

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.53  E-value: 1.23e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093   109 NNMCIKRLQIKPRSFSGLTYLKSLYLDGNQLLEIPQGLPPSLQLLSLEANNIFSIRKENLTELANIEILYLGQNCYYRNP 188
Cdd:COG4886    1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093   189 CYVSYSIEKDAFLNLTKLKVLSLKDNNVTAVPTvlpsTLTELYLYNNMIAKIqEDDFNNLNQLQILDLSGNcprcynapf 268
Cdd:COG4886   81 LLSLLLLGLTDLGDLTNLTELDLSGNEELSNLT----NLESLDLSGNQLTDL-PEELANLTNLKELDLSNN--------- 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093   269 pcapcknnsPLQIPVNAFDALTELKVLRLHSNSLQHVPPrWFKNINKLQELDLSQN---FLAKEIGDakflhfLPSLIQL 345
Cdd:COG4886  147 ---------QLTDLPEPLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNqitDLPEPLGN------LTNLEEL 210

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093   346 DLSFNfELQvyrasmNLSQAFSSLKSLKILRIRGyvfKELKSfnLSPLHNLQNLEVLDLGTNfiKIANLSMFKQFKRLKV 425
Cdd:COG4886  211 DLSGN-QLT------DLPEPLANLTNLETLDLSN---NQLTD--LPELGNLTNLEELDLSNN--QLTDLPPLANLTNLKT 276


                 ....*....
gi 7706093   426 IDLSVNKIS 434
Cdd:COG4886  277 LDLSNNQLT 285
TIR smart00255
Toll - interleukin 1 - resistance;
890-993 1.21e-12

Toll - interleukin 1 - resistance;


:

Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 66.19  E-value: 1.21e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093      890 CYDAFIVYdtkdpAVTEWVLAELVAKLEDpREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTDKYAKTENFKI 969
Cdd:smart00255    1 EYDVFISY-----SGKEDVRNEFLSHLLE-KLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLD 74

                            90       100
                    ....*....|....*....|....
gi 7706093      970 AFYLSHQRLMDEKVDVIILIFLEK 993
Cdd:smart00255   75 ELVAALENALEEGGLRVIPIFYEV 98
PCC super family cl28216
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 753-837 1.54e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


The actual alignment was detected with superfamily member TIGR00864:

Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 49.31  E-value: 1.54e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093     753 DLSSNKIQMIQKTSFpeNVLNNLKMLLLHHNRFLCTCDAVWFVWWVNHTEVTI--PYLAtdvTCVGPGAHKGQSVISLDL 830
Cdd:TIGR00864    1 DISNNKISTIEEGIC--ANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVrqPEAA---LCAGPGALAGQPLLGIPL 75


                   ....*..
gi 7706093     831 YTCELDL 837
Cdd:TIGR00864   76 LDSGCDE 82
LRR_8 super family cl38440
Leucine rich repeat;
75-139 1.44e-03

Leucine rich repeat;


The actual alignment was detected with superfamily member pfam13855:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.89  E-value: 1.44e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 7706093      75 NHIPDISPASFHRLDHLVEIDFRCNCVPIplgsknnmcikrlqIKPRSFSGLTYLKSLYLDGNQL 139
Cdd:pfam13855   11 NRLTSLDDGAFKGLSNLKVLDLSNNLLTT--------------LSPGAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
478-785 5.87e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 100.01  E-value: 5.87e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093   478 KNKEASFMSVNESCYKYGQTLDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLDLL 557
Cdd:COG4886    8 LTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093   558 HSTAFEELHKLEVLDISSNshyfqsegithmlNFTKNLKVLQKLMMNDNDISSSTSRTMESESLRTLEFRGNHLDVLWRE 637
Cdd:COG4886   88 GLTDLGDLTNLTELDLSGN-------------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEP 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093   638 gdnrylqlFKNLLKLEELDISKNSLSFLPSGVFDgmPPNLKNLSLAKNGLKSFSwKKLQCLKNLETLDLSHNQLTTVPER 717
Cdd:COG4886  155 --------LGNLTNLKSLDLSNNQLTDLPEELGN--LTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPEP 223

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 7706093   718 LSNCSrSLKNLILKNNQIRSLTKyfLQDAFQLRYLDLSSNKIqmiqkTSFPENV-LNNLKMLLLHHNRF 785
Cdd:COG4886  224 LANLT-NLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQL-----TDLPPLAnLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
109-434 1.23e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.53  E-value: 1.23e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093   109 NNMCIKRLQIKPRSFSGLTYLKSLYLDGNQLLEIPQGLPPSLQLLSLEANNIFSIRKENLTELANIEILYLGQNCYYRNP 188
Cdd:COG4886    1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093   189 CYVSYSIEKDAFLNLTKLKVLSLKDNNVTAVPTvlpsTLTELYLYNNMIAKIqEDDFNNLNQLQILDLSGNcprcynapf 268
Cdd:COG4886   81 LLSLLLLGLTDLGDLTNLTELDLSGNEELSNLT----NLESLDLSGNQLTDL-PEELANLTNLKELDLSNN--------- 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093   269 pcapcknnsPLQIPVNAFDALTELKVLRLHSNSLQHVPPrWFKNINKLQELDLSQN---FLAKEIGDakflhfLPSLIQL 345
Cdd:COG4886  147 ---------QLTDLPEPLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNqitDLPEPLGN------LTNLEEL 210

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093   346 DLSFNfELQvyrasmNLSQAFSSLKSLKILRIRGyvfKELKSfnLSPLHNLQNLEVLDLGTNfiKIANLSMFKQFKRLKV 425
Cdd:COG4886  211 DLSGN-QLT------DLPEPLANLTNLETLDLSN---NQLTD--LPELGNLTNLEELDLSNN--QLTDLPPLANLTNLKT 276


                 ....*....
gi 7706093   426 IDLSVNKIS 434
Cdd:COG4886  277 LDLSNNQLT 285
TIR smart00255
Toll - interleukin 1 - resistance;
890-993 1.21e-12

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 66.19  E-value: 1.21e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093      890 CYDAFIVYdtkdpAVTEWVLAELVAKLEDpREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTDKYAKTENFKI 969
Cdd:smart00255    1 EYDVFISY-----SGKEDVRNEFLSHLLE-KLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLD 74

                            90       100
                    ....*....|....*....|....
gi 7706093      970 AFYLSHQRLMDEKVDVIILIFLEK 993
Cdd:smart00255   75 ELVAALENALEEGGLRVIPIFYEV 98
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 191-711 4.83e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 70.26  E-value: 4.83e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093    191 VSYSIEKDAFLNLTKLKVLSLKDNNVT-AVPTVLPSTLTELYLYNNMIAKIQEDDFNNLNQLQILDLSGNCPRCynapfp 269
Cdd:PLN00113  105 LSGPIPDDIFTTSSSLRYLNLSNNNFTgSIPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVG------ 178

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093    270 capcknnsplQIPvNAFDALTELKVLRLHSNSLQHVPPRWFKNINKLQELDLSQNFLAKEIgdAKFLHFLPSLIQLDLSF 349
Cdd:PLN00113  179 ----------KIP-NSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEI--PYEIGGLTSLNHLDLVY 245

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093    350 NfelqvyrasmNLS-QAFSSLKSLKILRIRgYVFKELKSFNLSP-LHNLQNLEVLDLGTNFIKIANLSMFKQFKRLKVID 427
Cdd:PLN00113  246 N----------NLTgPIPSSLGNLKNLQYL-FLYQNKLSGPIPPsIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILH 314

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093    428 LSVNKISpsgDSSEVGFCSNARTsvesyepQVLeQLhyfrydkyarscrFKNKEASFMSVNESCYKYGQTLDLSKNS--- 504
Cdd:PLN00113  315 LFSNNFT---GKIPVALTSLPRL-------QVL-QL-------------WSNKFSGEIPKNLGKHNNLTVLDLSTNNltg 370

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093    505 ---------------IFFVKSSDFQ------HLSFLKCLNLSGNLISQTLNgSEFQPLAELRYLDFSNNRLDLLHSTAFE 563
Cdd:PLN00113  371 eipeglcssgnlfklILFSNSLEGEipkslgACRSLRRVRLQDNSFSGELP-SEFTKLPLVYFLDISNNNLQGRINSRKW 449

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093    564 ELHKLEVLDISSNshyfqsegithmlNFTKNL------KVLQKLMMNDNDISSSTSRTMESES-LRTLEFRGNHLD-VLW 635
Cdd:PLN00113  450 DMPSLQMLSLARN-------------KFFGGLpdsfgsKRLENLDLSRNQFSGAVPRKLGSLSeLMQLKLSENKLSgEIP 516

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 7706093    636 REgdnryLQLFKNLLkleELDISKNSLS-FLPSGvFDGMPPnLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQL 711
Cdd:PLN00113  517 DE-----LSSCKKLV---SLDLSHNQLSgQIPAS-FSEMPV-LSQLDLSQNQLSGEIPKNLGNVESLVQVNISHNHL 583
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 157-576 4.64e-11

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 67.18  E-value: 4.64e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093    157 ANNIFSIRKEN-LTELANIEILYLGQNCYY-RNPCYVSysiekdaflNLTKLKVLSLKDNNVTA-VPTVLPS--TLTELY 231
Cdd:PLN00113  148 SNNMLSGEIPNdIGSFSSLKVLDLGGNVLVgKIPNSLT---------NLTSLEFLTLASNQLVGqIPRELGQmkSLKWIY 218

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093    232 L-YNNMIAKIQEDdFNNLNQLQILDLsgncprcynapfpcapCKNNSPLQIPVnAFDALTELKVLRLHSNSLQ-HVPPRW 309
Cdd:PLN00113  219 LgYNNLSGEIPYE-IGGLTSLNHLDL----------------VYNNLTGPIPS-SLGNLKNLQYLFLYQNKLSgPIPPSI 280

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093    310 FkNINKLQELDLSQNFLAKEIgdakflhflPSL-IQLDlsfNFELqVYRASMNLS----QAFSSLKSLKIL-----RIRG 379
Cdd:PLN00113  281 F-SLQKLISLDLSDNSLSGEI---------PELvIQLQ---NLEI-LHLFSNNFTgkipVALTSLPRLQVLqlwsnKFSG 346

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093    380 YVFKELKSFNlsplhnlqNLEVLDLGTN------------------FIKIAN---------LSMFKQFKRLKVIDLSVNK 432
Cdd:PLN00113  347 EIPKNLGKHN--------NLTVLDLSTNnltgeipeglcssgnlfkLILFSNslegeipksLGACRSLRRVRLQDNSFSG 418

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093    433 ISPSG----------DSSEVGFcsNARTSVESYEPQVLEQLhyfrydKYARSCRFKNKEASFMSVNEscykygQTLDLSK 502
Cdd:PLN00113  419 ELPSEftklplvyflDISNNNL--QGRINSRKWDMPSLQML------SLARNKFFGGLPDSFGSKRL------ENLDLSR 484

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 7706093    503 NSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNgSEFQPLAELRYLDFSNNRLDLLHSTAFEELHKLEVLDISSN 576
Cdd:PLN00113  485 NQFSGAVPRKLGSLSELMQLKLSENKLSGEIP-DELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQN 557
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 891-1016 1.38e-08

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 55.06  E-value: 1.38e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093     891 YDAFIVYDTKDpaVTEWVLAELVAKLedpREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTDKYAKT----EN 966
Cdd:pfam01582    1 YDVFLSFRGSD--TREWFVSHLLKEL---KQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSgwclDE 75

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 7706093     967 FKIAfylshQRLMDEKVDVIILIFLEK-----PFQKSKFLQLRKRLCG----SSVLEWP 1016
Cdd:pfam01582   76 LVKI-----LECALDLGQKVIPIFYEVdpsdvRKQTGSFGKAFKKHKKvlteEKVLKWR 129
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 535-759 2.15e-08

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 56.98  E-value: 2.15e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093   535 GSEFQPLAELRYLDFSNNRLDLLHSTAFEELHK---LEVLDISSNShyfqsEGITHmlnftknLKVLQKlmmndndisss 611
Cdd:cd00116   74 LQGLTKGCGLQELDLSDNALGPDGCGVLESLLRsssLQELKLNNNG-----LGDRG-------LRLLAK----------- 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093   612 tSRTMESESLRTLEFRGNHLDVlwrEGDNRYLQLFKNLLKLEELDISKNSLsfLPSGV---FDGMP--PNLKNLSLAKNG 686
Cdd:cd00116  131 -GLKDLPPALEKLVLGRNRLEG---ASCEALAKALRANRDLKELNLANNGI--GDAGIralAEGLKanCNLEVLDLNNNG 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093   687 LKSFSWKKL----QCLKNLETLDLSHNQLTTVP-----ERLSNCSRSLKNLILKNNQI-----RSLTKYfLQDAFQLRYL 752
Cdd:cd00116  205 LTDEGASALaetlASLKSLEVLNLGDNNLTDAGaaalaSALLSPNISLLTLSLSCNDItddgaKDLAEV-LAEKESLLEL 283


                 ....*..
gi 7706093   753 DLSSNKI 759
Cdd:cd00116  284 DLRGNKF 290
LRR_8 pfam13855
Leucine rich repeat;
675-735 6.83e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.22  E-value: 6.83e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 7706093     675 PNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSNCSRSLKNLILKNNQI 735
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
290-350 1.68e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.06  E-value: 1.68e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 7706093     290 TELKVLRLHSNSLQHVPPRWFKNINKLQELDLSQNFLaKEIGDAKFLHfLPSLIQLDLSFN 350
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL-TTLSPGAFSG-LPSLRYLDLSGN 59
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 203-434 4.87e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 51.71  E-value: 4.87e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093   203 LTKLKVLSLKDNNVTAVPTVLPST-LTELYLYNNMIAKIqeDDFNNLNQLQILDLSGNCPRCynapfpcapcknnsplqi 281
Cdd:cd21340    1 LKRITHLYLNDKNITKIDNLSLCKnLKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIEK------------------ 60

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093   282 pVNAFDALTELKVLRLHSNSLQHVppRWFKNINKLQELDLS-QNflakeigdakflhflpslIQLDLSFNFElqvYRASM 360
Cdd:cd21340   61 -IENLENLVNLKKLYLGGNRISVV--EGLENLTNLEELHIEnQR------------------LPPGEKLTFD---PRSLA 116

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 7706093   361 NLSqafsslKSLKILRIRGyvfkeLKSFNLSPLHNLQNLEVLDLGTNFIK-IANLS-MFKQFKRLKVIDLSVNKIS 434
Cdd:cd21340  117 ALS------NSLRVLNISG-----NNIDSLEPLAPLRNLEQLDASNNQISdLEELLdLLSSWPSLRELDLTGNPVC 181
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 753-837 1.54e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 49.31  E-value: 1.54e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093     753 DLSSNKIQMIQKTSFpeNVLNNLKMLLLHHNRFLCTCDAVWFVWWVNHTEVTI--PYLAtdvTCVGPGAHKGQSVISLDL 830
Cdd:TIGR00864    1 DISNNKISTIEEGIC--ANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVrqPEAA---LCAGPGALAGQPLLGIPL 75


                   ....*..
gi 7706093     831 YTCELDL 837
Cdd:TIGR00864   76 LDSGCDE 82
LRR_8 pfam13855
Leucine rich repeat;
75-139 1.44e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.89  E-value: 1.44e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 7706093      75 NHIPDISPASFHRLDHLVEIDFRCNCVPIplgsknnmcikrlqIKPRSFSGLTYLKSLYLDGNQL 139
Cdd:pfam13855   11 NRLTSLDDGAFKGLSNLKVLDLSNNLLTT--------------LSPGAFSGLPSLRYLDLSGNRL 61
LRR smart00370
Leucine-rich repeats, outliers;
698-721 9.10e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 34.63  E-value: 9.10e-03
                            10        20
                    ....*....|....*....|....
gi 7706093      698 LKNLETLDLSHNQLTTVPERLSNC 721
Cdd:smart00370    1 LPNLRELDLSNNQLSSLPPGAFQG 24
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
478-785 5.87e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 100.01  E-value: 5.87e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093   478 KNKEASFMSVNESCYKYGQTLDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLDLL 557
Cdd:COG4886    8 LTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093   558 HSTAFEELHKLEVLDISSNshyfqsegithmlNFTKNLKVLQKLMMNDNDISSSTSRTMESESLRTLEFRGNHLDVLWRE 637
Cdd:COG4886   88 GLTDLGDLTNLTELDLSGN-------------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEP 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093   638 gdnrylqlFKNLLKLEELDISKNSLSFLPSGVFDgmPPNLKNLSLAKNGLKSFSwKKLQCLKNLETLDLSHNQLTTVPER 717
Cdd:COG4886  155 --------LGNLTNLKSLDLSNNQLTDLPEELGN--LTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPEP 223

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 7706093   718 LSNCSrSLKNLILKNNQIRSLTKyfLQDAFQLRYLDLSSNKIqmiqkTSFPENV-LNNLKMLLLHHNRF 785
Cdd:COG4886  224 LANLT-NLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQL-----TDLPPLAnLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
496-840 8.89e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 89.99  E-value: 8.89e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093   496 QTLDLSKNSiffvkssDFQHLSFLKCLNLSGNLISQTlnGSEFQPLAELRYLDFSNNRLDLLHStAFEELHKLEVLDISS 575
Cdd:COG4886   99 TELDLSGNE-------ELSNLTNLESLDLSGNQLTDL--PEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSN 168

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093   576 NshyfqseGITHMLNFTKNLKVLQKLMMNDNDISSSTSRTMESESLRTLEFRGNHLDVLWREgdnrylqlFKNLLKLEEL 655
Cdd:COG4886  169 N-------QLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEP--------LANLTNLETL 233

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093   656 DISKNSLSFLPSgvFDGMPpNLKNLSLAKNGLKSFSwkKLQCLKNLETLDLSHNQLTTVP-ERLSNCSRSLKNLILKNNQ 734
Cdd:COG4886  234 DLSNNQLTDLPE--LGNLT-NLEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQLTDLKlKELELLLGLNSLLLLLLLL 308

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093   735 IRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLLHHNRFLCTCDAVWFVWWVNHTEVTIPYLATDVTC 814
Cdd:COG4886  309 NLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLT 388

                        330       340
                 ....*....|....*....|....*.
gi 7706093   815 VGPGAHKGQSVISLDLYTCELDLTNL 840
Cdd:COG4886  389 LLLLLLTTTAGVLLLTLALLDAVNTE 414
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
109-434 1.23e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.53  E-value: 1.23e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093   109 NNMCIKRLQIKPRSFSGLTYLKSLYLDGNQLLEIPQGLPPSLQLLSLEANNIFSIRKENLTELANIEILYLGQNCYYRNP 188
Cdd:COG4886    1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093   189 CYVSYSIEKDAFLNLTKLKVLSLKDNNVTAVPTvlpsTLTELYLYNNMIAKIqEDDFNNLNQLQILDLSGNcprcynapf 268
Cdd:COG4886   81 LLSLLLLGLTDLGDLTNLTELDLSGNEELSNLT----NLESLDLSGNQLTDL-PEELANLTNLKELDLSNN--------- 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093   269 pcapcknnsPLQIPVNAFDALTELKVLRLHSNSLQHVPPrWFKNINKLQELDLSQN---FLAKEIGDakflhfLPSLIQL 345
Cdd:COG4886  147 ---------QLTDLPEPLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNqitDLPEPLGN------LTNLEEL 210

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093   346 DLSFNfELQvyrasmNLSQAFSSLKSLKILRIRGyvfKELKSfnLSPLHNLQNLEVLDLGTNfiKIANLSMFKQFKRLKV 425
Cdd:COG4886  211 DLSGN-QLT------DLPEPLANLTNLETLDLSN---NQLTD--LPELGNLTNLEELDLSNN--QLTDLPPLANLTNLKT 276


                 ....*....
gi 7706093   426 IDLSVNKIS 434
Cdd:COG4886  277 LDLSNNQLT 285
TIR smart00255
Toll - interleukin 1 - resistance;
890-993 1.21e-12

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 66.19  E-value: 1.21e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093      890 CYDAFIVYdtkdpAVTEWVLAELVAKLEDpREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTDKYAKTENFKI 969
Cdd:smart00255    1 EYDVFISY-----SGKEDVRNEFLSHLLE-KLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLD 74

                            90       100
                    ....*....|....*....|....
gi 7706093      970 AFYLSHQRLMDEKVDVIILIFLEK 993
Cdd:smart00255   75 ELVAALENALEEGGLRVIPIFYEV 98
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 191-711 4.83e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 70.26  E-value: 4.83e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093    191 VSYSIEKDAFLNLTKLKVLSLKDNNVT-AVPTVLPSTLTELYLYNNMIAKIQEDDFNNLNQLQILDLSGNCPRCynapfp 269
Cdd:PLN00113  105 LSGPIPDDIFTTSSSLRYLNLSNNNFTgSIPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVG------ 178

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093    270 capcknnsplQIPvNAFDALTELKVLRLHSNSLQHVPPRWFKNINKLQELDLSQNFLAKEIgdAKFLHFLPSLIQLDLSF 349
Cdd:PLN00113  179 ----------KIP-NSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEI--PYEIGGLTSLNHLDLVY 245

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093    350 NfelqvyrasmNLS-QAFSSLKSLKILRIRgYVFKELKSFNLSP-LHNLQNLEVLDLGTNFIKIANLSMFKQFKRLKVID 427
Cdd:PLN00113  246 N----------NLTgPIPSSLGNLKNLQYL-FLYQNKLSGPIPPsIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILH 314

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093    428 LSVNKISpsgDSSEVGFCSNARTsvesyepQVLeQLhyfrydkyarscrFKNKEASFMSVNESCYKYGQTLDLSKNS--- 504
Cdd:PLN00113  315 LFSNNFT---GKIPVALTSLPRL-------QVL-QL-------------WSNKFSGEIPKNLGKHNNLTVLDLSTNNltg 370

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093    505 ---------------IFFVKSSDFQ------HLSFLKCLNLSGNLISQTLNgSEFQPLAELRYLDFSNNRLDLLHSTAFE 563
Cdd:PLN00113  371 eipeglcssgnlfklILFSNSLEGEipkslgACRSLRRVRLQDNSFSGELP-SEFTKLPLVYFLDISNNNLQGRINSRKW 449

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093    564 ELHKLEVLDISSNshyfqsegithmlNFTKNL------KVLQKLMMNDNDISSSTSRTMESES-LRTLEFRGNHLD-VLW 635
Cdd:PLN00113  450 DMPSLQMLSLARN-------------KFFGGLpdsfgsKRLENLDLSRNQFSGAVPRKLGSLSeLMQLKLSENKLSgEIP 516

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 7706093    636 REgdnryLQLFKNLLkleELDISKNSLS-FLPSGvFDGMPPnLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQL 711
Cdd:PLN00113  517 DE-----LSSCKKLV---SLDLSHNQLSgQIPAS-FSEMPV-LSQLDLSQNQLSGEIPKNLGNVESLVQVNISHNHL 583
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 157-576 4.64e-11

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 67.18  E-value: 4.64e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093    157 ANNIFSIRKEN-LTELANIEILYLGQNCYY-RNPCYVSysiekdaflNLTKLKVLSLKDNNVTA-VPTVLPS--TLTELY 231
Cdd:PLN00113  148 SNNMLSGEIPNdIGSFSSLKVLDLGGNVLVgKIPNSLT---------NLTSLEFLTLASNQLVGqIPRELGQmkSLKWIY 218

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093    232 L-YNNMIAKIQEDdFNNLNQLQILDLsgncprcynapfpcapCKNNSPLQIPVnAFDALTELKVLRLHSNSLQ-HVPPRW 309
Cdd:PLN00113  219 LgYNNLSGEIPYE-IGGLTSLNHLDL----------------VYNNLTGPIPS-SLGNLKNLQYLFLYQNKLSgPIPPSI 280

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093    310 FkNINKLQELDLSQNFLAKEIgdakflhflPSL-IQLDlsfNFELqVYRASMNLS----QAFSSLKSLKIL-----RIRG 379
Cdd:PLN00113  281 F-SLQKLISLDLSDNSLSGEI---------PELvIQLQ---NLEI-LHLFSNNFTgkipVALTSLPRLQVLqlwsnKFSG 346

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093    380 YVFKELKSFNlsplhnlqNLEVLDLGTN------------------FIKIAN---------LSMFKQFKRLKVIDLSVNK 432
Cdd:PLN00113  347 EIPKNLGKHN--------NLTVLDLSTNnltgeipeglcssgnlfkLILFSNslegeipksLGACRSLRRVRLQDNSFSG 418

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093    433 ISPSG----------DSSEVGFcsNARTSVESYEPQVLEQLhyfrydKYARSCRFKNKEASFMSVNEscykygQTLDLSK 502
Cdd:PLN00113  419 ELPSEftklplvyflDISNNNL--QGRINSRKWDMPSLQML------SLARNKFFGGLPDSFGSKRL------ENLDLSR 484

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 7706093    503 NSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNgSEFQPLAELRYLDFSNNRLDLLHSTAFEELHKLEVLDISSN 576
Cdd:PLN00113  485 NQFSGAVPRKLGSLSELMQLKLSENKLSGEIP-DELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQN 557
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
107-328 3.85e-10

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 63.95  E-value: 3.85e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093    107 SKNNMCIKRLQIKPRSFSGLTYLKSLYLDGNQLLEIPQGLPPSLQLLSLEANNIFSIrKENLTElaNIEILYLGQNCYYR 186
Cdd:PRK15370  179 NKTELRLKILGLTTIPACIPEQITTLILDNNELKSLPENLQGNIKTLYANSNQLTSI-PATLPD--TIQEMELSINRITE 255

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093    187 NPCYVSYSIEK-DAFLN-LT--------KLKVLSLKDNNVTAVPTVLPSTLTELYLYNNMIAKIQEDDFNNlnqLQILDL 256
Cdd:PRK15370  256 LPERLPSALQSlDLFHNkISclpenlpeELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTALPETLPPG---LKTLEA 332

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 7706093    257 SGNCPRCYNAPFPCA----PCKNNSPLQIPVNAFDALTELKVLRlhsNSLQHVPprwfKNI-NKLQELDLSQNFLAK 328
Cdd:PRK15370  333 GENALTSLPASLPPElqvlDVSKNQITVLPETLPPTITTLDVSR---NALTNLP----ENLpAALQIMQASRNNLVR 402
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 891-1016 1.38e-08

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 55.06  E-value: 1.38e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093     891 YDAFIVYDTKDpaVTEWVLAELVAKLedpREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTDKYAKT----EN 966
Cdd:pfam01582    1 YDVFLSFRGSD--TREWFVSHLLKEL---KQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSgwclDE 75

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 7706093     967 FKIAfylshQRLMDEKVDVIILIFLEK-----PFQKSKFLQLRKRLCG----SSVLEWP 1016
Cdd:pfam01582   76 LVKI-----LECALDLGQKVIPIFYEVdpsdvRKQTGSFGKAFKKHKKvlteEKVLKWR 129
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 497-786 1.55e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 59.09  E-value: 1.55e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093    497 TLDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLDLLHSTAFeeLHKLEVLDISSN 576
Cdd:PLN00113   73 SIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSGPIPDDIFTTSSSLRYLNLSNNNFTGSIPRGS--IPNLETLDLSNN 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093    577 shyFQSEGITHMLNFTKNLKVLQ--------KLMMNDNDISSSTSRTMESESL-----------RTLE--FRG------- 628
Cdd:PLN00113  151 ---MLSGEIPNDIGSFSSLKVLDlggnvlvgKIPNSLTNLTSLEFLTLASNQLvgqiprelgqmKSLKwiYLGynnlsge 227

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093    629 -----------NHLDVLWRE------------GDNRYLQLFKNLL------------KLEELDISKNSLS---------- 663
Cdd:PLN00113  228 ipyeiggltslNHLDLVYNNltgpipsslgnlKNLQYLFLYQNKLsgpippsifslqKLISLDLSDNSLSgeipelviql 307

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093    664 ------FLPSGVFDG-MP------PNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLT-TVPERLSNcSRSLKNLI 729
Cdd:PLN00113  308 qnleilHLFSNNFTGkIPvaltslPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTgEIPEGLCS-SGNLFKLI 386

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093    730 LKNNQI-----------RSLTKYFLQD------------AFQLRY-LDLSSNKIQMIQKTSFPEnvLNNLKMLLLHHNRF 785
Cdd:PLN00113  387 LFSNSLegeipkslgacRSLRRVRLQDnsfsgelpseftKLPLVYfLDISNNNLQGRINSRKWD--MPSLQMLSLARNKF 464


                  .
gi 7706093    786 L 786
Cdd:PLN00113  465 F 465
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 535-759 2.15e-08

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 56.98  E-value: 2.15e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093   535 GSEFQPLAELRYLDFSNNRLDLLHSTAFEELHK---LEVLDISSNShyfqsEGITHmlnftknLKVLQKlmmndndisss 611
Cdd:cd00116   74 LQGLTKGCGLQELDLSDNALGPDGCGVLESLLRsssLQELKLNNNG-----LGDRG-------LRLLAK----------- 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093   612 tSRTMESESLRTLEFRGNHLDVlwrEGDNRYLQLFKNLLKLEELDISKNSLsfLPSGV---FDGMP--PNLKNLSLAKNG 686
Cdd:cd00116  131 -GLKDLPPALEKLVLGRNRLEG---ASCEALAKALRANRDLKELNLANNGI--GDAGIralAEGLKanCNLEVLDLNNNG 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093   687 LKSFSWKKL----QCLKNLETLDLSHNQLTTVP-----ERLSNCSRSLKNLILKNNQI-----RSLTKYfLQDAFQLRYL 752
Cdd:cd00116  205 LTDEGASALaetlASLKSLEVLNLGDNNLTDAGaaalaSALLSPNISLLTLSLSCNDItddgaKDLAEV-LAEKESLLEL 283


                 ....*..
gi 7706093   753 DLSSNKI 759
Cdd:cd00116  284 DLRGNKF 290
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
567-779 2.18e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 58.17  E-value: 2.18e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093    567 KLEVLDISSNSHYFQSEGIT------HMLNFTKNLKV-LQKLMMNDNDISS------STSRTME-------------SES 620
Cdd:PRK15370  184 RLKILGLTTIPACIPEQITTlildnnELKSLPENLQGnIKTLYANSNQLTSipatlpDTIQEMElsinritelperlPSA 263

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093    621 LRTLEFRGNHLDVLwreGDN-----RYLQLFKNLLK---------LEELDISKNSLSFLPSGvfdgMPPNLKNLSLAKNG 686
Cdd:PRK15370  264 LQSLDLFHNKISCL---PENlpeelRYLSVYDNSIRtlpahlpsgITHLNVQSNSLTALPET----LPPGLKTLEAGENA 336

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093    687 LKSF------SWKKLQCLKN------------LETLDLSHNQLTTVPErlsNCSRSLKNLILKNNQIRSLTK---YFLQD 745
Cdd:PRK15370  337 LTSLpaslppELQVLDVSKNqitvlpetlpptITTLDVSRNALTNLPE---NLPAALQIMQASRNNLVRLPEslpHFRGE 413

                         250       260       270
                  ....*....|....*....|....*....|....
gi 7706093    746 AFQlryldlsSNKIqMIQKTSFPENVLNNLKMLL 779
Cdd:PRK15370  414 GPQ-------PTRI-IVEYNPFSERTIQNMQRLM 439
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 579-783 4.54e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 54.79  E-value: 4.54e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093   579 YFQSEGITHM--LNFTKNLKVLqklMMNDNDISSstsrtMES-ESLRTLEfrgnHLdvlwregdnrYLQlfKNLL-KLEE 654
Cdd:cd21340    8 YLNDKNITKIdnLSLCKNLKVL---YLYDNKITK-----IENlEFLTNLT----HL----------YLQ--NNQIeKIEN 63

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093   655 LDisknSLsflpsgvfdgmpPNLKNLSLAKN------GLksfswkklQCLKNLETLDLSHNQL------TTVPERLSNCS 722
Cdd:cd21340   64 LE----NL------------VNLKKLYLGGNrisvveGL--------ENLTNLEELHIENQRLppgeklTFDPRSLAALS 119

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 7706093   723 RSLKNLILKNNQIRSLTkyFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLLHHN 783
Cdd:cd21340  120 NSLRVLNISGNNIDSLE--PLAPLRNLEQLDASNNQISDLEELLDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
675-735 6.83e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.22  E-value: 6.83e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 7706093     675 PNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSNCSRSLKNLILKNNQI 735
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
604-785 1.18e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 55.32  E-value: 1.18e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093   604 NDNDISSSTSRTMESESLRTLEFRGNHLDVLWREGDNRYLQLFKNLLKLEELDISKNSLSFLPSGVFDGMPPNLKNLSLA 683
Cdd:COG4886    1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093   684 KNGLKSFSWKKLQCLKNLETL-----------------DLSHNQLTTVPERLSNCSrSLKNLILKNNQIRSLTKyFLQDA 746
Cdd:COG4886   81 LLSLLLLGLTDLGDLTNLTELdlsgneelsnltnleslDLSGNQLTDLPEELANLT-NLKELDLSNNQLTDLPE-PLGNL 158

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 7706093   747 FQLRYLDLSSNKIqmiqkTSFPENV--LNNLKMLLLHHNRF 785
Cdd:COG4886  159 TNLKSLDLSNNQL-----TDLPEELgnLTNLKELDLSNNQI 194
LRR_8 pfam13855
Leucine rich repeat;
290-350 1.68e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.06  E-value: 1.68e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 7706093     290 TELKVLRLHSNSLQHVPPRWFKNINKLQELDLSQNFLaKEIGDAKFLHfLPSLIQLDLSFN 350
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL-TTLSPGAFSG-LPSLRYLDLSGN 59
LRR_8 pfam13855
Leucine rich repeat;
496-554 1.82e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.06  E-value: 1.82e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 7706093     496 QTLDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISqTLNGSEFQPLAELRYLDFSNNRL 554
Cdd:pfam13855    4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLT-TLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 547-741 2.69e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 52.48  E-value: 2.69e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093   547 LDFSNNRLDLLHstAFEELHKLEVLdissnshYFQSEGITHM--LNFTKNLKVLQklmMNDNDISSstsrtMES-ESLRT 623
Cdd:cd21340    7 LYLNDKNITKID--NLSLCKNLKVL-------YLYDNKITKIenLEFLTNLTHLY---LQNNQIEK-----IENlENLVN 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093   624 LE---FRGNHLDVLwrEGdnrylqlFKNLLKLEELDISKNSLsflPSGV---FD-----GMPPNLKNLSLAKNGLKSFSW 692
Cdd:cd21340   70 LKklyLGGNRISVV--EG-------LENLTNLEELHIENQRL---PPGEkltFDprslaALSNSLRVLNISGNNIDSLEP 137

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 7706093   693 kkLQCLKNLETLDLSHNQLTTVPE---RLSNCsRSLKNLILKNNQIRSLTKY 741
Cdd:cd21340  138 --LAPLRNLEQLDASNNQISDLEElldLLSSW-PSLRELDLTGNPVCKKPKY 186
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 312-785 3.31e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 54.47  E-value: 3.31e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093    312 NINKLQELDLSQNFLAKEIGDAKFLhfLPSLIQLDLSFNfelqvyRASMNLSQA-FSSLKSLKILrirgyvfkELKSFNL 390
Cdd:PLN00113   67 NSSRVVSIDLSGKNISGKISSAIFR--LPYIQTINLSNN------QLSGPIPDDiFTTSSSLRYL--------NLSNNNF 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093    391 S---PLHNLQNLEVLDLGTNFIKIANLSMFKQFKRLKVIDLSVN----KISPS-GDSSEVGFCSNARTSVESYEPQVLEQ 462
Cdd:PLN00113  131 TgsiPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNvlvgKIPNSlTNLTSLEFLTLASNQLVGQIPRELGQ 210

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093    463 LH-----YFRYDKYarSCRFKNKEASFMSVNEscykygqtLDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSE 537
Cdd:PLN00113  211 MKslkwiYLGYNNL--SGEIPYEIGGLTSLNH--------LDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSI 280

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093    538 FQpLAELRYLDFSNNRLDLLHSTAFEELHKLEVLDISSNshyfqsegithmlNFTKNLKV-------LQKLMMNDNDISS 610
Cdd:PLN00113  281 FS-LQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSN-------------NFTGKIPValtslprLQVLQLWSNKFSG 346

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093    611 STSRTM-ESESLRTLEFRGNHL-----DVLWREGDNRYLQLFKNLLK------------LEELDISKNSLSF-LPSGvFD 671
Cdd:PLN00113  347 EIPKNLgKHNNLTVLDLSTNNLtgeipEGLCSSGNLFKLILFSNSLEgeipkslgacrsLRRVRLQDNSFSGeLPSE-FT 425

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093    672 GMPpnLKN-LSLAKNGLK----SFSWKklqcLKNLETLDLSHNQLT-TVPErlSNCSRSLKNLILKNNQIRSLTKYFLQD 745
Cdd:PLN00113  426 KLP--LVYfLDISNNNLQgrinSRKWD----MPSLQMLSLARNKFFgGLPD--SFGSKRLENLDLSRNQFSGAVPRKLGS 497

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|..
gi 7706093    746 AFQLRYLDLSSNKI--QMIQKTSFPENVLNnlkmLLLHHNRF 785
Cdd:PLN00113  498 LSELMQLKLSENKLsgEIPDELSSCKKLVS----LDLSHNQL 535
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 203-434 4.87e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 51.71  E-value: 4.87e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093   203 LTKLKVLSLKDNNVTAVPTVLPST-LTELYLYNNMIAKIqeDDFNNLNQLQILDLSGNCPRCynapfpcapcknnsplqi 281
Cdd:cd21340    1 LKRITHLYLNDKNITKIDNLSLCKnLKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIEK------------------ 60

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093   282 pVNAFDALTELKVLRLHSNSLQHVppRWFKNINKLQELDLS-QNflakeigdakflhflpslIQLDLSFNFElqvYRASM 360
Cdd:cd21340   61 -IENLENLVNLKKLYLGGNRISVV--EGLENLTNLEELHIEnQR------------------LPPGEKLTFD---PRSLA 116

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 7706093   361 NLSqafsslKSLKILRIRGyvfkeLKSFNLSPLHNLQNLEVLDLGTNFIK-IANLS-MFKQFKRLKVIDLSVNKIS 434
Cdd:cd21340  117 ALS------NSLRVLNISG-----NNIDSLEPLAPLRNLEQLDASNNQISdLEELLdLLSSWPSLRELDLTGNPVC 181
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 120-434 1.03e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 52.93  E-value: 1.03e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093    120 PRSFSGLTYLKSLYLDGNQLL-EIPQ--GLPPSLQLLSLEANNIFSIRKENLTELANIEILYLGQNcyyrnpcYVSYSIE 196
Cdd:PLN00113  205 PRELGQMKSLKWIYLGYNNLSgEIPYeiGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQN-------KLSGPIP 277

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093    197 KDAFlNLTKLKVLSLKDNNVTA-VPTVLPS--TLTELYLY-NNMIAKIQE-----------------------DDFNNLN 249
Cdd:PLN00113  278 PSIF-SLQKLISLDLSDNSLSGeIPELVIQlqNLEILHLFsNNFTGKIPValtslprlqvlqlwsnkfsgeipKNLGKHN 356

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093    250 QLQILDLSGNCprcYNAPFPCAPC-----------KNNSPLQIPvNAFDALTELKVLRLHSNSLQHVPPRWFKNINKLQE 318
Cdd:PLN00113  357 NLTVLDLSTNN---LTGEIPEGLCssgnlfklilfSNSLEGEIP-KSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYF 432

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093    319 LDLSQNFLAKEIGDAKFLhfLPSLIQLDLSFNfelqvyRASMNLSQAFSSlkslkilrirgyvfkelksfnlsplhnlQN 398
Cdd:PLN00113  433 LDISNNNLQGRINSRKWD--MPSLQMLSLARN------KFFGGLPDSFGS----------------------------KR 476

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 7706093    399 LEVLDLGTNFIKIANLSMFKQFKRLKVIDLSVNKIS 434
Cdd:PLN00113  477 LENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLS 512
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 206-447 1.23e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 51.59  E-value: 1.23e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093   206 LKVLSLKDNNVT-----AVPTVL--PSTLTELYLYNNMIAKIQE------DDFNNLNQLQILDLSgNCPRCYNAPFPCAP 272
Cdd:cd00116   25 LQVLRLEGNTLGeeaakALASALrpQPSLKELCLSLNETGRIPRglqsllQGLTKGCGLQELDLS-DNALGPDGCGVLES 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093   273 CKNNSPLQI-PVNafDALTELKVLRLHSNSLQHVPPRwfkninkLQELDLSQNFLAKEIGD--AKFLHFLPSLIQLDLSF 349
Cdd:cd00116  104 LLRSSSLQElKLN--NNGLGDRGLRLLAKGLKDLPPA-------LEKLVLGRNRLEGASCEalAKALRANRDLKELNLAN 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093   350 NfELQVyRASMNLSQAFSSLKSLKILRIRGYVFKELKSFNLSP-LHNLQNLEVLDLGTNFIKIANLS-----MFKQFKRL 423
Cdd:cd00116  175 N-GIGD-AGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAEtLASLKSLEVLNLGDNNLTDAGAAalasaLLSPNISL 252

                        250       260
                 ....*....|....*....|....
gi 7706093   424 KVIDLSVNKISPSGDSSEVGFCSN 447
Cdd:cd00116  253 LTLSLSCNDITDDGAKDLAEVLAE 276
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
522-718 2.03e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 52.01  E-value: 2.03e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093    522 LNLSGNLISQTlngSEFQPLAeLRYLDFSNNRLDLLHSTAFEELHKLEVLD--ISSNSHYFQSeGITHMLNFTKNLKVL- 598
Cdd:PRK15370  246 MELSINRITEL---PERLPSA-LQSLDLFHNKISCLPENLPEELRYLSVYDnsIRTLPAHLPS-GITHLNVQSNSLTALp 320

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093    599 QKLMMNdndissstsrtmesesLRTLEfrgnhldvlwrEGDNRYLQLFKNL-LKLEELDISKNSLSFLPsgvfDGMPPNL 677
Cdd:PRK15370  321 ETLPPG----------------LKTLE-----------AGENALTSLPASLpPELQVLDVSKNQITVLP----ETLPPTI 369

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 7706093    678 KNLSLAKNGLKSFSWKKLQCLKNLETldlSHNQLTTVPERL 718
Cdd:PRK15370  370 TTLDVSRNALTNLPENLPAALQIMQA---SRNNLVRLPESL 407
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
75-259 3.23e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 50.70  E-value: 3.23e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093    75 NHIPDIsPASFHRLDHLVEIDFRCN---CVPIPLGSKNNmcIKRL-----QIK--PRSFSGLTYLKSLYLDGNQLLEIPq 144
Cdd:COG4886  146 NQLTDL-PEPLGNLTNLKSLDLSNNqltDLPEELGNLTN--LKELdlsnnQITdlPEPLGNLTNLEELDLSGNQLTDLP- 221

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093   145 glppslqllsleannifsirkENLTELANIEILYLGQNcyyrnpcyvsySIEK-DAFLNLTKLKVLSLKDNNVTAVPTVL 223
Cdd:COG4886  222 ---------------------EPLANLTNLETLDLSNN-----------QLTDlPELGNLTNLEELDLSNNQLTDLPPLA 269

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 7706093   224 PST-LTELYLYNNMIAKIQEDDFNNLNQLQILDLSGN 259
Cdd:COG4886  270 NLTnLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLL 306
LRR_8 pfam13855
Leucine rich repeat;
519-576 3.31e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.21  E-value: 3.31e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 7706093     519 LKCLNLSGNLIsQTLNGSEFQPLAELRYLDFSNNRLDLLHSTAFEELHKLEVLDISSN 576
Cdd:pfam13855    3 LRSLDLSNNRL-TSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
LRR_8 pfam13855
Leucine rich repeat;
275-324 4.67e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.82  E-value: 4.67e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 7706093     275 NNSPLQIPVNAFDALTELKVLRLHSNSLQHVPPRWFKNINKLQELDLSQN 324
Cdd:pfam13855   10 NNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 894-992 7.56e-06

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 46.15  E-value: 7.56e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093     894 FIVYDTKDPAVTEWVLAELvakledpREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTDKYAKTENFKIAFYL 973
Cdd:pfam13676    2 FISYAGEDRAWAEWLADAL-------EAAGYRVWLDRWDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLESPWCRAEWEA 74

                           90
                   ....*....|....*....
gi 7706093     974 SHQRLMDEKvdVIILIFLE 992
Cdd:pfam13676   75 ALADPEGRK--RLIPVRLE 91
LRR_8 pfam13855
Leucine rich repeat;
723-785 1.52e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.28  E-value: 1.52e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 7706093     723 RSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPEnvLNNLKMLLLHHNRF 785
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSG--LPSLRYLDLSGNRL 61
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 753-837 1.54e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 49.31  E-value: 1.54e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093     753 DLSSNKIQMIQKTSFpeNVLNNLKMLLLHHNRFLCTCDAVWFVWWVNHTEVTI--PYLAtdvTCVGPGAHKGQSVISLDL 830
Cdd:TIGR00864    1 DISNNKISTIEEGIC--ANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVrqPEAA---LCAGPGALAGQPLLGIPL 75


                   ....*..
gi 7706093     831 YTCELDL 837
Cdd:TIGR00864   76 LDSGCDE 82
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
639-787 1.81e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 48.92  E-value: 1.81e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093    639 DNRYLQLFKNL-LKLEELDISKNSLSFLPSGvfdgMPPNLKNLSLAKNGLKSFSwKKLQclKNLETLDLSHNQLTTVPER 717
Cdd:PRK15370  208 NNELKSLPENLqGNIKTLYANSNQLTSIPAT----LPDTIQEMELSINRITELP-ERLP--SALQSLDLFHNKISCLPEN 280

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093    718 LSNcsrSLKNLILKNNQIRSLTKYFLQDafqLRYLDLSSNKIqmiqkTSFPENVLNNLKMLLLHHNRFLC 787
Cdd:PRK15370  281 LPE---ELRYLSVYDNSIRTLPAHLPSG---ITHLNVQSNSL-----TALPETLPPGLKTLEAGENALTS 339
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 498-665 5.41e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.55  E-value: 5.41e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093   498 LDLSKNSIffVKSSDFQHLSFLKCLNLSGNLISqTLNGseFQPLAELRYLDFSNNRLDLLHSTAFEE------LHKLEVL 571
Cdd:cd21340   51 LYLQNNQI--EKIENLENLVNLKKLYLGGNRIS-VVEG--LENLTNLEELHIENQRLPPGEKLTFDPrslaalSNSLRVL 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093   572 DISSNshyfqseGITHMLNFtKNLKVLQKLMMNDNDISS--STSRTMES-ESLRTLEFRGNHL--DVLWREgdnrylQLF 646
Cdd:cd21340  126 NISGN-------NIDSLEPL-APLRNLEQLDASNNQISDleELLDLLSSwPSLRELDLTGNPVckKPKYRD------KII 191

                        170       180
                 ....*....|....*....|..
gi 7706093   647 KNLLKLEELD---ISKNSLSFL 665
Cdd:cd21340  192 LASKSLEVLDgkeITDTERQFL 213
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 366-576 5.93e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.55  E-value: 5.93e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093   366 FSSLKSLKILrirgYVFK-ELKSfnLSPLHNLQNLEVLDLGTNFI-KIANLSMFKqfkRLKVIDLSVNKISpsgdssevg 443
Cdd:cd21340   20 LSLCKNLKVL----YLYDnKITK--IENLEFLTNLTHLYLQNNQIeKIENLENLV---NLKKLYLGGNRIS--------- 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093   444 fcsnartSVESYE-PQVLEQLHyfrydkyarscrfknkeasfmsVNESCYKYGQTLDLSKNSIFFVKSSdfqhlsfLKCL 522
Cdd:cd21340   82 -------VVEGLEnLTNLEELH----------------------IENQRLPPGEKLTFDPRSLAALSNS-------LRVL 125

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 7706093   523 NLSGNLISqtlNGSEFQPLAELRYLDFSNNRLDLLH--STAFEELHKLEVLDISSN 576
Cdd:cd21340  126 NISGNNID---SLEPLAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTGN 178
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 123-259 1.26e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 44.39  E-value: 1.26e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093   123 FSGLTYLKSLYLDGNQLLEIpqglppslqllsleannifsirkENLTELANIEILYLGQNC------------------- 183
Cdd:cd21340   42 LEFLTNLTHLYLQNNQIEKI-----------------------ENLENLVNLKKLYLGGNRisvveglenltnleelhie 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093   184 YYRNPCYVSYSIEKDAFLNLTK-LKVLSLKDNNVTAV-PTVLPSTLTELYLYNNMIAKIQE--DDFNNLNQLQILDLSGN 259
Cdd:cd21340   99 NQRLPPGEKLTFDPRSLAALSNsLRVLNISGNNIDSLePLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
620-711 1.27e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.97  E-value: 1.27e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093     620 SLRTLEFRGNHLDVLWREgdnrylqLFKNLLKLEELDISKNSLSFLPSGVFDGMPpnlknlslaknglksfswkklqclk 699
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDG-------AFKGLSNLKVLDLSNNLLTTLSPGAFSGLP------------------------- 49

                           90
                   ....*....|..
gi 7706093     700 NLETLDLSHNQL 711
Cdd:pfam13855   50 SLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 553-759 2.37e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 44.78  E-value: 2.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093   553 RLDLLHSTAFEELHKLEVLDISSNshYFQSEGIT------------HMLNFTKN----------LKVLQK------LMMN 604
Cdd:COG5238  167 LLAAISMAKALQNNSVETVYLGCN--QIGDEGIEelaealtqnttvTTLWLKRNpigdegaeilAEALKGnkslttLDLS 244

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093   605 DNDIS----SSTSRTMESE-SLRTLEFRGNHLDVlwrEGDNRYLQLFKNLLKLEELDISKNSLSFlpSGVFdGMPPNLKN 679
Cdd:COG5238  245 NNQIGdegvIALAEALKNNtTVETLYLSGNQIGA---EGAIALAKALQGNTTLTSLDLSVNRIGD--EGAI-ALAEGLQG 318

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093   680 ------LSLAKNGLKSFSW----KKLQCLKNLETLDLSHNQLT-----TVPERLSNCSrSLKNLILKNNQIRSLTKYFLQ 744
Cdd:COG5238  319 nktlhtLNLAYNGIGAQGAialaKALQENTTLHSLDLSDNQIGdegaiALAKYLEGNT-TLRELNLGKNNIGKQGAEALI 397

                        250
                 ....*....|....*...
gi 7706093   745 DAFQ---LRYLDLSSNKI 759
Cdd:COG5238  398 DALQtnrLHTLILDGNLI 415
LRR_12 pfam18837
Leucine-rich repeat; This Pfam entry includes some LRRs that fail to be detected with the ...
 399-428 3.43e-04

Leucine-rich repeat; This Pfam entry includes some LRRs that fail to be detected with the pfam00560 model. This entry represents one repeat unit.


Pssm-ID: 408607  Cd Length: 30  Bit Score: 38.87  E-value: 3.43e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 7706093     399 LEVLDLGTNFIKIANLSMFKQFKRLKVIDL 428
Cdd:pfam18837    1 LQTLHLQMNFINQAQLSIFGAFPGLRFVDL 30
LRR_8 pfam13855
Leucine rich repeat;
204-259 4.77e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.04  E-value: 4.77e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 7706093     204 TKLKVLSLKDNNVTAVPTVL---PSTLTELYLYNNMIAKIQEDDFNNLNQLQILDLSGN 259
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAfkgLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
LRR_8 pfam13855
Leucine rich repeat;
75-139 1.44e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.89  E-value: 1.44e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 7706093      75 NHIPDISPASFHRLDHLVEIDFRCNCVPIplgsknnmcikrlqIKPRSFSGLTYLKSLYLDGNQL 139
Cdd:pfam13855   11 NRLTSLDDGAFKGLSNLKVLDLSNNLLTT--------------LSPGAFSGLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 675-713 2.14e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.84  E-value: 2.14e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 7706093     675 PNLKNLSLAKNGLKSFSWkkLQCLKNLETLDLSHNQLTT 713
Cdd:pfam12799    1 PNLEVLDLSNNQITDIPP--LAKLPNLETLDLSGNNKIT 37
LRR_8 pfam13855
Leucine rich repeat;
543-608 8.46e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.58  E-value: 8.46e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 7706093     543 ELRYLDFSNNRLDLLHSTAFEELHKLEVLDISSNShyfqsegITHMLNFT-KNLKVLQKLMMNDNDI 608
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNL-------LTTLSPGAfSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 698-784 8.66e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.00  E-value: 8.66e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706093   698 LKNLETLDLSHNQLTTVPErLSNCsRSLKNLILKNNQIRSLTKyfLQDAFQLRYLDLSSNKIQMIQktsfPENVLNNLKM 777
Cdd:cd21340    1 LKRITHLYLNDKNITKIDN-LSLC-KNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIE----NLENLVNLKK 72


                 ....*..
gi 7706093   778 LLLHHNR 784
Cdd:cd21340   73 LYLGGNR 79
LRR smart00370
Leucine-rich repeats, outliers;
698-721 9.10e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 34.63  E-value: 9.10e-03
                            10        20
                    ....*....|....*....|....
gi 7706093      698 LKNLETLDLSHNQLTTVPERLSNC 721
Cdd:smart00370    1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
698-721 9.10e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 34.63  E-value: 9.10e-03
                            10        20
                    ....*....|....*....|....
gi 7706093      698 LKNLETLDLSHNQLTTVPERLSNC 721
Cdd:smart00369    1 LPNLRELDLSNNQLSSLPPGAFQG 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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