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Conserved domains on  [gi|7706174|ref|NP_057714|]
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maspardin isoform a [Homo sapiens]

Protein Classification

alpha/beta fold hydrolase( domain architecture ID 11426811)

alpha/beta hydrolase family protein catalyzes the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

PubMed:  1409539|12369917

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
45-266 1.80e-12

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


:

Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 65.41  E-value: 1.80e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706174   45 PLIFLPPVSGTADVFFRQILALTGwGYRVIALQYPVY---------WDHLEFCDGFRKLLDHLQLDKVHLFGASLGGFLA 115
Cdd:COG0596  25 PVVLLHGLPGSSYEWRPLIPALAA-GYRVIAPDLRGHgrsdkpaggYTLDDLADDLAALLDALGLERVVLVGHSMGGMVA 103
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706174  116 QKFAEytHKSPRVHSLILCNSFSDtsifnqtwtansfWLMPAFmlkkivlgnfssgpvdPMMADAIDFMVDRLESLGQSE 195
Cdd:COG0596 104 LELAA--RHPERVAGLVLVDEVLA-------------ALAEPL----------------RRPGLAPEALAALLRALARTD 152
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 7706174  196 LASRLtlncqnsyvepHKIRdIPVTIMdVFDQSALST-EAKEEMYKLYPNARRAHLKTGGNFPYLCRSAEVN 266
Cdd:COG0596 153 LRERL-----------ARIT-VPTLVI-WGEKDPIVPpALARRLAELLPNAELVVLPGAGHFPPLEQPEAFA 211
 
Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
45-266 1.80e-12

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 65.41  E-value: 1.80e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706174   45 PLIFLPPVSGTADVFFRQILALTGwGYRVIALQYPVY---------WDHLEFCDGFRKLLDHLQLDKVHLFGASLGGFLA 115
Cdd:COG0596  25 PVVLLHGLPGSSYEWRPLIPALAA-GYRVIAPDLRGHgrsdkpaggYTLDDLADDLAALLDALGLERVVLVGHSMGGMVA 103
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706174  116 QKFAEytHKSPRVHSLILCNSFSDtsifnqtwtansfWLMPAFmlkkivlgnfssgpvdPMMADAIDFMVDRLESLGQSE 195
Cdd:COG0596 104 LELAA--RHPERVAGLVLVDEVLA-------------ALAEPL----------------RRPGLAPEALAALLRALARTD 152
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 7706174  196 LASRLtlncqnsyvepHKIRdIPVTIMdVFDQSALST-EAKEEMYKLYPNARRAHLKTGGNFPYLCRSAEVN 266
Cdd:COG0596 153 LRERL-----------ARIT-VPTLVI-WGEKDPIVPpALARRLAELLPNAELVVLPGAGHFPPLEQPEAFA 211
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
45-147 3.13e-09

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 56.36  E-value: 3.13e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706174     45 PLIFLPPVSGTADVFFRQILALTGWGYRVIALQYP--------------VYWDHLEFcdgFRKLLDHLQLDKVHLFGASL 110
Cdd:pfam00561   2 PVLLLHGLPGSSDLWRKLAPALARDGFRVIALDLRgfgkssrpkaqddyRTDDLAED---LEYILEALGLEKVNLVGHSM 78
                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 7706174    111 GGFLAqkfAEYTHKSP-RVHSLILCNSFSDTSIFNQTW 147
Cdd:pfam00561  79 GGLIA---LAYAAKYPdRVKALVLLGALDPPHELDEAD 113
 
Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
45-266 1.80e-12

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 65.41  E-value: 1.80e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706174   45 PLIFLPPVSGTADVFFRQILALTGwGYRVIALQYPVY---------WDHLEFCDGFRKLLDHLQLDKVHLFGASLGGFLA 115
Cdd:COG0596  25 PVVLLHGLPGSSYEWRPLIPALAA-GYRVIAPDLRGHgrsdkpaggYTLDDLADDLAALLDALGLERVVLVGHSMGGMVA 103
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706174  116 QKFAEytHKSPRVHSLILCNSFSDtsifnqtwtansfWLMPAFmlkkivlgnfssgpvdPMMADAIDFMVDRLESLGQSE 195
Cdd:COG0596 104 LELAA--RHPERVAGLVLVDEVLA-------------ALAEPL----------------RRPGLAPEALAALLRALARTD 152
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 7706174  196 LASRLtlncqnsyvepHKIRdIPVTIMdVFDQSALST-EAKEEMYKLYPNARRAHLKTGGNFPYLCRSAEVN 266
Cdd:COG0596 153 LRERL-----------ARIT-VPTLVI-WGEKDPIVPpALARRLAELLPNAELVVLPGAGHFPPLEQPEAFA 211
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
45-147 3.13e-09

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 56.36  E-value: 3.13e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706174     45 PLIFLPPVSGTADVFFRQILALTGWGYRVIALQYP--------------VYWDHLEFcdgFRKLLDHLQLDKVHLFGASL 110
Cdd:pfam00561   2 PVLLLHGLPGSSDLWRKLAPALARDGFRVIALDLRgfgkssrpkaqddyRTDDLAED---LEYILEALGLEKVNLVGHSM 78
                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 7706174    111 GGFLAqkfAEYTHKSP-RVHSLILCNSFSDTSIFNQTW 147
Cdd:pfam00561  79 GGLIA---LAYAAKYPdRVKALVLLGALDPPHELDEAD 113
EstA COG1075
Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and ...
35-132 8.32e-08

Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and metabolism];


Pssm-ID: 440693 [Multi-domain]  Cd Length: 106  Bit Score: 49.44  E-value: 8.32e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706174   35 YDAGPRsircPLIFLPPVSGTADVFFRQILALTGWGYRVIALQYPVY----WDHLEFCDGF-RKLLDHLQLDKVHLFGAS 109
Cdd:COG1075   1 YAATRY----PVVLVHGLGGSAASWAPLAPRLRAAGYPVYALNYPSTngsiEDSAEQLAAFvDAVLAATGAEKVDLVGHS 76
                        90       100
                ....*....|....*....|...
gi 7706174  110 LGGFLAQKFAEYTHKSPRVHSLI 132
Cdd:COG1075  77 MGGLVARYYLKRLGGAAKVARVV 99
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
45-137 7.04e-05

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 43.07  E-value: 7.04e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706174   45 PLIFLPPVSGTADVFFRQILALTGWGYRVIALQYP---------VYWDHLE-FCDGFRKLLDHLQLD---KVHLFGASLG 111
Cdd:COG2267  30 TVVLVHGLGEHSGRYAELAEALAAAGYAVLAFDLRghgrsdgprGHVDSFDdYVDDLRAALDALRARpglPVVLLGHSMG 109
                        90       100
                ....*....|....*....|....*.
gi 7706174  112 GFLAQKFAEytHKSPRVHSLILCNSF 137
Cdd:COG2267 110 GLIALLYAA--RYPDRVAGLVLLAPA 133
Abhydrolase_6 pfam12697
Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse ...
46-266 1.63e-04

Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse specificity.


Pssm-ID: 463673 [Multi-domain]  Cd Length: 211  Bit Score: 42.08  E-value: 1.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706174     46 LIFLPpvsGtADVFFRQILALTGWGYRVIALQYPVY------WDHLEFCDGFRKLLDHL-QLDKVHLFGASLGGFLAQKF 118
Cdd:pfam12697   1 VVLVH---G-AGLSAAPLAALLAAGVAVLAPDLPGHgsssppPLDLADLADLAALLDELgAARPVVLVGHSLGGAVALAA 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706174    119 AEYthksPRVHSLILCnsfsdTSIFNQTWTANSFWLMPAFMLKKIVLGNFSSGPVDPMMADAIDFMVDRLESlgqseLAS 198
Cdd:pfam12697  77 AAA----ALVVGVLVA-----PLAAPPGLLAALLALLARLGAALAAPAWLAAESLARGFLDDLPADAEWAAA-----LAR 142
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 7706174    199 RLTLNCQNSYVEPHKIRDIPVTIMDVFDQSALSTEAKEEMYKLYPNARRAHLKTGGNFPyLCRSAEVN 266
Cdd:pfam12697 143 LAALLAALALLPLAAWRDLPVPVLVLAEEDRLVPELAQRLLAALAGARLVVLPGAGHLP-LDDPEEVA 209
Thioesterase pfam00975
Thioesterase domain; Peptide synthetases are involved in the non-ribosomal synthesis of ...
45-142 6.94e-04

Thioesterase domain; Peptide synthetases are involved in the non-ribosomal synthesis of peptide antibiotics. Next to the operons encoding these enzymes, in almost all cases, are genes that encode proteins that have similarity to the type II fatty acid thioesterases of vertebrates. There are also modules within the peptide synthetases that also share this similarity. With respect to antibiotic production, thioesterases are required for the addition of the last amino acid to the peptide antibiotic, thereby forming a cyclic antibiotic. Thioesterases (non-integrated) have molecular masses of 25-29 kDa.


Pssm-ID: 395776 [Multi-domain]  Cd Length: 223  Bit Score: 40.06  E-value: 6.94e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706174     45 PLIFLPPVSGTADVFFRQILALTGWgYRVIALQYPVYWDHLEFCDGFRKLLD--------HLQLDKVHLFGASLGGFLAQ 116
Cdd:pfam00975   2 PLFCFPPAGGSASSFRSLARRLPPP-AEVLAVQYPGRGRGEPPLNSIEALADeyaealrqIQPEGPYALFGHSMGGMLAF 80
                          90       100
                  ....*....|....*....|....*..
gi 7706174    117 KFA-EYTHKSPRVHSLILcnsfSDTSI 142
Cdd:pfam00975  81 EVArRLERQGEAVRSLFL----SDASA 103
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
45-159 8.18e-03

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 36.92  E-value: 8.18e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706174   45 PLIFLP---PvSGTADVFFRQILALTGWGYRVIALQYPVY------WDHLEF---CDGFRKLLDHLQLD--KVHLFGASL 110
Cdd:COG1506  24 PVVVYVhggP-GSRDDSFLPLAQALASRGYAVLAPDYRGYgesagdWGGDEVddvLAAIDYLAARPYVDpdRIGIYGHSY 102
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 7706174  111 GGFLAQKFAeyTHKSPRVHSLILCNSFSDtsifNQTWTANSFWLMPAFM 159
Cdd:COG1506 103 GGYMALLAA--ARHPDRFKAAVALAGVSD----LRSYYGTTREYTERLM 145
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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