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Conserved domains on  [gi|254675168|ref|NP_058593|]
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mitochondrial import inner membrane translocase subunit Tim23 [Mus musculus]

Protein Classification

mitochondrial import inner membrane translocase subunit TIM23( domain architecture ID 10017560)

mitochondrial import inner membrane translocase subunit TIM23 is an essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane

Gene Ontology:  GO:0008320|GO:0030150|GO:0005744
PubMed:  27590886|20116361|10603473

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
3a0801s02tim23 TIGR00983
mitochondrial import inner membrane translocase subunit tim23; [Transport and binding proteins, ...
 46-191 1.59e-70

mitochondrial import inner membrane translocase subunit tim23; [Transport and binding proteins, Amino acids, peptides and amines]


:

Pssm-ID: 130056  Cd Length: 149  Bit Score: 211.62  E-value: 1.59e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675168   46 LNVDPRYLVQDTDEFILPTGANKTRGRFELAFFTIGGCCMTGAAFGAMNGLRLGLKETQSMAWSKPRNVQILNMVTRQGA 125
Cdd:TIGR00983   4 LDKDPEYLVQEEDELSLLTGANPSRGWFEDLCFGTGTCYLTGLAIGALNGLRLGLKETQSMPWTKLRLNQILNMVTRRGP 83

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 254675168  126 LWANTLGSLALLYSAFGVIIEKTRGAEDDLNTVAAGTMTGMLYKCTGGLRGIARGGLAGLTLTSLY 191
Cdd:TIGR00983  84 FWGNTLGILALVYNGINSIIEATRGKHDDFNSVAAGALTGALYKSTRGLRGMARSGALGATAAGVW 149
 
Name Accession Description Interval E-value
3a0801s02tim23 TIGR00983
mitochondrial import inner membrane translocase subunit tim23; [Transport and binding proteins, ...
 46-191 1.59e-70

mitochondrial import inner membrane translocase subunit tim23; [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 130056  Cd Length: 149  Bit Score: 211.62  E-value: 1.59e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675168   46 LNVDPRYLVQDTDEFILPTGANKTRGRFELAFFTIGGCCMTGAAFGAMNGLRLGLKETQSMAWSKPRNVQILNMVTRQGA 125
Cdd:TIGR00983   4 LDKDPEYLVQEEDELSLLTGANPSRGWFEDLCFGTGTCYLTGLAIGALNGLRLGLKETQSMPWTKLRLNQILNMVTRRGP 83

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 254675168  126 LWANTLGSLALLYSAFGVIIEKTRGAEDDLNTVAAGTMTGMLYKCTGGLRGIARGGLAGLTLTSLY 191
Cdd:TIGR00983  84 FWGNTLGILALVYNGINSIIEATRGKHDDFNSVAAGALTGALYKSTRGLRGMARSGALGATAAGVW 149
Tim17 pfam02466
Tim17/Tim22/Tim23/Pmp24 family; The pre-protein translocase of the mitochondrial outer ...
 77-184 3.35e-23

Tim17/Tim22/Tim23/Pmp24 family; The pre-protein translocase of the mitochondrial outer membrane (Tom) allows the import of pre-proteins from the cytoplasm. Tom forms a complex with a number of proteins, including Tim17. Tim17, Tim22, and Tim23, are the central components of the widely conserved multi-subunit protein translocases, TIM23 and TIM22, which mediate protein transport across and into the inner mitochondrial membrane, respectively. In addition, several Tim17 family proteins occupy the inner and outer membranes of plastids. This family also includes Pmp24 a peroxisomal protein. The involvement of this domain in the targeting of PMP24 remains to be proved. PMP24 was known as Pmp27. Family members are suggested to be exclusive to eukaryotes, where the distribution in the eukaryotic subgroups of the mitochondrial Tim17, Tim22 and Tim23 proteins, as well as the peroxisomal Tim17 family proteins, suggests that they all likely to be present in the last eukaryotic common ancestor (LECA).


Pssm-ID: 460567  Cd Length: 109  Bit Score: 89.15  E-value: 3.35e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675168   77 FFTIGGCCMTGAAFGAMNGLRLGLKETQSMAWSKPRNVQILNMVTRQGALWANTLGSLALLYSAFGVIIEKTRGAEDDLN 156
Cdd:pfam02466   2 LYKTGGAFLMGAVLGGVFGLVYGARNRPPPLTAKLRLRGALNAVGKRGPSLGNNFAVFGGLYSGIECGLEKYRGKEDPWN 81

                          90       100
                  ....*....|....*....|....*...
gi 254675168  157 TVAAGTMTGMLYKctGGLRGIARGGLAG 184
Cdd:pfam02466  82 SIAAGALTGALLR--GGPRAAAVGGAVG 107
TIM22 COG5596
Mitochondrial import inner membrane translocase, subunit TIM22 [Posttranslational modification, ...
 86-198 4.84e-06

Mitochondrial import inner membrane translocase, subunit TIM22 [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227883  Cd Length: 191  Bit Score: 45.23  E-value: 4.84e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675168  86 TGAAFGAMNGlrlGLKETQSMAWSKPRNVQILNMVTRQGALWANTLGSLALLYSAFGVIIEKTRGAEDDLNTVAAGTMTG 165
Cdd:COG5596   81 LGLNFGGVWG---GLFSTIDCTPFRLQLKEQLNNAGKRGFFTGKNLGVLGLIYAGINSIITALRAKHDIANAIAAGAFTG 157

                         90       100       110
                 ....*....|....*....|....*....|...
gi 254675168 166 MLYKCTGGLRGIARGGLAGLTLTSLYALYNNWE 198
Cdd:COG5596  158 AALASSAGPQAMPMGGAGFAAFSAGITLAMKSE 190
 
Name Accession Description Interval E-value
3a0801s02tim23 TIGR00983
mitochondrial import inner membrane translocase subunit tim23; [Transport and binding proteins, ...
 46-191 1.59e-70

mitochondrial import inner membrane translocase subunit tim23; [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 130056  Cd Length: 149  Bit Score: 211.62  E-value: 1.59e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675168   46 LNVDPRYLVQDTDEFILPTGANKTRGRFELAFFTIGGCCMTGAAFGAMNGLRLGLKETQSMAWSKPRNVQILNMVTRQGA 125
Cdd:TIGR00983   4 LDKDPEYLVQEEDELSLLTGANPSRGWFEDLCFGTGTCYLTGLAIGALNGLRLGLKETQSMPWTKLRLNQILNMVTRRGP 83

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 254675168  126 LWANTLGSLALLYSAFGVIIEKTRGAEDDLNTVAAGTMTGMLYKCTGGLRGIARGGLAGLTLTSLY 191
Cdd:TIGR00983  84 FWGNTLGILALVYNGINSIIEATRGKHDDFNSVAAGALTGALYKSTRGLRGMARSGALGATAAGVW 149
Tim17 pfam02466
Tim17/Tim22/Tim23/Pmp24 family; The pre-protein translocase of the mitochondrial outer ...
 77-184 3.35e-23

Tim17/Tim22/Tim23/Pmp24 family; The pre-protein translocase of the mitochondrial outer membrane (Tom) allows the import of pre-proteins from the cytoplasm. Tom forms a complex with a number of proteins, including Tim17. Tim17, Tim22, and Tim23, are the central components of the widely conserved multi-subunit protein translocases, TIM23 and TIM22, which mediate protein transport across and into the inner mitochondrial membrane, respectively. In addition, several Tim17 family proteins occupy the inner and outer membranes of plastids. This family also includes Pmp24 a peroxisomal protein. The involvement of this domain in the targeting of PMP24 remains to be proved. PMP24 was known as Pmp27. Family members are suggested to be exclusive to eukaryotes, where the distribution in the eukaryotic subgroups of the mitochondrial Tim17, Tim22 and Tim23 proteins, as well as the peroxisomal Tim17 family proteins, suggests that they all likely to be present in the last eukaryotic common ancestor (LECA).


Pssm-ID: 460567  Cd Length: 109  Bit Score: 89.15  E-value: 3.35e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675168   77 FFTIGGCCMTGAAFGAMNGLRLGLKETQSMAWSKPRNVQILNMVTRQGALWANTLGSLALLYSAFGVIIEKTRGAEDDLN 156
Cdd:pfam02466   2 LYKTGGAFLMGAVLGGVFGLVYGARNRPPPLTAKLRLRGALNAVGKRGPSLGNNFAVFGGLYSGIECGLEKYRGKEDPWN 81

                          90       100
                  ....*....|....*....|....*...
gi 254675168  157 TVAAGTMTGMLYKctGGLRGIARGGLAG 184
Cdd:pfam02466  82 SIAAGALTGALLR--GGPRAAAVGGAVG 107
TIM22 COG5596
Mitochondrial import inner membrane translocase, subunit TIM22 [Posttranslational modification, ...
 86-198 4.84e-06

Mitochondrial import inner membrane translocase, subunit TIM22 [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227883  Cd Length: 191  Bit Score: 45.23  E-value: 4.84e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675168  86 TGAAFGAMNGlrlGLKETQSMAWSKPRNVQILNMVTRQGALWANTLGSLALLYSAFGVIIEKTRGAEDDLNTVAAGTMTG 165
Cdd:COG5596   81 LGLNFGGVWG---GLFSTIDCTPFRLQLKEQLNNAGKRGFFTGKNLGVLGLIYAGINSIITALRAKHDIANAIAAGAFTG 157

                         90       100       110
                 ....*....|....*....|....*....|...
gi 254675168 166 MLYKCTGGLRGIARGGLAGLTLTSLYALYNNWE 198
Cdd:COG5596  158 AALASSAGPQAMPMGGAGFAAFSAGITLAMKSE 190
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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