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Conserved domains on  [gi|93102413|ref|NP_058601|]
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galactokinase [Mus musculus]

Protein Classification

galactokinase( domain architecture ID 11414964)

galactokinase catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
12-391 7.46e-171

Galactokinase [Carbohydrate transport and metabolism];


:

Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 481.96  E-value: 7.46e-171
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102413  12 LLAEARRAFMEEFGAEPELAVSAPGRVNLIGEHTDYNQGLVLPMALELVTVMVGSPRTDGLVSLlttsKDADEPQRLQFP 91
Cdd:COG0153   1 RLERLIEAFEEAFGEEPEGVFSAPGRVNLIGEHTDYNGGFVLPAAIDRGTYAAARPRDDRKVRV----YSADFDEEVEFD 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102413  92 LpsaqWSLEPG-IPQWANYVKGVIQHYPAS--PLVGFSAVVVSSVPLGGGLSSSASLEVATYTFIQQLCpdSGAIAAR-- 166
Cdd:COG0153  77 L----DDLEPGeEDGWANYVRGVAWALQERgyKLGGFDLVIDGDVPLGAGLSSSAALEVAVALALNDLF--GLGLDPVel 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102413 167 AQVCQRAEHSFAGVPCGIMDQLIALLGQKGYALLIDCRSLETSLVPLSDPKLAVLITNSNVRHSLGSSEYPVRRRQCEEV 246
Cdd:COG0153 151 AKIGQRAENEFVGVPCGIMDQFASALGKKGHALLLDCRSLEYEYVPLPLEGYALVIVDTNVKHSLADSEYNERRAECEAA 230

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102413 247 AQALGKESLREVRMEELEAGRELMSKEG-FRRARHVVSEIRRTAQAAAAMSRGDYKAFGRLMVESHYSLRDDYEVSCPEL 325
Cdd:COG0153 231 AAILGVKSLRDVTLEDLEAARARLGDEVlRRRARHVVTENQRVLEAVEALRAGDLEAFGKLMNASHASLRDDYEVSCPEL 310

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102413 326 DQLVEAALSVPGVYGSRMTGGGFGGCTVTLLEASVAPLVIDHIQEQYS----GTATFYLSQAADGAQVLS 391
Cdd:COG0153 311 DTLVELALAEAGVLGARMTGGGFGGCTIALVPKDAVDEFIEAVAEAYAektgLEPDFYVVKPSDGARRLA 380
 
Name Accession Description Interval E-value
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
12-391 7.46e-171

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 481.96  E-value: 7.46e-171
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102413  12 LLAEARRAFMEEFGAEPELAVSAPGRVNLIGEHTDYNQGLVLPMALELVTVMVGSPRTDGLVSLlttsKDADEPQRLQFP 91
Cdd:COG0153   1 RLERLIEAFEEAFGEEPEGVFSAPGRVNLIGEHTDYNGGFVLPAAIDRGTYAAARPRDDRKVRV----YSADFDEEVEFD 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102413  92 LpsaqWSLEPG-IPQWANYVKGVIQHYPAS--PLVGFSAVVVSSVPLGGGLSSSASLEVATYTFIQQLCpdSGAIAAR-- 166
Cdd:COG0153  77 L----DDLEPGeEDGWANYVRGVAWALQERgyKLGGFDLVIDGDVPLGAGLSSSAALEVAVALALNDLF--GLGLDPVel 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102413 167 AQVCQRAEHSFAGVPCGIMDQLIALLGQKGYALLIDCRSLETSLVPLSDPKLAVLITNSNVRHSLGSSEYPVRRRQCEEV 246
Cdd:COG0153 151 AKIGQRAENEFVGVPCGIMDQFASALGKKGHALLLDCRSLEYEYVPLPLEGYALVIVDTNVKHSLADSEYNERRAECEAA 230

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102413 247 AQALGKESLREVRMEELEAGRELMSKEG-FRRARHVVSEIRRTAQAAAAMSRGDYKAFGRLMVESHYSLRDDYEVSCPEL 325
Cdd:COG0153 231 AAILGVKSLRDVTLEDLEAARARLGDEVlRRRARHVVTENQRVLEAVEALRAGDLEAFGKLMNASHASLRDDYEVSCPEL 310

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102413 326 DQLVEAALSVPGVYGSRMTGGGFGGCTVTLLEASVAPLVIDHIQEQYS----GTATFYLSQAADGAQVLS 391
Cdd:COG0153 311 DTLVELALAEAGVLGARMTGGGFGGCTIALVPKDAVDEFIEAVAEAYAektgLEPDFYVVKPSDGARRLA 380
PRK05101 PRK05101
galactokinase; Provisional
 12-390 2.37e-131

galactokinase; Provisional


Pssm-ID: 179937 [Multi-domain]  Cd Length: 382  Bit Score: 381.96  E-value: 2.37e-131
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102413   12 LLAEARRAFMEEFGAEPELAVSAPGRVNLIGEHTDYNQGLVLPMALELVTVMVGSPRTDGLVSLLTtskdAD-EPQRLQF 90
Cdd:PRK05101   3 LKQKTQSLFAQQFGYPPTHTIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISCAKRDDRIVRVIA----ADyDNQQDEF 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102413   91 PLPsaqwslEPGIPQ----WANYVKGVIQHYPAS--PLVGFSAVVVSSVPLGGGLSSSASLEVATYTFIQQL--CPDSGA 162
Cdd:PRK05101  79 SLD------APIVPHpeqqWANYVRGVVKHLQERnpDFGGADLVISGNVPQGAGLSSSASLEVAVGQTFQQLyhLPLSGA 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102413  163 IAARaqVCQRAEHSFAGVPCGIMDQLIALLGQKGYALLIDCRSLETSLVPLsdPK-LAVLITNSNVRHSLGSSEYPVRRR 241
Cdd:PRK05101 153 EIAL--NGQEAENQFVGCNCGIMDQLISALGKKDHALLIDCRSLETKAVPM--PEgVAVVIINSNVKRGLVDSEYNTRRQ 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102413  242 QCEEVAQALGKESLREVRMEELEAGRELMSKEGFRRARHVVSEIRRTAQAAAAMSRGDYKAFGRLMVESHYSLRDDYEVS 321
Cdd:PRK05101 229 QCETAARFFGVKALRDVTLEQFNAVAAELDPVVAKRARHVITENARTLEAASALAAGDLKRMGELMAESHASMRDDFEIT 308

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 93102413  322 CPELDQLVEAALSVPGVYGS-RMTGGGFGGCTVTLLEASVAPLVIDHIQEQYSGT----ATFYLSQAADGAQVL 390
Cdd:PRK05101 309 VPQIDTLVEIVKAVIGDQGGvRMTGGGFGGCIVALVPEELVEAVRQAVAEQYEAKtglkETFYVCKASQGAGQC 382
gal_kin TIGR00131
galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, ...
 15-390 3.68e-121

galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.The galactokinases found by this model are divided into two sets. Prokaryotic forms are generally shorter. The eukaryotic forms are longer because of additional central regions and in some cases are known to be bifunctional, with regulatory activities that are independent of galactokinase activity. [Energy metabolism, Sugars]


Pssm-ID: 272924 [Multi-domain]  Cd Length: 386  Bit Score: 356.06  E-value: 3.68e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102413    15 EARRAFMEEFGAEPELAVSAPGRVNLIGEHTDYNQGLVLPMALELVTVMVGSPRTDGLVSLLTTSKDADEPQR-LQFPLP 93
Cdd:TIGR00131   3 SIQKIFASAFGAKPDFTARAPGRVNLIGEHTDYNDGSVLPCAIDFGTLCAVAVRDDKNVRIYLANADNKFAERsLDLPLD 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102413    94 SAQWSlepgipQWANYVKGVIQH----YPASPLvGFSAVVVSSVPLGGGLSSSASLEVATYTFIQQLCP---DSGAIAAR 166
Cdd:TIGR00131  83 GSEVS------DWANYFKGVLHVaqerFNSFPL-GADIVCSGNVPTGSGLSSSAAFECAVGAVLQNMGHlplDSKQILLR 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102413   167 AQVcqrAEHSFAGVPCGIMDQLIALLGQKGYALLIDCRSLETSLVPLSDPKLAVLITNSNVRHSLGSSEYPVRRRQCEEV 246
Cdd:TIGR00131 156 IQV---AENHFVGVNCGIMDQAASVLGKEDHALLVECRSLKATPFKFPQLGIAFVIANTNVKRTLAPSNYNTRRQECTTA 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102413   247 AQALGKES---LREVRMEELEAGRE---LMSKEGFRRARHVVSEIRRTAQAAAAMSRGDYKAFGRLMVESHYSLRDDYEV 320
Cdd:TIGR00131 233 ANFLAATDkgaLRDFMNEYFARYIArltKMLPLVEERAKHVVSENLRVLKAVKAMKDNDFKQFGALMNESHASCDDDYEC 312

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 93102413   321 SCPELDQLVEAALSVPGVYGSRMTGGGFGGCTVTLLEASVAPLVIDHIQEQYSGT----ATFYLSQAADGAQVL 390
Cdd:TIGR00131 313 TCPEIDELVCSAALVNGSGGSRMTGAGFGGCTVHLVPNENVDKVRQAVADKYPKKtgleLTFYVIVSKPGAGSC 386
GalKase_gal_bdg pfam10509
Galactokinase galactose-binding signature; This is the highly conserved galactokinase ...
 19-67 2.86e-23

Galactokinase galactose-binding signature; This is the highly conserved galactokinase signature sequence which appears to be present in all galactokinases irrespective of how many other ATP binding sites, etc that they carry. The function of this domain appears to be to bind galactose, and the domain is normally at the N-terminus of the enzymes, EC:2.7.1.6. This domain is associated with the families GHMP_kinases_C, pfam08544 and GHMP_kinases_N, pfam00288.


Pssm-ID: 463125 [Multi-domain]  Cd Length: 50  Bit Score: 91.36  E-value: 2.86e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 93102413    19 AFMEEFGAEPELAVSAPGRVNLIGEHTDYNQGLVLPMALELVTVMVGSP 67
Cdd:pfam10509   2 AFEELFGKEPVGVASAPGRVNLIGEHTDYNGGFVLPAAINLDTYVAVSP 50
 
Name Accession Description Interval E-value
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
12-391 7.46e-171

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 481.96  E-value: 7.46e-171
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102413  12 LLAEARRAFMEEFGAEPELAVSAPGRVNLIGEHTDYNQGLVLPMALELVTVMVGSPRTDGLVSLlttsKDADEPQRLQFP 91
Cdd:COG0153   1 RLERLIEAFEEAFGEEPEGVFSAPGRVNLIGEHTDYNGGFVLPAAIDRGTYAAARPRDDRKVRV----YSADFDEEVEFD 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102413  92 LpsaqWSLEPG-IPQWANYVKGVIQHYPAS--PLVGFSAVVVSSVPLGGGLSSSASLEVATYTFIQQLCpdSGAIAAR-- 166
Cdd:COG0153  77 L----DDLEPGeEDGWANYVRGVAWALQERgyKLGGFDLVIDGDVPLGAGLSSSAALEVAVALALNDLF--GLGLDPVel 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102413 167 AQVCQRAEHSFAGVPCGIMDQLIALLGQKGYALLIDCRSLETSLVPLSDPKLAVLITNSNVRHSLGSSEYPVRRRQCEEV 246
Cdd:COG0153 151 AKIGQRAENEFVGVPCGIMDQFASALGKKGHALLLDCRSLEYEYVPLPLEGYALVIVDTNVKHSLADSEYNERRAECEAA 230

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102413 247 AQALGKESLREVRMEELEAGRELMSKEG-FRRARHVVSEIRRTAQAAAAMSRGDYKAFGRLMVESHYSLRDDYEVSCPEL 325
Cdd:COG0153 231 AAILGVKSLRDVTLEDLEAARARLGDEVlRRRARHVVTENQRVLEAVEALRAGDLEAFGKLMNASHASLRDDYEVSCPEL 310

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102413 326 DQLVEAALSVPGVYGSRMTGGGFGGCTVTLLEASVAPLVIDHIQEQYS----GTATFYLSQAADGAQVLS 391
Cdd:COG0153 311 DTLVELALAEAGVLGARMTGGGFGGCTIALVPKDAVDEFIEAVAEAYAektgLEPDFYVVKPSDGARRLA 380
PRK05101 PRK05101
galactokinase; Provisional
 12-390 2.37e-131

galactokinase; Provisional


Pssm-ID: 179937 [Multi-domain]  Cd Length: 382  Bit Score: 381.96  E-value: 2.37e-131
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102413   12 LLAEARRAFMEEFGAEPELAVSAPGRVNLIGEHTDYNQGLVLPMALELVTVMVGSPRTDGLVSLLTtskdAD-EPQRLQF 90
Cdd:PRK05101   3 LKQKTQSLFAQQFGYPPTHTIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISCAKRDDRIVRVIA----ADyDNQQDEF 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102413   91 PLPsaqwslEPGIPQ----WANYVKGVIQHYPAS--PLVGFSAVVVSSVPLGGGLSSSASLEVATYTFIQQL--CPDSGA 162
Cdd:PRK05101  79 SLD------APIVPHpeqqWANYVRGVVKHLQERnpDFGGADLVISGNVPQGAGLSSSASLEVAVGQTFQQLyhLPLSGA 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102413  163 IAARaqVCQRAEHSFAGVPCGIMDQLIALLGQKGYALLIDCRSLETSLVPLsdPK-LAVLITNSNVRHSLGSSEYPVRRR 241
Cdd:PRK05101 153 EIAL--NGQEAENQFVGCNCGIMDQLISALGKKDHALLIDCRSLETKAVPM--PEgVAVVIINSNVKRGLVDSEYNTRRQ 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102413  242 QCEEVAQALGKESLREVRMEELEAGRELMSKEGFRRARHVVSEIRRTAQAAAAMSRGDYKAFGRLMVESHYSLRDDYEVS 321
Cdd:PRK05101 229 QCETAARFFGVKALRDVTLEQFNAVAAELDPVVAKRARHVITENARTLEAASALAAGDLKRMGELMAESHASMRDDFEIT 308

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 93102413  322 CPELDQLVEAALSVPGVYGS-RMTGGGFGGCTVTLLEASVAPLVIDHIQEQYSGT----ATFYLSQAADGAQVL 390
Cdd:PRK05101 309 VPQIDTLVEIVKAVIGDQGGvRMTGGGFGGCIVALVPEELVEAVRQAVAEQYEAKtglkETFYVCKASQGAGQC 382
gal_kin TIGR00131
galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, ...
 15-390 3.68e-121

galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.The galactokinases found by this model are divided into two sets. Prokaryotic forms are generally shorter. The eukaryotic forms are longer because of additional central regions and in some cases are known to be bifunctional, with regulatory activities that are independent of galactokinase activity. [Energy metabolism, Sugars]


Pssm-ID: 272924 [Multi-domain]  Cd Length: 386  Bit Score: 356.06  E-value: 3.68e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102413    15 EARRAFMEEFGAEPELAVSAPGRVNLIGEHTDYNQGLVLPMALELVTVMVGSPRTDGLVSLLTTSKDADEPQR-LQFPLP 93
Cdd:TIGR00131   3 SIQKIFASAFGAKPDFTARAPGRVNLIGEHTDYNDGSVLPCAIDFGTLCAVAVRDDKNVRIYLANADNKFAERsLDLPLD 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102413    94 SAQWSlepgipQWANYVKGVIQH----YPASPLvGFSAVVVSSVPLGGGLSSSASLEVATYTFIQQLCP---DSGAIAAR 166
Cdd:TIGR00131  83 GSEVS------DWANYFKGVLHVaqerFNSFPL-GADIVCSGNVPTGSGLSSSAAFECAVGAVLQNMGHlplDSKQILLR 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102413   167 AQVcqrAEHSFAGVPCGIMDQLIALLGQKGYALLIDCRSLETSLVPLSDPKLAVLITNSNVRHSLGSSEYPVRRRQCEEV 246
Cdd:TIGR00131 156 IQV---AENHFVGVNCGIMDQAASVLGKEDHALLVECRSLKATPFKFPQLGIAFVIANTNVKRTLAPSNYNTRRQECTTA 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102413   247 AQALGKES---LREVRMEELEAGRE---LMSKEGFRRARHVVSEIRRTAQAAAAMSRGDYKAFGRLMVESHYSLRDDYEV 320
Cdd:TIGR00131 233 ANFLAATDkgaLRDFMNEYFARYIArltKMLPLVEERAKHVVSENLRVLKAVKAMKDNDFKQFGALMNESHASCDDDYEC 312

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 93102413   321 SCPELDQLVEAALSVPGVYGSRMTGGGFGGCTVTLLEASVAPLVIDHIQEQYSGT----ATFYLSQAADGAQVL 390
Cdd:TIGR00131 313 TCPEIDELVCSAALVNGSGGSRMTGAGFGGCTVHLVPNENVDKVRQAVADKYPKKtgleLTFYVIVSKPGAGSC 386
PRK05322 PRK05322
galactokinase; Provisional
 13-390 1.36e-113

galactokinase; Provisional


Pssm-ID: 235407 [Multi-domain]  Cd Length: 387  Bit Score: 336.83  E-value: 1.36e-113
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102413   13 LAEARRAFMEEFGAEPELAVSAPGRVNLIGEHTDYNQGLVLPMALELVTVMVGSPRTDGLVSLLttSKDADEPQRLQFPL 92
Cdd:PRK05322   3 KEELKKKFAEVFGEEAEDVFFSPGRINLIGEHTDYNGGHVFPAAITLGTYGAARKRDDKKVRLY--SANFEDLGIIEFDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102413   93 PSAQWSLEPGipqWANYVKGVI-----QHYPASPlvGFSAVVVSSVPLGGGLSSSASLEVATYTFIQQLCPDSGAIAARA 167
Cdd:PRK05322  81 DDLSFDKEDD---WANYPKGVLkflqeAGYKIDH--GFDILIYGNIPNGAGLSSSASIELLTGVILKDLFNLDLDRLELV 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102413  168 QVCQRAEHSFAGVPCGIMDQLIALLGQKGYALLIDCRSLETSLVPLSDPKLAVLITNSNVRHSLGSSEYPVRRRQCEEVA 247
Cdd:PRK05322 156 KLGQKTENEFIGVNSGIMDQFAIGMGKKDHAILLDCNTLEYEYVPLDLGDYVIVIMNTNKRRELADSKYNERRAECEKAL 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102413  248 QALGKE----SLREVRMEELEAGRELMSKEG-FRRARHVVSEIRRTAQAAAAMSRGDYKAFGRLMVESHYSLRDDYEVSC 322
Cdd:PRK05322 236 EELQKKldikSLGELTEEEFDEYSYLIKDETlLKRARHAVTENQRTLKAVKALKAGDLEKFGRLMNASHVSLRDDYEVTG 315

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 93102413  323 PELDQLVEAALSVPGVYGSRMTGGGFGGCTVTLLEASVAPLVIDHIQEQYSGT----ATFYLSQAADGAQVL 390
Cdd:PRK05322 316 LELDTLVEAAWKQEGVLGARMTGAGFGGCAIAIVKKDKVEAFKENVGKAYEEKigyaASFYVAEIGDGAREL 387
PRK03817 PRK03817
galactokinase; Provisional
 32-390 2.41e-100

galactokinase; Provisional


Pssm-ID: 235163 [Multi-domain]  Cd Length: 351  Bit Score: 301.53  E-value: 2.41e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102413   32 VSAPGRVNLIGEHTDYNQGLVLPMALELVTVMVGSPRTDGLVSllttSKDADEPQRLQFPlpsaqwSLEPGiPQWANYVK 111
Cdd:PRK03817   3 VKSPGRVNLIGEHTDYNDGYVLPFAINLYTFLEIEKSEKFIFY----SENFNEEKTFELD------KLEKL-NSWADYIK 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102413  112 GVI-----QHYPASPLVGFsavVVSSVPLGGGLSSSASLEVATYTFIQQLCPDSGAIAARAQVCQRAEHSFAGVPCGIMD 186
Cdd:PRK03817  72 GVIwvlekRGYEVGGVKGK---VSSNLPIGAGLSSSASLEVAVAYALNEAYNLNLSKLELALLAREAENEFVGVPCGIMD 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102413  187 QLIALLGQKGYALLIDCRSLETSLVPLSDpKLAVLITNSNVRHSLGSSEYPVRRRQCEEVAQALGKESLREVRMEELEAG 266
Cdd:PRK03817 149 QFAVAFGKKDHAIFLDTMTLEYEYVPFPE-DYEILVFDTGVKRELASSEYNERRQECEEALKILGKKSSKEVTEEDLSKL 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102413  267 RELMskegFRRARHVVSEIRRTAQAAAAMSRGDYKAFGRLMVESHYSLRDDYEVSCPELDQLVEAALSVpGVYGSRMTGG 346
Cdd:PRK03817 228 PPLL----RKRAGYVLRENERVLKVRDALKEGDIETLGELLTESHWDLADNYEVSCEELDFFVEFALEL-GAYGARLTGA 302

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 93102413  347 GFGGCTVTLLEASVAPLVIDHIQEQY----SGTATFYLSQAADGAQVL 390
Cdd:PRK03817 303 GFGGSAIALVDKGKFESIGEELLEEYkkrfGIDPKYFVVESSDGVRKI 350
PRK00555 PRK00555
galactokinase; Provisional
 34-370 5.31e-79

galactokinase; Provisional


Pssm-ID: 179063 [Multi-domain]  Cd Length: 363  Bit Score: 247.47  E-value: 5.31e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102413   34 APGRVNLIGEHTDYNQGLVLPMALELVTVMVGSPRTDGlvSLLTTSKDADEPQRLqfPLPSAqwslePG-IPQWANYVKG 112
Cdd:PRK00555   7 APGRINLIGEHTDYNLGFALPIALPQRTVVTFTPEHTD--AITASSDRADGSARI--PLDTT-----PGqVTGWAAYAAG 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102413  113 VIQ--HYPASPLVGFSAVVVSSVPLGGGLSSSASLEVATytfIQQLCPDSGAIAAR---AQVCQRAEHSFAGVPCGIMDQ 187
Cdd:PRK00555  78 VIWalRGAGHPVPGGAMSITSDVEIGSGLSSSAALECAV---LGAVGAATGTRIDRleqARLAQRAENEYVGAPTGLLDQ 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102413  188 LIALLGQKGYALLIDCRSLETSLVPLsDPK---LAVLITNSNVRHSLGSSEYPVRRRQCEEVAQALGKESLREVRMEELE 264
Cdd:PRK00555 155 LAALFGAPKTALLIDFRDLTVRPVAF-DPDaagVVLLLMDSRARHRHAGGEYAARRASCERAAADLGVSSLRAVQDRGLA 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102413  265 AGRELMSKEGFRRARHVVSEIRRTAQAAAAMSRGDYKAFGRLMVESHYSLRDDYEVSCPELDQLVEAALSVpGVYGSRMT 344
Cdd:PRK00555 234 ALGAIADPIDARRARHVLTENQRVLDFAAALADSDFTAAGQLLTASHASMRDDFEITTERIDLIADSAVRA-GALGARMT 312

                        330       340
                 ....*....|....*....|....*.
gi 93102413  345 GGGFGGCTVTLLEASVAPLVIDHIQE 370
Cdd:PRK00555 313 GGGFGGCVIALVPADRAEDVADTVRR 338
PLN02521 PLN02521
galactokinase
 12-372 1.77e-51

galactokinase


Pssm-ID: 215285 [Multi-domain]  Cd Length: 497  Bit Score: 179.52  E-value: 1.77e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102413   12 LLAEARR-------AFMEEFGAEPELAVSAPGRVNLIGEHTDYNQGLVLPMALELVTVMvgSPRTDGLVSLLTTSKDADE 84
Cdd:PLN02521  24 LLEEARLryarlkaAFVEVYGAKPDLFARSPGRVNLIGEHIDYEGYSVLPMAIRQDTIV--AIRRAEGSKKLRIANVNDK 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102413   85 PQRLQFPLPSAQwSLEPGIPQWANYV----KGVIQHYPAS-----PLVGFSAVVVSSVPLGGGLSSSASLEVATYTFIQ- 154
Cdd:PLN02521 102 YTTCTFPADPDQ-EVDLANHKWGNYFicgyKGVFEFLKSKgvdvgPPVGLDVVVDGTVPTGSGLSSSAALVCSAAIAIMa 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102413  155 --QLCPDSGAIAARAQVCQRaeHSfaGVPCGIMDQLIALLGQKGYALLIDCRSLETSLVPLsdPKLAVLItnsnVRHSLG 232
Cdd:PLN02521 181 alGLNFTKKEVAQFTCKCER--HI--GTQSGGMDQAISIMAQQGVAKLIDFNPVRATDVQL--PAGGTFV----IANSLA 250

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102413  233 SSE--------YPVRRRQCEEVAQALG-------KESLREVRM-----------------------------------EE 262
Cdd:PLN02521 251 ESNkavtaatnYNNRVVECRLAAIVLAvklgmsaEEAISKVKTlsdveglcvsfagshgssdpavavkellhegpytaEE 330

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102413  263 LEA--GRELMS--------------KEGFR---RARHVVSEIRRTAQ--AAAAMSRGDY---KAFGRLMVESHYSLRDDY 318
Cdd:PLN02521 331 IEEilGESLTSifknsptslavlkaAKHFKlhqRAVHVYSEAKRVHAfrDTVSSSLSEEeklKKLGDLMNESHYSCSVLY 410

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....
gi 93102413  319 EVSCPELDQLVEAALSvPGVYGSRMTGGGFGGCTVTLLEASVAPLVIDHIQEQY 372
Cdd:PLN02521 411 ECSCPELEELVKVCRD-NGALGARLTGAGWGGCAVALVKEAIVPQFILALKEKF 463
PTZ00290 PTZ00290
galactokinase; Provisional
 8-392 8.76e-47

galactokinase; Provisional


Pssm-ID: 240347 [Multi-domain]  Cd Length: 468  Bit Score: 166.15  E-value: 8.76e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102413    8 RVEELLAEARRAFMEEFGAEPELAVS------APGRVNLIGEHTDYNQGLVLPMA-LELVTVMVGSPR--TDGLVSLLTT 78
Cdd:PTZ00290  10 RLDSTLSTLKPIFLETFKVENDADVEwllftfAPGRVNFIGEHVDYMGGYVCPAAvLEGCHILVGRVKhfCDHKLRFATE 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102413   79 SKDADEPQRLQFPLPSAQWSlepgipqwaNYVKGVIQ--------HYPASPLVGFSAVVVSSVPLGGGLSSSASLEVA-- 148
Cdd:PTZ00290  90 TDEHFVLDHLGGAKHNKAWT---------TFVRGAATlrlnrlgvAIDAPSLQGVCMVVHGTLPMGAGMSASASFGVAll 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102413  149 -----TYTFIQQLCPDSG----AIAAR---------AQVCQRAEHSFAGVPCGIMDQLIALLGQKGYALLIDCRSLETSL 210
Cdd:PTZ00290 161 naintVVTRRYKGCPTSPgrrySILPPmskeelielAKQARRIETEFCGVNVGIMDQFISAFAEEDKFMFLDCKSLTFES 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102413  211 VPLSdPKL----AVLITNSNVRHSL-GSSE--YPVRRRQCEEVAQALGKESLRE--------VRMEE-----------LE 264
Cdd:PTZ00290 241 HDMT-PLLgdgaCFLLIDSMIKHDLlGGTAgmYNTVRSDQEGAQKKIGKHRYRGkpftfsdlVRNPKkytfdgdvvafME 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102413  265 AGRELMSKEGFRRARHVVSEIRRTAQ------AAAAMSRGD-YKAFGRLMVESHYSLRDDYEVSCPELDQLVEAALSVPG 337
Cdd:PTZ00290 320 SCKPLMTPGEFERGTYNIMEQIRTLEfiklndPELPLSREErFRKAGEILNAGHQGMRDLMKITTPELDFIHELINEEKG 399

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 93102413  338 VYGSRMTGGGFGGCTVTLLEASVAPLVIDHIQEQYSG----TATFYLSQAADGAQVLSL 392
Cdd:PTZ00290 400 VAGGRMMGGGFGGCIILLLKKNAVDRVVAHVREKFKArfgvENDVYPVVAGDGAFVVSL 458
PLN02865 PLN02865
galactokinase
 10-372 1.46e-43

galactokinase


Pssm-ID: 215466 [Multi-domain]  Cd Length: 423  Bit Score: 156.50  E-value: 1.46e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102413   10 EELLAEARRAFMEEFGAEPE--LAVSAPGRVNLIGEHTDYNQGLVLPMALELvTVMVGSPRTDGLVSLLTTSKDADEPQ- 86
Cdd:PLN02865   9 ANELDEIRERVAAMSGRNSGevRVVVSPYRICPLGAHIDHQGGTVSAMTINK-GILLGFVPSGDPEVLLRSAQFEGEVRf 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102413   87 ---RLQFPLPSAQWSLEPGIpQWANYVKGVI---QHYPASPLVGFSAVVVSSVPL-GGGLSSSASLEVATYTFIQQLCPD 159
Cdd:PLN02865  88 rvdEIQHPIANVSSDSKEES-NWGDYARGAVyalQSRGHALSQGITGYISGSEGLdSSGLSSSAAVGVAYLLALENANNL 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102413  160 SGAIAARAQVCQRAEHSFAGVPCGIMDQLIALLGQKGYALLIDCRSLETSLVPLSDPK------LAVLITNSNVRHSLGS 233
Cdd:PLN02865 167 TVSPEDNIELDRLIENEYLGLRNGILDQSAILLSRYGCLTFMDCKTLDHKLVSLQFQQpggekpFKILLAFSGLRHALTN 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102413  234 SE-YPVRRRQCEEVAQALGKES--------LREVRMEELEAGRELMSKEGFRRARHVVSEIRRTAQAAAAMSRGDYKAFG 304
Cdd:PLN02865 247 KPgYNLRVSECQEAARFLLEASgndeleplLCNVEPEVYEAHKCKLEAVLARRAEHYFSENMRVIKGVEAWASGNLEEFG 326

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 93102413  305 RLMVESHYSLRDDYEVSCPELDQLVEAALSVPGVYGSRMTGGGFGGCTVTLLEASVAPLVIDHIQEQY 372
Cdd:PLN02865 327 KLISASGLSSIENYECGCEPLIQLYEILLKAPGVYGARFSGAGFRGCCVAFVDAEMAEEAASFVRDEY 394
GalKase_gal_bdg pfam10509
Galactokinase galactose-binding signature; This is the highly conserved galactokinase ...
 19-67 2.86e-23

Galactokinase galactose-binding signature; This is the highly conserved galactokinase signature sequence which appears to be present in all galactokinases irrespective of how many other ATP binding sites, etc that they carry. The function of this domain appears to be to bind galactose, and the domain is normally at the N-terminus of the enzymes, EC:2.7.1.6. This domain is associated with the families GHMP_kinases_C, pfam08544 and GHMP_kinases_N, pfam00288.


Pssm-ID: 463125 [Multi-domain]  Cd Length: 50  Bit Score: 91.36  E-value: 2.86e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 93102413    19 AFMEEFGAEPELAVSAPGRVNLIGEHTDYNQGLVLPMALELVTVMVGSP 67
Cdd:pfam10509   2 AFEELFGKEPVGVASAPGRVNLIGEHTDYNGGFVLPAAINLDTYVAVSP 50
ERG12 COG1577
Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway ...
 34-355 2.94e-21

Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441185 [Multi-domain]  Cd Length: 277  Bit Score: 92.60  E-value: 2.94e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102413  34 APGRVNLIGEHTD-YNQGlVLPMALEL-VTVMVgSPRTDGLVSLlttskdadEPQRLQFPlpsaqWSLEPGIPQWANYVK 111
Cdd:COG1577   1 APGKLILFGEHAVvYGQP-AIAVAVDRrATVTV-EPSDDDKLRI--------ESPDLGGT-----LDLDPLADAALRYIK 65

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102413 112 GVIQ---HYPASPLVGFSAVVVSSVPLGGGLSSSASLEVATYTFIQQLC---PDSGAIAARAQVCQRAEHsfaGVPCGiM 185
Cdd:COG1577  66 AAIEaalEYLGLPLKGFDIEIDSEIPRKRGLGSSAAVAVAVIRALAAFYgveLSKEELFKLALEAEKIVH---GNPSG-L 141

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102413 186 DQLIALLGQkgyALLIDCRSLETSLVPlsDPKLAVLITNSNVRHSlgsseypvrrrqceevaqalGKESLREVRmeelea 265
Cdd:COG1577 142 DTAASTYGG---PIYYQRGDRAEPLEL--PKNLPLVVGDTGVPAS--------------------TKELVAKVR------ 190

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102413 266 grELMSKEGFRrARHVVSEIRR-TAQAAAAMSRGDYKAFGRLMVESHySLRDDYEVSCPELDQLVEAALSvPGVYGSRMT 344
Cdd:COG1577 191 --KLKERNPEL-YEAFLEEIGDlVEEAIEALEEGDLEALGELMNENH-GLLRALGVSTPELDRLVEAARK-AGALGAKLT 265

                       330
                ....*....|.
gi 93102413 345 GGGFGGCTVTL 355
Cdd:COG1577 266 GAGGGGCVIAL 276
mevalon_kin TIGR00549
mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate ...
 34-355 3.71e-19

mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate pathway of isopentanyl pyrophosphate (IPP) biosynthesis. IPP is a common intermediate for a number of pathways including cholesterol biosynthesis. This model covers enzymes from eukaryotes, archaea and bacteria. The related enzyme from the same pathway, phosphmevalonate kinase, serves as an outgroup for this clade. Paracoccus exhibits two genes within the phosphomevalonate/mevalonate kinase family, one of which falls between trusted and noise cutoffs of this model. The degree of divergence is high, but if the trees created from this model are correct, the proper names of these genes have been swapped. [Central intermediary metabolism, Other]


Pssm-ID: 273130 [Multi-domain]  Cd Length: 273  Bit Score: 86.58  E-value: 3.71e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102413    34 APGRVNLIGEHTD-YNQ-GLVLPMALELVTVMVGSPRTDGLVSLLTTSKDADEPQRLQfplpsaqwslepGIPqwanYVK 111
Cdd:TIGR00549   1 APGKIILFGEHAVvYGEpAIAAPIPLRTTVTVIESSDGSFIESDLGRGSLDDAPDELD------------GLK----YVL 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102413   112 GVIQHYPAS-PLVGFSAVVVSSVPLGGGLSSSASLEVATYTFIQQLCPDSGAIAARAQVCQRAEHSFAGVPCGImDQLIA 190
Cdd:TIGR00549  65 AEFLSRFSElNPPPLEITIESEIPPGRGLGSSAAVAVALIRALADYFGSELSKEELAELANEAEKIAHGKPSGI-DTATS 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102413   191 LLGqkgYALLIDCRSLETSLvpLSDPKLAVLITNSNVRHSlgsseypvRRRQCEEVAQalGKESLREVRMEELEAGRELm 270
Cdd:TIGR00549 144 TSG---GPVYFEKGEGEFTK--LISLDGYFVIADTGVSGS--------TKEAVARVRQ--LLERFPELIDSIMDAIGEL- 207

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102413   271 skegfrrarhvvseirrTAQAAAAMSRGDYKAFGRLMVESHySLRDDYEVSCPELDQLVEAALSVpGVYGSRMTGGGFGG 350
Cdd:TIGR00549 208 -----------------TLEAKAALQDGDVESLGELMNINQ-GLLKALGVSHPKLDQLVEIARKA-GALGAKLTGAGGGG 268


                  ....*
gi 93102413   351 CTVTL 355
Cdd:TIGR00549 269 CMIAL 273
PRK03926 PRK03926
mevalonate kinase; Provisional
 33-355 4.67e-11

mevalonate kinase; Provisional


Pssm-ID: 179677 [Multi-domain]  Cd Length: 302  Bit Score: 63.15  E-value: 4.67e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102413   33 SAPGRVNLIGEHTDYNQGLVLPMALELVTVMVGSPRTDGLVsllTTSKDADEPQRLqfplpsaqwslepgipqwaNYVKG 112
Cdd:PRK03926   5 SAPGKIYLFGEHAVVYGKPAIACAIDLRTYVRAEFNDDSIY---IESDYGKTGEKH-------------------PYVSA 62

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102413  113 VIQHY-PASPLVGFSAVVVSSVPLGGGLSSSASLEVATYTFIQQLCPDSGAIAARAQVCQRAEHSFAGVPCGImDQLIAL 191
Cdd:PRK03926  63 AIEKMrEEADKDGVTVSITSQIPVGSGLGSSAAVTVATIGALNRLLGLGLSLEEIAKLGHKVELLVQGAASPT-DTYVST 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102413  192 LGqkGYALLIDCRSLETslvplsdPKLAVLITNSNVRHSLGSSEYPVRRrqceevaqalgkesLREvRMEELEAGreLMS 271
Cdd:PRK03926 142 MG--GFVTIPDRKKLPF-------PECGIVVGYTGSSGSTKELVANVRK--------------LKE-EYPELIEP--ILS 195

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102413  272 KEGfrrarhvvseiRRTAQAAAAMSRGDYKAFGRLMVESHySLRDDYEVSCPELDQLVEAALSVpGVYGSRMTGGGFGGC 351
Cdd:PRK03926 196 SIG-----------KISEKGEELILSGDYVSLGELMNINQ-GLLDALGVSTKELSELIYAARTA-GALGAKITGAGGGGC 262


                 ....
gi 93102413  352 TVTL 355
Cdd:PRK03926 263 MVAL 266
GHMP_kinases_N pfam00288
GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and ...
 128-193 5.00e-10

GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 395225 [Multi-domain]  Cd Length: 64  Bit Score: 54.86  E-value: 5.00e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 93102413   128 VVVSSVPLGGGLSSSASLEVATYTFIQQLCPDSgaiaaRAQVCQRAEHSFAGVPCGIMDQLIALLG 193
Cdd:pfam00288   3 EIESNIPLGAGLGSSAALAVALLLALNELFGLP-----LAKLALEAEELAGGGRGGGMDVAASLYG 63
GHMP_kinases_C pfam08544
GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and ...
 291-373 2.81e-09

GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 430063 [Multi-domain]  Cd Length: 85  Bit Score: 53.63  E-value: 2.81e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102413   291 AAAAMSRGDYKAFGRLMVESHYSL--RDDYEVSCPELDQLVEAALSVpgVYGSRMTGGGFGGCTVTLLE-ASVAPLVIDH 367
Cdd:pfam08544   1 LLEALLRGDLEELGKLLTESAESLepLLVVGILPPELDELLEALLEL--GLGAKLSGSGGGPTVFALFKdEDDAEEVARA 78


                  ....*.
gi 93102413   368 IQEQYS 373
Cdd:pfam08544  79 LREAGK 84
PTZ00298 PTZ00298
mevalonate kinase; Provisional
 275-355 2.38e-05

mevalonate kinase; Provisional


Pssm-ID: 240351 [Multi-domain]  Cd Length: 328  Bit Score: 46.00  E-value: 2.38e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102413  275 FRRARHVVSeirrtaQAAAAMSRGDYKAFGRLMVESHySLRDDYEVSCPELDQLVEAALSVpGVYGSRMTGGGFGGCTVT 354
Cdd:PTZ00298 220 LENYNACVS------EAKEALQKGNLFRVGELMNANH-DLCQKLTVSCRELDSIVQTCRTY-GALGAKMSGTGRGGLVVA 291


                 .
gi 93102413  355 L 355
Cdd:PTZ00298 292 L 292
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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