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RWD domain-containing protein 2B isoform 1 [Homo sapiens]
RWD domain-containing protein( domain architecture ID 10530624)
RWD domain-containing protein containing a small nuclear ribonucleoprotein Prp3 C-terminal domain domain (formerly DUF1115), similar to RWD domain-containing protein 2A/2B
List of domain hits
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Name | Accession | Description | Interval | E-value | |||
RWDD2_C | cd24163 | C-terminal domain of RWD domain-containing protein 2; RWDD2A, as well as RWDD2B, are small ... |
187-315 | 3.79e-57 | |||
C-terminal domain of RWD domain-containing protein 2; RWDD2A, as well as RWDD2B, are small proteins that contain an N-terminal RWD domain and a C-terminal domain of unknown function. The C-terminal domain is predicted (by AlphaFold) to adopt a fold similar to the C-terminal domain of Prp3, an essential U4/U6 di-snRNP-associated protein which plays a role in pre-mRNA splicing. The Prp3 C-terminal domain is a single-stranded RNA-binding domain. : Pssm-ID: 467814 Cd Length: 122 Bit Score: 180.53 E-value: 3.79e-57
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RWD_RWDD2 | cd23829 | RWD domain of RWD domain-containing protein 2A (RWDD2A), 2B (RWDD2B) and related proteins; ... |
35-166 | 6.89e-54 | |||
RWD domain of RWD domain-containing protein 2A (RWDD2A), 2B (RWDD2B) and related proteins; This subfamily includes RWDD2A, previously known as RWD domain-containing 2 (RWDD2) and RWDD2B, previously known in humans as chromosome 21 open reading frame (C21orf6). C21orf6 appears to be involved in monosomy 21 phenotype. The RWD domain may mediate protein-protein interactions. : Pssm-ID: 467663 Cd Length: 129 Bit Score: 172.37 E-value: 6.89e-54
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Name | Accession | Description | Interval | E-value | |||
RWDD2_C | cd24163 | C-terminal domain of RWD domain-containing protein 2; RWDD2A, as well as RWDD2B, are small ... |
187-315 | 3.79e-57 | |||
C-terminal domain of RWD domain-containing protein 2; RWDD2A, as well as RWDD2B, are small proteins that contain an N-terminal RWD domain and a C-terminal domain of unknown function. The C-terminal domain is predicted (by AlphaFold) to adopt a fold similar to the C-terminal domain of Prp3, an essential U4/U6 di-snRNP-associated protein which plays a role in pre-mRNA splicing. The Prp3 C-terminal domain is a single-stranded RNA-binding domain. Pssm-ID: 467814 Cd Length: 122 Bit Score: 180.53 E-value: 3.79e-57
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RWD_RWDD2 | cd23829 | RWD domain of RWD domain-containing protein 2A (RWDD2A), 2B (RWDD2B) and related proteins; ... |
35-166 | 6.89e-54 | |||
RWD domain of RWD domain-containing protein 2A (RWDD2A), 2B (RWDD2B) and related proteins; This subfamily includes RWDD2A, previously known as RWD domain-containing 2 (RWDD2) and RWDD2B, previously known in humans as chromosome 21 open reading frame (C21orf6). C21orf6 appears to be involved in monosomy 21 phenotype. The RWD domain may mediate protein-protein interactions. Pssm-ID: 467663 Cd Length: 129 Bit Score: 172.37 E-value: 6.89e-54
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DUF1115 | pfam06544 | Protein of unknown function (DUF1115); This family represents the C-terminus of hypothetical ... |
190-312 | 1.89e-21 | |||
Protein of unknown function (DUF1115); This family represents the C-terminus of hypothetical eukaryotic proteins of unknown function. Pssm-ID: 461943 Cd Length: 135 Bit Score: 88.12 E-value: 1.89e-21
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RWD | pfam05773 | RWD domain; This domain was identified in WD40 repeat proteins and Ring finger domain proteins. ... |
37-162 | 3.15e-14 | |||
RWD domain; This domain was identified in WD40 repeat proteins and Ring finger domain proteins. The function of this domain is unknown. GCN2 is the alpha-subunit of the only translation initiation factor (eIF2 alpha) kinase that appears in all eukaryotes. Its function requires an interaction with GCN1 via the domain at its N-terminus, which is termed the RWD domain after three major RWD-containing proteins: RING finger-containing proteins, WD-repeat-containing proteins, and yeast DEAD (DEXD)-like helicases. The structure forms an alpha + beta sandwich fold consisting of two layers: a four-stranded antiparallel beta-sheet, and three side-by-side alpha-helices. Pssm-ID: 399058 Cd Length: 111 Bit Score: 67.73 E-value: 3.15e-14
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RWD | smart00591 | domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily ... |
42-165 | 1.93e-13 | |||
domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain; Pssm-ID: 214735 Cd Length: 107 Bit Score: 65.46 E-value: 1.93e-13
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PRK14422 | PRK14422 | acylphosphatase; Provisional |
210-244 | 2.48e-03 | |||
acylphosphatase; Provisional Pssm-ID: 237712 Cd Length: 93 Bit Score: 36.64 E-value: 2.48e-03
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Name | Accession | Description | Interval | E-value | |||
RWDD2_C | cd24163 | C-terminal domain of RWD domain-containing protein 2; RWDD2A, as well as RWDD2B, are small ... |
187-315 | 3.79e-57 | |||
C-terminal domain of RWD domain-containing protein 2; RWDD2A, as well as RWDD2B, are small proteins that contain an N-terminal RWD domain and a C-terminal domain of unknown function. The C-terminal domain is predicted (by AlphaFold) to adopt a fold similar to the C-terminal domain of Prp3, an essential U4/U6 di-snRNP-associated protein which plays a role in pre-mRNA splicing. The Prp3 C-terminal domain is a single-stranded RNA-binding domain. Pssm-ID: 467814 Cd Length: 122 Bit Score: 180.53 E-value: 3.79e-57
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RWD_RWDD2 | cd23829 | RWD domain of RWD domain-containing protein 2A (RWDD2A), 2B (RWDD2B) and related proteins; ... |
35-166 | 6.89e-54 | |||
RWD domain of RWD domain-containing protein 2A (RWDD2A), 2B (RWDD2B) and related proteins; This subfamily includes RWDD2A, previously known as RWD domain-containing 2 (RWDD2) and RWDD2B, previously known in humans as chromosome 21 open reading frame (C21orf6). C21orf6 appears to be involved in monosomy 21 phenotype. The RWD domain may mediate protein-protein interactions. Pssm-ID: 467663 Cd Length: 129 Bit Score: 172.37 E-value: 6.89e-54
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Prp3_C-like | cd24140 | C-terminal domain of Prp3 and related proteins; This group contains the C-terminal domains of ... |
187-315 | 1.49e-29 | |||
C-terminal domain of Prp3 and related proteins; This group contains the C-terminal domains of Prp3 and RWD domain-containing proteins 2/3. Predicted structures (by AlphaFold) of the C-terminal domains of RWDD2 and RWDD3 reveal similarity to the C-terminal domain of Prp3, an essential U4/U6 di-snRNP-associated protein which plays a role in pre-mRNA splicing. The Prp3 C-terminal domain is a single-stranded RNA-binding domain. Pssm-ID: 467812 Cd Length: 117 Bit Score: 109.27 E-value: 1.49e-29
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DUF1115 | pfam06544 | Protein of unknown function (DUF1115); This family represents the C-terminus of hypothetical ... |
190-312 | 1.89e-21 | |||
Protein of unknown function (DUF1115); This family represents the C-terminus of hypothetical eukaryotic proteins of unknown function. Pssm-ID: 461943 Cd Length: 135 Bit Score: 88.12 E-value: 1.89e-21
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RWD | pfam05773 | RWD domain; This domain was identified in WD40 repeat proteins and Ring finger domain proteins. ... |
37-162 | 3.15e-14 | |||
RWD domain; This domain was identified in WD40 repeat proteins and Ring finger domain proteins. The function of this domain is unknown. GCN2 is the alpha-subunit of the only translation initiation factor (eIF2 alpha) kinase that appears in all eukaryotes. Its function requires an interaction with GCN1 via the domain at its N-terminus, which is termed the RWD domain after three major RWD-containing proteins: RING finger-containing proteins, WD-repeat-containing proteins, and yeast DEAD (DEXD)-like helicases. The structure forms an alpha + beta sandwich fold consisting of two layers: a four-stranded antiparallel beta-sheet, and three side-by-side alpha-helices. Pssm-ID: 399058 Cd Length: 111 Bit Score: 67.73 E-value: 3.15e-14
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RWD | smart00591 | domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily ... |
42-165 | 1.93e-13 | |||
domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain; Pssm-ID: 214735 Cd Length: 107 Bit Score: 65.46 E-value: 1.93e-13
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RWD_RWDD3 | cd23819 | RWD domain of RWD domain-containing protein 3 (RWDD3) and related proteins; RWDD3, also called ... |
42-161 | 2.50e-12 | |||
RWD domain of RWD domain-containing protein 3 (RWDD3) and related proteins; RWDD3, also called RWD domain-containing sumoylation enhancer (RSUME), acts as an enhancer of SUMO conjugation and has no effect on ubiquitination. It increases protein sumoylation (a dynamic ubiquitin-like post translational modification) of several proteins including HIF1alpha and I-kappa-B, through direct interaction with UBC9. Its RWD domain is required for the sumoylation enhancement activity. Pssm-ID: 467655 Cd Length: 106 Bit Score: 62.34 E-value: 2.50e-12
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RWD_DRWD_ELF-like | cd11605 | RWD, DRWD, and ELF domain family; The family includes the RWD, double-RWD (DRWD), and ELF ... |
45-158 | 6.01e-06 | |||
RWD, DRWD, and ELF domain family; The family includes the RWD, double-RWD (DRWD), and ELF domains. They belong to the ubiquitin-conjugating (UBC) superfamily that represents a structural domain with an alpha-beta(4)-alpha(3) core fold. The RWD domain (named after three major RWD-containing proteins: RING finger, WD-repeat-containing proteins and DEXD-like helicases) mediates protein-protein interactions in a variety of pathways in eukaryotes. The DRWD domain is responsible for substrate binding. It is involved in interactions with other kinetochore proteins. The ELF (N-terminal E2-like fold) domain is found in all Fanconi anemia group L protein (FANCL) homologs. It is required to promote efficient DNA damage-induced FANCD2 (Fanconi anemia group D2 protein) monoubiquitination in vertebrate cells. Pssm-ID: 467641 Cd Length: 94 Bit Score: 44.10 E-value: 6.01e-06
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RWD_GCN2 | cd23823 | RWD domain of eIF-2-alpha kinase GCN2 and related proteins; GCN2 (EC 2.7.11.1), also called ... |
36-160 | 2.50e-04 | |||
RWD domain of eIF-2-alpha kinase GCN2 and related proteins; GCN2 (EC 2.7.11.1), also called eukaryotic translation initiation factor 2-alpha kinase 4 (EIF2AK4), acts as a metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to low amino acid availability. It also plays a role in modulating the adaptive immune response to yellow fever virus infection and promotes dendritic cells to initiate autophagy and antigene presentation to both CD4(+) and CD8(+) T-cells under amino acid starvation. Pssm-ID: 467659 Cd Length: 117 Bit Score: 39.89 E-value: 2.50e-04
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PRK14422 | PRK14422 | acylphosphatase; Provisional |
210-244 | 2.48e-03 | |||
acylphosphatase; Provisional Pssm-ID: 237712 Cd Length: 93 Bit Score: 36.64 E-value: 2.48e-03
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RWD_RNF25 | cd23818 | RWD domain of RING finger protein 25 (RNF25) and related proteins; RNF25 (EC 2.3.2.27), also ... |
42-161 | 9.32e-03 | |||
RWD domain of RING finger protein 25 (RNF25) and related proteins; RNF25 (EC 2.3.2.27), also known as AO7, is a putative E3 ubiquitin-protein ligase that was initially identified as an interacting protein of the E2 ubiquitin-conjugating enzyme, Ubc5B. It is ubiquitously expressed in various tissues and is predominantly localized in the nucleus. RNF25 activates nuclear factor (NF)-kappaB-dependent gene expression upon stimulation with interleukin-1 beta (IL-1beta), or tumor necrosis factor (TNF), or overexpression of NF-kappaB-inducing kinase. It interacts with the p65 transactivation domain (TAD) and modulates its transcriptional activity. Pssm-ID: 467654 Cd Length: 109 Bit Score: 35.21 E-value: 9.32e-03
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Blast search parameters | ||||
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