NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|8393018|ref|NP_058636|]
View 

RWD domain-containing protein 2B isoform 1 [Homo sapiens]

Protein Classification

RWD domain-containing protein( domain architecture ID 10530624)

RWD domain-containing protein containing a small nuclear ribonucleoprotein Prp3 C-terminal domain domain (formerly DUF1115), similar to RWD domain-containing protein 2A/2B

CATH:  3.10.110.10
Gene Ontology:  GO:0005515
PubMed:  26276859|25918163

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
RWDD2_C cd24163
C-terminal domain of RWD domain-containing protein 2; RWDD2A, as well as RWDD2B, are small ...
 187-315 3.79e-57

C-terminal domain of RWD domain-containing protein 2; RWDD2A, as well as RWDD2B, are small proteins that contain an N-terminal RWD domain and a C-terminal domain of unknown function. The C-terminal domain is predicted (by AlphaFold) to adopt a fold similar to the C-terminal domain of Prp3, an essential U4/U6 di-snRNP-associated protein which plays a role in pre-mRNA splicing. The Prp3 C-terminal domain is a single-stranded RNA-binding domain.


:

Pssm-ID: 467814  Cd Length: 122  Bit Score: 180.53  E-value: 3.79e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8393018  187 FTRLWIYSHHIYNKCKRKNILEWAKELSLSGFSMPGKPGVVCVEGPQSACEEFWSRLRKLNWKRILIRHREDIPFDGtnd 266
Cdd:cd24163   1 LGRRWIYSHHIYSKKKRKDIVEWAKELGLTGFSKPGKPGVICVEGDEEDVDEYVRRIRRLRWKKIQVRGEEVIEVPR--- 77

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 8393018  267 eterqRKFSIFEEKVFSVNGARGNHMD-FGQLYQFLNTKGCGDVFQMFFG 315
Cdd:cd24163  78 -----FFGEEEDEERALPGGFRELHEDlMGELAAFLEEAGLEELFLTLFG 122
RWD_RWDD2 cd23829
RWD domain of RWD domain-containing protein 2A (RWDD2A), 2B (RWDD2B) and related proteins; ...
 35-166 6.89e-54

RWD domain of RWD domain-containing protein 2A (RWDD2A), 2B (RWDD2B) and related proteins; This subfamily includes RWDD2A, previously known as RWD domain-containing 2 (RWDD2) and RWDD2B, previously known in humans as chromosome 21 open reading frame (C21orf6). C21orf6 appears to be involved in monosomy 21 phenotype. The RWD domain may mediate protein-protein interactions.


:

Pssm-ID: 467663  Cd Length: 129  Bit Score: 172.37  E-value: 6.89e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8393018   35 QAEAQLAELDLLASMFPGENELIVNDQLAVAELKDCIEKKTMEGRSSKVYFTINMNLDvsdEKMAMFSLACILPFKYPAV 114
Cdd:cd23829   1 CLELQLSEIEMLQSMFPNEGELKLDDPSAVADLKRFLEGDTDSPLPSRLEFTINLKIE---EPKVKVELSVTLPHEYPSV 77

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 8393018  115 LPEITVRSVLLSRSQQTQLNTDLTAFLQKHCHGDVCILNATEWVREHASGYV 166
Cdd:cd23829  78 PPEIFVRSDSLSRSQQRQLNEDLSEYISSLERGELCILQIVQWLQDNASSYI 129
 
Name Accession Description Interval E-value
RWDD2_C cd24163
C-terminal domain of RWD domain-containing protein 2; RWDD2A, as well as RWDD2B, are small ...
 187-315 3.79e-57

C-terminal domain of RWD domain-containing protein 2; RWDD2A, as well as RWDD2B, are small proteins that contain an N-terminal RWD domain and a C-terminal domain of unknown function. The C-terminal domain is predicted (by AlphaFold) to adopt a fold similar to the C-terminal domain of Prp3, an essential U4/U6 di-snRNP-associated protein which plays a role in pre-mRNA splicing. The Prp3 C-terminal domain is a single-stranded RNA-binding domain.


Pssm-ID: 467814  Cd Length: 122  Bit Score: 180.53  E-value: 3.79e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8393018  187 FTRLWIYSHHIYNKCKRKNILEWAKELSLSGFSMPGKPGVVCVEGPQSACEEFWSRLRKLNWKRILIRHREDIPFDGtnd 266
Cdd:cd24163   1 LGRRWIYSHHIYSKKKRKDIVEWAKELGLTGFSKPGKPGVICVEGDEEDVDEYVRRIRRLRWKKIQVRGEEVIEVPR--- 77

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 8393018  267 eterqRKFSIFEEKVFSVNGARGNHMD-FGQLYQFLNTKGCGDVFQMFFG 315
Cdd:cd24163  78 -----FFGEEEDEERALPGGFRELHEDlMGELAAFLEEAGLEELFLTLFG 122
RWD_RWDD2 cd23829
RWD domain of RWD domain-containing protein 2A (RWDD2A), 2B (RWDD2B) and related proteins; ...
 35-166 6.89e-54

RWD domain of RWD domain-containing protein 2A (RWDD2A), 2B (RWDD2B) and related proteins; This subfamily includes RWDD2A, previously known as RWD domain-containing 2 (RWDD2) and RWDD2B, previously known in humans as chromosome 21 open reading frame (C21orf6). C21orf6 appears to be involved in monosomy 21 phenotype. The RWD domain may mediate protein-protein interactions.


Pssm-ID: 467663  Cd Length: 129  Bit Score: 172.37  E-value: 6.89e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8393018   35 QAEAQLAELDLLASMFPGENELIVNDQLAVAELKDCIEKKTMEGRSSKVYFTINMNLDvsdEKMAMFSLACILPFKYPAV 114
Cdd:cd23829   1 CLELQLSEIEMLQSMFPNEGELKLDDPSAVADLKRFLEGDTDSPLPSRLEFTINLKIE---EPKVKVELSVTLPHEYPSV 77

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 8393018  115 LPEITVRSVLLSRSQQTQLNTDLTAFLQKHCHGDVCILNATEWVREHASGYV 166
Cdd:cd23829  78 PPEIFVRSDSLSRSQQRQLNEDLSEYISSLERGELCILQIVQWLQDNASSYI 129
DUF1115 pfam06544
Protein of unknown function (DUF1115); This family represents the C-terminus of hypothetical ...
 190-312 1.89e-21

Protein of unknown function (DUF1115); This family represents the C-terminus of hypothetical eukaryotic proteins of unknown function.


Pssm-ID: 461943  Cd Length: 135  Bit Score: 88.12  E-value: 1.89e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8393018    190 LWIYSHHIYNKCKRKNILEWAKELSLSGFSMPGKP-GVVCVEGPQSACEEFWSR-LRKLNWKRILIRHREDIP------F 261
Cdd:pfam06544   1 AVFRIKSLSNPKHRFKIDKNAKQLGLTGFCILGPPfGLVVVEGGEKSIKKYKKLmLRRIKWTENPHEDFEAMKeitfewD 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 8393018    262 DGTNDETERQRKFSIFE----EKVFSVNGARgNHMDFGQLYQFLNTKGCGDVFQM 312
Cdd:pfam06544  81 NDEDNEGEDNKCELVWEgevkERAFRKWKFK-VCETEGEAREFLKKHGVEHYWDL 134
RWD pfam05773
RWD domain; This domain was identified in WD40 repeat proteins and Ring finger domain proteins. ...
 37-162 3.15e-14

RWD domain; This domain was identified in WD40 repeat proteins and Ring finger domain proteins. The function of this domain is unknown. GCN2 is the alpha-subunit of the only translation initiation factor (eIF2 alpha) kinase that appears in all eukaryotes. Its function requires an interaction with GCN1 via the domain at its N-terminus, which is termed the RWD domain after three major RWD-containing proteins: RING finger-containing proteins, WD-repeat-containing proteins, and yeast DEAD (DEXD)-like helicases. The structure forms an alpha + beta sandwich fold consisting of two layers: a four-stranded antiparallel beta-sheet, and three side-by-side alpha-helices.


Pssm-ID: 399058  Cd Length: 111  Bit Score: 67.73  E-value: 3.15e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8393018     37 EAQLAELDLLASMFPGENELIVNDQLavaelkdciekktmegRSSKVYFTINMNLDVSD-EKMAMFSLACILPFKYPAVL 115
Cdd:pfam05773   1 EEQEEELEALESIYPDEFEVISDSPY----------------ESLEIEIKLSLDSDESDsSHLPPLVLKFTLPEDYPDEP 64

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 8393018    116 PEITVRSVL-LSRSQQTQLNTDLTAFLQKHChGDVCILNATEWVREHA 162
Cdd:pfam05773  65 PKISLSSPWnLSDEQVLSLLEELEELAEENL-GEVMIFELIEWLQENL 111
RWD smart00591
domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily ...
 42-165 1.93e-13

domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain;


Pssm-ID: 214735  Cd Length: 107  Bit Score: 65.46  E-value: 1.93e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8393018      42 ELDLLASMFPGENELIVNDqlavaelkdciekktmeGRSSKVYFTINMNLDVSDEKMAMFSLACILPFKYPAVLPEITVR 121
Cdd:smart00591   1 ELEALESIYPEDFEVIDED-----------------ARIPEITIKLSPSSDEGEDQYVSLTLQVKLPENYPDEAPPISLL 63

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 8393018     122 SV-LLSRSQQTQLNTDLTAFLQKHChGDVCILNATEWVREHASGY 165
Cdd:smart00591  64 NSeGLSDEQLAELLKKLEEIAEENL-GEVMIFELVEKLQEFLSEF 107
PRK14422 PRK14422
acylphosphatase; Provisional
 210-244 2.48e-03

acylphosphatase; Provisional


Pssm-ID: 237712  Cd Length: 93  Bit Score: 36.64  E-value: 2.48e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 8393018   210 AKELSLSGFSMPGKPGVVCV--EGPQSACEEFWSRLR 244
Cdd:PRK14422  29 ALELGLTGYAANLADGRVQVvaEGPRAACEKLLQLLR 65
 
Name Accession Description Interval E-value
RWDD2_C cd24163
C-terminal domain of RWD domain-containing protein 2; RWDD2A, as well as RWDD2B, are small ...
 187-315 3.79e-57

C-terminal domain of RWD domain-containing protein 2; RWDD2A, as well as RWDD2B, are small proteins that contain an N-terminal RWD domain and a C-terminal domain of unknown function. The C-terminal domain is predicted (by AlphaFold) to adopt a fold similar to the C-terminal domain of Prp3, an essential U4/U6 di-snRNP-associated protein which plays a role in pre-mRNA splicing. The Prp3 C-terminal domain is a single-stranded RNA-binding domain.


Pssm-ID: 467814  Cd Length: 122  Bit Score: 180.53  E-value: 3.79e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8393018  187 FTRLWIYSHHIYNKCKRKNILEWAKELSLSGFSMPGKPGVVCVEGPQSACEEFWSRLRKLNWKRILIRHREDIPFDGtnd 266
Cdd:cd24163   1 LGRRWIYSHHIYSKKKRKDIVEWAKELGLTGFSKPGKPGVICVEGDEEDVDEYVRRIRRLRWKKIQVRGEEVIEVPR--- 77

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 8393018  267 eterqRKFSIFEEKVFSVNGARGNHMD-FGQLYQFLNTKGCGDVFQMFFG 315
Cdd:cd24163  78 -----FFGEEEDEERALPGGFRELHEDlMGELAAFLEEAGLEELFLTLFG 122
RWD_RWDD2 cd23829
RWD domain of RWD domain-containing protein 2A (RWDD2A), 2B (RWDD2B) and related proteins; ...
 35-166 6.89e-54

RWD domain of RWD domain-containing protein 2A (RWDD2A), 2B (RWDD2B) and related proteins; This subfamily includes RWDD2A, previously known as RWD domain-containing 2 (RWDD2) and RWDD2B, previously known in humans as chromosome 21 open reading frame (C21orf6). C21orf6 appears to be involved in monosomy 21 phenotype. The RWD domain may mediate protein-protein interactions.


Pssm-ID: 467663  Cd Length: 129  Bit Score: 172.37  E-value: 6.89e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8393018   35 QAEAQLAELDLLASMFPGENELIVNDQLAVAELKDCIEKKTMEGRSSKVYFTINMNLDvsdEKMAMFSLACILPFKYPAV 114
Cdd:cd23829   1 CLELQLSEIEMLQSMFPNEGELKLDDPSAVADLKRFLEGDTDSPLPSRLEFTINLKIE---EPKVKVELSVTLPHEYPSV 77

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 8393018  115 LPEITVRSVLLSRSQQTQLNTDLTAFLQKHCHGDVCILNATEWVREHASGYV 166
Cdd:cd23829  78 PPEIFVRSDSLSRSQQRQLNEDLSEYISSLERGELCILQIVQWLQDNASSYI 129
Prp3_C-like cd24140
C-terminal domain of Prp3 and related proteins; This group contains the C-terminal domains of ...
 187-315 1.49e-29

C-terminal domain of Prp3 and related proteins; This group contains the C-terminal domains of Prp3 and RWD domain-containing proteins 2/3. Predicted structures (by AlphaFold) of the C-terminal domains of RWDD2 and RWDD3 reveal similarity to the C-terminal domain of Prp3, an essential U4/U6 di-snRNP-associated protein which plays a role in pre-mRNA splicing. The Prp3 C-terminal domain is a single-stranded RNA-binding domain.


Pssm-ID: 467812  Cd Length: 117  Bit Score: 109.27  E-value: 1.49e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8393018  187 FTRLWIYSHHIYNKCKRKNILEWAKELSLSGFSMPGK-PGVVCVEGPQSACEEFWSRLRKLNWKRILIRHREDIPFDGTN 265
Cdd:cd24140   1 YHCKVFHFKHLQNKKKRFKIKENSKELSLKGLCMRIRdPGIIIVVGNEKSCKEYENLVKKRKWNEDFELHTNTGDIKEKC 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 8393018  266 deterqrkfsifEEKVFSVNGaRGNHMDFGQLYQFLNTKGCGDVFQMFFG 315
Cdd:cd24140  81 ------------HNNSISKTW-EGYLQDCKFKGWFLKVCNDQYSLLRTLG 117
DUF1115 pfam06544
Protein of unknown function (DUF1115); This family represents the C-terminus of hypothetical ...
 190-312 1.89e-21

Protein of unknown function (DUF1115); This family represents the C-terminus of hypothetical eukaryotic proteins of unknown function.


Pssm-ID: 461943  Cd Length: 135  Bit Score: 88.12  E-value: 1.89e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8393018    190 LWIYSHHIYNKCKRKNILEWAKELSLSGFSMPGKP-GVVCVEGPQSACEEFWSR-LRKLNWKRILIRHREDIP------F 261
Cdd:pfam06544   1 AVFRIKSLSNPKHRFKIDKNAKQLGLTGFCILGPPfGLVVVEGGEKSIKKYKKLmLRRIKWTENPHEDFEAMKeitfewD 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 8393018    262 DGTNDETERQRKFSIFE----EKVFSVNGARgNHMDFGQLYQFLNTKGCGDVFQM 312
Cdd:pfam06544  81 NDEDNEGEDNKCELVWEgevkERAFRKWKFK-VCETEGEAREFLKKHGVEHYWDL 134
RWD pfam05773
RWD domain; This domain was identified in WD40 repeat proteins and Ring finger domain proteins. ...
 37-162 3.15e-14

RWD domain; This domain was identified in WD40 repeat proteins and Ring finger domain proteins. The function of this domain is unknown. GCN2 is the alpha-subunit of the only translation initiation factor (eIF2 alpha) kinase that appears in all eukaryotes. Its function requires an interaction with GCN1 via the domain at its N-terminus, which is termed the RWD domain after three major RWD-containing proteins: RING finger-containing proteins, WD-repeat-containing proteins, and yeast DEAD (DEXD)-like helicases. The structure forms an alpha + beta sandwich fold consisting of two layers: a four-stranded antiparallel beta-sheet, and three side-by-side alpha-helices.


Pssm-ID: 399058  Cd Length: 111  Bit Score: 67.73  E-value: 3.15e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8393018     37 EAQLAELDLLASMFPGENELIVNDQLavaelkdciekktmegRSSKVYFTINMNLDVSD-EKMAMFSLACILPFKYPAVL 115
Cdd:pfam05773   1 EEQEEELEALESIYPDEFEVISDSPY----------------ESLEIEIKLSLDSDESDsSHLPPLVLKFTLPEDYPDEP 64

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 8393018    116 PEITVRSVL-LSRSQQTQLNTDLTAFLQKHChGDVCILNATEWVREHA 162
Cdd:pfam05773  65 PKISLSSPWnLSDEQVLSLLEELEELAEENL-GEVMIFELIEWLQENL 111
RWD smart00591
domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily ...
 42-165 1.93e-13

domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain;


Pssm-ID: 214735  Cd Length: 107  Bit Score: 65.46  E-value: 1.93e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8393018      42 ELDLLASMFPGENELIVNDqlavaelkdciekktmeGRSSKVYFTINMNLDVSDEKMAMFSLACILPFKYPAVLPEITVR 121
Cdd:smart00591   1 ELEALESIYPEDFEVIDED-----------------ARIPEITIKLSPSSDEGEDQYVSLTLQVKLPENYPDEAPPISLL 63

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 8393018     122 SV-LLSRSQQTQLNTDLTAFLQKHChGDVCILNATEWVREHASGY 165
Cdd:smart00591  64 NSeGLSDEQLAELLKKLEEIAEENL-GEVMIFELVEKLQEFLSEF 107
RWD_RWDD3 cd23819
RWD domain of RWD domain-containing protein 3 (RWDD3) and related proteins; RWDD3, also called ...
 42-161 2.50e-12

RWD domain of RWD domain-containing protein 3 (RWDD3) and related proteins; RWDD3, also called RWD domain-containing sumoylation enhancer (RSUME), acts as an enhancer of SUMO conjugation and has no effect on ubiquitination. It increases protein sumoylation (a dynamic ubiquitin-like post translational modification) of several proteins including HIF1alpha and I-kappa-B, through direct interaction with UBC9. Its RWD domain is required for the sumoylation enhancement activity.


Pssm-ID: 467655  Cd Length: 106  Bit Score: 62.34  E-value: 2.50e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8393018   42 ELDLLASMFPGENELIVNDQlavaelkdcieKKTmegrSSKVYFTINMNLDVSDEKMAmFSLACILPFKYPAVLPEITVR 121
Cdd:cd23819   2 ELSVLQAIFCGPGEFEVLSS-----------SET----SDGVSFKIQISVEGFDEDIV-LKLTFHLSPNYPSSLPDISVS 65

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 8393018  122 SVLLSRSQQTQLNTDLTAFLQKHcHGDVCILNATEWVREH 161
Cdd:cd23819  66 SEQLTRAQCNDLQDSLLEYANSL-LGEPMVLELVLWLQEN 104
RWD_DRWD_ELF-like cd11605
RWD, DRWD, and ELF domain family; The family includes the RWD, double-RWD (DRWD), and ELF ...
 45-158 6.01e-06

RWD, DRWD, and ELF domain family; The family includes the RWD, double-RWD (DRWD), and ELF domains. They belong to the ubiquitin-conjugating (UBC) superfamily that represents a structural domain with an alpha-beta(4)-alpha(3) core fold. The RWD domain (named after three major RWD-containing proteins: RING finger, WD-repeat-containing proteins and DEXD-like helicases) mediates protein-protein interactions in a variety of pathways in eukaryotes. The DRWD domain is responsible for substrate binding. It is involved in interactions with other kinetochore proteins. The ELF (N-terminal E2-like fold) domain is found in all Fanconi anemia group L protein (FANCL) homologs. It is required to promote efficient DNA damage-induced FANCD2 (Fanconi anemia group D2 protein) monoubiquitination in vertebrate cells.


Pssm-ID: 467641  Cd Length: 94  Bit Score: 44.10  E-value: 6.01e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8393018   45 LLASMFPGENELIVNDqlavaelkdciekktmegrsSKVYFTINMNLDVSDEKmAMFSLACILPFKY-PAVLPEITVRSV 123
Cdd:cd11605   1 ALESIYGDELEVLSDD--------------------SPLRFSIRLSPEEEEDD-PPLELEFTLPPGYpPEEPPLITLRSP 59

                        90       100       110
                ....*....|....*....|....*....|....*
gi 8393018  124 LLSRSQQTQLNTDLTAFLQKHCHGDVCILNATEWV 158
Cdd:cd11605  60 KLSSAERLSLLKLELEEAAEENLGEPMLFDLVEAL 94
RWD_GCN2 cd23823
RWD domain of eIF-2-alpha kinase GCN2 and related proteins; GCN2 (EC 2.7.11.1), also called ...
 36-160 2.50e-04

RWD domain of eIF-2-alpha kinase GCN2 and related proteins; GCN2 (EC 2.7.11.1), also called eukaryotic translation initiation factor 2-alpha kinase 4 (EIF2AK4), acts as a metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to low amino acid availability. It also plays a role in modulating the adaptive immune response to yellow fever virus infection and promotes dendritic cells to initiate autophagy and antigene presentation to both CD4(+) and CD8(+) T-cells under amino acid starvation.


Pssm-ID: 467659  Cd Length: 117  Bit Score: 39.89  E-value: 2.50e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8393018   36 AEAQLAELDLLASMFPGENELIVNDQLAVAELKDCIEKKTMEGRSSKVYFTINMNldvsdekmamfslaCILPFKYPAVL 115
Cdd:cd23823   1 EEEQEEELEALQSIYGDDFEDLSSKKAVWSPPEFRIRLRPQEGESEENHVSVDLH--------------VKFPPTYPDVP 66

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 8393018  116 PEITVRSVL-LSRSQQTQLNTDLTAFLQKHChGDVCILNATEWVRE 160
Cdd:cd23823  67 PEIELENVKgLSDEQLEELLKELEELAKELL-GEEMIFELAEAVQE 111
PRK14422 PRK14422
acylphosphatase; Provisional
 210-244 2.48e-03

acylphosphatase; Provisional


Pssm-ID: 237712  Cd Length: 93  Bit Score: 36.64  E-value: 2.48e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 8393018   210 AKELSLSGFSMPGKPGVVCV--EGPQSACEEFWSRLR 244
Cdd:PRK14422  29 ALELGLTGYAANLADGRVQVvaEGPRAACEKLLQLLR 65
RWD_RNF25 cd23818
RWD domain of RING finger protein 25 (RNF25) and related proteins; RNF25 (EC 2.3.2.27), also ...
 42-161 9.32e-03

RWD domain of RING finger protein 25 (RNF25) and related proteins; RNF25 (EC 2.3.2.27), also known as AO7, is a putative E3 ubiquitin-protein ligase that was initially identified as an interacting protein of the E2 ubiquitin-conjugating enzyme, Ubc5B. It is ubiquitously expressed in various tissues and is predominantly localized in the nucleus. RNF25 activates nuclear factor (NF)-kappaB-dependent gene expression upon stimulation with interleukin-1 beta (IL-1beta), or tumor necrosis factor (TNF), or overexpression of NF-kappaB-inducing kinase. It interacts with the p65 transactivation domain (TAD) and modulates its transcriptional activity.


Pssm-ID: 467654  Cd Length: 109  Bit Score: 35.21  E-value: 9.32e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8393018   42 ELDLLASMFPgeNELIVND-QLAVAELKDCIEKKTMEGRSSK-VYFTINMnldvsdekmamfslacILPFKYPAVLPEIT 119
Cdd:cd23818   4 ELEALEAIYP--DELKVVSeDGAPTELSITLHPATADDESEQyVRLTLVI----------------TLPPGYPEEPPKIS 65

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 8393018  120 VRSVL-LSRSQQTQLNTDLTAFLQKHChGDVCILNATEWVREH 161
Cdd:cd23818  66 LRNPRgLSDARLARLLSLLKELAEERA-GEPMLFELIELAKEF 107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH