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Conserved domains on  [gi|160358829|ref|NP_059067|]
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hemopexin precursor [Mus musculus]

Protein Classification

HX domain-containing protein( domain architecture ID 10056662)

HX domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 47-230 6.79e-49

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


:

Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 165.56  E-value: 6.79e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160358829  47 PEHClDTWSFDAATMDhNGTMLFFKGEFVWRGHSGTRE----LISARWKNPITSVDAAFRGP--DSVFLIKEDKVWVYPP 120
Cdd:cd00094    1 PDAC-DPLSFDAVTTL-RGELYFFKGRYFWRLSPGKPPgspfLISSFWPSLPSPVDAAFERPdtGKIYFFKGDKYWVYTG 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160358829 121 EKKENGYPKLFQEeFPGIPYPP--DAAVECHRGEcqseGVLFFQGNRKWFWDFATRTQK-------ERSWSTVGN-CTAA 190
Cdd:cd00094   79 KNLEPGYPKPISD-LGFPPTVKqiDAALRWPDNG----KTYFFKGDKYWRYDEKTQKMDpgypkliETDFPGVPDkVDAA 153

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 160358829 191 LRWL-ERYYCFQGNKFLRFNPVTGEVPPRYPLDARDYFVSC 230
Cdd:cd00094  154 FRWLdGYYYFFKGDQYWRFDPRSKEVRVGYPLKISSDWLGC 194
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 253-458 1.38e-40

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


:

Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 143.99  E-value: 1.38e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160358829 253 SRCSPDP--GLTALlsdhRGATYAFTGSHYWRLDSSRDGWHSWPIAHHWPQGPSTVDAAFSW--DDKVYLIQGTQVYVFL 328
Cdd:cd00094    2 DACDPLSfdAVTTL----RGELYFFKGRYFWRLSPGKPPGSPFLISSFWPSLPSPVDAAFERpdTGKIYFFKGDKYWVYT 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160358829 329 tkgGNNLVSGYPKRLEKeLGSPPgiSLETIDAAFSCPGSSRLYVSSGRRLWWLDLKSGAQA------TWTEVSWPHEKVD 402
Cdd:cd00094   78 ---GKNLEPGYPKPISD-LGFPP--TVKQIDAALRWPDNGKTYFFKGDKYWRYDEKTQKMDpgypklIETDFPGVPDKVD 151

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 160358829 403 GALCldkslgpntcsSNGSSLYFIHGPNLYCYSSIDKLNaakSLPQPQKVNS-ILGC 458
Cdd:cd00094  152 AAFR-----------WLDGYYYFFKGDQYWRFDPRSKEV---RVGYPLKISSdWLGC 194
 
Name Accession Description Interval E-value
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 47-230 6.79e-49

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 165.56  E-value: 6.79e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160358829  47 PEHClDTWSFDAATMDhNGTMLFFKGEFVWRGHSGTRE----LISARWKNPITSVDAAFRGP--DSVFLIKEDKVWVYPP 120
Cdd:cd00094    1 PDAC-DPLSFDAVTTL-RGELYFFKGRYFWRLSPGKPPgspfLISSFWPSLPSPVDAAFERPdtGKIYFFKGDKYWVYTG 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160358829 121 EKKENGYPKLFQEeFPGIPYPP--DAAVECHRGEcqseGVLFFQGNRKWFWDFATRTQK-------ERSWSTVGN-CTAA 190
Cdd:cd00094   79 KNLEPGYPKPISD-LGFPPTVKqiDAALRWPDNG----KTYFFKGDKYWRYDEKTQKMDpgypkliETDFPGVPDkVDAA 153

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 160358829 191 LRWL-ERYYCFQGNKFLRFNPVTGEVPPRYPLDARDYFVSC 230
Cdd:cd00094  154 FRWLdGYYYFFKGDQYWRFDPRSKEVRVGYPLKISSDWLGC 194
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 253-458 1.38e-40

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 143.99  E-value: 1.38e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160358829 253 SRCSPDP--GLTALlsdhRGATYAFTGSHYWRLDSSRDGWHSWPIAHHWPQGPSTVDAAFSW--DDKVYLIQGTQVYVFL 328
Cdd:cd00094    2 DACDPLSfdAVTTL----RGELYFFKGRYFWRLSPGKPPGSPFLISSFWPSLPSPVDAAFERpdTGKIYFFKGDKYWVYT 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160358829 329 tkgGNNLVSGYPKRLEKeLGSPPgiSLETIDAAFSCPGSSRLYVSSGRRLWWLDLKSGAQA------TWTEVSWPHEKVD 402
Cdd:cd00094   78 ---GKNLEPGYPKPISD-LGFPP--TVKQIDAALRWPDNGKTYFFKGDKYWRYDEKTQKMDpgypklIETDFPGVPDKVD 151

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 160358829 403 GALCldkslgpntcsSNGSSLYFIHGPNLYCYSSIDKLNaakSLPQPQKVNS-ILGC 458
Cdd:cd00094  152 AAFR-----------WLDGYYYFFKGDQYWRFDPRSKEV---RVGYPLKISSdWLGC 194
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 97-139 2.87e-06

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 44.16  E-value: 2.87e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 160358829    97 VDAAFRGPDS-VFLIKEDKVWVYPPEKKENGYPKLFQEEFPGIP 139
Cdd:smart00120   1 IDAAFELRDGkTYFFKGDKYWRFDPKRVDPGYPKLISSFFPGLP 44
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 97-139 5.21e-05

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 40.24  E-value: 5.21e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 160358829   97 VDAAFR-GPDSVFLIKEDKVWVYPPEKKENGYPKLFqEEFPGIP 139
Cdd:pfam00045   1 IDAAFEdRDGKTYFFKGRKYWRFDPQRVEPGYPKLI-SDFPGLP 43
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 261-304 1.21e-04

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 39.53  E-value: 1.21e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 160358829   261 LTALLSDHRGATYAFTGSHYWRLDSSR-DGWHSWPIAHHWPQGPS 304
Cdd:smart00120   1 IDAAFELRDGKTYFFKGDKYWRFDPKRvDPGYPKLISSFFPGLPC 45
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 263-304 5.76e-03

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 34.85  E-value: 5.76e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 160358829  263 ALLSDHRGATYAFTGSHYWRLDSSR-DGWHSWPIAhHWPQGPS 304
Cdd:pfam00045   3 AAFEDRDGKTYFFKGRKYWRFDPQRvEPGYPKLIS-DFPGLPC 44
 
Name Accession Description Interval E-value
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 47-230 6.79e-49

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 165.56  E-value: 6.79e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160358829  47 PEHClDTWSFDAATMDhNGTMLFFKGEFVWRGHSGTRE----LISARWKNPITSVDAAFRGP--DSVFLIKEDKVWVYPP 120
Cdd:cd00094    1 PDAC-DPLSFDAVTTL-RGELYFFKGRYFWRLSPGKPPgspfLISSFWPSLPSPVDAAFERPdtGKIYFFKGDKYWVYTG 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160358829 121 EKKENGYPKLFQEeFPGIPYPP--DAAVECHRGEcqseGVLFFQGNRKWFWDFATRTQK-------ERSWSTVGN-CTAA 190
Cdd:cd00094   79 KNLEPGYPKPISD-LGFPPTVKqiDAALRWPDNG----KTYFFKGDKYWRYDEKTQKMDpgypkliETDFPGVPDkVDAA 153

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 160358829 191 LRWL-ERYYCFQGNKFLRFNPVTGEVPPRYPLDARDYFVSC 230
Cdd:cd00094  154 FRWLdGYYYFFKGDQYWRFDPRSKEVRVGYPLKISSDWLGC 194
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 253-458 1.38e-40

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 143.99  E-value: 1.38e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160358829 253 SRCSPDP--GLTALlsdhRGATYAFTGSHYWRLDSSRDGWHSWPIAHHWPQGPSTVDAAFSW--DDKVYLIQGTQVYVFL 328
Cdd:cd00094    2 DACDPLSfdAVTTL----RGELYFFKGRYFWRLSPGKPPGSPFLISSFWPSLPSPVDAAFERpdTGKIYFFKGDKYWVYT 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160358829 329 tkgGNNLVSGYPKRLEKeLGSPPgiSLETIDAAFSCPGSSRLYVSSGRRLWWLDLKSGAQA------TWTEVSWPHEKVD 402
Cdd:cd00094   78 ---GKNLEPGYPKPISD-LGFPP--TVKQIDAALRWPDNGKTYFFKGDKYWRYDEKTQKMDpgypklIETDFPGVPDKVD 151

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 160358829 403 GALCldkslgpntcsSNGSSLYFIHGPNLYCYSSIDKLNaakSLPQPQKVNS-ILGC 458
Cdd:cd00094  152 AAFR-----------WLDGYYYFFKGDQYWRFDPRSKEV---RVGYPLKISSdWLGC 194
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 97-139 2.87e-06

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 44.16  E-value: 2.87e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 160358829    97 VDAAFRGPDS-VFLIKEDKVWVYPPEKKENGYPKLFQEEFPGIP 139
Cdd:smart00120   1 IDAAFELRDGkTYFFKGDKYWRFDPKRVDPGYPKLISSFFPGLP 44
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 97-139 5.21e-05

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 40.24  E-value: 5.21e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 160358829   97 VDAAFR-GPDSVFLIKEDKVWVYPPEKKENGYPKLFqEEFPGIP 139
Cdd:pfam00045   1 IDAAFEdRDGKTYFFKGRKYWRFDPQRVEPGYPKLI-SDFPGLP 43
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 261-304 1.21e-04

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 39.53  E-value: 1.21e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 160358829   261 LTALLSDHRGATYAFTGSHYWRLDSSR-DGWHSWPIAHHWPQGPS 304
Cdd:smart00120   1 IDAAFELRDGKTYFFKGDKYWRFDPKRvDPGYPKLISSFFPGLPC 45
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 56-92 1.68e-04

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 39.15  E-value: 1.68e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 160358829    56 FDAATMDHNGTMLFFKGEFVWR-----GHSGTRELISARWKN 92
Cdd:smart00120   1 IDAAFELRDGKTYFFKGDKYWRfdpkrVDPGYPKLISSFFPG 42
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 56-77 4.36e-04

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 37.93  E-value: 4.36e-04
                          10        20
                  ....*....|....*....|..
gi 160358829   56 FDAATMDHNGTMLFFKGEFVWR 77
Cdd:pfam00045   1 IDAAFEDRDGKTYFFKGRKYWR 22
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 263-304 5.76e-03

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 34.85  E-value: 5.76e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 160358829  263 ALLSDHRGATYAFTGSHYWRLDSSR-DGWHSWPIAhHWPQGPS 304
Cdd:pfam00045   3 AAFEDRDGKTYFFKGRKYWRFDPQRvEPGYPKLIS-DFPGLPC 44
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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